@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3211: (2016-05-17 )
MTAVKHTTESTFAKLGVRDEIVRALGEEGIKRPFAIQELTLPLALDGEDVIGQARTGMGKTFAFGVPLLQRITSGDGTRPLTGAPRALVVVPTRELCLQVTDDLATAGKYLTAGPDTDDAAAVRRRLSVVSIYGGRPYEPQIEALRAGADVVVGTPGRLLDLCQQGHLQLGGLSVLVLDEADEMLDLGFLPDIERILRQIPADRQSMLFSATMPDPIITLARTFMVRPTHIRAEAPHSSAVHDATEQFVYRAHALDKVELVSRVLQARDRGATMIFTRTKRTAQKVADELTERGFAVGAVHGDLGQLAREKALKAFRTGGIDVLVATDVAARGIDIDDVTHVINYQCPEDEKMYVHRIGRTGRAGRTGVAVTLVDWDELPRWSMIDQALGLGSPDPAETYSNSPHLYAELAIPATAGGTVGPARKSQGRRRDTDCDGQKTAQHARNTPRRRRTRGGKPVTGHPGTNPISSPIVGGDATSEPGSGTASDSGSDVVSGSRSGNGEAARRRRRRRRRPTHAQDGFAARAN
Atome Classification :
(60 SA)
.........10-----.........20........30........40......--.-.50........60........70.-------.-.------....------------.80.---------....---...90........100.......110.........120.......130.......140...-....-150.......160....-.-.-..170.......180...-.-.-..190-.......----200---..--......210.......220.......230.......240.......250-.-...----.-----...260......-.270-.......280.......290.......300.......310.......320.......330.......340.......------350-----........360.......370..-.....-380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTAVKHT
T
E
S
------
T
F
A
KLG
V
R
D
E
I
V
R
A
L
G
E
EGIKRPF
A
I
Q
EL
T
L
P
L
A
LD
G
--
E
-
D
V
IGQARTGMGK
T
F
A
F
G
V
P
L
L
Q
R
I
-------T-S------GDGT------------RPLT---------GA
P
R
---
A
L
V
V
V
P
T
R
E
L
C
L
Q
V
T
D
D
L
A
TAG
K
Y
--
L
TAGPDT
D
D
A
A
A
V
R
R
R
L
S
V
V
S
IYGGRPYE
P
Q
I
E
A
L
-RAGA-
D
V
V
VGT
P
G
R
L
L
D
-
L
C
Q
Q-G-H-
L
Q
LG
G
L
S
V
L
V
LDEA
D
E
M
L-D-L-GF
L
P
D
-
I
E
R
I
L
R
Q----IP----A
D
--
R
Q
S
M
L
F
SATMP
D
P
I
I
T
L
A
R
T
FMVRPT
H
I
R
AEAPHS
S
A
V
H
D
A
T
E
Q
F
V
Y
-
R
-
A
-HAL----
D
-----
K
V
E
L
V
S
R
V
L
Q
AR-DRG
A
-
T
M
I
F
T
R
T
K
R
T
A
Q
K
V
A
D
E
L
T
ERG
F
A
V
G
AVH
G
D
L
G
Q
L
A
R
E
K
A
L
K
A
F
RTGG
I
D
V
L
V
ATDVAARGI
D
I
D
D
V
T
H
V
I
NYQCPE------DE------
K
M
Y
V
H
RIGRTGRAGR
T
G
V
A
V
T
LV-
D
W
D
EL-P
R
W
S
M
I
D
Q
A
LGLGSP
D
P
A
E
TYSNSP
H
L
Y
A
E
L
AIPATAGGTVGP
A
R
KSQGRRRDTDCD
G
Q
K
T
A
Q
H
A
RNT
P
R
R
RRTRGGKPVTGHPGTNPISSPIVGGDATSEPGSGTASDSGSDVVSGSRSG
N
G
E
A
A
R
R
R
R
R
RRRRPTHAQDGFAARAN
113
HHSearch
87.38
39%
-121
- C4 -
1HV8
5
H669_METJA
A:
[4-359]
-------
E
Y
M
------
N
F
N
E
L
N
L
S
D
N
I
L
N
A
I
R
N
K
G
F
E
K
P
T
D
I
Q
M
K
V
I
P
L
F
L
N
D
E-
Y
-
N
I
V
A
Q
A
R
T
G
S
G
K
T
A
S
F
A
I
P
L
I
E
L
V
-------
N
-
E
------
N
----------------------------
N
G
I
E
---
A
I
I
L
T
P
T
R
E
L
A
I
Q
V
A
D
E
I
E
S
L
K
G
N
--
K
--------------
N
L
K
I
A
K
I
Y
G
G
K
A
I
Y
P
Q
I
-
K
A
-
L
K
N
A
-
N
I
V
V
G
T
P
G
R
I
L
D
-
H
I
N
R
-
G
-
T
-
L
N
L
K
N
V
K
Y
F
I
L
D
E
A
D
E
M
L
-
N
-
M
-
G
F
I
K
D
-
V
E
K
I
L
N
A
----
C
N
----
K
D
--
K
R
I
L
L
F
S
A
T
M
P
R
E
I
L
N
L
A
K
K
Y
M
G
D
Y
S
F
I
K
A
K
I
------
N
A
N
I
E
Q
S
Y
V
-
E
-
V
-
N
E
N
----
E
-----
R
F
E
A
L
C
R
L
L
K
N
--
K
E
F
Y
-
G
L
V
F
C
K
T
K
R
D
T
K
E
L
A
S
M
L
R
D
I
G
F
K
A
G
A
I
H
G
D
L
S
Q
S
Q
R
E
K
V
I
R
L
F
K
Q
K
K
I
R
I
L
I
A
T
D
V
M
S
R
G
I
D
V
N
D
L
N
C
V
I
N
Y
H
L
P
Q
------
N
P
------
E
S
Y
M
H
R
I
G
R
T
G
R
A
G
K
K
G
K
A
I
S
I
I
-
N
R
R
E
Y
-
K
K
L
R
Y
I
E
R
A
M
K
L
----------------------------------------------------------------------------------------------------------------------------------------
111
HHSearch
86.04
44%
-112
- C4 -
4KBF
3
?
A:
[1-357]
---------
M
------
E
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
-------
A
-
P
------
S
Q
E
---------------
R
G
---------
R
K
P
R
---
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
A
V
A
P
H
------------------
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
-
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
-
G
-
V
-
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
-
M
-
G
F
E
E
E
-
V
E
A
L
L
S
A
----
T
P
----
P
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
N
V
I
K
D
E
P
--
V
T
Y
E
--
E
E
A
V
-
P
-
A
-
P
V
R
----
G
-----
R
L
E
V
L
S
D
L
L
Y
V
A
-
S
P
D
R
-
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
------
R
A
------
E
A
Y
Q
H
R
S
G
R
T
G
R
A
G
R
G
G
R
V
V
L
L
Y
-
G
P
R
E
R
-
R
D
V
E
A
L
E
R
A
V
------------------------------------------------------------------------------------------------------------------------------------------
99
HHSearch
85.46
33%
-104
- C4 -
4D25
4
?
