@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3283: (2016-05-18 )
MPLPADPSPTLSAYAHPERLVTADWLSAHMGAPGLAIVESDEDVLLYDVGHIPGAVKIDWHTDLNDPRVRDYINGEQFAELMDRKGIARDDTVVIYGDKSNWWAAYALWVFTLFGHADVRLLNGGRDLWLAERRETTLDVPTKTCTGYPVVQRNDAPIRAFRDDVLAILGAQPLIDVRSPEEYTGKRTHMPDYPEEGALRAGHIPTAVHIPWGKAADESGRFRSREELERLYDFINPDDQTVVYCRIGERSSHTWFVLTHLLGKADVRNYDGSWTEWGNAVRVPIVAGEEPGVVPVV
Atome Classification :
(20 SA)
.........10........20.....-...30----.----.--......40-------..-------..--------....50---------......--...-60.--.....--..70....-....------80........90.....--.--..100.........110.......120.......----130.......140.......150---.........160.......--170--.---..--....180.......190.......200.......210.......----------220.......-230.--.--....--.--240.......250.......260........270.......280.......290.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPLPADPSPTLSAYAHP
E
R
L
V
T
A
D
W
L
-
S
A
HMG----A----P--
G
L
A
I
V
ESD-------E
D
-------
V
L
--------
L
Y
DVG----------HIP
G
A
V
--
K
I
D
-
W
HT--DLN
D
P
--
R
V
R
D
YI
N
G
-
E
Q
F
A
------
E
L
M
D
RKGIARD
D
T
V
V
I
Y
--G--DKS--
N
W
W
A
A
Y
A
L
W
V
F
T
L
FGHA
D
V
R
L
LNGG
R
D
L
W
----
L
AERRETTLDVPTKTCTGYP
V
-----
V
QRNDA
P
I
R
A
F
R
D
D
V
L
A
I
L--GAQ--P---
L
I
--DVR
S
P
E
E
YTGKRTHMPDYPEEGALRAGHI
P
T
A
V
HIPWGKAADES----------GRFR
S
R
E
E
L
E
-
R
L
Y
D
--F--INPD--D--
Q
T
V
V
Y
C
RIGERSSH
T
W
F
V
L
T
H
-
L
LGKADVRNYDGSWTEWG
N
A
V
R
V
P
I
V
AGEEPGVVPVV
22
HHSearch
97.68
100%
-100
- C2 -
3HZU
2
THT2_MYCTU
A:
[24-315]
--
L
P
A
D
P
S
P
T
L
S
A
Y
A
H
P
E
R
L
V
T
A
D
W
L
-
S
A
H
M
G
----
A
----
P
--
G
L
A
I
V
E
S
D
-------
E
D
-------
V
L
--------
L
Y
D
V
G
----------
H
I
P
G
A
V
--
K
I
D
-
W
H
T
--
D
L
N
D
P
--
R
V
R
D
Y
I
N
G
-
E
Q
F
A
------
E
L
M
D
R
K
G
I
A
R
D
D
T
V
V
I
Y
--
G
--
D
K
S
--
N
W
W
A
A
Y
A
L
W
V
F
T
L
F
G
H
A
D
V
R
L
L
N
G
G
R
D
L
W
----
L
A
E
R
R
E
T
T
L
D
V
P
T
K
T
C
T
G
Y
P
V
-----
V
Q
R
N
D
A
P
I
R
A
F
R
D
D
V
L
A
I
L
--
G
A
Q
--
P
---
L
I
--
D
V
R
S
P
E
E
Y
T
G
K
R
T
H
M
P
D
Y
P
E
E
G
A
L
R
A
G
H
I
P
T
A
V
H
I
P
W
G
K
A
A
D
E
S
----------
G
R
F
R
S
R
E
E
L
E
-
R
L
Y
D
--
F
--
I
N
P
D
--
