@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3274c: (2016-05-18 )
MVGWAGNPSFDLFKLPEEHDEMRSAIRALAEKEIAPHAAEVDEKARFPEEALVALNSSGFNAVHIPEEYGGQGADSVATCIVIEEVARVDASASLIPAVNKLGTMGLILRGSEELKKQVLPALAAEGAMASYALSEREAGSDAASMRTRAKADGDHWILNGAKCWITNGGKSTWYTVMAVTDPDRGANGISAFMVHKDDEGFTVGPKERKLGIKGSPTTELYFENCRIPGDRIIGEPGTGFKTALATLDHTRPTIGAQAVGIAQGALDAAIAYTKDRKQFGESISTFQAVQFMLADMAMKVEAARLMVYSAAARAERGEPDLGFISAASKCFASDVAMEVTTDAVQLFGGAGYTTDFPVERFMRDAKITQIYEGTNQIQRVVMSRALLR
Atome Classification :
(34 SA)
---------.........10.....--------...20........30........40...-.....50........60........70...---..---...80........90.-...-..-..100-........110........120.......130.......140.......150--....-....160.......170.......180..----...---..-----190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320-----------.........--330.......340.......350.......360.......370.......380.......-------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
---------MVGWAGNPSFDLFKL
P
--------
E
E
H
D
E
M
R
S
A
I
R
A
L
A
E
K
EIAP
H
A
A
E
V
D
E
K
-ARF
P
E
E
A
L
V
A
LNSSGF
N
A
V
HI
P
E
E
YGGQ
G
A
---
D
S
---
V
A
T
C
I
V
I
E
E
V
A
RVDA
S
-
A
S
L
-
I
P
-
A
V
N
-K-LGT
M
G
L
I
LR-
G
S
E
E
L
K
K
Q
V
L
P
A
L
A
AEG
A
M
A
S
YALSEREAGS
D
A
A
S
M
RTRA-K--ADGD-
H
W
I
LNG
A
K
C
W
I
TNGGK
S
T
W
Y
T
V
M
A
V
TDPD----RGA---NG-----
I
S
A
F
M
V
HKDDEG
F
T
VG
P
K
E
RKLGIKGSPT
T
E
L
Y
F
ENCRIPGDRIIGEPGT
G
F
K
T
A
L
A
T
LDHTRPTIG
A
Q
A
V
G
I
A
Q
G
A
L
D
A
A
I
A
Y
T
K
D
R
K
Q
F
G
E
S
I
S
T
F
Q
A
V
Q
F
M
L
A
D
M
A
M
K
V
E
A
A
R
L
M
V
Y
S
AAARAERGEP-------------D
L
G
F
I
S
A
A
S
--
K
C
F
AS
D
V
A
M
E
V
T
T
D
A
V
Q
L
FGGAGYTTDF
P
V
E
R
F
M
R
DA
K
I
T
Q
I
Y
E
G
T
N
Q
I
Q
R
V
V
M
S
R
A
LLR-------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
98.46
91%
-76
- C1 -
3PFD
8
?
D:
[22-393]
----------------------------------
E
H
I
A
L
R
E
A
I
R
A
L
A
E
K
E
I
A
P
Y
A
A
E
V
D
E
K
-
A
R
F
P
E
E
A
L
A
A
L
N
S
S
G
F
S
A
I
H
V
P
E
E
Y
G
G
Q
G
A
---
D
S
---
V
A
T
C
I
V
I
E
E
V
A
R
V
D
C
S
-
A
S
L
-
I
P
-
A
V
N
-
K
-
L
G
T
M
G
L
I
L
R
-
G
S
E
E
L
K
K
Q
V
L
P
A
V
A
S
G
E
A
M
A
S
Y
A
L
S
E
R
E
A
G
S
D
A
A
S
M
R
T
R
A
-
V
--
A
D
G
D
-
D
W
I
L
N
G
S
K
C
W
I
T
N
G
G
K
S
T
W
Y
T
V
M
A
V
T
D
P
D
----
K
G
A
---
N
G
-----
I
S
A
F
M
V
H
K
D
D
E
G
F
T
V
G
P
K
E
R
K
L
G
I
K
G
S
P
T
T
E
L
Y
F
E
N
C
R
I
P
G
D
R
I
I
G
E
P
G
T
G
F
K
T
A
L
A
T
L
D
H
T
R
P
T
I
G
A
Q
A
V
G
I
A
Q
G
A
L
D
A
A
I
A
Y
T
K
E
R
K
Q
F
G
R
P
V
S
D
N
Q
G
V
Q
F
M
L
A
D
M
A
M
K
I
E
A
A
R
L
M
V
Y
S
A
A
A
R
A
E
R
G
----------------
L
G
F
I
S
A
A
S
--
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
L
F
G
G
Y
G
Y
T
Q
D
F
P
V
E
R
M
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
Q
I
Q
R
V
V
M
S
R
A
L
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
98.06
91%
-75
- C1 -
3PFD
1
?
B:
[22-393]
----------------------------------
E
H
I
A
L
R
E
A
I
R
A
L
A
E
K
E
I
A
P
Y
A
A
E
V
D
E
K
-
A
R
F
P
E
E
A
L
A
A
L
N
S
S
G
F
S
A
I
H
V
P
E
E
Y
G
G
Q
G
A
---
D
S
---
V
A
T
C
I
V
I
E
E
V
A
R
V
D
C
S
-
A
S
L
-
I
P
-
A
V
N
-
K
-
L
G
T
M
G
L
I
L
R
-
G
S
E
E
L
K
K
Q
V
L
P
A
V
A
S
G
E
A
M
A
S
Y
A
L
S
E
R
E
A
G
S
D
A
A
S
M
R
T
R
A
-
V
--
A
D
G
D
-
D
W
I
L
N
G
S
K
C
W
I
T
N
G
G
K
S
T
W
Y
T
V
M
A
V
T
D
P
D
----
K
G
A
---
N
G
-----
I
S
A
F
M
V
H
K
D
D
E
G
F
T
V
G
P
K
E
R
K
L
G
I
K
G
S
P
T
T
E
L
Y
F
E
N
C
R
I
P
G
D
R
I
I
G
E
P
G
T
G
F
K
T
A
L
A
T
L
D
H
T
R
P
T
I
G
A
Q
A
V
G
I
A
Q
G
A
L
D
A
A
I
A
Y
T
K
E
R
K
Q
F
G
R
P
V
S
D
N
Q
G
V
Q
F
M
L
A
D
M
A
M
K
I
E
A
A
R
L
M
V
Y
S
A
A
A
R
A
E
R
G
-----------------
G
F
I
S
A
A
S
--
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
L
F
G
G
Y
G
Y
T
Q
D
F
P
V
E
R
M
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
Q
I
Q
R
V
V
M
S
R
A
L
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
97.61
91%
-76
- C1 -
3PFD
26
?
A:
[22-393]
----------------------------------
E
H
I
A
L
R
E
A
I
R
A
L
A
E
K
E
I
A
P
Y
A
A
E
V
D
E
K
-
A
R
F
P
E
E
A
L
A
A
L
N
S
S
G
F
S
A
I
H
V
P
E
E
Y
G
G
Q
G
A
---
D
S
---
V
A
T
C
I
V
I
E
E
V
A
R
V
D
C
S
-
A
S
L
-
I
P
-
A
V
N
-
K
-
L
G
T
M
G
L
I
L
R
-
G
S
E
E
L
K
K
Q
V
L
P
A
V
A
S
G
E
A
M
A
S
Y
A
L
S
E
R
E
A
G
S
D
A
A
S
M
R
T
R
A
-
V
--
A
D
G
D
-
D
W
I
L
N
G
S
K
C
W
I
T
N
G
G
K
S
T
W
Y
T
V
M
A
V
T
D
P
D
----
K
G
A
---
N
G
-----
I
S
A
F
M
V
H
K
D
D
E
G
F
T
V
G
P
K
E
R
K
L
G
I
K
G
S
P
T
T
E
L
Y
F
E
N
C
R
I
P
G
D
R
I
I
G
E
P
G
T
G
F
K
T
A
L
A
T
L
D
H
T
R
P
T
I
G
A
Q
A
V
G
I
A
Q
G
A
L
D
A
A
I
A
Y
T
K
E
R
K
Q
F
G
R
P
V
S
D
N
Q
G
V
Q
F
M
L
A
D
M
A
M
K
I
E
A
A
R
L
M
V
Y
S
A
A
A
R
A
E
R
G
-----------------
G
F
I
S
A
A
S
--
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
L
F
G
G
Y
G
Y
T
Q
D
F
P
V
E
R
M
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
Q
I
Q
R
V
V
M
S
R
A
L
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
97.35
91%
-76
- C1 -
3PFD
7
?
