@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3382c: (2016-05-19 )
MAEVFVGPVAQGYASGEVTVLLASPRSFCAGVERAIETVKRVLDVAEGPVYVRKQIVHNTVVVAELRDRGAVFVEDLDEIPDPPPPGAVVVFSAHGVSPAVRAGADERGLQVVDATCPLVAKVHAEAARFAARGDTVVFIGHAGHEETEGTLGVAPRSTLLVQTPADVAALNLPEGTQLSYLTQTTLALDETADVIDALRARFPTLGQPPSEDICYATTNRQRALQSMVGECDVVLVIGSCNSSNSRRLVELAQRSGTPAYLIDGPDDIEPEWLSSVSTIGVTAGASAPPRLVGQVIDALRGYASITVVERSIATETVRFGLPKQVRAQ
Atome Classification :
(60 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.....---..160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300...-....310......-.320.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAE
V
F
VG
P
V
AQGYASG
E
V
T
V
L
LAS
P
R
S
F
C
A
G
V
E
R
A
I
E
T
V
K
R
V
L
D
VAEG
P
V
Y
V
R
K
Q
I
VHN
T
V
V
V
A
ELRDRGA
V
F
V
E
D
L
D
EIPDPPPP
G
A
V
V
V
F
SAHGV
S
P
A
V
RAGADERG
L
Q
V
VDATC
P
L
V
A
K
V
H
A
E
A
A
R
FAARG
D
T
V
V
F
I
GHAGHEETEGTLGVAPR---
S
T
L
L
V
QTPAD
V
A
A
LNLPEGT
Q
L
S
Y
L
T
Q
T
T
LAL
D
E
T
A
D
V
I
D
A
L
R
A
RFPTLGQPPSED
I
C
Y
ATT
N
R
Q
R
A
L
Q
S
M
VGEC
D
V
V
L
V
I
GSCNSSN
S
R
R
L
V
E
L
A
Q
RSGT
P
A
Y
L
IDGPDDI
E
P
E
W
L
S
SVS
T
I
G
VTAGASA
P
P
R
L
V
G
Q
V
I
D
A
L
RGY
A
S
-
I
T
V
V
E
RSIA
T
E
T
V
-RFGL
P
K
Q
VRAQ
29
PsiBlast_CBE
90.01
50%
-120
- C8 -
4MV0
2
?
B:
[13-321]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PEG
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
26
PsiBlast_CBE
89.91
50%
-119
- C8 -
3UTC
2
ISPH_ECOLI
B:
[9-317]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PEG
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
37
PsiBlast_CBE
89.89
50%
-118
- C8 -
4H4D
2
ISPH_ECOLI
B:
[9-317]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PEG
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
20
PsiBlast_PDB
89.83
50%
-119
- C8 -
3T0F
2
ISPH_ECOLI
A:
[11-321]
---------------
G
S
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
D
V
E
G
T
M
G
Q
Y
S
N
PE
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
2
PsiBlast_PDB
89.75
50%
-118
- C8 -
3UTC
2
ISPH_ECOLI
A:
[9-317]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PE
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
22
PsiBlast_CBE
89.70
50%
-117
- C8 -
3UV7
2
ISPH_ECOLI
B:
[9-317]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PEG
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
25
PsiBlast_CBE
89.66
50%
-118
- C8 -
3UTD
2
ISPH_ECOLI
B:
[9-317]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PEG
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
30
PsiBlast_CBE
89.64
50%
-118
- C8 -
4MUY
2
?
B:
[13-321]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PEG
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
28
PsiBlast_CBE
89.62
50%
-119
- C8 -
4MV5
2
?
B:
[13-321]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PEG
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
32
PsiBlast_CBE
89.55
50%
-119
- C8 -
4EB3
2
ISPH_ECOLI
B:
[13-321]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PEG
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
12
PsiBlast_PDB
89.52
50%
-119
- C8 -
4MV5
2
?
