@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3433c: (2016-05-20 )
MRHYYSVDTIRAAEAPLLASLPDGALMRRAAFGLATEIGRELTARTGGVVGRRVCAVVGSGDNGGDALWAATFLRRRGAAADAVLLNPDRTHRKALAAFTKSGGRLVESVSAATDLVIDGVVGISGSGPLRPAAAQVFAAVQAAAIPVVAVDIPSGIDVATGAITGPAVHAALTVTFGGLKPVHALADCGRVVLVDIGLDLAHTDVLGFEATDVAARWPVPGPRDDKYTQGVTGVLAGSSTYPGAAVLCTGAAVAATSGMVRYAGTAHAEVLAHWPEVIASPTPAAAGRVQAWVVGPGLGTDEAGAAALWFALDTDLPVLVDADGLTMLADHPDLVAGRNAPTVLTPHAGEFARLAGAPPGDDRVGACRQLADALGATVLLKGNVTVIADPGGPVYLNPAGQSWAATAGSGDVLSGMIGALLASGLPSGEAAAAAAFVHARASAAAAADPGPGDAPTSASRISGHIRAALAAL
Atome Classification :
(31 SA)
.........10.......--.20........30........40........50........60........70........80.......--.90........100......----.110.......120.......130.......140.......150.......160.......170.......180.....----.----.190.......200...---...-.210.......220-....-...230.......240.......250.......260.......--270.--......280..-------.---------------...---------------.290.......300.......310...-....320.......330.......340.......350.......360-..---.....--..370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
R
H
Y
Y
SVDTIRAAEAP
L
L
--ASLP
D
G
A
L
M
R
R
A
A
F
G
L
A
T
E
I
G
R
E
L
T
A
RTG
G
V
VG
R
R
V
C
A
V
VGSGDNG
G
D
A
L
W
A
A
T
F
L
R
RRGAAA
D
A
V
L
LNP--
D
R
T
H
R
K
A
L
A
A
F
T
KSG
G
R
L
V
E
----
S
V
SAA
T
D
L
V
I
D
G
V
VGISGSGPL
R
P
A
A
A
Q
V
F
A
A
V
Q
AAA
I
P
V
V
A
V
DIPSGIDVATGAITGP
A
V
H
A
A
L
T
V
T
FGGL
K
P
V
H
A
L
A----D----CG
R
V
V
L
V
DIGLDLAHTD---VLG-FEATDVAARWPVPG-PRDD-KYTQGV
T
G
V
LAGSSTYPG
A
A
V
L
CTG
A
A
V
A
ATSG
M
V
R
YAG
T
A
H
A
--
E
V
L
A
--
H
W
P
E
V
IASPTP-------A---------------AAG---------------
R
V
Q
A
W
V
VGPGLGTDEAG
A
A
A
L
W
F
A
LDT-DL
P
V
L
VDAD
G
L
T
MLADHPDLVAGRNA
P
T
V
LTPHAG
E
F
A
R
LAGAPP---GD---
D
R
V
G
A
--
C
R
Q
L
A
D
ALG
A
T
V
L
LKG
N
V
T
V
I
ADPGG
P
V
Y
LNPAGQSWAATAGS
G
D
V
L
S
G
M
I
G
A
L
L
ASGLPS
G
E
A
A
A
A
A
A
F
V
H
ARASAAAAADPGPGDAPT
S
A
S
R
I
S
G
H
I
R
A
A
L
AAL
32
HHSearch
97.87
29%
-108
* C3 *
3RSS
3
NNR_THEMA
A:
[11-500]
-------
H
H
M
K
E
I
D
E
L
T
I
KE
Y
G
V
D
S
R
I
L
M
E
R
A
G
I
S
V
V
L
A
M
E
E
E
L
G
N
----
L
S
D
Y
R
F
L
V
L
C
G
G
G
N
N
G
G
D
G
F
V
V
A
R
N
L
L
G
V
V
K
D
V
L
V
V
F
L
G
K
KK
T
P
D
C
E
Y
N
Y
G
L
Y
K
K
F
G
G
K
V
V
E
QFEP
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
P
G
R
D
L
----
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
SIN
R
Y
V
-
I
T
R
E
M
V
R
S
L
L
P
E
R
P
-
R
D
S
H
-
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
N
L
I
A
T
S
--
R
F
P
E
L
I
S
V
P
I
D
-------
T
EKGFFSLQN
L
Q
E
C
L
E
L
S
K
---------------
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
D
T
S
-
V
L
-
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
GD-
V
K
---
Y
N
Y
E
L
--
A
E
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
G
-
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
-
D
E
---
R
G
L
T
A
S
E
L
L
R
L
I
P
E
A
I
R
R
L
7
PsiBlast_PDB
85.08
30%
-105
- C3 -
3RT9
6
NNR_THEMA
A:
[93-480]
-----------------------------------------------------------------------------------------
P
--
D
C
E
Y
N
Y
G
L
--
Y
K
K
F
G
G
K
V
V
E
QFEP
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
----
P
G
R
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
---
S
I
N
R
Y
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
--
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
-------
T
---------------
E
K
G
FFSLQN
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
--
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
---
G
D
---
V
K
Y
N
Y
E
L
A
E
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
-
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
------------------------
3
PsiBlast_PDB
85.02
30%
-106
- C3 -
3RSF
3
NNR_THEMA
A:
[93-480]
-----------------------------------------------------------------------------------------
P
--
D
C
E
Y
N
Y
G
L
--
Y
K
K
F
G
G
K
V
V
E
QFEP
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
----
P
G
R
