@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3224: (2016-05-17 )
MSLNGKTMFISGASRGIGLAIAKRAARDGANIALIAKTAEPHPKLPGTVFTAAKELEEAGGQALPIVGDIRDPDAVASAVATTVEQFGGIDICVNNASAINLGSITEVPMKRFDLMNGIQVRGTYAVSQACIPHMKGRENPHILTLSPPILLEKKWLRPTAYMMAKYGMTLCALGIAEEMRADGIASNTLWPRTMVATAAVQNLLGGDEAMARSRKPEVYADAAYVIVNKPATEYTGKTLLCEDVLVESGVTDLSVYDCVPGATLGVDLWVEDANPPGYLPA
Atome Classification :
(20 SA)
.........10....-....20........30........40...-----.....50......-..60.-........70........80........90........100-..---.......110.......120.......130......-.-140.......150..-.--...-..-160.......170.......180.......190...------------....200....-------.--------..210---.........-----220.......230.......240.......250.......260.......270.......280
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSLNG
K
T
M
F
I
SGASR-G
I
G
L
A
I
A
K
R
AARDGA
N
I
A
L
I
AKTAEPHPK-----LP
G
T
V
F
T
A
A
K
E
L
E
-
E
AG-G-QAL
P
I
VGDIR
D
P
D
A
V
A
S
A
V
A
T
T
V
E
Q
FG
G
I
D
I
C
VNNASAI---NL---G
S
I
T
EV
P
M
K
R
F
D
LMN
G
I
Q
V
R
G
T
Y
A
V
S
Q
A
CIPHMKGR-E-NP
H
I
L
TLSPP
I
-
L
L
E-K--KWL-R
P
-
T
A
Y
M
M
A
K
Y
G
M
T
L
C
A
L
G
I
A
E
E
M
RADGIASNTLW
P
R
T
M
------------
V
A
T
A
A
V
Q
N
L
LG-------
G
--------
D
E
A
-----
M
ARSRKP
E
V
-----YA
D
A
A
Y
V
I
V
NKPATEYTG
K
T
L
L
C
E
D
V
L
V
ESGVTD
L
S
V
YDCVPG
A
T
L
G
V
D
L
W
V
EDANPPGYLPA
1
PsiBlast_PDB
97.30
87%
-109
- C1 -
3SC4
10
?
A:
[6-282]
-
S
L
R
G
K
T
M
F
I
S
G
G
S
R
-
G
I
G
L
A
I
A
K
R
V
A
A
D
G
A
N
V
A
L
V
A
K
S
A
E
P
H
P
K
-----
L
P
G
T
I
Y
T
A
A
K
E
I
E
-
E
A
G
-
G
-
Q
A
L
P
I
V
G
D
I
R
D
G
D
A
V
A
A
A
V
A
K
T
V
E
Q
F
G
G
I
D
I
C
V
N
N
A
S
A
I
---
N
L
---
G
S
I
E
E
V
P
L
K
R
F
D
L
M
N
G
I
Q
V
R
G
T
Y
A
V
S
Q
S
C
I
P
H
M
K
G
R
-
D
-
N
P
H
I
L
T
L
S
P
P
I
-
R
L
E
-
P
--
K
W
L
-
R
P
-
T
P
Y
M
M
A
K
Y
G
M
T
L
C
A
L
G
I
A
E
E
L
R
D
A
G
I
A
S
N
T
L
W
P
R
T
T
------------
V
A
T
A
A
V
Q
N
L
L
G
-------
G
--------
D
E
A
-----
M
A
R
S
R
K
P
E
V
-----
Y
A
D
A
A
Y
V
V
L
N
K
P
S
S
-
Y
T
G
N
T
L
L
C
E
D
V
L
L
E
S
G
V
T
D
L
S
V
Y
D
C
V
P
G
S
E
L
G
V
D
L
W
V
D
S
P
N
P
P
G
Y
---
21
PsiBlast_CBE
96.16
87%
-110
- C1 -
3SC4
7
?
