@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3127: (2016-05-17 )
MLKNAVLLACRAPSVHNSQPWRWVAESGSEHTTVHLFVNRHRTVPATDHSGRQAIISCGAVLDHLRIAMTAAHWQANITRFPQPNQPDQLATVEFSPIDHVTAGQRNRAQAILQRRTDRLPFDSPMYWHLFEPALRDAVDKDVAMLDVVSDDQRTRLVVASQLSEVLRRDDPYYHAELEWWTSPFVLAHGVPPDTLASDAERLRVDLGRDFPVRSYQNRRAELADDRSKVLVLSTPSDTRADALRCGEVLSTILLECTMAGMATCTLTHLIESSDSRDIVRGLTRQRGEPQALIRVGIAPPLAAVPAPTPRRPLDSVLQIRQTPEKGRNASDRNARETGWFSPP
Atome Classification :
(20 SA)
---------------------------------------------------------------------------------------------------------.........10........--20........30---........40........50.....-...60-........70-----........80-........90........100..---.....110.......120.---..--.....130.......140-----.-------.....-.---------------..150........160.......170...-------....180.------......190--........200.....-..210.......220........230....----------------------.----------------------.--------------------.-----------------------240----.........250.......260.......270.......280.----..--.--.-..290.......---300-....--...310...--....320.-----......330.......340...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------------------------------------------------------------------------------------------------------MLKN
A
V
L
L
A
CRAPSVHNSQ--P
W
R
W
V
AESGSE
H
---
T
T
V
H
L
F
V
NRHRTVPATDHSG
R
Q
A
I
I
-
S
C
G
A
V
-
L
D
H
L
R
I
A
M
T
A
-----
A
H
WQANITRF-PQPNQPD
Q
L
A
T
V
E
FSPIDHVTAG---QR
N
R
A
Q
A
I
L
Q
R
R
TDRLP-F---DS--P
M
Y
W
H
LF
E
P
A
L
R
D
A
V
D-------K-------D
V
A
M
L
-
D
---------------VVSD-DQ
R
T
R
L
V
V
A
S
Q
L
S
E
V
L
RRDDP
Y
Y
H
-------
A
E
L
E
WWTS------
P
F
V
L
AHGV---
P
P
D
T
L
A
S
D
A
E
R
L
R
V
D
L-GRDFP
V
R
S
Y
Q
N
R
R
-
A
E
LADDRS
K
V
L
V
L
STP----------------------S----------------------D--------------------
T
-----------------------
R
------
A
D
A
L
R
C
G
E
V
L
S
T
I
L
L
E
C
T
M
A
G
M
A
T
C
T
L
T
H
L
IESSDS
R
D
I
V
R
G
L
----
T
R--Q--R-G
E
P
Q
A
L
I
R
VGIA---PPL-AAVP--APTPRR
P
L
D
--
S
V
L
Q
I
RQT-----PEKGRNASDRNARETGW-FSPP
1
PsiBlast_PDB
95.04
48%
-81
- C7 -
2YMV
9
?
