@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3411c: (2016-05-19 )
MSRGMSGLEDSSDLVVSPYVRMGGLTTDPVPTGGDDPHKVAMLGLTFDDVLLLPAASDVVPATADTSSQLTKKIRLKVPLVSSAMDTVTESRMAIAMARAGGMGVLHRNLPVAEQAGQVEMVKRSEAGMVTDPVTCRPDNTLAQVDALCARFRISGLPVVDDDGALVGIITNRDMRFEVDQSKQVAEVMTKAPLITAQEGVSASAALGLLRRNKIEKLPVVDGRGRLTGLITVKDFVKTEQHPLATKDSDGRLLVGAAVGVGGDAWVRAMMLVDAGVDVLVVDTAHAHNRLVLDMVGKLKSEVGDRVEVVGGNVATRSAAAALVDAGADAVKVGVGPGSICTTRVVAGVGAPQITAILEAVAACRPAGVPVIADGGLQYSGDIAKALAAGASTAMLGSLLAGTAEAPGELIFVNGKQYKSYRGMGSLGAMRGRGGATSYSKDRYFADDALSEDKLVPEGIEGRVPFRGPLSSVIHQLTGGLRAAMGYTGSPTIEVLQQAQFVRITPAGLKESHPHDVAMTVEAPNYYAR
Atome Classification :
(59 SA)
.........10........20........30........40........50........60--........70------.........80........90........100.......110.......120.--......130.......140.......150.......160-.---.---......170.....-..180.....-..190-.--....-...200..---------.....210.-......220.......230.......240.......250-.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360....------...370.......380.......390.......400.......410.......420.......430-.....---..440.....-..450...-....460.......470.......480.......490.-....-.-.500.......510.......520.......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSRGMSGLEDSS
D
L
V
V
S
P
Y
VRMGGLTTDPVPTGGDDP
H
K
V
A
M
L
GLTFD
D
V
L
LLPAASDVVP--ATAD
T
S
S
Q
L
-------
T
K
K
I
R
L
KVP
L
V
S
S
A
M
D
T
V
T
E
S
R
M
A
I
A
M
ARAGGM
G
V
LHRNLPV
A
E
QAG
Q
V
E
M
V
K--RSEAGMVTDPVTCRPD
N
T
L
A
Q
V
D
A
L
C
A
R
F
RISGLPVVD--D---D---G
A
L
V
G
I
ITNR
D
M
R
F
-EVDQ
S
K
Q
V
A
E
-
V
M
T-K-A--P
L
I
T
-AQEGV
S
A
S
---------
A
A
L
G
L
L
R
RN-KIEKLPVVDGRG
R
L
T
G
L
I
T
V
K
D
F
V
KTEQHPLATKDSDG
R
-
L
L
V
G
A
AVGVG
G
D
A
W
V
R
A
M
M
L
VDAGV
D
V
L
V
V
DTAHAHN
R
L
V
L
D
M
V
G
K
L
K
S
E
VGD
R
V
E
V
VGGNVA
T
R
S
A
A
A
A
L
V
DAGA
D
A
V
K
VGVGPG
S
I
C
T
T
R
V
VAGVG
A
P
Q
I
T
A
I
L
E
A
V
A
ACRP------AG
V
P
V
IADGGLQYS
G
D
I
A
K
A
L
AAG
A
S
T
A
M
L
G
S
L
L
AGTAEAPG
E
L
I
F
VNG
K
Q
Y
K
S
YRGMGSLGAMRG-RGGAT---SYSKDRYFAD-DALSEDKL-VPEGIEGRVPFRG
P
L
S
S
V
I
H
Q
L
T
G
G
L
R
A
AMGYTGS
P
T
I
-
E
V
L
Q
-Q-A
Q
F
V
R
ITPAGLKESHPH
D
V
A
M
T
V
EAPNYYAR
121
HHSearch
84.39
55%
-93
- C2 -
4FXS
3
?
A:
[6-486]
---------------------------------------
I
A
K
E
A
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
P
--
N
T
A
D
L
R
T
R
L
-------
T
K
N
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
N
M
S
I
E
Q
Q
A
A
Q
V
H
Q
V
K
--
I
F
E
A
--
V
T
H
P
V
T
V
R
P
E
Q
T
I
A
D
V
M
E
L
T
H
Y
H
G
F
A
G
F
P
V
V
T
--
E
---
N
---
N
E
L
V
G
I
I
T
G
R
D
V
R
F
-
V
T
D
L
T
K
S
V
A
A
-
V
M
T
---
P
KE
R
L
A
T
-
V
K
E
G
-------------
E
V
Q
E
K
M
H
----
V
E
K
I
L
V
V
N
D
E
F
Q
L
K
G
M
I
T
A
K
-----
E
S
K
P
N
A
C
K
D
E
Q
G
R
-
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
S
K
-
G
---------
S
S
D
R
Y
F
Q
T
-----
A
D
K
L
-
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
-
E
D
L
R
T
K
-
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
---
6
PsiBlast_PDB
84.32
54%
-87
- C2 -
3TSB
2
?
A:
[29-509]
--------------------------------------
K
F
V
K
E
G
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
--
R
E
V
S
V
K
T
V
L
-------
S
E
S
L
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
M
S
I
E
Q
Q
A
E
Q
V
D
K
V
K
--
R
S
E
S
G
V
I
S
D
P
F
F
L
T
P
E
H
Q
V
Y
D
A
E
H
L
M
G
K
Y
R
I
S
G
V
P
V
V
N
NL
D
---
E
---
R
K
L
V
G
I
I
T
N
R
D
M
R
F
-
I
Q
D
Y
S
I
K
I
S
D
-
V
M
T
-
K
-
E
--
Q
L
I
T
-
A
P
V
G
T
T
L
S
---------
E
A
E
K
I
L
Q
K
Y
-
K
I
E
K
L
P
L
V
D
N
N
G
V
L
Q
G
L
I
T
I
K
D
I
E
K
V
I
E
F
P
N
S
A
K
D
K
Q
G
R
-
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
-
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
--
K
G
--------
S
K
D
R
Y
F
Q
E
----
G
N
K
K
L
-
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
-
E
F
L
R
-
E
N
A
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
P
H
H
V
Q
I
T
K
E
A
P
N
Y
---
10
PsiBlast_PDB
83.55
52%
-93
- C2 -
4FXS
3
?
A:
[5-486]
--------------------------------------
R
I
A
K
E
A
L
T
F
D
D
V
L
L
V
P
A
H
S
T
V
L
P
--
N
T
A
D
L
R
T
R
L
-------
T
K
N
I
A
L
N
I
P
M
V
S
A
S
M
D
T
V
T
E
A
R
L
A
I
A
L
A
Q
E
G
G
I
G
F
I
H
K
N
M
S
I
E
Q
Q
A
A
Q
V
H
Q
V
K
--
I
F
E
A
--
V
T
H
P
V
T
V
R
P
E
Q
T
I
A
D
V
M
E
L
T
H
Y
H
G
F
A
G
F
P
V
V
T
--
E
---
N
---
N
E
L
V
G
I
I
T
G
R
D
V
R
F
-
V
T
D
L
T
K
S
V
A
A
-
V
M
T
P
K
-
E
--
R
L
A
T
-
V
K
E
G
-------------
E
V
Q
E
K
M
H
----
V
E
K
I
L
V
V
N
D
E
F
Q
L
K
G
M
I
T
A
K
-----
E
S
K
P
N
A
C
K
D
E
Q
G
R
-
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
-
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
-------
S
---
K
G
S
S
D
R
Y
F
Q
T
----
A
-
D
K
L
-
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
-
E
D
L
R
T
K
-
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
---
125
HHSearch
83.23
97%
-108
- C2 -
4ZQM
2
IMDH_MYCTU
A:
[31-387]
---------------------------
D
P
V
P
T
G
G
D
D
P
H
K
V
A
M
L
G
L
T
F
D
D
V
L
L
L
P
A
A
S
D
V
V
P
--
A
T
A
D
T
S
S
Q
L
-------
T
K
K
I
R
L
K
V
P
L
V
S
S
A
M
D
T
V
T
E
S
R
M
A
I
A
M
A
R
A
G
G
M
G
V
L
H
R
N
L
P
V
A
--------------------------------
E
Q
A
G
Q
V
E
M
----------------------------------------------------------------------------------
V
K
R
S
---
G
G
L
L
------------------------------------
V
G
A
A
V
G
V
G
G
D
A
W
V
R
A
M
M
L
V
D
A
G
V
D
V
L
V
V
D
T
A
H
A
H
N
R
L
V
L
D
M
V
G
K
L
K
S
E
V
G
D
R
V
E
V
V
G
G
N
V
A
T
R
S
A
A
A
A
L
V
D
A
G
A
D
A
V
K
V
G
V
