@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3089: (2016-05-16 )
MKNIGWMLRQRATVSPRLQAYVEPSTDVRMTYAQMNALANRCADVLTALGIAKGDRVALLMPNSVEFCCLFYGAAKLGAVAVPINTRLAAPEVSFILSDSGSKVVIYGAPSAPVIDAIRAQADPPGTVTDWIGADSLAERLRSAAADEPAVECGGDDNLFIMYTSGTTGHPKGVVHTHESVHSAASSWASTIDVRYRDRLLLPLPMFHVAALTTVIFSAMRGVTLISMPQFDATKVWSLIVEERVCIGGAVPAILNFMRQVPEFAELDAPDFRYFITGGAPMPEALIKIYAAKNIEVVQGYALTESCGGGTLLLSEDALRKAGSAGRATMFTDVAVRGDDGVIREHGEGEVVIKSDILLKEYWNRPEATRDAFDNGWFRTGDIGEIDDEGYLYIKDRLKDMIISGGENVYPAEIESVIIGVPGVSEVAVIGLPDEKWGEIAAAIVVADQNEVSEQQIVEYCGTRLARYKLPKKVIFAEAIPRNPTGKILKTVLREQYSATVPK
Atome Classification :
(22 SA)
.........10........20...--.----....30........40........50........60........70........80........90........100.......110.......120---------..-.--.....130----.-..---...-------.140.-.-----.-.-------...150---........160.......170.......180-......----..-190--..-------...-...200...-.....210----...-....220...-.....230..--.......240.......250......----.260..--.....270.......280......-.290.-.--.-..-...300.....---------..310...---....320.......330....----...-340-..-.....-.--.350..-.....360.......370.-.-.-....380.......390.......400.......410.......420.......430...-....440....-...450----...---.....460-........-470.......480.......490.......500.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MK
N
I
G
W
M
L
R
QRATV
S
P
R
L
Q
A
Y
VEP--S----TDV
R
M
T
Y
A
Q
M
N
A
L
A
N
R
C
A
D
V
L
T
A
LGIAKG
D
R
V
A
L
LMPNS
V
E
F
C
C
L
F
YGAAKL
G
A
V
A
V
PINTRLAA
P
E
V
S
F
I
LSDSG
S
K
V
V
I
YGAPSA
P
V
I
D
A
I
RAQ----------AD-P--PGT
V
T
D
WI----
G
-
A
D
---
S
L
A
-------
E
R
L
R
S
-A-----A-A-------DEPAV----ECGGDD
N
L
F
I
M
Y
TSGTTGHPKG
V
V
H
T
H
E
S
V
--
H
S
A
A
S
S
----
W
A
-
S
T
---
I
D
-------
V
R
Y-R
D
R
LL-L
P
L
-
P
M
F
H
V
A
A
L
----
T
T
V
-
I
F
S
A
MR-
G
V
T
-
L
I
SMPQ--F
D
--
A
T
K
V
W
S
L
I
V
E
ERVCIG
G
A
V
P
A
I
L
N
F
M
----
R
QV
P
E
F
--AELDAP
D
F
R
Y
F
ITGGAP
M
P
E
A
L
I
K
-
I
Y
A-A-K--N-
I
E
-
V
V
Q
G
Y
ALTESC---------GG
G
T
L
L
L
S
---
E
D
A
L
R
KAGSAGR
A
T
M
F
T
D
V
A
V
----RGD-D---
G
V
-
I
REHG-E--
G
E
V
V
I
K-
S
D
I
L
L
K
E
Y
WNRPEAT
R
D
AF-D-N-GWFRTGDIGEIDDE
G
Y
L
Y
I
K
D
R
L
K
D
M
I
ISGGENV
Y
P
A
E
I
E
S
V
I
IGVPGVS
E
V
A
V
IGLPD
E
-
K
W
G
E
I
A
A
A
I
V
V
-ADQN-E----V
S
E
---
Q
Q
I
V
E
Y
-
C
-
G
T
R
L
A
R
YK-LP
K
K
V
I
F
A
EAIPRNP
T
G
K
I
L
K
T
V
L
R
E
Q
Y
SATVPK
1
PsiBlast_PDB
99.37
100%
-125
- C1 -
3R44
2
FAC13_MYCTU
A:
[15-516]
M
K
N
I
G
W
M
L
R
Q
R
A
T
V
S
P
R
L
Q
A
Y
V
E
P
--
S
----
T
D
V
R
M
T
Y
A
Q
M
N
A
L
A
N
R
C
A
D
V
L
T
A
L
G
I
A
K
G
D
R
V
A
L
L
M
P
N
S
V
E
F
C
C
L
F
Y
G
A
A
K
L
G
A
V
A
V
P
I
N
T
R
L
A
A
P
E
V
S
F
I
L
S
D
S
G
S
K
V
V
I
Y
G
A
P
S
A
P
V
I
D
A
I
R
A
Q
----------
A
D
-
P
--
P
G
T
V
T
D
W
I
----
G
-
A
D
---
S
L
A
-------
E
R
L
R
S
-
A
-----
A
-
A
-------
D
E
P
A
V
----
E
C
G
G
D
D
N
L
F
I
M
Y
T
S
---
G
H
P
K
G
V
V
H
T
H
E
S
V
--
H
S
A
A
S
S
----
W
A
-
S
T
---
I
D
-------
V
R
Y
-
R
D
R
L
L
-
L
P
L
-
P
M
F
H
V
A
A
L
----
T
T
V
-
I
F
S
A
M
R
-
G
V
T
-
L
I
S
M
P
Q
--
F
D
--
A
T
K
V
W
S
L
I
V
E
E
R
V
C
I
G
G
A
V
P
A
I
L
N
F
M
----
R
Q
V
P
E
F
--
A
E
L
D
A
P
D
F
R
Y
F
I
T
G
G
A
P
M
P
E
A
L
I
K
-
I
Y
A
-
A
-
K
--
N
-
I
E
-
V
V
Q
G
Y
A
L
T
E
S
C
---------
G
G
G
T
L
L
L
S
---
E
D
A
L
R
K
A
G
S
A
G
R
A
T
M
F
T
D
V
A
V
----
R
G
D
-
D
---
G
V
-
I
R
E
H
G
-
E
--
G
E
V
V
I
K
-
S
D
I
L
L
K
E
Y
W
N
R
P
E
A
T
R
D
A
F
-
D
-
N
-
G
W
F
R
T
G
D
I
G
E
I
D
D
E
G
Y
L
Y
I
K
D
R
L
K
D
M
I
I
S
G
G
E
N
V
Y
P
A
E
I
E
S
V
I
I
G
V
P
G
V
S
E
V
A
V
I
G
L
P
D
E
-
K
W
G
E
I
A
A
A
I
V
V
-
A
D
Q
N
-
E
----
V
S
E
---
Q
Q
I
V
E
Y
-
C
-
G
T
R
L
A
R
Y
K
-
L
P
K
K
V
I
F
A
E
A
I
P
R
N
P
T
G
K
I
L
K
T
V
L
R
E
Q
Y
