@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3468c: (2016-05-20 )
MGTHAATMRVRAGVRSSPLLLHAGTPPTAAAAESGMRTLVTGSSGHLGEALVRTLRARGADIVSLDSRPSRYTNIVGCVSDRALLRDVMAGVEVVFHAAAHHKPQLAFLPRQAFLDTNIIGTQTVLDAAVAANVRAFVMTSSTTVFGDALTPPADQPAAWIDESVTPIPKNIYGVTKASSEDLCQLAHRNDGLACVVLRVARFFVEGDDMPDLYDGRSQDNIKANEYACRRVALEDAVDAHLNAAQRAPQLGFGRYLVSATTPFTRDDLTQLRTDAASVFARRVPLAAAVWTQRGWRFPDRLDRVYVNSRARRDLNWRPRFDLNAVAARLARGQSVHTPLSQLVGSKAYAHSSYHRGVFAPARP
Atome Classification :
(21 SA)
.........10........20........30........40........50........---------------------60-----.--........--------------70------------------.------------.--...--------....80--------------....-.....90-.........100.......110.-........120.......130-.-----......140.....---..150..-.-----.--------...160.....-------..-.170.......180.......190.......200..-----------------..---------...-----------210--------.--------.-----.---.--------.-----.-----.----------.--220.----.---------.---.---..----..230-...---.....240.......--250---.....---------------------....260-.-.......270.......280--.--.--...---------.----.-290---------..-------......300..----------...---..310.......320........330.......340.......350.......360..-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGTH
A
A
T
M
R
V
RAGVRSS
P
L
L
L
HAGTPP
T
A
A
A
A
ESG
M
R
T
L
V
TGSSG
H
L
G
E
A
L
V
R
T
L
R
ARG---------------------
A
------
D
--
I
V
SLDSRP--------------
S
-------------------
R
------------
Y
--
T
N
I
--------
V
G
CVS---------------
D
R
A
L
-
L
R
D
V
M
A
--
G
V
E
V
V
F
H
A
AAHHKPQ
L
A
FL
P
--
R
-
Q
A
FLDTNIIG
T
Q
T
V
L
D
A
A
V
AA-
N
-----
V
R
A
F
V
M
TSS
T
T
V
FG---DALTPPA-D-----Q--------
P
A
A
W
-IDESVT-------PI-PKNIYGVTKA
S
S
E
D
L
C
Q
L
A
HRND
G
L
A
C
V
V
L
R
V
A
R
F
F
-----------------VE---------GDD-----------MP---------D--------L-----Y---D--------G-----R-----S----------Q--D-NI----K---------
A
---
N
---
E
Y
----
A
C
R
R
--
V
A
L
---
E
D
A
V
D
A
H
L
N
A
A
QRAP--Q-----LGF
G
R
---------------------
Y
L
V
SAT--T-PF
T
R
D
D
L
T
Q
L
R
T
D
A
A
S
V
F
A
R--R--V--P
L
A
---------
A
----
A
-
V
W
----------
T
Q-------RGWR
F
P
D
R
L
D
R
----------
V
Y
V
---
N
S
RARRDLNWRPRF-
D
L
N
A
V
A
A
R
L
ARGQSV
H
T
P
L
S
Q
L
VGSKAYAHSSYHRGVFAPARP-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
83.98
25%
-83
- C1 -
1R6D
2
?
A:
[1-315]
-----------------------------------
M
R
L
L
V
T
G
G
A
G
F
I
G
S
H
F
V
R
Q
L
L
A
G
A
---------------------
Y
PDVPAD
E
--
V
I
V
L
D
S
L
T
YAGNRANLAPVDAD
P
-------------------
R
------------
L
--
R
F
V
--------
H
G
D
I
R
---------------
D
A
G
L
-
L
A
R
E
L
R
--
G
V
D
A
I
V
H
F
A
A
E
S
H
V
D
R
S
I
A
G
--
A
-
S
V
F
T
E
T
N
V
Q
G
T
Q
T
L
L
Q
C
A
V
D
A
-
G
-----
V
G
R
V
V
H
V
S
T
N
Q
V
Y
G
---
S
I
D
---------------------
S
G
S
-
W
T
E
S
S
P
-------
L
E
-
P
N
S
P
Y
A
A
S
K
A
G
S
D
L
V
A
R
A
Y
H
R
T
Y
G
L
D
V
R
I
T
R
C
C
N
N
Y
-----------------
G
P
---------
Y
Q
H
-----------
P
E
---------
K
--------
L
-----
I
---
P
L
F
V
T
----
N
-----
L
L
----
D
----------
G
--
G
-
T
L
PLY-
G
---------
D
---
G
---
A
N
----
V
R
E
W
--
V
H
T
---
D
D
H
C
R
G
I
A
L
V
L
A
G
G
---------
R
A
G
E
I
---------------------
Y
H
I
G
G
G
--
L
-
E
L
T
N
R
E
L
T
G
I
L
L
D
S
L
G
A
D
W
S
--
S
--
V
--
R
K
------------------
V
----------
A
D
----------
R
K
G
H
D
L
R
Y
----------
S
L
D
---
G
G
K
I
E
R
E
L
G
Y
R
P
Q
V
-
S
F
A
D
G
L
A
R
T
V
R
W
Y
R
E
N
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
56
HHSearch
81.21
25%
-80
- C1 -
3KO8
2
?