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
A
P
Q
I
T
A
I
L
E
A
V
A
A
C
R
P
------
A
G
V
P
V
I
A
D
G
G
L
Q
Y
S
G
D
I
A
K
A
L
A
A
G
A
S
T
A
M
L
G
S
L
L
A
G
T
A
E
A
P
G
E
L
I
F
V
N
G
K
Q
Y
K
S
Y
R
G
M
G
S
L
G
A
M
-----------------------------
L
-
V
P
E
G
I
E
G
R
V
P
F
R
G
P
L
S
S
V
I
H
Q
L
T
G
G
L
R
A
A
M
G
Y
T
G
S
P
T
I
-
E
V
L
Q
-
Q
-
A
Q
F
V
R
I
T
P
A
G
L
--------------------
117
HHSearch
81.85
52%
-87
- C2 -
1ZFJ
1
IMDH_STRPY
A:
[8-490]
----------------------------------------
L
K
K
G
Y
T
F
D
D
V
L
L
I
P
A
E
S
H
V
L
P
--
N
E
V
D
L
K
T
K
L
-------
A
D
N
L
T
L
N
I
P
I
I
T
A
A
M
D
T
V
T
G
S
K
M
A
I
A
I
A
R
A
G
G
L
G
V
I
H
K
N
M
S
I
T
E
Q
A
E
E
V
R
K
V
K
--
R
S
E
N
G
V
I
I
D
P
F
F
L
T
P
E
H
K
V
S
E
A
E
E
L
M
Q
R
Y
R
I
S
G
V
P
I
V
E
--
T
LA-
N
---
R
K
L
V
G
I
I
T
N
R
D
M
R
F
-
I
S
D
Y
N
A
P
I
S
E
-
H
M
T
-
S
-
E
--
H
L
V
T
-
A
A
V
G
T
D
L
E
---------
T
A
E
R
I
L
H
E
H
-
R
I
E
K
L
P
L
V
D
N
S
G
R
L
S
G
L
I
T
I
K
D
I
E
K
V
I
E
F
P
H
A
A
K
D
E
F
G
R
-
L
L
V
A
A
A
V
G
V
T
S
D
T
F
E
R
A
E
A
L
F
E
A
G
A
D
A
I
V
I
D
T
A
H
G
H
S
A
G
V
L
R
K
I
A
E
I
R
A
H
F
P
-
N
R
T
L
I
A
G
N
I
A
T
A
E
G
A
R
A
L
Y
D
A
G
V
D
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
V
T
A
I
Y
D
A
A
A
V
A
R
E
------
Y
G
K
T
I
I
A
D
G
G
I
K
Y
S
G
D
I
V
K
A
L
A
A
G
G
N
A
V
M
L
G
S
M
F
A
G
T
D
E
A
P
G
E
T
E
I
Y
Q
G
R
K
Y
K
T
Y
R
G
M
G
S
I
A
A
M
K
K
-------------------------
N
K
L
-
V
P
E
G
I
E
G
R
V
A
Y
K
G
A
A
S
D
I
V
F
Q
M
L
G
G
I
R
S
G
M
G
Y
V
G
A
G
D
I
-
Q
E
L
H
E
N
-
A
Q
F
V
E
M
S
G
A
G
L
I
E
S
H
P
H
D
V
Q
I
T
N
E
A
P
N
Y
S
--
11
PsiBlast_PDB
81.03
50%
-87
- C2 -
1ZFJ
1
IMDH_STRPY
A:
[6-489]
--------------------------------------
K
F
L
K
K
G
Y
T
F
D
D
V
L
L
I
P
A
E
S
H
V
L
P
--
N
E
V
D
L
K
T
K
L
-------
A
D
N
L
T
L
N
I
P
I
I
T
A
A
M
D
T
V
T
G
S
K
M
A
I
A
I
A
R
A
G
G
L
G
V
I
H
K
N
M
S
I
T
E
Q
A
E
E
V
R
K
V
K
--
R
S
E
N
G
V
I
I
D
P
F
F
L
T
P
E
H
K
V
S
E
A
E
E
L
M
Q
R
Y
R
I
S
G
V
P
I
V
E
--
T
LA-
N
---
R
K
L
V
G
I
I
T
N
R
D
M
R
F
-
I
S
D
Y
N
A
P
I
S
E
-
H
M
T
-
S
-
E
--
H
L
V
T
-
A
A
V
G
T
D
L
E
---------
T
A
E
R
I
L
H
E
H
-
R
I
E
K
L
P
L
V
D
N
S
G
R
L
S
G
L
I
T
I
K
D
I
E
K
V
I
E
F
P
H
A
A
K
D
E
F
G
R
-
L
L
V
A
A
A
V
G
V
T
S
D
T
F
E
R
A
E
A
L
F
E
A
G
A
D
A
I
V
I
D
T
A
H
G
H
S
A
G
V
L
R
K
I
A
E
I
R
A
H
F
P
N
R
T
-
L
I
A
G
N
I
A
T
A
E
G
A
R
A
L
Y
D
A
G
V
D
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
V
T
A
I
Y
D
A
A
A
V
A
R
E
------
Y
G
K
T
I
I
A
D
G
G
I
K
Y
S
G
D
I
V
K
A
L
A
A
G
G
N
A
V
M
L
G
S
M
F
A
G
T
D
E
A
P
G
E
T
E
I
Y
Q
G
R
K
Y
K
T
Y
R
G
M
G
S
I
A
A
M
K
--
K
-----------------------
N
K
L
-
V
P
E
G
I
E
G
R
V
A
Y
K
G
A
A
S
D
I
V
F
Q
M
L
G
G
I
R
S
G
M
G
Y
V
G
A
G
D
I
-
Q
E
L
H
-
E
N
A
Q
F
V
E
M
S
G
A
G
L
I
E
S
H
P
H
D
V
Q
I
T
N
E
A
P
N
Y
---
7
PsiBlast_PDB
79.39
54%
-95
- C2 -
3TSD
1
?
A:
[29-497]
--------------------------------------
K
F
V
K
E
G
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
--
R
E
V
S
V
K
T
V
L
-------
S
E
S
L
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
M
S
I
E
Q
Q
A
E
Q
V
D
K
V
K
--
R
S
E
S
G
V
I
S
D
P
F
F
L
T
P
E
H
Q
V
Y
D
A
E
H
L
M
G
K
Y
R
I
S
G
V
P
V
V
N
NL
D
---
E
---
R
K
L
V
G
I
I
T
N
R
D
M
R
F
-
I
Q
D
Y
S
I
K
I
S
D
-
V
M
--
K
-
E
--
Q
L
I
T
-
A
P
V
G
T
T
L
S
---------
E
A
E
K
I
L
Q
K
Y
-
K
I
E
K
L
P
L
V
D
N
N
G
V
L
Q
G
L
I
T
I
K
D
I
E
K
V
I
E
F
P
N
S
A
K
D
K
Q
G
R
-
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
-
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
------
R
Q
F
K
V
Y
R
G
-------------------------------------------
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
-
E
F
L
R
-
E
N
A
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
P
---------------
115
HHSearch
78.21
55%
-98
- C2 -
3USB
4
?
A:
[29-493]
--------------------------------------
K
F
V
K
E
G
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
--
R
E
V
S
V
K
T
V
L
-------
S
E
S
L
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
M
S
I
E
Q
Q
A
E
Q
V
D
K
V
K
--
R
S
E
S
G
V
I
S
D
P
F
F
L
T
P
E
H
Q
V
Y
D
A
E
H
L
M
G
K
Y
R
I
S
G
V
P
V
V
N
--
N
LD-
E
---
R
K
L
V
G
I
I
T
N
R
D
M
R
F
-
I
Q
D
Y
S
I
K
I
S
D
-
V
M
T
---
K
E
-
Q
L
I
T
-
A
P
V
G
T
T
L
S
---------
E
A
E
K
I
L
Q
K
Y
-
K
I
E
K
L
P
L
V
D
N
N
G
V
L
Q
G
L
I
T
I
K
D
I
E
K
V
I
E
F
P
N
S
A
K
D
K
Q
G
R
-
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
-------------------------------------------------
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
-
E
F
L
R
E
N
-
A
Q
F
I
R
M
S
G
A
G
L
L
-------------------
9
PsiBlast_PDB
77.34
52%
-98
- C2 -
3USB
4
?
A:
[29-493]
--------------------------------------
K
F
V
K
E
G
L
T
F
D
D
V
L
L
V
P
A
K
S
D
V
L
P
--
R
E
V
S
V
K
T
V
L
-------
S
E
S
L
Q
L
N
I
P
L
I
S
A
G
M
D
T
V
T
E
A
D
M
A
I
A
M
A
R
Q
G
G
L
G
I
I
H
K
N
M
S
I
E
Q
Q
A
E
Q
V
D
K
V
K
--
R
S
E
S
G
V
I
S
D
P
F
F
L
T
P
E
H
Q
V
Y
D
A
E
H
L
M
G
K
Y
R
I
S
G
V
P
V
V
N
NL
D
---
E
---
R
K
L
V
G
I
I
T
N
R
D
M
R
F
-
I
Q
D
Y
S
I
K
I
S
D
-
V
M
T
-
K
-
E
--
Q
L
I
T
-
A
P
V
G
T
T
L
S
---------
E
A
E
K
I
L
Q
K
Y
-
K
I
E
K
L
P
L
V
D
N
N
G
V
L
Q
G
L
I
T
I
K
D
I
E
K
V
I
E
F
P
N
S
A
K
D
K
Q
G
R
-
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
-
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
-------------------------------------------------
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
-
E
F
L
R
-
E
N
A
Q
F
I
R
M
S
G
A
G
L
L
-------------------
14
PsiBlast_PDB
76.86
54%
-106
- C2 -
4DQW
7
?
