@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3515c: (2016-05-20 )
MAVALNIADLAEHAIDAVPDRVAVICGDEQLTYAQLEDKANRLAHHLIDQGVQKDDKVGLYCRNRIEIVIAMLGIVKAGAILVNVNFRYVEGELRYLFDNSDMVALVHERRYADRVANVLPDTPHVRTILVVEDGSDQDYRRYGGVEFYSAIAAGSPERDFGERSADAIYLLYTGGTTGFPKGVMWRHEDIYRVLFGGTDFATGEFVKDEYDLAKAAAANPPMIRYPIPPMIHGATQSATWMALFSGQTTVLAPEFNADEVWRTIHKHKVNLLFFTGDAMARPLVDALVKGNDYDLSSLFLLASTAALFSPSIKEKLLELLPNRVITDSIGSSETGFGGTSVVAAGQAHGGGPRVRIDHRTVVLDDDGNEVKPGSGMRGVIAKKGNIPVGYYKDEKKTAETFRTINGVRYAIPGDYAQVEEDGTVTMLGRGSVSINSGGEKVYPEEVEAALKGHPDVFDALVVGVPDPRYGQQVAAVVQARPGCRPSLAELDSFVRSEIAGYKVPRSLWFVDEVKRSPAGKPDYRWAKEQTEARPADDVHAGHVTSGG
Atome Classification :
(20 SA)
------------------------------------------------------------------.........10-....-----....20.....------.------.-----.30........40.......-.50........60........70........80........90........100......---------.110.-----...-...-120--.----.---------.--......130..-....-.140.....--...150--..-...------.-.--.---.160.....-..---.170.......180.......190----.--........200.-----......-210.......220...-...-.-230.....--.--.-240.......250---..--.----.-...260.......270.......280..----.----....290...-.....300.....---..310.......320--..--.---....330....-...340----......--.---.---.350---.--....-.-.-.-----------------.360....-...370---...-......380.----.----.....-390.......400..---.----....410.......420.......430.......440.......450.......460.......470-........480..-----...---..---490......-.500.-......510.......520.......530...-....540......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------------------------------
M
A
V
A
L
N
I
A
D
L
A
-
E
H
A
I
-----
D
AVP
D
R
V
A
V
I
C------G------D-----EQL
T
Y
A
Q
L
E
D
K
A
N
R
L
A
H
H
L
I
-
D
QGVQKDDKV
G
L
Y
C
R
N
R
I
E
I
V
I
A
M
L
G
I
VKA
G
A
I
L
V
N
V
N
F
R
Y
VE
G
E
L
R
Y
L
FDNS
D
M
V
A
L
V
H
---------
E
R
R
Y
A
-----
D
R
V
-
A
N
V-L----P----D---------T--PH
V
R
T
I
L
V
V
ED-GS
D
Q
-
D
Y
-
R
R
YG
G
V
--
E
F
Y
S
----
A
I
-AAG------S-P--E---RD-FGERSA-
D
A
---
I
Y
L
L
Y
TGGTTGFPKGVM
W
R
H
E
D
------
I
--
Y
R
V
L
FGGTDFAT-----GEF
V
K
D
-
E
Y
D
L
A
K
AAAANP
P
M
I
R-YPI-P-PMIHGATQ--S--
A
-
T
W
M
A
L
FSG
Q
T
T
V
L
---AP--E----F-
N
A
D
E
V
W
R
T
I
H
KHK
V
N
L
L
F
FTG
D
A
M
A
R
P
L
----
V
----
D
A
L
VK-GNDY-
D
L
S
S
L
F
L
L
A
S
T
A
A
---LFS
P
S
I
K
E
K
L
L
E
LLP--N
R
--
V
---ITDSIGSSETG-FGGT------
S
V
V
A
AG--Q---A---HG-----G--G
P
R
V
-
R
-
I
-
D
-----------------