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
---
S
I
N
R
Y
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
--
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
-------
T
---------------
E
K
G
FFSLQN
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
--
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
---
G
D
---
V
K
Y
N
Y
E
L
A
E
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
-
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
------------------------
1
PsiBlast_PDB
84.96
30%
-103
- C3 -
3RS8
7
NNR_THEMA
A:
[93-480]
-----------------------------------------------------------------------------------------
P
--
D
C
E
Y
N
Y
G
L
--
Y
K
K
F
G
G
K
V
V
E
QFEP
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
----
P
G
R
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
---
S
I
N
R
Y
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
--
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
-------
T
---------------
E
K
G
FFSLQN
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
--
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
---
G
D
---
V
K
Y
N
Y
E
L
A
E
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
-
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
------------------------
14
PsiBlast_PDB
84.89
30%
-103
- C3 -
3RRB
4
NNR_THEMA
A:
[93-480]
-----------------------------------------------------------------------------------------
P
--
D
C
E
Y
N
Y
G
L
--
Y
K
K
F
G
G
K
V
V
E
QFEP
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
----
P
G
R
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
---
S
I
N
R
Y
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
--
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
-------
T
---------------
E
K
G
FFSLQN
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
--
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
---
G
D
---
V
K
Y
N
Y
E
L
A
E
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
-
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
------------------------
5
PsiBlast_PDB
84.71
30%
-105
- C3 -
3RSS
3
NNR_THEMA
A:
[93-480]
-----------------------------------------------------------------------------------------
P
--
D
C
E
Y
N
Y
G
L
--
Y
K
K
F
G
G
K
V
V
E
QFEP
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
----
P
G
R
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
---
S
I
N
R
Y
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
--
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
-------
T
---------------
E
K
G
FFSLQN
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
--
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
---
G
D
---
V
K
Y
N
Y
E
L
A
E
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
-
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
------------------------
19
PsiBlast_PDB
84.67
30%
-104
- C3 -
3RTB
4
NNR_THEMA
A:
[93-480]
-----------------------------------------------------------------------------------------
P
--
D
C
E
Y
N
Y
G
L
--
Y
K
K
F
G
G
K
V
V
E
QFEP
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
----
P
G
R
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
---
S
I
N
R
Y
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
--
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
-------
T
---------------
E
K
G
FFSLQN
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
--
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
---
G
D
---
V
K
Y
N
Y
E
L
A
E
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
-
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
------------------------
16
PsiBlast_PDB
84.61
30%
-104
- C3 -
3RRF
6
NNR_THEMA
A:
[93-480]
-----------------------------------------------------------------------------------------
P
--
D
C
E
Y
N
Y
G
L
--
Y
K
K
F
G
G
K
V
V
E
QFEP
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
----
P
G
R
