@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3394c: (2016-05-19 )
MMASARVLAIWCMDWPAVAAAAAAGLSATAPVAVTLANRVIACSATARAAGVRRGLRRREAAARCPQLFIATADADRDARLFEGVIAAVDDLVPRAELLRPGLLVLPVRGPARFFGSEQMAAERLIDAVAAAGAECQVGIADRLSTAVFAARAGRIVEPGGDARFLSLLSIRQLATEPSLSGPGRDDLTDLLWRMGIRTIGQFAALSRTDVASRFGADAVAAHRFARGEPERAPCGREPPPDLAAELACDPPIDRVDAAAFAGRSLAAELHRALMAAGVGCTRLAIHAVTANGEERSRVWRCAEPLTEDATADRVRWQLDGWLNNRNARDRPTAAVTLLRLQAVETVSASEGLQLPLWGGLGEQDRLRARRALVRVQGLLGPEAVRVPVLSGGHGPAERITLTVLGLVAPEPVPQADPGQPWPGRLPDPSPAVLFDDPVDLLDAQGNPIRVTSRGMFSADPARLRVRGRDDRLRWWAGPWPDDERWWDPDRASGRTARAQVLLDGDPGTALLLCYRQRRWYLEGSYE
Atome Classification :
(20 SA)
------.........10--....--.....20-----------....------...--.30.....-------.-----------------------------------.-------.40........50....--....60......---..70.----------------------------------.-......80.....-...90.--.......100......--.110.-----.--------------------------------------------------..-.----------------------------------------------------.-.120.......-130-.......140.......150...-----.-----...160......--..-170..-----....--.180.......190...-------.--....200...-....210....-.------------------..220.......230....-------...240....-----...250.--..-.....260.......270....-...----.--.------280.......290-.-------------.------....---..300-...----.--...310-...--......--320......---.330.--........340.......350.......360.......370....---...380......--.390.......400.......410.......420.......430.......440......-------.450.......460.......470.......480.......490.......500.......510.......520.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------MMAS
A
R
V
L
A
I
---
W
CMD--
W
P
A
V
A
A
A
-----------
A
AAG------LSA--TA
P
V
A
V
T
L-------A-----------------------------------N-------
R
V
I
A
CS
A
T
A
R
A
A
G
V
R
R
G
--
L
R
R
R
E
A
A
ARCP
Q
---
L
F
I
A
T----------------------------------A-DADR
D
A
R
L
F
E
G
V
I
-
A
A
V
D
D
L--V
P
R
A
E
LLRP
G
L
L
V
L
PV--R
G
P
A
R
-----F--------------------------------------------------FG-
S
----------------------------------------------------
E
-
Q
M
A
A
E
R
L
I
D
A
V
-
A
AA-GA
E
C
Q
V
G
I
A
D
R
L
S
T
A
V
F
A
ARAG
R
-----
I
-----VEPG-G
D
A
R
F
L
S
--
L
L
-
S
I
R
Q
L
-----ATEP--SLSGPG
R
D
D
L
T
D
-
L
L
W
R
-------
M
--
G
I
R
T
I
G
Q
F
A
A-L
S
R
T
D
V
A
S
RFG-
A
------------------
D
A
V
A
A
H
RFARGEPERAPCG-------REPP
P
D
L
A
A
E-----LACD-PP--I
D
-
R
V
D
A
A
A
FA
G
R
S
L
A
A
E
L
--
H
R
A
L
-
M
A
A----G--V------G
C
T
R
L
A
I
H
A
V
TA--N-------------
G
------
E
E
R
S
---
R
V
W
R
C-AEP----L--TEDA---TA
D
--
R
V
R
W
Q
L
--
D
G
W
LNNRNA---RD--R--P
T
A
A
V
T
L
L
R
L
Q
A
V
E
TVSASEGLQLPLWGGLG
E
Q
D
R
L
R
A
R
R
A
L
V
R
V
---
Q
GLLGP
E
A
V
R
V
P
--
V
LSGGHGPA
E
R
I
T
L
T
V
L
G
LVAPEPVPQADPGQPWPGRLPDPSP
A
V
LFDD
P
V
D
L
LDAQGN
P
-------
I
R
V
T
SRGMFSADP
A
R
L
R
V
RGRDD
R
L
R
WWAGPWPDDERWWDPDRASGRT
A
R
A
Q
V
L
L
DGDP
G
T
A
L
L
L
C
Y
R
Q
R
R
W
Y
LEGSYE
25
HHSearch
90.49