A:
[12-327]
----------------------------------------------------------------------------------------------------------
L
A
N
A
V
Q
L
A
A
R
A
P
S
L
H
N
T
Q
--
P
W
R
L
I
A
E
D
G
E
-------
L
K
L
F
L
D
P
S
R
V
V
R
S
T
D
R
S
S
R
E
A
V
M
-
S
C
G
V
L
-
L
D
H
L
R
V
A
L
A
A
-----
A
G
W
D
T
E
V
Q
R
F
-
P
N
P
N
D
R
D
H
L
A
T
L
S
F
R
P
L
Q
F
V
T
E
G
---
H
R
K
R
A
D
A
I
L
A
R
R
T
D
R
L
P
-
M
---
S
A
--
Y
V
D
W
D
A
F
E
T
L
L
R
A
R
L
G
-------
D
-------
G
P
V
H
M
-
D
---------------
T
L
G
E
-
D
V
R
E
E
V
A
E
A
A
A
L
T
E
S
L
R
L
Y
D
A
A
Y
H
-------
S
E
L
A
W
W
T
T
------
P
F
A
T
E
D
G
I
---
P
Q
T
A
L
I
S
A
E
E
S
E
R
V
A
V
-
S
R
D
F
P
V
A
P
H
S
S
R
R
-
P
A
L
N
N
D
A
A
T
I
V
V
L
S
T
D
----------------------
G
----------------------
Y
--------------------
S
-----------------------
R
------
E
D
A
L
D
A
G
E
G
L
S
K
V
L
L
E
C
T
M
S
G
L
A
T
C
P
V
T
H
V
T
E
L
H
T
S
R
D
I
I
G
R
L
----
I
V
--
R
--
D
-
A
C
P
Q
V
L
V
R
I
G
L
A
---
P
A
L
-
D
E
V
P
--
P
P
T
P
R
R
P
V
D
--
A
F
L
E
V
R
-----------------------------
43
Fugue
94.86
48%
-79
- C7 -
2YMV
9
?
A:
[3-329]
-------------------------------------------------------------------------------------------------SDTRLD
V
A
T
L
A
N
A
V
Q
L
A
A
R
A
P
S
L
H
N
T
Q
--
P
W
R
L
I
A
E
D
G
-------
E
L
K
L
F
L
D
P
S
R
V
V
R
S
T
D
R
S
S
R
E
-
A
V
M
S
C
G
V
L
-
L
D
H
L
R
V
A
L
A
A
-----
A
G
W
D
T
E
V
Q
R
F
-
P
N
P
N
D
R
D
H
L
A
T
L
S
F
R
P
L
Q
F
V
T
E
G
---
H
R
K
R
A
D
A
I
L
A
R
R
T
D
R
L
P
M
S
---
A
---
Y
V
D
W
D
A
F
E
T
L
L
R
A
R
L
G
-------
D
-------
G
P
V
-
H
M
D
---------------
T
L
G
E
-
D
V
R
E
E
V
A
E
A
A
A
L
T
E
S
L
R
L
Y
D
A
A
Y
H
-------
S
E
L
A
W
W
T
T
------
P
F
A
T
E
D
G
I
---
P
Q
T
A
L
I
S
A
E
E
S
E
R
V
A
V
-
S
R
D
F
P
V
A
P
H
S
S
R
R
-
P
A
L
N
N
D
A
A
T
I
V
V
L
S
T
D
----------------------
G
----------------------
Y
--------------------
S
-----------------------
R
------
E
D
A
L
D
A
G
E
G
L
S
K
V
L
L
E
C
T
M
S
G
L
A
T
C
P
V
T
H
V
T
E
L
H
T
S
R
D
I
I
G
R
L
----
I
V
--
R
--
D
-
A
C
P
Q
V
L
V
R
I
G
L
A
---
P
A
L
-
D
E
V
P
--
P
P
T
P
R
R
P
V
D
--
A
F
L
E
V
R
P
R
---------------------------
23
HHSearch
94.23
48%
-83
- C7 -
2YMV
9
?
