@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3197: (2016-05-17 )
MDDGSVSDIKRGRAARNAKLASIPVGFAGRAALGLGKRLTGKSKDEVTAELMEKAANQLFTVLGELKGGAMKVGQALSVMEAAIPDEFGEPYREALTKLQKDAPPLPASKVHRVLDGQLGTKWRERFSSFNDTPVASASIGQVHKAIWSDGREVAVKIQYPGADEALRADLKTMQRMVGVLKQLSPGADVQGVVDELVERTEMELDYRLEAANQRAFAKAYHDHPRFQVPHVVASAPKVVIQEWIEGVPMAEIIRHGTTEQRDLIGTLLAELTFDAPRRLGLMHGDAHPGNFMLLPDGRMGIIDFGAVAPMPGGFPIELGMTIRLAREKNYDLLLPTMEKAGLIQRGRQVSVREIDEMLRQYVEPIQVEVFHYTRKWLQKMTVSQIDRSVAQIRTARQMDLPAKLAIPMRVIASVGAILCQLDAHVPIKALSEELIPGFAEPDAIVV
Atome Classification :
(20 SA)
------.........10----------------........20........30........---40-........50........60........70........80..-..-....90.-.......100--........110..--.....120.......130........140.......-150----------.........160......----.170.......180..--...-------..190-----...----....200.......-210.......220.......230.-------.--.....240........250....----.-----------.----.---260........270..--.....280...-....290...---.--.-..300.......310.....------..320.......330.....-----------..340....-----------...350-........360--.........-370.......380....---...390.......400.....----------..410.......420.......430.......440.....---------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------MDDG
S
V
S
D
I
K
R----------------GRAARNAKLASIPVGFA
G
R
A
A
LGLGKRL---TG-K
S
K
D
E
V
T
A
E
L
M
E
K
A
A
N
Q
L
F
T
V
L
G
E
LKG
G
A
M
K
V
G
Q
A
L
S
V
M
E
A
A-IP-DEF
G
E
P
Y
-
R
E
A
L
T
K
L
QK---DAPPL
P
A
S
K
V
H
R
V
--
L
DGQL
G
T
K
W
R
E
R
FSSFN-DTPVAS
A
S
I
G
Q
V
H
K
A
I
WS-D------------G
R
E
V
A
V
K
I
QYPGA
D
E
A
L
R
----
A
D
L
K
T
M
Q
R
M
V
G
V
L
K
QL--SPG-------A
D
V
Q
G
-----
V
V
D
----
E
L
V
E
R
T
EM
E
L
D
Y
R
L
-EAAN
Q
R
A
F
A
K
A
YHDHPRFQV
P
H
V
V-------A--SA
P
K
V
V
-
I
Q
E
W
IEGV
P
M
A
E
I
I
RH----G-----------T----
T
---
E
Q
-
R
D
L
I
G
T
L
L
A
E
L
TF--DA
P
R
RLGLMHG-DAHPG
N
F
M
L
L---P--D-G
R
M
G
I
I
D
FGAVAPMPG
G
F
P
I
------EL
G
M
T
I
R
L
AREKNY
D
L
LL
P
T
-----------
M
E
K
A
G
L
I
QR-----------GRQV
S
--
V
R
E
I
D
E
M
L
R
----
Q
Y
VEP
I
Q
V
E
-
V
F
H
Y
T
R
K
W
L
Q
K
M
T
V
S
Q
I
---
D
R
S
V
A
Q
I
R
T
A
RQMDLP
A
K
L
A
I
----------
P
M
R
V
I
A
S
V
G
A
I
L
C
QLDAHV
P
I
K
A
L
S
E
E
LIPGFAEPDAIVV---------