A:
[23-486]
--------------------------------------
R
I
S
Q
E
A
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
L
P
--
K
D
V
S
L
K
T
R
L
-------
T
R
G
I
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
G
I
E
Q
Q
A
A
E
V
R
K
V
K
--
K
H
E
T
A
I
V
R
D
P
V
T
V
T
P
S
T
K
I
I
E
L
L
Q
M
A
R
E
Y
G
F
S
G
F
P
V
V
E
--
Q
-------
G
E
L
V
G
I
V
T
G
R
D
L
R
V
-
K
P
N
A
G
D
T
V
A
A
-
I
M
T
P
K
-
D
--
K
L
V
T
-
A
R
E
G
T
P
L
E
---------
E
M
K
A
K
L
Y
E
N
-
R
I
E
K
M
L
V
V
D
E
N
F
Y
L
R
G
L
V
T
F
R
D
I
E
K
A
K
T
Y
P
L
A
S
K
D
E
Q
G
R
-
L
R
V
G
A
A
V
G
T
G
A
D
T
G
E
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
D
-
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
L
E
G
------
T
G
V
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
E
-------------------------------------------------------------
P
Y
K
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
-
Q
Q
M
R
T
Q
-
P
Q
F
V
R
I
T
G
-----------------------
26
PsiBlast_CBE
76.73
43%
-93
- C2 -
4Z87
8
?
B:
[38-477]
-------------------------------------------
G
L
T
Y
N
D
F
L
V
L
P
G
K
I
D
F
P
S
--
S
E
V
V
L
S
S
R
L
-------
T
K
K
I
T
L
N
A
P
F
V
S
S
P
M
D
T
V
T
E
A
D
M
A
I
H
M
A
L
L
G
G
I
G
I
I
H
H
N
C
T
A
E
E
Q
A
E
M
V
R
R
V
K
--
K
Y
E
N
G
F
I
N
A
P
V
V
V
G
P
D
A
T
V
A
D
V
R
R
M
K
N
E
F
G
F
A
G
F
P
V
T
D
--
D
GKP
T
---
G
K
L
Q
G
I
I
T
S
R
D
I
Q
F
-
V
E
D
E
T
L
L
V
S
E
-
I
M
T
-
K
----
D
V
I
T
-
G
K
Q
G
I
N
L
E
---------
E
A
N
Q
I
L
K
N
T
-
K
K
G
K
L
P
I
V
D
E
A
G
C
L
V
S
M
L
S
R
T
D
L
M
K
N
Q
S
Y
P
L
A
S
K
S
A
D
T
K
Q
L
L
C
G
A
A
I
G
T
I
D
A
D
R
Q
R
L
A
M
L
V
E
A
G
L
D
V
V
V
L
D
S
S
Q
G
N
S
V
F
Q
I
N
M
I
K
W
I
K
E
T
F
P
D
-
L
Q
V
I
A
G
N
V
V
T
R
E
Q
A
A
S
L
I
H
A
G
A
D
G
L
R
I
G
M
G
S
G
S
I
C
I
T
Q
E
V
M
A
C
G
R
P
Q
G
T
A
V
Y
N
V
T
Q
F
A
N
Q
------
F
G
V
P
C
I
A
D
G
G
V
Q
N
I
G
H
I
T
K
A
I
A
L
G
A
S
T
V
M
M
G
G
M
L
A
G
T
T
E
S
P
G
E
Y
F
F
R
D
G
K
R
L
K
T
Y
R
G
M
G
S
I
D
A
M
Q
------------------------------
V
A
Q
G
V
T
G
S
V
I
D
K
G
S
I
K
K
Y
I
P
Y
L
Y
N
G
L
Q
--------------------------------------------------
25
PsiBlast_CBE
76.72
43%
-94
- C2 -
4Z87
7
?
C:
[38-476]
-------------------------------------------
G
L
T
Y
N
D
F
L
V
L
P
G
K
I
D
F
P
S
--
S
E
V
V
L
S
S
R
L
-------
T
K
K
I
T
L
N
A
P
F
V
S
S
P
M
D
T
V
T
E
A
D
M
A
I
H
M
A
L
L
G
G
I
G
I
I
H
H
N
C
T
A
E
E
Q
A
E
M
V
R
R
V
K
--
K
Y
E
N
G
F
I
N
A
P
V
V
V
G
P
D
A
T
V
A
D
V
R
R
M
K
N
E
F
G
F
A
G
F
P
V
T
D
--
D
GKP----
G
K
L
Q
G
I
I
T
S
R
D
I
Q
F
-
V
E
D
E
T
L
L
V
S
E
-
I
M
T
-
K
----
D
V
I
T
-
G
K
Q
G
I
N
L
E
---------
E
A
N
Q
I
L
K
N
T
-
K
K
G
K
L
P
I
V
D
E
A
G
C
L
V
S
M
L
S
R
T
D
L
M
K
N
Q
S
Y
P
L
A
S
K
S
A
D
T
K
Q
L
L
C
G
A
A
I
G
T
I
D
A
D
R
Q
R
L
A
M
L
V
E
A
G
L
D
V
V
V
L
D
S
S
Q
G
N
S
V
F
Q
I
N
M
I
K
W
I
K
E
T
F
P
D
-
L
Q
V
I
A
G
N
V
V
T
R
E
Q
A
A
S
L
I
H
A
G
A
D
G
L
R
I
G
M
G
S
G
S
I
C
I
T
Q
E
V
M
A
C
G
R
P
Q
G
T
A
V
Y
N
V
T
Q
F
A
N
Q
------
F
G
V
P
C
I
A
D
G
G
V
Q
N
I
G
H
I
T
K
A
I
A
L
G
A
S
T
V
M
M
G
G
M
L
A
G
T
T
E
S
P
G
E
Y
F
F
-
D
G
K
R
L
K
T
Y
R
G
M
G
S
I
D
A
M
Q
---------------------------
V
L
-
V
A
Q
G
V
T
G
S
V
I
D
K
G
S
I
K
K
Y
I
P
Y
L
Y
N
G
L
Q
--------------------------------------------------
30
PsiBlast_CBE
75.95
41%
-95
- C2 -
1NF7
2
IMDH2_HUMAN
B:
[10-476]
----------------
T
S
Y
V
P
D
D
G
L
T
A
Q
Q
L
F
N
C
G
D
--------
G
L
T
Y
N
D
F
L
I
L
P
G
Y
I
D
F
T
A
--
D
Q
V
D
L
T
S
A
L
-------
T
K
K
I
T
L
K
T
P
L
V
S
S
P
M
D
T
V
T
E
A
G
M
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
T
P
E
F
Q
A
N
E
V
R
K
V
K
--
K
Y
E
Q
G
F
I
T
D
P
V
V
L
S
P
K
------------------------------------
G
I
I
S
S
R
D
I
D
F
L--
E
H
D
C
F
L
E
E
-
I
M
T
-
K
R
E
--
D
L
V
V
-
A
P
A
G
I
T
L
K
---------
E
A
N
E
I
L
Q
R
S
-
K
K
G
K
L
P
I
V
N
E
D
D
E
L
V
A
I
I
A
R
T
-
L
K
K
N
R
D
Y
P
L
A
S
K
D
A
K
K
Q
-
L
L
C
G
A
A
I
G
T
H
E
D
D
K
Y
R
L
D
L
L
A
Q
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
I
K
D
K
Y
P
N
-
L
Q
V
I
G
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
S
G
S
I
C
I
T
Q
E
V
L
A
C
G
R
P
Q
A
T
A
V
Y
K
V
S
E
Y
A
R
R
------
F
G
V
P
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
M
M
G
S
L
L
A
A
T
T
E
A
P
G
E
Y
F
F
S
D
G
I
R
L
K
K
Y
R
G
M
G
S
L
D
A
M
-----------------------------
I
K
V
A
Q
G
V
S
G
A
V
Q
D
K
G
S
I
H
K
F
V
P
Y
L
I
A
G
I
Q
H
S
C
Q
D
I
G
A
K
S
L
---------------------------------------
20
PsiBlast_PDB
75.83
41%
-93
- C2 -
1NF7
3
IMDH2_HUMAN
A:
[10-476]
----------------
T
S
Y
V
P
D
D
G
L
T
A
Q
Q
L
F
N
C
G
D
--------
G
L
T
Y
N
D
F
L
I
L
P
G
Y
I
D
F
T
A
--
D
Q
V
D
L
T
S
A
L
-------
T
K
K
I
T
L
K
T
P
L
V
S
S
P
M
D
T
V
T
E
A
G
M
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
T
P
E
F
Q
A
N
E
V
R
K
V
K
--
K
Y
E
Q
G
F
I
T
D
P
V
V
L
S
P
K
------------------------------------
G
I
I
S
S
R
D
I
D
F
L--
E
H
D
C
F
L
E
E
-
I
M
T
-
K
R
E
--
D
L
V
V
-
A
P
A
G
I
T
L
K
---------
E
A
N
E
I
L
Q
R
S
-
K
K
G
K
L
P
I
V
N
E
D
D
E
L
V
A
I
I
A
R
T
-
L
K
K
N
R
D
Y
P
L
A
S
K
D
A
K
K
Q
-
L
L
C
G
A
A
I
G
T
H
E
D
D
K
Y
R
L
D
L
L
A
Q
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
I
K
D
K
Y
P
N
-
L
Q
V
I
G
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
S
G
S
I
C
I
T
Q
E
V
L
A
C
G
R
P
Q
A
T
A
V
Y
K
V
S
E
Y
A
R
R
------
F
G
V
P
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
M
M
G
S
L
L
A
A
T
T
E
A
P
G
E
Y
F
F
S
D
G
I
R
L
K
K
Y
R
G
M
G
S
L
D
A
M
-----------------------------
I
K
V
A
Q
G
V
S
G
A
V
Q
D
K
G
S
I
H
K
F
V
P
Y
L
I
A
G
I
Q
H
S
C
Q
D
I
G
A
K
S
L
---------------------------------------
4
PsiBlast_PDB
74.83
82%
-95
- C2 -
4ZQP
6
?
