@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3140: (2016-05-17 )
MAINLELPRKLQAIIVKTHQGAAEMMRPIARKYDLKEHAYPVELDTLINLFEGAAESFNFAGAHSLRDEDEGKDENHNGANMAAVVQTMEASWGDVAMMLSLPYQGLGNAAISAVATDEQLERLGKVWAAMAITEPEFGSDSAAVSTTATLDGDEYVINGEKIFVTAGSRATHIVVWATLDKSLGRPAIKSFIVPREHPGVTVERLEHKLGIKGSDTAVIRFDNARIPKGNLLGNPEIEVGKGFAGVMETFDNTRPIVAAMAVGIGRAALEEIRSVLTGAGVEISYDKPSHTQSAAAAEFLRMEADWEASYLLSLRAAWQADNNIPNSKEASMSKAKAGRMASDVTCKTVELAGTTGYSEQSLLEKWARDSKILDIFEGTQQIQQLVVARRLLGLSSSELK
Atome Classification :
(36 SA)
.........10........20........30........40...-.....50........60........70........80..---......90....--....100.......110.......120.------.------..-----...130.......140.......150..-.....160.......170.......180--..---..----....190---.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300-..---...----..310.......320.......330.......340.......350.......360.......370.......380.......390.......400
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
A
INLELP
R
K
L
Q
A
I
I
VKTHQ
G
A
A
E
M
M
R
P
I
A
R
KYDLKEHAYP
V
E
L
-
D
T
L
I
N
L
F
E
G
A
A
E
SFNFAGAHSLRDEDEGKDENHNG
A
N
M
A
---
A
V
V
Q
T
M
EASWG
D
--
V
A
M
M
LSLPYQGL
G
N
A
A
I
S
AVA
T
D
E
Q
L
E
R
------
L
------
G
K
-----
V
W
A
A
MAITEPEFGSDSA
A
V
S
T
T
A
TLDGD-
E
Y
V
ING
E
K
I
F
V
TAGSR
A
T
H
I
V
V
W
A
T
L
D
---
K
S---LG----
R
P
A
I
K
S
F
---IVPREHPG
V
T
V
E
R
L
E
H
K
LGIKGS
D
T
A
V
I
R
FDNARIPKGNLLGNP
E
I
E
VG
K
G
F
A
G
V
M
E
T
FDNT
R
P
I
V
A
A
M
A
V
G
I
G
R
A
A
L
E
E
I
R
S
V
LTGAG
V
E
I
SYDKPSHT
Q
S
A
A
A
A
E
F
L
R
-ME---ADW----
E
A
S
Y
L
L
S
L
R
A
A
WQADNNIPN
S
K
E
A
S
M
S
K
A
KAGRMASD
V
T
C
K
T
V
E
L
AGTTGY
S
E
Q
S
L
L
E
K
W
ARDS
K
I
L
D
I
F
E
G
T
Q
Q
I
Q
Q
L
V
V
A
R
R
L
LGLSSSELK
37
PsiBlast_CBE
93.04
31%
-57
- C2 -
1EGE
3
ACADM_HUMAN
D:
[10-388]
L
G
F
S
F
E
F
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
K
T
G
E
Y
P
V
P
L
-
I
R
-------
R
A
W
E
L
G
L
M
N
T
H
I
--------
P
E
N
C
G
G
L
G
L
G
TFD
A
C
L
I
S
E
E
L
A
Y
G
C
--
T
G
V
Q
T
A
I
E
G
N
S
L
G
Q
M
P
I
I
I
A
G
N
D
Q
Q
K
K
K
Y-----
L
------
G
R
MTEEP
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
---
P
D
---
P
K
----
A
P
A
N
K
A
F
TGF
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
----
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
T
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
---
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
-
M
A
---
M
K
V
----
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
R
N
T
Y
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
S
Q
I
Q
R
L
I
V
A
R
-----------
39
PsiBlast_CBE
92.70
31%
-54
- C2 -
1EGE
3
ACADM_HUMAN
B:
[10-388]
L
G
F
S
F
E
F
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
K
T
G
E
Y
P
V
P
L
-
I
R
-------
R
A
W
E
L
G
L
M
N
T
H
I
--------
P
E
N
C
G
G
L
G
L
G
TFD
A
C
L
I
S
E
E
L
A
Y
G
C
--
T
G
V
Q
T
A
I
E
G
N
S
L
G
Q
M
P
I
I
I
A
G
N
D
Q
Q
K
K
K
Y-----
L
------
G
R
MTEEP
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
---
P
D
---
P
K
----
A
P
A
N
K
A
F
TGF
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
----
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
T
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
---
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
-
M
A
---
M
K
V
----
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
R
N
T
Y
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
S
Q
I
Q
R
L
I
V
A
R
-----------
31
PsiBlast_CBE
92.70
31%
-53
- C2 -
4P13
3
ACADM_HUMAN
D:
[1-379]
L
G
F
S
F
E
F
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
K
T
G
E
Y
P
V
P
L
-
I
R
-------
R
A
W
E
L
G
L
M
N
T
H
I
--------
P
E
N
C
G
G
L
G
L
G
TFD
A
C
L
I
S
E
E
L
A
Y
G
C
--
T
G
V
Q
T
A
I
E
G
N
S
L
G
Q
M
P
I
I
I
A
G
N
D
Q
Q
K
K
K
Y-----
L
------
G
R
MTEEP
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
---
P
D
---
P
K
----
A
P
A
N
K
A
F
TGF
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
----
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
T
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
---
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
-
M
A
---
M
E
V
----
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
R
N
T
Y
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
S
Q
I
Q
R
L
I
V
A
R
-----------
42
PsiBlast_CBE
92.57
31%
-54
- C2 -
2A1T
3
ACADM_HUMAN
B:
[35-413]
L
G
F
S
F
E
F
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
K
T
G
E
Y
P
V
P
L
-
I
R