A:
[46-421]
-----
P
R
P
I
E
------
S
F
E
T
A
N
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
G
--
R
-
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
M
L
-------
L
-
Q
------
D
P
K
D
L
I
S
---------
E
N
G
C
---------
A
Q
P
Q
---
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
A
R
K
F
S
Y
G
--
S
--------------
V
L
K
V
A
V
A
Y
G
G
T
A
V
R
H
Q
G
D
N
I
-
A
R
G
C
-
H
I
L
V
A
T
P
G
R
L
H
D
-
F
V
E
R
-
N
-
R
-
V
S
F
G
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
-
D
-
M
-
G
F
M
P
S
-
I
E
K
M
M
L
H
PTMV
E
T
----
T
K
--
R
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
N
N
Y
L
F
V
A
V
G
I
V
G
--
G
A
S
T
D
V
E
Q
I
F
I
-
E
-
V
-
T
K
Y
----
E
-----
K
R
N
S
L
K
Q
L
I
E
E
N
-
D
G
K
R
-
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
------
S
I
------
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
-
D
S
D
Q
D
L
A
L
V
A
D
L
S
K
I
L
------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
85.25
36%
-126
- C4 -
1HV8
5
H669_METJA
A:
[7-356]
----------------
N
F
N
E
L
N
L
S
D
N
I
L
N
A
I
R
N
K
G
F
E
K
P
T
D
I
Q
M
K
V
I
P
L
F
L
N
D
--
E
Y
N
I
V
A
Q
A
R
T
G
S
G
K
T
A
S
F
A
I
P
L
I
E
L
V
-------
N
-
E
------
N
N
G
I
------------
E
-------------------
A
I
I
L
T
P
T
R
E
L
A
I
Q
V
A
D
E
I
----------------
E
S
L
K
G
N
K
N
L
K
I
A
K
I
Y
G
G
K
A
I
Y
P
Q
I
K
A
L
-
K
-
N
A
-
N
I
V
V
G
T
P
G
R
I
L
D
-
H
I
N
R
-
G
-
T
-
L
N
L
K
N
V
K
Y
F
I
L
D
E
A
D
E
M
L
-
N
-
M
-
G
F
I
K
D
-
V
E
K
I
L
N
A
----
C
N
----
K
D
--
K
R
I
L
L
F
S
A
T
M
P
R
E
I
L
N
L
A
K
K
Y
M
G
D
Y
S
F
I
K
A
K
------
I
N
A
N
I
E
Q
S
Y
V
-
E
-
V
-
N
E
N
----
E
-----
R
F
E
A
L
C
R
L
L
K
N
K
-
E
F
Y
G
--
L
V
F
C
K
T
K
R
D
T
K
E
L
A
S
M
L
R
D
I
G
F
K
A
G
A
I
H
G
D
L
S
Q
S
Q
R
E
K
V
I
R
L
F
K
Q
K
K
I
R
I
L
I
A
T
D
V
M
S
R
G
I
D
V
N
D
L
N
C
V
I
N
Y
H
L
P
Q
------
N
P
------
E
S
Y
M
H
R
I
G
R
T
G
R
A
G
K
K
G
K
A
I
S
I
I
-
N
R
R
E
Y
-
K
K
L
R
Y
I
E
R
A
-------------------------------------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
84.24
33%
-113
- C4 -
3EX7
4
IF4A3_HUMAN
H:
[23-386]
M
T
K
V
E
F
E
T
S
E
EVDVTP
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
--
R
-
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
-------
D
-
I
------
Q
------------------
V
---------
R
E
T
Q
---
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
--
M
N
--------------
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
Y
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
-
M
I
R
R
-
R
-
S
-
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
-
K
-
G
F
K
E
Q
-
I
Y
D
V
Y
R
Y
----
L
P
----
P
A
--
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
--
I
R
I
L
V
K
R
D
E
L
T
L
E
G
I
K
Q
F
F
V
-
A
-
V
-
E
R
E
----
E
W----
K
F
D
T
L
C
D
L
Y
D
T
L
-
T
I
T
Q
-
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
-
K
N
D
D
I
-----------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
84.22
33%
-112
- C4 -
2XB2
4
IF4A3_HUMAN
A:
[23-386]
M
T
K
V
E
F
E
T
S
E
E
V
D
V
T
P
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
--
R
-
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
-------
D
-
I
------
Q
------------------
V
---------
R
E
T
Q
---
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
--
M
N
--------------
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
Y
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
-
M
I
R
R
-
R
-
S
-
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
-
K
-
G
F
K
E
Q
-
I
Y
D
V
Y
R
Y
----
L
P
----
P
A
--
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
--
I
R
I
L
V
K
R
D
E
L
T
L
E
G
I
K
Q
F
F
V
-
A
-
V
-
E
R
E
----
E
W
----
K
F
D
T
L
C
D
L
Y
D
T
L
-
T
I
T
Q
-
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
-
K
N
D
D
I
-----------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
84.21
33%
-114
- C4 -
2HYI
3
IF4A3_HUMAN
C:
[23-386]
M
T
K
V
E
F
E
T
S
E
E
V
D
V
T
P
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
--
R
-
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
-------
D
-
I
------
Q
------------------
V
---------
R
E
T
Q
---
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
--
M
N
--------------
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
Y
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
-
M
I
R
R
-
R
-
S
-
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
-
K
-
G
F
K
E
Q
-
I
Y
D
V
Y
R
Y
----
L
P
----
P
A
--
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
--
I
R
I
L
V
K
R
D
E
L
T
L
E
G
I
K
Q
F
F
V
-
A
-
V
-
E
R
E
----
E
W
----
K
F
D
T
L
C
D
L
Y
D
T
L
-
T
I
T
Q
-
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
-
K
N
D
D
I
-----------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
84.13
33%
-110
- C4 -
2HYI
3
IF4A3_HUMAN
I:
[23-386]
M
T
K
V
E
F
E
T
S
E
EVDVTP
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
--
R
-
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
-------
D
-
I
------
Q
------------------
V
---------
R
E
T
Q
---
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
--
M
N
--------------
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
Y
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
-
M
I
R
R
-
R
-
S
-
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
-
K
-
G
F
K
E
Q
-
I
Y
D
V
Y
R
Y
----
L
P
----
P
A
--
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
--
I
R
I
L
V
K
R
D
E
L
T
L
E
G
I
K
Q
F
F
V
-
A
-
V
-
E
R
E
----
E
W----
K
F
D
T
L
C
D
L
Y
D
T
L
-
T
I
T
Q
-
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
-
K
N
D
D
I
-----------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
84.01
33%
-112
- C4 -
2J0S
3
IF4A3_HUMAN
A:
[22-385]
M
T
K
V
E
F
E
T
S
E
E
V
D
V
T
P
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
--
R
-
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
-------
D
-
I
------
Q
------------------
V
---------
R
E
T
Q
---
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
--
M
N
--------------
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
Y
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
-
M
I
R
R
-
R
-
S
-
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
-
K
-
G
F
K
E
Q
-
I
Y
D
V
Y
R
Y
----
L
P
----
P
A
--
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
--
I
R
I
L
V
K
R
D
E
L
T
L
E
G
I
K
Q
F
F
V
-
A
-
V
-
E
R
E
----
E
W
----
K
F
D
T
L
C
D
L
Y
D
T
L
-
T
I
T
Q
-
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
-
K
N
D
D
I
-----------------------------------------------------------------------------------------------------------------------------------------------------
102
HHSearch
83.85
32%
-117
- C4 -
1S2M
-
DHH1_YEAST
A:
[46-406]
---------
N
------
T
F
E
D
F
Y
L
K
R
E
L
L
M
G
I
F
E
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
P
V
A
I
T
G
--
R
-
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
E
K
V
-------
K
-
P
------
K
L
---------------------------
N
K
I
Q
---
A
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
R
T
L
G
K
H
--
C
--------------
G
I
S
C
M
V
T
T
G
G
T
N
L
R
D
D
I
L
R
L
-
N
E
T
V
-
H
I
L
V
G
T
P
G
R
V
L
D
-
L
A
S
R
-
K
-
V
-
A
D
L
S
D
C
S
L
F
I
M
D
E
A
D
K
M
L
-
S
-
R
-
D
F
K
T
I
-
I
E
Q
I
L
S
F
----
L
P
----
P
T
--
H
Q
S
L
L
F
S
A
T
F
P
L
T
V
K
E
F
M
V
K
H
L
H
K
P
Y
E
I
N
L
M
E
E
---
L
T
L
K
G
I
T
Q
Y
Y
A
-
F
-
V
-
E
E
R
----
Q
-----
K
L
H
C
L
N
T
L
F
S
K
L
-
Q
I
N
Q
-
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
D
L
G
Y
S
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
------
T
A
------
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
-
N
W
N
D
R
-
F
N
L
Y
K
I
E
Q
E
L
G
T
E
I