A:
[68-406]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
S
S
Q
L
T
K
K
I
R
L
-
K
-
V
--
P
L
V
S
S
A
M
D
T
V
T
E
S
R
M
A
I
A
M
A
R
A
G
G
M
G
V
L
H
R
N
-----
L
P
V
A
E
Q
A
G
Q
V
-------
E
M
V
K
----------
R
S
G
G
-
L
L
V
G
A
A
V
G
V
G
G
D
A
W
V
R
A
M
M
L
V
D
A
G
V
D
V
L
V
V
D
T
A
H
A
H
N
R
L
V
L
D
M
V
G
K
L
K
S
E
V
G
D
R
V
E
V
V
G
G
N
V
A
T
R
S
A
A
A
A
L
V
D
A
G
A
D
A
V
K
V
G
V
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
A
P
Q
I
T
A
I
L
E
A
V
A
A
C
R
P
------
A
G
V
P
V
I
A
D
G
G
L
Q
Y
S
G
D
I
A
K
A
L
A
A
G
A
S
T
A
M
L
G
S
L
L
A
G
T
A
E
A
P
G
E
L
I
F
V
N
G
K
Q
Y
K
S
Y
R
G
M
G
S
L
G
A
M
R
---------------------------
K
L
-
V
P
E
G
I
E
G
R
V
P
F
R
G
P
L
S
S
V
I
H
Q
L
T
G
G
L
R
A
A
M
G
Y
T
G
S
P
T
I
-
E
V
L
Q
-
Q
-
A
Q
F
V
R
I
T
P
A
G
L
K
E
S
H
P
H
D
V
A
M
T
V
E
A
P
N
Y
Y
A
-
23
PsiBlast_CBE
74.68
82%
-91
- C2 -
4ZQR
11
?
B:
[68-406]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
S
S
Q
L
T
K
K
I
R
L
-
K
-
V
--
P
L
V
S
S
A
M
D
T
V
T
E
S
R
M
A
I
A
M
A
R
A
G
G
M
G
V
L
H
R
N
-----
L
P
V
A
E
Q
A
G
Q
V
-------
E
M
V
K
----------
R
S
G
G
-
L
L
V
G
A
A
V
G
V
G
G
D
A
W
V
R
A
M
M
L
V
D
A
G
V
D
V
L
V
V
D
T
A
H
A
H
N
R
L
V
L
D
M
V
G
K
L
K
S
E
V
G
D
R
V
E
V
V
G
G
N
V
A
T
R
S
A
A
A
A
L
V
D
A
G
A
D
A
V
K
V
G
V
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
A
P
Q
I
T
A
I
L
E
A
V
A
A
C
R
P
------
A
G
V
P
V
I
A
D
G
G
L
Q
Y
S
G
D
I
A
K
A
L
A
A
G
A
S
T
A
M
L
G
S
L
L
A
G
T
A
E
A
P
G
E
L
I
F
V
N
G
K
Q
Y
K
S
Y
R
G
M
G
S
L
G
A
M
R
-------------------------
E
D
K
L
-
V
P
E
G
I
E
G
R
V
P
F
R
G
P
L
S
S
V
I
H
Q
L
T
G
G
L
R
A
A
M
G
Y
T
G
S
P
T
I
-
E
V
L
Q
-
Q
-
A
Q
F
V
R
I
T
P
A
G
L
K
E
S
H
P
H
D
V
A
M
T
V
E
A
P
N
Y
Y
A
-
24
PsiBlast_CBE
74.51
54%
-110
- C2 -
4DQW
5
?
B:
[23-486]
--------------------------------------
R
I
S
Q
E
A
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
L
P
--
K
D
V
S
L
K
T
R
L
-------
T
R
G
I
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
G
I
E
Q
Q
A
A
E
V
R
K
V
K
--
K
H
E
T
A
I
V
R
D
P
V
T
V
T
P
S
T
K
I
I
E
L
L
Q
M
A
R
E
Y
G
F
S
G
F
P
V
V
E
--
Q
-------
G
E
L
V
G
I
V
T
G
R
D
L
R
V
------
D
T
V
A
A
-
I
M
T
P
K
-
D
--
K
L
V
T
-
A
R
E
G
T
P
L
E
---------
E
M
K
A
K
L
Y
E
N
-
R
I
E
K
M
L
V
V
D
E
N
F
Y
L
R
G
L
V
T
F
R
D
I
E
K
A
K
T
Y
P
L
A
S
K
D
E
Q
G
R
-
L
R
V
G
A
A
V
G
T
G
A
D
T
G
E
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
D
-
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
L
E
G
------
T
G
V
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
-------------------------------------------------------------------
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
-
Q
Q
M
R
T
Q
-
P
Q
F
V
R
I
T
G
-----------------------
5
PsiBlast_PDB
74.49
82%
-91
- C2 -
4ZQR
11
IMDH_MYCTU
A:
[68-406]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
S
S
Q
L
T
K
K
I
R
L
-
K
-
V
--
P
L
V
S
S
A
M
D
T
V
T
E
S
R
M
A
I
A
M
A
R
A
G
G
M
G
V
L
H
R
N
-----
L
P
V
A
E
Q
A
G
Q
V
-------
E
M
V
K
----------
R
S
G
G
-
L
L
V
G
A
A
V
G
V
G
G
D
A
W
V
R
A
M
M
L
V
D
A
G
V
D
V
L
V
V
D
T
A
H
A
H
N
R
L
V
L
D
M
V
G
K
L
K
S
E
V
G
D
R
V
E
V
V
G
G
N
V
A
T
R
S
A
A
A
A
L
V
D
A
G
A
D
A
V
K
V
G
V
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
A
P
Q
I
T
A
I
L
E
A
V
A
A
C
R
P
------
A
G
V
P
V
I
A
D
G
G
L
Q
Y
S
G
D
I
A
K
A
L
A
A
G
A
S
T
A
M
L
G
S
L
L
A
G
T
A
E
A
P
G
E
L
I
F
V
N
G
K
Q
Y
K
S
Y
R
G
M
G
S
L
G
A
M
R
-------------------------
E
D
K
L
-
V
P
E
G
I
E
G
R
V
P
F
R
G
P
L
S
S
V
I
H
Q
L
T
G
G
L
R
A
A
M
G
Y
T
G
S
P
T
I
-
E
V
L
Q
-
Q
-
A
Q
F
V
R
I
T
P
A
G
L
K
E
S
H
P
H
D
V
A
M
T
V
E
A
P
N
Y
Y
A
-
3
PsiBlast_PDB
74.46
82%
-94
- C2 -
4ZQO
5
IMDH_MYCTU
A:
[68-405]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
S
S
Q
L
T
K
K
I
R
L
-
K
-
V
--
P
L
V
S
S
A
M
D
T
V
T
E
S
R
M
A
I
A
M
A
R
A
G
G
M
G
V
L
H
R
N
-----
L
P
V
A
E
Q
A
G
Q
V
-------
E
M
V
K
----------
R
S
G
G
-
L
L
V
G
A
A
V
G
V
G
G
D
A
W
V
R
A
M
M
L
V
D
A
G
V
D
V
L
V
V
D
T
A
H
A
H
N
R
L
V
L
D
M
V
G
K
L
K
S
E
V
G
D
R
V
E
V
V
G
G
N
V
A
T
R
S
A
A
A
A
L
V
D
A
G
A
D
A
V
K
V
G
V
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
A
P
Q
I
T
A
I
L
E
A
V
A
A
C
R
P
------
A
G
V
P
V
I
A
D
G
G
L
Q
Y
S
G
D
I
A
K
A
L
A
A
G
A
S
T
A
M
L
G
S
L
L
A
G
T
A
E
A
P
G
E
L
I
F
V
N
G
K
Q
Y
K
S
Y
R
G
M
G
S
L
G
A
M
R
G
--------------------------
K
L
-
V
P
E
G
I
E
G
R
V
P
F
R
G
P
L
S
S
V
I
H
Q
L
T
G
G
L
R
A
A
M
G
Y
T
G
S
P
T
I
-
E
V
L
Q
-
Q
-
A
Q
F
V
R
I
T
P
A
G
L
K
E
S
H
P
H
D
V
A
M
T
V
E
A
P
N
Y
Y
--
21
PsiBlast_CBE
74.38
82%
-91
- C2 -
4ZQR
12
?