S
A
T
V
P
-
31
HHSearch
98.91
100%
-123
- C1 -
3R44
2
FAC13_MYCTU
A:
[16-516]
-
K
N
I
G
W
M
L
R
Q
R
A
T
V
S
P
R
L
Q
A
--
Y
V
EP
S
----
T
D
V
R
M
T
Y
A
Q
M
N
A
L
A
N
R
C
A
D
V
L
T
A
L
G
I
A
K
G
D
R
V
A
L
L
M
P
N
S
V
E
F
C
C
L
F
Y
G
A
A
K
L
G
A
V
A
V
P
I
N
T
R
L
A
A
P
E
V
S
F
I
L
S
D
S
G
S
K
V
V
I
Y
G
A
P
S
A
P
V
I
D
A
I
R
A
Q
----------
A
D
-
P
--
P
G
T
V
T
D
W
I
----
G
-
A
D
---
S
L
A
-------
E
R
L
R
S
-
A
-----
A
-
A
-------
D
E
P
A
V
----
E
C
G
G
D
D
N
L
F
I
M
Y
T
S
---
G
H
P
K
G
V
V
H
T
H
E
S
V
--
H
S
A
A
S
S
----
W
A
-
S
T
---
I
D
-------
V
R
Y
-
R
D
R
L
L
-
L
P
L
-
P
M
F
H
V
A
A
L
----
T
T
V
-
I
F
S
A
M
R
-
G
V
T
-
L
I
S
M
P
Q
--
F
D
--
A
T
K
V
W
S
L
I
V
E
E
R
V
C
I
G
G
A
V
P
A
I
L
N
F
M
----
R
Q
V
P
E
F
--
A
E
L
D
A
P
D
F
R
Y
F
I
T
G
G
A
P
M
P
E
A
L
I
K
-
I
Y
A
-
A
-
K
--
N
-
I
E
-
V
V
Q
G
Y
A
L
T
E
S
C
---------
G
G
G
T
L
L
L
S
---
E
D
A
L
R
K
A
G
S
A
G
R
A
T
M
F
T
D
V
A
V
----
R
G
D
-
D
---
G
V
-
I
R
E
H
G
-
E
--
G
E
V
V
I
K
-
S
D
I
L
L
K
E
Y
W
N
R
P
E
A
T
R
D
A
F
-
D
-
N
-
G
W
F
R
T
G
D
I
G
E
I
D
D
E
G
Y
L
Y
I
K
D
R
L
K
D
M
I
I
S
G
G
E
N
V
Y
P
A
E
I
E
S
V
I
I
G
V
P
G
V
S
E
V
A
V
I
G
L
P
D
E
-
K
W
G
E
I
A
A
A
I
V
V
-
A
D
Q
N
-
E
----
V
S
E
---
Q
Q
I
V
E
Y
-
C
-
G
T
R
L
A
R
Y
K
-
L
P
K
K
V
I
F
A
E
A
I
P
R
N
P
T
G
K
I
L
K
T
V
L
R
E
Q
Y
S
A
T
V
P
-
2
PsiBlast_PDB
86.74
100%
-125
- C1 -
3T5B
-
FAC13_MYCTU
A:
[1-396]
M
K
N
I
G
W
M
L
R
Q
R
A
T
V
S
P
R
L
Q
A
Y
V
E
P
--
S
----
T
D
V
R
M
T
Y
A
Q
M
N
A
L
A
N
R
C
A
D
V
L
T
A
L
G
I
A
K
G
D
R
V
A
L
L
M
P
N
S
V
E
F
C
C
L
F
Y
G
A
A
K
L
G
A
V
A
V
P
I
N
T
R
L
A
A
P
E
V
S
F
I
L
S
D
S
G
S
K
V
V
I
Y
G
A
P
S
A
P
V
I
D
A
I
R
A
Q
----------
A
D
-
P
--
P
G
T
V
T
D
W
I
----
G
-
A
D
---
S
L
A
-------
E
R
L
R
S
-
A
-----
A
-
A
-------
D
E
P
A
V
----
E
C
G
G
D
D
N
L
F
I
M
Y
T
S
G
T
T
G
H
P
K
G
V
V
H
T
H
E
S
V
--
H
S
A
A
S
S
----
W
A
-
S
T
---
I
D
-------
V
R
Y
-
R
D
R
L
L
-
L
P
L
-
P
M
F
H
V
A
A
L
----
T
T
V
-
I
F
S
A
M
R
-
G
V
T
-
L
I
S
M
P
Q
--
F
D
--
A
T
K
V
W
S
L
I
V
E
E
R
V
C
I
G
G
A
V
P
A
I
L
N
F
M
----
R
Q
V
P
E
F
--
A
E
L
D
A
P
D
F
R
Y
F
I
T
G
G
A
P
M
P
E
A
L
I
K
-
I
Y
A
-
A
-
K
--
N
-
I
E
-
V
V
Q
G
Y
A
L
T
E
S
C
---------
G
G
G
T
L
L
L
S
---
E
D
A
L
R
K
A
G
S
A
G
R
A
T
M
F
T
D
V
A
V
----
R
G
D
-
D
---
G
V
-
I
R
E
H
G
-
E
--
G
E
V
V
I
K
-
S
D
I
L
L
K
E
Y
W
N
R
P
E
A
T
R
D
A
F
-
D
-
N
-
G
W
F
R
T
G
D
I
G
E
I
D
D
E
G
Y
L
Y
I
K
D
------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
86.27
100%
-128
- C1 -
3T5C
-
FAC13_MYCTU
A:
[1-396]
M
K
N
I
G
W
M
L
R
Q
R
A
T
V
S
P
R
L
Q
A
Y
V
E
P
--
S
----
T
D
V
R
M
T
Y
A
Q
M
N
A
L
A
N
R
C
A
D
V
L
T
A
L
G
I
A
K
G
D
R
V
A
L
L
M
P
N
S
V
E
F
C
C
L
F
Y
G
A
A
K
L
G
A
V
A
V
P
I
N
T
R
L
A
A
P
E
V
S
F
I
L
S
D
S
G
S
K
V
V
I
Y
G
A
P
S
A
P
V
I
D
A
I
R
A
Q
----------
A
D
-
P
--
P
G
T
V
T
D
W
I
----
G
-
A
D
---
S
L
A
-------
E
R
L
R
S
-
A
-----
A
-
A
-------
D
E
P
A
V
----
E
C
G
G
D
D
N
L
F
I
M
Y
T
S
----
H
P
K
G
V
V
H
T
H
E
S
V
--
H
S
A
A
S
S
----
W
A
-
S
T
---
I
D
-------
V
R
Y
-
R
D
R
L
L
-
L
P
L
-
P
M
F
H
V
A
A
L
----
T
T
V
-
I
F
S
A
M
R
-
G
V
T
-
L
I
S
M
P
Q
--
F
D
--
A
T
K
V
W
S
L
I
V
E
E
R
V
C
I
G
G
A
V
P
A
I
L
N
F
M
----
R
Q
V
P
E
F
--
A
E
L
D
A
P
D
F
R
Y
F
I
T
G
G
A
P
M
P
E
A
L
I
K
-
I
Y
A
-
A
-
K
--
N
-
I
E
-
V
V
Q
G
Y
A
L
T
E
S
C
---------
G
G
G
T
L
L
L
S
---
E
D
A
L
R
K
A
G
S
A
G
R
A
T
M
F
T
D
V
A
V
----
R
G
D
-
D
---
G
V
-
I
R
E
H
G
-
E
--
G
E
V
V
I
K
-
S
D
I
L
L
K
E
Y
W
N
R
P
E
A
T
R
D
A
F
-
D
-
N
-
G
W
F
R
T
G
D
I
G
E
I
D
D
E
G
Y
L
Y
I
K
D
------------------------------------------------------------------------------------------------------------------------
34
HHSearch
73.96
28%
-94
- C1 -
4WV3
1
?