B:
[5-282]
M
S
L
R
G
K
T
M
F
I
S
G
G
S
R
-
G
I
G
L
A
I
A
K
R
V
A
A
D
G
A
N
V
A
L
V
A
K
S
A
E
P
H
P
K
-----
L
P
G
T
I
Y
T
A
A
K
E
I
E
-
E
A
G
-
G
-
Q
A
L
P
I
V
G
D
I
R
D
G
D
A
V
A
A
A
V
A
K
T
V
E
Q
F
G
G
I
D
I
C
V
N
N
A
S
A
I
---
N
L
---
G
S
I
E
E
V
P
L
K
R
F
D
L
M
N
G
I
Q
V
R
G
T
Y
A
V
S
Q
S
C
I
P
H
M
K
G
R
-
D
-
N
P
H
I
L
T
L
S
P
P
I
-
R
L
E
-
P
--
K
W
L
-
R
P
-
T
P
Y
M
M
A
K
Y
G
M
T
L
C
A
L
G
I
A
E
E
L
R
D
A
G
I
A
S
N
T
L
W
P
R
T
T
------------
V
A
T
A
A
V
Q
N
L
L
G
-------
G
--------
D
E
A
-----
M
A
R
S
R
K
P
E
V
-----
Y
A
D
A
A
Y
V
V
L
N
K
P
S
S
-
Y
T
G
N
T
L
L
C
E
D
V
L
L
E
S
G
V
T
D
L
S
V
Y
D
C
V
P
G
S
E
L
G
V
D
L
W
V
D
S
P
N
P
P
G
Y
---
60
HHSearch
91.86
84%
-103
- C1 -
3SC4
10
?
A:
[6-282]
-
S
L
R
G
K
T
M
F
I
S
G
G
S
R
-
G
I
G
L
A
I
A
K
R
V
A
A
D
G
A
N
V
A
L
V
A
K
S
A
E
P
H
P
K
-----
L
P
G
T
I
Y
T
A
A
K
E
I
E
-
E
A
G
-
G
-
Q
A
L
P
I
V
G
D
I
R
D
G
D
A
V
A
A
A
V
A
K
T
V
E
Q
F
G
G
I
D
I
C
V
N
N
A
S
A
I
---
N
L
---
G
S
I
E
E
V
P
L
K
R
F
D
L
M
N
G
I
Q
V
R
G
T
Y
A
V
S
Q
S
C
I
P
H
M
K
G
R
-
D
-
N
P
H
I
L
T
L
S
P
P
I
R
L
E
P
K
W
--
L
---
R
P
-
T
P
Y
M
M
A
K
Y
G
M
T
L
C
A
L
G
I
A
E
E
L
R
D
A
G
I
A
S
N
T
L
W
P
R
T
T
V
-----------
A
T
A
A
V
Q
N
L
L
G
G
----------------
D
E
A
-----
M
A
R
S
R
K
P
E
V
-----
Y
A
D
A
A
Y
V
V
L
N
K
P
S
-
S
Y
T
G
N
T
L
L
C
E
D
V
L
L
E
S
G
V
T
D
L
S
V
Y
D
C
V
P
G
S
E
L
G
V
D
L
W
V
D
S
P
N
P
P
G
Y
---
3
PsiBlast_PDB
80.19
50%
-103
- C1 -
3E03
1
?