A:
[1-308]
-----------------------------------
M
R
I
V
V
T
G
G
A
G
F
I
G
S
H
L
V
D
K
L
V
E
L
G
---------------------
Y
------
E
--
V
V
V
V
D
N
L
S
--------------
S
-------------------
G
RREFVNPS----
A
--
E
L
H
--------
V
R
D
L
K
---------------
D
Y
S
W
--
G
A
-
G
I
--
K
G
D
V
V
F
H
F
A
A
N
P
E
V
R
L
S
T
T
E
--
P
-
I
V
H
F
N
E
N
V
V
A
T
F
N
V
L
E
W
A
R
Q
T
-
G
-----
V
R
T
V
V
F
A
S
S
S
T
V
Y
G
---
D
A
D
---------------------
V
I
P
-
T
P
E
E
E
P
-------
Y
K
-
P
I
S
V
Y
G
A
A
K
A
A
G
E
V
M
C
A
T
Y
A
R
L
F
G
V
R
C
L
A
V
R
Y
A
N
V
V
-----------------
G
P
---------
R
L
R
-----------
H
G
---------
V
--------
I
-----
Y
D
F
I
M
--------
K
-----
L
-----
R
R
---------
N
P-
N
-
V
L
E
V
L--------------------
Q
----
R
K
S
Y
--
L
Y
V
---
R
D
A
V
E
A
T
L
A
A
W
K
K
F
E
E
M
D
-----
A
P
F
L
A
---------------------
L
N
V
G
N
V
--
D
-
A
V
R
V
L
D
I
A
Q
I
V
A
E
V
L
G
L
R
P
E
--
I
R
L
V
-----------------------------------------------
G
D
V
K
Y
M
----------
T
L
A
---
V
T
K
L
M
K
L
T
G
W
R
P
T
M
-
T
S
A
E
A
V
K
K
T
A
E
D
L
A
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Fugue
80.86
23%
-70
- C1 -
1Z45
5
GAL10_YEAST
A:
[11-699]
----------------------------------
S
K
I
V
L
V
T
G
G
A
G
Y
I
G
S
H
T
V
V
E
L
I
E
N
G
---------------------
Y
------
D
--
C
V
V
A
D
N
L
S
--------------
N
-------------------
S
------------
T
--
Y
D
S
--------
V
A
R
L
E
V
L
T
K
H
H
I
P
F
Y
EVDLC
D
R
K
G
-
L
E
K
V
F
K
E
Y
K
I
D
S
V
I
H
F
A
G
L
K
A
V
G
E
S
T
Q
I
--
P
-
L
R
Y
Y
H
N
N
I
L
G
T
V
V
L
L
E
L
M
Q
Q
Y
-
N
-----
V
S
K
F
V
F
S
S
S
A
T
V
Y
G
---
D
A
T
R
F
P
N
-
M
-----
I
--------
P
----
I
P
E
E
C
P
-------
L
G
-
P
T
N
P
Y
G
H
T
K
Y
A
I
E
N
I
L
N
D
L
Y
N
S
D
K
-
K
S
W
K
F
A
I
L
R
Y
F
-----------------
N
P
I
G
A
HPSGLI
G
E
D
PLGIPNN
L
L
P
Y
M
A
---------
Q
--------
V
-----
A
---
V
--------
G
-----
R
-----
R
----------
E
--
K
-
L
Y
----
I
---------
F
---
R
---
D
G
----
T
P
I
R
D
Y
I
H
V
---
V
D
L
A
K
G
H
I
A
A
L
Q
Y
L
E
--
A
YNEN
E
G
L
C
R
E
---------------------
W
N
L
G
S
G
--
K
-
G
S
T
---
V
F
E
V
Y
H
A
F
C
K
A
S
G
I
--
D
--
L
--
P
Y
V
---------
L
----
N
-
L
T
----------
A
K
----------------------------------
P
D
R
A
K
R
E
L
K
W
Q
T
E
L
-
Q
V
E
D
S
C
K
D
L
W
K
W
T
T
E
N
--------
P
F
G
Y
Q
L
R
G
V
E
A
R
F
S
A
E
D
M
R
YDA
R
F
V
T
I
GAGTR
F
Q
A
T
F
A
NLGASIV
D
L
K
V
NGQSV
V
L
G
Y
EN
E
E
G
Y
L
NPDSAYIGATIGRYANRISKG
K
F
S
L
CN
K
D
Y
Q
L
TVNNGVNANHSSIGSFHR
K
R
F
L
G
P
I
I
Q
NPSKD
V
F
T
A
E
Y
M
L
I
D
N
EKDTEFP
G
D
L
L
V
T
I
Q
Y
T
V
N
VAQK
S
L
E
I
V
Y
K
G
K
L
TAGE
A
T
P
I
N
L
T
N
H
S
Y
F
N
LNKPYGDTIEG
T
E
I
M
V
RSK
K
S
V
D
V
D
KNMIPTG
N
I
V
D
R
EIATFNSTK
P
T
V
L
G
PKNP
Q
F
D
C
C
F
V
VDENAKPSQINTLNNELTLI
V
K
A
F
H
PDSN
I
T
L
E
V
L
S
TEP
T
Y
Q
F
Y
TGDFLSAGYEARQ
G
F
A
I
E
P
G
RYIDAINQENWKDCVTLKNG
E
T
Y
G
S
K
I
V
Y
R
F
S
59
HHSearch
80.23
22%
-75
- C1 -
1SB8
2
?