A:
[11-520]
--
N
A
V
D
I
L
E
R
N
L
P
V
R
A
N
K
T
A
--
L
F
--
T
----
P
D
R
E
M
T
F
R
Q
V
S
N
E
A
N
Q
V
G
N
A
L
K
G
L
G
V
R
F
G
E
C
V
G
L
L
T
L
D
S
A
E
W
V
T
S
F
F
G
I
V
K
L
G
A
I
A
V
G
I
N
T
L
L
K
P
P
E
Y
E
Y
I
L
R
D
C
R
A
R
V
L
I
V
H
Q
E
F
L
P
L
I
E
S
I
R
G
N
----------
L
P
-
M
LE
H
I
V
V
I
G
-------G
Y
L
---
S
F
N
-------
D
W
I
R
P
-
Q
-----
P
-
T
-------
T
L
E
A
A
----
Q
S
H
R
E
D
I
C
S
L
N
Y
S
S
G
-
T
G
G
P
K
G
I
P
H
A
H
K
D
Y
--
P
L
T
A
Q
L
W---
G
V
-
N
V
---
L
G
-------
L
R
E
-
S
D
R
T
F
-
A
L
A
-
K
L
F
F
T
F
G
T
----
G
G
N
L
I
F
P
W
Y
V
-
G
A
S
-
C
V
L
F
P
G
AA
R
V
--
A
S
N
V
L
S
T
I
S
R
F
K
P
T
I
F
Y
N
A
P
T
G
Y
A
A
A
----
L
A
L
K
D
F
--
S
Q
H
D
L
S
S
L
R
L
C
V
S
A
S
E
A
L
P
A
A
L
W
Y
-
A
W
K
-
E
A
T
--
G
-
V
D
-
I
I
D
G
I
G
C
T
E
N
F
---------
H
I
F
I
S
N
R
P
---
G
--
D
I
R
P
G
S
S
G
K
P
V
E
G
Y
E
L
K
L
----
V
D
D
-
E
---
G
K
-
T
V
P
A
G
E
I
--
G
N
V
L
L
R
-
S
E
T
A
A
L
S
Y
W
H
N
F
E
K
S
R
Q
T
F
-
Q
-
G
-
E
W
L
A
T
G
D
K
Y
F
V
D
A
D
G
Y
Y
W
H
A
G
R
S
D
D
M
L
K
V
G
G
I
W
V
S
P
V
E
V
E
S
T
L
I
Q
H
P
A
V
Q
E
C
A
V
I
G
C
P
D
Q
-
S
R
L
I
K
P
K
A
F
I
I
-
L
K
P
E
-
Q
I
P
S
E
A
L
I
---
R
Q
I
T
D
H
-
C
-
T
E
K
M
A
A
Y
K
-
R
P
R
W
I
E
F
V
T
E
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
R
S
A
A
K
L
A
A
--
5
PsiBlast_PDB
73.74
33%
-109
- C1 -
5BUS
3
MENE_BACSU
A:
[9-481]
----
N
W
L
M
-
Q
R
A
Q
L
T
P
E
R
I
A
L
I
----
Y
----
E
D
Q
T
V
T
F
A
E
L
F
A
A
S
K
R
M
A
E
Q
L
A
A
H
S
V
R
K
G
D
T
A
A
I
L
L
Q
N
R
A
E
M
V
Y
A
V
H
A
C
F
L
L
G
V
K
A
V
L
L
N
T
K
L
S
T
H
E
R
L
F
Q
L
E
D
S
G
S
G
F
L
L
T
D
S
S
---------
F
E
----------
K
K
-
E
--
Y
E
H
I
V
Q
T
I
----
D
-
V
D
---
E
L
M
-------
K
E
A
A
E
-
E
-----
I
-
E
-------
I
E
A
Y
M
----
Q
M
--
D
A
T
A
T
L
M
Y
T
S
G
T
T
G
K
P
K
G
V
Q
Q
T
F
G
N
H
--
Y
F
S
A
V
S
----
S
A
-
L
N
---
L
G
-------
I
T
E
-
Q
D
R
W
L
-
I
A
L
-
P
L
F
H
I
S
G
L
----
S
A
L
-
F
K
S
V
I
Y
-
G
M
T
-
V
V
L
H
Q
R
--
F
S
--
V
S
D
V
L
H
S
I
N
R
H
E
V
T
M
I
S
A
V
Q
T
M
L
A
S
L
L
E
E
T
N
R
C
P
E
---------
S
I
R
C
I
L
L
G
G
G
P
A
P
L
P
L
L
E
-
E
C
R
-
E
-
K
--
G
-
F
P
-
V
F
Q
S
Y
G
M
T
E
T
C
---------
S
Q
I
V
T
L
S
P
---
E
F
S
M
E
K
L
G
S
A
G
K
P
L
F
S
C
E
I
K
I
----
E
R
D
-
G
---
Q
V
-
C
E
P
Y
E
-
H
--
G
E
I
M
V
K
-
G
P
N
V
M
K
S
Y
F
N
R
E
S
A
N
E
A
S
F
-
Q
-
N
-
G
W
L
K
T
G
D
L
G
Y
L
D
N
E
G
F
L
Y
V
L
D
R
R
S
D
L
I
I
S
G
G
E
N
I
Y
P
A
E
V
E
S
V
L
L
S
H
P
A
V
A
E
A
G
V
S
G
A
E
D
K
-
K
--
K
V
P
H
A
Y
L
V
-
L
H
K
--
P
----
V
S
A
---
G
E
L
T
D
Y
-
C
-
K
E
R
L
A
K
Y
K
-
I
P
A
K
F
F
V
L
D
R
L
P
R
N
A
S
N
K
L
L
R
N
Q
L
K
D
--------
32
HHSearch
73.25
26%
-94
- C1 -
2D1S
3
LUCI_LUCCR
A:
[23-545]
-
G
S
A
G
T
Q
L
R
K
Y
M
E
R
Y
A
K
L
G
A
--
I
A
--
F
TNAV
T
G
V
D
Y
S
Y
A
E
Y
L
E
K
S
C
C
L
G
K
A
L
Q
N
Y
G
L
V
V
D
G
R
I
A
L
C
S
E
N
C
E
E
F
F
I
P
V
I
A
G
L
F
I
G
V
G
V
A
P
T
N
E
I
Y
T
L
R
E
L
V
H
S
L
G
I
S
K
P
T
I
V
F
S
S
K
K
G
L
D
K
V
I
T
V
Q
K
T
----------
V
T
T
I
K
-
T
I
V
I
L
D
S
K
VDYR
G
-
Y
Q
---
C
L
D
-------
T
F
I
K
R
N
T
PPGFQ
A
S
S
-------
F
K
T
V
E
----
V
D
R
K
E
Q
V
A
L
I
M
N
S
S
G
S
T
G
L
P
K
G
V
Q
L
T
H
E
N
I
--
V
T
R
F
S
H
----
A
R
-
D
P
IYG
N
Q
-------
V
S
P
-
G
T
A
V
L
-
T
V
V
-
P
F
H
H
G
F
G
M
----
F
T
T
-
L
G
Y
L
I
C
-
G
F
R
-
V
V
M
L
T
K
--
F
D
--
E
E
T
F
L
K
T
L
Q
D
Y
K
C
T
S
V
I
L
V
P
T
L
F
A
I
L
----
N
K
S
E
L
L
--
N
K
Y
D
L
S
N
L
V
E
I
A
S
G
G
A
P
L
S
K
E
V
G
E
-
A
V
A
-
R
R
F
--
N
L
P
G
-
V
R
Q
G
Y
G
L
T
E
T
T
---------
S
A
I
I
I
T
P
E
---
G
--
D
D
K
P
G
A
S
G
K
V
V
P
L
F
K
A
K
V
----
I
D
L
D
T
---
K
K
-
S
L
G
P
N
R
R
--
G
E
V
C
V
K
-
G
P
M
L
M
K
G
Y
V
N
N
P
E
A
T
K
E
L
I
D
E
-
E
-
G
W
L
H
T
G
D
I
G
Y
Y
D
E
E
K
H
F
F
I
V
D
R
L
K
S
L
I
K
Y
K
G
Y
Q
V
P
P
A
E
L
E
S
V
L
L
Q
H
P
S
I
F
D
A
G
V
A
G
V
P
D
P
-
V
A
G
E
L
P
G
A
V
V
V
-
L
E
S
G
-
K
N
---
M
T
E
---
K
E
V
M
D
Y
-
V
-
A
S
Q
V
S
N
A
K
R
L
R
G
G
V
R
F
V
D
E
V
P
K
G
L
T
G
K
I
D
G
R
A
I
R
E
I
L
K
K
P
V
--
10
PsiBlast_PDB
73.22
32%
-104
- C1 -
3NI2
4
?