A:
[11-328]
---------------------------------------------------------------------------------------------------------
T
L
A
N
A
V
Q
L
A
A
R
A
P
S
L
H
N
T
Q
--
P
W
R
L
I
A
-
E
D
G
E
------
L
K
L
F
L
D
P
S
R
V
V
R
S
T
D
R
S
S
R
E
A
V
M
-
S
C
G
V
L
-
L
D
H
L
R
V
A
L
A
A
-----
A
G
W
D
T
E
V
Q
R
F
-
P
N
P
N
D
R
D
H
L
A
T
L
S
F
R
P
L
Q
F
V
T
E
G
---
H
R
K
R
A
D
A
I
L
A
R
R
T
D
R
L
P
-
M
---
S
A
--
Y
V
D
W
D
A
F
E
T
L
L
R
A
R
L
G
-------
D
-------
G
P
V
H
M
-
D
---------------
T
L
G
E
-
D
V
R
E
E
V
A
E
A
A
A
L
T
E
S
L
R
L
Y
D
A
A
Y
H
-------
S
E
L
A
W
W
T
T
------
P
F
A
T
E
D
G
I
---
P
Q
T
A
L
I
S
A
E
E
S
E
R
V
A
V
-
S
R
D
F
P
V
A
P
-
H
S
S
R
R
P
A
L
N
N
D
A
A
T
I
V
V
L
S
T
D
----------------------
G
----------------------
Y
--------------------
S
-----------------------
R
------
E
D
A
L
D
A
G
E
G
L
S
K
V
L
L
E
C
T
M
S
G
L
A
T
C
P
V
T
H
V
T
E
L
H
T
S
R
D
I
I
G
R
L
----
I
V
--
R
--
D
-
A
C
P
Q
V
L
V
R
I
G
L
A
---
P
A
L
D
E
-
V
P
--
P
P
T
P
R
R
P
V
D
--
A
F
L
E
V
R
P
----------------------------
37
HHSearch
56.06
20%
-76
* C7 *
1BKJ
3
FRP_VIBHA
A:
[2-193]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
T
I
E
T
I
L
A
H
R
S
I
R
K
--
F
---
T
A
--
V
P
I
T
D
E
Q
R
Q
T
I
I
Q
A
G
L
-------
A
ASSSSML
Q
V
V
S
I
-
V
---------------
R
V
T
D
S
E
K
R
N
E
L
A
Q
F
A
G
N
Q
---------------------------------------------------------------------------
A
Y
V
E
S
A
A
E
F
L
V
F
C
I
D
----------------------
Y
----------------------
Q
--------------------
R
H
A
T
I
NPDVQADF
T
E
L
T
-------
L
------
I
G
A
V
D
S
G
I
M
A
Q
N
C
L
L
A
A
E
S
M
G
L
G
G
V
Y
I
G
G
L
R
N
S
A
---
A
Q
V
D
E
L
----
L
G
LP
E
--
N
-
S
A
V
L
F
G
M
C
L
G
H
P
---
D
Q
N
----
P
--
E
V
K
P
R
L
P
A
H
--
V
V
V
H
E
N
Q
Y
-----
Q
E
L
-------------------
38
HHSearch
54.95
18%
-67
- C7 -
3E39
6
?
A:
[5-176]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
P
V
L
Q
A
I
R
Q
R
R
S
I
R
R
--
Y
---
T
D
--
E
A
V
S
D
E
A
V
R
L
I
L
E
A
G
I
-------
W
APSGLNN
Q
P
C
R
F
-
L
---------------
V
I
R
A
D
D
P
R
C
D
I
L
A
A
H
T
R
---------------------------------------------------
Y
-----------------------
G
H
I
V
R
G
A
K
V
I
I
L
V
F
L
D
----------------------
R
----------------------
E
AMYN----------------
E
-----------------------
V
------
K
D
H
Q
A
A
G
A
A
V
Q
N
M
L
L
A
A
H
A
L
Q
L
G
A
V
W
L
G
E
I
I
N
Q
A
---
A
T
L
L
P
A
----
L
A
L-
D
PA
R
-
L
S
F
E
A
A
I
A
A
G
H
P
---
A
Q
N
-------
G
S
S
S
R
R
P
L
A
--
E
L
L
L
E
E
P
F
-----
P
Q
--------------------
28
HHSearch
53.42
15%
-88
- C7 -
3N2S
3
NFRA1_BACSU
A:
[2-190]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
N
T
I
E
T
I
L
N
H
R
S
I
R
S
--
F
---
T
D
--
Q
L
L
T
A
E
E
I
D
T
L
V
K
S
A
Q
A
ASTSSY
V
-------
Q
A
Y
S
I
-
I
---------------
G
V
S
D
P
E
K
K
R
E
L
S
V
L
A
G
N
Q
-
P
Y
--------------------------------------------------------------------------
V
E
K
N
G
H
F
F
V
F
C
A
D
L
Y
R
H
Q
Q
L
A
E
E
K
GEHI
S
E
L
L
E
N
T
E
----------------------
M
--------------------
F
-----------------------
M
------
V
S
L
I
D
A
A
L
A
A
Q
N
M
S
I
A
A
E
S
M
G
L
G
I
C
Y
I
G
G
I
R
N
E
L
---
D
K
V
T
E
V
----
L
Q
TP
D
--
H
-
V
L
P
L
F
G
L
A
V
G
H
P
---
A
N
----
L
S
--
G
K
K
P
R
L
P
K
Q
--
A
V
Y
H
E
N
T
Y
-----
N
V
N
-------------------
30
HHSearch
52.42
19%
-59
- C7 -
4XOM
1
?