A:
[21-350]
----------------------------
K
E
L
P
A
Q
P
K
V
W
L
I
T
G
V
A
G
F
I
G
S
N
L
L
E
T
L
L
K
L
D
---------------------
Q
------
K
--
V
V
G
L
D
N
F
A
--------------
T
GH
Q
R
N
L
D
E
V
R
S
L
V
S
E
K
Q
W
S
N
------------
F
--
K
F
I
--------
Q
G
D
I
R
---------------
N
L
D
D
-
C
N
N
A
C
A
--
G
V
D
Y
V
L
H
Q
A
A
L
G
S
V
P
R
S
I
N
D
--
P
-
I
T
S
N
A
T
N
I
D
G
F
L
N
M
L
I
A
A
R
D
A
-
K
-----
V
Q
S
F
T
Y
A
A
S
S
S
T
Y
G
---
D
H
P
---------------------
G
L
P
-
K
V
E
D
T
I
-------
G
K
-
P
L
S
P
Y
A
V
T
K
Y
V
N
E
L
Y
A
D
V
F
S
R
C
Y
G
F
S
T
I
G
L
R
Y
F
N
V
F
-----------------
G
R
---------
R
Q
D
-----------
P
N
---------
G
--------
A
YAA
V
-
I
---
P
--------
K
-----
W
T
S
S
M
I
Q
----------
G
--
D
-
D
V
----
Y
I
NG------
D
---
G
---
E
T
----
S
R
D
F
--
C
Y
I
---
E
N
T
V
Q
A
N
L
L
A
A
T
A
G
L
--
D
-----
A
R
N
Q
V
---------------------
Y
N
I
A
V
G
--
G
-
R
T
S
L
N
Q
L
F
F
A
L
R
D
G
L
A
E
N
G
V
--
S
--
Y
--
H
R
E
---------
P
------
V
Y
----------
R
---------
D
F
R
E
G
D
V
R
H
S
----------
L
A
D
---
I
S
K
A
A
K
L
L
G
Y
A
P
K
Y
-
D
V
S
A
G
V
A
L
A
M
P
W
Y
I
M
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
80.04
24%
-76
- C1 -
1R6D
2
?
A:
[1-309]
-----------------------------------
M
R
L
L
V
T
G
G
A
G
F
I
G
S
H
F
V
R
Q
L
L
A
G
A
YPDVPAD
E
V
I
V
L
D
SLTYAGNR
A
------
N
--
L
A
P
V
D
A
D
P
----------------------------------
R
------------
L
--
R
F
V
--------
H
G
D
I
R
---------------
D
A
G
L
-
L
A
R
E
L
R
--
G
V
D
A
I
V
H
F
A
A
E
S
H
V
D
R
S
I
A
G
--
A
-
S
V
F
T
E
T
N
V
Q
G
T
Q
T
L
L
Q
C
A
V
D
A
-
G
-----
V
G
R
V
V
H
V
S
T
N
Q
V
Y
G
---
S
I
------------
D
--------
S
G
S
W
-
T
E
S
S
---------
P
L
E
P
N
S
P
Y
A
A
S
K
A
G
S
D
L
V
A
R
A
Y
H
R
T
Y
G
L
D
V
R
I
T
R
C
C
N
N
Y
GPYQHPEK
L
I
P
L
F
V
T
N
L
L
D
---------
G
G
T
-----------
L
P
---------
L
--------
Y
-----
G
---
D
--------
G
-----
A
-----
N
----------
V
--
R
-
E
W
----
V
---------
H
---
T
---
D
D
----
H
C
R
G
--
I
A
L
----------
V
L
A
G
G
R
A
G
--
E
-----
I
-------------------------
Y
H
I
G
G
G
--
L
-
E
L
T
N
R
E
L
T
G
I
L
L
D
S
L
G
A
D
W
S
--
S
--
V
--
R
K
V
---------
A
------------------
D
R
-------
K
G
H
D
L
R
Y
S
L
D
-----------------
G
G
K
I
E
R
E
L
G
Y
R
P
Q
V
-
S
F
A
D
G
L
A
R
T
V
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
HHSearch
79.32
25%
-75
- C1 -
4ID9
3
?
A:
[21-341]
------------------------------------
M
I
L
V
T
G
S
A
G
R
V
G
R
A
V
V
A
A
L
R
T
Q
G
---------------------
R
------
T
--
V
R
G
F
D
L
R
P
--------------
S
-------------------
G
TG----------
G
--
E
E
V
--------
V
G
S
L
E
---------------
D
G
Q
A
-
L
S
D
A
I
M
--
G
V
S
A
V
L
H
L
G
A
F
M
S
W
A
--
P
A
D
--
R
-
D
R
M
F
A
V
N
V
E
G
T
R
R
L
L
D
A
A
S
A
A
-
G
-----
V
R
R
F
V
F
A
S
S
G
E
V
Y
P
---
E
N
R
P
-------------------
E
F
L
P
-
V
T
E
D
H
P
-------
L
C
-
P
N
S
P
Y
G
L
T
K
L
L
G
E
E
L
V
R
F
H
Q
R
S
G
A
M
E
T
V
I
L
R
F
S
H
T
Q
-----------------
D
A
---------
T
E
L
LDEDSFF
S
---
G
P
---------
R
--------
F
F
L
R
P
R
I
H
Q
Q
Q
N
F
GN
A
A
I
A
E
L
----
L
-----
Q
S
R
DI------
G
--
E
-
P
S
----
H
---------
I
---
L
ARN
E
N
GR
P
F
R
M
H
I
--
T
D
T
---
R
D
M
V
A
G
I
L
L
A
L
D
H
P
---
E
-----
A
A
G
G
T
---------------------
F
N
L
G
A
D
--
E
-
P
A
D
F
A
A
L
L
P
K
I
A
A
L
T
G
L
P
I
V
--
T
--
V
--
D
F
-----------------------------
P
-------------
G
D
G
V
Y
Y
----------
H
T
S
---
N
E
R
I
R
N
T
L
G
F
E
A
E
W
-
T
M
D
R
M
L
E
E
A
A
T
A
R
R
Q
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
78.72
24%
-77
- C1 -
1R66
3
?