A:
[51-532]
------------------------------------
T
Y
A
D
V
E
L
T
A
R
R
V
A
S
G
L
N
K
I
G
I
Q
Q
G
D
V
I
M
L
F
L
P
S
S
P
E
F
V
L
A
F
L
G
A
S
H
R
G
A
I
I
T
A
A
N
P
F
S
T
P
A
E
L
A
K
H
A
K
A
S
R
A
K
L
L
I
T
Q
A
C
Y
Y
E
K
V
K
D
F
A
R
E
----------
S
D
-
V
--
K
V
M
C
V
D
S
A
PD--
G
-
C
L
---
H
F
S
-------
E
L
T
Q
A
-
D
-----
E
-
N
-------
E
A
P
Q
V
----
D
I
S
P
D
D
V
V
A
L
P
Y
S
S
G
T
T
G
L
P
K
G
V
M
L
T
H
K
G
L
-----
I
T
S
----
V
A
-
Q
Q
---
V
D
GDNPN
L
Y
F
H
S
-
E
D
V
I
L
-
C
V
L
-
P
M
F
H
I
Y
A
L
----
N
S
I
-
M
L
C
G
L
R
V
G
A
P
-
I
L
I
M
P
K
--
F
E
--
I
G
S
L
L
G
L
I
E
K
Y
K
V
S
I
A
P
V
V
P
P
V
M
M
S
I
----
A
K
S
P
D
L
--
D
K
H
D
L
S
S
L
R
M
I
K
S
G
G
A
P
L
G
K
E
L
E
D
-
T
V
R
-
A
-
K
F
P
Q
-
A
R
-
L
G
Q
G
Y
G
M
T
E
A
G
---------
P
V
L
A
M
C
L
A
FAK
E
P
F
D
I
K
P
G
A
C
G
T
V
V
R
N
A
E
M
K
I
----
V
D
P
-
E
TG-
A
S
-
L
P
R
N
Q
-
P
--
G
E
I
C
I
R
-
G
D
Q
I
M
K
G
Y
L
N
D
P
E
A
T
S
R
T
I
-
D
-
K
E
G
W
L
H
T
G
D
I
G
Y
I
D
D
D
D
E
L
F
I
V
D
R
L
K
E
L
I
K
Y
K
G
F
Q
V
A
P
A
E
L
E
A
L
L
I
A
H
P
E
I
S
D
A
A
V
V
G
L
K
D
E
-
D
A
G
E
V
P
V
A
F
V
V
K
S
E
K
S
-
Q
----
A
T
E
---
D
E
I
K
Q
Y
-
I
-
S
K
Q
V
I
F
Y
K
-
R
I
K
R
V
F
F
I
E
A
I
P
K
A
P
S
G
K
I
L
R
K
N
L
K
E
K
-------
9
PsiBlast_PDB
73.13
32%
-105
- C1 -
3A9V
1
?
A:
[51-532]
------------------------------------
T
Y
A
D
V
E
L
T
A
R
R
V
A
S
G
L
N
K
I
G
I
Q
Q
G
D
V
I
M
L
F
L
P
S
S
P
E
F
V
L
A
F
L
G
A
S
H
R
G
A
I
I
T
A
A
N
P
F
S
T
P
A
E
L
A
K
H
A
K
A
S
R
A
K
L
L
I
T
Q
A
C
Y
Y
E
K
V
K
D
F
A
R
E
----------
S
D
-
V
--
K
V
M
C
V
D
S
A
PD--
G
-
C
L
---
H
F
S
-------
E
L
T
Q
A
-
D
-----
E
-
N
-------
E
A
P
Q
V
----
D
I
S
P
D
D
V
V
A
L
P
Y
S
S
G
T
T
G
L
P
K
G
V
M
L
T
H
K
G
L
-----
I
T
S
----
V
A
-
Q
Q
---
V
D
GDNPN
L
Y
F
H
S
-
E
D
V
I
L
-
C
V
L
-
P
M
F
H
I
Y
A
L
----
N
S
I
-
M
L
C
G
L
R
V
G
A
P
-
I
L
I
M
P
K
--
F
E
--
I
G
S
L
L
G
L
I
E
K
Y
K
V
S
I
A
P
V
V
P
P
V
M
M
S
I
----
A
K
S
P
D
L
--
D
K
H
D
L
S
S
L
R
M
I
K
S
G
G
A
P
L
G
K
E
L
E
D
-
T
V
R
-
A
-
K
F
P
Q
-
A
R
-
L
G
Q
G
Y
G
M
T
E
A
G
---------
P
V
L
A
M
C
L
A
FAK
E
P
F
D
I
K
P
G
A
C
G
T
V
V
R
N
A
E
M
K
I
----
V
D
P
-
E
TG-
A
S
-
L
P
R
N
Q
-
P
--
G
E
I
C
I
R
-
G
D
Q
I
M
K
G
Y
L
N
D
P
E
A
T
S
R
T
I
-
D
-
K
E
G
W
L
H
T
G
D
I
G
Y
I
D
D
D
D
E
L
F
I
V
D
R
L
K
E
L
I
K
Y
K
G
F
Q
V
A
P
A
E
L
E
A
L
L
I
A
H
P
E
I
S
D
A
A
V
V
G
L
K
D
E
-
D
A
G
E
V
P
V
A
F
V
V
K
S
E
K
S
-
Q
----
A
T
E
---
D
E
I
K
Q
Y
-
I
-
S
K
Q
V
I
F
Y
K
-
R
I
K
R
V
F
F
I
E
A
I
P
K
A
P
S
G
K
I
L
R
K
N
L
K
E
K
-------
6
PsiBlast_PDB
73.08
34%
-112
- C1 -
4FUQ
7
?
A:
[21-499]
---------------------
I
E
T
--
A
----
A
G
D
K
I
S
Y
A
E
L
V
A
R
A
G
R
V
A
N
V
L
V
A
R
G
L
Q
V
G
D
R
V
A
A
Q
T
E
K
S
V
E
A
L
V
L
Y
L
A
T
V
R
A
G
G
V
Y
L
P
L
N
T
A
Y
T
L
H
E
L
D
Y
F
I
T
D
A
E
P
K
I
V
V
C
D
P
S
K
R
D
G
I
A
A
I
A
A
K
----------
V
------
G
A
T
V
E
T
L
----
G
-
P
D
GRG
S
L
T
-------
D
A
A
A
G
-
A
-----
S
-
E
-------
A
F
A
T
I
----
D
R
G
A
D
D
L
A
A
I
L
Y
T
S
--
T
G
R
S
K
G
A
M
L
S
H
D
N
L
--
A
S
N
S
L
T
L
V
D
Y
W
R
-
F
T
---
P
D
------------
D
V
L
I
-
H
A
L
-
P
I
Y
H
T
H
G
L
F
V
A
S
N
V
T
-
L
F
A
--
R
-
G
-
S
-
M
I
F
L
P
K
--
F
D
--
P
D
K
I
L
D
L
M
A
R
A
T
V
L
M
G
--
V
P
T
F
Y
T
R
L
----
L
Q
S
P
R
L
--
T
K
E
T
T
G
H
M
R
L
F
I
S
G
S
A
P
L
L
A
D
T
H
R
-
E
W
S
-
A
-
K
--
T
-
G
H
A
V
L
E
R
Y
G
M
T
E
T
N
---------
M
N
T
S
N
P
Y
D
---
G
D
--
R
V
P
G
A
V
G
P
A
--
L
P
G
V
S
A
----
R
V
T
-
D
PET
G
K
-
E
L
P
R
G
-
D
I-
G
M
I
E
V
K
-
G
P
N
V
F
K
G
Y
W
R
M
P
E
K
T
K
S
E
F
R
D
-
D
-
G
F
F
I
T
G
D
L
G
K
I
D
E
R
G
Y
V
H
I
L
G
R
G
K
D
L
V
I
T
G
G
F
N
V
Y
P
K
E
I
E
S
E
I
D
A
M
P
G
V
V
E
S
A
V
I
G
V
P
H
A
-
D
F
G
E
G
V
T
A
V
V
V
-
R
D
K
G
A
T
----
I
D
E
---
A
Q
V
L
H
G
-
L
-
D
G
Q
L
A
K
F
K
-
M
P
K
K
V
I
F
V
D
D
L
P
R
N
T
M
G
K
V
Q
K
N
V
L
R
E
T
Y
K
-----
17
PsiBlast_PDB
72.52
29%
-105
- C1 -
4WV3
1
?