A:
[8-206]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
---
E
L
G
R
Q
Q
A
Q
L
L
R
R
S
V
R
R
--
F
---
S
T
--
D
P
V
P
G
D
L
V
E
A
A
V
A
E
A
L
TAPAPHH
T
-------
R
P
T
R
F
-
V
---------------
W
L
Q
T
P
A
I
R
A
R
L
L
D
R
M
K
D
K
W
R
S
D
L
T
S
D
------------------------------
G
L
---
P
A
D
A
I
--
E
R
R
-----------
V
A
------
R
-
G
Q
I
L
Y
D
A
P
E
V
V
I
P
M
L
V
----------------------
P
----------------------
D
G
A
H
S
Y
PD
A
A
R
T
D
A
E
------
H
-----------------------
T
------
M
F
T
V
A
V
G
A
A
V
Q
A
L
L
V
A
L
A
V
R
G
L
G
S
C
W
I
G
S
T
I
F
A
A
---
D
L
V
R
D
E
----
L
D
LP
V
--
D
-
W
E
P
L
G
A
I
A
I
G
Y
A
---
D
E
----
P
S
--
G
L
R
D
P
V
P
A
A
--
D
L
L
I
L
------------------------------
29
HHSearch
51.59
14%
-75
- C7 -
1ZCH
2
NFRA2_BACSU
A:
[2-190]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
V
I
K
S
L
T
D
H
R
S
I
R
S
--
Y
---
T
D
--
E
P
V
A
Q
E
Q
L
D
Q
I
I
E
A
V
Q
-------
S
APSSING
Q
Q
V
T
V
-
I
---------------
T
V
Q
D
K
E
R
K
K
K
I
S
E
L
A
G
G
Q
P
---------------------------------------------------------------------------
W
I
D
Q
A
P
V
F
L
L
F
C
A
D
----------------------
F
N
R
A
K
I
A
L
EDLHDFKMEITNGL
E
S
--------------------
V
-----------------------
L
------
V
G
A
V
D
A
G
I
A
L
G
T
A
T
A
A
A
E
S
L
G
L
G
T
V
P
I
G
A
V
R
G
N
P
---
Q
E
L
I
E
L
----
L
E
LP
K
--
Y
-
V
F
P
L
S
G
L
V
I
G
H
P
---
A
D
R
----
S
--
A
K
K
P
R
L
P
Q
E
--
A
V
N
H
Q
E
T
Y
-----
L
N
Q
-------------------
36
HHSearch
50.36
17%
-69
- C7 -
3M5K
4
?