A:
[1-309]
-----------------------------------
M
R
L
L
V
T
G
G
A
G
F
I
G
S
H
F
V
R
Q
L
L
A
G
A
YPDVPAD
E
V
I
V
L
D
SLTYAGNR
A
------
N
--
L
A
P
V
D
A
D
P
----------------------------------
R
------------
L
--
R
F
V
--------
H
G
D
I
R
---------------
D
A
G
L
-
L
A
R
E
L
R
--
G
V
D
A
I
V
H
F
A
A
E
S
H
V
D
R
S
I
A
G
--
A
-
S
V
F
T
E
T
N
V
Q
G
T
Q
T
L
L
Q
C
A
V
D
A
-
G
-----
V
G
R
V
V
H
V
S
T
D
E
V
Y
G
---
S
I
------------
D
--------
S
G
S
W
-
T
E
S
S
---------
P
L
E
P
N
S
P
Y
A
A
S
K
A
G
S
D
L
V
A
R
A
Y
H
R
T
Y
G
L
D
V
R
I
T
R
C
C
N
N
Y
GPYQHPEK
L
I
P
L
F
V
T
N
L
L
D
---------
G
G
T
-----------
L
P
---------
L
--------
Y
-----
G
---
D
--------
G
-----
A
-----
N
----------
V
--
R
-
E
W
----
V
---------
H
---
T
---
D
D
----
H
C
R
G
--
I
A
L
----------
V
L
A
G
G
R
A
G
--
E
-----
I
-------------------------
Y
H
I
G
G
G
--
L
-
E
L
T
N
R
E
L
T
G
I
L
L
D
S
L
G
A
D
W
S
--
S
--
V
--
R
K
V
---------
A
------------------
D
R
-------
K
G
H
D
L
R
Y
S
L
D
-----------------
G
G
K
I
E
R
E
L
G
Y
R
P
Q
V
-
S
F
A
D
G
L
A
R
T
V
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
78.53
20%
-83
- C1 -
4WOK
3
?
A:
[11-334]
----------------------------------
A
N
N
V
L
V
V
G
G
A
G
F
I
G
S
H
T
A
K
L
L
A
G
Q
G
---------------------
Y
------
A
--
P
V
V
Y
D
N
L
S
--------------
T
-------------------
G
HQSAVRW-----
G
--
D
F
V
--------
E
G
D
I
L
---------------
D
Q
A
R
-
L
V
E
T
M
E
K
Y
A
P
V
A
V
I
H
F
A
A
S
A
Y
V
G
E
S
V
E
D
--
P
-
A
K
Y
Y
R
N
N
V
G
G
T
Q
S
L
L
D
A
C
R
L
T
-
R
-----
T
Q
N
V
I
F
S
S
S
C
A
T
Y
G
---
V
P
S
---------------------
R
L
P
-
I
G
E
G
E
A
-------
Q
N
-
P
I
N
P
Y
G
R
T
K
L
I
A
E
H
M
L
A
D
Y
A
V
A
Y
G
L
R
Y
V
A
L
R
Y
F
N
A
S
-----------------
G
A
---------
D
I
D
-----------
G
E
L
G
E
K
H
DPET
H
--------
L
-----
I
---
P
--------
R
-----
A
M
M
A
A
-
A
----------
G
RL
D
-
V
L
----
E
V
Y
G
DDYETP
D
---
G
---
T
C
----
I
R
D
Y
--
I
H
V
---
T
D
L
A
R
A
H
V
L
A
V
E
H
L
K
E
-
A
-----
G
G
N
L
A
---------------------
V
N
L
G
T
G
--
R
-
G
T
S
I
R
E
I
V
Q
S
I
G
R
L
T
G
R
S
V
P
--
V
-----
A
M
-----------------------------
R
A
---------
R
R
A
G
D
P
P
A
L
----------
Y
A
D
---
P
A
L
A
A
E
K
L
G
F
H
T
V
Y
S
D
L
D
T
I
I
R
T
A
A
P
H
F
G
L
E
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
77.21
23%
-81
- C1 -
3WJ7
2
?
A:
[16-333]
-------------------------------------
T
L
V
T
G
A
T
G
F
V
G
S
A
V
A
R
V
L
E
E
R
G
---------------------
H
------
R
--
L
R
L
L
V
R
P
T
--------------
S
-------------------
D
------------
R
--
S
N
I
AELN
A
E
L
A
V
G
D
L
S
---------------
D
P
D
T
-
L
A
P
A
L
K
--
G
V
K
I
L
F
H
V
A
A
D
Y
R
---
L
W
V
P
--
D
P
E
T
M
M
K
A
N
V
E
G
T
R
N
L
M
L
A
A
L
E
A
-
G
-----
V
E
K
I
I
Y
C
S
S
V
A
A
L
G
L
R
S
D
G
V
--
P
A
-
D
-----
E
--------
T
T
P
V
-
S
E
S
Q
V
I
------------
G
I
Y
K
L
S
K
Y
R
A
E
Q
E
V
L
R
L
I
R
E
K
N
L
P
A
I
I
V
N
P
S
T
P
V
-----------------
G
P
---------
R
D
I
-----------
K
P
---------
T
P
T
G
Q
M
---
I
-----
L
---
D
--------
C
-----
A
-----
S
----------
G
--
N
-
M
P
----
A
---------
Y
---
V
---
E
T
----
G
L
N
I
--
V
H
V
---
D
D
V
A
E
G
H
A
L
A
L
E
R
G
K
----------
I
G
E
---------------------
K
Y
I
L
G
G
--
E
-
N
I
M
L
G
D
L
F
R
M
V
S
Q
I
A
G
V
K
P
P
--
A
--
V
--
K
L
K
QSWL
Y
P
V
A
L
V
----
S
-
E
W
----------
L
A
-------
R
G
F
G
I
E
P
R
V
T
R
E
T
L
A
M
S
K
KLM
F
F
S
---
S
D
K
A
K
K
E
L
G
Y
A
P
R
P
-
A
R
D
A
V
T
D
A
I
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
HHSearch
76.30
17%
-74
- C1 -
1ORR
2
RFBE_SALTI
A:
[2-339]