D
--
Q
T
V
V
Y
C
R
I
G
E
R
S
S
H
T
W
F
V
L
T
H
-
L
L
G
K
A
D
V
R
N
Y
D
G
S
W
T
E
W
G
N
A
V
R
V
P
I
V
A
G
E
E
P
G
V
V
---
1
PsiBlast_PDB
97.68
100%
-100
- C2 -
3HZU
2
THT2_MYCTU
A:
[24-315]
--
L
P
A
D
P
S
P
T
L
S
A
Y
A
H
P
E
R
L
V
T
A
D
W
L
-
S
A
H
M
G
----
A
----
P
--
G
L
A
I
V
E
S
D
-------
E
D
-------
V
L
--------
L
Y
D
V
G
----------
H
I
P
G
A
V
--
K
I
D
-
W
H
T
--
D
L
N
D
P
--
R
V
R
D
Y
I
N
G
-
E
Q
F
A
------
E
L
M
D
R
K
G
I
A
R
D
D
T
V
V
I
Y
--
G
--
D
K
S
--
N
W
W
A
A
Y
A
L
W
V
F
T
L
F
G
H
A
D
V
R
L
L
N
G
G
R
D
L
W
----
L
A
E
R
R
E
T
T
L
D
V
P
T
K
T
C
T
G
Y
P
V
-----
V
Q
R
N
D
A
P
I
R
A
F
R
D
D
V
L
A
I
L
--
G
A
Q
--
P
---
L
I
--
D
V
R
S
P
E
E
Y
T
G
K
R
T
H
M
P
D
Y
P
E
E
G
A
L
R
A
G
H
I
P
T
A
V
H
I
P
W
G
K
A
A
D
E
S
----------
G
R
F
R
S
R
E
E
L
E
-
R
L
Y
D
--
F
--
I
N
P
D
--
D
--
Q
T
V
V
Y
C
R
I
G
E
R
S
S
H
T
W
F
V
L
T
H
-
L
L
G
K
A
D
V
R
N
Y
D
G
S
W
T
E
W
G
N
A
V
R
V
P
I
V
A
G
E
E
P
G
V
V
---
2
PsiBlast_PDB
88.85
79%
-94
- C2 -
3P3A
-
?
A:
[4-296]
--
L
P
A
D
P
S
P
E
L
K
Q
Y
A
H
P
E
R
L
V
T
A
D
W
L
-
A
S
N
L
G
----
R
----
P
--
G
L
V
I
V
E
S
D
-------
E
D
-------
V
L
--------
L
Y
D
T
G
----------
H
I
P
G
A
V
--
K
I
D
-
W
H
T
--
D
L
N
D
P
--
A
V
R
D
Y
I
N
G
-
E
Q
F
A
------
A
L
M
D
R
K
G
V
T
R
D
D
T
V
V
I
Y
--
G
--
D
K
S
--
N
W
W
A
A
Y
A
M
W
V
F
H
L
F
G
H
P
D
V
R
L
L
D
G
G
R
D
L
W
----
V
S
T
G
R
D
T
T
L
E
V
P
T
R
Q
T
S
G
Y
P
V
-----
V
E
R
N
D
A
P
I
R
A
F
K
D
D
V
L
R
V
L
--
G
K
E
--
P
---
L
I
--
D
V
R
S
P
Q
E
Y
T
G
E
R
T
-----
P
E
E
G
A
L
R
G
G
H
I
P
T
A
V
S
V
P
W
S
K
A
A
Y
D
D
----------
G
R
F
R
A
R
A
E
L
E
-
E
I
Y
G
--
F
--
V
K
P
D
--
D
--
K
P
I
V
Y
C
R
I
G
E
R
S
S
H
T
W
F
V
L
T
Y
-
L
L
G
H
P
N
V
R
N
Y
D
G
S
W
T
E
W
G
N
A
V
R
V
P
I
V
V
G
P
E
P
G
E
A
P
--
21
PsiBlast_CBE
77.25
49%
-90
- C2 -
3AAY
4
THTR_MYCTU
B:
[2-276]
--------------
A
R
C
D
V
L
V
S
A
D
W
A
-
E
S
N
L
H
----
A
----
P
--
K
V
V
F
V
E
V
D
-------
E
D
-------
T
S
--------
A
Y
D
R
D
----------
H
I
A
G
A
I
--
K
L
D
-
W
R
T
--
D
L
Q
D
P
--
V
K
R
D
F
V
D
A
-
Q
Q
F
S
------
K
L
L
S
E
R
G
I
A
N
E
D
T
V
I
L
Y
--
G
--
G
N
N
--
N
W
F
A
A
Y
A
Y
W
Y
F
K
L
Y
G
H
E
K
V
K
L
L
D
G
G
R
K