114
HHSearch
70.93
25%
1
- C3 -
4PED
2
ADCK3_HUMAN
A:
[4-388]
-------------------------------------------------------------------------------
A
N
A
E
R
I
V
R
T
L
C
K
V
R
G
A
A
L
K
L
G
Q
M
L
S
I
Q
D
D
A
F
I
N
-
P
----
H
L
-
A
K
I
F
E
R
V
R
Q
---
S
A
D
F
M
P
L
K
Q
M
M
K
T
--
L
N
N
D
L
G
P
N
W
R
D
K
L
E
Y
F
E
-
E
R
P
F
A
A
A
S
I
G
Q
V
H
L
A
R
M
K
-
G
------------
G
R
E
V
A
M
K
I
Q
Y
P
G
V
A
Q
S
I
N
----
S
D
V
N
N
L
M
A
V
L
N
M
S
N
M
L
--
P
E
G
-------
L
F
P
E
H
-----
L
I
D
----
V
L
R
R
E
L
A
L
E
C
D
Y
Q
R
-
E
A
A
C
A
R
K
F
R
D
L
L
K
G
H
P
F
F
Y
V
P
E
I
V
-------
D
EL
C
S
P
H
V
L
-
T
T
E
L
V
S
G
F
P
L
D
Q
A
E
G
L
----
S
----------------
Q
---
E
I
-
R
N
E
I
C
Y
N
I
L
V
L
C
L
--
R
E
L
F
E
F
H
F
M
Q
T
-
D
P
N
W
S
N
F
F
Y
D
---
P
--
Q
Q
H
K
V
A
L
L
D
F
G
A
T
R
E
Y
D
R
S
F
T
D
------
L
Y
I
Q
I
I
R
A
A
A
D
R
D
R
E
T
V
R
A
K
-----------
S
I
E
M
K
F
L
T
G
-----------
Y
-
E
V
K
V
M
E
D
A
H
L
D
A
I
L
----
I
L
G
E
A
F
A
S
D
E
P
F
D
F
G
T
Q
S
T
T
E
K
--------
I
H
N
L
I
P
V
M
L
R
H
R
L
V
P
P
P
E
E
T
Y
S
---------
L
H
R
K
M
G
G
S
F
L
I
C
S
K
L
K
A
R
F
P
C
K
A
M
F
E
E
A
Y
S
N
Y
C
K
---------------
109
Fugue
66.08
15%
-38
- C2 -
4WZI
5
PDE4B_HUMAN
A:
[85-576]
------
V
T
P
F
A
Q
V
L
A
S
L
----------------
R
S
V
R
N
N
F
T
I
Q
K
L
A
M
E
T
L
E
E
L
D
W
A
L
D
Q
L
E
T
I
Q
T
Y
-
R
S
V
S
E
M
A
S
N
K
F
K
R
M
L
N
R
E
L
T
H
L
S
E
M
S
R
C
G
N
Q
V
S
E
Y
I
S
N
T
F
---
L
D
-
K
E
N
E
D
H
L
-
A
K
E
L
E
D
L
N
K
WGL
N
I
F
N
V
A
G
Y
S
H
N
R
P
--
L
T
A
I
M
Y
A
I
F
Q
E
R
-
D
L
L
K
-
T
F
R
I
S
S
D
T
F
I
T
Y
M
M
T
L
E
D
-
H
YHSDVAYHN
S
L
H
A
A
D
V
A
Q
S
T
H
V
L
L
S
T
P
A
L
D
----
A
V
F
T
D
L
E
I
L
A
A
I
F
A
A
A
--
I
H
D
-------
V
D
H
P
G
-----
V
S
N
----
Q
F
L
I
N
T
N
S
-------------
E
L
A
L
M
Y
N
D
-
E
S
V
L
E
N
H
H
L
-------
A
--
V
G
F
K
L
L
-
Q
E
E
H
------
A
D
I
F
M
N
----
L
-----------
T
----
K
---
K
Q
-
R
Q
T
L
R
K
M
V
I
D
M
V
L
A
T
D
M
S
K
H
M
S
L
L
A
D
L
K
T
M
V
E
T
K
K
V
T
---
S
--
S
-
G
V
L
L
L
D
N
----------------------------
Y
T
D
R
I
Q
V
L
R
N
M
-----------
V
H
A
A
D
L
S
N
P
-----------
T
K
S
--------
L
E
L
Y
R
----
Q
W
T
D
R
I
M
E
E
-
F
F
Q
Q
G
D
K
E
R
E
R
G
--
M
E
I
---
S
P
M
A
D
K
H
T
A
C
V
E
K
S
Q
V
G
F
I
D
Y
----------
I
V
H
P
L
W
E
T
W
A
D
L
