@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3313c: (2016-05-18 )
MTAAPTLQTIRLAPKALLHDHLDGGLRPATVLDIAGQVGYDDLPATDVDALASWFRTQSHSGSLERYLEPFSHTVAVMQTPEALYRVAFECAQDLAADSVVYAEVRFAPELHISCGLSFDDVVDTVLTGFAAGEKACAADGQPITVRCLVTAMRHAAMSREIAELAIRFRDKGVVGFDIAGAEAGHPPTRHLDAFEYMRDHNARFTIHAGEAFGLPSIHEAIAFCGADRLGHGVRIVDDIDVDADGGFQLGRLAAILRDKRIPLELCPSSNVQTGAVASIAEHPFDLLARARFRVTVNTDNRLMSDTSMSLEMHRLVEAFGYGWSDLARFTVNAMKSAFIPFDQRLAIIDEVIKPRFAALMGHSE
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70....-.-...-80........90........100.......110-----------..------------......120.......130.......140.......150...-.-..-.160.......170.......180.....---..---190-.........200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTAAPT
L
Q
T
IRLA
P
K
A
L
L
H
D
HLDGGLR
P
A
T
V
L
DIAGQVGYDDLPAT
D
V
D
A
L
A
S
W
F
RTQSHS
G
S
L
E
R
Y
L
E
P
F
SH
T
V
-
A
-
V
MQ-
T
P
E
A
L
Y
R
V
A
F
E
C
A
Q
D
LAAD
S
V
V
Y
A
E
V
R
FA
P
E
L
------------
H
I
------------SCGL
S
F
D
D
V
V
D
T
V
L
T
G
F
AAGEKACAADGQ
P
I
T
V
R
C
L
V
T
A
M
R
H
-
A
-
A
M
-
S
R
E
I
A
E
L
A
I
R
F
RDK
G
V
V
G
F
DIAGAEAGHP---PT---R---
H
L
D
A
F
E
Y
M
R
DHN
A
R
F
T
I
HAGEAFGL
P
S
I
H
E
A
I
A
F
C
G
A
D
RLGH
G
V
R
I
V
D
D
I
DVDADGGF
Q
L
G
R
L
A
A
I
L
RDKRI
P
L
E
LCPSSNVQTG
A
V
A
S
I
A
EH
P
F
D
L
L
AR
A
R
F
R
V
T
VNTDNRLMSDTS
M
S
L
E
M
H
R
L
V
E
A
FGY
G
W
S
D
L
A
R
F
T
V
N
A
M
K
S
AFI
P
F
D
Q
R
L
A
I
I
D
E
V
I
K
P
R
F
A
A
L
MGHSE
43
Fugue
94.34
30%
-96
- C3 -
1A4M
2
ADA_MOUSE
A:
[1-349]
-------
T
P
A
F
N
K
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
F
G
K
K
R
G
I
A
-
L
P
A
D
T
V
E
E
L
R
N
I
I
G
M
D
K
P
L
-
S
L
P
G
F
L
A
K
F
D
Y
Y
M
-
P
-
V
I
A
G
C
R
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
L
LANSKVDPMPWN
Q
T
------------
E
G
D
V
T
P
D
D
V
V
D
L
V
N
Q
G
L
Q
E
G
E
Q
A
F
-----
G
I
K
V
R
S
I
L
C
C
M
R
H
Q
P
-
S
W
-
S
L
E
V
L
E
L
C
K
K
Y
N
Q
K
T
V
V
A
M
D
L
A
G
D
E
T
I
E
G
---
S
S
LF
P
G
---
H
V
E
A
Y
E
G
A
V
K
N
G
I
H
R
T
V
H
A
G
E
V
G
S
P
E
V
V
R
E
A
V
D
I
L
K
T
E
R
V
G
H
G
Y
H
T
I
E
D
-----------
E
A
L
Y
N
R
L
L
K
E
N
M
H
F
E
V
C
P
W
S
S
Y
L
T
G
A
W
D
P
K
T
T
H
A
V
V
R
F
K
N
D
K
A
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
E
E
E
K
K
E
L
L
E
R
L
Y
R
E
Y
Q
--------
13
PsiBlast_PDB
94.00
27%
