@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3279c: (2016-05-18 )
MTDRDRLRPPLDERSLRDQLIGAGSGWRQLDVVAQTGSTNADLLARAASGADIDGVVLIAEHQTAGRGRHGRGWAATARAQIILSVGVRVVDVPVQAWGWLSLAAGLAVLDSVAPLIAVPPAETGLKWPNDVLARGGKLAGILAEVAQPFVVLGVGLNVTQAPEEVDPDATSLLDLGVAAPDRNRIASRLLRELEARIIQWRNANPQLAADYRARSLTIGSRVRVELPGGQDVVGIARDIDDQGRLCLDVGGRTVVVSAGDVVHLR
Atome Classification :
(29 SA)
.........10........20........30-----........40........50........60........70........80........90........100.......110.......120.......130.......140.......150---.........160.......170.......180.......190....--...200.......210.......220.......230.......240.......250.......260....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTDRDRLRPP
L
D
E
R
S
L
R
D
Q
L
IGAGSG
W
R
Q
L
D
-----
V
V
A
QTGST
N
A
D
L
L
A
RAASGADI
D
G
V
V
L
I
A
EHQTAGRGRHGR
G
W
A
A
T
A
R
A
Q
I
I
L
S
V
G
V
R
V
V
DVPVQA
W
G
W
L
S
L
A
A
G
L
A
V
L
D
SVA
P
L
I
AVPPAETGLKW
P
N
D
V
L
ARGG
K
L
A
G
I
L
A
E
VAQ
P
F
-----
V
V
L
GVGLNVTQAPEEVDP
D
A
T
S
L
L
D
LGVAAP
D
R
N
R
I
A
S
R
L
L
R
E
L
E
A
--
R
I
I
Q
WRNANPQ
L
A
A
DYR
A
R
S
L
T
IG
S
R
V
R
V
ELPGGQ
D
V
V
G
I
ARDIDDQG
R
L
C
L
DVGG
R
T
V
V
V
SAG
D
V
V
HLR
10
PsiBlast_PDB
89.44
99%
-117
- C5 -
4XTZ
1
?
A:
[5-270]
V
T
D
R
D
R
L
R
P
P
L
D
E
R
S
L
R
D
Q
L
I
G
A
G
S
G
W
R
Q
L
D
-----
V
V
A
Q
T
G
S
T
N
A
D
L
L
A
R
A
A
S
G
A
D
I
D
G
V
V
L
I
A
E
H
Q
T
A
G
R
G
R
H
G
R
G
W
A
A
T
A
R
A
Q
I
I
L
S
V
G
V
R
V
V
D
V
P
V
Q
A
W
G
W
L
S
L
A
A
G
L
A
V
L
D
S
V
A
P
L
I
A
V
P
P
A
E
T
G
L
K
W
P
N
D
V
L
A
R
G
G
K
L
A
G
I
L
A
E
V
A
Q
P
F
-----
V
V
L
G
V
G
L
N
V
T
Q
A
P
E
E
V
D
P
D
A
T
S
L
L
D
L
G
V
A
A
P
D
R
N
R
I
A
S
R
L
L
R
E
L
E
A
--
R
I
I
Q
W
R
N
A
N
P
Q
L
A
A
D
Y
R
A
R
S
L
T
I
G
S
R
V
R
V
E
L
P
G
G
Q
D
V
V
G
I
A
R
D
I
D
D
Q
G
R
L
C
L
D
V
G
G
R
T
V
V
V
S
A
G
D
V
V
H
L
R
8
PsiBlast_PDB
89.20
99%
-121
- C5 -
4XTX
2
?
A:
[5-270]
V
T
D
R
D
R
L
R
P
P
L
D
E
R
S
L
R
D
Q
L
I
G
A
G
S
G
W
R
Q
L
D
-----
V
V
A
Q
T
G
S
T
N
A
D
L
L
A
R
A
A
S
G
A
D
I
D
G
V
V
L
I
A
E
H
Q
T
A
G
R
G
R
H
G
R
G
W
A
A
T
A
R
A
Q
I
I
L
S
V
G
V
R
V
V
D
V
P
V
Q
A
W
G
W
L
S
L
A
A
G
L
A
V
L
D
S
V
A
P
L
I
A
V
P
P
A
E
T
G
L
K
W
P
N
D
V
L
A
R
G
G
K
L
A
G
I
L
A
E
V
A
Q
P
F
-----
V
V
L
G
V
G
L
N
V
T
Q
A
P
E
E
V
D
P
D
A
T
S
L
L
D
L
G
V
A
A
P
D
R
N
R
I
A
S
R
L
L
R
E
L
E
A
--
R
I
I
Q
W
R
N
A
N
P
Q
L
A
A
D
Y
R
A
R
S
L
T
I
G
S
R
V
R
V
E
L
P
G
G
Q
D
V
V
G
I
A
R
D
I
D
D
Q
G
R
L
C
L
D
V
G
G
R
T
V
V
V
S
A
G
D
V
V
H
L
R
24
PsiBlast_CBE
89.15
99%
-120
- C5 -
4XU1
2
?