A:
[13-321]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PE
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
8
PsiBlast_PDB
89.49
50%
-117
- C8 -
4EB3
2
ISPH_ECOLI
A:
[13-321]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PE
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
46
PsiBlast_CBE
89.40
50%
-116
- C8 -
3KEM
2
ISPH_ECOLI
A:
[11-319]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PE
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
51
PsiBlast_CBE
89.37
50%
-115
- C8 -
3KE9
2
ISPH_ECOLI
B:
[11-319]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PEG
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
23
PsiBlast_CBE
89.33
50%
-117
- C8 -
3UV6
2
ISPH_ECOLI
B:
[9-317]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PEG
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
72
HHSearch
89.31
51%
-114
- C8 -
4H4D
2
ISPH_ECOLI
A:
[9-317]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
----
D
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PE
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
45
PsiBlast_CBE
89.31
50%
-115
- C8 -
3KEM
2
ISPH_ECOLI
B:
[11-319]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PEG
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
27
PsiBlast_CBE
89.26
50%
-116
- C8 -
3URK
2
ISPH_ECOLI
B:
[9-317]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PEG
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
49
PsiBlast_CBE
89.25
50%
-116
- C8 -
3KEF
2
ISPH_ECOLI
B:
[11-319]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PEG
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
11
PsiBlast_PDB
89.24
50%
-116
- C8 -
4MUX
2
?
A:
[13-321]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PE
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
39
PsiBlast_CBE
89.18
50%
-116
- C8 -
3SZU
2
ISPH_ECOLI
B:
[13-321]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
Q
V
E
G
T
M
G
Q
Y
S
N
PEG
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
10
PsiBlast_PDB
89.18
50%
-118
- C8 -
4MV0
2
?
A:
[13-321]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PE
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
36
PsiBlast_CBE
89.10
50%
-117
- C8 -
4H4E
2
ISPH_ECOLI
B:
[9-317]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PEG
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
53
PsiBlast_CBE
89.09
50%
-116
- C8 -
3KE8
2
ISPH_ECOLI
B:
[11-319]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PEG
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
55
PsiBlast_CBE
88.96
50%
-118
- C8 -
3T0G
2
ISPH_ECOLI
B:
[13-321]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PEG
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
C
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
31
PsiBlast_CBE
88.96
50%
-116
- C8 -
4MUX
2
?
B:
[13-321]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PEG
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
13
PsiBlast_PDB
88.95
50%
-112
- C8 -
3F7T
7
ISPH_ECOLI
A:
[13-321]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PE
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
21
PsiBlast_CBE
88.93
50%
-114
- C8 -
3UWM
2
ISPH_ECOLI
B:
[9-317]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PEG
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
5
PsiBlast_PDB
88.93
50%
-116
- C8 -
3UV6
2
ISPH_ECOLI
A:
[9-317]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PE
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
47
PsiBlast_CBE
88.91
50%
-116
- C8 -
3KEL
2
ISPH_ECOLI
B:
[11-319]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PEG
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
40
PsiBlast_CBE
88.90
50%
-126
- C8 -
3T0F
2
ISPH_ECOLI
B:
[11-321]
---------------
G
S
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
------
T
M
G
Q
---G--
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
48
PsiBlast_CBE
88.86
50%
-113
- C8 -
3KEL
2
ISPH_ECOLI
A:
[11-319]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PE
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
34
PsiBlast_CBE
88.83
50%
-116
- C8 -
3SZL
2
ISPH_ECOLI
B:
[13-321]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PEG
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
43
PsiBlast_CBE
88.82
50%
-116
- C8 -
3ZGL
2
ISPH_ECOLI
B:
[17-325]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PEG
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
19
PsiBlast_PDB
88.72
50%
-114
- C8 -
3SZU
2
ISPH_ECOLI
A:
[13-321]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
Q
V
E
G
T
M
G
Q
Y
S
N
PE
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
17
PsiBlast_PDB
88.69
50%
-113
- C8 -
4H4D
2
ISPH_ECOLI
A:
[9-317]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PE
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
50
PsiBlast_CBE
88.67
50%
-113
- C8 -
3KEF
2
ISPH_ECOLI
A:
[11-319]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PE
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
1
PsiBlast_PDB
88.65
50%
-115
- C8 -
3URK
2
ISPH_ECOLI
A:
[9-317]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PE
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
35
PsiBlast_CBE
88.64
50%
-113
- C8 -
3F7T
6
ISPH_ECOLI
B:
[13-321]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PEG
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
41
PsiBlast_CBE
88.62
50%
-115
- C8 -
3ZGN
2
ISPH_ECOLI
B:
[17-325]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PEG
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
16
PsiBlast_PDB
88.58
50%
-114
- C8 -
4H4C
2
ISPH_ECOLI
A:
[9-317]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PE
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
3
PsiBlast_PDB
88.57
50%
-113
- C8 -
3UTD
2
ISPH_ECOLI
A:
[9-317]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PE
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
38
PsiBlast_CBE
88.54
50%
-114
- C8 -
4H4C
2
ISPH_ECOLI
B:
[9-317]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PEG
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
4
PsiBlast_PDB
88.53
50%
-114
- C8 -
3UV3
2
ISPH_ECOLI
A:
[9-317]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PE
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
52
PsiBlast_CBE
88.48
50%
-116
- C8 -
3KE9
2
ISPH_ECOLI
A:
[11-319]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PE
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
9
PsiBlast_PDB
88.45
50%
-115
- C8 -
4MUY
2
?