A:
[5-171]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
N
Q
T
L
E
T
I
L
N
R
K
S
V
R
-
K
-
Y
---
K
D
--
R
P
V
E
K
E
K
I
D
K
L
I
R
A
G
M
A
A
P
S
S
RD
R
-------
R
P
W
E
F
-
I
---------------
I
V
T
D
R
K
A
L
D
T
M
A
E
G
L
P
F
---------------------------------------------------------------------------
A
R
M
L
K
E
T
R
Q
A
I
V
V
C
G
D
----------------------
T
----------------------
I
KS------------------
S
-----------------------
N
------
A
W
F
L
D
C
S
A
A
S
Q
N
L
L
L
A
A
E
S
M
G
L
G
A
V
W
T
A
V
Y
P
Y
P
-
D
R
I
E
I
V
R
K
E
----
L
R
LP
D
--
H
-
I
M
P
L
N
V
I
P
V
G
Y
P
---
M
Q
K
----
E
--
T
P
K
N
K
Y
N
V
Q
--
Q
I
H
-
H
N
G
----------------------------
31
HHSearch
50.26
13%
-56
- C7 -
3K6H
5
?
A:
[7-196]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
---
D
I
K
L
L
D
Y
L
R
V
R
R
S
T
P
A
--
L
---
Q
L
S
E
P
G
P
S
K
G
E
I
E
E
I
L
R
L
A
V
RVPDHGK
L
-------
A
P
W
R
F
-
V
---------------
V
Y
R
G
E
E
R
-
V
R
L
S
E
A
A
L
R
I
A
L
E
K
N
P
D
L
--------------
D
L
---------------------
Q
Q
Q
--
E
--------------
A
------
E
-
R
T
R
F
T
R
A
P
V
V
I
A
V
I
S
T
----------------------
A
----------------------
K
--------------------
P
-----------------------
H
FKIP
E
W
E
Q
V
M
S
A
G
A
V
C
L
N
V
I
F
A
A
N
A
S
G
F
A
A
N
W
L
T
E
W
L
A
F
D
---
P
A
F
L
A
E
----
I
G
VS
A
--
E
-
E
K
V
A
G
Y
I
H
I
G
S
T
---
T
F
P
----
P
--
V
E
R
P
R
P
E
L
A
--
D
V
V
T
W
V
G
D
---------------------------
41
HHSearch
49.64
15%
-70
- C7 -
3G14
5
?
A:
[2-182]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
F
Y
E
V
I
K
K
R
K
S
I
K
K
--
F
---
E
Q
--
T
A
I
D
R
D
K
L
L
K
I
I
D
M
A
M
-------
R
APSWKNK
T
P
Y
K
F
-
I
---------------
V
V
E
S
D
K
L
K
L
D
I
A
N
A
I
E
N
K
T
S
--------------------------------------------------
A
-------------------
A
-
S
E
A
V
L
N
S
P
M
T
I
V
A
V
A
N
----------------------
P
----------------------
E
ESGDVSG-------------
K
-----------------------
E
------
I
Y
L
I
D
T
A
I
A
M
E
H
I
V
L
G
A
T
D
E
G
Y
G
T
C
W
I
A
A
F
N
E
-----
N
K
I
K
E
A
----
L
K
IP
D
--
N
-
L
R
V
V
A
L
T
P
L
G
V
P
---
K
D
------------
K
K
D
M
D
--
E
Y
L
Y
I
D
K
W
-----
G
T
S
F
------------------
32
HHSearch
49.49
14%
-65
- C7 -
3GFA
8
?