16%
-101
- C2 -
3GQC
-
REV1_HUMAN
A:
[416-828]
---------
Q
S
C
I
M
H
V
---
D
M
D
C
--
F
F
V
S
V
G
I
-----------
R
N
R
P
------
D
L
K
--
G
K
P
V
A
V
T
S
-------
N
RGTGRAPLRPGAN
P
Q
L
E
W
Q
Y
Y
Q
N
KILKGIDSVLSR
A
-------
E
I
A
S
C
S
Y
E
A
R
Q
L
G
I
K
N
G
--
M
F
F
G
H
A
K
Q
L
C
P
N
---
L
Q
A
V
P
----------------------------------
Y
-
D
F
H
A
Y
K
E
V
A
Q
T
L
Y
-
E
T
L
A
S
Y
--
T
H
N
I
E
A
V
S
C
D
E
A
L
V
D
I
--
T
E
I
L
A
-----
E
--------------------------------------------------
T
K
L
T
----------------------------------------------------
P
-
D
E
F
A
N
A
V
R
M
E
I
K
D
Q
T
-
K
C
A
A
S
V
G
I
G
S
N
I
L
L
A
R
M
A
T
R
K
A
K
-----
P
D
G
Q
Y
H
L
K
P
E
-
E
V
D
D
F
I
R
--
G
Q
-
L
V
T
N
L
-----
P
--------
G
V
G
H
-
S
M
E
S
-
K
L
A
S
-------
L
--
G
I
K
T
C
G
D
L
Q
Y
-
M
T
M
A
K
L
Q
K
E
F
G
-
P
K
-----------------
T
G
Q
M
L
Y
R
F
C
R
G
L
D
D
R
P
V
R
T
-------
E
K
E
R
K
S
V
S
A
E
-----
I
N
Y
G
-
I
R
--
F
T
-
Q
P
K
E
A
E
A
F
L
L
S
L
S
E
E
I
--
Q
R
R
L
-
E
A
T
----
G
--
M
------
K
G
K
R
L
T
L
K
I
M
V
R
--
K
PGAPVETAK----
F
GGH
G
I
C
D
N
I
A
---
R
T
V
T
L
-
D
Q
A
----
T
--
D
N
A
K
---
I
I
G
--
K
A
M
L
N
M
-----
F
H
T
M
------
K
--
L
--
N
I
S
D
M
R
G
V
G
I
H
V
N
Q
L
V
P
T
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
87.80
19%
-101
- C2 -
4ECQ
7
POLH_HUMAN
A:
[8-434]
--------
Q
D
R
V
V
A
L
V
---
D
M
D
C
--
F
F
V
Q
V
E
Q
-----------
R
Q
N
P
------
H
L
R
--
N
K
P
C
A
V
V
Q
-------
Y
KSWKG------------------------------
G
-------
G
I
I
A
V
S
Y
E
A
R
A
F
G
V
T
R
S
--
M
W
A
D
D
A
K
K
L
C
P
D
---
L
L
L
A
Q
V
R
ESRGK---------------------------
A
-
N
L
T
K
Y
R
E
A
S
V
E
V
M
-
E
I
M
S
R
F
--
A
-
V
I
E
R
A
S
I
D
E
A
Y
V
D
L
--
T
S
A
V
Q
E
R
L
Q
K
L
--------------------------------------------------
Q
G
-
Q
P
I
S
ADLLPSTYIEGLPQGPTVQ
K
E
G
M
R
K
Q
G
L
F
Q
W
L
D
S
LQIDNLTS
P
D
L
Q
L
T
V
G
-
A
V
I
V
E
E
M
R
A
A
I
E
R
E
T
-
G
F
Q
C
S
A
G
I
S
H
N
K
V
L
A
K
L
A
C
G
L
N
K
-----
P
N
R
Q
T
L
V
S
H
G
-
S
V
P
Q
L
F
S
--
Q
M
-
P
I
R
K
I
-----
R
--------
S
L
G
G
-
K
L
G
A
S
V
I
E
I
-------
L
--
G
I
E
Y
M
G
E
L
T
Q
-
F
T
E
S
Q
L
Q
S
H
F
G
-
E
K
-----------------
N
G
S
W
L
Y
A
M
C
R
G
I
E
H
D
P
V
K
P
-------
R
Q
L
P
K
T
I
G
C
S
-----
K
N
F
P
-
G
K
TA
L
A
-
T
R
E
Q
V
Q
W
W
L
L
Q
L
A
Q
E
L
--
E
E
R
L
-
T
K
D
R
N
D
N
D
--
R
------
V
A
T
Q
L
V
V
S
I
R
V
Q
--
G
-------------
D
------
K
R
L
S
S
L
R
R
C
C
A
L
-
T
R
Y
--------
D
A
H
---
K
M
S
--
H
---
D
A
--
F
T
V
I
K
N
C
N
T
SGI
Q
T
--
E
--
W
S
P
P
L
T
M
L
F
L
C
A
T
K
F
S
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
85.18
18%
-94
- C2 -
4Q45
5
DPO4_ECOLI
F:
[2-342]
---------
S
R
K
I
I
H
V
---
D
M
D
C
--
F
F
A
A
V
E
M
-----------
R
D
N
P
------
A
L
R
--
D
I
P
I
A
I
G
G
SRER---
R
-----------------------------------
G
-------
V
I
S
T
A
N
Y
P
A
R
K
F
G
V
R
S
A
--
M
P
T
G
M
A
L
A
L
C
P
H
---
L
T
L
L
P
----------------------------------
G
-
R
F
D
A
Y
K
E
A
S
N
H
I
R
-
E
I
F
S
R
Y
--
T
S
R
I
E
P
L
S