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
---
S
I
N
R
Y
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
--
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
-------
T
---------------
E
K
G
FFSLQN
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
--
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
---
G
D
---
V
K
Y
N
Y
E
L
A
E
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
-
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
------------------------
10
PsiBlast_PDB
84.52
30%
-104
- C3 -
3RTD
6
NNR_THEMA
A:
[93-480]
-----------------------------------------------------------------------------------------
P
--
D
C
E
Y
N
Y
G
L
--
Y
K
K
F
G
G
K
V
V
E
QFEP
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
----
P
G
R
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
---
S
I
N
R
Y
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
--
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
-------
T
---------------
E
K
G
FFSLQN
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
--
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
---
G
D
---
V
K
Y
N
Y
E
L
A
E
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
-
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
------------------------
8
PsiBlast_PDB
84.52
30%
-105
- C3 -
3RTA
4
NNR_THEMA
A:
[93-480]
-----------------------------------------------------------------------------------------
P
--
D
C
E
Y
N
Y
G
L
--
Y
K
K
F
G
G
K
V
V
E
QFEP
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
----
P
G
R
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
---
S
I
N
R
Y
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
--
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
-------
T
---------------
E
K
G
FFSLQN
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
--
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
---
G
D
---
V
K
Y
N
Y
E
L
A
E
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
-
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
------------------------
12
PsiBlast_PDB
84.51
30%
-104
- C3 -
3RTG
7
NNR_THEMA
A:
[93-480]
-----------------------------------------------------------------------------------------
P
--
D
C
E
Y
N
Y
G
L
--
Y
K
K
F
G
G
K
V
V
E
QFEP
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
----
P
G
R
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
---
S
I
N
R
Y
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
--
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
-------
T
---------------
E
K
G
FFSLQN
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
--
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
---
G
D
---
V
K
Y
N
Y
E
L
A
E
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
-
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
------------------------
18
PsiBlast_PDB
84.47
30%
-103
- C3 -
3RSG
6
NNR_THEMA
A:
[93-480]
-----------------------------------------------------------------------------------------
P
--
D
C
E
Y
N
Y
G
L
--
Y
K
K
F
G
G
K
V
V
E
QFEP
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
----
P
G
R
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
---
S
I
N
R
Y
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
--
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
-------
T
---------------
E
K
G
FFSLQN
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
--
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
---
G
D
---
V
K
Y
N
Y
E
L
A
E
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
-
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
------------------------
4
PsiBlast_PDB
84.36
30%
-105
- C3 -
3RSQ
4
NNR_THEMA
A:
[93-480]
-----------------------------------------------------------------------------------------
P
--
D
C
E
Y
N
Y
G
L
--
Y
K
K
F
G
G
K
V
V
E
QFEP
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
----
P
G
R