B:
[8-270]
---
R
D
R
L
R
P
P
L
D
E
R
S
L
R
D
Q
L
I
G
A
G
S
G
W
R
Q
L
D
-----
V
V
A
Q
T
G
S
T
N
A
D
L
L
A
R
A
A
S
G
A
D
I
D
G
V
V
L
I
A
E
H
Q
T
A
G
R
G
R
H
G
R
G
W
A
A
T
A
R
A
Q
I
I
L
S
V
G
V
R
V
V
D
V
P
V
Q
A
W
G
W
L
S
L
A
A
G
L
A
V
L
D
S
V
A
P
L
I
A
V
P
P
A
E
T
G
L
K
W
P
N
D
V
L
A
R
G
G
K
L
A
G
I
L
A
E
V
A
Q
P
F
-----
V
V
L
G
V
G
L
N
V
T
Q
A
P
E
E
V
D
P
D
A
T
S
L
L
D
L
G
V
A
A
P
D
R
N
R
I
A
S
R
L
L
R
E
L
E
A
--
R
I
I
Q
W
R
N
A
N
P
Q
L
A
A
D
Y
R
A
R
S
L
T
I
G
S
R
V
R
V
E
L
P
G
G
Q
D
V
V
G
I
A
R
D
I
D
D
Q
G
R
L
C
L
D
V
G
G
R
T
V
V
V
S
A
G
D
V
V
H
L
R
48
HHSearch
88.96
100%
-117
- C5 -
4XTV
1
?
A:
[6-269]
-
T
D
R
D
R
L
R
P
P
L
D
E
R
S
L
R
D
Q
L
I
G
A
G
S
G
W
R
Q
L
D
-----
V
V
A
Q
T
G
S
T
N
A
D
L
L
A
R
A
A
S
G
A
D
I
D
G
V
V
L
I
A
E
H
Q
T
A
G
R
G
R
H
G
R
G
W
A
A
T
A
R
A
Q
I
I
L
S
V
G
V
R
V
V
D
V
P
V
Q
A
W
G
W
L
S
L
A
A
G
L
A
V
L
D
S
V
A
P
L
I
A
V
P
P
A
E
T
G
L
K
W
P
N
D
V
L
A
R
G
G
K
L
A
G
I
L
A
E
V
A
Q
P
F
-----
V
V
L
G
V
G
L
N
V
T
Q
A
P
E
E
V
D
P
D
A
T
S
L
L
D
L
G
V
A
A
P
D
R
N
R
I
A
S
R
L
L
R
E
L
E
A
--
R
I
I
Q
W
R
N
A
N
P
Q
L
A
A
D
Y
R
A
R
S
L
T
I
G
S
R
V
R
V
E
L
P
G
G
Q
D
V
V
G
I
A
R
D
I
D
D
Q
G
R
L
C
L
D
V
G
G
R
T
V
V
V
S
A
G
D
V
V
H
L
-
15
PsiBlast_PDB
88.83
99%
-115
- C5 -
4XTU
1
?
A:
[5-270]
V
T
D
R
D
R
L
R
P
P
L
D
E
R
S
L
R
D
Q
L
I
G
A
G
S
G
W
R
Q
L
D
-----
V
V
A
Q
T
G
S
T
N
A
D
L
L
A
R
A
A
S
G
A
D
I
D
G
V
V
L
I
A
E
H
Q
T
A
G
R
G
R
H
G
R
G
W
A
A
T
A
R
A
Q
I
I
L
S
V
G
V
R
V
V
D
V
P
V
Q
A
W
G
W
L
S
L
A
A
G
L
A
V
L
D
S
V
A
P
L
I
A
V
P
P
A
E
T
G
L
K
W
P
N
D
V
L
A
R
G
G
K
L
A
G
I
L
A
E
V
A
Q
P
F
-----
V
V
L
G
V
G
L
N
V
T
Q
A
P
E
E
V
D
P
D
A
T
S
L
L
D
L
G
V
A
A
P
D
R
N
R
I
A
S
R
L
L
R
E
L
E
A
--
R
I
I
Q
W
R
N
A
N
P
Q
L
A
A
D
Y
R
A
R
S
L
T
I
G
S
R
V
R
V
E
L
P
G
G
Q
D
V
V
G
I
A
R
D
I
D
D
Q
G
R
L
C
L
D
V
G
G
R
T
V
V
V
S
A
G
D
V
V
H
L
R
6
PsiBlast_PDB
88.76
99%
-117
- C5 -
4XTV
1
?
A:
[6-269]
-
T
D
R
D
R
L
R
P
P
L
D
E
R
S
L
R
D
Q
L
I
G
A
G
S
G
W
R
Q
L
D
-----
V
V
A
Q
T
G
S
T
N
A
D
L
L
A
R
A
A
S
G
A
D
I
D
G
V
V
L
I
A
E
H
Q
T
A
G
R
G
R
H
G
R
G
W
A
A
T
A
R
A
Q
I
I
L
S
V
G
V
R
V
V
D
V
P
V
Q
A
W
G
W
L
S
L
A
A
G
L
A
V
L
D
S
V
A
P
L
I
A
V
P
P
A
E
T
G
L
K
W
P
N
D
V
L
A
R
G
G
K
L
A
G
I
L
A
E
V
A
Q
P
F
-----
V
V
L
G
V
G
L
N
V
T
Q
A
P
E
E
V
D
P
D
A
T
S
L
L
D
L
G
V
A
A
P
D
R
N
R
I
A
S
R
L
L
R
E
L
E
A
--
R
I
I
Q
W
R
N
A
N
P
Q
L
A
A
D
Y
R
A
R
S
L
T
I
G
S
R
V
R
V
E
L
P
G
G
Q
D
V
V
G
I
A
R
D
I
D
D
Q
G
R
L
C
L
D
V
G
G
R
T
V
V
V
S
A
G
D
V
V
H
L
-
12
PsiBlast_PDB
88.64
99%
-120
- C5 -
4XU1
3
?