L
D
E
A
Y
L
D
V
--
T
D
S
V
H
-----
C
--------------------------------------------------
H
G
-
S
----------------------------------------------------
A
-
T
L
I
A
Q
E
I
R
Q
T
I
F
N
E
L
-
Q
L
T
A
S
A
G
V
A
P
V
K
F
L
A
K
I
A
S
D
M
N
K
-----
P
NGQFV
I
T
P
A
-
E
V
P
A
F
L
Q
--
T
L
-
P
L
A
K
I
-----
P
--------
G
V
G
K
-
V
S
A
A
-
K
L
E
A
-------
M
--
G
L
R
T
C
G
D
V
Q
A
-
C
D
L
V
M
L
L
K
R
F
G
-
K
------------------
F
G
R
I
L
W
E
R
S
Q
G
I
D
E
R
D
V
N
S
-------
E
R
L
R
K
S
V
G
V
E
-----
R
T
M
A
-
E
D
--
I
H
-
H
W
S
E
C
E
A
I
I
E
R
L
Y
P
E
L
--
E
R
R
L
-
A
K
V
----
K
PD
L
------
L
I
A
R
Q
G
V
K
L
K
F
D
--
D
-------------
F
------
Q
Q
T
T
-----
Q
E
H
-
V
W
P
----
R
--
L
N
K
A
---
D
L
I
--
A
T
A
R
K
-----
T
W
D
-------
E
R
--
R
--
G
G
R
G
V
R
L
V
G
L
H
V
T
L
L
D
P
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
83.16
16%
-102
* C2 *
3OSN
6
POLI_HUMAN
A:
[26-414]
--------
S
S
R
V
I
V
H
V
---
D
L
D
C
--
F
Y
A
Q
V
E
M
-----------
I
S
N
P
------
E
L
K
--
D
K
P
L
G
V
Q
Q
-------
K
-----------------------------------
Y
-------
L
V
V
T
C
N
Y
E
A
R
K
L
G
V
K
K
L
--
M
N
V
R
D
A
K
E
K
C
P
Q
---
L
V
L
V
N
----------------------------------
G
E
D
L
T
R
Y
R
E
M
S
Y
K
V
T
-
E
L
L
E
E
F
--
S
P
V
V
E
R
L
G
F
D
E
N
F
V
D
L
--
T
E
M
V
E
-----
K
R
L
Q
Q
LQSDELSA
V
T
V
S
G
HV-------------------------------
Y
N
-
N
Q
S
I
N
LLD
V
L
H
I
R
L
L
V
-------------------------------------
G
-
S
Q
I
A
A
E
M
R
E
A
M
Y
N
Q
L
-
G
L
T
G
C
A
G
V
A
S
N
K
L
L
A
K
L
V
S
G
V
F
K
-----
P
N
Q
Q
T
V
L
L
P
E
-
S
C
Q
H
L
I
H
--
S
L
N
H
I
K
E
I
-----
P
--------
G
I
G
Y
-
K
T
A
K
-
C
L
E
A
-------
L
--
G
I
N
S
V
R
D
L
Q
T
-
F
S
P
K
I
L
E
K
E
L
G
-
I
S
-----------------
V
A
Q
R
I
Q
K
L
S
F
G
E
D
N
S
P
V
I
L
-------
S
G
P
P
Q
S
F
S
E
E
-----
D
S
F
K
-
K
---
C
S
-
S
E
V
E
A
K
N
K
I
E
E
L
L
A
S
L
--
L
N
R
V
-
C
Q
D
----
G
--
R
------
K
P
H
T
V
R
L
I
I
R
R
Y
--
S
-------------
S
E
K
H
Y
--
G
R
E
S
---
R
Q
C
P
I
-
P
S
H
VIQK-----
Y
D
V
M
T
P
M
V
--
D
I
L
M
K
-----
L
F
R
N
M
V
----
N
V
--
K
--
M
P
F
H
L
T
L
L
S
V
C
F
C
N
L
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
82.02
16%
-86
- C2 -
3MFI
7
POLH_YEAST
A:
[28-517]
-------
S
S
L
A
C
I
A
H
I
---
D
M
N
A
--
F
F
A
Q
V
E
Q
-----------
M
R
C
G
------
L
S
K
--
E
D
P
V
V
C
V
Q
-------
W
-----------------------------------
N
-------
S
I
I
A
V
S
Y
A
A
R
K
Y
G
I
S
R
M
--
D
T
I
Q
E
A
L
K
K
C
S
N
---
L
I
P
I
H
T
A
VFKKGED
F
W
Q
Y
HDGCGSWVQDPAKQISVED
H
K
V
-
S
L
E
P
Y
R
R
E
S
R
K
A
L
-
A
I
F
K
W
A
--
C
D
L
V
E
R
A
S
I
D
E
V
F
L
D
L
--
G
R
I
C
F
-----
N
M
L
M
FDNEYELTGDLK
L
K
D
A
L
S
N
I
R
E
A
F
I
G
GNYDINSHLPLIPEKIKS
L
K
F
E
G
-
D
VFNPEGRDLITD
W
D
D
V
I
L
A
L
--------------------------------
G
-
S
Q
V
C
K
G
I
R
D
S
I
K
D
I
L
-
G
Y
T
T
S
C
G
L
S
S
T
K
N
V
C
K
L
A
S
N
Y
K
K
-----
P
D
A
Q
T
I
V
K
N
D
-
C
L
L
D
F
L
D
CG
K
F
-
E
I
T
S
F
-----
W
--------
T
L
G
G
-
V
L
G
K
-
E
L
I
D
V
L
DLPHE
N
--
S
I
K
H
I
R
E
T
W
P
-
D