-103
- C3 -
2Z7G
2
ADA_BOVIN
A:
[9-348]
-------------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
Y
G
K
R
R
G
I
A
-
L
P
A
D
T
P
E
E
L
Q
N
I
I
-
G
M
D
K
P
L
T
L
P
D
F
L
A
K
F
D
Y
Y
M
P
A
-
I
A
G
-
C
R
D
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
D
G
V
V
Y
V
E
V
R
Y
S
P
H
L
LANSKVEPIPWN
Q
A
------------
E
G
D
L
T
P
D
E
V
V
S
L
V
N
Q
G
L
Q
E
G
E
R
D
F
G
-----
V
K
V
R
S
I
L
C
C
M
R
H
-
Q
P
S
W
-
S
S
E
V
V
E
L
C
K
K
Y
R
E
Q
T
V
V
A
I
D
L
A
G
D
E
T
I
E
G
---
S
S
---
L
F
P
G
H
V
Q
A
Y
A
E
A
V
K
S
G
V
H
R
T
V
H
A
G
E
V
G
S
A
N
V
V
K
E
A
V
D
T
L
K
T
E
R
L
G
H
G
Y
H
T
L
E
D
T
-----------
T
L
Y
N
R
L
R
Q
E
N
M
H
F
E
I
C
P
W
S
S
Y
L
T
G
A
W
K
P
D
T
E
H
A
V
I
R
F
K
N
D
Q
V
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
E
D
E
K
K
E
L
L
D
L
L
Y
K
-----------
21
HHSearch
93.33
29%
-92
- C3 -
3IAR
5
ADA_HUMAN
A:
[3-354]
---------
A
F
D
K
P
K
V
E
L
H
V
H
L
D
G
S
I
K
P
E
T
I
L
Y
Y
G
R
R
R
G
I
A
-
L
P
A
N
T
A
E
G
L
L
N
V
I
G
-
M
D
K
P
L
T
L
P
D
F
L
A
K
F
D
Y
Y
M
-
P
A
I
A
G
-
C
R
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
L
------------
L
A
NSKVEPIPWNQA
E
G
D
L
T
P
D
E
V
V
A
L
V
G
Q
G
L
Q
E
G
E
R
-----
D
F
G
V
K
A
R
S
I
L
C
C
M
R
H
-
Q
-
P
N
W
S
P
K
V
V
E
L
C
K
K
Y
Q
Q
Q
T
V
V
A
I
D
L
A
G
D
E
T
I
P
G
SSL
L
P
---
G
---
H
V
Q
A
Y
Q
E
A
V
K
S
G
I
H
R
T
V
H
A
G
E
V
G
S
A
E
V
V
K
E
A
V
D
I
L
K
T
E
R
L
G
H
G
Y
H
T
L
E
D
Q
A
-----------
L
Y
N
R
L
R
Q
E
N
M
H
F
E
I
C
P
W
S
S
Y
L
T
G
A
W
K
P
D
T
E
H
A
V
I
R
L
K
N
D
Q
A
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
R
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
E
D
E
K
R
E
L
L
D
L
-
L
Y
K
A
Y
G
M
P
P
S
A
--
8
PsiBlast_PDB
93.22
27%
-101
- C3 -
1V7A
2
ADA_BOVIN
A:
[9-348]
-------------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
Y
G
K
R
R
G
I
A
-
L
P
A
D
T
P
E
E
L
Q
N
I
I
-
G
M
D
K
P
L
T
L
P
D
F
L
A
K
F
D
Y
Y
M
P
A
-
I
A
G
-
C
R
D
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
D
G
V
V
Y
V
E
V
R
Y
S
P
H
L
LANSKVEPIPWN
Q
A
------------
E
G
D
L
T
P
D
E
V
V
S
L
V
N
Q
G
L
Q
E
G
E
R
D
F
G
-----
V
K
V
R
S
I
L
C
C
M
R
H
-
Q
P
S
W
-
S
S
E
V
V
E
L
C
K
K
Y
R
E
Q
T
V
V
A
I
D
L
A
G
D
E
T
I
E
G
---
S
S
---
L
F
P
G
H
V
Q
A
Y
A
E
A
V
K
S
G
V
H
R
T
V
H
A
G
E
V
G
S
A
N
V
V