A:
[2-197]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
S
D
S
I
S
K
R
R
S
I
R
K
--
Y
---
K
N
--
Q
S
I
S
H
E
T
I
E
K
I
I
E
A
G
I
-------
N
APSSKNR
Q
P
W
R
F
-
V
---------------
V
I
T
E
K
E
K
E
S
M
L
K
A
M
S
K
G
I
Q
N
E
I
N
D
N
G
-
L
----------
L
P
G
S
R
Q
----------------------
H
I
A
G
A
N
-----------------
Y
T
-
V
E
I
M
K
Q
A
P
V
T
I
F
I
L
N
I
----------------------
L
----------------------
G
--------------------
K
SPL
E
K
L
S
P
E
E
R
F
Y
E
---------
M
------
A
N
M
Q
S
I
G
A
A
I
Q
N
M
S
L
T
A
V
E
L
G
L
G
S
L
W
I
C
D
V
Y
F
A
Y
---
R
E
L
C
E
W
----
L
N
--
T
--
D
-
S
Q
L
V
A
A
I
S
L
G
Y
P
---
D
E
E
----
P
--
S
R
R
P
R
L
Q
L
S
--
D
V
T
E
W
------------------------------
33
HHSearch
49.47
16%
-77
- C7 -
3GB5
3
IYD1_MOUSE
A:
[52-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
R
---
S
Q
E
F
Y
E
L
L
N
K
R
R
S
V
R
F
--
I
---
S
S
--
E
H
V
P
M
E
V
I
E
N
V
I
K
A
A
G
T
A
P
S
G
AH
T
-------
E
P
W
T
F
-
V
---------------
V
V
K
D
P
D
M
K
H
K
I
R
E
I
I
E
E
E
E
E
I
-----------------------------------------------------------------------
K
E
Y
L
D
T
A
P
V
L
I
L
I
F
K
Q
----------------------
V
--------------------------------------------------------------------------
Y
N
E
I
S
V
S
I
A
C
G
L
L
L
A
A
L
Q
N
A
G
L
V
T
V
T
T
T
P
L
N
C
----
G
P
R
L
R
V
L
----
L
G
RP
S
--
H
-
E
K
L
L
V
L
L
P
V
G
Y
P
---
S
R
D
-
A
-
T
V
--
P
D
L
K
R
K
A
L
D
--
Q
I
M
V
T
V
-----------------------------
27
HHSearch
49.46
15%
-73
- C7 -
3EOF
2
?
A:
[2-187]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
M
D
T
V
K
N
R
R
T
I
R
K
--
Y
---
Q
Q
--
K
D
I
T
P
D
L
L
N
D
L
L
E
T
S
F
-------
R
ASTMGGM
Q
L
Y
S
V
-
V
---------------
V
T
R
D
A
E
K
K
E
I
L
S
P
A
H
F
N
---------------------------------------------------------------------------
Q
P
M
V
K
E
A
P
V
V
L
T
F
C
A
D
----------------------
F
----------------------
R
R
F
C
K
Y
C
Q
E
R
NAVPGYGN
L
M
S
F
-----------------------
L
------
N
A
A
M
D
T
L
L
V
A
Q
T
F
C
T
L
A
E
E
A
G
L
G
I
C
Y
L
G
T
T
T
Y
N
P
---
Q
M
I
I
D
A
----
L
H
LP
E
--
L
-
V
F
P
I
T
T
V
T
V
G
Y
P
---
A
E
S
----
P
--
K
Q
V
D
R
L
P
I
E
--
G
I
I
H
E
E
S
Y
-----
H
D
Y
T
------------------
50
Fugue
48.92
18%
-36
* C6 *
4JE5
5
ARO8_YEAST
A:
[5-502]
T
L
P
E
S
K
D
FSYLFS
D
E
T
N
A
RKPSPLKLFQDPNIIFLGGGLPLKDYFPWDN
L
S
V
D
S
P
K
P
PFPQGIGAPIDEQN
C
I
K
Y
T
V
N
KDYADKSANPSNDIP
L
S
R
A
L
QYGFSAG