V
Q
P
D
A
----
Q
D
I
L
D
T
L
E
D
N
R
N
W
Y
Q
A
M
I
P
---------
112
Fugue
65.48
11%
-51
- C3 -
2ACX
2
GRK6_HUMAN
A:
[14-532]
-------------
K
A
R
K
----------------
G
K
S
K
K
W
R
Q
M
L
Q
F
P
---
H
I
S
Q
C
E
E
L
R
L
S
L
---
E
R
-
D
Y
H
S
L
C
E
R
N
P
I
G
R
L
L
F
R
E
F
C
A
T
R
P
E
L
S
R
C
V
A
F
L
D
G
V
A
E
Y
E
V
T
-
P
D
-
D
K
R
K
A
C
G
-
R
N
L
T
Q
N
F
L
S
---
H
T
G
P
D
L
I
P
E
V
P
R
Q
--
L
V
T
N
C
T
Q
R
L
E
Q
G
P
C
K
D
L
-
F
Q
E
L
T
R
L
T
H
E
Y
L
S
V
A
P
F
A
-
D
------------
Y
L
D
S
I
Y
F
N
R
F
L
Q
W
K
W
L
E
R
----
Q
P
V
T
--
K
N
T
F
R
Q
Y
R
V
L
--
G
K
G
GF
G
E
V
C
A
C
Q
V
R
A
TG
K
M
Y
A
C
K
----
K
L
E
K
K
R
I
K
K
R
K
G
E
A
-
M
A
L
N
E
K
Q
I
L
E
K
V
N
S
R
F
V
V
S
L
A
Y
A
Y
-------
E
--
T
K
D
A
L
C
L
V
L
T
L
M
N
G
G
D
L
K
F
H
I
Y
H
MGQ
A
G
-----------
F
----
P
---
E
A
-
R
A
V
F
Y
A
A
E
I
C
C
G
L
--
E
D
L
H
R
E
R
I
V
Y
R
-
D
L
K
P
E
N
I
L
L
D
---
D
--
H
-
G
H
I
R
I
S
D
L
G
L
A
V
H
V
P
E
G
Q
T
I
K
G
RVGT
V
G
Y
M
A
P
E
V
V
K
N
E
R
Y
T
F
S
P
D
W
-----------
W
A
L
G
C
L
L
Y
E
M
I
A
GQSPFQQR
K
K
K
I
K
--
R
E
E
V
E
R
L
V
K
E
V
P
E
E
Y
S
E
R
F
S
P
Q
-
A
R
S
L
C
S
Q
L
L
C
K
D
P
A
E
R
L
GCR
G
G
S
A
R
E
V
K
E
H
P
L
F
K
K
L
N
F
K
R
L
G
A
GMLEPPFK
P
D
P
Q
A
I
Y
C
E
P
T
D
Q
D
F
Y
Q
K
F
A
T
G
S
V
P
I
P
W
Q
N
E
M
V
E
T
E
C
F
Q
E
L
N
VFGLDGS
1
PsiBlast_PDB
60.78
28%
15
- C3 -
4PED
1
ADCK3_HUMAN
A:
[4-279]
-------------------------------------------------------------------------------
A
N
A
E
R
I
V
R
T
L
C
K
V
R
G
A
A
L
K
L
G
Q
M
L
S
I
Q
D
------
D
A
F
I
N
P
H
L
A
K
I
F
E
R
V
R
Q
---
S
A
D
F
M
P
L
K
Q
M
M
K
T
--
L
N
N
D
L
G
P
N
W
R
D
K
L
E
Y
F
E
-
E
R
P
F
A
A
A
S
I
G
Q
V
H
L
A
R
M
K
-
G
------------
G
R
E
V
A
M
K
I
Q
Y
P
G
V
A
Q
S
I
N
----
S
D
V
N
N
L
M
A
V
L
N
M
S
N
M
L
--
P
E
G
-------
L
F
P
E
H
-----
L
I
D
----
V
L
R
R
E
L
A
L
E
C
D
Y
Q
R
-
E
A
A
C
A
R
K
F
R
D
L
L
K
G
H
P
F
F
Y
V
P
E
I
V
DE-----
L
--
C
S
P
H
V
L
-
T
T
E
L
V
S
G
F
P
L
D
Q
A
--
E
----
G
-----------
L
----
S
---
Q
E
I
R
N
E
I
C
Y
N
I
L
V
L
C
L
--
R
E
L
F
E
F
H
F
M
Q
T
-
D
P
N
W
S
N
F
F
Y
D
---
P
Q-
Q
-
H
K
V
A
L
L
D
F
G
A
T
R
E
Y
D
R
S
F
T
D
------
L
Y
I
Q
I
I
R
A
A
A
D
R
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------
122
HHSearch
59.25
18%
-68
- C3 -
4ZHX
2
?