A:
[2-273]
L
T
L
S
G
K
T
L
F
I
T
G
A
S
R
-
G
I
G
L
A
I
A
L
R
A
A
R
D
G
A
N
V
A
I
A
A
K
S
A
V
A
N
P
K
-----
L
P
G
T
I
H
S
A
A
A
A
V
N
-
A
A
G
-
G
-
Q
G
L
A
L
K
C
D
I
R
E
E
D
Q
V
R
A
A
V
A
A
T
V
D
T
F
G
G
I
D
I
L
V
N
N
A
S
A
I
---
W
L
---
R
G
T
L
D
T
P
M
K
R
F
D
L
M
Q
Q
V
N
A
R
G
S
F
V
C
A
Q
A
C
L
P
H
L
L
Q
A
-
P
-
N
P
H
I
L
T
L
A
P
P
P
-
S
L
N
-
P
--
A
W
W
G
A
H
-
T
G
Y
T
L
A
K
M
G
M
S
L
V
T
L
G
L
A
A
E
F
G
P
Q
G
V
A
I
N
A
L
W
P
R
T
V
------------
I
A
T
-------
G
-------
V
--------
D
A
A
-----
A
--
C
R
R
P
E
I
-----
M
A
D
A
A
H
A
V
L
T
R
E
A
A
G
F
H
G
Q
F
L
I
D
D
E
V
L
A
Q
A
G
I
T
D
L
S
G
Y
A
V
D
P
Q
R
A
L
L
P
D
L
F
L
E
E
---------
2
PsiBlast_PDB
79.59
48%
-107
- C1 -
3KVO
2
HSDL2_HUMAN
A:
[43-310]
--
L
A
G
C
T
V
F
I
T
G
A
S
R
-
G
I
G
K
A
I
A
L
K
A
A
K
D
G
A
N
I
V
I
A
A
K
T
A
Q
P
H
P
K
-----
L
L
G
T
I
Y
T
A
A
E
E
I
E
-
A
V
G
-
G
-
K
A
L
P
C
I
V
D
V
R
D
E
Q
Q
I
S
A
A
V
E
K
A
I
K
K
F
G
G
I
D
I
L
V
N
N
A
S
A
I
---
S
L
---
T
N
T
L
D
T
P
T
K
R
L
D
L
M
M
N
V
N
T
R
G
T
Y
L
A
S
K
A
C
I
P
Y
L
K
K
S
-
K
-
V
A
H
I
L
N
I
S
P
P
L
-
N
L
N
-
P
--
V
W
F
-
K
Q
H
C
A
Y
T
I
A
K
Y
G
M
S
M
Y
V
L
G
M
A
E
E
F
K
G
E
-
I
A
V
N
A
L
W
P
K
T
A
------------
I
H
T
A
A
M
-
D
M
L
G
-----------------
G
I
-----
E
S
Q
C
R
K
V
D
I
-----
I
A
D
A
A
Y
S
I
F
Q
K
P
K
S
-
F
T
G
N
F
V
I
D
E
N
I
L
K
E
E
G
I
E
N
F
D
V
Y
A
I
K
P
G
H
P
L
Q
P
D
F
F
L
D
----------
22
PsiBlast_CBE
79.43
48%
-105
- C1 -
3KVO
2
HSDL2_HUMAN
B:
[43-311]
--
L
A
G
C
T
V
F
I
T
G
A
S
R
-
G
I
G
K
A
I
A
L
K
A
A
K
D
G
A
N
I
V
I
A
A
K
T
A
Q
P
H
P
K
-----
L
L
G
T
I
Y
T
A
A
E
E
I
E
-
A
V
G
-
G
-
K
A
L
P
C
I
V
D
V
R
D
E
Q
Q
I
S
A
A
V
E
K
A
I
K
K
F
G
G
I
D
I
L
V
N
N
A
S
A
I
---
S
L
---
T
N
T
L
D
T
P
T
K
R
L
D
L
M
M
N
V
N
T
R
G
T
Y
L
A
S
K
A
C
I
P
Y
L
K
K
S
-
K
-
V
A
H
I
L
N
I
S
P
P
L
-
N
L
N
-
P
--
V
W
F
-
K
Q
H
C
A
Y
T
I
A
K
Y
G
M
S
M
Y
V
L
G
M
A
E
E
F
K
G
E
-
I
A
V
N
A
L
W
P
K
T
A
------------
I
H
T
A
A
M
-
D
M
L
G
-------
G
--------
P
G
I
-----
E
S
Q
C
R
K
V
D
I
-----
I
A
D
A
A
Y
S
I
F
Q
K
P
K
S
-
F
T
G
N
F
V
I
D
E
N
I
L
K
E
E
G
I
E
N
F
D
V
Y
A