A:
[13-321]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PE
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
24
PsiBlast_CBE
88.43
50%
-116
- C8 -
3UV3
2
ISPH_ECOLI
B:
[9-317]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PEG
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
33
PsiBlast_CBE
88.37
50%
-115
- C8 -
3SZO
2
ISPH_ECOLI
B:
[13-321]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PEG
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
56
PsiBlast_CBE
88.28
50%
-116
- C8 -
3T0G
2
ISPH_ECOLI
A:
[13-321]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PE
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
C
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
7
PsiBlast_PDB
88.23
50%
-115
- C8 -
3UWM
2
ISPH_ECOLI
A:
[9-317]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PE
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
14
PsiBlast_PDB
87.98
50%
-115
- C8 -
3SZL
2
ISPH_ECOLI
A:
[13-321]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PE
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
42
PsiBlast_CBE
87.85
50%
-111
- C8 -
3ZGN
2
ISPH_ECOLI
A:
[17-325]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PE
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
54
PsiBlast_CBE
87.79
50%
-111
- C8 -
3KE8
2
ISPH_ECOLI
A:
[11-319]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PE
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
6
PsiBlast_PDB
87.74
50%
-113
- C8 -
3UV7
2
ISPH_ECOLI
A:
[9-317]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PE
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
44
PsiBlast_CBE
87.36
50%
-110
- C8 -
3ZGL
2
ISPH_ECOLI
A:
[17-325]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PE
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
18
PsiBlast_PDB
87.31
50%
-115
- C8 -
4H4E
2
ISPH_ECOLI
A:
[9-317]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PE
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
15
PsiBlast_PDB
87.12
50%
-111
- C8 -
3SZO
2
ISPH_ECOLI
A:
[13-321]
-----------------
M
Q
I
L
L
A
N
P
R
G
F
C
A
G
V
D
R
A
I
S
I
V
E
N
A
L
A
I
Y
G
A
P
I
Y
V
R
H
E
V
V
H
N
R
Y
V
V
D
S
L
R
E
R
G
A
I
F
I
E
Q
I
S
E
V
P
D
----
G
A
I
L
I
F
S
A
H
G
V
S
Q
A
V
R
N
E
A
K
S
R
D
L
T
V
F
D
A
T
C
P
L
V
T
K
V
H
M
E
V
A
R
A
S
R
R
G
E
E
S
I
L
I
G
H
A
G
H
P
E
V
E
G
T
M
G
Q
Y
S
N
PE
G
G
M
Y
L
V
E
S
P
D
D
V
W
K
L
T
V
K
N
E
E
K
L
S
F
M
T
Q
T
T
L
S
V
D
D
T
S
D
V
I
D
A
L
R
K
R
F
P
K
I
V
G
P
R
K
D
D
I
C
Y
A
T
T
N
R
Q
E
A
V
R
A
L
A
E
Q
A
E
V
V
L
V
V
G
S
K
N
S
S
N
S
N
R
L
A
E
L
A
Q
R
M
G
K
R
A
F
L
I
D
D
A
K
D
I
Q
E
E
W
V
K
E
V
K
C
V
G
V
T
A
G
A
S
A
P
D
I
L
V
Q
N
V
V
A
R
L
Q
Q
L
G
G
-
G
E
A
I
P
L
E
G
R
E
E
N
I
-
V
F
E
V
P
K
E
L
R
--
73
HHSearch
85.31
39%
-110
- C8 -
4N7B
6
?