A:
[33-513]
--------------------------------
D
R
E
M
T
F
R
Q
V
S
N
E
A
N
Q
V
G
N
A
L
K
G
L
G
V
R
F
G
E
C
V
G
L
L
T
L
D
S
A
E
W
V
T
S
F
F
G
I
V
K
L
G
A
I
A
V
G
I
N
T
L
L
K
P
P
E
Y
E
Y
I
L
R
D
C
R
A
R
V
L
I
V
H
Q
E
F
L
P
L
I
E
S
I
R
G
N
LPMLE
H
I
V
V
I
G
-----------------
G
-
Y
L
---
S
F
N
-------
D
W
I
R
P
-
Q
-----
P
-
T
-------
T
L
E
A
A
----
Q
S
H
R
E
D
I
C
S
L
N
Y
S
S
G
-
T
G
G
P
K
G
I
P
H
A
H
K
D
Y
--
P
L
T
A
Q
L
----
W
G
V
N
V
---
L
G
-------
L
R
E
-
S
D
R
T
F
A
L
A
K
-
L
F
F
T
F
G
T
G
----
G
N
L
-
I
F
P
W
Y
V
-
G
A
S
-
C
V
L
F
P
G
--
A
A
RV
A
S
N
V
L
S
T
I
S
R
F
K
P
T
I
F
Y
N
A
P
T
G
Y
A
A
A
----
L
A
L
K
D
F
--
S
Q
H
D
L
S
S
L
R
L
C
V
S
A
S
E
A
L
P
A
A
L
W
Y
-
A
W
K
E
A
-
T
--
G
-
V
D
-
I
I
D
G
I
G
C
T
E
N
F
---------
H
--
I
F
I
S
N
---
R
P
G
D
I
R
P
G
S
S
G
K
P
V
E
G
Y
E
L
K
L
----
V
D
D
-
E
---
G
K
-
T
V
P
A
G
-
E
I
-
G
N
V
L
L
R
-
S
E
T
A
A
L
S
Y
W
H
N
F
E
K
S
R
Q
T
F
-
Q
-
G
-
E
W
L
A
T
G
D
K
Y
F
V
D
A
D
G
Y
Y
W
H
A
G
R
S
D
D
M
L
K
V
G
G
I
W
V
S
P
V
E
V
E
S
T
L
I
Q
H
P
A
V
Q
E
C
A
V
I
G
C
P
D
Q
S
R
L
I
K
P
K
A
F
I
I
L
-
K
P
E
Q
-
I
----
P
S
E
A
L
I
R
Q
I
T
D
H
-
C
-
T
E
K
M
A
A
Y
K
-
R
P
R
W
I
E
F
V
T
E
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
R
---------
4
PsiBlast_PDB
72.50
33%
-109
- C1 -
5BUR
9
MENE_BACSU
A:
[9-481]
----
N
W
L
M
-
Q
R
A
Q
L
T
P
E
R
I
A
L
I
----
Y
----
E
D
Q
T
V
T
F
A
E
L
F
A
A
S
K
R
M
A
E
Q
L
A
A
H
S
V
R
K
G
D
T
A
A
I
L
L
Q
N
R
A
E
M
V
Y
A
V
H
A
C
F
L
L
G
V
K
A
V
L
L
N
T
K
L
S
T
H
E
R
L
F
Q
L
E
D
S
G
S
G
F
L
L
T
D
S
S
---------
F
E
----------
K
K
-
E
--
Y
E
H
I
V
Q
T
I
----
D
-
V
D
---
E
L
M
-------
K
E
A
A
E
-
E
-----
I
-
E
-------
I
E
A
Y
M
----
Q
M
--
D
A
T
A
T
L
M
Y
T
S
G
T
T
G
K
P
K
G
V
Q
Q
T
F
G
N
H
--
Y
F
S
A
V
S
----
S
A
-
L
N
---
L
G
-------
I
T
E
-
Q
D
R
W
L
-
I
A
L
-
P
L
F
H
I
S
G
L
----
S
A
L
-
F
K
S
V
I
Y
-
G
M
T
-
V
V
L
H
Q
R
--
F
S
--
V
S
D
V
L
H
S
I
N
R
H
E
V
T
M
I
S
A
V
Q
T
M
L
A
S
L
L
E
E
T
N
R
C
P
E
---------
S
I
R
C
I
L
L
G
G
G
P
A
P
L
P
L
L
E
-
E
C
R
-
E
-
K
--
G
-
F
P
-
V
F
Q
S
Y
G
M
T
E
T
C
---------
S
Q
I
V
T
L
S
P
---
E
F
S
M
E
K
L
G
S
A
G
K
P
L
F
S
C
E
I
K
I
----
E
R
D
-
G
---
Q
V
-
C
E
P
Y
E
-
H
--
G
E
I
M
V
K
-
G
P
N
V
M
K
S
Y
F
N
R
E
S
A
N
E
A
S
F
-
Q
-
N
-
G
W
L
K
T
G
D
L
G
Y
L
D
N
E
G
F
L
Y
V
L
D
R
R
S
D
L
I
I
S
G
G
E
N
I
Y
P
A
E
V
E
S
V
L
L
S
H
P
A
V
A
E
A
G
V
S
G
A
E
D
K
---
G
K
V
P
H
A
Y
L
V
-
L
H
K
--
P
----
V
S
A
---
G
E
L
T
D
Y
-
C
-
K
E
R
L
A
K
Y
K
-
I
P
A
K
F
F
V
L
D
R
L
P
R
N
A
S
N
K
L
L
R
N
Q
L
K
D
--------
22
PsiBlast_CBE
72.41
33%
-119
- C1 -
5BUQ
2
MENE_BACSU
B:
[9-481]
----
N
W
L
M
-
Q
R
A
Q
L
T
P
E
R
I
A
L
I
----
Y
----
E
D
Q
T
V
T
F
A
E
L
F
A
A
S
K
R
M
A
E
Q
L
A
A
H
S
V
R
K
G
D
T
A
A
I
L
L
Q
N
R
A
E
M
V
Y
A
V
H
A
C
F
L
L
G
V
K
A
V
L
L
N
T
K
L
S
T
H
E
R
L
F
Q
L
E
D
S
G
S
G
F
L
L
T
D
S
S
---------
F
E
----------
K
K
-
E
--
Y
E
H
I
V
Q
T
I
----
D
-
V
D
---
E
L
M
-------
K
E
A
A
E
-
E
-----
I
-
E
-------
I
E
A
Y
M
----
Q
M
--
D
A
T
A
T
L
M
Y
T
S
----
K
P
K
G
V
Q
Q
T
F
G
N
H
--
Y
F
S
A
V
S
----
S
A
-
L
N
---
L
G
-------
I
T
E
-
Q
D
R
W
L
-
I
A
L
-
P
L
F
H
I
S
G
L
----
S
A
L
-
F
K
S
V
I
Y
-
G
M
T
-
V
V
L
H
Q
R
--
F
S
--
V
S
D
V
L
H
S
I
N
R
H
E
V
T
M
I
S
A
V
Q
T
M
L
A
S
L
L
E
E
T
N
R
C
P
E
---------
S
I
R
C
I
L
L
G
G
G
P
A
P
L
P
L
L
E
-
E
C
R
-
E
-
K
--
G
-
F
P
-
V
F
Q
S
Y
G
M
T
E
T
C
---------
S
Q
I
V
T
L
S
P
---
E
F
S
M
E
K
L
G
S
A
G
K
P
L
F
S
C
E
I
K
I
----
E
R
D
-
G
---
Q
V
-
C
E
P
Y
E
-
H
--
G
E
I
M
V
K
-
G
P
N
V
M
K
S
Y
F
N
R
E
S
A
N
E
A
S
F
-
Q
-
N
-
G
W
L
K
T
G
D
L
G
Y
L
D
N
E
G
F
L
Y
V
L
D
---
D
L
I
I
S
G
G
E
N
I
Y
P
A
E
V
E
S
V
L
L
S
H
P
A
V
A
E
A
G
V
S
G
A
E
D
K
-----
V
P
H
A
Y
L
V
-
L
H
K
--
P
----
V
S
A
---
G
E
L
T
D
Y
-
C
-
K
E
R
L
A
K
Y
K
-
I
P
A
K
F
F
V
L
D
R
L
P
R
N
A
S
N
K
L
L
R
N
Q
L
K
D
--------
7
PsiBlast_PDB
70.39