K
W
----
E
L
D
G
R
P
L
S
S
D
P
V
S
R
P
V
T
S
Y
-
T
-----
A
S
P
P
D
N
T
I
R
A
F
R
D
E
V
L
A
A
I
--
N
V
K
--
N
---
L
I
--
D
V
R
S
P
D
E
F
S
G
K
I
L
A
P
A
H
L
P
Q
E
Q
S
Q
R
P
G
H
I
P
G
A
I
N
V
P
W
S
R
A
A
N
E
D
----------
G
T
F
K
S
D
E
E
L
A
-
K
L
Y
A
--
D
--
A
G
L
D
--
N
S
K
E
T
I
A
Y
C
R
I
G
E
R
S
S
H
T
W
F
V
L
R
E
-
L
L
G
H
Q
N
V
K
N
Y
D
G
S
W
T
E
Y
G
S
L
V
G
A
P
I
E
L
G
---------
23
HHSearch
76.97
49%
-95
- C2 -
3AAY
4
THTR_MYCTU
A:
[4-275]
----------------
C
D
V
L
V
S
A
D
W
A
-
E
S
N
L
H
----
A
----
P
--
K
V
V
F
V
E
V
D
E------
D
--------
T
S
--------
A
Y
D
R
D
----------
H
I
A
G
A
I
--
K
L
D
-
W
R
T
--
D
L
Q
D
P
--
V
K
R
D
F
V
D
A
-
Q
Q
F
S
------
K
L
L
S
E
R
G
I
A
N
E
D
T
V
I
L
Y
--
G
--
G
N
N
--
N
W
F
A
A
Y
A
Y
W
Y
F
K
L
Y
G
H
E
K
V
K
L
L
D
G
G
R
K
K
W
----
E
L
D
G
R
P
L
S
S
D
P
V
S
R
P
V
T
S
Y
T
A
-----
S
-
P
P
D
N
T
I
R
A
F
R
D
E
V
L
A
A
I
--
N
V
K
--
N
---
L
I
--
D
V
R
S
P
D
E
F
S
G
K
I
L
A
-----
Q
E
Q
S
Q
R
P
G
H
I
P
G
A
I
N
V
P
W
S
R
A
A
N
E
D
----------
G
T
F
K
S
D
E
E
L
A
-
K
L
Y
A
--
D
A
G
L
D
N
S
--
K
--
E
T
I
A
Y
C
R
I
G
E
R
S
S
H
T
W
F
V
L
-
R
E
L
L
G
H
Q
N
V
K
N
Y
D
G
S
W
T
E
Y
G
S
L
V
G
A
P
I
E
L
----------
5
PsiBlast_PDB
76.31
49%
-91
- C2 -
3AAY
4
THTR_MYCTU
A:
[2-276]
--------------
A
R
C
D
V
L
V
S
A
D
W
A
-
E
S
N
L
H
----
A
----
P
--
K
V
V
F
V
E
V
D
-------
E
D
-------
T
S
--------
A
Y
D
R
D
----------
H
I
A
G
A
I
--
K
L
D
-
W
R
T
--
D
L
Q
D
P
--
V
K
R
D
F
V
D
A
-
Q
Q
F
S
------
K
L
L
S
E
R
G
I
A
N
E
D
T
V
I
L
Y
--
G
--
G
N
N
--
N
W
F
A
A
Y
A
Y
W
Y
F
K
L
Y
G
H
E
K
V
K
L
L
D
G
G
R
K
K
W
----
E
L
D
G
R
P
L
S
S
D
P
V
S
R
P
V
T
S
Y
-
T
-----
A
S
P
P
D
N
T
I
R
A
F
R
D
E
V
L
A
A
I
--
N
V
K
--
N
---
L
I
--
D
V
R
S
P
D
E
F
S
G
K
I
L
A
-----
Q
E
Q
S
Q
R
P
G
H
I
P
G
A
I
N
V
P
W
S
R
A
A
N
E
D
----------
G
T
F
K
S
D
E
E
L
A
-
K
L
Y
A
--
D
--
A
G
L
D
--
N
S
K
E
T
I
A
Y
C
R
I
G
E
R
S
S
H
T
W
F
V
L
R
E
-
L
L
G
H
Q
N
V
K
N
Y
D
G
S
W
T
E
Y
G
S
L
V
G
A
P
I
E
L
G
---------
3
PsiBlast_PDB
76.02
49%
-92
- C2 -
3HWI
-
THTR_MYCTU
A:
[3-276]
---------------
R
C
D
V
L
V
S
A
D
W
A
-
E
S
N
L
H
----
A
----
P
--
K
V
V
F
V
E
V
D
-------
E
D
-------