Q
P
E
L
L
N
F
I
R
D
H
T
K
I
I
H
D
L
K
YK
D
W
D
V
L
A
T
A
G
N
T
N
A
W
E
S
T
L
R
V
F
C
N
R
G
D
V
I
L
V
E
A
H
S
F
S
S
S
L
A
-
S
A
E
A
Q
G
V
I
T
F
P
V
P
I
D
A
DGII
P
E
K
L
A
K
V
M
E
N
W
T
P
G
A
P
K
P
K
L
L
Y
T
I
---
P
T
G
Q
N
P
T
G
T
S
I
A
D
H
R
K
E
A
I
Y
K
I
A
Q
K
Y
D
F
-
L
I
V
E
D
E
--
P
Y
Y
F
L
Q
M
N
P
Y
I
K
D
L
K
E
-------
R
-------
E
K
A
Q
S
-
S
PKQD
H
D
E
F
L
K
S
L
A
N
T
F
L
S
L
-
D
T
E
G
R
V
I
R
M
D
S
F
S
K
V
L
A
P
G
T
R
------------
L
G
W
I
T
G
S
SKIL
K
P
Y
L
S
L
H
E
M
T
IQ
A
P
A
G
F
T
Q
V
L
V
N
A
T
L
S
R
W
G
Q
K
G
Y
L
D
W
L
L
G
L
R
-
H
E
Y
T
L
K
R
D
C
A
I
D
A
L
Y
K
----------------------
Y
----------------------
L
--------------------
P
-----------------------
Q
------
S
D
A
F
V
I
N
P
P
I
A
G
M
F
F
T
V
N
I
D
A
S
V
H
P
E
F
K
T
K
Y
-
N
S
D
P
Y
Q
L
E
Q
S
L
----
Y
H
--
K
--
V
-
V
E
R
G
V
L
V
V
P
G
S
W
F
K
S
E
G
E
-
T
E
P
P
--
Q
P
A
E
S
K
E
V
S
NP
N
I
I
F
F
R
G
T
YAAVS
P
E
K
L
T
E
G
L
K
R
L
G
D
T
L
Y
E
E
F
G
I
S
24
HHSearch
47.77
11%
-63
- C7 -
3EO8
8
?
A:
[2-218]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
E
L
Q
D
T
I
F
K
R
Q
S
V
R
K
--
F
---
K
N
--
Q
D
V
S
D
E
D
I
L
K
M
I
K
A
A
G
-------
A
APSGKNI
Q
N
W
H
F
-
V
---------------
V
I
K
R
R
D
L
M
E
K
I
A
D
V
I
T
K
K
Q
Q
E
I
L
V
E
M
D
K
----------
V
--
S
-------------
V
D
------
K
A
N
R
F
R
K
------
F
-
V
----
K
N
-----
F
-
T
L
F
Y
L
K
A
P
V
L
V
L
V
F
T
K
----------------------
V
----------------------
Y
--------------------
N
PSG
Y
Y
E
L
E
L
I
DAP
K
E
T
I
D
K
L
F
IR
N
------
P
G
M
Q
S
L
G
A
A
I
E
N
F
T
L
S
A
I
E
L
G
Y
G
S
C
W
L
T
S
Q
N
Y
A
A
D
---
E
I
E
A
V
L
E
A
E
T
G
F-
E
K-
G
E
Y
F
L
G
A
M
L
A
L
G
V
P
---
E
D
N
----
L
--
K
S
P
S
K
K
P
V
E
--
E
I
C
T
F
I
-----------------------------
25
HHSearch
47.16
20%
-50
- C7 -
2WZV
6
NFNB_MYCS2
A:
[14-234]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
L
---
A
Q
A
A
E
R
L
I
K
G
R
R
A
V
R
-
A
-
F
---
R
P
--
D
E
V
P
E
E
T
M
R
A
V
F
E
L
A
G
H
APSNSN
T
-------
Q
P
W
H
V
-
E
---------------
V
V
S
G
-
A
A
R
D
R
L
A
E
A
L
V
T
A
H
A
E
E
R
V
T
V
D
F
P
YREGLFQ
G
V
L
Q
E
R
R
A
------
D
F
--
G
S
R
L
---
Y
A
A
-
L
G
I
A
R
D
Q
--
T
D
L
-
L
Q
G
-------
Y
N
T
E
S
L
R
F
Y
G
A
P
H
V
A
M
L
F
A
P
----------------------
N
----------------------
N
T-------------------
E
-----------------------
A
------
R
I
A
G
D
M
G
I
Y
A
Q
T
L
M
L
A
M
T
A
H
G
I
A
S
C
P
Q
A
L
L
S
F
Y
A