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
---
S
I
N
R
Y
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
--
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
-------
T
---------------
E
K
G
FFSLQN
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
--
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
---
G
D
---
V
K
Y
N
Y
E
L
A
E
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
-
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
------------------------
2
PsiBlast_PDB
84.31
30%
-105
- C3 -
3RS9
6
NNR_THEMA
A:
[93-480]
-----------------------------------------------------------------------------------------
P
--
D
C
E
Y
N
Y
G
L
--
Y
K
K
F
G
G
K
V
V
E
QFEP
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
----
P
G
R
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
---
S
I
N
R
Y
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
--
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
-------
T
---------------
E
K
G
FFSLQN
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
--
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
---
G
D
---
V
K
Y
N
Y
E
L
A
E
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
-
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
------------------------
6
PsiBlast_PDB
84.29
30%
-103
- C3 -
3RT7
7
NNR_THEMA
A:
[93-480]
-----------------------------------------------------------------------------------------
P
--
D
C
E
Y
N
Y
G
L
--
Y
K
K
F
G
G
K
V
V
E
QFEP
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
----
P
G
R
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
---
S
I
N
R
Y
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
--
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
-------
T
---------------
E
K
G
FFSLQN
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
--
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
---
G
D
---
V
K
Y
N
Y
E
L
A
E
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
-
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
------------------------
11
PsiBlast_PDB
84.26
30%
-105
- C3 -
3RTE
6
NNR_THEMA
A:
[93-480]
-----------------------------------------------------------------------------------------
P
--
D
C
E
Y
N
Y
G
L
--
Y
K
K
F
G
G
K
V
V
E
QFEP
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
----
P
G
R
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
---
S
I
N
R
Y
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
--
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
-------
T
---------------
E
K
G
FFSLQN
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
--
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
---
G
D
---
V
K
Y
N
Y
E
L
A
E
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
-
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
------------------------
17
PsiBlast_PDB
84.19
30%
-106
- C3 -
3RRJ
4
NNR_THEMA
A:
[93-480]
-----------------------------------------------------------------------------------------
P
--
D
C
E
Y
N
Y
G
L
--
Y
K
K
F
G
G
K
V
V
E
QFEP
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
----
P
G
R
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
---
S
I
N
R
Y
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
--
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
-------
T
---------------
E
K
G
FFSLQN
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
--
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
---
G
D
---
V
K
Y
N
Y
E
L
A
E
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
-
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
------------------------
15
PsiBlast_PDB
84.18
30%
-105
- C3 -
3RRE
6
NNR_THEMA
A:
[93-480]
-----------------------------------------------------------------------------------------
P
--
D
C
E
Y
N
Y
G
L
--
Y
K
K
F
G
G
K
V
V
E
QFEP
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
----
P
G
R
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