A:
[27-312]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
------------
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
-
L
----
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
-------------------------------------------
L
F
-
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
--------------------
M
-
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
K
----
H
-----------
G
RVE-
E
---
M
E
-
A
R
R
L
F
Q
Q
I
L
S
A
-
V
--
D
Y
C
H
R
H
M
V
V
H
R
-
D
L
K
P
E
N
V
L
L
D
---
A
--
H
-
M
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
116
HHSearch
58.67
18%
-85
- C3 -
3TKI
2
CHK1_HUMAN
A:
[8-157]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
------------
E
E
A
V
A
V
K
I
V
D
M
K
--------------
N
I
K
K
E
I
C
I
N
K
-------------------------------------------
M
L
-
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
--------------------
L
-
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
P
----
D
-----------
I
GMP-
E
---
P
D
-
A
Q
R
F
F
H
Q
L
M
A
G
-
V
--
V
Y
L
H
G
I
G
I
T
H
R
-
D
I
K
P
E
N
L
L
L
D
---
E
--
R
-
D
N
L
K
I
S
D
F
G
L
A
T
V
F
R
Y
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
118
HHSearch
58.19
19%
-57
- C3 -
5D9H
2
STK39_MOUSE
A:
[18-184]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
A
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
------------
Q
E
R
V
A
I
K
R
I
N
L
E
K
C
Q
-------
T
S
M
D
E
L
L
K
E
I
Q
A
M
S
-------------------------------------------
Q
C
-
S
H
P
N
V
V
T
Y
Y
T
S
F
V
V
K
D
E
L
W
--------------------
L
-
V
M
K
L
L
S
G
G
S
M
L
D
I
I
K
Y
----
I
V
N
R
GEHKNGVL
E
----
E
---
A
I
-
I
A
T
I
L
K
E
V
L
E
G
-
L
--
D
Y
L
H
R
N
G
Q
I
H
R
-
D
L
K
A
G
N
I
L
L
G
---
E
--
D
-
G
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
128
HHSearch
58.06
18%
-74
- C3 -
5IG1
2
?
A:
[22-171]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
S
V
I
G
K
G
A
F
S
T
V
H
R
C
V
N
K
R
T
------------
G
E
V
C
A
V
K
V
I
A
L
K
S
L
R
--
S
----
S
E
I
N
K
I
K
R
E
I
G
I
C
S
-------------------------------------------
S
L
-
Q
H
E
H
I
V
S
M
R
R
A
F
R
D
E
S
H
F
Y
--------------------
L
-
V
F
E
Y
V
S
G
G
E
L
F
D
E
I
V
T
----
R
-----------
K
FYN-
E
---
K
D
-
A
S
A
C
M
H
Q
I
L
S
A
-
L
--
Q
H
C
H
S
K
N
I
I
H
R
-
D
L
K
P
E
N
L
L
L
A
SKD
P
--
N
-
A
P
V
K
I
T
D
F
G
L
A
V
I
M
E
Q
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
125
HHSearch
57.23
16%
-68
- C3 -
4AW2
3
MRCKA_RAT
A:
[75-245]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
F
E
I
L
K
V
I
G
R
G
A
F
G
E
V
A
V
V
K
L
K
N
A
------------
D
K
V
F
A
M
K
I
L
N
K
W
E
M
L
K
-
R
----
A
E
T
A
C
F
R
E
E
R
D
V
L
V
-------------------------------------------
N
G
-
D
S
K
W
I
T
T
L
H
Y
A
F
Q
D
D
N
N
L
Y
--------------------
L
-
V
M
D
Y
Y
V
G
G
D
L
L
T
L
L
S
K
----
F
EDRL-------
P
----
E
---
E
M
-
A
R
F
Y
L
A
E
M
V
I
A
-
I
--
D
S
V
H
Q
L
H
Y
V
H
R
-
D
I
K
P
D
N
I
L
M
D
---
M
--
N
-
G
H
I
R
L
A
D
F
G
S
C
L
K
L
M
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
HHSearch
57.22
17%
-74
- C3 -
3UTO
1
UNC22_CAEEL
A:
[157-309]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
H
Y
D
I
H
E
E
L
G
T
G
A
F
G
V
V
H
R
V
T
E
R
A
T
------------
G
N
N
F
A
A
K
F
V
M
T
P
H
E
--------
S
D
K
E
T
V
R
K
E
I
Q
T
M
S
-------------------------------------------
V
L
-
R
H
P
T
L
V
N
L
H
D
A
F
E
D
D
N
E
M
V
--------------------
M
-
I
Y
E
F
M
S
G
G
E
L
F
E
K
V
A
D
----
E
H
N
K
M
-------
S
----
E
---
D
E
-
A
V
E
Y
M
R
Q
V
C
K
G
-
L
--
C
H
M
H
E
N
N
Y
V
H
L
-
D
L
K
P
E
N
I
M
F
T
---
T
KR
S
-
N
E
L
K
L
I
D
F
G
L
T
A
H
L
D
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
111
Fugue
57.14
23%
-9
- C1 -
4O6D
8
?