T
S
--------
A
Y
D
R
D
----------
H
I
A
G
A
I
--
K
L
D
-
W
R
T
--
D
L
Q
D
P
--
V
K
R
D
F
V
D
A
-
Q
Q
F
S
------
K
L
L
S
E
R
G
I
A
N
E
D
T
V
I
L
Y
--
G
--
G
N
N
--
N
W
F
A
A
Y
A
Y
W
Y
F
K
L
Y
G
H
E
K
V
K
L
L
D
G
G
R
K
K
W
----
E
L
D
G
R
P
L
S
S
D
P
V
S
R
P
V
T
S
Y
-
T
-----
A
S
P
P
D
N
T
I
R
A
F
R
D
E
V
L
A
A
I
--
N
V
K
--
N
---
L
I
--
D
V
R
S
P
D
E
F
S
G
K
I
L
A
P
--------
Q
R
P
G
H
I
P
G
A
I
N
V
P
W
S
R
A
A
N
E
D
----------
G
T
F
K
S
D
E
E
L
A
-
K
L
Y
A
--
D
--
A
G
L
D
--
N
S
K
E
T
I
A
Y
C
R
I
G
E
R
S
S
H
T
W
F
V
L
R
E
-
L
L
G
H
Q
N
V
K
N
Y
D
G
S
W
T
E
Y
G
S
L
V
G
A
P
I
E
L
G
---------
4
PsiBlast_PDB
75.02
49%
-91
- C2 -
3AAX
-
THTR_MYCTU
A:
[4-276]
----------------
C
D
V
L
V
S
A
D
W
A
-
E
S
N
L
H
----
A
----
P
--
K
V
V
F
V
E
V
D
-------
E
D
-------
T
S
--------
A
Y
D
R
D
----------
H
I
A
G
A
I
--
K
L
D
-
W
R
T
--
D
L
Q
D
P
--
V
K
R
D
F
V
D
A
-
Q
Q
F
S
------
K
L
L
S
E
R
G
I
A
N
E
D
T
V
I
L
Y
--
G
--
G
N
N
--
N
W
F
A
A
Y
A
Y
W
Y
F
K
L
Y
G
H
E
K
V
K
L
L
D
G
G
R
K
K
W
----
E
L
D
G
R
P
L
S
S
D
P
V
S
R
P
V
T
S
Y
-
T
-----
A
S
P
P
D
N
T
I
R
A
F
R
D
E
V
L
A
A
I
--
N
V
K
--
N
---
L
I
--
D
V
R
S
P
D
E
F
S
G
K
I
L
A
P
A
H
L
--
E
Q
S
Q
R
P
G
H
I
P
G
A
I
N
V
P
W
S
R
A
A
N
E
D
----------
G
T
F
K
S
D
E
E
L
A
-
K
L
Y
A
--
D
--
A
G
L
D
--
N
S
K
E
T
I
A
Y
C
R
I
G
E
R
S
S
H
T
W
F
V
L
R
E
-
L
L
G
H
Q
N
V
K
N
Y
D
G
S
W
T
E
Y
G
S
L
V
G
A
P
I
E
L
G
---------
26
HHSearch
66.79
28%
-82
- C2 -
1RHS
-
THTR_BOVIN
A:
[6-286]
----------------
Y
R
A
L
V
S
T
K
W
L
-
A
E
S
V
R
A
GKV
G
----
P
--
G
L
R
V
L
D
A
S
-------
W
Y
S
P
GTRE
A
R
K
--------
E
Y
L
E
R
----------
H
V
P
G
A
S
--
F
F
D
-
I
E
E
--
C
R
D
K
A
SP
Y
E
V
M
L
P
S
E
-
A
G
F
A
------
D
Y
V
G
S
L
G
I
S
N
D
T
H
V
V
V
Y
--
D
--
G
D
D
LG
S
F
Y
A
P
R
V
W
W
M
F
R
V
F
G
H
R
T
V
S
V
L
N
G
G
F
R
N
W
----
L
K
E
G
H
P
V
T
S
E
P
S
R
P
E
P
A
I
F
K
A
-------
T
L
N
R
S
L
L
K
T
Y
E
Q
V
L
E
N
L
E
S
K
R
F
--
Q
---
L
V
--
D
S
R
A
Q
G
R
Y
L
G
T
Q
P
E
----
P
D
A
V
G
L
D
S
G
H
I
R
G
S
V
N
M
P
F
M
N
F
L
T
E
D
----------
G
F
E
K
S
P
E
E
L
R
-
A
M
F
E
--
A
K
K
V
D
L
T
--
K
--
P
L
I
A
T
-
R
K
G
V
T
A
C
H
I
A
L
A
A
-
Y
-
L
C
G
K
P