K
E
A
V
D
T
L
K
T
E
R
L
G
H
G
Y
H
T
L
E
D
T
-----------
T
L
Y
N
R
L
R
Q
E
N
M
H
F
E
I
C
P
W
S
S
Y
L
T
G
A
W
K
P
D
T
E
H
A
V
I
R
F
K
N
D
Q
V
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
E
D
E
K
K
E
L
L
D
L
L
Y
K
-----------
9
PsiBlast_PDB
93.21
27%
-101
- C3 -
1VFL
1
ADA_BOVIN
A:
[9-348]
-------------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
Y
G
K
R
R
G
I
A
-
L
P
A
D
T
P
E
E
L
Q
N
I
I
-
G
M
D
K
P
L
T
L
P
D
F
L
A
K
F
D
Y
Y
M
P
A
-
I
A
G
-
C
R
D
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
D
G
V
V
Y
V
E
V
R
Y
S
P
H
L
LANSKVEPIPWN
Q
A
------------
E
G
D
L
T
P
D
E
V
V
S
L
V
N
Q
G
L
Q
E
G
E
R
D
F
G
-----
V
K
V
R
S
I
L
C
C
M
R
H
-
Q
P
S
W
-
S
S
E
V
V
E
L
C
K
K
Y
R
E
Q
T
V
V
A
I
D
L
A
G
D
E
T
I
E
G
---
S
S
---
L
F
P
G
H
V
Q
A
Y
A
E
A
V
K
S
G
V
H
R
T
V
H
A
G
E
V
G
S
A
N
V
V
K
E
A
V
D
T
L
K
T
E
R
L
G
H
G
Y
H
T
L
E
D
T
-----------
T
L
Y
N
R
L
R
Q
E
N
M
H
F
E
I
C
P
W
S
S
Y
L
T
G
A
W
K
P
D
T
E
H
A
V
I
R
F
K
N
D
Q
V
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
E
D
E
K
K
E
L
L
D
L
L
Y
K
-----------
3
PsiBlast_PDB
93.21
27%
-101
- C3 -
1NDY
2
ADA_BOVIN
A:
[9-348]
-------------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
Y
G
K
R
R
G
I
A
-
L
P
A
D
T
P
E
E
L
Q
N
I
I
-
G
M
D
K
P
L
T
L
P
D
F
L
A
K
F
D
Y
Y
M
P
A
-
I
A
G
-
C
R
D
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
D
G
V
V
Y
V
E
V
R
Y
S
P
H
L
LANSKVEPIPWN
Q
A
------------
E
G
D
L
T
P
D
E
V
V
S
L
V
N
Q
G
L
Q
E
G
E
R
D
F
G
-----
V
K
V
R
S
I
L
C
C
M
R
H
-
Q
P
S
W
-
S
S
E
V
V
E
L
C
K
K
Y
R
E
Q
T
V
V
A
I
D
L
A
G
D
E
T
I
E
G
---
S
S
---
L
F
P
G
H
V
Q
A
Y
A
E
A
V
K
S
G
V
H
R
T
V
H
A
G
E
V
G
S
A
N
V
V
K
E
A
V
D
T
L
K
T
E
R
L
G
H
G
Y
H
T
L
E
D
T
-----------
T
L
Y
N
R
L
R
Q
E
N
M
H
F
E
I
C
P
W
S
S
Y
L
T
G
A
W
K
P
D
T
E
H
A
V
I
R
F
K
N
D
Q
V
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
E
D
E
K
K
E
L
L
D
L
L
Y
K
-----------
7
PsiBlast_PDB
93.11
27%
-102
- C3 -
1V79
2
ADA_BOVIN
A:
[9-348]
-------------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
Y
G
K
R
R
G
I
A
-
L
P
A
D
T
P
E
E
L
Q
N
I
I
-
G
M
D
K
P
L
T
L
P
D
F
L
A
K
F
D
Y
Y
M
P
A
-
I
A
G
-
C
R
D
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
D
G
V
V
Y
V
E
V
R
Y
S
P
H
L
LANSKVEPIPWN
Q
A