-------
R
A
W
E
L
G
L
M
N
T
H
I
--------
P
E
N
C
G
G
L
G
L
G
T
F
D
A
C
L
I
S
E
E
L
A
Y
G
C
--
T
G
V
Q
T
A
I
E
G
N
S
L
G
Q
M
P
I
I
I
A
G
N
D
Q
Q
K
K
K
Y
-----
L
------
G
R
M
T
E
EP
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
---
P
D
---
P
K
----
A
P
A
N
K
A
F
T
G
F
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
----
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
T
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
---
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
-
M
A
---
M
K
V
----
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
R
N
T
Y
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
S
Q
I
Q
R
L
I
V
A
R
-----------
38
PsiBlast_CBE
92.41
31%
-54
- C2 -
1EGE
3
ACADM_HUMAN
C:
[10-388]
L
G
F
S
F
E
F
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
K
T
G
E
Y
P
V
P
L
-
I
R
-------
R
A
W
E
L
G
L
M
N
T
H
I
--------
P
E
N
C
G
G
L
G
L
G
TFD
A
C
L
I
S
E
E
L
A
Y
G
C
--
T
G
V
Q
T
A
I
E
G
N
S
L
G
Q
M
P
I
I
I
A
G
N
D
Q
Q
K
K
K
Y-----
L
------
G
R
MTEEP
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
---
P
D
---
P
K
----
A
P
A
N
K
A
F
TGF
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
----
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
T
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
---
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
-
M
A
---
M
K
V
----
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
R
N
T
Y
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
S
Q
I
Q
R
L
I
V
A
R
-----------
3
PsiBlast_PDB
92.32
31%
-54
- C2 -
4P13
3
ACADM_HUMAN
A:
[1-379]
L
G
F
S
F
E
F
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
K
T
G
E
Y
P
V
P
L
-
I
R
-------
R
A
W
E
L
G
L
M
N
T
H
I
--------
P
E
N
C
G
G
L
G
L
G
T
F
D
A
C
L
I
S
E
E
L
A
Y
G
C
--
T
G
V
Q
T
A
I
E
G
N
S
L
G
Q
M
P
I
I
I
A
G
N
D
Q
Q
K
K
K
Y-----
L
------
G
R
M
T
E
EP
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
---
P
D
---
P
K
----
A
P
A
N
K
A
F
T
G
F
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
----
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
T
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
---
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
-
M
A
---
M
E
V
----
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
R
N
T
Y
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
S
Q
I
Q
R
L
I
V
A
R
-----------
45
PsiBlast_CBE
92.27
31%
-55
- C2 -
1EGD
3
ACADM_HUMAN
D:
[10-388]
L
G
F
S
F
E
F
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
K
T
G
E
Y
P
V
P
L
-
I
R
-------
R
A
W
E
L
G
L
M
N
T
H
I
--------
P
E
N
C
G
G
L
G
L
G
TFD
A
C
L
I
S
E
E
L
A
Y
G
C
--
T
G
V
Q
T
A
I
E
G
N
S
L
G
Q
M
P
I
I
I
A
G
N
D
Q
Q
K
K
K
Y-----
L
------
G
R
MTEEP
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
---
P
D
---
P
K
----
A
P
A
N
K
A
F
TGF
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
----
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
E
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
---
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
-
M
A
---
M
K
V
----
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
R
N
T
Y
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
G
G
T
S
Q
I
Q
R
L
I
V
A
R
-----------
47
PsiBlast_CBE
92.12
31%
-52
- C2 -
1EGD
3
ACADM_HUMAN
B:
[10-388]
L
G
F
S
F
E
F
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
K
T
G
E
Y
P
V
P
L
-
I
R
-------
R
A
W
E
L
G
L
M
N
T
H
I
--------
P
E
N
C
G
G
L
G
L
G
TFD
A
C
L
I
S
E
E
L
A
Y
G
C
--
T
G
V
Q
T
A
I
E
G
N
S
L
G
Q
M
P
I
I
I
A
G
N
D
Q
Q
K
K
K
Y-----
L
------
G
R
MTEEP
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
---
P
D
---
P
K
----
A
P
A
N
K
A
F
TGF
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
----
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
E
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
---
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
-
M
A
---
M
K
V
----
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
R
N
T
Y
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
G
G
T
S
Q
I
Q
R
L
I
V
A
R
-----------
36
PsiBlast_CBE
91.76
31%
-54
- C2 -
1T9G
3
ACADM_HUMAN
B:
[10-388]
L
G
F
S
F
E
F
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
K
T
G
E
Y
P
V
P
L
-
I
R
-------
R
A
W
E
L
G
L
M
N
T
H
I
--------
P
E
N
C
G
G
L
G
L
G
T
F
D
A
C
L
I
S
E
E
L
A
Y
G
C
--
T
G
V
Q
T
A
I
E
G
N
S
L
G
Q
M
P
I
I
I
A
G
N
D
Q
Q
K