A:
[19-377]
LYFQS
N
A
D
T
G
C
A
I
D
I
S
R
Q
E
L
R
C
G
S
G
V
F
I
H
N
DVE
A
W
M
D
R
Y
K
Y
Y
P
E
T
P
Q
G
L
A
K
I
I
Q
K
A
H
K
E
G
V
---
C
G
L
R
S
V
S
R
L
E
H
Q
M
W
E
A
V
K
D
E
L
N
T
L
L
K
E
N
-------
G
V
D
L
S
V
V
V
------
E
K
Q
E
G
M
Y
-
K
S
A
P
K
R
L
T
A
---
T
A
N
N
------
T
F
V
--
V
D
G
P
E
T
K
E
C
P
T
Q
N
R
A
W
N
-
S
L
E
V
E
D
F
G
F
G
L
--------
T
------------
S
T
R
M
F
L
K
V
R
E
S
N
T
T
E
C
D
S
----
K
I
I
G
T
A
V
K
--------------------------------
N
----
N
L
A
I
H
S
D
--
L
S
Y
W
I
-
E
S
R
L
----------
N
D
T
W
K
L
E
R
A
V
-------
L
--
G
E
V
K
S
C
---
T
W
P
E
T
H
T
L
W
G
---
D
----
G
-----------
I
----
L
---
E
S
-
D
L
I
I
P
V
T
L
A
G
P
R
S
--
N
H
N
R
R
P
G
Y
K
T
Q
-
N
Q
G
P
-----
W
---
D
--
E
-
G
R
V
E
I
-
D
F
D
Y
-
C
P
---------------
G
T
T
V
T
L
S
-----------------------
E
S
C
G
--
H
R
-----------
G
P
-------------------------------
A
T
R
------
T
T
T
E
S
---
G
K
L
I
T
D
W
C
C
-
R
S
C
T
L
P
---------------
P
L
R
Y
Q
T
D
S
G
---
C
W
Y
G
M
E
I
R
P
Q
R
H
D
E
K
T
L
V
Q
S
Q
V
N
A
-------------
121
HHSearch
57.01
15%
-81
- C3 -
2Y7J
1
PHKG2_HUMAN
A:
[93-252]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
Q
K
Y
D
P
K
D
V
I
G
R
G
V
S
S
V
V
R
R
C
V
H
R
A
T
------------
G
H
E
F
A
V
K
I
M
E
V
T
A
E
R
L
S
P
E
Q
L
E
E
V
R
E
A
T
R
R
E
T
H
I
L
R
-------------------------------------------
Q
V
A
G
H
P
H
I
I
T
L
I
D
S
Y
E
S
S
S
F
M
F
--------------------
L
-
V
F
D
L
M
R
K
G
E
L
F
D
Y
L
T
E
----
K
-----------
V
ALS-
E
---
K
E
-
T
R
S
I
M
R
S
L
L
E
A
-
V
--
S
F
L
H
A
N
N
I
V
H
R
-
D
L
K
P
E
N
I
L
L
D
---
D
--
N
-
M
Q
I
R
L
S
D
F
G
F
S
C
H
L
E
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
105
Fugue
56.60
15%
-40
- C3 -
3UQC
-
MVIN_MYCTU
A:
[20-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
L
V
----
P
G
A
R
I
A
N
G
R
Y
R
L
L
I
F
H
GG
V
P
P
-------
L
Q
F
W
Q
-----
A
L
D
TALD
R
Q
V
A
L
T
F
V
D
P
Q
G
V
L
-
P
D
D
V
L
Q
E
T
L
S
R
T
L
R
L
S
R
I
D
K
P
G
V
A
RVL
D
V
V
H
T
--
R
A
G
G
L
V
-
V
A
E
W
I
R
G
G
S
L
Q
E
V
A
D
T
----
S
-----------
P
----
S
---
P
V
-
G
A
I
R
A
M
Q
S
L
A
A
A
A
--
D
A
A
H
R
A
G
V
A
L
S
-
I
D
H
P
S
R
V
R
V
S
---
I
--
D
-
G
D
V
V
L
A
Y
P
A
T
M
P
D
A
------------
N
P
Q
D
D
I
R
G
I
G
A
S
L
Y
A
L
L
V
N
R
WPLPEAGVRSG
L
A
P
A
E
R
D
T
A
-----------
G
Q
P
I
E
--
P
A
D
I
D
R
D
I
P
----
F
Q
I
S
A
V
A
A
R
-
S
V
Q
G
D
G
G
I
R
S
A
S
T
L
L
N
L
---
M
Q
Q
A
T
A