--------------------------------------------------------------------------------------------------------------------------------------
97
HHSearch
83.84
36%
-104
- C4 -
4PXA
5
DDX3X_HUMAN
A:
[62-446]
------
P
H
I
E
------
S
F
S
D
V
E
M
G
E
I
I
M
G
N
I
E
L
T
R
Y
T
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
K
--
R
-
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
-------
Y
-
S
------
D
G
P
G
E
A
L
R
A
M
K
E
NGRY
G
R
R
K
---------
Q
Y
P
I
---
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
A
R
K
F
S
Y
R
--
S
--------------
R
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
R
G
C
-
H
L
L
V
A
T
P
G
R
L
V
D
-
M
M
E
R
-
G
-
K
-
I
G
L
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
V
-
M
-
G
F
E
P
Q
-
I
R
R
I
V
E
Q
----
D
T
MPPK
G
V
--
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
A
V
G
R
V
G
--
S
T
S
E
N
I
T
Q
K
V
V
-
W
-
V
-
E
E
S
----
D
-----
K
R
S
F
L
L
D
L
L
N
A
T
G
K
D
S
L
-
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
I
------
E
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
F
F
-
N
E
R
N
I
-
N
I
T
K
D
L
L
D
L
L
V
-----------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
83.79
33%
-111
- C4 -
3EX7
4
IF4A3_HUMAN
C:
[23-386]
M
T
K
V
E
F
E
T
S
E
E
V
D
V
T
P
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
--
R
-
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
-------
D
-
I
------
Q
------------------
V
---------
R
E
T
Q
---
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
--
M
N
--------------
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
Y
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
-
M
I
R
R
-
R
-
S
-
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
-
K
-
G
F
K
E
Q
-
I
Y
D
V
Y
R
Y
----
L
P
----
P
A
--
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
--
I
R
I
L
V
K
R
D
E
L
T
L
E
G
I
K
Q
F
F
V
-
A
-
V
-
E
R
E
----
E
W----
K
F
D
T
L
C
D
L
Y
D
T
L
-
T
I
T
Q
-
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
-
K
N
D
D
I
-----------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
83.76
33%
-109
- C4 -
2J0Q
3
IF4A3_HUMAN
B:
[22-385]
M
T
K
V
E
F
E
T
S
E
EVDVTP
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
--
R
-
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
-------
D
-
I
------
Q
------------------
V
---------
R
E
T
Q
---
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
--
M
N
--------------
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
Y
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
-
M
I
R
R
-
R
-
S
-
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
-
K
-
G
F
K
E
Q
-
I
Y
D
V
Y
R
Y
----
L
P
----
P
A
--
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
--
I
R
I
L
V
K
R
D
E
L
T
L
E
G
I
K
Q
F
F
V
-
A
-
V
-
E
R
E
----
E
W----
K
F
D
T
L
C
D
L
Y
D
T
L
-
T
I
T
Q
-
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
-
K
N
D
D
I
-----------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
83.64
33%
-108
- C4 -
2J0Q
3
IF4A3_HUMAN
A:
[22-385]
M
T
K
V
E
F
E
T
S
E
E
V
D
V
T
P
T
F
D
T
M
G
L
R
E
D
L
L
R
G
I
Y
A
Y
G
F
E
K
P
S
A
I
Q
Q
R
A
I
K
Q
I
I
K
G
--
R
-
D
V
I
A
Q
S
Q
S
G
T
G
K
T
A
T
F
S
I
S
V
L
Q
C
L
-------
D
-
I
------
Q
------------------
V
---------
R
E
T
Q
---
A
L
I
L
A
P
T
R
E
L
A
V
Q
I
Q
K
G
L
L
A
L
G
D
Y
--
M
N
--------------
V
Q
C
H
A
C
I
G
G
T
N
V
G
E
D
I
R
K
L
-
D
Y
G
Q
-
H
V
V
A
G
T
P
G
R
V
F
D
-
M
I
R
R
-
R
-
S
-
L
R
T
R
A
I
K
M
L
V
L
D
E
A
D
E
M
L
-
N
-
K
-
G
F
K
E
Q
-
I
Y
D
V
Y
R
Y
----
L
P
----
P
A
--
T
Q
V
V
L
I
S
A
T
L
P
H
E
I
L
E
M
T
N
K
F
M
T
D
P
--
I
R
I
L
V
K
R
D
E
L
T
L
E
G
I
K
Q
F
F
V
-
A
-
V
-
E
R
E
----
E
W
----
K
F
D
T
L
C
D
L
Y
D
T
L
-
T
I
T
Q
-
A
V
I
F
C
N
T
K
R
K
V
D
W
L
T
E
K
M
R
E
A
N
F
T
V
S
S
M
H
G
D
M
P
Q
K
E
R
E
S
I
M
K
E
F
R
S
G
A
S
R
V
L
I
S
T
D
V
W
A
R
G
L
D
V
P
Q
V
S
L
I
I
N
Y
D
L
P
N
------
N
R
------
E
L
Y
I
H
R
I
G
R
S
G
R
Y
G
R
K
G
V
A
I
N
F
V
-
K
N
D
D
I
-----------------------------------------------------------------------------------------------------------------------------------------------------
110
HHSearch
83.28
32%
-111
- C4 -
3FHT
4
DD19B_HUMAN
A:
[22-394]
------
Y
S
V
K
------
S
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
E
P
P
Q
-
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
V
-------
E
-
P
------
A
N
---------------------------
K
Y
P
Q
---
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
--
Y
P
-------------
E
L
K
L
A
Y
A
V
R
G
N
K
---
L
E
R
G
Q
-
K
I
S
E
-
Q
I
V
I
G
T
P
G
T
V
L
D
-
W
C
S
K
-
L
K
F
-
I
D
P
K
K
I
K
V
F
V
L
D
E
A
D
V
M
I
-
A
-
T
Q
G
H
Q
D
Q
-
S
I
R
I
Q
R
M
----
L
P
----
R
N
--
C
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
E
--
E
T
L
D
T
I
K
Q
Y
Y
V
-
L
C
S
-
S
R
D
----
E
-----
K
F
Q
A
L
C
N
L
Y
G
A
I
-
T
I
A
Q
-
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
DKDGNP
D
N
------
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
-
D
S
K
H
S
M
N
I
L
N
R
I
Q
E
H
F
N
K
----------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
83.02
33%
-135
- C4 -
2VSO
1
IF4A_YEAST
A:
[24-364]
-----------------
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
G
--
H
-
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
-------
D
-
T
------
S
------------------
V
---------
K
A
P
Q
---
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
----------------
A
L
A
F
H
M
D
I
K
V
H
A
C
I
G
----------
L
-
R
-
D
A
-
Q
I
V
V
G
T
P
G
R
V
F
D
-
N
I
Q
R
-
R
-
R
-
F
R
T
D
K
I
K
M
F
I
L
D
E
A
D
E
M
L
-
S
-
S
-
G
F
K
E
Q
-
I
Y
Q
I
F
T
L
----
L
P
----
P
T
--
T
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
E
L
T
L
--
E
G
I
K
Q
F
Y
V
-
N
-
V
-
E
E
E
----
E
Y----
K
Y
E
C
L
T
D
L
Y
D
S
I
-
S
V
T
Q
-
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
K
------
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
82.95
31%
-118
- C4 -
1S2M
-
DHH1_YEAST
A:
[46-403]
---------
N
------
T
F
E
D
F
Y
L
K
R
E
L
L
M
G
I
F
E
A
G
F
E
K
P
S
P
I
Q
E
E
A
I
P
V
A
I
T
G
--
R
-
D
I
L
A
R
A
K
N
G
T
G
K
T
A
A
F
V
I
P
T
L
E
K
V
--------------------------------
K
P
K
L
---------
N
K
I
Q
---
A
L
I
M
V
P
T
R
E
L
A
L
Q
T
S
Q
V
V
R
T
L
G
K
H
--
C
G
--------------
I
S
C
M
V
T
T
G
G
T
N
L
R
D
D
I
L
R
L
-
N
E
T
V
-
H
I
L
V
G
T
P
G
R
V
L
D
-
L
A
S
R
-
K
-
V
-
A
D
L
S
D
C
S
L
F
I
M
D
E
A
D
K
M
L
-
S
-
R
-
D
F
K
T
I
-
I
E
Q
I
L
S
F
----
L
P
----
P
T
--
H
Q
S
L
L
F
S
A
T
F
P
L
T
V
----
K
E
F
M
V
K
H
L
H
K
P
Y
E
I
---
N
L
M
E
E
L
T
L
K
G
I
T
-
Q
-
Y
-
Y
A
F
V
E
ER
Q
-----
K
L
H
C
L
N
T
L
F
S
K
L
-
Q
I
N
Q
-
A
I
I
F
C
N
S
T
N
R
V
E
L
L
A
K
K
I
T
D
L
G
Y
S
C
Y
Y
S
H
A
R
M
K
Q
Q
E
R
N
K
V
F
H
E
F
R
Q
G
K
V
R
T
L
V
C
S
D
L
L
T
R
G
I
D
I
Q
A
V
N
V
V
I
N
F
D
F
P
K
------
T
A
------
E
T
Y
L
H
R
I
G
R
S
G
R
F
G
H
L
G
L
A
I
N
L
I
-
N
W
N
D
R
-
F
N
L
Y
K
I
E
Q
E
L
G
-----------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
82.56
33%
-135
- C4 -
2VSO
1
IF4A_YEAST
B:
[24-364]
-----------------
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
G
--
H
-
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
-------
D
-
T
------
S
------------------
V
---------
K
A
P
Q
---
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
----------------
A
L
A
F
H
M
D
I
K
V
H
A
C
I
G
----------
L
-
R
-
D
A
-
Q
I
V
V
G
T
P
G
R
V
F
D
-
N
I
Q
R
-
R
-
R
-
F
R
T
D
K
I
K
M
F
I
L
D
E
A
D
E
M
L
-
S
-
S
-
G
F
K
E
Q
-
I
Y
Q
I
F
T
L
----
L
P
----
P
T
--
T
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
E
L
T
L
--
E
G
I
K
Q
F
Y
V
-
N
-
V
-
E
E
E
----
E
Y----
K
Y
E
C
L
T
D
L
Y
D
S
I
-
S
V
T
Q
-
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
K
------
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
82.55
42%
-128
- C4 -
4KBG
4
?