-----------------------------------
A
K
L
L
I
T
G
G
C
G
F
L
G
S
N
L
A
S
F
A
L
S
Q
G
---------------------
I
------
D
--
L
I
V
F
D
N
L
S
--------------
R
KG
A
T
D
N
L
H
W
L
S
S
L
G
-----
N
------------
F
--
E
F
V
--------
H
G
D
I
R
---------------
N
K
N
D
-
V
T
R
L
I
T
K
Y
M
P
D
S
C
F
H
L
A
G
Q
V
A
M
T
T
S
I
D
N
--
P
-
C
M
D
F
E
I
N
V
G
G
T
L
N
L
L
E
A
V
R
Q
Y
-
N
S----
N
C
N
I
I
Y
S
S
T
N
K
V
Y
G
---
D
L
E
Q
Y
K
Y
N
E
-----
T
ETRYTCVD
K
P
N
G
-
Y
D
E
S
T
Q
-------
L
D
-
F
H
S
P
Y
G
C
S
K
G
A
A
D
Q
Y
M
L
D
Y
A
R
I
F
G
L
N
T
V
V
F
R
H
S
S
M
Y
-----------------
G
G
---------
R
Q
F
-----------
A
T
YDQG-----
W
V
G
------
W
-----
F
C
--
Q
--------
K
-----
A
-----
V
E
I
K
N
------
G
IN
K
-
P
F
T
I
S
-
G
---------
N
---
G
---
K
Q
----
V
R
D
V
--
L
H
A
---
E
D
M
I
S
L
Y
F
T
A
L
A
N
V
S
--
K
-----
I
R
G
N
A
---------------------
F
N
I
G
G
T
IV
N
-
S
L
S
L
L
E
L
F
K
L
L
E
D
Y
C
N
I
D
M
R
--
F
--
T
--
N
---------------------------------------
L
P
V
R
E
S
D
Q
R
V
F
----------
V
A
D
---
I
K
K
I
T
N
A
I
D
W
S
P
K
V
-
S
A
K
D
G
V
Q
K
M
Y
D
W
T
S
S
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
HHSearch
76.24
21%
-74
- C1 -
2PK3
2
RMD_ANETH
A:
[13-319]
-----------------------------------
M
R
A
L
I
T
G
V
A
G
F
V
G
K
Y
L
A
N
H
L
T
E
Q
N
---------------------
V
------
E
--
V
F
G
T
S
R
N
N
--------------
E
A
K
L
P
---------------
N
------------
V
--
E
M
I
--------
S
L
D
I
M
---------------
D
S
Q
R
-
V
K
K
V
I
S
D
I
K
P
D
Y
I
F
H
L
A
A
K
S
S
V
K
D
S
W
L
N
--
K
-
K
G
T
F
S
T
N
V
F
G
T
L
H
V
L
D
A
V
R
D
S
-
N
L----
D
C
R
I
L
T
I
G
S
S
E
E
Y
G
---
M
I
L
P
-------------------
E
E
S
P
-
V
S
E
E
N
Q
-------
L
R
-
P
M
S
P
Y
G
V
S
K
A
S
V
G
M
L
A
R
Q
Y
V
K
A
Y
G
M
D
I
I
H
T
R
T
F
N
H
I
-----------------
G
P
---------
G
Q
S
-----------
L
G
---------
F
--------
V
-----
T
---
Q
--------
D
-----
F
-----
A
K
Q
I
V
D
I
E
M
EK
Q
--
E
-
P
I
----
I
K
V
G
------
N
---
L
---
E
A
----
V
R
D
F
--
T
D
V
---
R
D
I
V
Q
A
Y
W
L
L
S
Q
Y
G
---------
K
T
G
D
V
---------------------
Y
N
V
C
S
G
--
I
-
G
T
R
I
Q
D
V
L
D
L
L
L
A
M
A
N
V
K
I
D
--
T
------
E
L
---------
N
------
P
L
--------------------
Q
L
R
P
S
E
V
P
T
L
----------
I
G
S
---
N
K
R
L
K
D
S
T
G
W
K
P
R
I
-
P
L
E
K
S
L
F
E
I
L
Q
S
Y
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
75.11
23%
-80
- C1 -
2HUN
1
?
A:
[3-315]
----------------------------------
S
M
K
L
L
V
T
G
G
M
G
F
I
G
S
N
F
I
R
Y
I
L
E
K
H
P
D-------------------
W
------
E
--
V
I
N
I
D
K
L
G
YGSNPANLKDLEDD
P
-------------------
R
------------
Y
--
T
F
V
--------
K
G
D
V
A
---------------
D
Y
E
L
-
V
K
E
L
V
R
--
K
V
D
G
V
V
H
L
A
A
E
S
H
V
D
R
S
I
S
S
--
P
-
E
I
F
L
H
S
N
V
I
G
T
Y
T
L
L
E
S
I
R
R
E
N
P
-----
E
V
R
F
V
H
V
S
T
D
E
V
Y
G
---
D
I
L
---------------------
K
G
S
-
F
T
E
N
D
R
-------
L
M
-
P
S
S
P
Y
S
A
T
K
A
A
S
D
M
L
V
L
G
W
T
R
T
Y
N
L
N
A
S
I
T
R
C
T
N
N
Y
-----------------
G
P
---------
Y
Q
F
-----------
P
E
---------
K
--------
L
-----
I
---
P
K
T
I
I
----
R
A
----
S
-----
L
----------
G
--
L
-
K
I
----
P
I
Y
G------
T
-------------
V
R
D
W
--
L
Y
V
---
E
D
H
V
R
A
I
E
L
V
L
L
K
G
---------
E
S
R
E
I
---------------------
Y
N
I
S
A
G
--
E
-
E
K
T
N
L
E
V
V
K
I
I
L
R
L
M
G
K
G
E
E
--
L
--
I
--
E
L
V
---------
E
-------------------
D
----------
R
P
G
H
D
L
R
Y
----------
S
L
D
---
S
W
K
I
T
R
D
L
K
W
R
P
K
Y
-
T
F
D
E
G
I
K
K
T
I
D
W
Y
L
K
N
E
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
Fugue
74.73
26%
-68
- C1 -
4ID9
3
?