K
K
Y
-----
L
------
G
R
M
T
E
EP
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
---
P
D
---
P
K
----
A
P
A
N
K
A
F
T
G
F
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
----
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
T
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
---
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
-
M
A
---
M
K
V
----
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
R
N
T
Y
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
S
Q
I
Q
R
L
I
V
A
R
-----------
49
PsiBlast_CBE
91.66
31%
-55
- C2 -
1EGC
5
ACADM_HUMAN
C:
[10-388]
L
G
F
S
F
E
F
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
K
T
G
E
Y
P
V
P
L
-
I
R
-------
R
A
W
E
L
G
L
M
N
T
H
I
--------
P
E
N
C
G
G
L
G
L
G
TFD
A
C
L
I
S
E
E
L
A
Y
G
C
--
T
G
V
Q
T
A
I
E
G
N
S
L
G
Q
M
P
I
I
I
A
G
N
D
Q
Q
K
K
K
Y-----
L
------
G
R
MTEEP
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
---
P
D
---
P
K
----
A
P
A
N
K
A
F
TGF
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
----
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
E
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
---
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
-
M
A
---
M
K
V
----
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
R
N
T
Y
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
G
G
T
S
Q
I
Q
R
L
I
V
A
R
-----------
33
PsiBlast_CBE
91.53
31%
-53
- C2 -
4P13
3
ACADM_HUMAN
B:
[1-379]
L
G
F
S
F
E
F
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
K
T
G
E
Y
P
V
P
L
-
I
R
-------
R
A
W
E
L
G
L
M
N
T
H
I
--------
P
E
N
C
G
G
L
G
L
G
TFD
A
C
L
I
S
E
E
L
A
Y
G
C
--
T
G
V
Q
T
A
I
E
G
N
S
L
G
Q
M
P
I
I
I
A
G
N
D
Q
Q
K
K
K
Y-----
L
------
G
R
MTEEP
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
---
P
D
---
P
K
----
A
P
A
N
K
A
F
TGF
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
----
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
T
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
---
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
-
M
A
---
M
E
V
----
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
R
N
T
Y
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
S
Q
I
Q
R
L
I
V
A
R
-----------
32
PsiBlast_CBE
91.32
31%
-53
- C2 -
4P13
3
ACADM_HUMAN
C:
[1-379]
L
G
F
S
F
E
F
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
K
T
G
E
Y
P
V
P
L
-
I
R
-------
R
A
W
E
L
G
L
M
N
T
H
I
--------
P
E
N
C
G
G
L
G
L
G
TFD
A
C
L
I
S
E
E
L
A
Y
G
C
--
T
G
V
Q
T
A
I
E
G
N
S
L
G
Q
M
P
I
I
I
A
G
N
D
Q
Q
K
K
K
Y-----
L
------
G
R
MTEEP
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
---
P
D
---
P
K
----
A
P
A
N
K
A
F
TGF
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
----
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
T
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
---
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
-
M
A
---
M
E
V
----
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
R
N
T
Y
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
S
Q
I
Q
R
L
I
V
A
R
-----------
10
PsiBlast_PDB
91.22
31%
-55
- C2 -
1EGD
3
ACADM_HUMAN
A:
[10-388]
L
G
F
S
F
E
F
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
K
T
G
E
Y
P
V
P
L
-
I
R
-------
R
A
W
E
L
G
L
M
N
T
H
I
--------
P
E
N
C
G
G
L
G
L
G
T
F
D
A
C
L
I
S
E
E
L
A
Y
G
C
--
T
G
V
Q
T
A
I
E
G
N
S
L
G
Q
M
P
I
I
I
A
G
N
D
Q
Q
K
K
K
Y
-----
L
------
G
R
M
T
E
EP
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
---
P
D
---
P
K
----
A
P
A
N
K
A
F
T
G
F
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
----
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
E
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
---
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
-
M
A
---
M
K
V
----
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
R
N
T
Y
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
G
G
T
S
Q
I
Q
R
L
I
V
A
R
-----------
99
HHSearch
91.18
31%
-56
- C2 -
4P13
3
ACADM_HUMAN
A:
[2-386]
-
G
F
S
F
E
F
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
K
T
G
-
E
Y
P
V
P
L
I
R
R
A
W
E
L
G
--
L
M
N
---
T
H
--------
I
P
E
N
C
G
G
L
G
L
G
T
F
D
---
A
C
L
I
S
E
E
L
A
Y
G
C
--
T
G
V
Q
T
A
I
E
G
N
S
L
G
Q
M
P
I
I
I
A
G
N
D
Q
Q
K
K
K
------
Y
L
G
R
M
T
E
E
P
-----
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
---
P
D
PKA
P
A
----
N
K
A
F
T
G
F
---