B:
[3-324]
-----------------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
-------
A
P
S
------
Q
E
R
G
------------
R
-------------
K
P
R
---
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
------------------
T
A
V
A
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
-
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
-
G
-
V
-
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
-
M
-
G
F
E
E
E
-
V
E
A
L
L
S
A
----
T
P
----
P
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
-------
N
V
I
K
D
--
E
P
V
T
Y
-
E
-
E
-
E
A
V
----
P
APVRG
R
L
E
V
L
S
D
L
L
Y
V
A
-
S
P
D
R
-
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
------
R
A
------
E
A
Y
Q
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
PsiBlast_CBE
82.25
33%
-133
- C4 -
2VSX
1
IF4A_YEAST
B:
[24-364]
-----------------
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
G
--
H
-
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
-------
D
-
T
------
S
------------------
V
---------
K
A
P
Q
---
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
----------------
A
L
A
F
H
M
D
I
K
V
H
A
C
I
G
----------
L
-
R
-
D
A
-
Q
I
V
V
G
T
P
G
R
V
F
D
-
N
I
Q
R
-
R
-
R
-
F
R
T
D
K
I
K
M
F
I
L
D
E
A
D
E
M
L
-
S
-
S
-
G
F
K
E
Q
-
I
Y
Q
I
F
T
L
----
L
P
----
P
T
--
T
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
E
L
T
L
--
E
G
I
K
Q
F
Y
V
-
N
-
V
-
E
E
E
----
E
Y----
K
Y
E
C
L
T
D
L
Y
D
S
I
-
S
V
T
Q
-
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
K
------
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------
104
HHSearch
82.15
35%
-101
- C4 -
2DB3
3
VASA1_DROME
A:
[53-408]
------
Q
P
I
Q
------
H
F
T
S
A
D
L
R
D
I
I
I
D
N
V
N
K
S
G
Y
K
I
P
T
P
I
Q
K
C
S
I
P
V
I
S
S
G
--
R
-
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
K
L
-------
L
-
E
------
D
P
H
E
------------
L
-
E
L
---------
G
R
P
Q
---
V
V
I
V
S
P
T
R
E
L
A
I
Q
I
F
N
E
A
R
K
F
A
F
E
--
S
--------------
Y
L
K
I
G
I
V
Y
G
G
T
S
F
R
H
Q
N
E
C
I
-
T
R
G
C
-
H
V
V
I
A
T
P
G
R
L
L
D
-
F
V
D
R
-
T
-
F
-
I
T
F
E
D
T
R
F
V
V
L
D
E
A
D
R
M
L
-
D
-
M
-
G
F
S
E
D
-
M
R
R
I
M
T
H
----
V
T
MR--
P
E
--
H
Q
T
L
M
F
S
A
T
F
P
E
E
I
Q
R
M
A
G
E
F
L
K
N
Y
V
F
V
A
I
G
I
V
G
--
G
A
C
S
D
V
K
Q
T
I
Y
-
E
-
V
-
N
K
Y
----
A
-----
K
R
S
K
L
I
E
I
L
S
E
--
Q
A
D
G
-
T
I
V
F
V
E
T
K
R
G
A
D
F
L
A
S
F
L
S
E
K
E
F
P
T
T
S
I
H
G
D
R
L
Q
S
Q
R
E
Q
A
L
R
D
F
K
N
G
S
M
K
V
L
I
A
T
S
V
A
S
R
G
L
D
I
K
N
I
K
H
V
I
N
Y
D
M
P
S
------
K
I
------
D
D
Y
V
H
R
I
G
R
T
G
R
V
G
N
N
G
R
A
T
S
F
F
-
D
P
E
K
------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
82.14
42%
-125
- C4 -
4KBF
3
?
A:
[3-324]
-----------------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
-------
A
P
S
------
Q
E
R
G
------------
R
-------------
K
P
R
---
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
------------------
T
A
V
A
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
-
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
-
G
-
V
-
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
-
M
-
G
F
E
E
E
-
V
E
A
L
L
S
A
----
T
P
----
P
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
-------
N
V
I
K
D
--
E
P
V
T
Y
-
E
-
E
-
E
A
V
----
P
A
P
VRG
R
L
E
V
L
S
D
L
L
Y
V
A
-
S
P
D
R
-
A
M
V
F
T
R
T
K
A
E
T
E
E
I
A
Q
G
L
L
R
L
G
H
P
A
Q
A
L
H
G
D
L
S
Q
G
E
R
E
R
V
L
G
A
F
R
Q
G
E
V
R
V
L
V
A
T
D
V
A
A
R
G
L
D
I
P
Q
V
D
L
V
V
H
Y
R
L
P
D
------
R
A
------
E
A
Y
Q
H
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
81.53
33%
-132
- C4 -
2VSX
1
IF4A_YEAST
A:
[24-364]
-----------------
F
D
D
M
E
L
D
E
N
L
L
R
G
V
F
G
Y
G
F
E
E
P
S
A
I
Q
Q
R
A
I
M
P
I
I
E
G
--
H
-
D
V
L
A
Q
A
Q
S
G
T
G
K
T
G
T
F
S
I
A
A
L
Q
R
I
-------
D
-
T
------
S
------------------
V
---------
K
A
P
Q
---
A
L
M
L
A
P
T
R
E
L
A
L
Q
I
Q
K
V
V
M
----------------
A
L
A
F
H
M
D
I
K
V
H
A
C
I
G
----------
L
-
R
-
D
A
-
Q
I
V
V
G
T
P
G
R
V
F
D
-
N
I
Q
R
-
R
-
R
-
F
R
T
D
K
I
K
M
F
I
L
D
E
A
D
E
M
L
-
S
-
S
-
G
F
K
E
Q
-
I
Y
Q
I
F
T
L
----
L
P
----
P
T
--
T
Q
V
V
L
L
S
A
T
M
P
N
D
V
L
E
V
T
T
K
F
M
R
N
P
V
R
I
L
V
K
K
D
E
L
T
L
--
E
G
I
K
Q
F
Y
V
-
N
-
V
-
E
E
E
----
E
Y----
K
Y
E
C
L
T
D
L
Y
D
S
I
-
S
V
T
Q
-
A
V
I
F
C
N
T
R
R
K
V
E
E
L
T
T
K
L
R
N
D
K
F
T
V
S
A
I
Y
S
D
L
P
Q
Q
E
R
D
T
I
M
K
E
F
R
S
G
S
S
R
I
L
I
S
T
D
L
L
A
R
G
I
D
V
Q
Q
V
S
L
V
I
N
Y
D
L
P
A
------
N
K
------
E
N
Y
I
H
R
I
G
R
------
K
G
V
A
I
N
F
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
81.09
33%
-105
- C4 -
4D25
4
?
A:
[51-409]
----------------
S
F
E
T
A
N
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
G
--
R
-
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
M
L
L
Q
D
PKD
L
I
-
S
------
E
N
G
C
-------------------------
A
Q
P
Q
---
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
---
A
R
K
F
-------------
S
Y
G
S
V
L
K
V
A
V
A
Y
G
G
T
A
V
R
H
Q
G
D
N
I
-
A
R
G
C
-
H
I
L
V
A
T
P
G
R
L
H
D
-
F
V
E
R
-
N
-
R
-
V
S
F
G
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
-
D
-
M
-
G
F
M
P
S
-
I
E
K
M
M
L
H
PTMV
E
T
----
T
K
--
R
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
--
N
N
Y
L
F
V
A
V
G
I
V
G
G
A
S
T
D
V
E
Q
I
F
I
-
E
-
V
-
T
K
Y
----
E
-----
K
R
N
S
L
K
Q
L
I
E
E
N
-
D
G
K
R
-
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
------
S
I
------
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
-
D
S
D
Q
------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
80.38
37%
-120
- C4 -
2I4I
1
DDX3X_HUMAN
A:
[37-381]
-------------------------------------
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
K
--
R
-
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
-------
Y
-
S
DGP---
G
E
A
L
------------
R
A
M
K
E
NGRYGRR
K
Q
Y
P
I
---
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
---
A
R
K
F
-------------
S
Y
R
S
R
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
R
G
C
-
H
L
L
V
A
T
P
G
R
L
V
D
-
M
M
E
R
-
G
-
K
-
I
G
L
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
-
M
-
G
F
E
P
Q
-
I
R
R
I
V
E
Q
DT--
M
P
----
P
K
GV
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
-
A
V
G
----
T
S
E
N
I
T
Q
K
V
V
W
-
V
-
E
-
E
S
-----
D
-----
K
R
S
F
L
L
D
L
L
N
A
T
-
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
I
------
E
E
Y
V
H
R
I
G
R
T
G
R
--
N
L
G
L
A
T
S
F
F
-
N
---------------------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
80.26
33%
-105
- C4 -
4D26
4
?