C:
[23-393]
-----------------------------------
H
I
A
L
R
E
A
I
R
A
L
A
E
K
E
I
A
P
Y
A
A
E
V
D
E
K
-
A
R
F
P
E
E
A
L
A
A
L
N
S
S
G
F
S
A
I
H
V
P
E
E
Y
G
G
Q
G
A
---
D
S
---
V
A
T
C
I
V
I
E
E
V
A
R
V
D
C
S
-
A
S
L
-
I
P
-
A
V
N
-
K
-
L
G
T
M
G
L
I
L
R
-
G
S
E
E
L
K
K
Q
V
L
P
A
V
A
S
G
E
A
M
A
S
Y
A
L
S
E
R
E
A
G
S
D
A
A
S
M
R
T
R
A
-
V
--
A
D
G
D
-
D
W
I
L
N
G
S
K
C
W
I
T
N
G
G
K
S
T
W
Y
T
V
M
A
V
T
D
P
D
----
K
G
A
---
N
G
-----
I
S
A
F
M
V
H
K
D
D
E
G
F
T
V
G
P
K
E
R
K
L
G
I
K
G
S
P
T
T
E
L
Y
F
E
N
C
R
I
P
G
D
R
I
I
G
E
P
G
T
G
F
K
T
A
L
A
T
L
D
H
T
R
P
T
I
G
A
Q
A
V
G
I
A
Q
G
A
L
D
A
A
I
A
Y
T
K
E
R
K
Q
F
G
R
P
V
S
D
N
Q
G
V
Q
F
M
L
A
D
M
A
M
K
I
E
A
A
R
L
M
V
Y
S
A
A
A
R
A
E
R
G
---------------
D
L
G
F
I
S
A
A
S
--
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
L
F
G
G
Y
G
Y
T
Q
D
F
P
V
E
R
M
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
Q
I
Q
R
V
V
M
S
R
A
L
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------
113
HHSearch
96.82
90%
-76
- C1 -
3PFD
26
?
A:
[22-393]
----------------------------------
E
H
I
A
L
R
E
A
I
R
A
L
A
E
K
E
I
A
P
Y
A
A
E
V
D
E
K
-
A
R
F
P
E
E
A
L
A
A
L
N
S
S
G
F
S
A
I
H
V
P
E
E
Y
G
G
Q
G
A
---
D
S
---
V
A
T
C
I
V
I
E
E
V
A
R
V
D
C
S
-
A
S
L
-
I
P
A
V
N
K
-
L
--
G
T
M
G
L
I
L
R
-
G
S
E
E
L
K
K
Q
V
L
P
A
V
A
S
G
E
A
M
A
S
Y
A
L
S
E
R
E
A
G
S
D
A
A
S
M
R
T
R
A
-
V
--
A
D
G
D
-
D
W
I
L
N
G
S
K
C
W
I
T
N
G
G
K
S
T
W
Y
T
V
M
A
V
T
D
P
D
----
K
G
A
---
N
G
-----
I
S
A
F
M
V
H
K
D
D
E
G
F
T
V
G
P
K
E
R
K
L
G
I
K
G
S
P
T
T
E
L
Y
F
E
N
C
R
I
P
G
D
R
I
I
G
E
P
G
T
G
F
K
T
A
L
A
T
L
D
H
T
R
P
T
I
G
A
Q
A
V
G
I
A
Q
G
A
L
D
A
A
I
A
Y
T
K
E
R
K
Q
F
G
R
P
V
S
D
N
Q
G
V
Q
F
M
L
A
D
M
A
M
K
I
E
A
A
R
L
M
V
Y
S
A
A
A
R
A
E
R
G
-----------------
G
F
I
S
A
A
S
--
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
L
F
G
G
Y
G
Y
T
Q
D
F
P
V
E
R
M
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
Q
I
Q
R
V
V
M
S
R
A
L
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
84.89
47%
-68
- C1 -
4L1F
5
?
B:
[3-379]
---------------------
F
N
L
T
--------
E
D
Q
Q
M
I
K
D
M
A
A
E
F
A
E
K
F
L
A
P
T
V
E
E
R
D
K
A
-
H
I
W
D
R
K
L
I
D
K
M
G
E
A
G
F
C
G
I
C
F
P
E
E
Y
G
G
M
G
L
---
D
V
---
L
S
Y
I
L
A
V
E
E
L
S
K
V
D
D
G
-
T
G
I
-
T
L
-
S
A
N
V
S
-
L
C
A
T
P
I
Y
M
F
-
G
T
E
E
Q
K
Q
K
Y
L
A
P
I
A
E
G
T
H
V
G
A
F
G
L
T
E
P
S
A
G
T
D
A
S
A
Q
Q
T
T
A
-
V
--
L
K
G
D
-
K
Y
I
L
N
G
S
K
I
F
I
T
N
G
K
E
A
D
T
Y
V
V
F
A
M
T
D
K
S
----
Q
G
V
---
H
G
-----
I
S
A
F
I
L
E
K
G
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
C
E
V
P
K
E
N
L
L
G
K
E
G
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
R
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
A
D
M
A
T
K
I
E
A
A
R
Y
L
V
Y
H
A
A
M
L
K
N
E
G
K
P
--------------
Y
S
E
A
A
A
M
A
--
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
R
A
L
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------
124
HHSearch
84.28
38%
-73
- C1 -
2JIF
9
ACDSB_HUMAN
A:
[25-402]
-------------------
P
L
Q
T
F
T
--------
D
E
E
M
M
I
K
S
S
V
K
K
F
A
Q
E
Q
I
A
P
L
V
S
T
M
D
E
N
-
S
K
M
E
K
S
V
I
Q
G
L
F
Q
Q
G
L
M
G
I
E
V
D
P
E
Y
G
G
T
G
A
---
S
F
---
L
S
T
V
L
V
I
E
E
L
A
K
V
D
A
S
-
V
A
V
-
F
C
E
I
Q
N
-
T
-
L
I
N
T
L
I
R
K
H
-
G
T
E
E
Q
K
A
T
Y
L
P
Q
L
T
T
E
-
K
V
G
S
F
C
L
S
E
A
G
A
G
S
D
S
F
A
L
K
T
R
A
-
D
--
K
E
G
D
-
Y
Y
V
L
N
G
S
K
M
W
I
S
S
A
E
H
A
G
L
F
L
V
M
A
N
V
D
P
T
----
I
G
Y
---
K
G
-----
I
T
S
F
L
V
D
R
D
T
P
G
L
H
I
G
K
P
E
N
K
L
G
L
R
A
S
S
T
C
P
L
T
F
E
N
V
K
V
P
E
A
N
I
L
G
Q
I
G
H
G
Y
K
Y
A
I
G
S
L
N
E
G
R
I
G
I
A
A
Q
M
L
G
L
A
Q
G
C
F
D
Y
T
I
P
Y
I
K
E
R
I
Q
F
G
K
R
L
F
D
F
Q
G
L
Q
H
Q
V
A
H
V
A
T
Q
L
E
A
A
R
L
L
T
Y
N
A
A
R
L
L
E
A
-
G
K
-------------
P
F
I
K
E
A
S
M
A
--
K
Y
Y
A
S
E
I
A
G
Q
T
T
S
K
C
I
E
W
M
G
G
V
G
Y
T
K
D
Y
P
V
E
K
Y
F
R
D
A
K
I
G
T
I
Y
E
G
A
S
N
I
Q
L
N
T
I
A
K
H
I
D
A
-------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
84.20
47%
-67
- C1 -
4L1F
7
?