D
V
A
I
Y
D
G
S
W
F
E
W
F
H
R
-
A
P
P
E
T
-----------
14
PsiBlast_PDB
66.48
28%
-82
- C2 -
1RHS
-
THTR_BOVIN
A:
[9-278]
-------------------
L
V
S
T
K
W
L
-
A
E
S
V
R
----
A
GKVG
P
--
G
L
R
V
L
D
A
S
W
Y
S
P
GTR
E
A
-------
R
K
--------
E
Y
L
E
R
----------
H
V
P
G
A
S
--
F
F
D
-
I
E
E
CR
D
K
A
S
P
--
Y
E
V
M
L
P
S
E
-
A
G
F
A
------
D
Y
V
G
S
L
G
I
S
N
D
T
H
V
V
V
Y
--
D
GD
D
L
G
--
S
F
Y
A
P
R
V
W
W
M
F
R
V
F
G
H
R
T
V
S
V
L
N
G
G
F
R
N
W
----
L
K
E
G
H
P
V
T
S
E
-
P
S
R
P
E
P
A
I
F
K
-----
A
T
L
N
R
S
L
L
K
T
Y
-
E
Q
V
L
E
N
L
--
E
S
K
R
F
Q
---
L
V
--
D
S
R
A
Q
G
R
Y
L
G
T
Q
P
E
----
P
D
A
V
G
L
D
S
G
H
I
R
G
S
V
N
M
P
F
M
N
F
L
T
E
D
----------
G
F
E
K
S
P
E
E
L
R
-
A
M
F
E
--
A
--
K
K
V
D
LT
K
--
P
L
I
A
T
-
R
K
G
V
T
A
C
H
I
-
A
L
A
A
Y
-
L
C
G
K
P
D
V
A
I
Y
D
G
S
W
F
E
W
--------------------
8
PsiBlast_PDB
65.26
29%
-83
- C2 -
1ORB
1
THTR_BOVIN
A:
[9-278]
-------------------
L
V
S
T
K
W
L
-
A
E
S
V
R
----
A
GKVG
P
--
G
L
R
V
L
D
A
S
WYSPGTR
E
A
-------
R
K
--------
E
Y
L
E
R
----------
H
V
P
G
A
S
--
F
F
D
-
I
E
E
CR
D
K
A
S
P
--
Y
E
V
M
L
P
S
E
-
A
G
F
A
------
D
Y
V
G
S
L
G
I
S
N
D
T
H
V
V
V
Y
--
D
GD
D
L
G
--
S
F
Y
A
P
R
V
W
W
M
F
R
V
F
G
H
R
T
V
S
V
L
N
G
G
F
R
N
W
----
L
K
E
G
H
P
V
T
S
E
-
P
S
R
P
E
P
A
I
F
K
-----
A
T
L
N
R
S
L
L
K
T
Y
-
E
Q
V
L
E
N
L
--
E
S
K
R
F
Q
---
L
V
--
D
S
R
A
Q
G
R
Y
L
G
T
Q
P
E
----
P
D
A
V
G
L
D
S
G
H
I
R
G
S
V
N
M
P
F
M
N
F
L
T
E
D
----------
G
F
E
K
S
P
E
E
L
R
-
A
M
F
E
--
A
--
K
K
V
D
LT
K
--
P
L
I
A
T
C
R
K
G
V
T
A
C
H
I
-
A
L
A
A
Y
-
L
C
G
K
P
D
V
A
I
Y
D
G
S
W
F
E
W
--------------------
11
PsiBlast_PDB
65.04
28%
-83
- C2 -
1BOH
-
THTR_BOVIN
A:
[9-278]
-------------------
L
V
S
T
K
W
L
-
A
E
S
V
R
----
A
GKVG
P
--
G
L
R
V
L
D
A
S
W
Y
S
PGTR
E
A
-------
R
K
--------
E
Y
L
E
R
----------
H
V
P
G
A
S
--
F
F
D
-
I
E
E
CR
D
K
A
S
P
--
Y
E
V
M
L
P
S
E
-
A
G
F
A
------
D
Y
V
G
S
L
G
I
S
N
D
T
H
V
V
V
Y
--
D
GD
D
L
G
--
S
F
Y
A
P
R
V
W
W
M
F
R
V
F
G
H
R
T
V
S
V
L
N
G
G
F
R
N
W
----
L
K
E
G
H
P
V
T
S
E
-
P
S
R
P
E
P
A
I
F
K
-----
A
T
L
N
R
S
L
L
K
T
Y
-
E
Q
V
L
E
N
L
--
E
S
K
R
F
Q
---
L
V
--
D
S
R
A