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
I
G
D
----
G
A
G
F
K
V
A
M
G
A
F
D
K
T
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
---
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
-
M
A
---
M
E
V
----
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
R
N
T
Y
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
S
Q
I
Q
R
L
I
V
A
R
E
H
I
D
K
Y
K
----
46
PsiBlast_CBE
91.18
31%
-55
- C2 -
1EGD
3
ACADM_HUMAN
C:
[10-388]
L
G
F
S
F
E
F
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
K
T
G
E
Y
P
V
P
L
-
I
R
-------
R
A
W
E
L
G
L
M
N
T
H
I
--------
P
E
N
C
G
G
L
G
L
G
TFD
A
C
L
I
S
E
E
L
A
Y
G
C
--
T
G
V
Q
T
A
I
E
G
N
S
L
G
Q
M
P
I
I
I
A
G
N
D
Q
Q
K
K
K
Y-----
L
------
G
R
MTEEP
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
---
P
D
---
P
K
----
A
P
A
N
K
A
F
TGF
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
----
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
E
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
---
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
-
M
A
---
M
K
V
----
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
R
N
T
Y
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
G
G
T
S
Q
I
Q
R
L
I
V
A
R
-----------
40
PsiBlast_CBE
91.15
31%
-52
- C2 -
2A1T
4
ACADM_HUMAN
D:
[35-413]
L
G
F
S
F
E
F
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
K
T
G
E
Y
P
V
P
L
-
I
R
-------
R
A
W
E
L
G
L
M
N
T
H
I
--------
P
E
N
C
G
G
L
G
L
G
TFD
A
C
L
I
S
E
E
L
A
Y
G
C
--
T
G
V
Q
T
A
I
E
G
N
S
L
G
Q
M
P
I
I
I
A
G
N
D
Q
Q
K
K
K
Y-----
L
------
G
R
MTEEP
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
---
P
D
---
P
K
----
A
P
A
N
K
A
F
TGF
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
----
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
T
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
---
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
-
M
A
---
M
K
V
----
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
R
N
T
Y
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
S
Q
I
Q
R
L
I
V
A
R
-----------
35
PsiBlast_CBE
91.12
31%
-55
- C2 -
1T9G
3
ACADM_HUMAN
C:
[10-388]
L
G
F
S
F
E
F
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
K
T
G
E
Y
P
V
P
L
-
I
R
-------
R
A
W
E
L
G
L
M
N
T
H
I
--------
P
E
N
C
G
G
L
G
L
G
TFD
A
C
L
I
S
E
E
L
A
Y
G
C
--
T
G
V
Q
T
A
I
E
G
N
S
L
G
Q
M
P
I
I
I
A
G
N
D
Q
Q
K
K
K
Y-----
L
------
G
R
MTEEP
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
---
P
D
---
P
K
----
A
P
A
N
K
A
F
TGF
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
----
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
T
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
---
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
-
M
A
---
M
K
V
----
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
R
N
T
Y
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
S
Q
I
Q
R
L
I
V
A
R
-----------
4
PsiBlast_PDB
91.04
31%
-57
- C2 -
1EGE
3
ACADM_HUMAN
A:
[10-388]
L
G
F
S
F
E
F
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
K
T
G
E
Y
P
V
P
L
-
I
R
-------
R
A
W
E
L
G
L
M
N
T
H
I
--------
P
E
N
C
G
G
L
G
L
G
T
F
D
A
C
L
I
S
E
E
L
A
Y
G
C
--
T
G
V
Q
T
A
I
E
G
N
S
L
G
Q
M
P
I
I
I
A
G
N
D
Q
Q
K
K
K
Y-----
L
------
G
R
M
T
E
E
P
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
---
P
D
---
P
K
----
A
P
A
N
K
A
F
T
G
F
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
----
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
T
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
---
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
-
M
A
---
M
K
V
----
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
R
N
T
Y
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
S
Q
I
Q
R
L
I
V
A
R
-----------
48
PsiBlast_CBE
90.93
31%
-56
- C2 -
1EGC
5
ACADM_HUMAN
D:
[10-388]
L
G
F
S
F
E
F
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
K
T
G
E
Y
P
V
P
L
-
I
R
-------
R
A
W
E
L
G
L
M
N
T
H
I
--------
P
E
N
C
G
G
L
G
L
G
TFD
A
C
L
I
S
E
E
L
A
Y
G
C
--
T
G
V
Q
T
A
I
E
G
N
S
L
G
Q
M
P
I
I
I
A
G
N
D
Q
Q
K
K
K
Y-----
L
------
G
R
MTEEP
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
---
P
D
---
P
K
----
A
P
A
N
K
A
F
TGF
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
----
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
E
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
---