N
A
G
Q
L
K
E
F
L
D
-
A
K
V
K
QSDYDSNIDPLK
T
A
D
L
A
E
K
L
F
K
L
S
R
G
R
Y
G
L
P
L
S
S
-------
R
P
V
V
K
S
M
M
S
N
-----
K
N
L
R
G
K
S
--
C
N
-
S
I
V
D
C
I
S
W
L
E
V
F
C
A
E
L
--
T
S
R
I
-
Q
D
L
----
E
--
Q
E
Y
N
K
I
V
I
P
R
T
V
S
I
S
L
K
T
K
--
S
-------------
Y
------
E
V
Y
R
---
K
S
G
P
V
-
A
Y
K
----
G
IN
F
Q
S
H
---
E
L
L
--
K
V
G
I
K
-----
F
V
T
D
L
D
I
---
K
G
KN
K
--
S
Y
Y
P
L
T
K
L
S
M
T
I
T
N
F
D
I
I
D
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
77.44
14%
-99
- C2 -
4F50
3
DPO4_SULAC (first)
A:
[1-342]
----------
M
I
V
I
F
V
---
D
F
D
Y
--
F
F
A
Q
V
E
E
-----------
V
L
N
P
------
Q
Y
K
--
G
K
P
L
V
V
C
V
-------
Y
SS---------------------------------
G
-------
A
V
A
T
A
N
Y
E
A
R
K
L
G
V
K
A
G
--
M
P
I
I
K
A
M
Q
I
A
P
S
---
A
I
Y
V
P
----------------------------------
M
-
R
K
P
I
Y
E
A
F
S
N
R
I
M
-
N
L
L
N
K
H
--
A
D
K
I
E
V
A
S
I
D
E
A
Y
L
D
V
--
T
N
K
V
E
G----
N
--------------------------------------------------
F
E
-
N
----------------------------------------------------
G
-
I
E
L
A
R
K
I
K
Q
E
I
L
E
K
E
-
K
I
T
V
T
V
G
V
A
P
N
K
I
L
A
K
I
I
A
D
K
S
K
-----
P
N
G
L
G
V
I
R
P
T
-
E
V
Q
D
F
L
N
--
E
L
-
D
I
D
E
I
-----
P
--------
G
I
G
S
-
V
L
A
R
-
R
L
N
E
-------
L
--
G
I
Q
K
L
R
D
I
L
S
-
K
N
Y
N
E
L
E
K
I
T
G
-
K
A
-----------------
K
A
L
Y
L
L
K
L
A
Q
N
K
Y
S
E
P
V
E
N
-------
K
S
-
K
I
P
H
G
R
I
-----
V
T
M
K
-
R
N
--
S
R
-
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
--
Y
Y
K
L
-
D
K
R
--------------
I
P
K
A
I
H
V
V
A
V
T
E
--
D
-------------
L
------
D
I
V
S
---
R
G
R
T
F
-
P
H
G
----
I
--
S
K
E
T
---
A
Y
S
--
E
S
V
K
L
L
--
Q
K
I
L
E
-----------
E
--
D
E
R
K
I
R
R
I
G
V
R
F
S
K
F
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
74.85
21%
-92
- C2 -
4DEZ
-
?
A:
[2-239]
---------
T
K
W
V
L
H
V
---
D
L
D
Q
--
F
L
A
S
V
E
L
-----------
R
R
R
P
------
D
L
R
--
G
Q
P
V
I
V
G
G
-------
S
R----------------------------------
K
-------
V
V
T
C
A
S
Y
E
A
R
E
F
G
V
H
A
G
--
M
P
L
R
A
A
A
R
R
C
P
D
---
A
T
F
L
P
----------------------------------
S
-
D
P
A
A
Y
D
E
A
S
E
Q
V
M
-
G
L
L
R
D
L
--
G
H
P
L
E
V
W
G
W
D
E
A
Y
L
G
A
--
D
L
P
D
---------------------------------------------------------
E
S
-
D
----------------------------------------------------
P
-
V
E
V
A
E
R
I
R
T
V
V
A
A
E
T
-
G
L
S
C
S
V
G
I
S
D
N
K
Q
R
A
K
V
A
T
G
F
A
K
-----
P
A
G
I
Y
V
L
T
E
A
-
N
W
M
T
V
M
G
--
D
R
-
P
P
D
A
L
-----
W
--------
G
V
G
P
-
K
T
T
K
-
K
L
A
A
-------
M
--
G
I
T
T
V
A
D
L
A
V
-
T
D
P
S
V
L
T
T
A
F
G
-
P
S
-----------------
T
G
L
W
L
L
L
L
A
K
G
G
G
D
T
E
V
S
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
74.59
14%
-104
- C2 -
2AQ4
5
REV1_YEAST
A:
[50-433]
--------
D
T
Y
I
I
F
H
I
---
D
F
D
C
--
F
F
A
T
V
A
Y
-----------
L
C
R
S
SSFSAC
D
F
K
--
R
D
P
I
V
V
C
H
-------
G
TKN--------------------------------
S
-------
D
I
A
S
C
N
Y
V
A
R
S
Y
G
I
K
N
G
--
M
W
V
S
Q
A
E
K
M
L
P