32%
-115
- C1 -
1ULT
1
LCFCS_THET8
A:
[47-535]
----------------------------------
R
T
T
Y
A
E
V
Y
Q
R
A
R
R
L
M
G
G
L
R
A
L
G
V
G
V
G
D
R
V
A
T
L
G
F
N
H
F
R
H
L
E
A
Y
F
A
V
P
G
M
G
A
V
L
H
T
A
N
P
R
L
S
P
K
E
I
A
Y
I
L
N
H
A
E
D
K
V
L
L
F
D
P
N
L
L
P
L
V
E
A
I
R
G
E
----------
L
K
------
T
V
Q
H
F
V
----
V
-
M
D
---
E
K
A
PEGYLAY
E
E
A
L
G
-
E
-----
E
-
A
-------
D
P
V
R
V
PERA
A
C
G
------
M
A
Y
T
T
G
T
T
G
L
P
K
G
V
V
Y
S
H
R
A
L
V
L
H
S
L
A
A
S
----
L
V
-
D
G
---
T
A
-------
L
S
E
-
K
D
V
V
L
-
P
V
V
-
P
M
F
H
V
N
A
W
----
C
L
P
-
Y
A
A
T
L
V
-
G
A
K
Q
V
L
P
G
P
R
--
L
D
--
P
A
S
L
V
E
L
F
D
G
E
G
V
T
F
T
A
G
V
P
T
V
W
L
A
L
----
A
D
Y
L
E
S
--
T
G
H
R
L
K
T
L
R
R
L
V
V
G
G
S
A
A
P
R
S
L
I
A
-
R
F
E
-
R
-
M
--
G
-
V
E
-
V
R
Q
G
Y
G
L
T
E
T
S
PVV
V
Q
N
F
V
K
S
H
L
E
S
L
S
E
---
E
E
K
L
T
L
K
A
K
T
G
L
P
I
P
L
V
R
L
R
V
----
A
D
E
-
E
---
G
R
P
V
P
K
D
G
-
K
A
L
G
E
V
Q
L
K
-
G
P
W
I
T
G
G
Y
Y
G
N
E
E
A
T
R
S
A
L
-
T
P
D
-
G
F
F
R
T
G
D
I
A
V
W
D
E
E
G
Y
V
E
I
K
D
R
L
K
D
L
I
K
S
G
G
E
W
I
S
S
V
D
L
E
N
A
L
M
G
H
P
K
V
K
E
A
A
V
V
A
I
P
H
P
-
K
W
Q
E
R
P
L
A
V
V
V
-
P
R
G
E
-
K
----
P
T
P
---
E
E
L
N
E
H
L
L
-
K
A
G
F
A
K
W
Q
-
L
P
D
A
Y
V
F
A
E
E
I
P
R
T
S
A
G
K
F
L
K
R
A
L
R
E
Q
Y
K
-----
18
PsiBlast_PDB
69.87
29%
-100
- C1 -
3CW8
5
?
X:
[1-502]
M
Q
T
V
N
E
M
L
R
R
A
A
T
R
A
P
D
H
C
A
L
A
V
P
--
A
----
R
G
L
R
L
T
H
A
E
L
R
A
R
V
E
A
V
A
A
R
L
H
A
D
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
A
E
L
A
--------
E
L
I
K
R
G
E
M
T
A
A
V
I
A
V
G
R
Q
V
----------
A
D
-
A
--
I
F
Q
S
G
S
G
A
----
R
-
I
I
---
F
L
G
-------
D
L
V
R
D
-
G
-----
E
-
P
YSYGPPI
E
D
P
Q
R
----
E
P
A
--
Q
P
A
F
I
F
Y
T
S
G
T
T
G
L
P
K
A
A
I
I
P
Q
R
A
A
--
E
S
R
V
L
F
----
M
S
-
T
Q
---
V
G
-------
L
R
H
G
R
H
N
V
V
-
L
G
L
M
P
L
Y
H
V
V
G
F
----
F
A
V
-
L
V
A
A
L
A
L
D
G
T
-
Y
V
V
I
E
E
--
F
R
--
P
V
D
A
L
Q
L
V
Q
Q
E
Q
V
T
S
L
F
A
T
P
T
H
L
D
A
L
----
A
A
A
A
A
H
AG
S
S
L
K
L
D
S
L
R
H
V
T
F
A
G
A
T
M
P
D
A
V
L
E
T
V
H
Q
-
H
-
L
--
P
-
G
E
-
K
V
N
I
Y
G
T
T
E
A
M
---------
N
--
S
L
Y
M
R
---
Q
P
---
K
T
G
T
E
M
A
P
G
F
F
S
E
V
R
I
VRIG
G
G
V
-
D
---
E
I
-
V
A
N
G
E
-
E
--
G
E
L
I
V
A
A
S
D
S
A
F
V
G
Y
L
N
Q
P
E
A
T
A
E
K
L
-
Q
-
D
-
G
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
V
D
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
--
W
G
Q
S
V
T
A
C
V
V
-
P
R
L
G
-
E
T---
L
S
A
---
D
A
L
D
T
F
-
C
R
S
S
E
L
A
D
F
K
-
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
V
Q
Q
V
------
19
PsiBlast_PDB
69.78
29%
-99
- C1 -
3DLP
1
?
X:
[1-504]
M
Q
T
V
N
E
M
L
R
R
A
A
T
R
A
P
D
H
C
A
L
A
V
P
--
A
----
R
G
L
R
L
T
H
A
E
L
R
A
R
V
E
A
V
A
A
R
L
H
A
D
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
A
E
L
A
--------
E
L
I
K
R
G
E
M
T
A
A
V
I
A
V
G
R
Q
V
----------
A
D
-
A
--
I
F
Q
S
G
S
G
A
----
R
-
I
I
---
F
L
G
-------
D
L
V
R
D
-
G
-----
E
-
P
YSYGPPI
E
D
P
Q
R
----
E
P
A
--
Q
P
A
F
I
F
Y
T
S
G
T
T
G
L
P
K
A
A
I
I
P
Q
R
A
A
--
E
S
R
V
L
F
----
M
S
-
T
Q
---
V
G
-------
L
R
H
G
R
H
N
V
V
-
L
G
L
M
P
L
Y
H
V
V
G
F
----
F
A
V
-
L
V
A
A
L
A
L
D
G
T
-
Y
V
V
V
E
E
--
F
R
--
P
V
D
A
L
Q
L
V
Q
Q
E
Q
V
T
S
L
F
A
T
P
T
H
L
D
A
L
----
A
A
A
A
A
H
AG
S
S
L
K
L
D
S
L
R
H
V
T
F
A
G
A
T
M
P
D
A
V
L
E
T
V
H
Q
-
H
-
L
--
P
-
G
E
-
K
V
N
I
Y
G
T
T
E
A
M
---------
N
--
S
L
Y
M
R
---
Q
P
---
K
T
G
T
E
M
A
P
G
F
F
S
E
V
R
I
VRIG
G
G
V
-
D
---
E
I
-
V
A
N
G
E
-
E
--
G
E
L
I
V
A
A
S
D
S
A
F
V
G
Y
L
N
Q
P
Q
A
T
A
E
K
L
-
Q
-
D
-
G
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
V
P
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
-
R
W
G
Q
S
V
T
A
C
V
V
-
P
R
L
G
-
E
T---
L
S
A
---
D
A
L
D
T
F
-
C
R
S
S
E
L
A
D
F
K
-
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
V
Q
Q
V
S
S
----
8
PsiBlast_PDB
69.68
32%
-103
- C1 -
3A9U
-
?