Q
G
R
Y
L
G
T
Q
P
E
----
P
D
A
V
G
L
D
S
G
H
I
R
G
S
V
N
M
P
F
M
N
F
L
T
E
D
----------
G
F
E
K
S
P
E
E
L
R
-
A
M
F
E
--
A
--
K
K
V
D
LT
K
--
P
L
I
A
T
-
R
K
G
V
T
A
C
H
I
-
A
L
A
A
Y
-
L
C
G
K
P
D
V
A
I
Y
D
G
S
W
F
E
W
--------------------
12
PsiBlast_PDB
64.72
28%
-83
- C2 -
1BOI
-
THTR_BOVIN
A:
[9-278]
-------------------
L
V
S
T
K
W
L
-
A
E
S
V
R
----
A
GKVG
P
--
G
L
R
V
L
D
A
S
W
Y
S
PGTR
E
A
-------
R
K
--------
E
Y
L
E
R
----------
H
V
P
G
A
S
--
F
F
D
-
I
E
E
CR
D
K
A
S
P
--
Y
E
V
M
L
P
S
E
-
A
G
F
A
------
D
Y
V
G
S
L
G
I
S
N
D
T
H
V
V
V
Y
--
D
GD
D
L
G
--
S
F
Y
A
P
R
V
W
W
M
F
R
V
F
G
H
R
T
V
S
V
L
N
G
G
F
R
N
W
----
L
K
E
G
H
P
V
T
S
E
-
P
S
R
P
E
P
A
I
F
K
-----
A
T
L
N
R
S
L
L
K
T
Y
-
E
Q
V
L
E
N
L
--
E
S
K
R
F
Q
---
L
V
--
D
S
R
A
Q
G
R
Y
L
G
T
Q
P
E
----
P
D
A
V
G
L
D
S
G
H
I
R
G
S
V
N
M
P
F
M
N
F
L
T
E
D
----------
G
F
E
K
S
P
E
E
L
R
-
A
M
F
E
--
A
--
K
K
V
D
LT
K
--
P
L
I
A
T
-
R
K
G
V
T
A
C
H
I
-
A
L
A
A
Y
-
L
C
G
K
P
D
V
A
I
Y
D
G
S
W
F
E
W
--------------------
9
PsiBlast_PDB
64.62
28%
-85
- C2 -
1RHD
1
THTR_BOVIN
A:
[9-278]
-------------------
L
V
S
T
K
W
L
-
A
E
S
V
R
----
A
GKVG
P
--
G
L
R
V
L
D
A
S
W
Y
S
PGTR
E
A
-------
R
K
--------
E
Y
L
E
R
----------
H
V
P
G
A
S
--
F
F
D
-
I
E
E
CR
D
K
A
S
P
--
Y
E
V
M
L
P
S
E
-
A
G
F
A
------
D
Y
V
G
S
L
G
I
S
N
D
T
H
V
V
V
Y
--
N
GD
D
L
G
--
S
F
Y
A
P
R
V
W
W
M
F
R
V
F
G
H
R
T
V
S
V
L
N
G
G
F
R
N
W
----
L
K
E
G
H
P
V
T
S
E
-
P
S
R
P
E
P
A
I
F
K
-----
A
T
L
N
R
S
L
L
K
T
Y
-
E
Q
V
L
E
N
L
--
E
S
K
R
F
Q
---
L
V
--
D
S
R
A
Q
G
R
Y
L
G
T
Q
P
E
----
P
D
A
V
G
L
D
S
G
H
I
R
G
S
V
N
M
P
F
M
D
F
L
T
E
N
----------
G
F
E
K
S
P
E
E
L
R
-
A
M
F
E
--
A
--
K
K
V
D
LT
K
--
P
L
I
A
T
C
R
K
G
V
T
A
C
H
I
-
A
L
A
A
Y
-
L
C
G
K
P
D
V
A
I
Y
D
G
S
W
F
E
W
--------------------
6
PsiBlast_PDB
64.61
34%
-78
- C2 -
1H4K
5
THTR_AZOVI
X:
[16-269]
-------------------------
L
-
Q
A
R
L
S
----
A
----
P
--
E
L
I
L
V
D
L
T
--------
S
-------
A
A
--------
R
Y
A
E
G
----------
H
I
P
G
A
R
--
F
V
D
P
K
R
T
--
Q
L
G
Q
P
--
P
A
P
G
L
Q
P
P
R
E
Q
L
E
------
S
L
F
G
E
L
G
H
R
P
E
A
V
Y
V
V
Y
--
D
--
D
E
G
--
G