N
G
I
K
L
I
S
L
P
----------------------------------
Y
-
T
F
E
Q
F
Q
L
K
S
E
A
F
Y
-
S
T
L
K
R
L
NI
F
N
L
I
L
P
I
S
I
D
E
A
V
C
V
R
I
I
P
D
--------------------------------------------------------------
T
----------------------------------------------------
L
N
A
R
L
C
E
E
I
R
Q
E
I
F
Q
G
T
N
G
C
T
V
S
I
G
C
S
D
S
L
V
L
A
R
L
A
L
K
M
A
K
-----
P
N
G
Y
N
I
T
F
K
S
N
L
S
E
E
F
W
S
--
S
F
-
K
L
D
D
L
-----
P
--------
G
V
G
H
-
S
T
L
S
-
R
L
E
S
-------
T
F
D
S
P
H
S
L
N
D
L
R
K
R
Y
T
L
D
A
L
K
A
S
V
G
-
S
K
-----------------
L
G
M
K
I
H
L
A
L
Q
G
Q
D
D
E
E
S
L
K
ILYD
P
K
E
V
L
Q
R
K
S
L
S
I
D
-----
I
N
W
G
-
I
R
--
F
K
-
N
I
T
Q
V
D
L
F
I
E
R
G
C
Q
Y
L
--
L
E
K
L
-
N
E
I
----
N
--
K
------
T
T
S
Q
I
T
L
K
L
M
R
R
CK
D
APIEPPKYMGM
G
R
C
------
D
S
F
S
---
R
S
S
R
L
-
G
I
P
----
T
--
N
E
F
G
---
I
I
A
--
T
E
M
K
S
L
-----
Y
R
T
L
------
G
--
C
--
P
P
M
E
L
R
G
L
A
L
Q
F
N
K
L
V
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
Fugue
71.05
15%
-95
- C2 -
1K1Q
-
DPO4_SULSF
A:
[1-344]
-------------
M
I
V
---
I
F
V
D
--
F
D
Y
F
F
A
Q
-----------
V
E
E
V
------
L
N
P
--
Q
Y
K
-
G
K
P
L
-------
V
-----------------------------------
V
-------
S
V
Y
S
A
N
Y
E
A
R
K
L
G
V
K
A
G
--
M
P
I
I
K
A
M
Q
I
A
P
S
---
A
I
Y
V
P
----------------------------------
M
-
R
K
P
I
Y
E
A
F
S
N
R
I
M
-
N
L
L
N
K
H
--
A
D
K
I
E
V
A
S
I
D
E
A
Y
L
D
V
--
T
N
K
V
E
G----
N
--------------------------------------------------
F
E
-
N
----------------------------------------------------
G
-
I
E
L
A
R
K
I
K
Q
E
I
-
L
E
K
E
K
I
T
V
T
V
G
V
A
P
N
K
I
L
A
K
I
I
A
D
K
S
K
PN
G
L
G
V
-----
I
R
P
T
-
E
V
Q
D
F
L
N
--
E
L
-
D
I
D
E
I
-------------
P
G
I
G
S
V
L
A
R
R
-
L
N
-
E
-------
L
--
G
I
Q
K
L
R
D
I
L
S
-
K
N
Y
N
E
L
E
K
I
T
G
K
A
------------------
K
A
L
Y
L
L
K
L
A
Q
N
K
Y
S
E
-
P
V
E
-------
N
K
S
K
I
P
H
G
R
Y
-----
L
T
L
P
-
Y
N
--
T
R
-
D
V
K
V
I
L
---
P
Y
L
K
K
A
I
--
N
E
A
Y
-
N
K
V
----
N
--
G
------
I
P
M
R
I
T
V
I
A
I
M
E
--
D
-------------
L
------
D
I
L
S
---
K
G
K
K
F
-
K
H
G
----
I
--
S
I
D
N
---
A
Y
K
--
V
A
E
D
L
L
--
R
E
L
L
V
R
D
K
R
---
R
N
--
V
--
R
R
I
G
V
K
L
D
N
I
I
I
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
70.53
14%
-104
- C2 -
4TQR
7
DPO4_SULSO
A:
[1-341]
----------
M
I
V
L
F
V
---
D
F
D
Y
--
F
Y
A
Q
V
E
E
-----------
V
L
N
P
------
S
L
K
--
G
K
P
V
V
V
C
V
FSGRFED
S
-----------------------------------
G
-------
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
--
I
P
I
V
E
A
K
K
I
L
P
N
---
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
M
-
N
L
L
R
E
Y
--
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
--
S
D
K
V
R
-----
D
--------------------------------------------------
Y
R
-
E
----------------------------------------------------
A
-
Y
N
L
G
L
E
I
K
N
K
I
L
E
K
E
-
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
-----
P
N
G
I
K
V
I
D
D
E
-
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