D:
[68-406]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
S
S
Q
L
T
K
K
I
R
L
-
K
-
V
--
P
L
V
S
S
A
M
D
T
V
T
E
S
RMAIAMARA
G
G
M
G
V
L
H
R
N
-----
L
P
V
A
E
Q
A
G
Q
V
-------
E
M
V
K
----------
R
S
G
G
-
L
L
V
G
A
A
V
G
V
G
G
D
A
W
V
R
A
M
M
L
V
D
A
G
V
D
V
L
V
V
D
T
A
H
A
H
N
R
L
V
L
D
M
V
G
K
L
K
S
E
V
G
D
R
V
E
V
V
G
G
N
V
A
T
R
S
A
A
A
A
L
V
D
A
G
A
D
A
V
K
V
G
V
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
A
P
Q
I
T
A
I
L
E
A
V
A
A
C
R
P
------
A
G
V
P
V
I
A
D
G
G
L
Q
Y
S
G
D
I
A
K
A
L
A
A
G
A
S
T
A
M
L
G
S
L
L
A
G
T
A
E
A
P
G
E
L
I
F
V
N
G
K
Q
Y
K
S
Y
R
G
M
G
S
L
G
A
M
R
-------------------------
E
D
K
L
-
V
P
E
G
I
E
G
R
V
P
F
R
G
P
L
S
S
V
I
H
Q
L
T
G
G
L
R
A
A
M
G
Y
T
G
S
P
T
I
-
E
V
L
Q
-
Q
-
A
Q
F
V
R
I
T
P
A
G
L
K
E
S
H
P
H
D
V
A
M
T
V
E
A
P
N
Y
Y
A
-
2
PsiBlast_PDB
73.88
82%
-93
- C2 -
4ZQN
2
?
A:
[68-404]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
S
S
Q
L
T
K
K
I
R
L
-
K
-
V
--
P
L
V
S
S
A
M
D
T
V
T
E
S
R
M
A
I
A
M
A
R
A
G
G
M
G
V
L
H
R
N
-----
L
P
V
A
E
Q
A
G
Q
V
-------
E
M
V
K
----------
R
S
G
G
-
L
L
V
G
A
A
V
G
V
G
G
D
A
W
V
R
A
M
M
L
V
D
A
G
V
D
V
L
V
V
D
T
A
H
A
H
N
R
L
V
L
D
M
V
G
K
L
K
S
E
V
G
D
R
V
E
V
V
G
G
N
V
A
T
R
S
A
A
A
A
L
V
D
A
G
A
D
A
V
K
V
G
V
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
A
P
Q
I
T
A
I
L
E
A
V
A
A
C
R
P
------
A
G
V
P
V
I
A
D
G
G
L
Q
Y
S
G
D
I
A
K
A
L
A
A
G
A
S
T
A
M
L
G
S
L
L
A
G
T
A
E
A
P
G
E
L
I
F
V
N
G
K
Q
Y
K
S
Y
R
G
M
G
S
L
G
A
M
R
--------------------------
D
K
L
-
V
P
E
G
I
E
G
R
V
P
F
R
G
P
L
S
S
V
I
H
Q
L
T
G
G
L
R
A
A
M
G
Y
T
G
S
P
T
I
-
E
V
L
Q
-
Q
-
A
Q
F
V
R
I
T
P
A
G
L
K
E
S
H
P
H
D
V
A
M
T
V
E
A
P
N
Y
---
18
PsiBlast_PDB
73.81
41%
-94
- C2 -
1JR1
3
IMDH2_CRIGR
A:
[17-476]
-----------------------
G
L
T
A
Q
Q
L
F
N
C
G
D
--------
G
L
T
Y
N
D
F
L
I
L
P
G
Y
I
D
F
T
A
--
D
Q
V
D
L
T
S
A
L
-------
T
K
K
I
T
L
K
T
P
L
V
S
S
P
M
D
T
V
T
E
A
G
M
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
T
P
E
F
Q
A
N
E
V
R
K
V
K
--
K
Y
E
Q
G
F
I
T
D
P
V
V
----
D
R
V
R
--
F
E
A
K
-------------------MG-
S
R
L
V
----------------------
I
M
T
-
K
R
E
--
D
L
V
V
-
A
P
A
G
I
T
L
K
---------
E
A
N
E
I
L
Q
R
S
-
K
---
L
P
I
V
N
E
N
D
E
L
V
A
I
I
A
R
T
D
L
K
K
N
R
D
Y
P
L
A
S
K
D
A
K
K
Q
-
L
L
C
G
A
A
I
G
T
H
E
D
D
K
Y
R
L
D
L
L
A
L
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
M
K
E
K
Y
P
N
-
L
Q
V
I
G
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
C
G
S
I
C
I
T
Q
E
V
L
A
C
G
R
P
Q
A
T
A
V
Y
K
V
S
E
Y
A
R
R
------
F
G
V
P
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
M
M
G
S
L
L
A
A
T
T
E
A
P
G
E
Y
F
F
S
D
G
I
R
L
K
K
Y
R
G
M
G
S
L
D
A
M
-----------------------------
I
K
V
A
Q
G
V
S
G
A
V
Q
D
K
G
S
I
H
K
F
V
P
Y
L
I
A
G
I
Q
H
S
C
Q
D
I
G
A
K
S
L
---------------------------------------
1
PsiBlast_PDB
72.29
82%
-100
- C2 -
4ZQM
2
IMDH_MYCTU
A:
[68-387]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
T
S
S
Q
L
T
K
K
I
R
L
-
K
-
V
--
P
L
V
S
S
A
M
D
T
V
T
E
S
R
M
A
I
A
M
A
R
A
G
G
M
G
V
L
H
R
N
-----
L
P
V
A
E
Q
A
G
Q
V
-------
E
M
V
K
----------
R
S
G
G
-
L
L
V
G
A
A
V
G
V
G
G
D
A
W
V
R
A
M
M
L
V
D
A
G
V
D
V
L
V
V
D
T
A
H
A
H
N
R
L
V
L
D
M
V
G
K
L
K
S
E
V
G
D
R
V
E
V
V
G
G
N
V
A
T
R
S
A
A
A
A
L
V
D
A
G
A
D
A
V
K
V
G
V
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
A
P
Q
I
T
A
I
L
E
A
V
A
A
C
R
P
------
A
G
V
P
V
I
A
D
G
G
L
Q
Y
S
G
D
I
A
K
A
L
A
A
G
A
S
T
A
M
L
G
S
L
L
A
G
T
A
E
A
P
G
E
L
I
F
V
N
G
K
Q
Y
K
S
Y
R
G
M
G
S
L
G
A
M
-----------------------------
L
-
V
P
E
G
I
E
G
R
V
P
F
R
G
P
L
S
S
V
I
H
Q
L
T
G
G
L
R
A
A
M
G
Y
T
G
S
P
T
I
-
E
V
L
Q
-
Q
-
A
Q
F
V
R
I
T
P
A
G
L
--------------------
16
PsiBlast_PDB
71.80
50%
-86
- C2 -
2CU0
1
IMDH_PYRHO
A:
[11-480]
----------------------------------------
A
I
K
G
Y
T
F
D
D
V
L
L
I
P
Q
A
T
E
V
E
P
--
K
D
V
D
V
S
T
R
I
-------
T
P
N
V
K
L
N
I
P
I
L
S
A
A
M
D
T
V
T
E
W
E
M
A
V
A
M
A
R
E
G
G
L
G
V
I
H
R
N
M
G
I
E
E
Q
V
E
Q
V
K
R
V
K
--
R
A
E
-------------------------------------------------------------------------------------------------------------------------------------------
K
Y
K
N
A
V
R
D
E
N
G
E
-
L
L
V
A
A
A
V
S
P
F
D
I
K
--
R
A
I
E
L
D
K
A
G
V
D
V
I
V
V
D
T
A
H
A
H
N
L
K
A
I
K
S
M
K
E
M
R
Q
K
V
D
--
A
D
F
I
V
G
N
I
A
N
P
K
A
V
D
D
L
--
T
F
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
T
A
V
A
M
V
A
D
R
A
Q
E
------
Y
G
L
Y
V
I
A
D
G
G
I
R
Y
S
G
D
I
V
K
A
I
A
A
G
A
D
A
V
M
L
G
N
L
L
A
G
T
K
E
A
P
G
K
E
V
I
I
N
G
R
K
Y
K
Q
Y
R
G
M
G
S
L
G
A
M
M
--
K
-------------------
Y
M
K
T
R
K
F
-
V
P
E
G
V
E
G
V
V
P
Y
R
G
T
V
S
E
V
L
Y
Q
L
V
G
G
L
K
A
G
M
G
Y
V
G
A
R
N
I
R
E
L
K
E
-
K
-
G
E
F
V
I
I
T
H
A
G
I
K
E
S
H
P
H
D
I
I
I
T
N
E
A
P
N
----
120
HHSearch
71.37
51%
-86
- C2 -
2CU0
1
IMDH_PYRHO
A:
[11-480]
----------------------------------------
A
I
K
G
Y
T
F
D
D
V
L
L
I
P
Q
A
T
E
V
E
P
--
K
D
V
D
V
S
T
R
I
-------
T
P
N
V
K
L
N
I
P
I
L
S
A
A
M
D
T
V
T
E
W
E
M
A
V
A
M