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
-
M
A
---
M
K
V
----
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
R
N
T
Y
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
G
G
T
S
Q
I
Q
R
L
I
V
A
R
-----------
6
PsiBlast_PDB
90.88
31%
-51
- C2 -
2A1T
3
ACADM_HUMAN
A:
[35-413]
L
G
F
S
F
E
F
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
-
K
T
G
E
Y
P
V
P
L
-
I
R
-------
R
A
W
E
L
G
L
M
N
T
H
I
--------
P
E
N
C
G
G
L
G
L
G
T
F
D
A
C
L
I
S
E
E
L
A
Y
G
C
--
T
G
V
Q
T
A
I
E
G
N
S
L
G
Q
M
P
I
I
I
A
G
N
D
Q
Q
K
K
K
Y-----
L
------
G
R
M
T
E
EP
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
---
P
D
---
P
K
----
A
P
A
N
K
A
F
T
G
F
I
V
E
A
D
T
P
G
I
Q
I
G
R
K
E
L
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
K
V
P
K
E
N
V
L
----
I
G
D
G
A
G
F
K
V
A
M
G
A
F
D
K
T
R
P
V
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
---
A
L
E
R
K
T
F
G
K
L
L
V
E
H
Q
A
I
S
F
M
L
A
E
-
M
A
---
M
K
V
----
E
L
A
R
M
S
Y
Q
R
A
A
W
E
V
D
S
G
R
R
N
T
Y
Y
A
S
I
A
K
A
F
A
G
D
I
A
N
Q
L
A
T
D
A
V
Q
I
L
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
S
Q
I
Q
R
L
I
V
A
R
-----------
79
Fugue
88.42
30%
-52
- C2 -
3MDD
2
ACADM_PIG
A:
[1-385]
-
G
F
S
F
E
L
T
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
R
T
G
E
-
Y
P
--
V
-
P
L
L
K
R
A
W
E
L
-----
G
L
M
N
T
H
I
P
E
S
F
G
G
L
G
---
L
G
I
I
D
S
C
---
L
I
T
E
E
L
A
Y
G
C
T
G
--
V
Q
T
A
I
E
A
N
T
--
L
G
Q
V
P
L
I
I
G
G
N
Y
Q
Q
Q
K
K
------
Y
L
G
R
M
T
E
E
P
-----
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
G
-D
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
PDP
K
A
---
P
A
----
S
K
A
F
T
G
F
---
I
V
E
A
D
T
P
G
V
Q
I
G
R
K
E
I
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
G
E
----
G
A
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
---
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
-
M
A
---
M
K
V
----
E
L
A
R
L
S
Y
Q
R
A
A
W
E
I
D
S
G
R
R
N
T
Y
Y
A
S
I
A
K
A
Y
A
A
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
A
R
E
H
I
G
R
Y
K
----
8
PsiBlast_PDB
79.84
34%
-59
- C2 -
4N5F
10
?
A:
[83-385]
---------------------------------------------------------------------------------------------
E
V
A
A
G
D
A
A
C
A
T
M
M
S
V
-
H
N
S
V
G
C
G
P
I
L
G
F
G
T
P
A
Q
K
D
R
W
L
A
D
M
A
A
------
G
R
-----
V
I
G
A
F
C
L
T
E
P
H
A
G
S
E
A
N
N
L
R
T
R
A
E
L
R
D
G
-
Q
W
V
L
N
G
A
K
Q
F
V
T
N
G
Q
R
A
G
V
A
I
V
F
A
M
T
D
---
P
E
---
A
G
----
K
R
G
I
S
A
F
---
L
V
P
T
D
T
P
G
F
I
V
G
K
P
E
K
K
M
G
I
R
A
S
D
T
C
P
I
T
F
E
N
C
A
I
P
E
D
N
L
L
G
N
R
----
G
E
G
L
K
I
A
L
S
N
L
E
G
G
R
I
G
I
A
A
Q
A
L
G
I
A
R
A
A
F
D
K
A
R
R
Y
---
A
G
E
R
V
Q
F
G
K
P
I
A
E
H
Q
A
I
Q
Q
K
L
A
D
-
M
A
---
V
Q
I
----
N
A
A
R
L
L
V
H
H
A
A
K
L
R
T
A
G
L
P
C
L
S
E
A
S
Q
A
K
L
F
A
S
E
M
A
E
R
V
C
S
D
A
I
Q
I
H
G
G
Y
G
Y
L
V
D
Y
E
V
E
R
H
Y
R
D
A
R
I
T
Q
I
Y
E
G
T
S
E
V
Q
R
M
V
I
A
R
Q
L
---------
53
PsiBlast_CBE
76.46
34%
-51
- C2 -
3MDD
2
ACADM_PIG
B:
[74-382]
-------------------------------------------------------------------------------------------
T
E
E
L
A
Y
G
C
--
T
G
V
Q
T
A
I
E
A
N
T
L
G
Q
V
P
L
I
I
G
G
N
Y
Q
Q
Q
K
K
Y-----
L
------
G
R
MTEEP
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
---
P
D
---
P
K
----
A
P
A
S
K
A
F
TGF
I
V
E
A
D
T
P
G
V
Q
I
G
R
K
E
I
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
G
E
----
G
A
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
---
A
L
E
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
-
M
A
---
M
K
V
----
E
L
A
R
L
S
Y
Q
R
A
A
W
E
I
D
S
G
R
R
N
T
Y
Y
A
S
I
A
K
A
Y
A
A
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
A
R
E
H
I
G
-------
52
PsiBlast_CBE
76.08
34%
-52
- C2 -
3MDE
4
ACADM_PIG
B:
[74-382]
-------------------------------------------------------------------------------------------
T
E
E
L
A
Y
G
C
--
T
G
V
Q
T
A
I
E
A
N
T
L
G
Q
V
P
L
I
I
G
G
N
Y
Q
Q
Q
K
K
Y-----
L
------
G
R
MTEEP
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
---
P
D
---
P
K
----
A
P
A
S
K
A
F
TGF
I
V
E
A
D
T
P
G
V
Q
I
G
R
K
E
I
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
G
E
----
G
A
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
---
A
L
E
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
-
M
A
---
M
K
V
----
E
L
A
R
L
S
Y
Q
R
A
A
W
E
I
D
S
G
R
R
N
T
Y
Y
A
S
I
A
K
A
Y
A
A
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
A
R
E
H
I
G
-------
44
PsiBlast_CBE
75.82
34%
-59
- C2 -
4N5F
10
?