-----
P
--------
G
I
G
N
-
I
T
A
E
-
K
L
K
K
-------
L
--
G
I
N
K
L
V
D
T
L
S
-
I
E
F
D
K
L
K
G
M
I
G
-
E
A
-----------------
K
A
K
Y
L
I
S
L
A
R
D
E
Y
N
E
P
I
R
T
--------
R
V
R
K
S
I
G
R
I
-----
V
T
M
K
-
R
N
--
S
R
-
N
L
E
E
I
K
P
Y
L
F
R
A
I
E
E
S
--
Y
Y
K
L
-
D
K
R
----
I
----------
P
K
A
I
H
V
V
A
V
T
E
--
D
-------------
L
------
D
I
V
S
---
R
G
R
T
F
-
P
H
G
----
I
--
S
K
E
T
----
A
Y
--
S
E
S
V
K
-----
L
L
Q
-------
K
I
L
-
E
E
-
D
E
R
K
I
R
R
I
G
V
R
F
S
K
F
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
63.40
14%
-58
- C2 -
1T3N
2
POLI_HUMAN
A:
[1-388]
---------
S
R
V
I
V
H
V
---
D
L
D
C
--
F
Y
A
Q
V
E
M
-----------
I
S
N
P
------
E
L
K
--
D
K
P
L
G
V
Q
Q
-------
K
-----------------------------------
Y
-------
L
V
V
T
C
N
Y
E
A
R
K
L
G
V
K
K
L
--
M
N
V
R
D
A
K
E
K
C
P
Q
L--
V
L
V
N
G
----------------------------------
E
-
D
L
T
R
Y
R
E
M
S
Y
K
V
T
-
E
L
L
E
E
F
--
S
P
V
V
E
R
L
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
-
F
D
E
N
F
V
D
--
L
T
-
E
M
V
E
K
-----
R
L
Q
Q
--
L
Q
S
D
E
------------------------------------------
L
S
-
A
------------------
V
T
V
S
G
H
V
Y
N
N
Q
S
I
N
L
L
----------------------------
D
-
V
L
--
H
I
-
R
L
L
V
G
S
Q
I
A
A
E
M
R
E
A
M
--
Y
N
Q
L
G
L
T
G
----
C
--
A
------
G
V
A
S
N
K
L
L
A
K
L
V
--
S
-------------
G
------
V
F
K
P
---
N
Q
Q
T
V
-
L
------------------------------------
L
P
---
E
S
--
C
--
Q
H
L
I
H
S
L
N
H
I
K
E
I
P
G
I
G
Y
K
T
A
K
C
L
E
A
-
L
G
I
N
S
V
R
D
L
Q
T
F
S
P
K
I
L
E
---
K
E
L
G
I
S
V
A
Q
R
I
Q
--
K
L
S
F
G
E
D
N
S
P
--------
V
I
L
S
G
P
P
Q
S
F
S
E
E
D
S
F
K
K
C
S
S
E
V
E
A
K
N
K
I
E
E
L
L
A
S
L
L
N
R
V
C
Q
D
GRKPH
T
V
R
L
I
I
R
R
Y
S
S
E
K
H
Y
G
R
E
S
R
Q
C
P
I
P
S
H
V
I
Q
K
L
G
T
G
N
Y
D
V
M
T
P
M
V
D
I
L
M
K
L
F
R
N
M
V
N
V
K
M
P
F
H
L
T
L
L
S
V
C
F
C
N
L
K
------
44
Fugue
61.31
17%
-99
- C2 -
1JX4
5
DPO4_SULSO
A:
[2-204]
-----------
I
V
L
F
V
---
D
F
D
Y
--
F
Y
A
Q
V
E
E
-----------
V
L
N
P
------
S
L
K
--
G
K
P
V
V
V
C
V
-------
F
-----------------------------------
S
GRFEDSG
A
V
A
T
A
N
Y
E
A
R
K
F
G
V
K
A
G
--
I
P
I
V
E
A
K
K
I
L
P
N
---
A
V
Y
L
P
----------------------------------
M
-
R
K
E
V
Y
Q
Q
V
S
S
R
I
-
M
N
L
L
R
E
Y
--
S
E
K
I
E
I
A
S
I
D
E
A
Y
L
D
I
--
S
D
K
V
R
-----
D
--------------------------------------------------
Y
R
-
E
----------------------------------------------------
A
-
Y
N
L
G
L
E
I
K
N
K
I
-
L
E
K
E
K
I
T
V
T
V
G
I
S
K
N
K
V
F
A
K
I
A
A
D
M
A
K
PN
G
I
K
V
-----
I
D
D
E
-
E
V
K
R
L
I
R
--
E
L
-
D
I
A
D
V
PGIG
N
I
T
A
E
--
K
L
K
K
L
G
I
N
K
L
V
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
Fugue
60.72
16%
-105
- C2 -
1IM4
3
DPO4_SULSF
A:
[2-210]
------
H
H
H
H
H
I
V
I
F
V
---
D
F
D
Y
--
F
F
A
Q
V
E
E
-----------
V
L
N
P
------
Q
Y
K
--
G
K
P
L
V
V
C
V
-------
Y
-----------------------------------
S
T
S
G
----
A
V
A
T
A
N
Y
E
A
R
K
L
G
V
K
A
G
--
M
P
I
I
K
A
M
Q
I
A
P
S
---