------------
E
G
D
L
T
P
D
E
V
V
S
L
V
N
Q
G
L
Q
E
G
E
R
D
F
G
-----
V
K
V
R
S
I
L
C
C
M
R
H
-
Q
P
S
W
-
S
S
E
V
V
E
L
C
K
K
Y
R
E
Q
T
V
V
A
I
D
L
A
G
D
E
T
I
E
G
---
S
S
---
L
F
P
G
H
V
Q
A
Y
A
E
A
V
K
S
G
V
H
R
T
V
H
A
G
E
V
G
S
A
N
V
V
K
E
A
V
D
T
L
K
T
E
R
L
G
H
G
Y
H
T
L
E
D
T
-----------
T
L
Y
N
R
L
R
Q
E
N
M
H
F
E
I
C
P
W
S
S
Y
L
T
G
A
W
K
P
D
T
E
H
A
V
I
R
F
K
N
D
Q
V
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
E
D
E
K
K
E
L
L
D
L
L
Y
K
-----------
6
PsiBlast_PDB
93.00
27%
-103
- C3 -
1UML
2
ADA_BOVIN
A:
[9-348]
-------------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
Y
G
K
R
R
G
I
A
-
L
P
A
D
T
P
E
E
L
Q
N
I
I
-
G
M
D
K
P
L
T
L
P
D
F
L
A
K
F
D
Y
Y
M
P
A
-
I
A
G
-
C
R
D
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
D
G
V
V
Y
V
E
V
R
Y
S
P
H
L
LANSKVEPIPWN
Q
A
------------
E
G
D
L
T
P
D
E
V
V
S
L
V
N
Q
G
L
Q
E
G
E
R
D
F
G
-----
V
K
V
R
S
I
L
C
C
M
R
H
-
Q
P
S
W
-
S
S
E
V
V
E
L
C
K
K
Y
R
E
Q
T
V
V
A
I
D
L
A
G
D
E
T
I
E
G
---
S
S
---
L
F
P
G
H
V
Q
A
Y
A
E
A
V
K
S
G
V
H
R
T
V
H
A
G
E
V
G
S
A
N
V
V
K
E
A
V
D
T
L
K
T
E
R
L
G
H
G
Y
H
T
L
E
D
T
-----------
T
L
Y
N
R
L
R
Q
E
N
M
H
F
E
I
C
P
W
S
S
Y
L
T
G
A
W
K
P
D
T
E
H
A
V
I
R
F
K
N
D
Q
V
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
E
D
E
K
K
E
L
L
D
L
L
Y
K
-----------
14
PsiBlast_PDB
92.72
27%
-99
- C3 -
1W1I
1
ADA_BOVIN
E:
[10-349]
-------------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
Y
G
K
R
R
G
I
A
-
L
P
A
D
T
P
E
E
L
L
N
I
I
-
G
M
D
K
P
L
T
L
P
D
F
L
A
K
F
D
Y
Y
M
P
A
-
I
A
G
-
C
R
D
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
D
G
V
V
Y
V
E
V
R
Y
S
P
H
L
LANSKVEPIPWN
Q
A
------------
E
G
D
L
T
P
D
E
V
V
S
L
V
N
Q
G
L
Q
E
G
E
R
D
F
G
-----
V
K
V
R
S
I
L
C
C
M
R
H
-
Q
P
S
W
-
S
S
E
V
V
E
L
C
K
K
Y
R
E
Q
T
V
V
A
I
D
L
A
G
D
E
T
I
E
G
---
S
S
---
L
FPG
H
V
Q
A
Y
A
E
A
V
K
S
G
V
H
R
T
V
H
A
G
E
V
G
S
A
N
V
V
K
E
A
V
D
T
L
K
T
E
R
L
G
H
G
Y
H
T
L
E
D
T
-----------
T
L
Y
N
R
L
R
Q
E
N
M
H
F
E
I
C
P
W
S
S
Y
L
T
G
A
W
K
P
D
T
E
H
A
V
I
R
F
K
N
D
Q
V
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
E
D
E
K
K
E
L
L
D
L
L
Y
K
-----------
17
PsiBlast_PDB
92.33
27%
-99
- C3 -
2BGN
1
ADA_BOVIN
E:
[10-349]
-------------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