--------------------------------------------------------------------------
136
HHSearch
56.51
19%
-73
- C3 -
1KOB
1
?
A:
[51-203]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
T
------------
G
R
V
F
V
A
K
F
I
N
T
P
Y
P
--------
L
D
K
Y
T
V
K
N
E
I
S
I
M
N
-------------------------------------------
Q
L
-
H
H
P
K
L
I
N
L
H
D
A
F
E
D
K
Y
E
M
V
--------------------
L
-
I
L
E
F
L
S
G
G
E
L
F
D
R
I
A
A
----
E
-----------
D
YKMS
E
---
A
E
-
V
I
N
Y
M
R
Q
A
C
E
G
-
L
--
K
H
M
H
E
H
S
I
V
H
L
-
D
I
K
P
E
N
I
M
C
E
---
T
KK
A
-
S
S
V
K
I
I
D
F
G
L
A
T
K
L
N
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
117
HHSearch
56.34
17%
-60
- C3 -
4CZU
4
CIPKN_ARATH
A:
[16-167]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
------------
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
K
-
N
----
K
M
I
A
Q
I
K
R
E
I
S
T
M
K
-------------------------------------------
L
I
-
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
--------------------
F
-
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
S
----
N
-----------
G
RLK-
E
---
D
E
-
A
R
K
Y
F
Q
Q
L
I
N
A
-
V
--
D
Y
C
H
S
R
G
V
Y
H
R
-
D
L
K
P
E
N
L
L
L
D
---
A
--
N
-
G
A
L
K
V
S
D
F
G
L
S
A
L
P
Q
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
124
HHSearch
55.87
18%
-71
- C3 -
4FR4
2
ST32A_HUMAN
A:
[14-177]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
H
F
E
I
L
R
A
I
G
K
G
S
F
G
K
V
C
I
V
Q
K
N
D
T
------------
K
K
M
Y
A
M
K
Y
M
N
K
Q
K
C
V
E
-
R
----
N
E
V
R
N
V
F
K
E
L
Q
I
M
Q
-------------------------------------------
G
L
-
E
H
P
F
L
V
N
L
W
Y
S
F
Q
D
E
E
D
M
F
--------------------
M
-
V
V
D
L
L
L
G
G
D
L
R
Y
H
L
Q
Q
----
N
-----------
V
----
H
F
K
E
E
T
-
V
K
L
F
I
C
E
L
V
M
A
-
L
--
D
Y
L
Q
N
Q
R
I
I
H
R
-
D
M
K
P
D
N
I
L
L
D
---
E
--
H
-
G
H
V
H
I
T
D
F
N
I
A
A
M
L
P
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
132
HHSearch
55.80
18%
-68
- C3 -
2VD5
1
DMPK_HUMAN
A:
[66-230]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
K
V
I
G
R
G
A
F
S
E
V
A
V
V
K
M
K
Q
T
------------
G
Q
V
Y
A
M
K
I
M
N
K
W
D
M
L
K
-
R
----
G
E
V
S
C
F
R
E
E
R
D
V
L
V
-------------------------------------------
N
G
-
D
R
R
W
I
T
Q
L
H
F
A
F
Q
D
E
N
Y
L
Y
--------------------
L
-
V
M
E
Y
Y
V
G
G
D
L
L
T
L
L
S
K
----
F
-----------
G
ERIP
A
---
E
M
-
A
R
F
Y
L
A
E
I
V
M
A
-
I
--
D
S
V
H
R
L
G
Y
V
H
R
-
D
I
K
P
D
N
I
L
L
D
---
R
--
C
-
G
H
I
R
L