B:
[83-385]
---------------------------------------------------------------------------------------------
E
V
A
A
G
D
A
A
C
A
T
M
M
S
V
-
H
N
S
V
G
C
G
P
I
L
G
F
G
T
P
A
Q
K
D
R
W
L
A
D
M
A
A
------
G
R
-----
V
I
G
A
F
C
L
T
E
P
H
-------
L
R
T
R
A
E
L
R
D
---
W
V
L
N
G
A
K
Q
F
V
T
N
G
Q
R
A
G
V
A
I
V
F
A
M
T
D
---
P
E
---
A
G
----
K
R
G
I
S
A
F
---
L
V
P
T
D
T
P
G
F
I
V
G
K
P
E
K
K
M
G
I
R
A
S
D
T
C
P
I
T
F
E
N
C
A
I
P
E
D
N
L
L
G
N
R
----
G
E
G
L
K
I
A
L
S
N
L
E
G
G
R
I
G
I
A
A
Q
A
L
G
I
A
R
A
A
F
D
K
A
R
R
Y
---
A
G
E
R
V
Q
F
G
K
P
I
A
E
H
Q
A
I
Q
Q
K
L
A
D
-
M
A
---
V
Q
I
----
N
A
A
R
L
L
V
H
H
A
A
K
L
R
T
A
G
L
P
C
L
S
E
A
S
Q
A
K
L
F
A
S
E
M
A
E
R
V
C
S
D
A
I
Q
I
H
G
G
Y
G
Y
L
V
D
Y
E
V
E
R
H
Y
R
D
A
R
I
T
Q
I
Y
E
G
T
S
E
V
Q
R
M
V
I
A
R
Q
L
---------
14
PsiBlast_PDB
75.68
34%
-54
- C2 -
3MDE
3
ACADM_PIG
A:
[74-382]
-------------------------------------------------------------------------------------------
T
E
E
L
A
Y
G
C
--
T
G
V
Q
T
A
I
E
A
N
T
L
G
Q
V
P
L
I
I
G
G
N
Y
Q
Q
Q
K
K
Y
-----
L
------
G
R
M
T
E
EP
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
---
P
D
---
P
K
----
A
P
A
S
K
A
F
T
G
F
I
V
E
A
D
T
P
G
V
Q
I
G
R
K
E
I
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
G
E
----
G
A
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
---
A
L
E
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
-
M
A
---
M
K
V
----
E
L
A
R
L
S
Y
Q
R
A
A
W
E
I
D
S
G
R
R
N
T
Y
Y
A
S
I
A
K
A
Y
A
A
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
A
R
E
H
I
G
-------
13
PsiBlast_PDB
74.78
34%
-53
- C2 -
3MDD
2
ACADM_PIG
A:
[74-382]
-------------------------------------------------------------------------------------------
T
E
E
L
A
Y
G
C
--
T
G
V
Q
T
A
I
E
A
N
T
L
G
Q
V
P
L
I
I
G
G
N
Y
Q
Q
Q
K
K
Y-----
L
------
G
R
M
T
E
EP
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
E
K
K
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
---
P
D
---
P
K
----
A
P
A
S
K
A
F
T
G
F
I
V
E
A
D
T
P
G
V
Q
I
G
R
K
E
I
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
G
E
----
G
A
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
---
A
L
E
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
-
M
A
---
M
K
V
----
E
L
A
R
L
S
Y
Q
R
A
A
W
E
I
D
S
G
R
R
N
T
Y
Y
A
S
I
A
K
A
Y
A
A
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
A
R
E
H
I
G
-------
51
PsiBlast_CBE
72.77
36%
-60
- C2 -
4L1F
5
?