Y
G
K
R
R
G
I
A
-
L
P
A
D
T
P
E
E
L
L
N
I
I
-
G
M
D
K
P
L
T
L
P
D
F
L
A
K
F
D
Y
Y
M
P
A
-
I
A
G
-
C
R
D
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
D
G
V
V
Y
V
E
V
R
Y
S
P
H
L
LANSKVEPIPWN
Q
A
------------
E
G
D
L
T
P
D
E
V
V
S
L
V
N
Q
G
L
Q
E
G
E
R
D
F
G
-----
V
K
V
R
S
I
L
C
C
M
R
H
-
Q
P
S
W
-
S
S
E
V
V
E
L
C
K
K
Y
R
E
Q
T
V
V
A
I
D
L
A
G
D
E
T
I
E
G
---
S
S
---
L
FPG
H
V
Q
A
Y
A
E
A
V
K
S
G
V
H
R
T
V
H
A
G
E
V
G
S
A
N
V
V
K
E
A
V
D
T
L
K
T
E
R
L
G
H
G
Y
H
T
L
E
D
T
-----------
T
L
Y
N
R
L
R
Q
E
N
M
H
F
E
I
C
P
W
S
S
Y
L
T
G
A
W
K
P
D
T
E
H
A
V
I
R
F
K
N
D
Q
V
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
E
D
E
K
K
E
L
L
D
L
L
Y
K
-----------
11
PsiBlast_PDB
92.29
27%
-100
- C3 -
1WXZ
2
ADA_BOVIN
A:
[9-348]
-------------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
Y
G
K
R
R
G
I
A
-
L
P
A
D
T
P
E
E
L
Q
N
I
I
-
G
M
D
K
P
L
T
L
P
D
F
L
A
K
F
D
Y
Y
M
P
A
-
I
A
G
-
C
R
D
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
D
G
V
V
Y
V
E
V
R
Y
S
P
H
L
LANSKVEPIPWN
Q
A
------------
E
G
D
L
T
P
D
E
V
V
S
L
V
N
Q
G
L
Q
E
G
E
R
D
F
G
-----
V
K
V
R
S
I
L
C
C
M
R
H
-
Q
P
S
W
-
S
S
E
V
V
E
L
C
K
K
Y
R
E
Q
T
V
V
A
I
D
L
A
G
D
E
T
I
E
G
---
S
S
---
L
F
P
G
H
V
Q
A
Y
A
E
A
V
K
S
G
V
H
R
T
V
H
A
G
E
V
G
S
A
N
V
V
K
E
A
V
D
T
L
K
T
E
R
L
G
H
G
Y
H
T
L
E
D
T
-----------
T
L
Y
N
R
L
R
Q
E
N
M
H
F
E
I
C
P
W
S
S
Y
L
T
G
A
W
K
P
D
T
E
H
A
V
I
R
F
K
N
D
Q
V
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
E
D
E
K
K
E
L
L
D
L
L
Y
K
-----------
4
PsiBlast_PDB
92.17
27%
-103
- C3 -
1NDZ
2
ADA_BOVIN
A:
[9-348]
-------------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
Y
G
K
R
R
G
I
A
-
L
P
A
D
T
P
E
E
L
Q
N
I
I
-
G
M
D
K
P
L
T
L
P
D
F
L
A
K
F
D
Y
Y
M
P
A
-
I
A
G
-
C
R
D
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
D
G
V
V
Y
V
E
V
R
Y
S
P
H
L
LANSKVEPIPWN
Q
A
------------
E
G
D
L
T
P
D
E
V
V
S
L
V
N
Q
G
L
Q
E
G
E
R
D
F
G
-----
V
K
V
R
S
I
L
C
C
M
R
H
-
Q
P
S
W
-
S
S
E
V
V
E
L
C
K
K
Y
R
E
Q
T
V
V
A
I
D
L
A
G
D
E
T
I
E
G
---
S
S
---
L
F
P
G
H
V
Q
A
Y
A
E
A
V
K
S
G
V
H
R
T
V
H
A
G
E
V
G
S
A
N
V
V
K
E
A
V
D
T
L
K
T
E
R
L
G
H
G
Y
H
T
L
E
D
T
-----------
T
L
Y
N
R
L
R
Q
E
N
M
H
F
E
I
C
P
W
S
S