A:
[7-269]
--
D
R
D
R
L
R
P
P
L
D
E
R
S
L
R
D
Q
L
I
G
A
G
S
G
W
R
Q
L
D
-----
V
V
A
Q
T
G
S
T
N
A
D
L
L
A
R
A
A
S
G
A
D
I
D
G
V
V
L
I
A
E
H
Q
T
A
G
R
G
R
H
G
R
G
W
A
A
T
A
R
A
Q
I
I
L
S
V
G
V
R
V
V
D
V
P
V
Q
A
W
G
W
L
S
L
A
A
G
L
A
V
L
D
S
V
A
P
L
I
A
V
P
P
A
E
T
G
L
K
W
P
N
D
V
L
A
R
G
G
K
L
A
G
I
L
A
E
V
A
Q
P
F
-----
V
V
L
G
V
G
L
N
V
T
Q
A
P
E
E
V
D
P
D
A
T
S
L
L
D
L
G
V
A
A
P
D
R
N
R
I
A
S
R
L
L
R
E
L
E
A
--
R
I
I
Q
W
R
N
A
N
P
Q
L
A
A
D
Y
R
A
R
S
L
T
I
G
S
R
V
R
V
E
L
P
G
G
Q
D
V
V
G
I
A
R
D
I
D
D
Q
G
R
L
C
L
D
V
G
G
R
T
V
V
V
S
A
G
D
V
V
H
L
-
28
PsiBlast_CBE
88.62
99%
-119
- C5 -
4XTX
1
?
B:
[8-270]
---
R
D
R
L
R
P
P
L
D
E
R
S
L
R
D
Q
L
I
G
A
G
S
G
W
R
Q
L
D
-----
V
V
A
Q
T
G
S
T
N
A
D
L
L
A
R
A
A
S
G
A
D
I
D
G
V
V
L
I
A
E
H
Q
T
A
G
R
G
R
H
G
R
G
W
A
A
T
A
R
A
Q
I
I
L
S
V
G
V
R
V
V
D
V
P
V
Q
A
W
G
W
L
S
L
A
A
G
L
A
V
L
D
S
V
A
P
L
I
A
V
P
P
A
E
T
G
L
K
W
P
N
D
V
L
A
R
G
G
K
L
A
G
I
L
A
E
V
A
Q
P
F
-----
V
V
L
G
V
G
L
N
V
T
Q
A
P
E
E
V
D
P
D
A
T
S
L
L
D
L
G
V
A
A
P
D
R
N
R
I
A
S
R
L
L
R
E
L
E
A
--
R
I
I
Q
W
R
N
A
N
P
Q
L
A
A
D
Y
R
A
R
S
L
T
I
G
S
R
V
R
V
E
L
P
G
G
Q
D
V
V
G
I
A
R
D
I
D
D
Q
G
R
L
C
L
D
V
G
G
R
T
V
V
V
S
A
G
D
V
V
H
L
R
7
PsiBlast_PDB
88.58
99%
-114
- C5 -
4XTW
2
?
A:
[5-270]
V
T
D
R
D
R
L
R
P
P
L
D
E
R
S
L
R
D
Q
L
I
G
A
G
S
G
W
R
Q
L
D
-----
V
V
A
Q
T
G
S
T
N
A
D
L
L
A
R
A
A
S
G
A
D
I
D
G
V
V
L
I
A
E
H
Q
T
A
G
R
G
R
H
G
R
G
W
A
A
T
A
R
A
Q
I
I
L
S
V
G
V
R
V
V
D
V
P
V
Q
A
W
G
W
L
S
L
A
A
G
L
A
V
L
D
S
V
A
P
L
I
A
V
P
P
A
E
T
G
L
K
W
P
N
D
V
L
A
R
G
G
K
L
A
G
I
L
A
E
V
A
Q
P
F
-----
V
V
L
G
V
G
L
N
V
T
Q
A
P
E
E
V
D
P
D
A
T
S
L
L
D
L
G
V
A
A
P
D
R
N
R
I
A
S
R
L
L
R
E
L
E
A
--
R
I
I
Q
W
R
N
A
N
P
Q
L
A
A
D
Y
R
A
R
S
L
T
I
G
S
R
V
R
V
E
L
P
G
G
Q
D
V
V
G
I
A
R
D
I
D
D
Q
G
R
L
C
L
D
V
G
G
R
T
V
V
V
S
A
G
D
V
V
H
L
R
5
PsiBlast_PDB
88.50
99%
-116
- C5 -
3RUX
1
?
A:
[6-270]
-
T
D
R
D
R
L
R
P
P
L
D
E
R
S
L
R
D
Q
L
I
G
A
G
S
G
W
R
Q
L
D
-----
V
V
A
Q
T
G
S
T
N
A
D
L
L
A
R
A
A
S
G
A
D
I
D
G
V
V
L
I
A
E
H
Q
T
A
G
R
G
R
H
G
R
G
W
A
A
T
A
R
A
Q
I
I
L
S
V
G
V
R
V
V
D
V
P
V
Q
A
W
G
W
L
S
L
A
A
G
L
A
V
L
D
S
V
A
P
L
I
A
V
P
P
A
E
T
G
L
K
W
P
N
D
V
L
A
R
G
G
K
L
A
G
I
L
A
E
V
A
Q
P
F
-----
V
V
L
G
V
G
L
N
V
T
Q
A
P
E
E
V
D
P
D
A
T
S
L
L
D
L
G
V
A
A
P
D
R
N
R
I
A
S
R
L
L
R
E
L
E
A
--
R
I
I
Q
W
R
N
A
N
P
Q
L
A
A
D
Y
R
A
R
S
L
T
I
G
S
R
V
R
V
E
L
P
G
G
Q
D
V
V
G
I
A
R
D
I
D
D
Q
G
R
L
C
L
D
V
G
G
R
T
V
V
V
S
A
G
D
V
V
H
L
R
22
PsiBlast_CBE
88.41
99%
-114
- C5 -
4XU3
1
?