A:
[51-409]
----------------
S
F
E
T
A
N
L
R
K
Y
V
L
D
N
V
L
K
A
G
Y
R
K
P
T
P
I
Q
K
N
A
I
P
I
I
M
S
G
--
R
-
D
L
M
G
C
A
Q
T
G
S
G
K
T
A
A
F
L
V
P
I
I
N
M
L
L
Q
D
P
K
D
L
I
-
S
------
E
N
G
C
-------------------------
A
Q
P
Q
---
V
I
I
V
S
P
T
R
E
L
T
L
Q
I
F
N
E
---
A
R
K
F
-------------
S
Y
G
S
V
L
K
V
A
V
A
Y
G
G
T
A
V
R
H
Q
G
D
N
I
-
A
R
G
C
-
H
I
L
V
A
T
P
G
R
L
H
D
-
F
V
E
R
-
N
-
R
-
V
S
F
G
S
V
R
F
V
V
L
D
Q
A
D
C
M
L
-
D
-
M
-
G
F
M
P
S
-
I
E
K
M
M
L
H
PTMV
E
T
----
T
K
--
R
Q
T
L
M
F
S
A
T
F
P
E
D
I
Q
H
L
A
G
R
F
L
--
N
N
Y
L
F
V
A
V
G
I
V
G
G
A
S
T
D
V
E
Q
I
F
I
-
E
-
V
-
T
K
Y
----
E
-----
K
R
N
S
L
K
Q
L
I
E
E
N
-
D
G
K
R
-
I
L
V
F
V
E
T
K
R
N
A
D
F
I
A
A
M
L
S
E
Q
Q
L
L
T
S
S
I
H
G
D
R
M
Q
R
E
R
E
E
A
L
Q
N
F
K
S
G
K
H
C
I
L
V
A
T
A
V
A
A
R
G
L
D
I
K
N
V
D
I
V
V
N
Y
D
L
P
K
------
S
I
------
D
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
R
G
K
A
V
S
F
Y
-
D
S
D
Q
------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
80.08
32%
-107
- C4 -
3FHT
4
DD19B_HUMAN
A:
[26-377]
----------------
S
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
E
P
P
Q
-
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
V
--------------------------------
E
P
A
N
---------
K
Y
P
Q
---
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
--
Y
---
P
E
L
K
L
A
Y
A
V
R
---------
G
N
K
L
E
R
G
Q
-----
K
I
S
E
-
Q
I
V
I
G
T
P
G
T
V
L
D
-
W
C
S
K
L
K
-
F
-
I
D
P
K
K
I
K
V
F
V
L
D
E
A
D
V
M
I
A
T
-
Q
-
G
H
Q
D
Q
-
S
I
R
I
Q
R
M
----
L
P
----
R
N
--
C
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
E
E
T
L
--
D
T
I
K
Q
Y
Y
V
-
L
-
C
-
S
S
R
----
D
E
----
K
F
Q
A
L
C
N
L
Y
G
A
I
-
T
I
A
Q
-
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
------
D
K
DGNPD
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
-
D
---------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
79.65
32%
-108
- C4 -
3FHT
6
DD19B_HUMAN
B:
[26-377]
----------------
S
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
E
P
P
Q
-
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
V
--------------------------------
E
P
A
N
---------
K
Y
P
Q
---
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
--
Y
---
P
E
L
K
L
A
Y
A
V
R
---------
G
N
-----------
K
I
S
E
-
Q
I
V
I
G
T
P
G
T
V
L
D
-
W
C
S
K
L
K
-
F
-
I
D
P
K
K
I
K
V
F
V
L
D
E
A
D
V
M
I
A
T
-
Q
-
G
H
Q
D
Q
-
S
I
R
I
Q
R
M
----
L
P
----
R
N
--
C
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
E
E
T
L
--
D
T
I
K
Q
Y
Y
V
-
L
-
C
-
S
S
R
----
D
E
----
K
F
Q
A
L
C
N
L
Y
G
A
I
-
T
I
A
Q
-
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
------
D
K
DGNPD
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
-
D
---------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
79.51
32%
-108
- C4 -
3G0H
4
DD19B_HUMAN
A:
[42-393]
----------------
S
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
E
P
P
Q
-
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
V
--------------------------------
E
P
A
N
---------
K
Y
P
Q
---
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
--
Y
---
P
E
L
K
L
A
Y
A
V
R
---------
G
N
K
L
E
R
G
Q
-----
K
I
S
E
-
Q
I
V
I
G
T
P
G
T
V
L
D
-
W
C
S
K
L
K
-
F
-
I
D
P
K
K
I
K
V
F
V
L
D
E
A
D
V
M
I
A
T
-
Q
-
G
H
Q
D
Q
-
S
I
R
I
Q
R
M
----
L
P
----
R
N
--
C
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
E
E
T
L
--
D
T
I
K
Q
Y
Y
V
-
L
-
C
-
S
S
R
----
D
E
----
K
F
Q
A
L
C
N
L
Y
G
A
I
-
T
I
A
Q
-
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
------
D
K
DGNPD
N
E
T
Y
L
H
R
I
G
R
T
G
R
F
G
K
R
G
L
A
V
N
M
V
-
D
---------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
79.45
32%
-114
- C4 -
3EWS
1
DD19B_HUMAN
A:
[63-414]
----------------
S
F
E
E
L
R
L
K
P
Q
L
L
Q
G
V
Y
A
M
G
F
N
R
P
S
K
I
Q
E
N
A
L
P
L
M
L
A
E
P
P
Q
-
N
L
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
V
L
A
M
L
S
Q
V
--------------------------------
E
P
A
N
---------
K
Y
P
Q
---
C
L
C
L
S
P
T
Y
E
L
A
L
Q
T
G
K
V
I
E
Q
M
G
K
F
--
Y
---
P
E
L
K
L
A
Y
A
V
R
---------
G
N
K
L
E
R
G
Q
-----
K
I
S
E
-
Q
I
V
I
G
T
P
G
T
V
L
D
-
W
C
S
K
L
K
-
F
-
I
D
P
K
K
I
K
V
F
V
L
D
E
A
D
V
M
I
A
T
-
Q
-
G
H
Q
D
Q
-
S
I
R
I
Q
R
M
----
L
P
----
R
N
--
C
Q
M
L
L
F
S
A
T
F
E
D
S
V
W
K
F
A
Q
K
V
V
P
D
P
N
V
I
K
L
K
R
E
E
E
T
L
--
D
T
I
K
Q
Y
Y
V
-
L
-
C
-
S
S
R
----
D
E
----
K
F
Q
A
L
C
N
L
Y
G
A
I
-
T
I
A
Q
-
A
M
I
F
C
H
T
R
K
T
A
S
W
L
A
A
E
L
S
K
E
G
H
Q
V
A
L
L
S
G
E
M
M
V
E
Q
R
A
A
V
I
E
R
F
R
E
G
K
E
K
V
L
V
T
T
N
V
C
A
R
G
I
D
V
E
Q
V
S
V
V
I
N
F
D
L
P
V
------
D
K
DGNPD
N
E
T
Y
L
H
R
I
G
R
----
G
K
R
G
L
A
V
N
M
V
-
D
---------------------------------------------------------------------------------------------------------------------------------------------------------
115
HHSearch
79.28
35%
-112
- C4 -
3PEY
11
DBP5_YEAST
A:
[4-360]
--------
A
K
------
S
F
D
E
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
N
P
P
R
-
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
V
-------
N
-
P
------
E
D
---------------------------
A
S
P
Q
---
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
F
--
T
--------------
K
I
T
S
Q
L
I
V
P
D
S
F
-
E
K
---
N
K
-
Q
I
N
A
-
Q
V
I
V
G
T
P
G
T
V
L
D
-
L
M
R
R
-
K
-
L
-
M
Q
L
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
-
D
-
Q
Q
G
L
G
D
Q
-
C
I
R
V
K
R
F
----
L
P
----
K
D
--
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
P
N
A
N
T
L
E
L
Q
T
N
E
--
V
N
V
D
A
I
K
Q
L
Y
M
D
C
-
K
-
N
E
A
----
D
-----
K
F
D
V
L
T
E
L
Y
G
L
M
-
T
I
G
S
-
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
LANGQA
D
P
------
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
-
H
D
K
N
S
-
F
N
--------------------------------------------------------------------------------------------------------------------------------------------------
106
HHSearch
79.13
31%
-122
- C4 -
1XTI
4
DX39B_HUMAN
A:
[9-358]
----------------
G
F
R
D
F
L
L
K
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
L
G
--
M
-
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
Q
Q
L
-------
E
-
P
------
V
T
---------------------------
G
Q
V
S
---
V
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
Y
E
R
F
S
K
Y
--
M
P
-------------
N
V
K
V
A
V
F
F
G
G
L
S
I
K
K
D
E
E
V
L
K
K
N
C
P
-
H
I
V
V
G
T
P
G
R
I
L
A
-
L
A
R
N
-
K
-
S
-
L
N
L
K
H
I
K
H
F
I
L
D
E
C
D
K
M
L
-
E
-
Q
L
D
M
R
R
D
-
V
Q
E
I
F
R
M
----
T
P
----
H
E
--
K
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
M
E
I
F
V
D
D
E
T
K
L
T
L
-
H
G
L
Q
Q
Y
Y
V
-
K
-
L
-
K
D
N
----
E
-----
K
N
R
K
L
F
D
L
L
D
V
L
-
E
F
N
Q
-
V
V
I
F
V
K
S
V
Q
R
C
I
A
L
A
Q
L
L
V
E
Q
N
F
P
A
I
A
I
H
R
G
M
P
Q
E
E
R
L
S
R
Y
Q
Q
F
K
D
F
Q
R
R
I
L
V
A
T
N
L
F
G
R
G
M
D
I
E
R
V
N
I
A
F
N
Y
D
M
P
E
------
D
S
------
D
T
Y
L
H
R
V
A
R
A
G
R
F
G
T
K
G
L
A
I
T
F
V
-
S
D
E
N
------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
79.02
37%
-111
- C4 -
5E7M
1
DDX3X_HUMAN
A:
[70-414]
-------------------------------------
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
K
--
R
-
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
-------
Y
-
S
D
GP---
G
E
A
L
------------
R
A
M
K
R
R
K
------
Q
Y
P
I
---
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
---
A
R
K
F
-------------
S
Y
R
S
R
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
R
G
C
-
H
L
L
V
A
T
P
G
R
L
V
D
-
M
M
E
R
-
G
-
K
-
I
G
L
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
-
M
-
G
F
E
P
Q
-
I
R
R
I
V
E
Q
DT--
M
P
----
P
K
GV
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
-
A
V
G
R
V
G
S
T
S
E
N
I
T
Q
K
V
V
W
-
V
-
E
-
E
S
-----
D
-----
K
R
S
F
L
L
D
L
L
N
A
T
-
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
I
------
E
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
F
F
-
N
---------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
78.48
32%
-106
- C4 -
5ELX
7
?