I
K
P
G
H
P
L
Q
P
D
F
F
L
D
E
---------
12
PsiBlast_PDB
64.78
28%
-104
- C1 -
2CFC
2
HCDR_XANP2
A:
[3-244]
-----
R
V
A
I
V
T
G
A
S
S
-
G
N
G
L
A
I
A
T
R
F
L
A
R
G
D
R
V
A
A
L
D
L
S
A
E
T
L
E
E
-----------
T
A
R
T
H
W
H
-
A
Y
A
-
D
-
K
V
L
R
V
R
A
D
V
A
D
E
G
D
V
N
A
A
I
A
A
T
M
E
Q
F
G
A
I
D
V
L
V
N
N
A
G
I
T
GNS
E
A
---
G
V
L
H
T
T
P
V
E
Q
F
D
K
V
M
A
V
N
V
R
G
I
F
L
G
C
R
A
V
L
P
H
M
L
L
Q
-
G
-
A
G
V
I
V
N
I
A
S
V
A
-
S
L
V
-
A
--
F
P
G
-
R
--
S
A
Y
T
T
S
K
G
A
V
L
Q
L
T
K
S
V
A
V
D
Y
A
G
S
G
I
R
C
N
A
V
C
P
-
G
M
------------
I
E
T
P
M
T
Q
W
R
L
D
-------
Q
P
E
L
R
----
D
Q
V
-----
L
A
R
I
P
Q
K
E
I
G
T
A
A
Q
V
A
D
A
V
M
F
L
A
G
E
D
A
T
Y
V
N
G
A
A
L
V
M
D
---------------------------------------
16
PsiBlast_PDB
61.38
25%
-93
- C1 -
3AUT
-
DHG4_BACME
A:
[13-255]
--
L
K
D
K
V
V
V
I
T
G
G
S
T
-
G
L
G
R
A
M
A
V
R
F
G
Q
E
E
A
K
V
V
I
N
Y
Y
N
N
E
E
E
-----------
A
L
D
A
K
K
E
V
E
-
E
A
G
-
G
-
Q
A
I
I
V
Q
G
D
V
T
K
E
E
D
V
V
N
L
V
Q
T
A
I
K
E
F
G
T
L
D
V
M
I
N
N
A
G
V
E
---
N
P
---
V
P
S
H
E
L
S
L
D
N
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I
K
G
N
V
I
N
M
S
-
S
V
-
H
E
M
-
I
--
P
W
P
-
L
F
-
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
M
NTPIN
A
E
K
F
A
D
P
V
Q
R
A
D
V
E
S
M
I
-------------------
P
-----
M
G
Y
I
G
K
P
E
E
-----
V
A
A
V
A
A
F
L
A
S
S
Q
A
S
Y
V
T
G
I
T
L
F
A
D
---------------------------------------
15
PsiBlast_PDB
61.28
25%
-94
- C1 -
3AUS
-
DHG4_BACME
A:
[5-247]
--
L
K
D
K
V
V
V
I
T
G
G
S
T
-
G
L
G
R
A
M
A
V
R
F
G
Q
E
E
A
K
V
V
I
N
Y
Y
N
N
E
E
E
-----------
A
L
D
A
K
K
E
V
E
-
E
A
G
-
G
-
Q
A
I
I
V
Q
G
D
V
T
K
E
E
D
V
V
N
L
V
Q
T
A
I
K
E
F
G
T
L
D
V
M
I
N
N
A
G
V
E
---
N
P
---
V
P
S
H
E
L
S
L
D
N
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I
K
G
N
V
I
N
M
S
-
S
V
-
H
E
M
-
I
--
P
W
P
-
L
F
-
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
M
NTPIN
A
E
K
F
A
D
P
V
Q
R
A
D
V
E
S
M
I
-------------------
P
-----
M
G
Y
I
G
K
P
E
E
-----
V
A
A
V
A
A
F
L
A
S
S
Q
A
S
Y
V
T
G
I
T
L
F
A
D
---------------------------------------