---
S
I
N
R
Y
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
--
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
-------
T
---------------
E
K
G
FFSLQN
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
--
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
---
G
D
---
V
K
Y
N
Y
E
L
A
E
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
-
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
------------------------
9
PsiBlast_PDB
83.90
30%
-105
- C3 -
3RTC
6
NNR_THEMA
A:
[93-480]
-----------------------------------------------------------------------------------------
P
--
D
C
E
Y
N
Y
G
L
--
Y
K
K
F
G
G
K
V
V
E
QFEP
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
----
P
G
R
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
---
S
I
N
R
Y
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
--
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
-------
T
---------------
E
K
G
FFSLQN
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
--
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
---
G
D
---
V
K
Y
N
Y
E
L
A
E
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
-
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
------------------------
20
PsiBlast_PDB
83.48
30%
-105
- C3 -
3RU2
4
NNR_THEMA
A:
[93-480]
-----------------------------------------------------------------------------------------
P
--
D
C
E
Y
N
Y
G
L
--
Y
K
K
F
G
G
K
V
V
E
QFEP
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
----
P
G
R
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
---
S
I
N
R
Y
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
--
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
-------
T
---------------
E
K
G
FFSLQN
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
--
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
---
G
D
---
V
K
Y
N
Y
E
L
A
E
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
-
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
------------------------
13
PsiBlast_PDB
83.41
30%
-102
- C3 -
3RU3
5
NNR_THEMA
A:
[93-480]
-----------------------------------------------------------------------------------------
P
--
D
C
E
Y
N
Y
G
L
--
Y
K
K
F
G
G
K
V
V
E
QFEP
S
I
L
N
E
F
D
V
V
V
D
A
I
F
G
T
G
L
R
G
E
I
T
G
E
Y
A
E
I
I
N
L
V
N
K
S
G
K
V
V
V
S
V
D
V
P
S
G
I
D
S
N
T
G
K
V
L
R
T
A
V
K
A
D
L
T
V
T
F
G
V
P
K
I
G
H
I
L
F
----
P
G
R
D
L
T
G
K
L
K
V
A
N
I
G
H
P
V
H
L
I
N
---
S
I
N
R
Y
V
I
T
R
E
M
V
R
S
L
L
P
E
R
P
R
D
S
H
K
G
T
Y
G
K
V
L
I
I
A
G
S
R
L
Y
S
G
A
P
V
L
S
G
M
G
S
L
K
V
G
T
G
L
V
K
L
A
V
P
F
P
Q
--
N
L
I
A
T
S
R
F
P
E
L
I
S
V
P
I
D
-------
T
---------------
E
K
G
FFSLQN
L
Q
E
C
L
E
L
S
K
D
V
D
V
V
A
I
G
P
G
L
G
N
N
E
H
V
R
E
F
V
N
E
F
L
K
T
L
E
K
P
A
V
I
D
A
D
A
I
N
V
L
--
D
T
S
V
L
K
E
R
K
S
P
A
V
L
T
P
H
P
G
E
M
A
R
L
V
K
K
T
V
---
G
D
---
V
K
Y
N
Y
E
L
A
E
E
F
A
K
E
N
D
C
V
L
V
L
K
S
A
T
T
I
V
T
D
-
G
E
K
T
L
F
N
I
T
G
N
T
G
L
S
K
G
G
S
G
D
V
L
T
G
M
I
A
G
F
I
A
Q
G
L
S
P
L
E
A
S
T
V
S
V
Y
L
H
G
F
A
A
E
L
F
E
Q
D
------------------------
40
HHSearch
69.93
30%
-94
- C3 -
3RPZ
3
NNRD_BACSU
A:
[10-278]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
E
E
H
V
R
A
T
L
P
E
R
D
-
A
E
S
H
-
K
G
T
Y
G
T
A
L
L
L
A
G
S
D
D
M
P
G
A
A
L
L
A
G
L
G
A
M
R
S
G
L
G
K
L
V
I
G
T
S
E
N
V
I
P
L
I
V
P
--
V
L
P
E
A
T
Y
W
R
D
G
W
K
K
A
A
D
A
Q
---------------
L
E
E
---------------
T
Y
R
A
I
A
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
H
V
L
T
A
-
D
C
P
V
I
L
D
A
G
A
L
A
K
R
T
Y
--
P
---
K
R
E
G
P
V
I
L
T
P
H
P
G
E
F
F
R
M
T
G
V
P
V
N
E
L
Q
K
---
K
R
A
E
Y
--
A
K
E
W
A
A
Q
L
Q
T
V
I
V
L
K
G
N
Q
T
V
I
A
F
P
D
G
D
C
W
L
N
P
T
G
N
G
A
L
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
D
P
K
H
A
V
L
N
A
V
Y
L
H
G
A
C
A
E
L
W
T
D
E
H
S
--
A
H
T
L
L
A
H
E
L
S
D
I
L
P
R
V
W
K
R
F
25
PsiBlast_CBE
56.94
36%
-98
- C3 -
3RQ6
2
NNRD_BACSU
A:
[104-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