B:
[7-270]
--
D
R
D
R
L
R
P
P
L
D
E
R
S
L
R
D
Q
L
I
G
A
G
S
G
W
R
Q
L
D
-----
V
V
A
Q
T
G
S
T
N
A
D
L
L
A
R
A
A
S
G
A
D
I
D
G
V
V
L
I
A
E
H
Q
T
A
G
R
G
R
H
G
R
G
W
A
A
T
A
R
A
Q
I
I
L
S
V
G
V
R
V
V
D
V
P
V
Q
A
W
G
W
L
S
L
A
A
G
L
A
V
L
D
S
V
A
P
L
I
A
V
P
--
E
T
G
L
K
W
P
N
D
V
L
A
R
G
G
K
L
A
G
I
L
A
E
V
A
Q
P
F
-----
V
V
L
G
V
G
L
N
V
T
Q
A
P
E
E
V
D
P
D
A
T
S
L
L
D
L
G
V
A
A
P
D
R
N
R
I
A
S
R
L
L
R
E
L
E
A
--
R
I
I
Q
W
R
N
A
N
P
Q
L
A
A
D
Y
R
A
R
S
L
T
I
G
S
R
V
R
V
E
L
P
G
G
Q
D
V
V
G
I
A
R
D
I
D
D
Q
G
R
L
C
L
D
V
G
G
R
T
V
V
V
S
A
G
D
V
V
H
L
R
11
PsiBlast_PDB
88.38
99%
-117
- C5 -
4XU0
1
?
A:
[6-270]
-
T
D
R
D
R
L
R
P
P
L
D
E
R
S
L
R
D
Q
L
I
G
A
G
S
G
W
R
Q
L
D
-----
V
V
A
Q
T
G
S
T
N
A
D
L
L
A
R
A
A
S
G
A
D
I
D
G
V
V
L
I
A
E
H
Q
T
A
G
R
G
R
H
G
R
G
W
A
A
T
A
R
A
Q
I
I
L
S
V
G
V
R
V
V
D
V
P
V
Q
A
W
G
W
L
S
L
A
A
G
L
A
V
L
D
S
V
A
P
L
I
A
V
P
P
A
E
T
G
L
K
W
P
N
D
V
L
A
R
G
G
K
L
A
G
I
L
A
E
V
A
Q
P
F
-----
V
V
L
G
V
G
L
N
V
T
Q
A
P
E
E
V
D
P
D
A
T
S
L
L
D
L
G
V
A
A
P
D
R
N
R
I
A
S
R
L
L
R
E
L
E
A
--
R
I
I
Q
W
R
N
A
N
P
Q
L
A
A
D
Y
R
A
R
S
L
T
I
G
S
R
V
R
V
E
L
P
G
G
Q
D
V
V
G
I
A
R
D
I
D
D
Q
G
R
L
C
L
D
V
G
G
R
T
V
V
V
S
A
G
D
V
V
H
L
R
9
PsiBlast_PDB
88.12
99%
-115
- C5 -
4XTY
1
?
A:
[6-269]
-
T
D
R
D
R
L
R
P
P
L
D
E
R
S
L
R
D
Q
L
I
G
A
G
S
G
W
R
Q
L
D
-----
V
V
A
Q
T
G
S
T
N
A
D
L
L
A
R
A
A
S
G
A
D
I
D
G
V
V
L
I
A
E
H
Q
T
A
G
R
G
R
H
G
R
G
W
A
A
T
A
R
A
Q
I
I
L
S
V
G
V
R
V
V
D
V
P
V
Q
A
W
G
W
L
S
L
A
A
G
L
A
V
L
D
S
V
A
P
L
I
A
V
P
P
A
E
T
G
L
K
W
P
N
D
V
L
A
R
G
G
K
L
A
G
I
L
A
E
V
A
Q
P
F
-----
V
V
L
G
V
G
L
N
V
T
Q
A
P
E
E
V
D
P
D
A
T
S
L
L
D
L
G
V
A
A
P
D
R
N
R
I
A
S
R
L
L
R
E
L
E
A
--
R
I
I
Q
W
R
N
A
N
P
Q
L
A
A
D
Y
R
A
R
S
L
T
I
G
S
R
V
R
V
E
L
P
G
G
Q
D
V
V
G
I
A
R
D
I
D
D
Q
G
R
L
C
L
D
V
G
G
R
T
V
V
V
S
A
G
D
V
V
H
L
-
25
PsiBlast_CBE
87.90
99%
-112
- C5 -
4XU0
1
?
B:
[7-270]
--
D
R
D
R
L
R
P
P
L
D
E
R
S
L
R
D
Q
L
I
G
A
G
S
G
W
R
Q
L
D
-----
V
V
A
Q
T
G
S
T
N
A
D
L
L
A
R
A
A
S
G
A
D
I
D
G
V
V
L
I
A
E
H
Q
T
A
G
R
G
R
H
G
R
G
W
A
A
T
A
R
A
Q
I
I
L
S
V
G
V
R
V
V
D
V
P
V
Q
A
W
G
W
L
S
L
A
A
G
L
A
V
L
D
S
V
A
P
L
I
A
V
P
--
E
T
G
L
K
W
P
N
D
V
L
A
R
G
G
K
L
A
G
I
L
A
E
V
A
Q
P
F
-----
V
V
L
G
V
G
L
N
V
T
Q
A
P
E
E
V
D
P
D
A
T
S
L
L
D
L
G
V
A
A
P
D
R
N
R
I
A
S
R
L
L
R
E
L
E
A
--
R
I
I
Q
W
R
N
A
N
P
Q
L
A
A
D
Y
R
A
R
S
L
T
I
G
S
R
V
R
V
E
L
P
G
G
Q
D
V
V
G
I
A
R
D
I
D
D
Q
G
R
L
C
L
D
V
G
G
R
T
V
V
V
S
A
G
D
V
V
H
L
R
13
PsiBlast_PDB
87.90
99%
-117
- C5 -
4XU2
1
?