18
PsiBlast_PDB
61.18
25%
-92
- C1 -
3AY7
-
DHG4_BACME
A:
[13-255]
--
L
K
D
K
V
V
V
I
T
G
G
S
T
-
G
L
G
R
A
M
A
V
R
F
G
Q
E
E
A
K
V
V
I
N
Y
Y
N
N
E
E
E
-----------
A
L
D
A
K
K
E
V
E
-
E
A
G
-
G
-
Q
A
I
I
V
Q
G
D
V
T
K
E
E
D
V
V
N
L
V
Q
T
A
I
K
E
F
G
T
L
D
V
M
I
N
N
A
G
V
E
---
N
P
---
V
P
S
H
E
L
S
L
D
N
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I
K
G
N
V
I
N
M
S
-
S
V
-
H
E
M
-
I
--
P
W
P
-
L
F
-
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
M
NTPIN
A
E
K
F
A
D
P
V
Q
R
A
D
V
E
S
M
I
-------------------
P
-----
M
G
Y
I
G
K
P
E
E
-----
V
A
A
V
A
A
F
L
A
S
S
Q
A
S
Y
V
T
G
I
T
L
F
A
D
---------------------------------------
17
PsiBlast_PDB
60.64
25%
-93
- C1 -
3AUU
1
DHG4_BACME
A:
[13-255]
--
L
K
D
K
V
V
V
I
T
G
G
S
T
-
G
L
G
R
A
M
A
V
R
F
G
Q
E
E
A
K
V
V
I
N
Y
Y
N
N
E
E
E
-----------
A
L
D
A
K
K
E
V
E
-
E
A
G
-
G
-
Q
A
I
I
V
Q
G
D
V
T
K
E
E
D
V
V
N
L
V
Q
T
A
I
K
E
F
G
T
L
D
V
M
I
N
N
A
G
V
E
---
N
P
---
V
P
S
H
E
L
S
L
D
N
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I
K
G
N
V
I
N
M
S
-
S
V
-
H
E
M
-
I
--
P
W
P
-
L
F
-
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
M
NTPINAEKFAD
P
V
Q
R
A
D
V
E
S
M
I
-------------------
P
-----
M
G
Y
I
G
K
P
E
E
-----
V
A
A
V
A
A
F
L
A
S
S
Q
A
S
Y
V
T
G
I
T
L
F
A
D
---------------------------------------
14
PsiBlast_PDB
60.31
25%
-93
- C1 -
3AY6
2
DHG4_BACME
A:
[13-255]
--
L
K
D
K
V
V
V
I
T
G
G
S
T
-
G
L
G
R
A
M
A
V
R
F
G
Q
E
E
A
K
V
V
I
N
Y
Y
N
N
E
E
E
-----------
A
L
D
A
K
K
E
V
E
-
E
A
G
-
G
-
Q
A
I
I
V
Q
G
D
V
T
K
E
E
D
V
V
N
L
V
Q
T
A
I
K
E
F
G
T
L
D
V
M
I
N
N
A
G
V
E
---
N
P
---
V
P
S
H
E
L
S
L
D
N
W
N
K
V
I
D
T
N
L
T
G
A
F
L
G
S
R
E
A
I
K
Y
F
V
E
N
-
D
I
K
G
N
V
I
N
M
S
-
S
V
-
H
E
M
-
I
--
P
W
P
-
L
F
-
V
H
Y
A
A
S
K
G
G
M
K
L
M
T
E
T
L
A
L
E
Y
A
P
K
G
I
R
V
N
N
I
G
P
G
A
M
NTPIN
A
E
K
F
A
D
P
V
Q
R
A
D
V
E
S
M
I
-------------------
P
-----
M
G
Y
I
G
K
P
E
E
-----
V
A
A
V
A
A
F
L
A
S
S
Q
A
S
Y
V
T
G
I
T
L
F
A
D
---------------------------------------
66
HHSearch
59.80
24%
-89
- C1 -
3GAF
-
?