A
R
E
G
G
L
G
V
I
H
R
N
M
G
I
E
E
Q
V
E
Q
V
K
R
V
K
--
R
A
E
-------------------------------------------------------------------------------------------------------------------------------------------
K
Y
K
N
A
V
R
D
E
N
G
E
-
L
L
V
A
A
A
V
-
S
P
F
D
I
-
K
R
A
I
E
L
D
K
A
G
V
D
V
I
V
V
D
T
A
H
A
H
N
L
K
A
I
K
S
M
K
E
M
R
Q
K
V
--
D
A
D
F
I
V
G
N
I
A
N
P
K
A
V
D
D
L
--
T
F
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
T
A
V
A
M
V
A
D
R
A
Q
E
------
Y
G
L
Y
V
I
A
D
G
G
I
R
Y
S
G
D
I
V
K
A
I
A
A
G
A
D
A
V
M
L
G
N
L
L
A
G
T
K
E
A
P
G
K
E
V
I
I
N
G
R
K
Y
K
Q
Y
R
G
M
G
S
L
G
A
M
M
K
---------------------
Y
M
K
T
R
K
F
-
V
P
E
G
V
E
G
V
V
P
Y
R
G
T
V
S
E
V
L
Y
Q
L
V
G
G
L
K
A
G
M
G
Y
V
G
A
R
N
I
-
R
E
L
K
E
K
-
G
E
F
V
I
I
T
H
A
G
I
K
E
S
H
P
H
D
I
I
I
T
N
E
A
P
N
----
29
PsiBlast_CBE
70.12
41%
-97
- C2 -
1NFB
2
IMDH2_HUMAN
A:
[10-476]
----------------
T
S
Y
V
P
D
D
G
L
T
A
Q
Q
L
F
N
C
G
D
--------
G
L
T
Y
N
D
F
L
I
L
P
G
Y
I
D
F
T
A
--
D
Q
V
D
L
T
S
A
L
-------
T
K
K
I
T
L
K
T
P
L
V
S
S
P
M
D
T
V
T
E
A
G
M
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
T
P
E
F
Q
A
N
E
V
R
K
V
K
--
K
Y
E
Q
G
F
I
T
D
P
V
V
L
S
P
-----------------
G
I
P
I
T
D
--
T
---
G
RMG
S
---------------------------------------
A
P
A
G
I
T
L
K
---------
E
A
N
E
I
L
Q
R
S
-
K
K
G
K
L
P
I
V
N
E
D
D
E
-
V
A
I
I
A
------
N
R
D
Y
P
L
A
S
K
D
A
K
K
Q
-
L
L
C
G
A
A
I
G
T
H
E
D
D
K
Y
R
L
D
L
L
A
Q
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
I
K
D
K
Y
P
N
-
L
Q
V
I
G
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
S
G
S
I
C
I
T
Q
E
V
L
A
C
G
R
P
Q
A
T
A
V
Y
K
V
S
E
Y
A
R
R
------
F
G
V
P
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
M
M
G
S
L
L
A
A
T
T
E
A
P
G
E
Y
F
F
S
D
G
I
R
L
K
K
Y
R
G
M
-----------------------------------------------
D
K
G
S
I
H
K
F
V
P
Y
L
I
A
G
I
Q
H
S
C
Q
D
I
G
A
K
S
L
---------------------------------------
28
PsiBlast_CBE
70.09
41%
-96
- C2 -
1NFB
2
IMDH2_HUMAN
B:
[10-476]
----------------
T
S
Y
V
P
D
D
G
L
T
A
Q
Q
L
F
N
C
G
D
--------
G
L
T
Y
N
D
F
L
I
L
P
G
Y
I
D
F
T
A
--
D
Q
V
D
L
T
S
A
L
-------
T
K
K
I
T
L
K
T
P
L
V
S
S
P
M
D
T
V
T
E
A
G
M
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
T
P
E
F
Q
A
N
E
V
R
K
V
K
--
K
Y
E
Q
G
F
I
T
D
P
V
V
L
S
P
-----------------
G
I
P
I
T
D
--
T
---
G
RMG
S
---------------------------------------
A
P
A
G
I
T
L
K
---------
E
A
N
E
I
L
Q
R
S
-
K
K
G
K
L
P
I
V
N
E
D
D
E
-
V
A
I
I
A
------
N
R
D
Y
P
L
A
S
K
D
A
K
K
Q
-
L
L
C
G
A
A
I
G
T
H
E
D
D
K
Y
R
L
D
L
L
A
Q
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
I
K
D
K
Y
P
N
-
L
Q
V
I
G
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
S
G
S
I
C
I
T
Q
E
V
L
A
C
G
R
P
Q
A
T
A
V
Y
K
V
S
E
Y
A
R
R
------
F
G
V
P
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
M
M
G
S
L
L
A
A
T
T
E
A
P
G
E
Y
F
F
S
D
G
I
R
L
K
K
Y
R
G
M
-----------------------------------------------
D
K
G
S
I
H
K
F
V
P
Y
L
I
A
G
I
Q
H
S
C
Q
D
I
G
A
K
S
L
---------------------------------------
27
PsiBlast_CBE
68.21
41%
-91
- C2 -
1JR1
3
IMDH2_CRIGR
B:
[11-476]
-----------------
S
Y
V
P
D
D
G
L
T
A
Q
Q
L
F
N
C
G
D
--------
G
L
T
Y
N
D
F
L
I
L
P
G
Y
I
D
F
T
A
--
D
Q
V
D
L
T
S
A
L
-------
T
K
K
I
T
L
K
T
P
L
V
S
S
P
M
D
T
V
T
E
A
G
M
A
I
A
M
A
L
T
G
G
I
G
F
I
H
H
N
C
T
P
E
F
Q
A
N
E
V
R
K
V
K
--
K
Y
E
Q
-------------------------------------------------------------------------------------------------------------------------------------------
Y
P
L
A
S
K
D
A
K
K
Q
-
L
L
C
G
A
A
I
G
T
H
E
D
D
K
Y
R
L
D
L
L
A
L
A
G
V
D
V
V
V
L
D
S
S
Q
G
N
S
I
F
Q
I
N
M
I
K
Y
M
K
E
K
Y
P
N
-
L
Q
V
I
G
G
N
V
V
T
A
A
Q
A
K
N
L
I
D
A
G
V
D
A
L
R
V
G
M
G
C
G
S
I
C
I
T
Q
E
V
L
A
C
G
R
P
Q
A
T
A
V
Y
K
V
S
E
Y
A
R
R
------
F
G
V
P
V
I
A
D
G
G
I
Q
N
V
G
H
I
A
K
A
L
A
L
G
A
S
T
V
M
M
G
S
L
L
A
A
T
T
E
A
P
G
E
Y
F
F
S
D
G
I
R
L
K
K
Y
R
G
M
G
S
L
D
A
M
-----------------------------
I
K
V
A
Q
G
V
S
G
A
V
Q
D
K
G
S
I
H
K
F
V
P
Y
L
I
A
G
I
Q
H
S
C
Q
D
I
G
A
K
S
L
---------------------------------------
118
HHSearch
67.43
55%
-105
- C2 -
5AHN
2
?
A:
[6-467]
-----------------------------------------
Q
E
A
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
L
P
--
K
D
V
S
L
K
T
R
L
-------
T
R
G
I
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
G
I
E
Q
Q
A
A
E
V
R
K
V
K
--
K
H
--------------------------------------------------------------------------------------------------------------------------------------------
T
Y
P
L
A
S
K
D
E
Q
G
R
-
L
R
V
G
A
A
V
G
T
G
A
D
T
G
E
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
-
D
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
L
E
G
------
T
G
V
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
-----------------------------------------------------------------
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
-
Q
Q
M
R
T
Q
-
P
Q
F
V
R
I
T
G
A
----------------------
15
PsiBlast_PDB
67.15
54%
-105
- C2 -
5AHN
2
?