A:
[21-341]
M
------------------------------------
I
L
V
T
G
S
A
G
R
V
G
R
A
V
V
A
A
L
R
T
Q
G
---------------------
R
------
T
--
V
R
G
F
D
L
R
P
--------------
S
GT-----------------
G
------------
G
--
E
E
V
--------
V
G
S
L
E
---------------
D
G
Q
A
-
L
S
D
A
I
M
--
G
V
S
A
V
L
H
L
G
A
F
--
M
S
W
A
P
A
D
--
R
-
D
R
M
F
A
V
N
V
E
G
T
R
R
L
L
D
A
A
S
A
A
-
G
-----
V
R
R
F
V
F
A
S
S
G
E
V
Y
P
---
E
--
N
R
P
E
-
F
-----
L
--------
P
----
V
T
E
D
H
P
-------
L
C
-
P
N
S
P
Y
G
L
T
K
L
L
G
E
E
L
V
R
F
H
Q
R
S
G
A
M
E
T
V
I
L
R
F
S
H
T
Q
-----------------
D
A
---------
T
E
L
-----------
L
D
---------
E
--------
D
-----
S
---
F
--------
F
-----
S
-----
G
----------
P
--
R
-
F
F
----
L
---------
R
---
P
---
R
I
----
H
Q
Q
Q
--
N
F
G
---
N
A
A
I
A
E
L
L
Q
S
R
D
I
G
E
--
P
-----
S
H
I
L
A
RNENGR
P
F
R
M
H
I
T
D
T
R
D
M
V
A
G
I
L
L
A
L
D
--
H
-
P
E
A
A
G
G
T
F
N
L
G
A
D
E
P
A
D
F
A
A
--
L
--
L
--
P
K
I
---------
A
----
A
-
L
T
----------
G
L
-------
P
I
V
T
V
D
F
P
G
D
G
----------
V
Y
Y
H
T
S
N
E
R
I
R
N
T
L
G
F
E
A
E
W
-
T
M
D
R
M
L
E
E
A
A
T
A
R
R
Q
R
L
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
51
HHSearch
72.19
19%
-76
- C1 -
1OC2
4
?
A:
[3-330]
---------------------------------
Q
F
K
N
I
I
V
T
G
G
A
G
F
I
G
S
N
F
V
H
Y
V
Y
N
N
H
---------------------
P
------
D
V
H
V
T
V
L
D
K
L
T
YAGNKANLEAILG-
D
-------------------
R
------------
V
--
E
L
V
--------
V
G
D
I
A
---------------
D
A
E
L
-
V
D
K
L
A
A
--
K
A
D
A
I
V
H
Y
A
A
E
S
H
N
D
N
S
L
N
D
--
P
-
S
P
F
I
H
T
N
F
I
G
T
Y
T
L
L
E
A
A
R
K
Y
-
D
-----
I
-
R
F
H
H
V
S
T
D
E
V
Y
G
---
D
L
P
L
R
E
D
-
L
PGHGE
G
--------
P
G
E
K
-
F
T
A
E
T
N
-------
Y
N
-
P
S
S
P
Y
S
S
T
K
A
A
S
D
L
I
V
K
A
W
V
R
S
F
G
V
K
A
T
I
S
N
C
S
N
N
Y
-----------------
G
P
---------
Y
Q
H
-----------
I
E
---------
K
--------
F
-----
I
---
P
--------
R
Q
I
T
N
I
L
-----
A
----------
G
--
I
-
K
P
----
K
L
Y
G------
E
---
G
---
K
N
----
V
R
D
W
--
I
H
T
---
N
D
H
S
T
G
V
W
A
I
L
T
K
G
---------
R
M
G
E
T
---------------------
Y
L
I
G
A
D
--
G
-
E
K
N
N
K
E
V
L
E
L
I
L
E
K
M
G
Q
P
K
D
--
A
--
Y
--
D
H
------------------
V
----------
T
----------
D
R
A
G
H
D
L
R
Y
----------
A
I
D
---
A
S
K
L
R
D
E
L
G
W
T
P
Q
F
T
D
F
S
E
G
L
E
E
T
I
Q
W
Y
T
D
N
Q
D
W
W
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
Fugue
71.44
21%
-80
- C1 -
3RFT
4
URODH_AGRFC
A:
[1-266]
--------------------------------
M
A
M
K
R
L
L
V
T
G
A
A
G
Q
L
G
R
V
M
R
E
R
L
A
P
M
A
---------------------
E
------
I
--
L
R
L
A
D
L
S
P
LDPAG---------
P
-------------------
N
------------
E
--
E
C
V
--------
Q
C
D
L
A
---------------
D
A
N
A
-
V
N
A
M
V
A
--
G
C
D
G
I
V
H
L
G
G
I
S
V
E
K
----
P
--
F
-
E
Q
I
L
Q
G
N
I
I
G
L
Y
N
L
Y
E
A
A
R
A
H
-
G
-----
Q
P
R
I
V
F
A
S
S
N
H
T
I
G
---
Y
Y
P
Q
T
E
R
---------------------
L
G
P
D
V
P
-------
A
R
-
P
D
G
L
Y
G
V
S
K
C
F
G
E
N
L
A
R
M
Y
F
D
K
F
G
Q
E
T
A
L
V
R
I
G
S
C
T
-----------------
P
E
---------
P
N
N
-----------
Y
--------------------------------------------------------------------------------------------------
R
M
--
L
S
T
WFS
H
D
D
F
V
S
L
I
E
A
V
F
R
A
P
--
V
-----
L
G
C
P
V
---------------------
V
W
G
A
S
A
--
N
------------------------------------------------------------------------------
D
A
----------
G
W
W
---
D
N
S
H
L
G
F
L
G
W
K
P
K
D
-
N
A
E
A
F
R
R
H
I
T
E
T
T
P
P
P
D
P
N
D
--------
A
L
V
R
F
Q
G
G
T
F
V
D
N
P
I
FKQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
47
HHSearch
70.31
16%
-68
- C1 -
1N7H
2
GMD2_ARATH
A:
[28-366]