G
W
A
G
R
F
I
W
L
L
D
V
I
G
Q
Q
R
Y
H
Y
L
N
G
G
L
T
A
W
----
L
A
E
D
R
P
L
S
R
E
L
P
A
P
--
A
G
G
P
V
A----
L
S
L
H
D
E
P
T
-
A
S
R
D
Y
L
L
G
R
L
--
G
A
A
--
D
---
L
A
IW
D
A
R
S
P
Q
E
Y
R
G
E
K
V
L
--------
A
A
K
G
G
H
I
P
G
A
V
N
F
E
W
T
A
A
M
D
P
S
----------
R
A
L
R
I
R
T
D
I
A
G
R
L
E
E
--
L
G-
I
T
P
D
--
K
--
E
I
V
T
H
C
Q
T
H
H
R
S
G
L
T
-
Y
L
I
A
K
-
A
L
G
Y
P
R
V
K
G
Y
A
G
S
W
G
E
W
G
N
H
P
D
T
P
V
------------
10
PsiBlast_PDB
62.47
28%
-80
- C2 -
3OLH
3
THTM_HUMAN
A:
[21-292]
-----------------
Q
S
M
V
S
A
Q
W
V
-
A
E
A
L
R
----
A
----
P
RA
G
Q
P
L
Q
L
L
D
-------
A
S
-------
W
Y
--------
L
P
K
--RD
A
R
R
E
F
E
E
R
H
I
P
G
A
A
F
F
D
I
D
-
Q
C
S
--
D
R
T
S
P
--
Y
D
H
M
L
P
G
A
-
E
H
F
A
------
E
Y
A
G
R
L
G
V
G
A
A
T
H
V
V
I
Y
D
A
S
--
D
Q
G
--
L
Y
S
A
P
R
V
W
W
M
F
R
A
F
G
H
H
A
V
S
L
L
D
G
G
L
R
H
W
----
L
R
Q
------
N
L
P
-
S
S
G
K
S
Q
P
A
P
A
E
F
R
A
Q
L
D
P
A
F
I
K
T
Y
-
E
D
I
K
E
N
L
--
E
S
R
R
F
Q
---
V
V
--
D
S
R
A
T
G
R
F
R
G
T
E
P
E
----
P
R
D
G
-
I
E
P
G
H
I
P
G
T
V
N
I
P
F
T
D
F
L
S
Q
E
----------
G
L
E
K
S
P
E
E
I
R
-
H
L
F
Q
E
K
K
--
V
D
L
S
--
K
--
P
L
V
A
T
C
G
S
G
V
T
A
C
H
V
-
A
L
G
A
Y
-
L
C
G
K
P
D
V
P
I
Y
D
G
S
W
V
E
W
--------------------
7
PsiBlast_PDB
62.27
34%
-76
- C2 -
1H4M
2
THTR_AZOVI
X:
[16-269]
-------------------------
L
-
Q
A
R
L
S
----
A
----
P
--
E
L
I
L
V
D
L
T
--------
S
-------
A
A
--------
R
Y
A
E
G
----------
H
I
P
G
A
R
--
F
V
D
P
K
R
T
--
Q
L
G
Q
P
--
P
A
P
G
L
Q
P
P
R
E
Q
L
E
------
S
L
F
G
E
L
G
H
R
P
E
A
V
Y
V
V
Y
--
D
--
D
E
G
--
G
G
W
A
G
R
F
I
W
L
L
D
V
I
G
Q
Q
R
Y
H
Y
L
N
G
G
L
T
A
W
----
L
A
E
D
R
P
L
S
R
E
L
P
A
P
--
A
G
G
P
V
A----
L
S
L
H
D
E
P
T
-
A
S
R
D
Y
L
L
G
R
L
--
G
A
A
--
D
---
L
A
IW
D
A
R
S
P
Q
E
Y
R
G
E
K
V
L
--------
A
A
K
G
G
H
I
P
G
A
V
N
F
E
W
T
A
A
M
D
P
S
----------
R
A
L
R
I
R
T
D
I
A
G
R
L
E
E
--
L
G-
I
T
P
D
--
K
--
E
I
V
T
H
C
Q
T
H
H
R
S
G
L
T
-
Y
L
I
A
K
-
A
L
G
Y
P
R
V
K
G
Y
A
G
S
W
G
E
W
G
N
H
P
D
T
P
V
------------
13
PsiBlast_PDB
62.18
28%
-77
- C2 -
2ORA
-
THTR_BOVIN
A:
[9-278]
-------------------
L
V
S
T
K
W
L
-
A
E
S
V
R
----
A
GKVG
P
--
G
L
R
V
L