A:
[3-467]
--------------------------------------
R
I
S
Q
E
A
L
T
F
D
D
V
L
L
I
P
G
Y
S
E
V
L
P
--
K
D
V
S
L
K
T
R
L
-------
T
R
G
I
E
L
N
I
P
L
V
S
A
A
M
D
T
V
T
E
A
R
L
A
I
A
M
A
Q
E
G
G
I
G
I
I
H
K
N
M
G
I
E
Q
Q
A
A
E
V
R
K
V
K
--
K
H
--------------------------------------------------------------------------------------------------------------------------------------------
T
Y
P
L
A
S
K
D
E
Q
G
R
-
L
R
V
G
A
A
V
G
T
G
A
D
T
G
E
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
D
-
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
L
E
G
------
T
G
V
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
-----------------------------------------------------------------
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
-
Q
Q
M
R
T
Q
-
P
Q
F
V
R
I
T
G
A
----------------------
84
PsiBlast_CBE
66.48
38%
-85
- C2 -
4AF0
2
?
B:
[59-523]
-------------------------------------------
G
L
T
Y
N
D
F
L
V
L
P
G
H
I
N
F
P
A
--
S
D
V
S
L
Q
S
K
A
-------
T
K
N
I
V
L
N
T
P
F
L
S
S
P
M
D
T
V
T
E
D
R
M
A
I
A
L
A
L
H
G
G
L
G
I
I
H
H
N
C
S
A
E
E
Q
A
A
M
V
R
R
V
K
--
K
Y
E
N
-------------------------------------------------------------------------------------------------------------------------------------------
Y
P
Y
A
S
K
V
P
E
S
K
Q
L
Y
C
G
A
A
I
G
T
R
P
G
D
K
D
R
L
K
L
L
A
E
A
G
L
D
V
V
V
L
D
S
S
Q
G
N
S
V
Y
Q
I
E
F
I
K
W
I
K
-
Q
T
Y
P
K
I
D
V
I
A
G
N
V
V
T
R
E
Q
A
A
Q
L
I
A
A
G
A
D
G
L
R
I
G
M
G
S
G
S
I
C
I
T
Q
E
V
M
A
V
G
R
P
Q
G
T
A
V
Y
A
V
A
E
F
A
S
R
------
F
G
I
P
C
I
A
D
G
G
I
G
N
I
G
H
I
A
K
A
L
A
L
G
A
S
A
V
M
M
G
G
L
L
A
G
T
T
E
S
P
G
E
Y
F
Y
H
E
G
K
R
V
K
V
Y
R
G
M
G
S
I
E
A
M
E
H
T-----GLD
N
A
A
T
A
R
Y
F
S
E
A
D
A
V
K
-----
V
A
Q
G
V
S
G
D
V
A
D
K
G
S
I
N
K
F
V
P
Y
L
F
T
G
L
Q
H
S
L
Q
D
A
G
I
K
S
V
-
S
E
L
H
-
S
-
C
------------------------------
119
HHSearch
64.92
32%
-87
- C2 -
1ME8
3
IMDH_TRIFO
A:
[7-492]
-----------------------------------------
E
P
C
H
T
F
N
E
Y
L
L
I
P
G
L
S
T
V
D
C
IP
S
N
V
N
L
S
T
P
L
V
K
F
Q
KGQ
Q
S
E
I
N
L
K
I
P
L
V
S
A
I
M
Q
S
V
S
G
E
K
M
A
I
A
L
A
R
E
G
G
I
S
F
I
F
G
S
Q
S
I
E
S
Q
A
A
M
V
H
A
V
K
N
F
K
A
----------------------------------------------------------------------------------------------------------------------------------------------
H
N
E
L
V
D
S
Q
K
R
-
Y
L
V
G
A
G
I
N
T
R
-
D
F
R
E
R
V
P
A
L
V
E
A
G
A
D
V
L
C
I
D
S
S
D
G
F
S
E
W
Q
K
I
T
I
G
W
I
R
E
K
Y
G
D
K
V
K
V
G
A
G
N
I
V
D
G
E
G
F
R
Y
L
A
D
A
G
A
D
F
I
K
I
G
I
G
G
G
S
I
C
I
T
R
E
Q
K
G
I
G
R
G
Q
A
T
A
V
I
D
V
V
A
E
R
N
K
Y
F
E
ET
G
I
Y
I
P
V
C
S
D
G
G
I
V
Y
D
Y
H
M
T
L
A
L
A
M
G
A
D
F
I
M
L
G
R
Y
F
A
R
F
E
E
S
P
T
R
K
V
T
I
N
G
S
V
M
K
E
Y
W
G
E
G
S
S
R
A
R
N
W
-------------------------------
E
G
V
D
S
Y
V
P
Y
A
G
K
L
K
D
N
V
E
A
S
L
N
K
V
K
S
T
M
C
N
C
G
A
L
T
I
-
P
Q
L
Q
S
K
-
A
K
I
T
L
V
S
S
V
S
I
V
E
G
G
A
H
D
V
I
-----------
85
PsiBlast_CBE
64.66
38%
-86
- C2 -
4AF0
2
?
A:
[59-509]
-------------------------------------------
G
L
T
Y
N
D
F
L
V
L
P
G
H
I
N
F
P
A
--
S
D
V
S
L
Q
S
K
A
-------
T
K
N
I
V
L
N
T
P
F
L
S
S
P
M
D
T
V
T
E
D
R
M
A
I
A
L
A
L
H
G
G
L
G
I
I
H
H
N
C
S
A
E
E
Q
A
A
M
V
R
R
V
K
--
K
Y
E
N
-------------------------------------------------------------------------------------------------------------------------------------------
Y
P
Y
A
S
K
V
P
E
S
K
Q
L
Y
C
G
A
A
I
G
T
R
P
G
D
K
D
R
L
K
L
L
A
E
A
G
L
D
V
V
V
L
D
S
S
Q
G
N
S
V
Y
Q
I
E
F
I
K
W
I
K
-
Q
T
Y
P
K
I
D
V
I
A
G
N
V
V
T
R
E
Q
A
A
Q
L
I
A
A
G
A
D
G
L
R
I
G
M
G
S
G
S
I
C
I
T
Q
E
V
M
A
V
G
R
P
Q
G
T
A
V
Y
A
V
A
E
F
A
S
R
------
F
G
I
P
C
I
A
D
G
G
I
G
N
I
G
H
I
A
K
A
L
A
L
G
A
S
A
V
M
M
G
G
L
L
A
G
T
T
E
S
P
G
E
Y
F
Y
H
E
G
K
R
V
K
V
Y
R
G
M
G
S
I
E
A
M
E
H
T-----GLD
N
A
A
T
A
R
Y
F
S
E
A
D
A
V
K
-----
V
A
Q
G
V
S
G
D
V
A
D
K
G
S
I
N
K
F
V
P
Y
L
F
T
G
L
Q
H
S
L
-----------------------------------------------
82
PsiBlast_CBE
62.92
61%
-98
- C2 -
5AHM
3
?
A:
[113-397]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
A
K
T
Y
P
L
A
S
K
D
E
Q
G
R
-
L
R
V
G
A
A
V
G
T
G
A
D
T
G
E
R
V
A
A
L
V
A
A
G
V
D
V
V
V
V
D
T
A
H
G
H
S
K
G
V
I
E
R
V
R
W
V
K
Q
T
F
P
D
-
V
Q
V
I
G
G
N
I
A
T
A
E
A
A
K
A
L
A
E
A
G
A
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
A
G
V
G
V
P
Q
I
S
A
I
A
N
V
A
A
A
L
E
G
------
T
G
V
P
L
I
A
D
G
G
I
R
F
S
G
D
L
A
K
A
M
V
A
G
A
Y
C
V
M
M
G
S
M
F
A
G
T
E
E
A
P
G
E
I
E
L
F
Q
G
R
S
Y
K
S
Y
R
G
M
G
S
L
----------------------------------
V
P
E
G
I
E
G
R
V
P
Y
K
G
A
L
S
A
I
V
H
Q
L
M
G
G
L
R
A
A
M
G
Y
T
G
S
A
D
I
-
Q
Q
M
R
T
Q
-
P
Q
F
V
R
I
T
G
A
G
M
A
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
---
81
PsiBlast_CBE
60.48
57%
-97
- C2 -
4FO4
3
?
A:
[95-363]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
-
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
-
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
-------
S
--------------------
K
L
-
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
-
E
D
L
R
T
K
-
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
---
80
PsiBlast_CBE
60.43
57%
-97
- C2 -
4FO4
3
?
B:
[95-363]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
-
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
-
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
-------
S
--------------------
K
L
-
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
-
E
D
L
R
T
K
-
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
---
132
HHSearch
60.15
62%
-95
- C2 -
4R7J
6
?
A:
[128-381]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
R
V
D
A
L
V
E
A
G
V
D
V
V
V
L
D
S
A
H
G
H
S
K
G
I
I
D
T
V
K
A
I
K
A
K
Y
P
-
N
L
D
L
I
A
G
N
I
A
T
A
A
A
A
K
A
L
C
E
A
G
V
D
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
S
G
V
G
V
P
Q
I
S
A
I
D
E
C
V
E
E
A
N
K
------
F
G
V
P
V
I
A
D
G
G
I
K
Y
S
G
D
I
A
K
A
L
A
V
G
A
S
S
V
M
I
G
S
L
L
A
G
T
D
E
S
P
G
E
L
F
T
Y
Q
G
R
Q
Y
K
S
Y
R
G
M
G
S
L
G
A
M
Q
K
---------------------------
L
-
V
P
E
G
I
E
G
R
V
P
Y
V
G
S
I
R
S
V
V
H
Q
L
L
G
G
L
R
S
S
M
G
Y
V
G
A
K
D
I
-
E
D
F
Q
K
R
-
A
E
F
V
E
I
T
T
A
G
L
K
E
S
H
V
H
D
V
T
I
T
H
E
A
P
N
Y
K
--
71
PsiBlast_CBE
60.14
57%
-97
- C2 -
4X3Z
3
?