A:
[3-367]
----------------
S
F
D
E
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
N
P
P
R
-
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
V
-------
N
-
P
------
E
D
A
---------------------------
S
P
Q
---
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
F
TK
I
T
S
Q
L
I
V
P
D
S
F
E
K
N
K
Q
I
N
---------------------
A
-
Q
V
I
V
G
T
P
G
T
V
L
D
-
L
M
R
R
-
K
-
L
-
M
Q
L
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
-
D
-
Q
-
Q
G
L
G
D
Q
C
I
R
V
K
R
F
----
L
P
----
K
D
--
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
--
P
N
A
N
T
L
E
L
Q
T
N
E
V
N
V
D
A
I
K
Q
L
Y
M
-
D
-
C
K
N
E
A
----
D
-----
K
F
D
V
L
T
E
L
Y
G
L
M
-
T
I
G
S
-
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
LANGQA
D
P
------
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
N
S
F
-
N
I
L
S
A
I
Q
K
Y
F
G
-----------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
78.43
32%
-106
- C4 -
3PEY
11
DBP5_YEAST
A:
[6-370]
----------------
S
F
D
E
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
N
P
P
R
-
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
V
-------
N
-
P
------
E
D
A
S
---------------------------
P
Q
---
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
F
TK
I
T
S
Q
L
I
V
P
D
S
F
E
K
N
K
Q
I
N
---------------------
A
-
Q
V
I
V
G
T
P
G
T
V
L
D
-
L
M
R
R
-
K
-
L
-
M
Q
L
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
-
D
-
Q
-
Q
G
L
G
D
Q
C
I
R
V
K
R
F
----
L
P
----
K
D
--
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
--
P
N
A
N
T
L
E
L
Q
T
N
E
V
N
V
D
A
I
K
Q
L
Y
M
-
D
-
C
K
N
E
A
----
D
-----
K
F
D
V
L
T
E
L
Y
G
L
M
-
T
I
G
S
-
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
LANGQA
D
P
------
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
N
S
F
-
N
I
L
S
A
I
Q
K
Y
F
G
-----------------------------------------------------------------------------------------------------------------------------------------
32
PsiBlast_CBE
78.43
32%
-106
- C4 -
3PEW
9
DBP5_YEAST
A:
[6-370]
----------------
S
F
D
E
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
N
P
P
R
-
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
V
-------
N
-
P
------
E
D
A
S
---------------------------
P
Q
---
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
F
TK
I
T
S
Q
L
I
V
P
D
S
F
E
K
N
K
Q
I
N
---------------------
A
-
Q
V
I
V
G
T
P
G
T
V
L
D
-
L
M
R
R
-
K
-
L
-
M
Q
L
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
-
D
-
Q
-
Q
G
L
G
D
Q
C
I
R
V
K
R
F
----
L
P
----
K
D
--
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
--
P
N
A
N
T
L
E
L
Q
T
N
E
V
N
V
D
A
I
K
Q
L
Y
M
-
D
-
C
K
N
E
A
----
D
-----
K
F
D
V
L
T
E
L
Y
G
V
M
-
T
I
G
S
-
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
LANGQA
D
P
------
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
N
S
F
-
N
I
L
S
A
I
Q
K
Y
F
G
-----------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
78.11
37%
-108
- C4 -
5E7J
1
DDX3X_HUMAN
A:
[70-414]
-------------------------------------
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
K
--
R
-
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
-------
Y
-
S
D
GP---
G
E
A
L
------------
R
A
M
K
K--------
Q
Y
P
I
---
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
---
A
R
K
F
-------------
S
Y
R
S
R
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
R
G
C
-
H
L
L
V
A
T
P
G
R
L
V
D
-
M
M
E
R
-
G
-
K
-
I
G
L
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
-
M
-
G
F
E
P
Q
-
I
R
R
I
V
E
Q
DT--
M
P
----
P
K
GV
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
-
A
V
G
R
V
G
S
T
S
E
N
I
T
Q
K
V
V
W
-
V
-
E
-
E
S
-----
D
-----
K
R
S
F
L
L
D
L
L
N
A
T
-
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
I
------
E
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
F
F
-
N
---------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
76.56
37%
-103
- C4 -
4PXA
5
DDX3X_HUMAN
A:
[87-431]
-------------------------------------
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
K
--
R
-
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
-------
Y
-
S
DGP---
G
E
A
L
------------
R
A
M
K
E
NGRYGRR
K
Q
Y
P
I
---
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
---
A
R
K
F
-------------
S
Y
R
S
R
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
R
G
C
-
H
L
L
V
A
T
P
G
R
L
V
D
-
M
M
E
R
-
G
-
K
-
I
G
L
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
V
-
M
-
G
F
E
P
Q
-
I
R
R
I
V
E
Q
DT--
M
P
----
P
K
GV
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
D
E
Y
I
F
L
-
A
V
G
R
V
G
S
T
S
E
N
I
T
Q
K
V
V
W
-
V
-
E
-
E
S
-----
D
-----
K
R
S
F
L
L
D
L
L
N
A
T
-
G
K
D
S
L
T
L
V
F
V
E
T
K
K
G
A
D
S
L
E
D
F
L
Y
H
E
G
Y
A
C
T
S
I
H
G
D
R
S
Q
R
D
R
E
E
A
L
H
Q
F
R
S
G
K
S
P
I
L
V
A
T
A
V
A
A
R
G
L
D
I
S
N
V
K
H
V
I
N
F
D
L
P
S
------
D
I
------
E
E
Y
V
H
R
I
G
R
T
G
R
V
G
N
L
G
L
A
T
S
F
F
-
N
---------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
75.73
32%
-105
- C4 -
3RRN
2
DBP5_YEAST
A:
[6-370]
----------------
S
F
D
E
L
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
N
P
P
R
-
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
V
-------
N
-
P
------
E
D
A
S
---------------------------
P
Q
---
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
F
TK
I
T
S
Q
L
I
V
P
D
S
F
E
K
N
K
Q
I
N
---------------------
A
-
Q
V
I
V
G
T
P
G
T
V
L
D
-
L
M
R
R
-
K
-
L
-
M
Q
L
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
-
D
-
Q
-
Q
G
L
G
D
Q
C
I
R
V
K
R
F
----
L
P
----
K
D
--
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
--
P
N
A
N
T
L
E
L
Q
------
D
A
I
K
Q
L
Y
M
-
D
-
C
K
N
E
A
----
D
-----
K
F
D
V
L
T
E
L
Y
G
V
M
-
T
I
G
S
-
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
V
L
A
R
G
I
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
LANGQA
D
P
------
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
N
S
F
-
N
I
L
S
A
I
Q
K
Y
F
G
-----------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
74.77
32%
-108
- C4 -
3RRM
1
DBP5_YEAST
A:
[11-370]
---------------------
G
L
A
P
E
L
L
K
G
I
Y
A
M
K
F
Q
K
P
S
K
I
Q
E
R
A
L
P
L
L
L
H
N
P
P
R
-
N
M
I
A
Q
S
Q
S
G
T
G
K
T
A
A
F
S
L
T
M
L
T
R
V
-------
N
-
P
------
E
D
A
S
---------------------------
P
Q
---
A
I
C
L
A
P
S
R
E
L
A
R
Q
T
L
E
V
V
Q
E
M
G
K
F
TK
I
T
S
Q
L
I
V
P
D
S
F
E
K
N
K
Q
I
N
---------------------
A
-
Q
V
I
V
G
T
P
G
T
V
L
D
-
L
M
R
R
-
K
-
L
-
M
Q
L
Q
K
I
K
I
F
V
L
D
E
A
D
N
M
L
-
D
-
Q
-
Q
G
L
G
D
Q
C
I
R
V
K
R
F
----
L
P
----
K
D
--
T
Q
L
V
L
F
S
A
T
F
A
D
A
V
R
Q
Y
A
K
K
I
V
--
P
N
A
N
T
L
E
L
----
V
N
V
D
A
I
K
Q
L
Y
M
-
D
-
C
K
N
E
A
----
D
-----
K
F
D
V
L
T
E
L
Y
G
V
M
-
T
I
G
S
-
S
I
I
F
V
A
T
K
K
T
A
N
V
L
Y
G
K
L
K
S
E
G
H
E
V
S
I
L
H
G
D
L
Q
T
Q
E
R
D
R
L
I
D
D
F
R
E
G
R
S
K
V
L
I
T
T
N
------
D
I
P
T
V
S
M
V
V
N
Y
D
L
P
T
LANGQA
D
P
------
A
T
Y
I
H
R
I
G
R
T
G
R
F
G
R
K
G
V
A
I
S
F
V
H
D
K
N
S
F
-
N
I
L
S
A
I
Q
K
Y
F
G
-----------------------------------------------------------------------------------------------------------------------------------------
49
PsiBlast_CBE
71.38
46%
-136
- C4 -
2GXS
3
?