A:
[3-379]
---------------------
F
N
L
T
--------
E
D
Q
Q
M
I
K
D
M
A
A
E
F
A
E
K
F
L
A
P
T
V
E
E
R
D
K
A
-
H
I
W
D
R
K
L
I
D
K
M
G
E
A
G
F
C
G
I
C
F
P
E
E
Y
G
G
M
G
L
---
D
V
---
L
S
Y
I
L
A
V
E
E
L
S
K
V
D
D
G
-
T
G
I
-
T
L
-
S
A
N
V
S
-
L
C
A
T
P
I
Y
M
F
-
G
T
E
E
Q
K
Q
K
Y
L
A
P
I
A
E
G
T
H
V
G
A
F
G
L
T
E
P
S
A
G
T
D
A
S
A
Q
Q
T
T
A
-
V
--
L
K
G
D
-
K
Y
I
L
N
G
S
K
I
F
I
T
N
G
K
E
A
D
T
Y
V
V
F
A
M
T
D
K
S
----
Q
G
V
---
H
G
-----
I
S
A
F
I
L
E
K
G
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
C
E
V
P
K
E
N
L
L
G
K
E
G
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
R
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
A
D
M
A
T
K
I
E
A
A
R
Y
L
V
Y
H
A
A
M
L
K
N
E
G
K
P
--------------
Y
S
E
A
A
A
M
A
--
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
R
A
L
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
83.89
43%
-70
- C1 -
1JQI
4
ACADS_RAT
A:
[5-384]
------------------
Y
Q
S
V
E
L
P
--------
E
T
H
Q
M
L
R
Q
T
C
R
D
F
A
E
K
E
L
V
P
I
A
A
Q
L
D
K
E
-
H
L
F
P
T
S
Q
V
K
K
M
G
E
L
G
L
L
A
M
D
V
P
E
E
L
S
G
A
G
L
---
D
Y
---
L
A
Y
S
I
A
L
E
E
I
S
R
G
C
A
S
-
T
G
V
-
I
M
-
S
V
N
-
N
-
S
L
Y
L
G
P
I
L
K
F
G
S
S
Q
Q
K
Q
Q
W
I
T
P
F
T
N
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
-
R
--
E
E
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
S
W
E
A
S
A
T
V
V
F
A
S
T
D
R
S
----
R
Q
N
---
K
G
-----
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
A
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
E
N
L
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
A
S
L
D
C
A
V
K
Y
A
E
N
R
H
A
F
G
A
P
L
T
K
L
Q
N
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
P
--------------
F
T
K
E
S
A
M
A
--
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
Y
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
83.70
39%
-75
- C1 -
2JIF
9
ACDSB_HUMAN
C:
[31-400]
---------------------------------
D
E
E
M
M
I
K
S
S
V
K
K
F
A
Q
E
Q
I
A
P
L
V
S
T
M
D
E
N
-
S
K
M
E
K
S
V
I
Q
G
L
F
Q
Q
G
L
M
G
I
E
V
D
P
E
Y
G
G
T
G
A
---
S
F
---
L
S
T
V
L
V
I
E
E
L
A
K
V
D
A
S
-
V
A
V
-
F
C
-
E
I
Q
-
N
-
T
L
I
N
T
L
I
R
K
H
G
T
E
E
Q
K
A
T
Y
L
P
Q
L
T
T
E
-
K
V
G
S
F
C
L
S
E
A
G
A
G
S
D
S
F
A
L
K
T
R
A
-
D
--
K
E
G
D
-
Y
Y
V
L
N
G
S
K
M
W
I
S
S
A
E
H
A
G
L
F
L
V
M
A
N
V
D
P
T
----
I
G
Y
---
K
G
-----
I
T
S
F
L
V
D
R
D
T
P
G
L
H
I
G
K
P
E
N
K
L
G
L
R
A
S
S
T
C
P
L
T
F
E
N
V
K
V
P
E
A
N
I
L
G
Q
I
G
H
G
Y
K
Y
A
I
G
S
L
N
E
G
R
I
G
I
A
A
Q
M
L
G
L
A
Q
G
C
F
D
Y
T
I
P
Y
I
K
E
R
I
Q
F
G
K
R
L
F
D
F
Q
G
L
Q
H
Q
V
A
H
V
A
T
Q
L
E
A
A
R
L
L
T
Y
N
A
A
R
L
L
E
A
G
K
P
----------------
F
I
K
E
A
S
MA
K
Y
Y
A
S
E
I
A
G
Q
T
T
S
K
C
I
E
W
M
G
G
V
G
Y
T
K
D
Y
P
V
E
K
Y
F
R
D
A
K
I
G
T
I
Y
E
G
A
S
N
I
Q
L
N
T
I
A
K
H
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
83.64
43%
-70
- C1 -
1JQI
4
ACADS_RAT
B:
[5-384]
------------------
Y
Q
S
V
E
L
P
--------
E
T
H
Q
M
L
R
Q
T
C
R
D
F
A
E
K
E
L
V
P
I
A
A
Q
L
D
K
E
-
H
L
F
P
T
S
Q
V
K
K
M
G
E
L
G
L
L
A
M
D
V
P
E
E
L
S
G
A
G
L
---
D
Y
---
L
A
Y
S
I
A
L
E
E
I
S
R
G
C
A
S
-
T
G
V
-
I
M
-
S
V
N
-
N
-
S
L
Y
L
G
P
I
L
K
F
G
S
S
Q
Q
K
Q
Q
W
I
T
P
F
T
N
G
D
K
I
G
C
F
A
L
S
E
P
G
N
G
S
D
A
G
A
A
S
T
T
A
-
R
--
E
E
G
D
-
S
W
V
L
N
G
T
K
A
W
I
T
N
S
W
E
A
S
A
T
V
V
F
A
S
T
D
R
S
----
R
Q
N
---
K
G
-----
I
S
A
F
L
V
P
M
P
T
P
G
L
T
L
G
K
K
E
D
K
L
G
I
R
A
S
S
T
A
N
L
I
F
E
D
C
R
I
P
K
E
N
L
L
G
E
P
G
M
G
F
K
I
A
M
Q
T
L
D
M
G
R
I
G
I
A
S
Q
A
L
G
I
A
Q
A
S
L
D
C
A
V
K
Y
A
E
N
R
H
A
F
G
A
P
L
T
K
L
Q
N
I
Q
F
K
L
A
D
M
A
L
A
L
E
S
A
R
L
L
T
W
R
A
A
M
L
K
D
N
K
K
P
--------------
F
T
K
E
S
A
M
A
--
K
L
A
A
S
E
A
A
T
A
I
S
H
Q
A
I
Q
I
L
G
G
M
G
Y
V
T
E
M
P
A
E
R
Y
Y
R
D
A
R
I
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
G
H
L
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
83.62
39%
-76
- C1 -
2JIF
9
ACDSB_HUMAN
A:
[31-400]
---------------------------------
D
E
E
M
M
I
K
S
S
V
K
K
F
A
Q
E
Q
I
A
P
L
V
S
T
M
D
E
N
-
S
K
M
E
K
S
V
I
Q
G
L
F
Q
Q
G
L
M
G
I
E
V
D
P
E
Y
G
G
T
G
A
---
S
F
---
L
S
T
V
L
V
I
E
E
L
A
K
V
D
A
S
-
V
A
V
-
F
C
-
E
I
Q
-
N
-
T
L
I
N
T
L
I
R
K
H
G
T
E
E
Q
K
A
T
Y
L
P
Q
L
T
T
E
-
K
V
G
S
F
C
L
S
E
A
G
A
G
S
D
S
F
A
L
K
T
R
A
-
D
--
K
E
G
D
-
Y
Y
V
L
N
G
S
K
M
W
I
S
S
A
E
H
A
G
L
F
L
V
M
A
N
V
D
P
T
----
I
G
Y
---
K
G
-----
I
T
S
F
L
V
D
R
D
T
P
G
L
H
I
G
K
P
E
N
K
L
G
L
R
A
S
S
T
C
P
L
T
F
E
N
V
K
V
P
E
A
N
I
L
G
Q
I
G
H
G
Y
K
Y
A
I
G
S
L
N
E
G
R
I
G
I
A
A
Q
M
L
G
L
A
Q
G
C
F
D
Y
T
I
P
Y
I
K
E
R
I
Q
F
G
K
R
L
F
D
F
Q
G
L
Q
H
Q
V
A
H
V
A
T
Q
L
E
A
A
R
L
L
T
Y
N
A
A
R
L
L
E
A
G
K
P
----------------
F
I
K
E
A
S
M
A
K
Y
Y
A
S
E
I
A
G
Q
T
T
S
K
C
I
E
W
M
G
G
V
G
Y
T
K
D
Y
P
V
E
K
Y
F
R
D
A
K
I
G
T
I
Y
E
G
A
S
N
I
Q
L
N
T
I
A
K
H
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
83.60
42%
-67
- C1 -
1UKW
2
?