---
D
T
V
R
A
E
----
L
G
V-
E
--
N
-
R
K
L
L
M
G
I
S
F
G
Y
A
---
D
D
T
-
A
-
A
V
NG
V
R
I
P
R
A
G
L
S
--
E
T
T
R
F
S
-----------------------------
34
HHSearch
46.62
9%
-67
- C7 -
3BM1
2
YDJA_ECOLI
A:
[1-182]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
A
L
E
L
L
I
N
R
R
S
A
S
-
R
-
L
---
A
E
--
P
A
P
T
G
E
Q
L
Q
N
I
L
R
A
G
M
R
APDHKS
M
-------
Q
P
W
H
F
-
F
---------------
V
I
E
G
-
E
G
R
E
R
F
S
A
V
L
E
Q
G
A
I
A
A
G
S
D
D
K
--------------
A
-------------------------
I
D
--------------
K
------
A
-
R
N
A
P
F
R
A
P
L
I
I
T
V
V
A
K
----------------------
C
----------------------
E
--------------------
E
-----------------------
N
HKVP
R
W
E
Q
E
M
S
A
G
C
A
V
M
A
M
Q
M
A
A
V
A
Q
G
F
G
G
I
W
R
S
G
A
L
T
E
S
---
P
V
V
R
E
A
----
F
G
CR
E
--
Q
-
D
K
I
V
G
F
L
Y
L
G
T
P
---
Q
L
-----------
N
V
P
D
P
T
--
P
F
V
T
Y
------------------------------
26
HHSearch
46.44
14%
-68
- C7 -
1F5V
2
NFSA_ECOLI
A:
[2-185]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
P
T
I
E
L
I
C
G
H
R
S
I
R
H
--
F
---
T
D
--
E
P
I
S
E
A
Q
R
E
A
I
I
N
S
A
R
-------
A
TSSSSFL
Q
C
S
S
I
-
I
---------------
R
I
T
D
K
A
L
R
E
E
L
V
T
L
T
G
G
Q
K
---------------------------------------------------------------------------
H
V
A
Q
A
A
E
F
W
V
F
C
A
D
----------------------
F
----------------------
N
R
H
L
Q
I
C
P
DAQLGL
A
E
Q
----
L
-----------------------
L
------
L
G
V
V
D
T
A
M
M
A
Q
N
A
L
I
A
A
E
S
L
G
L
G
G
V
Y
I
G
G
L
R
N
N
I
---
E
A
V
T
K
L
----
L
K
LP
Q
--
H
-
V
L
P
L
F
G
L
C
L
G
W
P
---
A
D
N
----
P
--
D
L
K
P
R
L
P
A
S
--
I
L
V
H
E
N
S
Y
-----
Q
P
L
D
------------------
40
HHSearch
46.42
14%
-63
- C7 -
2I7H
3
?
A:
[6-188]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
---
Y
T
S
I
A
N
V
I
K
E
R
R
S
V
R
-
T
-
F
---
T
D
--
K
A
V
E
K
D
L
L
I
E
L
L
N
D
A
T
-------
W
APNHKHR
E
P
W
N
C
-
K
---------------
L
Y
I
G
-
E
G
R
K
K
L
V
D
A
V
L
N
S
F
T
E
E
E
---------------
R
A
K
R
G
-------------------------
K
--------------
I
L
-------
S
D
R
F
L
S
T
P
A
Q
I
V
V
Y
M
N
----------------------
E
----------------------
D
--------------------
P
-----------------------
R
Q
I
Q
R
D
-
E
D
Y
A
A
T
C
A
F
M
Q
N
F
Q
L
L
A
W
E
R
G
L
G
C
V
W
K
S
G
G
L
N
Y
N
---
P
L
F
I
E
G
----
I
G
LT
R
--
G
-
Q
R
I
V
G
I
L
H
I
G
Y
F
---
D
K
A
----
P
--
E
G
K
A
R
T
P
I
T
--
E
K
M
E
I
I
E
----------------------------