A:
[7-270]
--
D
R
D
R
L
R
P
P
L
D
E
R
S
L
R
D
Q
L
I
G
A
G
S
G
W
R
Q
L
D
-----
V
V
A
Q
T
G
S
T
N
A
D
L
L
A
R
A
A
S
G
A
D
I
D
G
V
V
L
I
A
E
H
Q
T
A
G
R
G
R
H
G
R
G
W
A
A
T
A
R
A
Q
I
I
L
S
V
G
V
R
V
V
D
V
P
V
Q
A
W
G
W
L
S
L
A
A
G
L
A
V
L
D
S
V
A
P
L
I
--
P
P
A
E
T
G
L
K
W
P
N
D
V
L
A
R
G
G
K
L
A
G
I
L
A
E
V
A
Q
P
F
-----
V
V
L
G
V
G
L
N
V
T
Q
A
P
E
E
V
D
P
D
A
T
S
L
L
D
L
G
V
A
A
P
D
R
N
R
I
A
S
R
L
L
R
E
L
E
A
--
R
I
I
Q
W
R
N
A
N
P
Q
L
A
A
D
Y
R
A
R
S
L
T
I
G
S
R
V
R
V
E
L
P
G
G
Q
D
V
V
G
I
A
R
D
I
D
D
Q
G
R
L
C
L
D
V
G
G
R
T
V
V
V
S
A
G
D
V
V
H
L
R
27
PsiBlast_CBE
87.89
99%
-117
- C5 -
4XTY
1
?
B:
[8-270]
---
R
D
R
L
R
P
P
L
D
E
R
S
L
R
D
Q
L
I
G
A
G
S
G
W
R
Q
L
D
-----
V
V
A
Q
T
G
S
T
N
A
D
L
L
A
R
A
A
S
G
A
D
I
D
G
V
V
L
I
A
E
H
Q
T
A
G
R
G
R
H
G
R
G
W
A
A
T
A
R
A
Q
I
I
L
S
V
G
V
R
V
V
D
V
P
V
Q
A
W
G
W
L
S
L
A
A
G
L
A
V
L
D
S
V
A
P
L
I
A
V
P
--
E
T
G
L
K
W
P
N
D
V
L
A
R
G
G
K
L
A
G
I
L
A
E
V
A
Q
P
F
-----
V
V
L
G
V
G
L
N
V
T
Q
A
P
E
E
V
D
P
D
A
T
S
L
L
D
L
G
V
A
A
P
D
R
N
R
I
A
S
R
L
L
R
E
L
E
A
--
R
I
I
Q
W
R
N
A
N
P
Q
L
A
A
D
Y
R
A
R
S
L
T
I
G
S
R
V
R
V
E
L
P
G
G
Q
D
V
V
G
I
A
R
D
I
D
D
Q
G
R
L
C
L
D
V
G
G
R
T
V
V
V
S
A
G
D
V
V
H
L
R
30
PsiBlast_CBE
87.81
99%
-117
- C5 -
4XTV
1
?
B:
[7-270]
--
D
R
D
R
L
R
P
P
L
D
E
R
S
L
R
D
Q
L
I
G
A
G
S
G
W
R
Q
L
D
-----
V
V
A
Q
T
G
S
T
N
A
D
L
L
A
R
A
A
S
G
A
D
I
D
G
V
V
L
I
A
E
H
Q
T
A
G
R
G
R
H
G
R
G
W
A
A
T
A
R
A
Q
I
I
L
S
V
G
V
R
V
V
D
V
P
V
Q
A
W
G
W
L
S
L
A
A
G
L
A
V
L
D
S
V
A
P
L
I
A
V
P
--
E
T
G
L
K
W
P
N
D
V
L
A
R
G
G
K
L
A
G
I
L
A
E
V
A
Q
P
F
-----
V
V
L
G
V
G
L
N
V
T
Q
A
P
E
E
V
D
P
D
A
T
S
L
L
D
L
G
V
A
A
P
D
R
N
R
I
A
S
R
L
L
R
E
L
E
A
--
R
I
I
Q
W
R
N
A
N
P
Q
L
A
A
D
Y
R
A
R
S
L
T
I
G
S
R
V
R
V
E
L
P
G
G
Q
D
V
V
G
I
A
R
D
I
D
D
Q
G
R
L
C
L
D
V
G
G
R
T
V
V
V
S
A
G
D
V
V
H
L
R
29
PsiBlast_CBE
87.73
99%
-117
- C5 -
4XTW
1
?