A
D
F
G
S
C
L
K
L
R
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
130
HHSearch
55.11
16%
-71
- C3 -
3V8S
1
ROCK1_HUMAN
A:
[69-220]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
E
D
Y
E
V
V
K
V
I
G
R
G
A
F
G
E
V
Q
L
V
R
H
K
S
T
------------
R
K
V
Y
A
M
K
L
L
S
K
F
E
M
I
K
-
R
----
S
D
S
A
F
F
W
E
E
R
D
I
M
A
-------------------------------------------
F
A
-
N
S
P
W
V
V
Q
L
F
Y
A
F
Q
D
D
R
Y
L
Y
--------------------
M
-
V
M
E
Y
M
P
G
G
D
L
V
N
L
M
S
N
----
Y
-----------
D
VP--
E
---
K
W
-
A
R
F
Y
T
A
E
V
V
L
A
-
L
--
D
A
I
H
S
M
G
F
I
H
R
-
D
V
K
P
D
N
M
L
L
D
---
K
--
S
-
G
H
L
K
L
A
D
F
G
T
C
M
K
M
N
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
126
HHSearch
54.66
22%
-65
- C3 -
4FIE
1
PAK4_HUMAN
A:
[156-299]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
------------
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
--------
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
-------------------------------------------
D
Y
-
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
--------------------
V
-
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
H
----
T
-----------
R
M
N
--
E
---
E
Q
-
I
A
A
V
C
L
A
V
L
Q
A
-
L
--
S
V
L
H
A
Q
G
V
I
H
R
-
D
I
K
S
D
S
I
L
L
T
---
H
--
D
-
G
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
K
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
106
Fugue
54.12
12%
-46
- C3 -
1TQM
1
RIO2_ARCFU
A:
[1-282]
------------------------------------------------------------------------------------------------------
M
N
I
A
E
L
Y
-
G
K
M
G
K
H
S
W
R
I
-
M
D
A
I
F
K
N
L
W
---
D
Y
E
Y
V
P
L
Q
L
I
S
S
H
A
R
I
G
E
E
K
A
R
N
I
L
K
Y
L
S
D
L
R
-
V
V
Q
N
R
Q
K
D
Y
E
G
S
T
F
T
F
I
G
-
L
------------
S
L
Y
S
L
H
R
L
V
R
S
G
K
V
D
A
I
G
----
K
L
M
G
E
G
K
E
S
A
V
F
N
C
Y
S
--
E
K
F
-------
G
E
C
V
V
-----
K
F
H
----
K
V
K
V
K
E
H
F
S
V
L
A
I
R
-
S
A
R
N
E
F
R
A
L
Q
K
L
Q
G
L
A
---
V
P
K
V
Y
-------
A
--
W
E
G
N
A
V
-
L
M
E
L
I
D
A
K
E
L
Y
R
V
-------
R
-----------
V
----
E
---
N
P
-
D
E
V
L
D
M
I
L
E
E
V
A
K
--
F
Y
H
R
--
G
I
V
H
G
-
D
L
S
Q
Y
N
V
L
V
S
---
E
--
E
-
G
-
I
W
I
I
D
F
P
Q
S
V
E
V
G
E
E
-------------
G
W
R
E
I
L
E
R
D
V
R
N
I
I
T
Y
-----------
F
S
R
T
Y
R
T
E
K
-----------
D
I
N
S
A
--
I
D
R
I
L
Q
E
--------------------------------------------------------------------------------------------------------------------