B:
[95-363]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
-
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
-
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
-------
S
--------------------
K
L
-
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
-
E
D
L
R
T
K
-
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
---
72
PsiBlast_CBE
60.05
57%
-96
- C2 -
4X3Z
4
?
A:
[95-363]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
-
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
-
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
-------
S
---------------------
L
-
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
-
E
D
L
R
T
K
-
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
---
49
PsiBlast_CBE
60.03
57%
-102
- C2 -
4MYA
3
?
B:
[116-382]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
-
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
-
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
--
K
------------------------
K
L
-
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
-
E
F
L
R
-
E
N
A
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
P
H
H
V
Q
I
T
K
E
A
P
N
Y
---
61
PsiBlast_CBE
60.02
57%
-104
- C2 -
4MY8
7
?
B:
[116-366]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
-
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
-
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
--
K
-------------------------
L
-
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
-
E
F
L
R
-
E
N
A
Q
F
I
R
M
S
G
A
G
L
L
-------------------
39
PsiBlast_CBE
59.83
57%
-105
- C2 -
4QM1
3
?
B:
[116-382]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
-
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
-
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
--
K
------------------------
K
L
-
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
-
E
F
L
R
-
E
N
A
Q
F
I
R
M
S
G
A
G
L
L
-----
H
V
Q
I
T
K
E
A
P
N
Y
---
50
PsiBlast_CBE
59.77
57%
-99
- C2 -
4MYA
4
?
A:
[116-382]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
-
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
-
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
--
K
-----------------------
K
K
L
-
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
-
E
F
L
R
-
E
N
A
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
P
H
H
V
Q
I
T
K
E
A
P
N
Y
---
76
PsiBlast_CBE
59.73
57%
-100
- C2 -
4IX2
3
?
D:
[95-363]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
-
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
-
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
--------------------------------------
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
-
E
D
L
R
T
K
-
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
---
75
PsiBlast_CBE
59.42
57%
-94
- C2 -
4QNE
3
?
A:
[95-363]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
-
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
-
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
-------
S
---------------------
L
-
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
-
E
D
L
R
T
K
-
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
---
62
PsiBlast_CBE
59.37
57%
-101
- C2 -
4MY8
9
?
A:
[116-367]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
-
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
-
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
--
K
G
--------
S
K
--------------
L
-
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
-
E
F
L
R
-
E
N
A
Q
F
I
R
M
S
G
A
G
L
L
E
------------------
74
PsiBlast_CBE
59.23
57%
-97
- C2 -
4QNE
3
?
B:
[95-363]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
-
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
-
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
-------
S
---------------------
L
-
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
-
E
D
L
R
T
K
-
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
---
60
PsiBlast_CBE
59.21
57%
-107
- C2 -
4MY8
4
?
C:
[116-366]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
-
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
-
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
--
K
------------------------
K
L
-
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
-
E
F
L
R
-
E
N
A
Q
F
I
R
M
S
G
A
G
L
L
-------------------
77
PsiBlast_CBE
59.14
57%
-99
- C2 -
4IX2
3
?
C:
[95-363]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
-
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
-
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
--------------------------------------
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
-
E
D
L
R
T
K
-
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
---
35
PsiBlast_CBE
59.08
53%
-92
- C2 -
4FEZ
5
?
B:
[67-366]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
E
G
--------------
G
I
G
F
I
H
K
N
M
S
I
E
Q
Q
A
A
Q
V
H
Q
V
K
I
F
E
S
-----------
K
P
N
A
C
K
D
E
Q
G
R
-
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
-
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
----------------------------------------------
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
-
E
D
L
R
T
K
-
A
Q
F
V
R
I
S
G
A
----------------------
79
PsiBlast_CBE
58.98
57%
-97
- C2 -
4IX2
2
?
A:
[95-363]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
-
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
-
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
--------------------------------------
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
-
E
D
L
R
T
K
-
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
---
78
PsiBlast_CBE
58.60
57%
-93
- C2 -
4IX2
2
?
B:
[95-363]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
-
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
-
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
--------------------------------------
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
-
E
D
L
R
T
K
-
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
---
40
PsiBlast_CBE
58.54
57%
-103
- C2 -
4QM1
3
?
A:
[116-376]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
-
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
-
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
--
K
---------------------------
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
-
E
F
L
R
-
E
N
A
Q
F
I
R
M
S
G
A
G
L
L
------
V
Q
I
T
---------
37
PsiBlast_CBE
58.42
57%
-99
- C2 -
4QM1
3
?
D:
[116-376]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
-
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
-
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
----------------------------
L
-
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
-
E
F
L
R
-
E
N
A
Q
F
I
R
M
S
G
A
G
L
L
E
S
----
V
Q
I
T
---------
129
HHSearch
58.13
59%
-92
- C2 -
4X3Z
4
?
A:
[112-363]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
P
-
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
G
M
G
S
L
G
A
M
S
----------------------------
L
-
V
P
E
G
I
E
G
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
-
E
D
L
R
T
K
-
A
Q
F
V
R
I
S
G
A
G
M
K
E
S
H
V
H
D
V
Q
I
T
K
E
A
P
N
Y
---
38
PsiBlast_CBE
57.89
57%
-104
- C2 -
4QM1
3
?
C:
[116-375]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
-
L
L
V
G
A
A
V
G
V
T
A
D
A
M
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
-
P
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
-------------------------------
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
-
E
F
L
R
-
E
N
A
Q
F
I
R
M
S
G
A
G
L
L
------
V
Q
I
----------
36
PsiBlast_CBE
57.75
53%
-93
- C2 -
4FEZ
6
?
A:
[67-366]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Q
E
G
--------------
G
I
G
F
I
H
K
N
M
S
I
E
Q
Q
A
A
Q
V
H
Q
V
K
I
F
E
S
-----------
K
P
N
A
C
K
D
E
Q
G
R
-
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
-
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
G
E
V
I
L
Y
Q
G
R
S
Y
K
A
Y
R
-----------------------------------------------
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
-
E
D
L
R
T
K
-
A
Q
F
V
R
I
S
G
A
----------------------
130
HHSearch
56.98
58%
-93
- C2 -
4MYA
4
?
A:
[132-382]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
R
I
D
A
L
V
K
A
S
V
D
A
I
V
L
D
T
A
H
G
H
S
Q
G
V
I
D
K
V
K
E
V
R
A
K
Y
P
-
S
L
N
I
I
A
G
N
V
A
T
A
E
A
T
K
A
L
I
E
A
G
A
N
V
V
K
V
G
I
G
P
G
S
I
C
T
T
R
V
V
A
G
V
G
V
P
Q
L
T
A
V
Y
D
C
A
T
E
A
R
K
------
H
G
I
P
V
I
A
D
G
G
I
K
Y
S
G
D
M
V
K
A
L
A
A
G
A
H
V
V
M
L
G
S
M
F
A
G
V
A
E
S
P
G
E
T
E
I
Y
Q
G
R
Q
F
K
V
Y
R
G
M
G
S
V
G
A
M
E
K
-------------------------
K
K
L
-
V
P
E
G
I
E
G
R
V
P
Y
K
G
P
L
A
D
T
V
H
Q
L
V
G
G
L
R
A
G
M
G
Y
C
G
A
Q
D
L
-
E
F
L
R
E
N
-
A
Q
F
I
R
M
S
G
A
G
L
L
E
S
H
P
H
H
V
Q
I
T
K
E
A
P
N
Y
---
73
PsiBlast_CBE
56.93
57%
-112
- C2 -
4QQ3
3
?
A:
[95-344]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
-
L
R
V
G
A
A
V
G
A
A
P
G
N
E
E
R
V
K
A
L
V
E
A
G
V
D
V
L
L
I
D
S
S
H
G
H
S
E
G
V
L
Q
R
I
R
E
T
R
A
A
Y
-
P
H
L
E
I
I
G
G
N
V
A
T
A
E
G
A
R
A
L
I
E
A
G
V
S
A
V
K
V
G
I
G
P
G
S
I
C
T
T
R
I
V
T
G
V
G
V
P
Q
I
T
A
I
A
D
A
A
G
V
A
N
E
------
Y
G
I
P
V
I
A
D
G
G
I
R
F
S
G
D
I
S
K
A
I
A
A
G
A
S
C
V
M
V
G
S
M
F
A
G
T
E
E
A
P
-------
G
R
S
Y
K
A
Y
R
G
M
G
-------------------------------------------
R
I
A
Y
K
G
H
L
K
E
I
I
H
Q
Q
M
G
G
L
R
S
C
M
G
L
T
G
S
A
T
V
-
E
D
L
R
T
K
-
A
Q
F
V
R
I
S
G
A
----------------------