A:
[3-377]
---------------------
F
S
L
T
--------
E
E
Q
R
Q
L
Q
A
L
A
R
R
F
A
K
E
V
I
L
P
V
A
Q
E
Y
D
E
K
-
E
E
V
P
W
P
V
I
E
K
L
H
E
V
G
L
L
N
A
I
I
P
E
E
Y
G
G
M
G
L
---
K
M
---
L
D
E
V
I
V
G
E
E
L
A
Y
A
C
M
G
-
I
Y
T
-
I
P
-
M
A
S
-
D
-
L
G
I
T
P
V
L
L
A
-
G
T
E
E
Q
K
E
R
F
L
R
P
L
T
E
K
P
A
L
A
A
F
A
L
S
E
P
G
N
G
S
D
A
A
A
L
K
T
R
A
-
I
--
R
Q
G
D
-
H
Y
V
L
N
G
T
K
M
W
I
S
N
G
G
E
A
E
W
V
V
V
F
A
T
V
N
P
E
----
L
R
H
---
K
G
-----
V
V
A
L
V
V
E
R
G
T
P
G
F
K
A
I
K
I
H
G
K
M
G
Q
R
A
S
G
T
Y
E
L
V
F
E
D
V
K
V
P
V
E
N
R
L
G
E
E
G
E
G
F
K
I
A
M
Q
T
L
N
K
T
R
I
P
V
A
A
G
S
V
G
V
A
R
R
A
L
D
E
A
R
K
Y
A
K
E
R
E
A
F
G
E
P
I
A
N
F
Q
A
I
Q
F
K
L
V
D
M
L
I
G
I
E
T
A
R
M
Y
T
Y
Y
A
A
W
L
A
D
Q
G
L
P
-------------
H
-
A
H
A
S
A
I
A
--
K
A
Y
A
S
E
I
A
F
E
A
A
N
Q
A
I
Q
I
H
G
G
Y
G
Y
V
R
E
F
P
V
E
K
L
L
R
D
V
K
L
N
Q
I
Y
E
G
T
N
E
I
Q
R
L
I
I
A
R
H
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
83.56
42%
-67
- C1 -
1UKW
3
?
B:
[3-377]
---------------------
F
S
L
T
--------
E
E
Q
R
Q
L
Q
A
L
A
R
R
F
A
K
E
V
I
L
P
V
A
Q
E
Y
D
E
K
-
E
E
V
P
W
P
V
I
E
K
L
H
E
V
G
L
L
N
A
I
I
P
E
E
Y
G
G
M
G
L
---
K
M
---
L
D
E
V
I
V
G
E
E
L
A
Y
A
C
M
G
-
I
Y
T
-
I
P
-
M
A
S
-
D
-
L
G
I
T
P
V
L
L
A
-
G
T
E
E
Q
K
E
R
F
L
R
P
L
T
E
K
P
A
L
A
A
F
A
L
S
E
P
G
N
G
S
D
A
A
A
L
K
T
R
A
-
I
--
R
Q
G
D
-
H
Y
V
L
N
G
T
K
M
W
I
S
N
G
G
E
A
E
W
V
V
V
F
A
T
V
N
P
E
----
L
R
H
---
K
G
-----
V
V
A
L
V
V
E
R
G
T
P
G
F
K
A
I
K
I
H
G
K
M
G
Q
R
A
S
G
T
Y
E
L
V
F
E
D
V
K
V
P
V
E
N
R
L
G
E
E
G
E
G
F
K
I
A
M
Q
T
L
N
K
T
R
I
P
V
A
A
G
S
V
G
V
A
R
R
A
L
D
E
A
R
K
Y
A
K
E
R
E
A
F
G
E
P
I
A
N
F
Q
A
I
Q
F
K
L
V
D
M
L
I
G
I
E
T
A
R
M
Y
T
Y
Y
A
A
W
L
A
D
Q
G
L
P
-------------
H
-
A
H
A
S
A
I
A
--
K
A
Y
A
S
E
I
A
F
E
A
A
N
Q
A
I
Q
I
H
G
G
Y
G
Y
V
R
E
F
P
V
E
K
L
L
R
D
V
K
L
N
Q
I
Y
E
G
T
N
E
I
Q
R
L
I
I
A
R
H
I
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------
63
PsiBlast_CBE
83.23
39%
-75
- C1 -
2JIF
10
ACDSB_HUMAN
B:
[31-400]
---------------------------------
D
E
E
M
M
I
K
S
S
V
K
K
F
A
Q
E
Q
I
A
P
L
V
S
T
M
D
E
N
-
S
K
M
E
K
S
V
I
Q
G
L
F
Q
Q
G
L
M
G
I
E
V
D
P
E
Y
G
G
T
G
A
---
S
F
---
L
S
T
V
L
V
I
E
E
L
A
K
V
D
A
S
-
V
A
V
-
F
C
-
E
I
Q
-
N
-
T
L
I
N
T
L
I
R
K
H
G
T
E
E
Q
K
A
T
Y
L
P
Q
L
T
T
E
-
K
V
G
S
F
C
L
S
E
A
G
A
G
S
D
S
F
A
L
K
T
R
A
-
D
--
K
E
G
D
-
Y
Y
V
L
N
G
S
K
M
W
I
S
S
A
E
H
A
G
L
F
L
V
M
A
N
V
D
P
T
----
I
G
Y
---
K
G
-----
I
T
S
F
L
V
D
R
D
T
P
G
L
H
I
G
K
P
E
N
K
L
G
L
R
A
S
S
T
C
P
L
T
F
E
N
V
K
V
P
E
A
N
I
L
G
Q
I
G
H
G
Y
K
Y
A
I
G
S
L
N
E
G
R
I
G
I
A
A
Q
M
L
G
L
A
Q
G
C
F
D
Y
T
I
P
Y
I
K
E
R
I
Q
F
G
K
R
L
F
D
F
Q
G
L
Q
H
Q
V
A
H
V
A
T
Q
L
E
A
A
R
L
L
T
Y
N
A
A
R
L
L
E
A
G
K
P
----------------
F
I
K
E
A
S
M
A
K
Y
Y
A
S
E
I
A
G
Q
T
T
S
K
C
I
E
W
M
G
G
V
G
Y
T
K
D
Y
P
V
E
K
Y
F
R
D
A
K
I
G
T
I
Y
E
G
A
S
N
I
Q
L
N
T
I
A
K
H
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
83.17
39%
-75
- C1 -
2JIF
11
ACDSB_HUMAN
D:
[31-400]
---------------------------------
D
E
E
M
M
I
K
S
S
V
K
K
F
A
Q
E
Q
I
A
P
L
V
S
T
M
D
E
N
-
S
K
M
E
K
S
V
I
Q
G
L
F
Q
Q
G
L
M
G
I
E
V
D
P
E
Y
G
G
T
G
A
---
S
F
---
L
S
T
V
L
V
I
E
E
L
A
K
V
D
A
S
-
V
A
V
-
F
C
-
E
I
Q
-
N
-
T
L
I
N
T
L
I
R
K
H
G
T
E
E
Q
K
A
T
Y
L
P
Q
L
T
T
E
-
K
V
G
S
F
C
L
S
E
A
G
A
G
S
D
S
F
A
L
K
T
R
A
-
D
--
K
E
G
D
-
Y
Y
V
L
N
G
S
K
M
W
I
S
S
A
E
H
A
G
L
F
L
V
M
A
N
V
D
P
T
----
I
G
Y
---
K
G
-----
I
T
S
F
L
V
D
R
D
T
P
G
L
H
I
G
K
P
E
N
K
L
G
L
R
A
S
S
T
C
P
L
T
F
E
N
V
K
V
P
E
A
N
I
L
G
Q
I
G
H
G
Y
K
Y
A
I
G
S
L
N
E
G
R
I
G
I
A
A
Q
M
L
G
L
A
Q
G
C
F
D
Y
T
I
P
Y
I
K
E
R
I
Q
F
G
K
R
L
F
D
F
Q
G
L
Q
H
Q
V
A
H
V
A
T
Q
L
E
A
A
R
L
L
T
Y
N
A
A
R
L
L
E
A
G
K
P
----------------
F
I
K
E
A
S
MA
K
Y
Y
A
S
E
I
A
G
Q
T
T
S
K
C
I
E
W
M
G
G
V
G
Y
T
K
D
Y
P
V
E
K
Y
F
R
D
A
K
I
G
T
I
Y
E
G
A
S
N
I
Q
L
N
T
I
A
K
H
I
---------------------------------------------------------------------------------------------------------------------------------------------------------------
125
HHSearch
82.96
47%
-68
* C1 *
4L1F
7
?