B:
[8-270]
---
R
D
R
L
R
P
P
L
D
E
R
S
L
R
D
Q
L
I
G
A
G
S
G
W
R
Q
L
D
-----
V
V
A
Q
T
G
S
T
N
A
D
L
L
A
R
A
A
S
G
A
D
I
D
G
V
V
L
I
A
E
H
Q
T
A
G
R
G
R
H
G
R
G
W
A
A
T
A
R
A
Q
I
I
L
S
V
G
V
R
V
V
D
V
P
V
Q
A
W
G
W
L
S
L
A
A
G
L
A
V
L
D
S
V
A
P
L
I
A
V
----
T
G
L
K
W
P
N
D
V
L
A
R
G
G
K
L
A
G
I
L
A
E
V
A
Q
P
F
-----
V
V
L
G
V
G
L
N
V
T
Q
A
P
E
E
V
D
P
D
A
T
S
L
L
D
L
G
V
A
A
P
D
R
N
R
I
A
S
R
L
L
R
E
L
E
A
--
R
I
I
Q
W
R
N
A
N
P
Q
L
A
A
D
Y
R
A
R
S
L
T
I
G
S
R
V
R
V
E
L
P
G
G
Q
D
V
V
G
I
A
R
D
I
D
D
Q
G
R
L
C
L
D
V
G
G
R
T
V
V
V
S
A
G
D
V
V
H
L
R
32
PsiBlast_CBE
87.56
99%
-116
- C5 -
3RUX
1
?
B:
[8-270]
---
R
D
R
L
R
P
P
L
D
E
R
S
L
R
D
Q
L
I
G
A
G
S
G
W
R
Q
L
D
-----
V
V
A
Q
T
G
S
T
N
A
D
L
L
A
R
A
A
S
G
A
D
I
D
G
V
V
L
I
A
E
H
Q
T
A
G
R
G
R
H
G
R
G
W
A
A
T
A
R
A
Q
I
I
L
S
V
G
V
R
V
V
D
V
P
V
Q
A
W
G
W
L
S
L
A
A
G
L
A
V
L
D
S
V
A
P
L
I
A
V
--
A
E
T
G
L
K
W
P
N
D
V
L
A
R
G
G
K
L
A
G
I
L
A
E
V
A
Q
P
F
-----
V
V
L
G
V
G
L
N
V
T
Q
A
P
E
E
V
D
P
D
A
T
S
L
L
D
L
G
V
A
A
P
D
R
N
R
I
A
S
R
L
L
R
E
L
E
A
--
R
I
I
Q
W
R
N
A
N
P
Q
L
A
A
D
Y
R
A
R
S
L
T
I
G
S
R
V
R
V
E
L
P
G
G
Q
D
V
V
G
I
A
R
D
I
D
D
Q
G
R
L
C
L
D
V
G
G
R
T
V
V
V
S
A
G
D
V
V
H
L
R
23
PsiBlast_CBE
87.01
99%
-115
- C5 -
4XU2
1
?
B:
[8-270]
---
R
D
R
L
R
P
P
L
D
E
R
S
L
R
D
Q
L
I
G
A
G
S
G
W
R
Q
L
D
-----
V
V
A
Q
T
G
S
T
N
A
D
L
L
A
R
A
A
S
G
A
D
I
D
G
V
V
L
I
A
E
H
Q
T
A
G
R
G
R
H
G
R
G
W
A
A
T
A
R
A
Q
I
I
L
S
V
G
V
R
V
V
D
V
P
V
Q
A
W
G
W
L
S
L
A
A
G
L
A
V
L
D
S
V
A
P
L
I
-----
E
T
G
L
K
W
P
N
D
V
L
A
R
G
G
K
L
A
G
I
L
A
E
V
A
Q
P
F
-----
V
V
L
G
V
G
L
N
V
T
Q
A
P
E
E
V
D
P
D
A
T
S
L
L
D
L
G
V
A
A
P
D
R
N
R
I
A
S
R
L
L
R
E
L
E
A
--
R
I
I
Q
W
R
N
A
N
P
Q
L
A
A
D
Y
R
A
R
S
L
T
I
G
S
R
V
R
V
E
L
P
G
G
Q
D
V
V
G
I
A
R
D
I
D
D
Q
G
R
L
C
L
D
V
G
G
R
T
V
V
V
S
A
G
D
V
V
H
L
R
26
PsiBlast_CBE
86.98
99%
-114
- C5 -
4XTZ
1
?
B:
[8-270]
---
R
D
R
L
R
P
P
L
D
E
R
S
L
R
D
Q
L
I
G
A
G
S
G
W
R
Q
L
D
-----
V
V
A
Q
T
G
S
T
N
A
D
L
L
A
R
A
A
S
G
A
D
I
D
G
V
V
L
I
A
E
H
Q
T
A
G
R
G
R
H
G
R
G
W
A
A
T
A
R
A
Q
I
I
L
S
V
G
V
R
V
V
D
V
P
V
Q
A
W
G
W
L
S
L
A
A
G
L
A
V
L
D
S
V
A
P
L
I
A
V
--
A
E
T
G
L
K
W
P
N
D
V
L
A
R
G
G
K
L
A
G
I
L
A
E
V
A
Q
P
F
-----
V
V
L
G
V
G
L
N
V
T
Q
A
P
E
E
V
D
P
D
A
T
S
L
L
D
L
G
V
A
A
P
D
R
N
R
I
A
S
R
L
L
R
E
L
E
A
--
R
I
I
Q
W
R
N
A
N
P
Q
L
A
A
D
Y
R
A
R
S
L
T
I
G
S
R
V
R
V
E
L
P
G
G
Q
D
V
V
G
I
A
R
D
I
D
D
Q
G
R
L
C
L
D
V
G
G
R
T
V
V
V
S
A
G
D
V
V
H
L
R
31
PsiBlast_CBE
86.96
99%
-115
- C5 -
4XTU
1
?