Y
L
T
G
A
W
K
P
D
T
E
H
A
V
I
R
F
K
N
D
Q
V
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
E
D
E
K
K
E
L
L
D
L
L
Y
K
-----------
2
PsiBlast_PDB
92.16
27%
-100
- C3 -
1NDW
2
ADA_BOVIN
A:
[9-348]
-------------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
Y
G
K
R
R
G
I
A
-
L
P
A
D
T
P
E
E
L
Q
N
I
I
-
G
M
D
K
P
L
T
L
P
D
F
L
A
K
F
D
Y
Y
M
P
A
-
I
A
G
-
C
R
D
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
D
G
V
V
Y
V
E
V
R
Y
S
P
H
L
LANSKVEPIPWN
Q
A
------------
E
G
D
L
T
P
D
E
V
V
S
L
V
N
Q
G
L
Q
E
G
E
R
D
F
G
-----
V
K
V
R
S
I
L
C
C
M
R
H
-
Q
P
S
W
-
S
S
E
V
V
E
L
C
K
K
Y
R
E
Q
T
V
V
A
I
D
L
A
G
D
E
T
I
E
G
---
S
S
---
L
F
P
G
H
V
Q
A
Y
A
E
A
V
K
S
G
V
H
R
T
V
H
A
G
E
V
G
S
A
N
V
V
K
E
A
V
D
T
L
K
T
E
R
L
G
H
G
Y
H
T
L
E
D
T
-----------
T
L
Y
N
R
L
R
Q
E
N
M
H
F
E
I
C
P
W
S
S
Y
L
T
G
A
W
K
P
D
T
E
H
A
V
I
R
F
K
N
D
Q
V
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
E
D
E
K
K
E
L
L
D
L
L
Y
K
-----------
10
PsiBlast_PDB
91.88
27%
-99
- C3 -
1WXY
2
ADA_BOVIN
A:
[9-348]
-------------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
Y
G
K
R
R
G
I
A
-
L
P
A
D
T
P
E
E
L
Q
N
I
I
-
G
M
D
K
P
L
T
L
P
D
F
L
A
K
F
D
Y
Y
M
P
A
-
I
A
G
-
C
R
D
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
D
G
V
V
Y
V
E
V
R
Y
S
P
H
L
LANSKVEPIPWN
Q
A
------------
E
G
D
L
T
P
D
E
V
V
S
L
V
N
Q
G
L
Q
E
G
E
R
D
F
G
-----
V
K
V
R
S
I
L
C
C
M
R
H
-
Q
P
S
W
-
S
S
E
V
V
E
L
C
K
K
Y
R
E
Q
T
V
V
A
I
D
L
A
G
D
E
T
I
E
G
---
S
S
---
L
F
P
G
H
V
Q
A
Y
A
E
A
V
K
S
G
V
H
R
T
V
H
A
G
E
V
G
S
A
N
V
V
K
E
A
V
D
T
L
K
T
E
R
L
G
H
G
Y
H
T
L
E
D
T
-----------
T
L
Y
N
R
L
R
Q
E
N
M
H
F
E
I
C
P
W
S
S
Y
L
T
G
A
W
K
P
D
T
E
H
A
V
I
R
F
K
N
D
Q
V
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
E
D
E
K
K
E
L
L
D
L
L
Y
K
-----------
16
PsiBlast_PDB
91.69
27%
-102
- C3 -
1QXL
2
ADA_BOVIN
A:
[9-348]
-------------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
Y
G
K
R
R
G
I
A
-
L
P
A
D
T
P
E
E
L
L
N
I
I
-
G
M
D
K
P
L
T
L
P
D
F
L
A
K
F
D
Y
Y
M
P
A
-
I
A
G
-
C
R
D
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
D
G
V
V
Y
V
E
V
R
Y
S
P
H
L
LANSKVEPIPWN
Q
A
------------
E
G
D
L
T
P
D
E
V
V
S
L
V
N
Q
G
L
Q
E
G
E
R
D
F
G
-----
V
K
V
R
S
I
L
C
C
M
R
H
-
Q