A
I
Y
V
P
----------------------------------
M
-
R
K
P
I
Y
E
A
F
S
N
R
I
M
-
N
L
L
N
K
H
--
A
D
K
I
E
V
A
S
I
D
E
A
Y
L
D
V
--
T
N
K
V
E
G----
N
--------------------------------------------------
F
E
-
N
----------------------------------------------------
G
-
I
E
L
A
R
K
I
K
Q
E
I
-
L
E
K
E
K
I
T
V
T
V
G
V
A
P
N
K
I
L
A
K
I
I
A
D
K
S
K
PN
G
L
G
V
-----
I
R
P
T
-
E
V
Q
D
F
L
N
--
E
L
-
D
I
D
E
I
PGIG
S
V
L
A
R
--
R
L
N
E
L
G
I
Q
K
L
R
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
Fugue
57.10
18%
-48
* C1 *
3ACP
-
RPN14_YEAST
A:
[1-417]
------
M
T
K
T
I
T
V
A
H
I
---
Q
-
Y
D
--
F
K
A
V
L
E
E
NDE
N
D
D
E
F
Y
I
N
V
D
K
N
------
L
N
E
--
I
K
E
H
K
I
V
V
-------
L
-----------------------------------
G
-------
N
S
R
G
V
D
A
G
K
G
N
T
F
E
K
V
G
--
S
H
L
Y
K
A
R
L
D
G
H
D
---
F
L
F
N
T
----------------------------------
I
-
I
R
D
G
S
K
M
L
K
R
A
D
Y
-
T
A
V
D
T
A
--
K
L
Q
M
R
R
F
I
L
G
T
----
T
--
E
G
D
I
K
-----
V
--------------------------------------------------
L
D
-
S
----------------------------------------------------
N
--
F
N
L
Q
R
E
I
D
Q
A
-
H
V
-----------
S
E
I
T
K
L
K
F
F
P
S
G
E
A
-----
L
-----
I
S
S
S
-
Q
D
M
Q
-
L
K
--
I
W
-
S
V
K
D
G
-----
S
N
P
R
--
T
L
I
G
-----------
H
R
-------
A
--
T
V
T
D
I
A
I
I
D
R
-
G
R
N
V
L
S
A
S
L
D
G
-
T
--------------------
I
R
L
W
E
C
G
T
G
T
T
I
H
T
F
N
R
-------
K
E
N
P
H
D
G
V
N
S
-----
I
A
L
F
-
V
G
--
T
D
-
R
Q
L
H
E
I
S
T
S
K
K
N
N
L
E
F
GT
Y
G
K
Y
-
V
I
A
----
G
--
H
------
V
S
G
V
I
T
V
H
N
V
F
S
--
K
-------------
E
------
Q
T
I
Q
L
P
-
S
K
F
T
C
S
C
N
S
----
L
--
T
V
D
G
---
N
N
A
--
N
Y
I
Y
A
G
Y
E
N
G
M
L
A
Q
W
D
L
---
R
S
--
P
EC
P
V
G
E
F
L
I
N
E
G
T
P
I
N
N
V
Y
F
A
A
G
-------------------------------------
A
L
--
F
V
S
S
G
F
D
T
S
I
K
L
D
I
I
S
------------
D
P
--------
E
S
E
R
P
A
I
E
F
E
T
P
T
F
L
V
S
---
N
D
-------
D
E
V
S
Q
F
C
Y
V
S
D
D
E
S
N
-----------------------------------
G
E
V
L
E
V
G
K
N
N
F
C
A
L
Y
N
L
S
N
P
---------
10
PsiBlast_PDB
51.91
27%
-73
- C2 -
3EPI
3
POLI_HUMAN
A:
[25-140]
--------
A
S
S
R
V
I
V
H
---
V
D
L
D
C
F
Y
A
Q
V
E
M
I
-----------
S
N
P
E
------
L
K
---
D
K
P
L
G
V
Q
Q
-------
K
-----------------------------------
Y
-------
L
V
V
T
C
N
Y
E
A
R
K
L
G
V
K
K
L
--
M
N
V
R
D
A
K
E
K
C
P
Q
---
L
V
L
V
N
----------------------------------
G
E
D
L
T
R
Y
R
E
M
S
Y
K
V
T
-
E
L
L
E
E
F
--
S
P
V
V
E
R
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
51.02
27%
-72
- C2 -
3OSN
5
POLI_HUMAN
A:
[25-128]
--------
A
S
S
R
V
I
V
H
---
V
D
L
D
C
F
Y
A
Q
V
E
M
I
-----------
S
N
P
E
------
L
K
---
D
K
P
L
G
V
Q
Q
-------
K
-----------------------------------
Y
-------
L
V
V
T
C
N
Y
E
A
R
K
L
G
V
K
K
L
--
M
N
V
R
D
A
K
E
K
C
P
Q
---
L
V
L
V
N
----------------------------------
G
E
D
L
T
R
Y
R
E
M
S
Y
K
V
T
-
E
L
L
E
E
F
--
S
P
V
V
E
R
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
52
Fugue
50.96
13%
-35
- C1 -
4JO0
8
?