A:
[2-379]
--------------------
D
F
N
L
T
--------
E
D
Q
Q
M
I
K
D
M
A
A
E
F
A
E
K
F
L
A
P
T
V
E
E
R
D
K
A
-
H
I
W
D
R
K
L
I
D
K
M
G
E
A
G
F
C
G
I
C
F
P
E
E
Y
G
G
M
G
L
---
D
V
---
L
S
Y
I
L
A
V
E
E
L
S
K
V
D
D
G
-
T
G
I
-
T
L
S
A
N
V
-
S
-
L
C
A
T
P
I
Y
M
F
-
G
T
E
E
Q
K
Q
K
Y
L
A
P
I
A
E
G
T
H
V
G
A
F
G
L
T
E
P
S
A
G
T
D
A
S
A
Q
Q
T
T
A
-
V
--
L
K
G
D
-
K
Y
I
L
N
G
S
K
I
F
I
T
N
G
K
E
A
D
T
Y
V
V
F
A
M
T
D
K
S
----
Q
G
V
---
H
G
-----
I
S
A
F
I
L
E
K
G
M
P
G
F
R
F
G
K
I
E
D
K
M
G
G
H
T
S
I
T
A
E
L
I
F
E
D
C
E
V
P
K
E
N
L
L
G
K
E
G
E
G
F
K
I
A
M
E
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
G
A
L
A
A
A
V
K
Y
S
K
E
R
E
Q
F
G
R
S
I
S
K
F
Q
A
L
Q
F
M
M
A
D
M
A
T
K
I
E
A
A
R
Y
L
V
Y
H
A
A
M
L
K
N
E
-
G
K
-------------
P
Y
S
E
A
A
A
M
A
--
K
C
F
A
S
D
V
A
M
E
V
T
T
D
A
V
Q
I
F
G
G
Y
G
Y
T
V
D
Y
P
A
E
R
Y
M
R
N
A
K
I
T
Q
I
Y
E
G
T
N
Q
V
M
R
I
V
T
S
R
A
L
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------
75
PsiBlast_CBE
82.48
36%
-64
- C1 -
1RX0
9
ACAD8_HUMAN
C:
[19-392]
-----------------------
L
N
--------
E
E
Q
K
E
F
Q
K
V
A
F
D
F
A
A
R
E
M
A
P
N
M
A
E
W
D
Q
K
-
E
L
F
P
V
D
V
M
R
K
A
A
Q
L
G
F
G
G
V
Y
I
Q
T
D
V
G
G
S
G
L
---
S
R
---
L
D
T
S
V
I
F
E
A
L
A
T
G
C
T
S
-
T
T
A
-
Y
I
-
S
I
H
-
N
-
M
C
A
W
M
I
D
S
F
-
G
N
E
E
Q
R
H
K
F
C
P
P
L
C
T
M
E
K
F
A
S
Y
C
L
T
E
P
G
S
G
S
D
A
A
S
L
L
T
S
A
-
K
--
K
Q
G
D
-
H
Y
I
L
N
G
S
K
A
F
I
S
G
A
G
E
S
D
I
Y
V
V
M
C
R
T
G
G
P
-----
G
P
---
K
G
-----
I
S
C
I
V
V
E
K
G
T
P
G
L
S
F
G
K
K
E
K
K
V
G
W
N
S
Q
P
T
R
A
V
I
F
E
D
C
A
V
P
V
A
N
R
I
G
S
E
G
Q
G
F
L
I
A
V
R
G
L
N
G
G
R
I
N
I
A
S
C
S
L
G
A
A
H
A
S
V
I
L
T
R
D
H
L
N
V
R
K
Q
F
G
E
P
L
A
S
N
Q
Y
L
Q
F
T
L
A
D
M
A
T
R
L
V
A
A
R
L
M
V
R
N
A
A
V
A
L
Q
E
E
R
K
-------------
D
A
V
A
L
C
S
M
A
--
K
L
F
A
T
D
E
C
F
A
I
C
N
Q
A
L
Q
M
H
G
G
Y
G
Y
L
K
D
Y
A
V
Q
Q
Y
V
R
D
S
R
V
H
Q
I
L
E
G
S
N
E
V
M
R
I
L
I
S
R
S
L
L
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------
101
Fugue
82.00
42%
-66
- C1 -
1BUC
3
ACDS_MEGEL
A:
[1-383]
-------------------
M
D
F
N
L
T
--------
D
I
Q
Q
D
F
L
K
L
A
H
D
F
G
E
K
K
L
A
P
T
V
T
E
R
D
H
K
-
G
I
Y
D
K
E
L
I
D
E
L
L
S
L
G
I
T
G
A
Y
F
E
E
K
Y
G
G
S
G
D
DGG
D
V
---
L
S
Y
I
L
A
V
E
E
L
A
K
Y
D
A
G
-
V
A
I
-
T
L
-
S
A
T
-
V
S
L
C
A
N
P
I
W
Q
F
-
G
T
E
A
Q
K
E
K
F
L
V
P
L
V
E
G
T
K
L
G
A
F
G
L
T
E
P
N
A
G
T
D
A
S
G
Q
Q
T
I
A
-
T
--
K
N
D
D
G
T
Y
T
L
N
G
S
K
I
F
I
T
N
G
G
A
A
D
I
Y
I
V
F
A
M
T
D
K
S
----
K
G
N
---
H
G
-----
I
T
A
F
I
L
E
D
G
T
P
G
F
T
Y
G
K
K
E
D
K
M
G
I
H
T
S
Q
T
M
E
L
V
F
Q
D
V
K
V
P
A
E
N
M
L
G
E
E
G
K
G
F
K
I
A
M
M
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
A
D
A
V
E
Y
S
K
Q
R
V
Q
F
G
K
P
L
C
K
F
Q
S
I
S
F
K
L
A
D
M
K
M
Q
I
E
A
A
R
N
L
V
Y
K
A
A
C
K
K
Q
E
G
K
P
--------------
F
T
V
D
A
A
I
A
--
K
R
V
A
S
D
V
A
M
R
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
E
V
Q
L
M
V
T
G
G
A
L
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------
74
PsiBlast_CBE
81.96
36%
-64
- C1 -
1RX0
12
ACAD8_HUMAN
D:
[19-392]
-----------------------
L
N
--------
E
E
Q
K
E
F
Q
K
V
A
F
D
F
A
A
R
E
M
A
P
N
M
A
E
W
D
Q
K
-
E
L
F
P
V
D
V
M
R
K
A
A
Q
L
G
F
G
G
V
Y
I
Q
T
D
V
G
G
S
G
L
---
S
R
---
L
D
T
S
V
I
F
E
A
L
A
T
G
C
T
S
-
T
T
A
-
Y
I
-
S
I
H
-
N
-
M
C
A
W
M
I
D
S
F
-
G
N
E
E
Q
R
H
K
F
C
P
P
L
C
T
M
E
K
F
A
S
Y
C
L
T
E
P
G
S
G
S
D
A
A
S
L
L
T
S
A
-
K
--
K
Q
G
D
-
H
Y
I
L
N
G
S
K
A
F
I
S
G
A
G
E
S
D
I
Y
V
V
M
C
R
T
G
G
P
-----
G
P
---
K
G
-----
I
S
C
I
V
V
E
K
G
T
P
G
L
S
F
G
K
K
E
K
K
V
G
W
N
S
Q
P
T
R
A
V
I
F
E
D
C
A
V
P
V
A
N
R
I
G
S
E
G
Q
G
F
L
I
A
V
R
G
L
N
G
G
R
I
N
I
A
S
C
S
L
G
A
A
H
A
S
V
I
L
T
R
D
H
L
N
V
R
K
Q
F
G
E
P
L
A
S
N
Q
Y
L
Q
F
T
L
A
D
M
A
T
R
L
V
A
A
R
L
M
V
R
N
A
A
V
A
L
Q
E
E
R
K
-------------
D
A
V
A
L
C
S
M
A
--
K
L
F
A
T
D
E
C
F
A
I
C
N
Q
A
L
Q
M
H
G
G
Y
G
Y
L
K
D
Y
A
V
Q
Q
Y
V
R
D
S
R
V
H
Q
I
L
E
G
S
N
E
V
M
R
I
L
I
S
R
S
L
L
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------
34
PsiBlast_CBE
81.58
42%
-65
- C1 -
3MDE
4
ACADM_PIG
B:
[4-378]
---------------------
F
E
L
T
--------
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
R
T
-
G
E
Y
P
V
P
L
L
K
R
A
W
E
L
G
L
M
N
T
H
I
P
E
S
F
G
G
L
G
L
---
G
I
---
I
D
S
C
L
I
T
E
E
L
A
Y
G
C
T
G
-
V
Q
T
-
A
I
-
E
A
N
-
T
-
L
G
Q
V
P
L
I
I
G
-
G
N
Y
Q
Q
Q
K
K
Y
L
G
R
M
T
E
E
P
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
-
E
--
K
K
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
P
D
----
P
K
A
PAS
K
A
-----
F
T
G
F
I
V
E
A
D
T
P
G
V
Q
I
G
R
K
E
I
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
G
E
G
A
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
M
A
M
K
V
E
L
A
R
L
S
Y
Q
R
A
A
W
E
I
D
S
G
R
R
-------------
N
T
Y
Y
A
S
I
A
---
K
A
Y
A
A