B:
[98-378]
---------------------------------------------------------------------------------------------------------------------
I
Y
M
F
G
T
E
E
Q
K
Q
K
------
Y
LAPIAE
G
T
-----
H
V
G
A
F
G
L
T
E
P
S
A
G
T
D
A
S
A
Q
Q
T
T
A
V
L
K
G
D
-
K
Y
I
L
N
G
S
K
I
F
I
T
N
G
K
E
A
D
T
Y
V
V
F
A
M
T
D
---
K
S
---
Q
G
----
V
H
G
I
S
A
F
---
I
L
E
K
G
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
C
E
V
P
K
E
N
L
L
G
K
E
----
G
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
--------
A
A
A
V
K
Y
S
K
E
R
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
---
A
D
M
ATKI
E
A
A
R
Y
L
V
Y
H
A
A
M
L
K
N
E
G
K
P
Y
S
E
A
A
A
M
A
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
R
A
L
L
--------
12
PsiBlast_PDB
72.12
36%
-60
- C2 -
4L1F
6
?
A:
[98-378]
---------------------------------------------------------------------------------------------------------------------
I
Y
M
F
G
T
E
E
Q
K
Q
K
------
Y
L
A
P
I
A
E
G
T
-----
H
V
G
A
F
G
L
T
E
P
S
A
G
T
D
A
S
A
Q
Q
T
T
A
V
L
K
G
D
-
K
Y
I
L
N
G
S
K
I
F
I
T
N
G
K
E
A
D
T
Y
V
V
F
A
M
T
D
---
K
S
---
Q
G
----
V
H
G
I
S
A
F
---
I
L
E
K
G
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
C
E
V
P
K
E
N
L
L
G
K
E
----
G
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
--------
A
A
A
V
K
Y
S
K
E
R
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
---
A
D
M
A
T
K
I
E
A
A
R
Y
L
V
Y
H
A
A
M
L
K
N
E
G
K
P
Y
S
E
A
A
A
M
A
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
R
A
L
L
--------
69
PsiBlast_CBE
70.21
34%
-54
- C2 -
2D29
2
?
B:
[119-384]
----------------------------------------------------------------------------------------------------------------------------------------------
G
E
-----
A
L
G
A
W
G
L
T
E
P
G
S
G
S
D
A
A
A
L
K
T
K
A
E
K
V
E
G
-
G
W
R
L
N
G
T
K
Q
F
I
T
Q
G
S
V
A
G
V
Y
V
V
M
A
R
T
D
---
P
P
---
P
S
PERK
H
Q
G
I
S
A
F
---
A
F
F
R
P
E
R
G
L
K
V
G
R
K
E
E
K
L
G
L
T
A
S
D
T
A
Q
L
I
L
E
D
L
F
V
P
E
E
A
L
L
G
----
E
R
G
K
G
F
Y
D
V
L
R
V
L
D
G
G
R
I
G
I
A
A
M
A
V
G
L
G
Q
A
A
L
D
Y
A
L
A
Y
A
K
G
---
R
E
A
F
G
R
P
I
A
E
F
E
G
V
S
F
K
L
A
E
-
A
A
---
T
E
L
----
E
A
A
R
L
L
Y
L
K
A
A
E
L
K
D
A
G
R
P
F
T
L
E
A
A
Q
A
K
L
F
A
S
E
A
A
V
K
A
C
D
E
A
I
Q
I
L
G
G
Y
G
Y
V
K
D
Y
P
V
E
R
Y
W
R
D
A
R
L
T
R
I
G
E
G
T
S
E
I
L
K
L
V
I
A
R
R
L
L
--------
70
PsiBlast_CBE
69.26
34%
-52
- C2 -
2D29
2
?
A:
[119-384]
----------------------------------------------------------------------------------------------------------------------------------------------
G
E
-----
A
L
G
A
W
G
L
T
E
P
G
S
G
S
D
A
A
A
L
K
T
K
A
E
K
V
E
G
-
G
W
R
L
N
G
T
K
Q
F
I
T
Q
G
S
V
A
G
V
Y
V
V
M
A
R
T
D
---
P
P
---
P
S
PERK
H
Q
G
I
S
A
F
---
A
F
F
R
P
E
R
G
L
K
V
G
R
K
E
E
K
L
G
L
T
A
S
D
T
A
Q
L
I
L
E
D
L
F
V
P
E
E
A
L
L
G
----
E
R
G
K
G
F
Y
D
V
L
R
V
L
D
G
G
R
I
G
I
A
A
M
A
V
G
L
G
Q
A
A
L
D
Y
A
L
A
Y
A
K
G
---
R
E
A
F
G
R
P
I
A
E
F
E
G
V
S
F
K
L
A
E
-
A
A
---
T
E
L
----
E
A
A
R
L
L
Y
L
K
A
A
E
L
K
D
A
G
R
P
F
T
L
E
A
A
Q
A
K
L
F
A
S
E
A
A
V
K
A
C
D
E
A
I
Q
I
L
G
G
Y
G
Y
V
K
D
Y
P
V
E
R
Y
W
R
D
A
R
L
T
R
I
G
E
G
T
S
E
I
L
K
L
V
I
A
R
R
L
L
--------
62
PsiBlast_CBE
68.67
34%
-55
- C2 -
1BUC
3
ACDS_MEGEL
B:
[120-382]
----------------------------------------------------------------------------------------------------------------------------------------------
G
T
-----
K
L
G
A
F
G
L
T
E
P
N
A
G
T
D
A
S
G
Q
Q
T
I
A
T
K
N
D
D
G
T
Y
T
L
N
G
S
K
I
F
I
T
N
G
G
A
A
D
I
Y
I
V
F
A
M
T
D
---
K
S
---
K
G
----
N
H
G
I
T
A
F
---
I
L
E
D
G
T
P
G
F
T
Y
G
K
K
E
D
K
M
G
I
H
T
S
Q
T
M
E
L
V
F
Q
D
V
K
V
P
A
E
N
M
L
G
----
E
E
G
K
G
F
K
I
A
M
M