A:
[51-534]
------------------------------------
T
Y
A
D
V
E
L
T
A
R
R
V
A
S
G
L
N
K
I
G
I
Q
Q
G
D
V
I
M
L
F
L
P
S
S
P
E
F
V
L
A
F
L
G
A
S
H
R
G
A
I
I
T
A
A
N
P
F
S
T
P
A
E
L
A
K
H
A
K
A
S
R
A
K
L
L
I
T
Q
A
C
Y
Y
E
K
V
K
D
F
A
R
E
-----------
D
-
V
--
K
V
M
C
V
D
S
A
PD--
G
-
C
L
---
H
F
S
-------
E
L
T
Q
A
-
D
-----
E
-
N
-------
E
A
P
Q
V
----
D
I
S
P
D
D
V
V
A
L
P
Y
S
S
G
T
T
G
L
P
K
G
V
M
L
T
H
K
G
L
-----
I
T
S
----
V
A
-
Q
Q
---
V
D
GDNPNLY
F
H
S
-
E
D
V
I
L
-
C
V
L
-
P
M
F
H
I
Y
A
L
----
N
S
I
-
M
L
C
G
L
R
V
G
A
P
-
I
L
I
M
P
K
--
F
E
--
I
G
S
L
L
G
L
I
E
K
Y
K
V
S
I
A
P
V
V
P
P
V
M
M
S
I
----
A
K
S
P
D
L
--
D
K
H
D
L
S
S
L
R
M
I
K
S
-------
E
L
E
D
-
T
V
R
-
A
-
K
F
P
Q
-
A
R
-
L
G
Q
G
Y
G
M
T
E
A
G
---------
P
V
L
A
M
C
L
A
FAK
E
P
F
D
I
K
P
G
A
C
G
T
V
V
R
N
A
E
M
K
I
----
V
D
P
-
E
TG-
A
S
-
L
P
R
N
Q
-
P
--
G
E
I
C
I
R
-
G
D
Q
I
M
K
G
Y
L
N
D
P
E
A
T
S
R
T
I
-
D
-
K
E
G
W
L
H
T
G
D
I
G
Y
I
D
D
D
D
E
L
F
I
V
D
R
L
K
E
L
I
K
Y
K
G
F
Q
V
A
P
A
E
L
E
A
L
L
I
A
H
P
E
I
S
D
A
A
V
V
G
L
K
D
E
-
D
A
G
E
V
P
V
A
F
V
V
K
S
E
K
S
-
Q
----
A
T
E
---
D
E
I
K
Q
Y
-
I
-
S
K
Q
V
I
F
Y
K
-
R
I
K
R
V
F
F
I
E
A
I
P
K
A
P
S
G
K
I
L
R
K
N
L
K
E
K
L
A
-----
20
PsiBlast_PDB
69.44
29%
-105
- C1 -
1T5D
2
?
X:
[1-504]
M
Q
T
V
N
E
M
L
R
R
A
A
T
R
A
P
D
H
C
A
L
A
V
P
--
A
----
R
G
L
R
L
T
H
A
E
L
R
A
R
V
E
A
V
A
A
R
L
H
A
D
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
A
E
L
A
--------
E
L
I
K
R
G
E
M
T
A
A
V
I
A
V
G
R
Q
V
----------
A
D
-
A
--
I
F
Q
S
G
S
G
A
----
R
-
I
I
---
F
L
G
-------
D
L
V
R
D
-
G
-----
E
-
P
YSYGPPI
E
D
P
Q
R
----
E
P
A
--
Q
P
A
F
I
F
Y
T
S
--
T
G
L
P
K
A
A
I
I
P
Q
R
A
A
--
E
S
R
V
L
F
----
M
S
-
T
Q
---
V
G
-------
L
R
H
G
R
H
N
V
V
-
L
G
L
M
P
L
Y
H
V
V
G
F
----
F
A
V
-
L
V
A
A
L
A
L
D
G
T
-
Y
V
V
V
E
E
--
F
R
--
P
V
D
A
L
Q
L
V
Q
Q
E
Q
V
T
S
L
F
A
T
P
T
H
L
D
A
L
----
A
A
A
A
A
H
AG
S
S
L
K
L
D
S
L
R
H
V
T
F
A
G
A
T
M
P
D
A
V
L
E
T
V
H
Q
-
H
-
L
--
P
-
G
E
-
K
V
N
I
Y
G
T
T
E
A
M
---------
N
--
S
L
Y
M
R
---
Q
P
---
K
T
G
T
E
M
A
P
G
F
F
S
E
V
R
I
VRIG
G
G
V
-
D
---
E
I
-
V
A
N
G
E
-
E
--
G
E
L
I
V
A
A
S
D
S
A
F
V
G
Y
L
N
Q
P
Q
A
T
A
E
K
L
-
Q
-
D
-
G
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
V
D
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
-
R
W
G
Q
S
V
T
A
C
V
V
-
P
R
L
G
-
E
T---
L
S
A
---
D
A
L
D
T
F
-
C
R
S
S
E
L
A
D
F
K
-
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
V
Q
Q
V
S
S
----
16
PsiBlast_PDB
69.21
29%
-100
- C1 -
2QW0
1
?
X:
[1-503]
M
Q
T
V
N
E
M
L
R
R
A
A
T
R
A
P
D
H
C
A
L
A
V
P
--
A
----
R
G
L
R
L
T
H
A
E
L
R
A
R
V
E
A
V
A
A
R
L
H
A
D
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
A
E
L
A
--------
E
L
I
K
R
G
E
M
T
A
A
V
I
A
V
--
Q
V
----------
A
D
-
A
--
I
F
Q
S
G
S
G
A
----
R
-
I
I
---
F
L
G
-------
D
L
V
R
D
-
G
-----
E
-
P
YSYGPPI
E
D
P
Q
R
----
E
P
A
--
Q
P
A
F
I
F
Y
T
S
---
G
L
P
K
A
A
I
I
P
Q
R
A
A
--
E
S
R
V
L
F
----
M
S
-
T
Q
---
V
G
-------
L
R
H
G
R
H
N
V
V
-
L
G
L
M
P
L
Y
H
V
V
G
F
----
F
A
V
-
L
V
A
A
L
A
L
D
G
T
-
Y
V
V
V
E
E
--
F
R
--
P
V
D
A
L
Q
L
V
Q
Q
E
Q
V
T
S
L
F
A
T
P
T
H
L
D
A
L
----
A
A
A
A
A
H
AG
S
S
L
K
L
D
S
L
R
H
V
T
F
A
G
A
T
M
P
D
A
V
L
E
T
V
H
Q
-
H
-
L
--
P
-
G
E
-
K
V
N
A
Y
G
T
T
E
A
M
---------
N
--
S
L
Y
M
R
---
Q
P
---
K
T
G
T
E
M
A
P
G
F
F
S
E
V
R
I
VRIG
G
G
V
-
D
---
E
I
-
V
A
N
G
E
-
E
--
G
E
L
I
V
A
A
S
D
S
A
F
V
G
Y
L
N
Q
P
Q
A
T
A
E
K
L
-
Q
-
D
-
G
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
V
D
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
-
R
W
G
Q
S
V
T
A
C
V
V
-
P
R
L
G
-
E
T---
L
S
A
---
D
A
L
D
T
F
-
C
R
S
S
E
L
A
D
F
K
-
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
V
Q
Q
V
S
-----
12
PsiBlast_PDB
68.86
29%
-100
- C1 -
2QVX
1
?