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
35
PsiBlast_CBE
81.53
42%
-63
- C1 -
3MDD
2
ACADM_PIG
B:
[4-378]
---------------------
F
E
L
T
--------
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
R
T
-
G
E
Y
P
V
P
L
L
K
R
A
W
E
L
G
L
M
N
T
H
I
P
E
S
F
G
G
L
G
L
---
G
I
---
I
D
S
C
L
I
T
E
E
L
A
Y
G
C
T
G
-
V
Q
T
-
A
I
-
E
A
N
-
T
-
L
G
Q
V
P
L
I
I
G
-
G
N
Y
Q
Q
Q
K
K
Y
L
G
R
M
T
E
E
P
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
-
E
--
K
K
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
P
D
----
P
K
A
PAS
K
A
-----
F
T
G
F
I
V
E
A
D
T
P
G
V
Q
I
G
R
K
E
I
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
G
E
G
A
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
M
A
M
K
V
E
L
A
R
L
S
Y
Q
R
A
A
W
E
I
D
S
G
R
R
-------------
N
T
Y
Y
A
S
I
A
---
K
A
Y
A
A
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
80.83
42%
-69
- C1 -
1BUC
3
ACDS_MEGEL
A:
[3-383]
---------------------
F
N
L
T
--------
D
I
Q
Q
D
F
L
K
L
A
H
D
F
G
E
K
K
L
A
P
T
V
T
E
R
D
H
K
-
G
I
Y
D
K
E
L
I
D
E
L
L
S
L
G
I
T
G
A
Y
F
E
E
K
Y
G
G
S
G
D
---
D
G
GD
V
L
S
Y
I
L
A
V
E
E
L
A
K
Y
D
A
G
-
V
A
I
T
L
S
-
A
T
V
-
S
-
L
C
A
N
P
I
W
Q
F
-
G
T
E
A
Q
K
E
K
F
L
V
P
L
V
E
G
T
K
L
G
A
F
G
L
T
E
P
N
A
G
T
D
A
S
G
Q
Q
T
I
A
T
K
--
N
D
D
G
-
T
Y
T
L
N
G
S
K
I
F
I
T
N
G
G
A
A
D
I
Y
I
V
F
A
M
T
D
K
S
----
K
G
N
---
H
G
-----
I
T
A
F
I
L
E
D
G
T
P
G
F
T
Y
G
K
K
E
D
K
M
G
I
H
T
S
Q
T
M
E
L
V
F
Q
D
V
K
V
P
A
E
N
M
L
G
E
E
G
K
G
F
K
I
A
M
M
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
A
D
A
V
E
Y
S
K
Q
R
V
Q
F
G
K
P
L
C
K
F
Q
S
I
S
F
K
L
A
D
M
K
M
Q
I
E
A
A
R
N
L
V
Y
K
A
A
C
K
K
Q
E
G
K
P
--------------
F
T
V
D
A
A
I
A
--
K
R
V
A
S
D
V
A
M
R
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
E
V
Q
L
M
V
T
G
G
A
L
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
80.35
42%
-67
- C1 -
3MDD
2
ACADM_PIG
A:
[4-378]
---------------------
F
E
L
T
--------
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
R
T
-
G
E
Y
P
V
P
L
L
K
R
A
W
E
L
G
L
M
N
T
H
I
P
E
S
F
G
G
L
G
L
---
G
I
---
I
D
S
C
L
I
T
E
E
L
A
Y
G
C
T
G
-
V
Q
T
-
A
I
-
E
A
N
-
T
-
L
G
Q
V
P
L
I
I
G
-
G
N
Y
Q
Q
Q
K
K
Y
L
G
R
M
T
E
E
P
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
-
E
--
K
K
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
P
D
----
P
K
A
PAS
K
A
-----
F
T
G
F
I
V
E
A
D
T
P
G
V
Q
I
G
R
K
E
I
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
G
E
G
A
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
M
A
M
K
V
E
L
A
R
L
S
Y
Q
R
A
A
W
E
I
D
S
G
R
R
-------------
N
T
Y
Y
A
S
I
A
---
K
A
Y
A
A
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
80.29
42%
-66
- C1 -
3MDE
3
ACADM_PIG
A:
[4-378]
---------------------
F
E
L
T
--------
E
Q
Q
K
E
F
Q
A
T
A
R
K
F
A
R
E
E
I
I
P
V
A
A
E
Y
D
R
T
-
G
E
Y
P
V
P
L
L
K
R
A
W
E
L
G
L
M
N
T
H
I
P
E
S
F
G
G
L
G
L
---
G
I
---
I
D
S
C
L
I
T
E
E
L
A
Y
G
C
T
G
-
V
Q
T
-
A
I
-
E
A
N
-
T
-
L
G
Q
V
P
L
I
I
G
-
G
N
Y
Q
Q
Q
K
K
Y
L
G
R
M
T
E
E
P
L
M
C
A
Y
C
V
T
E
P
G
A
G
S
D
V
A
G
I
K
T
K
A
-
E
--
K
K
G
D
-
E
Y
I
I
N
G
Q
K
M
W
I
T
N
G
G
K
A
N
W
Y
F
L
L
A
R
S
D
P
D
----
P
K
A
PAS
K
A
-----
F
T
G
F
I
V
E
A
D
T
P
G
V
Q
I
G
R
K
E
I
N
M
G
Q
R
C
S
D
T
R
G
I
V
F
E
D
V
R
V
P
K
E
N
V
L
T
G
E
G
A
G
F
K
I
A
M
G
T
F
D
K
T
R
P
P
V
A
A
G
A
V
G
L
A
Q
R
A
L
D
E
A
T
K
Y
A
L
E
R
K
T
F
G
K
L
L
A
E
H
Q
G
I
S
F
L
L
A
D
M
A
M
K
V
E
L
A
R
L
S
Y
Q
R
A
A
W
E
I
D
S
G
R
R
-------------
N
T
Y
Y
A
S
I
A
---
K
A
Y
A
A
D
I
A
N
Q
L
A
T
D
A
V
Q
V
F
G
G
N
G
F
N
T
E
Y
P
V
E
K
L
M
R
D
A
K
I
Y
Q
I
Y
E
G
T
A
Q
I
Q
R
I
I
I
A
R
-----------------------------------------------------------------------------------------------------------------------------------------------------------------
130
HHSearch
80.17
39%
-66
- C1 -
2D29
2
?
A:
[3-385]
-------------------
L
W
F
E
E
G
--------
A
E
E
R
Q
V
L
G
P
F
R
E
F
L
K
A
E
V
A
P
G
A
A
E
R
D
R
T
-
G
A
F
P
W
D
L
V
R
K
L
A
E
F
G
V
F
G
A
L
V
P
E
A
Y
G
G
A
G
L
---
S
T
---
R
L
F
A
R
M
V
E
A
I
A
Y
Y
D
G
A
-
L
A
L
-
T
V
A
S
H
N
-
S
-
L
A
T
G
H
I
L
L
A
-
G
S
E
A
Q
K
E
A
F
L
P
K
L
A
S
G
E
A
L
G
A
W
G
L
T
E
P
G
S
G
S
D
A
A
A
L
K
T
K
A
-
E
--
K
V
E
G
-
G
W
R
L
N
G
T
K
Q
F
I
T
Q
G
S
V
A
G
V
Y
V
V
M
A
R
T
D
P
P
PSPE
R
K
H
---
Q
G
-----
I
S
A
F
A
F
F
R
P
E
R
G
L
K
V
G
R
K
E
E
K
L
G
L
T
A
S
D
T
A
Q
L
I
L
E
D
L
F
V
P
E
E
A
L
L
G
E
R
G
K
G
F
Y
D
V
L
R
V
L
D
G
G
R
I
G
I
A
A
M
A
V
G
L
G
Q
A
A
L
D
Y
A
L
A
Y
A
K
G
R
E
A
F
G
R
P
I
A
E
F
E
G
V
S
F
K
L
A
E
A
A
T
E
L
E
A
A
R
L
L
Y
L
K
A
A
E
L
K
D
A
-
G
R
-------------
P
F
T
L
E
A
A
Q
A
--
K
L
F
A
S
E
A
A
V
K
A
C
D
E
A
I
Q
I
L
G
G
Y
G
Y
V
K
D
Y
P
V
E
R
Y
W
R
D
A
R
L
T
R
I
G
E
G
T
S
E
I
L
K
L
V
I
A
R
R
L
L
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------
102
Fugue
79.90
34%
-65
- C1 -
2Z1Q
2
?