A:
[8-249]
-
H
L
N
D
A
V
A
I
V
T
G
A
A
A
-
G
I
G
R
A
I
A
G
T
F
A
K
A
G
A
S
V
V
V
T
D
L
K
S
E
------------
G
A
E
A
V
A
A
A
I
R
-
Q
A
G
-
G
-
K
A
I
G
L
E
C
N
V
T
D
E
Q
H
R
E
A
V
I
K
A
A
L
D
Q
F
G
K
I
T
V
L
V
N
N
A
G
G
G
---
G
P
---
K
P
F
-
D
M
P
M
S
D
F
E
W
A
F
K
L
N
L
F
S
L
F
R
L
S
Q
L
A
A
P
H
M
Q
K
A
-
G
-
G
G
A
I
L
N
I
S
S
M
A
G
E
N
T
-
N
--
V
---
R
M
-
A
S
Y
G
S
S
K
A
A
V
N
H
L
T
R
N
I
A
F
D
V
G
P
M
G
I
R
V
N
A
I
A
P
G
A
I
------------
K
T
D
A
L
A
T
V
L
T
P
-------
E
I
E
R
A
M
L
K
-
H
T
P
-----
L
G
R
L
G
E
A
Q
D
-----
I
A
N
A
A
L
F
L
C
S
P
A
A
A
W
I
S
G
Q
V
L
T
V
S
G
G
-------------------------------------
54
HHSearch
58.67
25%
-80
- C1 -
4RGB
1
?
A:
[21-290]
G
S
L
D
G
R
V
V
F
I
T
G
A
A
R
-
G
Q
G
R
S
H
A
V
M
C
A
E
Q
G
A
N
I
V
G
V
D
I
C
E
D
I
D
I
V
PYKLG
T
Y
E
E
L
E
E
T
A
R
L
V
E
-
K
T
G
-
Q
-
E
M
L
F
R
K
A
D
V
R
D
K
A
V
L
Q
E
V
F
D
A
G
V
E
Q
F
G
H
I
D
T
V
I
A
N
A
G
V
V
---
L
T
---
N
P
D
E
R
D
A
S
E
A
L
R
L
G
L
D
I
M
L
I
G
V
W
N
T
F
Q
V
A
I
P
H
M
K
E
R
-
G
Q
G
G
N
L
I
A
T
S
S
M
I
A
L
L
D
-
L
TD
G
R
G
-
G
T
-
D
A
Y
L
T
S
K
L
A
I
T
G
L
V
R
S
Y
A
L
M
L
A
A
D
R
I
R
V
N
G
V
A
P
T
N
C
------------
S
T
P
M
I
T
E
N
P
A
L
F
K
V
I
E
E
N
P
HLVNAMST
A
L
P
-----
D
F
P
M
I
E
P
R
D
-----
V
S
N
A
I
L
F
L
I
S
D
A
G
R
S
F
T
G
S
V
L
K
V
D
A
G
M
------------------------------------
67
HHSearch
57.51
26%
-86
- C1 -
4J2H
6
?