----------------------------------
R
K
I
A
L
I
T
G
I
T
G
Q
D
G
S
Y
L
T
E
F
L
L
G
K
G
---------------------
Y
------
E
--
V
H
G
L
I
R
R
S
--------------
S
-------------------
N
FNTQRINHIYAL
M
--
K
L
H
--------
Y
A
D
L
T
---------------
D
A
S
S
-
L
R
R
W
I
D
V
I
K
P
D
E
V
Y
N
L
A
A
Q
S
H
V
A
V
S
F
E
I
--
P
-
D
Y
T
A
D
V
V
A
T
G
A
L
R
L
L
E
A
V
R
S
H
-
T
I
D
S
G
R
T
V
K
Y
Y
Q
A
G
S
S
E
M
F
G
---
S
T
P
----------------------
P
P
-
Q
S
E
T
T
P
-------
F
H
-
P
R
S
P
Y
A
A
S
K
C
A
A
H
W
Y
T
V
N
Y
R
E
A
Y
G
L
F
A
C
N
G
I
L
F
N
H
E
-----------------
S
P
---------
R
R
G
-----------
E
N
---------
F
--------
V
-----
T
---
R
--------
K
-----
I
-----
T
R
A
L
G
R
I
K
V
--
G
--
L
-
Q
T
K
L
F
L
G
---------
N
---
L
---
Q
A
----
S
R
D
W
--
G
F
A
---
G
D
Y
V
E
A
M
W
L
M
L
Q
Q
E
----------
K
P
D
D
---------------------
Y
V
V
A
T
E
--
E
-
G
H
T
V
E
E
F
L
D
V
S
F
G
Y
L
G
L
N
W
K
--
D
--
Y
--
V
E
I
---------
D
-------------------
Q
-------
R
Y
F
R
P
A
E
V
D
N
L
----------
Q
G
D
---
A
S
K
A
K
E
V
L
G
W
K
P
Q
V
-
G
F
E
K
L
V
K
M
M
V
D
E
D
L
E
L
A
K
R
E
K
V
L
V
D
A
G
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
69.21
16%
-83
- C1 -
2BLL
-
ARNA_ECOLI
A:
[316-654]
-----------------------------------
M
R
V
L
I
L
G
V
N
G
F
I
G
N
H
L
T
E
R
L
L
R
E
D
H--------------------
Y
------
E
--
V
Y
G
L
D
I
G
S
--------------
D
AISRFLNHP----------
H
------------
F
--
H
F
V
--------
E
G
D
I
S
---------------
I
H
S
E
W
I
E
Y
H
V
K
--
K
C
D
V
V
L
P
L
V
A
I
A
T
P
I
E
Y
T
R
N
--
P
-
L
R
V
F
E
L
D
F
E
E
N
L
R
I
I
R
Y
C
V
K
Y
-------
R
K
R
I
I
F
P
S
T
S
E
V
Y
G
---
M
C
S
---------------------
D
K
Y
-
F
D
E
D
H
S
N
L
I
V
G
P
V
N
K
-
P
R
W
I
Y
S
V
S
K
Q
L
L
D
R
V
I
W
A
Y
G
E
K
E
G
L
Q
F
T
L
F
R
P
F
N
W
M
-----------------
G
P
---------
R
L
D
-----------
N
L
---------
N
AARIGSS
R
A
-----
I
---
T
--------
Q
L
I
L
N
-
L
V
----
E
----------
G
--
S
-
P
I
K
LI-
D
---------
G
---
G
---
K
Q
----
K
R
C
F
--
T
D
I
---
R
D
G
I
E
A
L
Y
R
I
I
E
N
A
G
N-
R
-----
C
D
G
E
I
---------------------
I
N
I
G
N
P
--
E
N
E
A
S
I
E
E
L
G
E
M
L
L
A
S
F
E
K
H
P
L
RH
H
--
F
--
P
P
F
---------
A
----
G
F
R
V
----------
V
---------------
V
E
H
R
----------
K
P
S
---
I
R
N
A
H
R
C
L
D
W
E
P
K
I
-
D
M
Q
E
T
I
D
E
T
L
D
F
F
L
R
T
V
D
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
57
HHSearch
68.90
14%
-78
- C1 -
1DB3
-
GM4D_ECOLI
A:
[1-357]
----------------------------------
S
K
V
A
L
I
T
G
V
T
G
Q
D
G
S
Y
L
A
E
F
L
L
E
K
G
---------------------
Y
------
E
--
V
H
G
I
K
R
-----------------P------------------
K
------------
F
--
H
L
H
--------
Y
G
D
L
S
---------------
D
T
S
N
-
L
T
R
I
L
R
E
V
Q
P
D
E
V
Y
N
L
G
A
M
S
H
V
A
V
S
F
E
S
--
P
-
E
Y
T
A
D
V
D
A
M
G
T
L
R
L
L
E
A
I
R
F
L
-
G
LEK--
K
T
R
F
Y
Q
A
S
T
S
E
L
Y
G
---
L
V
Q
---------------------
E
I
P
-
Q
K
E
T
T
P
-------
F
Y
-
P
R
S
P
Y
A
V
A
K
L
Y
A
Y
W
I
T
V
N
Y
R
E
S
Y
G
M
Y
A
C
N
G
I
L
F
N
H
E
-----------------
S
P
---------
R
R
G
-----------
E
T
---------
F
--------
V
T
R
K
--
I
---
T
--------
R
A
----
I
A
N
I
--
A
Q
---------
G
--
L
E
S
C
L
Y
L
-
G
---------
N
---
M
---
D
S
----
L
R
D
W
--
G
H
A
---
K
D
Y
V
K
M
Q
W
M
M
L
Q
Q
E
----------
Q
P
E
D
---------------------
F
V
I
A
T
G
--
V
-
Q
Y
S
V
R
Q
F
V
E
M
A
A
A
Q
L
G
I
K
L
R
--
F
--
E
G
T
G
V
E
---------
E
K
G
I
V
V
-
S
V
TGHDAPGVKP
G
D
VI
I
A
V
D
P
R
Y
F
R
P
A
E
-
E
T
L
----------
L
G
D
---
P
T
K
A
H
E
K
L
G
W
K
P
E
I
-
T
L
R
E
M
V
S
E
M
V
A
N
D
L
E
A
A
K
K
H
S
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
39
HHSearch
68.18
17%
-74
- C1 -
4EGB
19
?