D
A
S
WYSPGTR
E
A
-------
R
K
--------
E
Y
L
E
R
----------
H
V
P
G
A
S
--
F
F
D
-
I
E
E
CR
D
K
A
S
P
--
Y
E
V
M
L
P
S
E
-
A
G
F
A
------
D
Y
V
G
S
L
G
I
S
N
D
T
H
V
V
V
Y
--
D
GD
D
L
G
--
S
F
Y
A
P
R
V
W
W
M
F
R
V
F
G
H
R
T
V
S
V
L
N
G
G
F
R
N
W
----
L
K
E
G
H
P
V
T
S
E
-
P
S
R
P
E
P
A
I
F
K
-----
A
T
L
N
R
S
L
L
K
T
Y
-
E
Q
V
L
E
N
L
--
E
S
K
R
F
Q
---
L
V
--
D
S
R
A
Q
G
R
Y
L
G
T
Q
P
E
----
P
D
A
V
G
L
D
S
G
H
I
R
G
S
V
N
M
P
F
M
N
F
L
T
E
D
----------
G
F
E
K
S
P
E
E
L
R
-
A
M
F
E
--
A
--
K
K
V
D
LT
K
--
P
L
I
A
T
C
R
K
G
V
T
A
C
H
I
-
A
L
A
A
Y
-
L
C
G
K
P
D
V
A
I
Y
D
G
S
W
F
E
W
--------------------
15
PsiBlast_PDB
62.04
26%
-70
- C2 -
3IPP
5
YNJE_ECOLI
A:
[117-410]
----------
L
Q
K
L
P
H
F
E
Q
L
V
Y
P
Q
W
L
H
D
L
Q
Q
G
----
K
----
E
--
V
T
A
K
P
A
G
D
-------
W
K
-------
V
I
E
A
A
W
G
AP
K
L
Y
L
I
S
----------
H
I
P
G
A
D
--
Y
I
D
-
T
N
E
--
V
E
S
E
P
---
L
W
N
K
V
S
D
-
E
Q
L
K
------
A
M
L
A
K
H
G
I
R
H
D
T
T
V
I
L
Y
--
G
---
R
D
--
V
Y
A
A
A
R
V
A
Q
I
M
L
Y
A
G
V
K
D
V
R
L
L
D
G
G
W
Q
T
W
S
D
A
G
L
P
V
E
R
G
T
P
P
K
V
K
A
E
P
D
F
G
V
K
I
-----
P
A
Q
P
Q
L
M
L
D
M
E
Q
A
R
G
L
L
H
R
--
Q
D
A
--
S
---
L
V
--
S
I
R
S
W
P
E
F
I
G
T
T
S
G
Y
S
Y
I
K
P
K
G
E
I
A
G
A
R
--------
W
G
H
A
G
S
D
S
THMEDFHNPD
G
T
M
R
S
A
D
D
I
T
-
A
M
W
K
--
A
W
N
I
K
P
E
--
Q
--
Q
V
S
F
Y
C
G
T
G
W
R
A
S
E
T
-
F
M
Y
A
R
-
A
M
G
W
K
N
V
S
V
Y
D
G
G
W
Y
E
W
S
S
D
P
K
N
P
V
A
T
G
E
--------
16
PsiBlast_PDB
55.06
31%
-82
- C2 -
2EG4
6
?
A:
[18-221]
-------------------------------------------------------------------------------
Y
E
A
G
----------
H
L
P
G
A
-------
R
H
L
--
D
L
S
A
P
--
K
L
R
L
R
E
E
A
-
E
L
K
A
L
E
G
G
L
T
E
L
F
Q
T
L
G
L
--
R
S
P
V
V
L
Y
-----
D
E
G
--
L
T
S
R
L
C
R
T
A
F
F
L
G
L
G
G
L
E
V
Q
L
W
T
E
G
W
E
P
Y
----
A
T
E
K
E
E
-------------
P
K
-----
P
E
R
T
E
V
V
A
K
L
R
R
D
W
L
L
T
A
D
--
E
A
A
--
R
HPL
L
L
--
D
V
R
S
P
E
E
F
Q
G
K
-
V
H
P
P
C
C
P
-----
R
G
G
R
I
P
G
S
K
N
A
P
L
E
L
F
L
S
P
E
----------
G
L
------
L
E
-
R
L
G
------
L
Q
P
G
--
Q
--
E
V
G
V
Y
C
H
S
G
A
R
S
A
V
A
F
F
V
L
R
S
-
L
G
V
R
A
--
R
N
Y
L
G
S
M
H
E
W
--------------------