A:
[9-252]
-
D
L
S
G
R
R
A
L
V
T
G
A
S
R
-
G
I
G
Q
S
I
A
V
A
L
A
E
A
G
A
H
V
A
V
T
A
R
T
V
E
------------
G
L
A
E
T
R
A
L
I
E
-
K
T
G
-
R
-
R
A
V
A
L
A
Q
D
V
R
D
V
E
A
C
A
S
V
T
R
A
A
A
E
G
L
G
G
L
D
I
L
V
N
N
A
G
F
E
---
N
V
---
R
P
S
F
D
V
D
E
A
L
W
D
T
I
V
S
T
N
L
K
G
A
F
F
C
A
Q
A
A
G
R
I
M
A
D
A
-
N
-
G
G
A
I
V
N
L
C
S
L
T
S
Y
V
G
-
I
--
P
---
T
A
-
V
P
Y
G
A
S
K
S
G
L
L
G
V
T
R
A
L
A
T
E
W
A
A
H
N
I
R
V
N
A
I
A
P
G
Y
F
------------
R
T
A
M
T
A
G
F
Y
E
D
-------
E
D
W
Q
S
R
M
L
E
K
I
P
-----
Q
R
R
F
G
K
E
S
D
-----
I
G
G
V
A
V
F
L
C
S
D
A
A
A
Y
I
T
G
H
C
I
P
A
D
G
G
-------------------------------------
6
PsiBlast_PDB
56.48
28%
-95
- C1 -
3AI1
-
?
A:
[3-187]
M
G
I
S
G
K
V
A
V
I
T
G
S
S
S
-
G
I
G
L
A
I
A
E
G
F
A
K
E
G
A
H
I
V
L
V
A
R
Q
V
D
------------
R
L
H
E
A
A
R
S
L
K
-
E
K
F
-
G
V
R
V
L
E
V
A
V
D
V
A
T
P
E
G
V
D
A
V
V
E
S
V
R
S
S
F
G
G
A
D
I
L
V
N
N
A
G
T
G
---
S
N
---
E
T
I
M
E
A
A
D
E
K
W
Q
F
Y
W
E
L
H
V
M
A
A
V
R
L
A
R
G
L
V
P
G
M
R
A
R
-
G
-
G
G
A
I
I
H
N
A
S
I
C
-
A
V
Q
-
P
--
L
W
Y
-
E
P
-
I
-
Y
N
V
T
K
A
A
L
M
M
F
S
K
T
L
A
T
E
V
I
K
D
N
I
R
V
N
C
I
N
P
-------------------------------------------------------------------------------------------------------------------------------
63
HHSearch
56.28
21%
-87
- C1 -
3O38
-
?
A:
[19-263]
-
L
L
K
G
K
V
V
L
V
T
A
A
A
G
T
G
I
G
S
T
T
A
R
R
A
L
L
E
G
A
D
V
V
I
S
D
Y
H
E
R
------------
R
L
G
E
T
R
D
Q
L
A
-
D
L
G
L
G
-
R
V
E
A
V
V
C
D
V
T
S
T
E
A
V
D
A
L
I
T
Q
T
V
E
K
A
G
R
L
D
V
L
V
N
N
A
G
L
G
---
G
Q
---
T
P
V
V
D
M
T
D
E
E
W
D
R
V
L
N
V
T
L
T
S
V
M
R
A
T
R
A
A
L
R
Y
F
R
G
V
D
H
-
G
G
V
I
V
N
N
A
S
V
L
G
W
R
A
-
Q
--
H
---
S
Q
-
S
H
Y
A
A
A
K
A
G
V
M
A
L
T
R
C
S
A
I
E
A
V
E
F
G
V
R
I
N
A
V
S
P
S
I
A
------------
R
H
-------------------------
D
E
A
-----
F
G
R
A
A
E
P
W
E
-----
V
A
A
T
I
A
F
L
A
S
D
Y
S
S
Y
M
T
G
E
V
V
S
V
S
S
--------------------------------------
70
HHSearch
56.26
27%
-89
- C1 -
2CFC
2