P
S
W
-
S
S
E
V
V
E
L
C
K
K
Y
R
E
Q
T
V
V
A
I
D
L
A
G
D
E
T
I
E
G
---
S
S
---
L
F
P
G
H
V
Q
A
Y
A
E
A
V
K
S
G
V
H
R
T
V
H
A
G
E
V
G
S
A
N
V
V
K
E
A
V
D
T
L
K
T
E
R
L
G
H
G
Y
H
T
L
E
D
T
-----------
T
L
Y
N
R
L
R
Q
E
N
M
H
F
E
I
C
P
W
S
S
Y
L
T
G
A
W
K
P
D
T
E
H
A
V
I
R
F
K
N
D
Q
V
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
E
D
E
K
K
E
L
L
D
L
L
Y
K
-----------
1
PsiBlast_PDB
91.44
27%
-101
- C3 -
1NDV
2
ADA_BOVIN
A:
[9-348]
-------------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
Y
G
K
R
R
G
I
A
-
L
P
A
D
T
P
E
E
L
Q
N
I
I
-
G
M
D
K
P
L
T
L
P
D
F
L
A
K
F
D
Y
Y
M
P
A
-
I
A
G
-
C
R
D
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
D
G
V
V
Y
V
E
V
R
Y
S
P
H
L
LANSKVEPIPWN
Q
A
------------
E
G
D
L
T
P
D
E
V
V
S
L
V
N
Q
G
L
Q
E
G
E
R
D
F
G
-----
V
K
V
R
S
I
L
C
C
M
R
H
-
Q
P
S
W
-
S
S
E
V
V
E
L
C
K
K
Y
R
E
Q
T
V
V
A
I
D
L
A
G
D
E
T
I
E
G
---
S
S
---
L
F
P
G
H
V
Q
A
Y
A
E
A
V
K
S
G
V
H
R
T
V
H
A
G
E
V
G
S
A
N
V
V
K
E
A
V
D
T
L
K
T
E
R
L
G
H
G
Y
H
T
L
E
D
T
-----------
T
L
Y
N
R
L
R
Q
E
N
M
H
F
E
I
C
P
W
S
S
Y
L
T
G
A
W
K
P
D
T
E
H
A
V
I
R
F
K
N
D
Q
V
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
E
D
E
K
K
E
L
L
D
L
L
Y
K
-----------
12
PsiBlast_PDB
91.35
27%
-99
- C3 -
2E1W
2
ADA_BOVIN
A:
[9-348]
-------------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
Y
G
K
R
R
G
I
A
-
L
P
A
D
T
P
E
E
L
Q
N
I
I
-
G
M
D
K
P
L
T
L
P
D
F
L
A
K
F
D
Y
Y
M
P
A
-
I
A
G
-
C
R
D
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
D
G
V
V
Y
V
E
V
R
Y
S
P
H
L
LANSKVEPIPWN
Q
A
------------
E
G
D
L
T
P
D
E
V
V
S
L
V
N
Q
G
L
Q
E
G
E
R
D
F
G
-----
V
K
V
R
S
I
L
C
C
M
R
H
-
Q
P
S
W
-
S
S
E
V
V
E
L
C
K
K
Y
R
E
Q
T
V
V
A
I
D
L
A
G
D
E
T
I
E
G
---
S
S
---
L
F
P
G
H
V
Q
A
Y
A
E
A
V
K
S
G
V
H
R
T
V
H
A
G
E
V
G
S
A
N
V
V
K
E
A
V
D
T
L
K
T
E
R
L
G
H
G
Y
H
T
L
E
D
T
-----------
T
L
Y
N
R
L
R
Q
E
N
M
H
F
E
I
C
P
W
S
S
Y
L
T
G
A
W
K
P
D
T
E
H
A
V
I
R
F
K
N
D
Q
V
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
E
D
E
K
K
E
L
L
D
L
L
Y
K
-----------
15
PsiBlast_PDB
90.38
27%
-97
- C3 -
1KRM
2
ADA_BOVIN
A:
[9-348]
-------------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
Y
G
K
R
R
G
I
A
-
L
P
A
D
T
P
E
E
L
L
N
I
I
-
G
M
D
K
P
L
T
L