A:
[1-534]
S
H
M
R
Y
S
L
R
Q
D
I
A
V
E
P
V
I
AG
W
Y
G
W
--
S
Y
L
L
P
P
Q
-----------
T
L
A
R
------
F
V
H
NR
F
N
R
I
V
E
S
Y
-------
L
-----------------------------------
D
-------
D
P
Q
V
H
A
A
A
V
R
Q
R
R
M
H
G
G
PW
I
H
A
H
E
H
R
D
A
I
E
A
---
W
Y
R
E
T
----------------------------------
A
-
P
R
R
E
R
L
D
E
L
F
E
A
V
-
R
R
L
E
E
D
--
I
-
L
P
R
H
H
G
E
C
L
D
P
V
Y
Q
--
E
L
P
A
A
-----
L
--------------------------------------------------
A
G
-
R
----------------------------------------------------
V
-
E
V
F
Y
G
R
------
D
N
R
-
T
A
D
Y
R
F
V
E
P
L
M
Y
A
S
E
Y
Y
D
E
S
W
Q
Q
-----
V
R
F
---
R
P
V
T
-
E
D
A
R
E
F
A
--
L
T
-
T
P
M
L
E
-----
Y
G
P
E
Q
L
L
V
N
V
P
L
N
S
P
L
L
D
-
A
V
F
R
-------
G
--
G
L
T
G
T
E
L
D
D
L
-
A
A
R
F
G
L
D
G
E
R
A
-
A
------------------
R
F
A
S
Y
F
E
P
T
P
E
E
D
V
L
E
Y
V
G
-------
H
---
A
C
V
F
A
R
H
RG
T
T
F
L
V
D
-
P
V
--
L
S
Y
S
G
Y
P
G
G
A
E
N
R
F
T
F
A
D
L
--
P
E
R
I
-
D
H
L
----
L
--
I
------
T
H
N
H
Q
D
H
M
L
F
E
T
--
L
-------------
L
------
R
I
R
H
---
R
V
G
R
V
-
L
V
P
----
K
--
S
T
N
A
---
S
L
V
DP
G
L
G
G
I
L
--
R
R
L
G
F
T
D
----------------
V
V
E
V
D
D
L
E
T
L
S
C
G
S
A
E
V
V
A
L
P
F
L
G
E
H
G
D
L
R
I
R
S
K
T
G
W
L
I
R
F
GE
R
S
V
L
F
A
A
D
S
T
N
I
S
PT
M
Y
T
K
V
A
E
V
I
G
P
V
D
T
V
F
I
G
M
E
S
I
------
G
A
A
A
S
W
I
Y
G
P
L
Y
G
E
P
L
D
R
R
T
D
Q
S
R
R
L
N
G
S
N
F
P
-------
Q
A
R
E
I
V
D
A
L
E
P
D
E
V
Y
V
Y
A
M
G
L
E
P
W
M
G
V
V
M
A
V
D
------
Y
D
E
S
H
P
A
I
V
D
S
D
L
L
V
R
H
V
Q
D
K
G
G
T
A
E
R
L
H
L
R
R
T
L
R
L
-----
13
PsiBlast_PDB
50.84
27%
-74
- C2 -
3G6Y
5
POLI_HUMAN
A:
[25-140]
--------
A
S
S
R
V
I
V
H
---
V
D
L
D
C
F
Y
A
Q
V
E
M
I
-----------
S
N
P
E
------
L
K
---
D
K
P
L
G
V
Q
Q
-------
K
-----------------------------------
Y
-------
L
V
V
T
C
N
Y
E
A
R
K
L
G
V
K
K
L
--
M
N
V
R
D
A
K
E
K
C
P
Q
---
L
V
L
V
N
----------------------------------
G
E
D
L
T
R
Y
R
E
M
S
Y
K
V
T
-
E
L
L
E
E
F
--
S
P
V
V
E
R
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
50.77
27%
-79
- C2 -
2ALZ
5
POLI_HUMAN
A:
[1-116]
--------
A
S
S
R
V
I
V
H
---
V
D
L
D
C
F
Y
A
Q
V
E
M
I
-----------
S
N
P
E
------
L
K
---
D
K
P
L
G
V
Q
Q
-------
K
-----------------------------------
Y
-------
L
V
V
T
C
N
Y
E
A
R
K
L
G
V
K
K
L
--
M
N
V
R
D
A
K
E
K
C
P
Q
---
L
V
L
V
N
----------------------------------
G
E
D
L
T
R
Y
R
E
M
S
Y
K
V
T
-
E
L
L
E
E
F
--
S
P
V
V
E
R
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
50.67
27%
-77
- C2 -
2DPJ
5
POLI_HUMAN
A:
[25-140]
--------
A
S
S
R
V
I
V
H
---
V
D
L
D
C
F
Y
A
Q
V
E
M
I
-----------
S
N
P
E
------
L
K
---
D
K
P
L
G
V
Q
Q
-------
K
-----------------------------------
Y
-------
L
V
V
T
C
N
Y
E
A
R
K
L
G
V
K
K
L
--
M
N
V
R
D
A
K
E
K
C
P
Q
---
L
V
L
V
N
----------------------------------
G
E
D
L
T
R
Y
R
E
M
S
Y
K
V
T
-
E
L
L
E
E
F
--
S
P
V
V
E
R
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------