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
A
D
---
A
V
E
Y
S
K
Q
R
V
Q
F
G
K
P
L
C
K
F
Q
S
I
S
F
K
L
A
D
-
M
K
---
M
Q
I
----
E
A
A
R
N
L
V
Y
K
A
A
C
K
K
Q
E
G
K
P
F
T
V
D
A
A
I
A
K
R
V
A
S
D
V
A
M
R
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
E
V
Q
L
M
V
T
G
G
A
L
L
--------
43
PsiBlast_CBE
67.25
36%
-56
- C2 -
1JQI
4
ACADS_RAT
B:
[127-383]
--------------------------------------------------------------------------------------------------------------------------------------------------------
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
E
E
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
S
W
E
A
S
A
T
V
V
F
A
S
T
D
---
R
S
---
R
Q
----
N
K
G
I
S
A
F
---
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
A
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
E
N
L
L
G
E
P
----
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
A
S
L
D
----------
C
A
V
K
Y
A
E
N
R
H
A
F
G
A
P
L
T
K
L
Q
N
-
I
Q
FKL
A
D
M
ALAL
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
P
F
T
K
E
S
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
Y
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
L
--------
7
PsiBlast_PDB
67.14
36%
-56
- C2 -
1JQI
4
ACADS_RAT
A:
[127-383]
--------------------------------------------------------------------------------------------------------------------------------------------------------
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
R
E
E
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
S
W
E
A
S
A
T
V
V
F
A
S
T
D
---
R
S
---
R
Q
----
N
K
G
I
S
A
F
---
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
A
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
E
N
L
L
G
E
P
----
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
A
S
L
D
----------
C
A
V
K
Y
A
E
N
R
H
A
F
G
A
P
L
T
K
L
Q
N
-
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
P
F
T
K
E
S
A
M
A
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
Y
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
L
--------
20
PsiBlast_PDB
66.88
34%
-49
- C2 -
1BUC
3
ACDS_MEGEL
A:
[120-382]
----------------------------------------------------------------------------------------------------------------------------------------------
G
T
-----
K
L
G
A
F
G
L
T
E
P
N
A
G
T
D
A
S
G
Q
Q
T
I
A
T
K
N
D
D
G
T
Y
T
L
N
G
S
K
I
F
I
T
N
G
G
A
A
D
I
Y
I
V
F
A
M
T
D
---
K
S
---
K
G
----
N
H
G
I
T
A
F
---
I
L
E
D
G
T
P
G
F
T
Y
G
K
K
E
D
K
M
G
I
H
T
S
Q
T
M
E
L
V
F
Q
D
V
K
V
P
A
E
N
M
L
G
----
E
E
G
K
G
F
K
I
A
M
M
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
A
D
---
A
V
E
Y
S
K
Q
R
V
Q
F
G
K
P
L
C
K
F
Q
S
I
S
F
K
L
A
D
-
M
K
---
M
Q
I
----
E
A
A
R
N
L
V
Y
K
A
A
C
K
K
Q
E
G
K
P
F
T
V
D
A
A
I
A
K
R
V
A
S
D
V
A
M
R
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
E
V
Q
L
M
V
T
G
G
A
L
L
--------
66
PsiBlast_CBE
65.60
33%
-51
- C2 -
2DVL
2
?
A:
[120-370]
--------------------------------------------------------------------------------------------------------------------------------------------------------
A
F
C
L
T
E
P
Q
A
G
S
D
A
K
S
L
R
A
E
A
R
R
V
K
G
-
G
F
V
L
N
G
V
K
S
W
I
T
S
A
G
H
A
H
L
Y
V
V
M
A
R
T
E
---
K
G
------------
I
S
A
F
---
L
V
E
K
G
T
P
G
L
S
F
G
R
P
E
E
K
M
G
L
H
A
A
H
T
A
E
V
R
L
E
E
V
F
V
P
E
E
N
L
L
G
----
E
E
G
R
G
L
A
Y
A
L
A
G
L
D
S
G
R
V
G
V
A
A
Q
A
V
G
I
A
R
G
A
F
E
I
A
K
A
Y
---
A
E
E
R
E
Q
F
G
K
K
L
K
E
H
Q
A
I
A
F
K
I
A
D
-
M
H
---
V
K
I
----
A
A
A
R
A
L
V
L
E
A
A
R
K
K
D
R
G
E
R
F
T
L
E
A
S
A
A
K
L
F
A
S
A
A
A
V
E
V
T
R
E
A
V
Q
V
L
G
G
Y
G
Y
H
R
D
Y
R
V
E
R
Y
Y
R
D
A
K
V
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
R
E
L
---------