P
D
F
L
A
K
F
D
Y
Y
M
P
A
-
I
A
G
-
C
R
D
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
D
G
V
V
Y
V
E
V
R
Y
S
P
H
L
LANSKVEPIPWN
Q
A
------------
E
G
D
L
T
P
D
E
V
V
S
L
V
N
Q
G
L
Q
E
G
E
R
D
F
G
-----
V
K
V
R
S
I
L
C
C
M
R
H
-
Q
P
S
W
-
S
S
E
V
V
E
L
C
K
K
Y
R
E
Q
T
V
V
A
I
D
L
A
G
D
E
T
I
E
G
---
S
S
---
L
F
P
G
H
V
Q
A
Y
A
E
A
V
K
S
G
V
H
R
T
V
H
A
G
E
V
G
S
A
N
V
V
K
E
A
V
D
T
L
K
T
E
R
L
G
H
G
Y
H
T
L
E
D
T
-----------
T
L
Y
N
R
L
R
Q
E
N
M
H
F
E
I
C
P
W
S
S
Y
L
T
G
A
W
K
P
D
T
E
H
A
V
I
R
F
K
N
D
Q
V
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
E
D
E
K
K
E
L
L
D
L
L
Y
K
-----------
5
PsiBlast_PDB
90.11
27%
-101
- C3 -
1O5R
2
ADA_BOVIN
A:
[9-348]
-------------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
Y
G
K
R
R
G
I
A
-
L
P
A
D
T
P
E
E
L
Q
N
I
I
-
G
M
D
K
P
L
T
L
P
D
F
L
A
K
F
D
Y
Y
M
P
A
-
I
A
G
-
C
R
D
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
D
G
V
V
Y
V
E
V
R
Y
S
P
H
L
LANSKVEPIPWN
Q
A
------------
E
G
D
L
T
P
D
E
V
V
S
L
V
N
Q
G
L
Q
E
G
E
R
D
F
G
-----
V
K
V
R
S
I
L
C
C
M
R
H
-
Q
P
S
W
-
S
S
E
V
V
E
L
C
K
K
Y
R
E
Q
T
V
V
A
I
D
L
A
G
D
E
T
I
E
G
---
S
S
---
L
F
P
G
H
V
Q
A
Y
A
E
A
V
K
S
G
V
H
R
T
V
H
A
G
E
V
G
S
A
N
V
V
K
E
A
V
D
T
L
K
T
E
R
L
G
H
G
Y
H
T
L
E
D
T
-----------
T
L
Y
N
R
L
R
Q
E
N
M
H
F
E
I
C
P
W
S
S
Y
L
T
G
A
W
K
P
D
T
E
H
A
V
I
R
F
K
N
D
Q
V
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
E
D
E
K
K
E
L
L
D
L
L
Y
K
-----------
20
PsiBlast_PDB
90.01
28%
-99
- C3 -
1A4M
2
ADA_MOUSE
A:
[7-333]
-------------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
F
G
K
K
R
G
I
A
-
L
P
A
D
T
V
E
E
L
R
N
I
I
-
G
M
D
K
P
L
S
L
P
G
F
L
A
K
F
D
Y
Y
M
-
P
-
V
I
A
G
C
R
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
L
LANSKVDPMPWN
Q
T
------------
E
G
D
V
T
P
D
D
V
V
D
L
V
N
Q
G
L
Q
E
G
E
Q
A
F
G
-----
I
K
V
R
S
I
L
C
C
M
R
H
-
Q
P
S
W
-
S
L
E
V
L
E
L
C
K
K
Y
N
Q
K
T
V
V
A
M
D
L
A
G
D
E
T
I
E
G
---
S
S
---
L
F
P
G
H
V
E
A
Y
E
G
A
V
K
N
G
I
H
R
T
V
H
A
G
E
V
G
S
P
E
V
V
R
E
A
V
D
I
L
K
T
E
R
V
G
H
G
Y
H
T
I
E
D
-----------
E
A
L
Y
N
R
L
L
K
E
N
M
H
F
E
V
C
P
W
S
S
Y
L
T
G
A
W
D
P
K
T
T
H
A
V
V
R
F
K
N
D
K
A
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
------------------------