A:
[218-529]
---------------
P
N
K
I
L
Y
L
I
N
P
R
G
F
C
K
G
V
S
R
A
I
E
T
V
E
E
C
L
K
L
F
K
P
P
I
Y
V
K
H
K
I
V
H
N
D
I
V
C
K
K
L
E
K
E
G
A
I
F
I
E
D
L
N
D
V
P
----
D
G
H
I
L
I
Y
S
A
H
G
I
S
P
Q
I
R
E
I
A
K
K
K
K
L
I
E
I
D
A
T
C
P
L
V
N
K
V
H
V
Y
V
Q
M
K
A
K
E
N
Y
D
I
I
L
I
G
Y
K
N
H
V
E
V
I
G
T
Y
N
E
A
P
H
---
C
T
H
I
V
E
N
V
N
D
V
D
K
L
N
F
P
L
N
K
K
L
F
Y
V
T
Q
T
T
L
S
M
D
D
C
A
L
I
V
Q
K
L
K
N
K
F
P
H
I
E
T
I
P
S
G
S
I
C
Y
A
T
T
N
R
Q
T
A
L
N
K
I
C
T
K
C
D
L
T
I
V
V
G
S
S
S
S
S
N
A
K
K
L
V
Y
S
S
Q
I
R
N
V
P
A
V
L
L
N
T
V
H
D
L
D
Q
Q
I
L
K
N
V
N
K
I
A
L
T
S
A
A
S
T
P
E
Q
E
T
Q
K
F
V
N
L
L
T
N
P
P
F
N
Y
T
L
Q
N
F
D
G
A
H
E
N
V
P
K
W
K
L
P
K
N
F
L
H
M
57
PsiBlast_CBE
80.06
40%
-112
- C8 -
4N7B
6
?
A:
[222-498]
-------------------
L
Y
L
I
N
P
R
G
F
C
K
G
V
S
R
A
I
E
T
V
E
E
C
L
K
L
F
K
P
P
I
Y
V
K
H
K
I
V
H
N
D
I
V
C
K
K
L
E
K
E
G
A
I
F
I
E
D
L
N
D
V
P
D
----
G
H
I
L
I
Y
S
A
H
G
I
S
P
Q
I
R
E
I
A
K
K
K
K
L
I
E
I
D
A
T
C
P
L
V
N
K
V
H
V
Y
V
Q
M
K
A
K
E
N
Y
D
I
I
L
I
G
Y
K
N
H
V
E
V
I
G
T
Y
N
E
A
P
H
---
C
T
H
I
V
E
N
V
N
D
V
D
K
L
N
F
P
L
N
K
K
L
F
Y
V
T
Q
T
T
L
S
M
D
D
C
A
L
I
V
Q
K
L
K
N
K
F
P
H
I
E
T
I
P
S
G
S
I
C
Y
A
T
T
N
R
Q
T
A
L
N
K
I
C
T
K
C
D
L
T
I
V
V
G
S
S
S
S
S
N
A
K
K
L
V
Y
S
S
Q
I
R
N
V
P
A
V
L
L
N
T
V
H
D
L
D
Q
Q
I
L
K
N
V
N
K
I
A
L
T
S
A
A
S
T
P
E
Q
E
T
Q
K
F
V
N
L
L
-------------------------------
62
Fugue
71.37
30%
-113
- C8 -
3DNF
2
ISPH_AQUAE
A:
[1-281]
----------------
M
V
D
I
I
I
A
E
H
A
G
F
C
F
G
V
K
R
A
V
K
L
A
E
E
S
L
K
E
S
Q
G
K
V
Y
T
L
G
P
I
I
H
N
P
Q
E
V
N
R
L
K
N
L
G
-
V
F
P
S
Q
G
E
E
F
K
E
----
G
D
T
V
I
I
R
S
H
G
I
P
P
E
K
E
E
A
L
R
K
K
G
L
K
V
I
D
A
T
C
P
Y
V
K
A
V
H
E
A
V
C
Q
L
T
R
E
G
Y
F
V
V
L
V
G
E
K
N
H
P
E
V
I
G
T
L
G
Y
L
R
A
C
N
G
K
G
I
V
V
E
T
L
E
D
I
G
E
A
L
K
H
E
--
R
V
G
I
V
A
Q
T
T
Q
N
E
E
F
F
K
E
V
V
G
E
I
A
L
W
V
K
E
V
K
V
I
--
N
T
I
C
N
A
T
S
L
R
Q
E
S
V
K
K
L
A
P
E
V
D
V
M
I
I
I
G
G
K
N
S
G
N
T
R
R
L
Y
Y
I
S
K
E
L
N
P
N
T
Y
H
I
E
T
A
E
E
L
Q
P
E
W
F
R
G
V
K
R
V
G
I
S
A
G
A
S
T
P
D
W
I
I
E
Q
V
K
S
R
I
Q
E
I
----------------------------