X:
[1-502]
M
Q
T
V
N
E
M
L
R
R
A
A
T
R
A
P
D
H
C
A
L
A
V
P
--
A
----
R
G
L
R
L
T
H
A
E
L
R
A
R
V
E
A
V
A
A
R
L
H
A
D
G
L
R
P
Q
Q
R
V
A
V
V
A
P
N
S
A
D
V
V
I
A
I
L
A
L
H
R
L
G
A
V
P
A
L
L
N
P
R
L
K
S
A
E
L
A
--------
E
L
I
K
R
G
E
M
T
A
A
V
I
A
V
G
R
Q
V
----------
A
D
-
A
--
I
F
Q
S
G
S
G
A
----
R
-
I
I
---
F
L
G
-------
D
L
V
R
D
-
G
-----
E
-
P
YSYGPPI
E
D
P
Q
R
----
E
P
A
--
Q
P
A
F
I
F
Y
T
S
--
T
G
L
P
K
A
A
I
I
P
Q
R
A
A
--
E
S
R
V
L
F
----
M
S
-
T
Q
---
V
G
-------
L
R
H
G
R
H
N
V
V
-
L
G
L
M
P
L
Y
H
V
V
G
F
----
F
A
V
-
L
V
A
A
L
A
L
D
G
T
-
Y
V
V
V
E
E
--
F
R
--
P
V
D
A
L
Q
L
V
Q
Q
E
Q
V
T
S
L
F
A
T
P
T
H
L
D
A
L
----
A
A
A
A
A
H
AG
S
S
L
K
L
D
S
L
R
H
V
T
F
A
G
A
T
M
P
D
A
V
L
E
T
V
H
Q
-
H
-
L
--
P
-
G
E
-
K
V
N
G
Y
G
T
T
E
A
M
---------
N
--
S
L
Y
M
R
---
Q
P
---
K
T
G
T
E
M
A
P
G
F
F
S
E
V
R
I
VRIG
G
G
V
-
D
---
E
I
-
V
A
N
G
E
-
E
--
G
E
L
I
V
A
A
S
D
S
A
F
V
G
Y
L
N
Q
P
Q
A
T
A
E
K
L
-
Q
-
D
-
G
W
Y
R
T
S
D
V
A
V
W
T
P
E
G
T
V
R
I
L
G
R
V
D
D
M
I
I
S
G
G
E
N
I
H
P
S
E
I
E
R
V
L
G
T
A
P
G
V
T
E
V
V
V
I
G
L
A
D
Q
-
R
W
G
Q
S
V
T
A
C
V
V
-
P
R
L
G
-
E
T---
L
S
A
---
D
A
L
D
T
F
-
C
R
S
S
E
L
A
D
F
K
-
R
P
K
R
Y
F
I
L
D
Q
L
P
K
N
A
L
N
K
V
L
R
R
Q
L
V
Q
Q
V
------
21
PsiBlast_CBE
66.14
33%
-116
- C1 -
5BUS
4
MENE_BACSU
B:
[9-388]
----
N
W
L
M
-
Q
R
A
Q
L
T
P
E
R
I
A
L
I
----
Y
----
E
D
Q
T
V
T
F
A
E
L
F
A
A
S
K
R
M
A
E
Q
L
A
A
H
S
V
R
K
G
D
T
A
A
I
L
L
Q
N
R
A
E
M
V
Y
A
V
H
A
C
F
L
L
G
V
K
A
V
L
L
N
T
K
L
S
T
H
E
R
L
F
Q
L
E
D
S
G
S
G
F
L
L
T
D
S
S
---------
F
E
----------
K
K
-
E
--
Y
E
H
I
V
Q
T
I
----
D
-
V
D
---
E
L
M
-------
K
E
A
A
E
-
E
-----
I
-
E
-------
I
E
A
Y
M
----
Q
M
--
D
A
T
A
T
L
M
Y
T
S
G
T
T
G
K
P
K
G
V
Q
Q
T
F
G
N
H
--
Y
F
S
A
V
S
----
S
A
-
L
N
---
L
G
-------
I
T
E
-
Q
D
R
W
L
-
I
A
L
-
P
L
F
H
I
S
G
L
----
S
A
L
-
F
K
S
V
I
Y
-
G
M
T
-
V
V
L
H
Q
R
--
F
S
--
V
S
D
V
L
H
S
I
N
R
H
E
V
T
M
I
S
A
V
Q
T
M
L
A
S
L
L
E
E
T--
C
P
E
---------
S
I
R
C
I
L
L
G
G
G
P
-
P
L
P
L
L
E
-
E
C
R
-
E
-
K
--
G
-
F
P
-
V
F
Q
S
Y
G
M
T
E
T
C
---------
S
Q
I
V
T
L
S
P
---
E
F
S
M
E
K
L
G
S
A
G
K
P
L
F
S
C
E
I
K
I
----
E
R
D
-
G
---
Q
V
-
C
E
P
Y
E
-
H
--
G
E
I
M
V
K
-
G
P
N
V
M
K
S
Y
F
N
R
E
S
A
N
E
A
S
F
-
Q
-
N
-
G
W
L
K
T
G
D
L
G
Y
L
D
N
E
G
F
L
Y
V
L
D
R
R
S
D
L
-------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
65.93
32%
-107
- C1 -
1V25
2
LCFCS_THET8
B:
[47-535]
----------------------------------
R
T
T
Y
A
E
V
Y
Q
R
A
R
R
L
M
G
G
L
R
A
L
G
V
G
V
G
D
R
V
A
T
L
G
F
N
H
F
R
H
L
E
A
Y
F
A
V
P
G
M
G
A
V
L
H
T
A
N
P
R
L
S
P
K
E
I
A
Y
I
L
N
H
A
E
D
K
V
L
L
F
D
P
N
L
L
P
L
V
E
A
I
R
G
E
----------
L
K
------
T
V
Q
H
F
V
----
V
-
M
D
---
E
K
A
PEGYLAY
E
E
A
L
G
-
E
-----
E
-
A
-------
D
P
V
R
V
PERA
A
C
G
------
M
A
Y
T
T
G
T
T
G
L
P
K
G
V
V
Y
S
H
R
A
L
VL
H
S
L
A
A
S
----
L
V
-
D
G
---
T
A
-------
L
S
E
-
K
D
V
V
L
-
P
V
V
-
P
M
F
H
V
N
A
W
----
C
L
P
-
Y
A
A
T
L
V
-
G
A
K
Q
V
L
P
G
P
R
--
L
D
--
P
A
S
L
V
E
L
F
D
G
E
G
V
T
F
T
A
G
V
P
T
V
W
L
A
L
----
A
D
Y
L
E
S
--
T
G
H
R
L
K
T
L
R
R
L
V
V
G
G
S
A
A
P
R
S
L
I
A
-
R
F
E
-
R
-
M
--
G
-
V
E
-
V
R
Q
G
Y
G
L
T
E
T
S
PVVVQNFVK
S
H
L
E
S
L
S
E
---
E
E
K
L
T
L
K
A
K
T
G
L
P
I
P
L
V
R
L
R
V
----
A
D
E
-
E
---
G
R
P
V
P
K
D
G
-
K
AL
G
E
V
Q
L
K
-
G
P
W
I
T
G
G
Y
Y
G
N
E
E
A
T
R
S
A
L
-
T
P
D
-
G
F
F
R
T
G
D
I
A
V
W
D
E
E
G
Y
V
E
I
K
D
R
L
K
D
L
I
K
S
G
G
E
W
I
S
S
V
D
L
E
N
A
L
M
G
H
-----
A
A
V
V
A
I
P
H
P
-
K
W
Q
E
R
P
L
A
V
----------------------
N
E
H
L
L
-
K
A
G
F
A
K
W
Q
-
L
P
D
A
Y
V
F
---------
G
K
F
L
K
R
A
L
R
E
Q
Y
K
-----