A:
[3-203]
-----------------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
-------
A
P
S
------
Q
E
R
G
------------
R
-------------
K
P
R
---
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
------------------
A
V
A
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
-
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
-
G
-
V
-
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
-
M
-
G
F
E
E
E
-
V
E
A
L
L
S
A
----
T
P
----
P
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
PsiBlast_CBE
70.75
45%
-142
- C4 -
3MWL
2
?
B:
[3-203]
-----------------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
-------
A
P
S
------
Q
E
R
G
------------
R
-------------
K
P
R
---
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
------------------
A
V
A
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
-
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
-
G
-
V
-
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
-
M
-
G
F
E
E
E
-
V
E
A
L
L
S
A
----
T
P
----
P
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
70.61
46%
-134
- C4 -
2GXS
4
?
B:
[3-203]
-----------------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
-------
A
P
S
------
Q
E
R
G
------------
R
-------------
K
P
R
---
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
------------------
A
V
A
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
-
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
-
G
-
V
-
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
-
M
-
G
F
E
E
E
-
V
E
A
L
L
S
A
----
T
P
----
P
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
70.49
46%
-138
- C4 -
2GXQ
2
?
A:
[3-203]
-----------------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
Q
A
A
A
L
P
L
A
L
E
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
-------
A
P
S
------
Q
E
R
G
------------
R
-------------
K
P
R
---
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
------------------
A
V
A
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
-
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
-
G
-
V
-
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
-
M
-
G
F
E
E
E
-
V
E
A
L
L
S
A
----
T
P
----
P
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
PsiBlast_CBE
70.33
45%
-136
- C4 -
3NBF
4
?
C:
[3-203]
-----------------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
-------
A
P
S
------
Q
E
R
G
------------
R
-------------
K
P
R
---
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
------------------
A
V
A
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
-
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
-
G
-
V
-
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
-
M
-
G
F
E
E
E
-
V
E
A
L
L
S
A
----
T
P
----
P
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
69.63
45%
-137
- C4 -
3MWK
2
?
B:
[3-203]
-----------------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
-------
A
P
S
------
Q
E
R
G
------------
R
-------------
K
P
R
---
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
------------------
A
V
A
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
-
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
-
G
-
V
-
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
-
M
-
G
F
E
E
E
-
V
E
A
L
L
S
A
----
T
P
----
P
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
69.44
45%
-131
- C4 -
3NBF
2
?
B:
[3-203]
-----------------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
-------
A
P
S
------
Q
E
R
G
------------
R
-------------
K
P
R
---
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
------------------
A
V
A
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
-
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
-
G
-
V
-
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
-
M
-
G
F
E
E
E
-
V
E
A
L
L
S
A
----
T
P
----
P
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
69.13
45%
-133
- C4 -
3NBF
2
?
A:
[3-203]
-----------------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
--
K
-
D
L
I
G
Q
A
R
T
G
T
G
K
T
L
A
F
A
L
P
I
A
E
R
L
-------
A
P
S
------
Q
E
R
G
------------
R
-------------
K
P
R
---
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
------------------
A
V
A
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
-
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
-
G
-
V
-
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
-
M
-
G
F
E
E
E
-
V
E
A
L
L
S
A
----
T
P
----
P
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
68.77
45%
-140
- C4 -
3NBF
2
?
D:
[3-203]
-----------------
F
K
D
F
P
L
K
P
E
I
L
E
A
L
H
G
R
G
L
T
T
P
T
P
I
E
A
A
A
L
P
L
A
L
E
G
--
K
-
D
L
I
G
Q
A
----
G
K
T
L
A
F
A
L
P
I
A
E
R
L
-------
A
P
S
------
Q
E
R
G
------------
R
-------------
K
P
R
---
A
L
V
L
T
P
T
R
E
L
A
L
Q
V
A
S
E
L
T
------------------
A
V
A
P
H
L
K
V
V
A
V
Y
G
G
T
G
Y
G
K
Q
K
E
A
L
-
L
R
G
A
-
D
A
V
V
A
T
P
G
R
A
L
D
-
Y
L
R
Q
-
G
-
V
-
L
D
L
S
R
V
E
V
A
V
L
D
E
A
D
E
M
L
-
S
-
M
-
G
F
E
E
E
-
V
E
A
L
L
S
A
----
T
P
----
P
S
--
R
Q
T
L
L
F
S
A
T
L
P
S
W
A
K
R
L
A
E
R
Y
M
K
N
P
V
L
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
67.68
37%
-132
- C4 -
3FE2
3
DDX5_HUMAN
A:
[30-235]
----------------
N
F
Y
E
A
N
F
P
A
N
V
M
D
V
I
A
R
Q
N
F
T
E
P
T
A
I
Q
A
Q
G
W
P
V
A
L
S
G
--
L
-
D
M
V
G
V
A
Q
T
G
S
G
K
T
L
S
Y
L
L
P
A
I
V
H
I
-------
N
-
H
Q
PFLER
G
D
G
----------------------------
P
I
---
C
L
V
L
A
P
T
R
E
L
A
Q
Q
V
Q
Q
---
V
A
A
E
Y
--
C
R
A
C
-----------
R
L
K
S
T
C
I
Y
G
G
A
P
K
G
P
Q
I
R
D
L
-
E
R
G
V
-
E
I
C
I
A
T
P
G
R
L
I
D
-
F
L
E
C
-
G
-
K
-
T
N
L
R
R
T
T
Y
L
V
L
D
E
A
D
R
M
L
-
D
-
M
-
G
F
E
P
Q
-
I
R
K
I
V
D
Q
----
I
R
----
P
D
--
R
Q
T
L
M
W
S
A
T
W
P
K
E
V
R
Q
L
A
E
D
F
L
K
D
Y
I
H
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
67.13
37%
-130
- C4 -
3FE2
4
DDX5_HUMAN
B:
[30-235]
----------------
N
F
Y
E
A
N
F
P
A
N
V
M
D
V
I
A
R
Q
N
F
T
E
P
T
A
I
Q
A
Q
G
W
P
V
A
L
S
G
--
L
-
D
M
V
G
V
A
Q
T
G
S
G
K
T
L
S
Y
L
L
P
A
I
V
H
I
-------
N
-
H
QPFLER
G
D
G
----------------------------
P
I
---
C
L
V
L
A
P
T
R
E
L
A
Q
Q
V
Q
Q
---
V
A
A
E
Y
--
C
R
A
C
-----------
R
L
K
S
T
C
I
Y
G
G
A
P
K
G