H
V
L
T
A
-
D
C
P
V
I
L
D
A
G
A
L
A
K
R
T
-----
Y
P
K
R
E
G
P
V
I
L
T
P
H
P
G
E
F
F
R
M
T
G
V
P
V
---
N
E
L
Q
K
K
R
A
E
Y
--
A
K
E
W
A
A
Q
L
Q
T
V
I
V
L
K
G
N
Q
T
V
I
A
F
P
D
G
D
C
W
L
N
P
T
G
N
G
A
L
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
D
P
K
H
A
V
L
N
A
V
Y
L
H
----------------------------------
22
PsiBlast_CBE
56.68
36%
-101
- C3 -
3RQQ
2
NNRD_BACSU
A:
[104-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
H
V
L
T
A
-
D
C
P
V
I
L
D
A
G
A
L
A
K
R
T
-----
Y
P
K
R
E
G
P
V
I
L
T
P
H
P
G
E
F
F
R
M
T
G
V
P
V
---
N
E
L
Q
K
K
R
A
E
Y
--
A
K
E
W
A
A
Q
L
Q
T
V
I
V
L
K
G
N
Q
T
V
I
A
F
P
D
G
D
C
W
L
N
P
T
G
N
G
A
L
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
D
P
K
H
A
V
L
N
A
V
Y
L
H
----------------------------------
24
PsiBlast_CBE
56.53
36%
-98
- C3 -
3RQ8
2
NNRD_BACSU
A:
[104-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
H
V
L
T
A
-
D
C
P
V
I
L
D
A
G
A
L
A
K
R
T
-----
Y
P
K
R
E
G
P
V
I
L
T
P
H
P
G
E
F
F
R
M
T
G
V
P
V
---
N
E
L
Q
K
K
R
A
E
Y
--
A
K
E
W
A
A
Q
L
Q
T
V
I
V
L
K
G
N
Q
T
V
I
A
F
P
D
G
D
C
W
L
N
P
T
G
N
G
A
L
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
D
P
K
H
A
V
L
N
A
V
Y
L
H
----------------------------------
27
PsiBlast_CBE
56.09
36%
-100
- C3 -
3RQ2
3
NNRD_BACSU
A:
[104-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
H
V
L
T
A
-
D
C
P
V
I
L
D
A
G
A
L
A
K
R
T
-----
Y
P
K
R
E
G
P
V
I
L
T
P
H
P
G
E
F
F
R
M
T
G
V
P
V
---
N
E
L
Q
K
K
R
A
E
Y
--
A
K
E
W
A
A
Q
L
Q
T
V
I
V
L
K
G
N
Q
T
V
I
A
F
P
D
G
D
C
W
L
N
P
T
G
N
G
A
L
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
D
P
K
H
A
V
L
N
A
V
Y
L
H
----------------------------------
29
PsiBlast_CBE
55.99
36%
-101
- C3 -
3RPH
4
NNRD_BACSU
A:
[104-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
H
V
L
T
A
-
D
C
P
V
I
L
D
A
G
A
L
A
K
R
T
-----
Y
P
K
R
E
G
P
V
I
L
T
P
H
P
G
E
F
F
R
M
T
G
V
P
V
---
N
E
L
Q
K
K
R
A
E
Y
--
A
K
E
W
A
A
Q
L
Q
T
V
I
V
L
K
G
N
Q
T
V
I
A
F
P
D
G
D
C
W
L
N
P
T
G
N
G
A
L
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
D
P
K
H
A
V
L
N
A
V
Y
L
H
----------------------------------
26
PsiBlast_CBE
55.93
36%
-100
- C3 -
3RQ5
1
NNRD_BACSU
A:
[104-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
H
V
L
T
A
-
D
C
P
V
I
L
D
A
G
A
L
A
K
R
T
-----
Y
P
K
R
E
G
P
V
I
L
T
P
H
P
G
E
F
F
R
M
T
G
V
P
V
---
N
E
L
Q
K
K
R
A
E
Y
--
A
K
E
W
A
A
Q
L
Q
T
V
I
V
L
K
G
N
Q
T
V
I
A
F
P
D
G
D
C
W
L
N
P
T
G
N
G
A
L
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
D
P
K
H
A
V
L
N
A
V
Y
L
H
----------------------------------
23
PsiBlast_CBE
55.92
36%
-100
- C3 -
3RQH
2
NNRD_BACSU
A:
[104-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
H
V
L
T
A
-
D
C
P
V
I
L
D
A
G
A
L
A
K
R
T
-----
Y
P
K
R
E
G
P
V
I
L
T
P
H
P
G
E
F
F
R
M
T
G
V
P
V
---
N
E
L
Q
K
K
R
A
E
Y
--
A
K
E
W
A
A
Q
L
Q
T
V
I
V
L
K
G
N
Q
T
V
I
A
F
P
D
G
D
C
W
L
N
P
T
G
N
G
A
L
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
D
P
K
H
A
V
L
N
A
V
Y
L
H
----------------------------------
28
PsiBlast_CBE
55.76
36%
-101
- C3 -
3RPZ
3
NNRD_BACSU
A:
[104-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
H
V
L
T
A
-
D
C
P
V
I
L
D
A
G
A
L
A
K
R
T
-----
Y
P
K
R
E
G
P
V
I
L
T
P
H
P
G
E
F
F
R
M
T
G
V
P
V
---
N
E
L
Q
K
K
R
A
E
Y
--
A
K
E
W
A
A
Q
L
Q
T
V
I
V
L
K
G
N
Q
T
V
I
A
F
P
D
G
D
C
W
L
N
P
T
G
N
G
A
L
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
D
P
K
H
A
V
L
N
A
V
Y
L
H
----------------------------------
21
PsiBlast_CBE
55.45
36%
-101
- C3 -
3RQX
4
NNRD_BACSU
A:
[104-246]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
P
G
L
P
Q
T
E
S
V
Q
Q
A
V
D
H
V
L
T
A
-
D
C
P
V
I
L
D
A
G
A
L
A
K
R
T
-----
Y
P
K
R
E
G
P
V
I
L
T
P
H
P
G
E
F
F
R
M
T
G
V
P
V
---
N
E
L
Q
K
K
R
A
E
Y
--
A
K
E
W
A
A
Q
L
Q
T
V
I
V
L
K
G
N
Q
T
V
I
A
F
P
D
G
D
C
W
L
N
P
T
G
N
G
A
L
A
K
G
G
T
G
D
T
L
T
G
M
I
L
G
M
L
C
C
H
E
D
P
K
H
A
V
L
N
A
V
Y
L
H
----------------------------------