B:
[8-270]
---
R
D
R
L
R
P
P
L
D
E
R
S
L
R
D
Q
L
I
G
A
G
S
G
W
R
Q
L
D
-----
V
V
A
Q
T
G
S
T
N
A
D
L
L
A
R
A
A
S
G
A
D
I
D
G
V
V
L
I
A
E
H
Q
T
A
G
R
G
R
H
G
R
G
W
A
A
T
A
R
A
Q
I
I
L
S
V
G
V
R
V
V
D
V
P
V
Q
A
W
G
W
L
S
L
A
A
G
L
A
V
L
D
S
V
A
P
L
I
A
V
--
A
E
T
G
L
K
W
P
N
D
V
L
A
R
G
G
K
L
A
G
I
L
A
E
V
A
Q
P
F
-----
V
V
L
G
V
G
L
N
V
T
Q
A
P
E
E
V
D
P
D
A
T
S
L
L
D
L
G
V
A
A
P
D
R
N
R
I
A
S
R
L
L
R
E
L
E
A
--
R
I
I
Q
W
R
N
A
N
P
Q
L
A
A
D
Y
R
A
R
S
L
T
I
G
S
R
V
R
V
E
L
P
G
G
Q
D
V
V
G
I
A
R
D
I
D
D
Q
G
R
L
C
L
D
V
G
G
R
T
V
V
V
S
A
G
D
V
V
H
L
R
14
PsiBlast_PDB
86.85
99%
-115
- C5 -
4XU3
2
?
A:
[7-270]
--
D
R
D
R
L
R
P
P
L
D
E
R
S
L
R
D
Q
L
I
G
A
G
S
G
W
R
Q
L
D
-----
V
V
A
Q
T
G
S
T
N
A
D
L
L
A
R
A
A
S
G
A
D
I
D
G
V
V
L
I
A
E
H
Q
T
A
G
R
G
R
H
G
R
G
W
A
A
T
A
R
A
Q
I
I
L
S
V
G
V
R
V
V
D
V
P
V
Q
A
W
G
W
L
S
L
A
A
G
L
A
V
L
D
S
V
A
P
L
I
-
V
P
P
A
E
T
G
L
K
W
P
N
D
V
L
A
R
G
G
K
L
A
G
I
L
A
E
V
A
Q
P
F
-----
V
V
L
G
V
G
L
N
V
T
Q
A
P
E
E
V
D
P
D
A
T
S
L
L
D
L
G
V
A
A
P
D
R
N
R
I
A
S
R
L
L
R
E
L
E
A
--
R
I
I
Q
W
R
N
A
N
P
Q
L
A
A
D
Y
R
A
R
S
L
T
I
G
S
R
V
R
V
E
L
P
G
G
Q
D
V
V
G
I
A
R
D
I
D
D
Q
G
R
L
C
L
D
V
G
G
R
T
V
V
V
S
A
G
D
V
V
H
L
R
21
PsiBlast_CBE
86.53
99%
-117
- C5 -
4OP0
2
?
B:
[5-267]
--
D
R
D
R
L
R
P
P
L
D
E
R
S
L
R
D
Q
L
I
G
--
S
G
W
R
Q
L
D
-----
V
V
A
Q
T
G
S
T
N
A
D
L
L
A
R
A
A
S
G
A
D
I
D
G
V
V
L
I
A
E
H
Q
T
A
G
R
G
R
H
G
R
G
W
A
A
T
A
R
A
Q
I
I
L
S
V
G
V
R
V
V
D
V
P
V
Q
A
W
G
W
L
S
L
A
A
G
L
A
V
L
D
S
V
A
P
L
I
A
----
E
T
G
L
K
W
P
N
D
V
L
A
R
G
G
K
L
A
G
I
L
A
E
V
A
Q
P
F
-----
V
V
L
G
V
G
L
N
V
T
Q
A
P
E
E
V
D
P
D
A
T
S
L
L
D
L
G
V
A
A
P
D
R
N
R
I
A
S
R
L
L
R
E
L
E
A
--
R
I
I
Q
W
R
N
A
N
P
Q
L
A
A
D
Y
R
A
R
S
L
T
I
G
S
R
V
R
V
E
L
P
G
G
Q
D
V
V
G
I
A
R
D
I
D
D
Q
G
R
L
C
L
D
V
G
G
R
T
V
V
V
S
A
G
D
V
V
H
L
-
4
PsiBlast_PDB
84.45
99%
-113
- C5 -
4OP0
1
?