P
Q
I
R
D
L
-
E
R
G
V
-
E
I
C
I
A
T
P
G
R
L
I
D
-
F
L
E
C
-
G
-
K
-
T
N
L
R
R
T
T
Y
L
V
L
D
E
A
D
R
M
L
-
D
-
M
-
G
F
E
P
Q
-
I
R
K
I
V
D
Q
----
I
R
----
P
D
--
R
Q
T
L
M
W
S
A
T
W
P
K
E
V
R
Q
L
A
E
D
F
L
K
D
Y
I
H
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
67
PsiBlast_CBE
64.28
33%
-127
- C4 -
1T6N
1
DX39B_HUMAN
B:
[14-218]
---------
S
------
G
F
R
D
F
L
L
K
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
L
G
--
M
-
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
Q
Q
L
--------------------------------
E
P
V
T
---------
G
Q
V
S
---
V
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
Y
E
R
F
S
K
Y
--
M
---
P
N
----------
V
K
V
A
V
F
F
G
G
L
S
I
K
K
D
E
E
V
L
-
K
K
N
C
P
H
I
V
V
G
T
P
G
R
I
L
A
-
L
A
R
N
-
K
-
S
-
L
N
L
K
H
I
K
H
F
I
L
D
E
C
D
K
M
L
-
E
Q
L
-
D
M
R
R
D
-
V
Q
E
I
F
R
M
----
T
P
----
H
E
--
K
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
M
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
63.40
33%
-123
- C4 -
1T6N
1
DX39B_HUMAN
A:
[14-218]
---------
S
------
G
F
R
D
F
L
L
K
P
E
L
L
R
A
I
V
D
C
G
F
E
H
P
S
E
V
Q
H
E
C
I
P
Q
A
I
L
G
--
M
-
D
V
L
C
Q
A
K
S
G
M
G
K
T
A
V
F
V
L
A
T
L
Q
Q
L
--------------------------------
E
P
V
T
---------
G
Q
V
S
---
V
L
V
M
C
H
T
R
E
L
A
F
Q
I
S
K
E
Y
E
R
F
S
K
Y
--
M
---
P
N
----------
V
K
V
A
V
F
F
G
G
L
S
I
K
K
D
E
E
V
L
-
K
K
N
C
P
H
I
V
V
G
T
P
G
R
I
L
A
-
L
A
R
N
-
K
-
S
-
L
N
L
K
H
I
K
H
F
I
L
D
E
C
D
K
M
L
-
E
Q
L
-
D
M
R
R
D
-
V
Q
E
I
F
R
M
----
T
P
----
H
E
--
K
Q
V
M
M
F
S
A
T
L
S
K
E
I
R
P
V
C
R
K
F
M
Q
D
P
M
E
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
62.65
35%
-124
- C4 -
3BER
4
DDX47_HUMAN
A:
[37-242]
---
V
E
E
E
E
T
K
------
T
F
K
D
L
G
V
T
D
V
L
C
E
A
C
D
Q
L
G
W
T
K
P
T
K
I
Q
I
E
A
I
P
L
A
L
Q
G
--
R
-
D
I
I
G
L
A
E
T
G
S
G
K
T
G
A
F
A
L
P
I
L
-----------------------------------
N
A
L
L
---------
E
T
P
Q
R
LF
A
L
V
L
T
P
T
R
E
L
A
F
Q
I
S
E
Q
F
E
A
L
G
S
S
--
I
G
V
------
Q
S
A
V
--------
I
V
G
G
I
D
S
M
S
Q
S
L
A
L
-
A
K
K
P
-
H
I
I
I
A
T
P
G
R
L
I
D
-
H
L
E
N
-
T
-
K
G
F
N
L
R
A
L
K
Y
L
V
M
D
E
A
D
R
I
L
-
N
-
M
-
D
F
E
T
E
-
V
D
K
I
L
K
V
----
I
P
----
R
D
--
R
K
T
F
L
F
S
A
T
M
T
K
K
V
Q
K
L
Q
R
A
A
L
K
N
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
61.67
36%
-146
- C4 -
3IUY
2
DDX53_HUMAN
A:
[30-223]
-------------------------
D
L
L
K
S
I
I
R
V
G
I
L
K
P
T
P
I
Q
S
Q
A
W
P
I
I
L
Q
G
--
I
-
D
L
I
V
V
A
Q
T
G
T
G
K
T
L
S
Y
L
M
P
G
F
I
H
L
-------
D
-------------------------------------
N
G
P
G
---
M
L
V
L
T
P
T
R
E
L
A
L
H
V
E
---
A
E
C
S
K
Y
--
S
Y
K
G
------------
L
K
S
I
C
I
Y
G
------
Q
I
E
D
I
-
S
K
G
V
-
D
I
I
I
A
T
P
G
R
L
N
D
-
L
Q
M
N
-
N
-
S
-
V
N
L
R
S
I
T
Y
L
V
I
D
E
A
D
K
M
L
-
D
-
M
-
E
F
E
P
Q
-
I
R
K
I
L
L
D
----
V
R
----
P
D
--
R
Q
T
V
M
T
S
A
T
W
P
D
T
V
R
Q
L
A
L
S
Y
L
K
D
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
76
PsiBlast_CBE
60.77
33%
-117
- C4 -
2PL3
5
DDX10_HUMAN
A:
[27-230]
-----------------
F
S
D
F
P
L
S
K
K
T
L
K
G
L
Q
E
A
Q
Y
R
L
V
T
E
I
Q
K
Q
T
I
G
L
A
L
Q
G
--
K
-
D
V
L
G
A
A
K
T
G
S
G
K
T
L
A
F
L
V
P
V
L
E
A
L
-------
Y
-
R
------
L
Q
W
T
------------
S
--
T
---------
D
G
L
G
---
V
L
I
I
S
P
T
R
E
L
A
Y
Q
T
F
E
V
L
R
K
V
G
K
--------
N
H
D
F
S
A
G
L
--------
I
I
G
G
--
L
K
H
E
A
E
R
I
-
N
-
N
I
-
N
I
L
V
C
T
P
G
R
L
L
Q
H
M
D
E
T
-
V
-
S
-
F
H
A
T
D
L
Q
M
L
V
L
D
E
A
D
R
I
L
-
D
-
M
-
G
F
A
D
T
-
M
N
A
V
I
E
N
----
L
P
----
K
K
--
R
Q
T
L
L
F
S
A
T
Q
T
K
S
V
K
D
L
A
R
L
S
L
K
N
P
E
Y
V
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
60.18
36%
-141
- C4 -
3IUY
2
DDX53_HUMAN
B:
[30-223]
-------------------------
D
L
L
K
S
I
I
R
V
G
I
L
K
P
T
P
I
Q
S
Q
A
W
P
I
I
L
Q
G
--
I
-
D
L
I
V
V
A
Q
T
G
T
G
K
T
L
S
Y
L
M
P
G
F
I
H
L
-------
D
-
S
-----------------------------------
N
G
P
G
---
M
L
V
L
T
P
T
R
E
L
A
L
H
V
E
---
A
E
C
S
K
Y
--
S
Y
K
G
------------
L
K
S
I
C
I
Y
G
---------------
V
-
D
I
I
I
A
T
P
G
R
L
N
D
-
L
Q
M
N
-
N
-
S
-
V
N
L
R
S
I
T
Y
L
V
I
D
E
A
D
K
M
L
-
D
-
M
-
E
F
E
P
Q
-
I
R
K
I
L
L
D
----
V
R
----
P
D
--
R
Q
T
V
M
T
S
A
T
W
P
D
T
V
R
Q
L
A
L
S
Y
L
K
D
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
70
PsiBlast_CBE
59.73
37%
-118
- C4 -
4PX9
1
DDX3X_HUMAN
C:
[87-282]
-------------------------------------
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
K
--
R
-
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
-------
Y
-
S
DGP---
G
E
A
L
------------
R
A
M
K
ENGRYGRRK
Q
Y
P
I
---
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
---
A
R
K
F
-------------
S
Y
R
S
R
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
R
G
C
-
H
L
L
V
A
T
P
G
R
L
V
D
-
M
M
E
R
-
G
-
K
-
I
G
L
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
-
M
-
G
F
E
P
Q
-
I
R
R
I
V
E
Q
DT--
M
P
----
P
K
GV
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
72
PsiBlast_CBE
59.61
37%
-119
- C4 -
4PX9
1
DDX3X_HUMAN
A:
[87-282]
-------------------------------------
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
K
--
R
-
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
-------
Y
-
S
D
GP---
G
E
A
L
------------
R
A
M
K
ENGRYG
R
R
K
Q
Y
P
I
---
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
---
A
R
K
F
-------------
S
Y
R
S
R
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
R
G
C
-
H
L
L
V
A
T
P
G
R
L
V
D
-
M
M
E
R
-
G
-
K
-
I
G
L
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
-
M
-
G
F
E
P
Q
-
I
R
R
I
V
E
Q
DT--
M
P
----
P
K
GV
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
71
PsiBlast_CBE
59.59
37%
-118
- C4 -
4PX9
1
DDX3X_HUMAN
B:
[87-282]
-------------------------------------
R
P
T
P
V
Q
K
H
A
I
P
I
I
K
E
K
--
R
-
D
L
M
A
C
A
Q
T
G
S
G
K
T
A
A
F
L
L
P
I
L
S
Q
I
-------
Y
-
S
D
GP---
G
E
A
L
------------
R
A
M
K
ENGRYG
R
R
K
Q
Y
P
I
---
S
L
V
L
A
P
T
R
E
L
A
V
Q
I
Y
E
E
---
A
R
K
F
-------------
S
Y
R
S
R
V
R
P
C
V
V
Y
G
G
A
D
I
G
Q
Q
I
R
D
L
-
E
R
G
C
-
H
L
L
V
A
T
P
G
R
L
V
D
-
M
M
E
R
-
G
-
K
-
I
G
L
D
F
C
K
Y
L
V
L
D
E
A
D
R
M
L
-
D
-
M
-
G
F
E
P
Q
-
I
R
R
I
V
E
Q
DT--
M
P
----
P
K
GV
R
H
T
M
M
F
S
A
T
F
P
K
E
I
Q
M
L
A
R
D
F
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------