A:
[24-341]
----------------------------------
A
M
N
I
L
V
T
G
G
A
G
F
I
G
S
N
F
V
H
Y
M
L
Q
S
Y
ET-------------------
Y
------
K
--
I
I
N
F
D
A
L
T
YSGNLNNVKSIQDH
P
-------------------
N
------------
Y
--
Y
F
V
--------
K
G
E
I
Q
---------------
N
G
E
L
-
L
E
H
V
I
K
E
R
D
V
Q
V
I
V
N
F
A
A
E
S
------------
I
P
F
Y
D
T
N
V
I
G
T
V
T
L
L
E
L
V
K
K
Y
-
P
-----
H
I
K
L
V
Q
V
S
T
D
E
V
Y
G
---
S
L
G
K
--------------------
T
G
R
-
F
T
E
E
T
P
-------
L
A
-
P
N
S
P
Y
S
S
S
K
A
S
A
D
M
I
A
L
A
Y
Y
K
T
Y
Q
L
P
V
I
V
T
R
C
S
N
N
Y
-----------------
G
P
---------
Y
Q
Y
-----------
P
E
---------
K
--------
L
-----
I
---
P
--------
L
-----
M
V
T
N
A
L
E
----------
G
--
K
-
K
L
----
P
---------
L
Y
G
D
G
---
L
N
----
V
R
D
W
--
L
H
V
---
T
D
H
C
S
A
I
D
V
V
L
H
K
G
---------
R
V
G
E
V
---------------------
Y
N
I
G
G
N
--
N
-
E
K
T
N
V
E
V
V
E
Q
I
I
T
L
L
G
K
T
K
K
--
D
--
I
--
E
Y
------------------
V
----------
T
D
------------
G
H
D
R
R
Y
----------
A
I
N
---
A
E
K
M
K
N
E
F
D
W
E
P
K
Y
-
T
F
E
Q
G
L
Q
E
T
V
Q
W
Y
E
K
N
E
E
W
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
67.82
34%
-101
- C1 -
4IDG
4
?
B:
[23-190]
--------------------------------------
L
V
T
G
S
A
G
R
V
G
R
A
V
V
A
A
L
R
T
Q
G
---------------------
R
------
T
--
V
R
G
F
D
L
R
P
--------------
S
-------------------
G
------------
T
GG
E
E
V
--------
V
G
S
L
E
---------------
D
G
Q
A
-
L
S
D
A
I
M
--
G
V
S
A
V
L
H
L
G
A
F
----
M
S
W
A
P
AD
R
-
D
R
M
F
A
V
N
V
E
G
T
R
R
L
L
D
A
A
S
A
A
-
G
-----
V
R
R
F
V
F
A
S
S
G
E
V
Y
---------
P
E
-
N
-----
R
--------
P
E
F
L
P
V
T
E
D
H
P
-------
L
C
-
P
N
S
P
Y
G
L
T
K
L
L
G
E
E
L
V
R
F
H
Q
R
S
G
A
M
E
T
V
I
L
R
----
F
-----------------
S
H
---------
T
Q
D
-----------
A
T
---------
E
--------
L
-----
L
---
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
66.42
34%
-102
- C1 -
4ID9
1
?
B:
[23-190]
--------------------------------------
L
V
T
G
S
A
G
R
V
G
R
A
V
V
A
A
L
R
T
Q
G
---------------------
R
------
T
--
V
R
G
F
D
L
R
P
--------------
S
-------------------
G
------------
T
GG
E
E
V
--------
V
G
S
L
E
---------------
D
G
Q
A
-
L
S
D
A
I
M
--
G
V
S
A
V
L
H
L
G
A
F
----
M
S
W
A
P
AD
R
-
D
R
M
F
A
V
N
V
E
G
T
R
R
L
L
D
A
A
S
A
A
-
G
-----
V
R
R
F
V
F
A
S
S
G
E
V
Y
---------
P
E
-
N
-----
R
--------
P
E
F
L
P
V
T
E
D
H
P
-------
L
C
-
P
N
S
P
Y
G
L
T
K
L
L
G
E
E
L
V
R
F
H
Q
R
S
G
A
M
E
T
V
I
L
R
----
F
-----------------
S
H
---------
T
Q
D
-----------
A
T
---------
E
--------
L
-----
L
---
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------