B:
[5-577]
KKLWQKGGG
W
L
L
E
V
P
E
R
V
Y
T
P
E
D
F
D
--------
E
S
V
K
E
I
A
R
T
T
R
T
F
V
E
R
E
V
L
P
L
L
E
R
M
E
H
G
E
L
E
L
N
V
P
L
M
R
K
A
G
E
L
G
L
L
A
I
D
V
P
E
E
Y
G
G
L
D
L
---
P
K
---
V
I
S
T
V
V
A
E
E
L
S
G
S
G
G
F
-
S
V
T
-
Y
G
-
A
H
T
-
S
-
I
G
T
L
P
L
V
Y
F
-
G
T
E
E
Q
K
R
K
Y
L
P
K
L
A
S
G
E
W
I
A
A
Y
C
L
T
E
P
G
S
G
S
D
A
L
A
A
K
T
R
A
-
T
L
S
E
D
G
K
-
H
Y
I
L
N
G
V
K
Q
W
I
S
N
A
G
F
A
H
L
F
T
V
F
A
K
V
D
G
E
-----------
H
-----
F
T
A
F
L
V
E
R
D
T
P
G
L
S
F
G
P
E
E
K
K
M
G
I
K
A
S
S
T
R
Q
V
I
L
E
D
V
K
V
P
V
E
N
V
L
G
E
I
G
K
G
H
K
I
A
F
N
V
L
N
V
G
R
Y
K
L
G
A
G
A
V
G
G
A
K
R
A
L
E
L
S
A
Q
Y
A
T
Q
R
V
Q
F
G
R
P
I
G
R
F
G
L
I
Q
Q
K
L
G
E
M
A
S
R
I
Y
A
A
E
S
A
V
Y
R
T
V
G
L
I
D
E
A
L
L
GKKG
P
E
A
V
M
A
G
I
E
E
Y
A
V
E
A
S
I
I
--
K
V
L
G
S
E
V
L
D
Y
V
V
D
E
G
V
Q
I
H
G
G
Y
G
Y
S
Q
E
Y
P
I
E
R
A
Y
R
D
A
R
I
N
R
I
F
E
G
T
N
E
I
N
R
L
L
I
P
G
M
L
L
R
RAEPED
L
E
L
H
Q
V
Q
N
L
K
K
L
A
L
M
V
A
G
L
A
V
Q
K
YGQGVEEE
Q
E
V
L
G
A
V
A
D
I
L
I
D
A
Y
A
A
E
S
A
L
L
R
A
R
R
L
GGL
A
P
V
L
A
R
I
Y
L
A
Q
A
L
D
R
A
Q
A
G
A
L
S
V
LPRLVEG
D
E
A
R
V
V
Y
S
A
A
R
R
L
T
KREPGD
L
V
A
L
R
R
Q
A
A
E
A
V
L
E
A
GGYPIPR------------------
69
PsiBlast_CBE
79.83
42%
-71
- C1 -
2DVL
2
?
A:
[3-372]
-----------------------
L
T
--------
Q
E
Q
R
L
V
L
D
A
V
R
R
V
A
R
E
V
L
Y
P
L
A
P
E
Y
D
R
K
-
A
E
Y
P
W
P
Q
L
K
A
L
A
E
L
G
L
L
G
M
T
T
P
E
E
W
G
G
V
G
L
---
D
S
---
V
T
W
A
L
A
L
E
E
L
A
A
A
D
P
S
-
V
A
V
-
I
V
-
S
V
T
-
S
-
G
L
P
Q
Y
M
L
L
R
F
G
S
E
A
Q
K
R
R
Y
L
V
P
L
A
R
G
E
W
I
G
A
F
C
L
T
E
P
Q
A
G
S
D
A
K
S
L
R
A
E
A
-
R
--
R
V
K
G
-
G
F
V
L
N
G
V
K
S
W
I
T
S
A
G
H
A
H
L
Y
V
V
M
A
R
T
E
------------
K
G
-----
I
S
A
F
L
V
E
K
G
T
P
G
L
S
F
G
R
P
E
E
K
M
G
L
H
A
A
H
T
A
E
V
R
L
E
E
V
F
V
P
E
E
N
L
L
G
E
E
G
R
G
L
A
Y
A
L
A
G
L
D
S
G
R
V
G
V
A
A
Q
A
V
G
I
A
R
G
A
F
E
I
A
K
A
Y
A
E
E
R
E
Q
F
G
K
K
L
K
E
H
Q
A
I
A
F
K
I
A
D
M
H
V
K
I
A
A
A
R
A
L
V
L
E
A
A
R
K
K
D
R
G
E
--------------
R
F
T
L
E
A
S
A
A
--
K
L
F
A
S
A
A
A
V
E
V
T
R
E
A
V
Q
V
L
G
G
Y
G
Y
H
R
D
Y
R
V
E
R
Y
Y
R
D
A
K
V
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
R
E
L
Y
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
79.71
43%
-67
- C1 -
4N5F
10
?
A:
[15-385]
---------------------------------
E
D
Q
R
M
I
R
D
A
A
R
A
F
A
T
E
M
L
A
P
N
A
A
Q
W
D
H
D
-
A
H
L
P
D
A
I
V
A
Q
L
G
E
L
G
L
L
G
M
I
V
P
Q
E
L
G
G
S
Y
T
---
D
Y
---
V
A
Y
A
L
A
M
E
E
V
A
A
G
D
A
A
C
A
T
M
-
M
S
-
V
H
N
-
S
-
V
G
C
G
P
I
L
G
F
-
G
T
P
A
Q
K
D
R
W
L
A
D
M
A
A
G
R
V
I
G
A
F
C
L
T
E
P
H
A
G
S
E
A
N
N
L
R
T
R
A
-
E
--
L
R
D
G
-
Q
W
V
L
N
G
A
K
Q
F
V
T
N
G
Q
R
A
G
V
A
I
V
F
A
M
T
D
P
E
----
A
G
K
---
R
G
-----
I
S
A
F
L
V
P
T
D
T
P
G
F
I
V
G
K
P
E
K
K
M
G
I
R
A
S
D
T
C
P
I
T
F
E
N
C
A
I
P
E
D
N
L
L
G
N
R
G
E
G
L
K
I
A
L
S
N
L
E
G
G
R
I
G
I
A
A
Q
A
L
G
I
A
R
A
A
F
D
K
A
R
R
Y
A
G
E
R
V
Q
F
G
K
P
I
A
E
H
Q
A
I
Q
Q
K
L
A
D
M
A
V
Q
I
N
A
A
R
L
L
V
H
H
A
A
K
L
R
T
A
G
L
P
-------------
C
L
S
E
A
S
Q
A
---
K
L
F
A
S
E
M
A
E
R
V
C
S
D
A
I
Q
I
H
G
G
Y
G
Y
L
V
D
Y
E
V
E
R
H
Y
R
D
A
R
I
T
Q
I
Y
E
G
T
S
E
V
Q
R
M
V
I
A
R
Q
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------
64
PsiBlast_CBE
79.61
42%
-73
- C1 -
1BUC
3
ACDS_MEGEL
B:
[3-383]
---------------------
F
N
L
T
--------
D
I
Q
Q
D
F
L
K
L
A
H
D
F
G
E
K
K
L
A
P
T
V
T
E
R
D
H
K
-
G
I
Y
D
K
E
L
I
D
E
L
L
S
L
G
I
T
G
A
Y
F
E
E
K
Y
G
G
S
G
D
---
D
G
GDV
L
S
Y
I
L
A
V
E
E
L
A
K
Y
D
A
G
-
V
A
I
T
L
S
-
A
T
V
-
S
-
L
C
A
N
P
I
W
Q
F
-
G
T
E
A
Q
K
E
K
F
L
V
P
L
V
E
G
T
K
L
G
A
F
G
L
T
E
P
N
A
G
T
D
A
S
G
Q
Q
T
I
A
T
K
--
N
D
D
G
-
T
Y
T
L
N
G
S
K
I
F
I
T
N
G
G
A
A
D
I
Y
I
V
F
A
M
T
D
K
S
----
K
G
N
---
H
G
-----
I
T
A
F
I
L
E
D
G
T
P
G
F
T
Y
G
K
K
E
D
K
M
G
I
H
T
S
Q
T
M
E
L
V
F
Q
D
V
K
V
P
A
E
N
M
L
G
E
E
G
K
G
F
K
I
A
M
M
T
L
D
G
G
R
I
G
V
A
A
Q
A
L
G
I
A
E
A
A
L
A
D
A
V
E
Y
S
K
Q
R
V
Q
F
G
K
P
L
C
K
F
Q
S
I
S
F
K
L
A
D
M
K
M
Q
I
E
A
A
R
N
L
V
Y
K
A
A
C
K
K
Q
E
G
K
P
--------------
F
T
V
D
A
A
I
A
--
K
R
V
A
S
D
V
A
M
R
V
T
T
E
A
V
Q
I
F
G
G
Y
G
Y
S
E
E
Y
P
V
A
R
H
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
E
V
Q
L
M
V
T
G
G
A
L
L
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
79.05
42%
-71
- C1 -
3NF4
1
?