A:
[3-267]
M
A
D
R
D
R
L
R
P
P
L
D
E
R
S
L
R
D
Q
L
I
G
A
G
S
G
W
R
Q
L
D
-----
V
V
A
Q
T
G
S
T
N
A
D
L
L
A
R
A
A
S
G
A
D
I
D
G
V
V
L
I
A
E
H
Q
T
A
G
R
G
R
H
G
R
G
W
A
A
T
A
R
A
Q
I
I
L
S
V
G
V
R
V
V
D
V
P
V
Q
A
W
G
W
L
S
L
A
A
G
L
A
V
L
D
S
V
A
P
L
I
------
T
G
L
K
W
P
N
D
V
L
A
R
G
G
K
L
A
G
I
L
A
E
V
A
Q
P
F
-----
V
V
L
G
V
G
L
N
V
T
Q
A
P
E
E
V
D
P
D
A
T
S
L
L
D
L
G
V
A
A
P
D
R
N
R
I
A
S
R
L
L
R
E
L
E
A
--
R
I
I
Q
W
R
N
A
N
P
Q
L
A
A
D
Y
R
A
R
S
L
T
I
G
S
R
V
R
V
E
L
P
G
G
Q
D
V
V
G
I
A
R
D
I
D
D
Q
G
R
L
C
L
D
V
G
G
R
T
V
V
V
S
A
G
D
V
V
H
L
-
17
PsiBlast_PDB
55.69
33%
-105
- C5 -
4WF2
1
BIRA_ECOLI
A:
[65-304]
------------------
Q
L
L
N
A
K
Q
I
L
G
Q
L
D
G
G
S
V
A
V
L
P
V
I
D
S
T
N
Q
Y
L
L
D
R
I
--
G
E
L
K
S
G
D
A
C
I
A
E
Y
Q
Q
A
G
R
G
R
R
G
R
K
W
F
S
P
F
G
A
N
L
Y
L
S
M
F
W
R
L
E
Q
A
P
A
A
A
I
G
-
L
S
L
V
I
G
I
V
M
A
E
V
L
R
K
L
G
A
---
D
K
V
R
V
K
W
P
N
D
L
Y
L
Q
D
R
K
L
A
G
I
L
V
E
L
T
---D
A
A
Q
-
I
V
I
G
A
G
I
N
M
A
M
-------
G
W
I
T
L
Q
E
A
G
I
N
L
-
D
R
N
T
L
A
A
M
L
I
R
E
L
R
A
A
L
E
L
F
E
Q
E
G
L
A
P
Y
L
S
R
W
E
K
L
D
N
F
-
I
N
R
P
V
K
L
-
I
I
G
D
K
E
I
F
G
I
S
R
G
I
D
K
Q
G
A
L
L
L
E
Q
D
G
--------------
18
PsiBlast_PDB
55.03
33%
-97
- C5 -
1HXD
1
BIRA_ECOLI
A:
[65-304]
------------------
Q
L
L
N
A
K
Q
I
L
G
Q
L
D
G
G
S
V
A
V
L
P
V
I
D
S
T
N
Q
Y
L
L
D
R
I
--
G
E
L
K
S
G
D
A
C
I
A
E
Y
Q
Q
A
G
R
G
R
R
G
R
K
W
F
S
P
F
G
A
N
L
Y
L
S
M
F
W
R
L
E
Q
G
P
A
A
A
I
G
-
L
S
L
V
I
G
I
V
M
A
E
V
L
R
K
L
G
A
---
D
K
V
R
V
K
W
P
N
D
L
Y
L
Q
D
R
K
L
A
G
I
L
V
E
L
T
G
K
T
G
D
A
A
Q
I
V
I
G
A
G
I
N
M
A
M
------
Q
G
W
I
T
L
Q
E
A
G
I
N
L
-
D
R
N
T
L
A
A
M
L
I
R
E
L
R
A
A
L
E
L
F
E
Q
E
G
L
A
P
Y
L
S
R
W
E
K
L
D
N
F
-
I
N
R
P
V
K
L
-
I
I
G
D
K
E
I
F
G
I
S
R
G
I
D
K
Q
G
A
L
L
L
E
Q
D
G
--------------
35
PsiBlast_CBE
54.71
33%
-99
- C5 -
1BIB
1
BIRA_ECOLI
A:
[65-304]
------------------
Q
L
L
N
A
K
Q
I
L
G
Q
L
D
G
G
S
V
A
V
L
P
V
I
D
S
T
N
Q
Y
L
L
D
R
I
--
G
E
L
K
S
G
D
A
C
I
A
E
Y
Q
Q
A
G
R
G
R
------
S
P
F
G
A
N
L
Y
L
S
M
F
W
R
L
E
Q
-
P
A
A
A
I
G
-
L
S
L
V
I
G
I
V
M
A
E
V
L
R
K
L
G
A
---
D
K
V
R
V
K
W
P
N
D
L
Y
L
Q
D
R
K
L
A
G
I
L
V
E
L
T
G
--A
A
Q
--
I
V
I
G
A
G
I
N
M
A
M
--------
W
I
T
L
Q
E
A
G
I
N
L
-
D
R
N
T
L
A
A
M
L
I
R
E
L
R
A
A
L
E
L
F
E
Q
E
G
L
A
P
Y
L
S
R
W
E
K
L
D
N
F
-
I
N
R
P
V
K
L
-
I
I
G
D
K
E
I
F
G
I
S
R
G
I
D
K
Q
G
A
L
L
L
E
Q
D
G
--------------
34
PsiBlast_CBE
54.31
33%
-93
- C5 -
1HXD
1
BIRA_ECOLI
B:
[65-304]
------------------
Q
L
L
N
A
K
Q
I
L
G
Q
L
D
GGSVA
V
L
P
V
I
D
S
T
N
Q
Y
L
L
D
R
I
--
G
E
L
K
S
G
D
A
C
I
A
E
Y
Q
Q
A
G
R
G
R
R
G
R
K
W
F
S
P
F
G
A
N
L
Y
L
S
M
F
W
R
L
E
Q
G
P
A
A
A
I
G
-
L
S
L
V
I
G
I
V
M
A
E
V
L
R
K
L
G
A
---
D
K
V
R
V
K
W
P
N
D
L
Y
L
Q
D
R
K
L
A
G
I
L
V
E
L
T
G
K
T
GDAAQ
I
V
I
G
A
G
I
N
M
A
M
------
Q
G
W
I
T
L
Q
E
A
G
I
N
L
-
D
R
N
T
L
A
A
M
L
I
R
E
L
R
A
AL
E
L
F
E
Q
E
G
L
A
P
Y
L
S
R
W
E
K
L
D
N
F
-
I
N
R
P
V
K
L
-
I
I
G
D
K
E
I
F
G
I
S
R
G
I
D
K
Q
G
A
L
L
L
E
Q
D
G
--------------