HCDR_XANP2
A:
[1-246]
---
M
S
R
V
A
I
V
T
G
A
S
S
-
G
N
G
L
A
I
A
T
R
F
L
A
R
G
D
R
V
A
A
L
D
L
S
A
E
------------
T
L
E
E
T
A
R
T
H
W
H
A
Y
A
-
D
-
K
V
L
R
V
R
A
D
V
A
D
E
G
D
V
N
A
A
I
A
A
T
M
E
Q
F
G
A
I
D
V
L
V
N
N
A
G
I
T
---
G
N
SEA
G
V
L
H
T
T
P
V
E
Q
F
D
K
V
M
A
V
N
V
R
G
I
F
L
G
C
R
A
V
L
P
H
M
L
L
Q
-
G
-
A
G
V
I
V
N
I
A
S
V
A
S
L
V
A
-
F
--
P
---
G
R
-
S
A
Y
T
T
S
K
G
A
V
L
Q
L
T
K
S
V
A
V
D
Y
A
G
S
G
I
R
C
N
A
V
C
P
G
M
I
------------
E
T
P
M
T
Q
W
R
L
D
Q
-------
P
E
L
R
D
Q
V
L
A
R
I
P
-----
Q
K
E
I
G
T
A
A
Q
-----
V
A
D
A
V
M
F
L
A
G
E
D
A
T
Y
V
N
G
A
A
L
V
M
D
G
A
-------------------------------------
11
PsiBlast_PDB
56.25
25%
-81
- C1 -
3WOH
-
?
A:
[6-244]
-
A
L
S
G
K
V
A
L
V
T
G
G
S
R
-
G
L
G
R
A
M
A
L
R
L
A
R
D
G
A
A
V
A
I
V
Y
V
S
D
D
S
S
A
K
-----------
E
T
Q
G
E
I
E
-
R
L
G
-
G
-
T
A
R
S
Y
R
C
D
V
S
D
A
E
Q
V
T
R
C
V
K
A
V
T
A
D
L
G
P
V
D
I
L
V
N
N
A
G
I
I
---
R
D
---
G
L
A
A
S
I
K
D
E
D
Y
D
A
V
M
N
T
N
L
K
G
A
F
L
F
I
K
A
C
Y
F
G
F
I
R
K
-
R
-
S
G
S
I
I
N
I
S
S
V
S
-
G
V
F
-
G
--
S
A
G
-
Q
A
-
N
-
Y
A
S
A
K
A
G
L
I
G
L
T
K
S
I
A
K
E
L
A
E
R
N
V
R
C
N
A
V
A
P
-
G
L
------------
I
A
T
D
-------------------------
R
LDPVP
M
R
R
F
G
R
P
D
E
-----
V
A
G
L
V
A
F
L
A
G
D
E
S
S
Y
I
T
G
Q
-
V
V
C
V
D
--------------------------------------
73
HHSearch
55.82
25%
-99
- C1 -
4NI5
-
?
A:
[10-249]
-
R
F
K
D
K
V
V
I
V
T
G
G
A
S
-
G
I
G
E
A
T
A
R
A
F
I
R
E
G
A
K
V
V
I
A
D
F
S
D
-------------------------------
A
L
F
I
K
T
D
V
A
D
T
R
A
V
Q
A
L
I
A
R
T
V
E
N
Y
G
R
L
D
I
M
F
A
N
A
G
I
A
---
A
D
---
A
P
I
D
E
L
D
E
A
A
W
Q
K
T
I
D
I
N
L
T
G
V
Y
L
C
D
K
Y
A
I
D
Q
M
R
S
Q
-
G
-
G
G
V
I
V
N
C
G
S
I
H
S
H
V
G
-
K
--
S
---
G
V
-
T
A
Y
A
A
A
K
G
G
V
K
L
L
T
Q
T
L
A
I
D
Y
G
P
Q
N
I
R
V
N
A
V
C
P
G
Y
I
------------
D
T
------
P
D
D
-------
K
K
Q
A
L
V
A
--
L
H
P
-----
M
G
R
L
G
R
A
E
E
-----
V
A
N
A
V
L
F
L
A
S
D
E
A
S
F
V
N
G
A
S
L
L
V
D
G
--------------------------------------