A:
[15-386]
-----------------------
L
P
S-------
Q
E
A
A
E
L
I
E
L
T
R
E
I
A
D
K
V
L
D
P
I
V
D
R
H
E
K
D
-
E
T
Y
P
E
G
V
F
E
Q
L
G
A
A
G
L
L
S
L
P
Q
P
E
E
W
G
G
G
G
Q
---
P
Y
---
E
V
Y
L
Q
V
L
E
E
I
A
A
R
W
A
S
-
V
A
V
-
A
V
-
S
V
H
-
S
-
L
S
S
H
P
L
L
V
F
-
G
T
E
E
Q
K
K
R
W
L
P
G
M
L
S
G
E
Q
I
G
A
Y
S
L
S
E
P
Q
A
G
S
D
A
A
A
L
R
C
A
A
-
T
--
P
T
D
G
-
G
Y
V
I
N
G
S
K
S
W
I
T
H
G
G
K
A
D
F
Y
T
L
F
A
R
T
G
--------
S
---
R
G
-----
V
S
C
F
L
V
P
A
D
Q
P
G
L
S
F
G
K
P
E
E
K
M
G
L
H
A
V
P
T
T
S
A
F
Y
D
N
A
R
I
D
A
D
R
R
I
G
E
E
G
Q
G
L
Q
I
A
F
S
A
L
D
S
G
R
L
G
I
A
A
V
A
T
G
L
A
Q
A
A
L
D
E
A
V
A
Y
A
N
E
------
K
I
I
D
H
-
G
L
G
F
L
L
A
D
M
A
A
A
V
A
T
A
R
A
T
Y
L
D
A
A
R
R
R
D
Q
G
R
P
-------------
Y
S
Q
Q
A
S
I
A
---
K
L
T
A
T
D
A
A
M
K
V
T
T
D
A
V
Q
V
F
G
G
V
G
Y
T
R
D
Y
R
V
E
R
Y
M
R
E
A
K
I
M
Q
I
F
E
G
T
N
Q
I
Q
R
L
V
I
A
R
G
L
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
78.90
42%
-68
- C1 -
2DVL
2
?
B:
[3-372]
-----------------------
L
T
--------
Q
E
Q
R
L
V
L
D
A
V
R
R
V
A
R
E
V
L
Y
P
L
A
P
E
Y
D
R
K
-
A
E
Y
P
W
P
Q
L
K
A
L
A
E
L
G
L
L
G
M
T
T
P
E
E
W
G
G
V
G
L
---
D
S
---
V
T
W
A
L
A
L
E
E
L
A
A
A
D
P
S
-
V
A
V
-
I
V
-
S
V
T
-
S
-
G
L
P
Q
Y
M
L
L
R
F
G
S
E
A
Q
K
R
R
Y
L
V
P
L
A
R
G
E
W
I
G
A
F
C
L
T
E
P
Q
A
G
S
D
A
K
S
L
R
A
E
A
-
R
--
R
V
K
G
-
G
F
V
L
N
G
V
K
S
W
I
T
S
A
G
H
A
H
L
Y
V
V
M
A
R
T
E
------------
K
G
-----
I
S
A
F
L
V
E
K
G
T
P
G
L
S
F
G
R
P
E
E
K
M
G
L
H
A
A
H
T
A
E
V
R
L
E
E
V
F
V
P
E
E
N
L
L
G
E
E
G
R
G
L
A
Y
A
L
A
G
L
D
S
G
R
V
G
V
A
A
Q
A
V
G
I
A
R
G
A
F
E
I
A
K
A
Y
A
E
E
R
E
Q
F
G
K
K
L
K
E
H
Q
A
I
A
F
K
I
A
D
M
H
V
K
I
A
A
A
R
A
L
V
L
E
A
A
R
K
K
D
R
G
E
--------------
R
F
T
L
E
A
S
A
A
--
K
L
F
A
S
A
A
A
V
E
V
T
R
E
A
V
Q
V
L
G
G
Y
G
Y
H
R
D
Y
R
V
E
R
Y
Y
R
D
A
K
V
T
E
I
Y
E
G
T
S
E
I
Q
R
L
V
I
A
R
E
L
Y
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------
116
HHSearch
78.79
41%
-74
- C1 -
3NF4
1
?
A:
[13-386]
--------------------
R
L
L
P
S
--------
Q
E
A
A
E
L
I
E
L
T
R
E
I
A
D
K
V
L
D
P
I
V
D
R
H
E
K
D
-
E
T
Y
P
E
G
V
F
E
Q
L
G
A
A
G
L
L
S
L
P
Q
P
E
E
W
G
G
G
G
Q
---
P
Y
---
E
V
Y
L
Q
V
L
E
E
I
A
A
R
W
A
S
-
V
A
V
-
A
V
S
V
H
S
---
L
S
S
H
P
L
L
V
F
-
G
T
E
E
Q
K
K
R
W
L
P
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M
L
S
G
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G
A
Y
S
L
S
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P
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A
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D
A
A
A
L
R
C
A
A
-
T
--
P
T
D
G
-
G
Y
V
I
N
G
S
K
S
W
I
T
H
G
G
K
A
D
F
Y
T
L
F
A
R
T
G
--------
S
---
R
G
-----
V
S
C
F
L
V
P
A
D
Q
P
G
L
S
F
G
K
P
E
E
K
M
G
L
H
A
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P
T
T
S
A
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N
A
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A
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R
R
I
G
E
E
G
Q
G
L
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I
A
F
S
A
L
D
S
G
R
L
G
I
A
A
V
A
T
G
L
A
Q
A
A
L
D
E
A
V
A
Y
A
N
E
------
K
I
I
D
H
-
G
L
G
F
L
L
A
D
M
A
A
A
V
A
T
A
R
A
T
Y
L
D
A
A
R
R
R
D
Q
-
G
R
-------------
P
Y
S
Q
Q
A
S
I
A
--
K
L
T
A
T
D
A
A
M
K
V
T
T
D
A
V
Q
V
F
G
G
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Y
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M
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G
T
N
Q
I
Q
R
L
V
I
A
R
G
L
T
--------------------------------------------------------------------------------------------------------------------------------------------------------------
103
Fugue
76.26
33%
-66
- C1 -
2UXW
4
ACADV_HUMAN
A:
[21-607]
--QSMS
F
A
V
G
M
F
K
G
Q
L
T
T
D
Q
V
F
P
Y
P
SVLN
E
E
Q
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L
K
E
L
V
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F
F
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N
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--
P
A
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N
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A
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-
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M
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T
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W
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G
L
K
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L
G
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E
L
G
G
V
G
L
---
C
N
---
T
Q
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A
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L
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E
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M
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-
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A
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A
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P
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C
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K
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Y
Y
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N
G
G
L
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F
A
K
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V
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----
D
P
A
---
T
G
A
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K
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K
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A
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N
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A
A
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A
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-------------
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L
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A
L
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N
PFGSGLSLSGLVHPEL
S
R
S
G
E
L
A
V
R
A
L
E
Q
F
A
T
V
V
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A
K
L
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HKKGIVNE
Q
F
L
L
Q
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L
A
D
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A
I
D
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Y
A
M
V
V
V
L
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GHPT
A
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C
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A
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A
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SDPW
Q
Q
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R
N
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A
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R
GGVVTSNPLGF