H
R
T
V
V
LDD-DGNE-----VKP-GSGMR
G
V
I
AK----K----GNIPV-
G
Y
YKD
E
K
K
T
A
E
T
F
R
T---I----N
G
V
R
Y
AIPGDY
A
Q
VEEDG
T
V
T
M
L
GR
G
S
V
S
INSGGEKV
Y
P
E
E
V
E
A
A
LKGH
P
D
V
F
D
A
L
VVGVPDPR
Y
G
--
Q
Q
V
A
A
V
V
QARPGC-----R
P
S
---
L
A
---
E
L
D
S
F
V
R
S
E
-IAGYK-V
P
R
S
L
W
F
V
D
E
V
KRSPAGKPDYRW
A
K
E
QTEARP-ADDVHAGHVTSGG
44
HHSearch
91.22
23%
-82
* C5 *
2D1S
3
LUCI_LUCCR
A:
[22-544]
---------------------------------------------------------------------
E
G
S
A
G
T
Q
L
-
R
K
Y
M
-----
E
R
Y
A
K
L
G
A
I
A
F
TNAV--
T
------
G
-----
V
D
Y
S
Y
A
E
Y
L
E
K
S
C
C
L
G
K
A
L
Q
-
N
Y
G
L
V
V
D
G
R
I
A
L
C
S
E
N
C
E
E
F
F
I
P
V
I
A
G
L
F
I
G
V
G
V
A
P
T
N
E
I
Y
T
L
R
E
L
V
H
S
L
G
I
S
K
P
T
I
V
F
S
---------
S
K
K
G
L
-----
D
K
V
-
I
T
V
-
Q
----
K
----
T
---------
V
--
T
T
I
K
T
I
V
I
L
D
S
-
K
V
D
---
Y
---
R
G
Y
Q
--
C
L
D
T
----
F
I
-
K
R
N
TPPGFQ
A
S
S
--
F
---
K
T
V
E
V
D
R
K
E
-
Q
V
---
A
L
I
M
N
S
S
G
S
T
G
L
P
K
G
V
Q
L
T
H
E
N
------
I
--
V
T
R
F
S
H
A
R
--------------
D
-
P
I
Y
---
G
N
Q
V
S
P
G
T
A
V
-
L
T
V
-
V
-
P
F
H
H
G
F
G
M
--
F
--
T
-
T
L
G
Y
L
I
C
G
F
R
V
V
M
---
L
T
--
K
----
F
-
D
E
E
T
F
L
K
T
L
Q
D
Y
K
C
T
S
V
I
L
V
P
T
L
F
A
-
I
L
----
N
----
K
S
E
L
--
L
N
K
Y
-
D
L
S
N
L
V
E
I
A
S
G
G
A
---
P
L
S
K
E
V
G
E
A
V
A
R
R
F
N
--
L
P
--
G
---
V
R
Q
G
Y
G
L
T
E
T
T
-
S
A
I
I
------
I
T
P
E
-
G
--
D
---
D
---
K
P
-----
G
--
A
S
G
K
-
V
V
P
-
L
-----------------
F
K
A
K
V
I
D
L
D
T
K
K
S
-----
L
G
P
-
N
R
R
G
E
V
C
V
K
G
----
P
-----
M
L
M
K
-
G
Y
V
N
N
P
E
A
T
K
E
L
I
D
----------
E
E
G
W
L
H
T
G
D
I
G
Y
Y
D
E
E
K
H
F
F
I
V
D
R
L
K
S
L
I
K
Y
K
G
Y
Q
V
P
P
A
E
L
E
S
V
L
L
Q
H
P
S
I
F
D
A
G
V
A
G
V
P
D
P
V
A
G
--
E
L
P
G
A
V
V
V
L
E
S
G
K
-----
N
M
T
---
E
K
---
E
V
M
D
Y
V
A
S
Q
-
V
S
N
A
K
R
L
R
G
G
V
R
F
V
D
E
V
P
K
G
L
T
G
K
I
D
G
R
A
I
R
E
I
L
K
K
P
---------------
60
HHSearch
90.69
25%
-88
- C5 -
1MDB
4
DHBE_BACSU
A:
[25-534]
----------------------------------------------------------------------
E
T
F
G
D
L
L
-
R
D
R
A
-----
A
K
Y
G
D
R
I
A
I
T
C
------
G
------
N
-----
T
H
W
S
Y
R
E
L
D
T
R
A
D
R
L
A
A
G
F
Q
-
K
L
G
I
Q
Q
K
D
R
V
V
V
Q
L
P
N
I
K
E
F
F
E
V
I
F
A
L
F
R
L
G
A
L
P
V
F
A
L
P
S
H
R
S
S
E
I
T
Y
F
C
E
F
A
E
A
A
A
Y
I
I
---------
P
D
A
Y
S
-----
G
F
D
Y
R
S
L
-
A
R
Q
V
Q
S
----
K
---------
L
--
P
T
L
K
N
I
I
V
A
G
E
-
A
E
E
---------
F
L
--
P
L
E
D
----
L
--
H
T
-------
E
-
P
--
V
---
K
L
-
P
E
V
K
S
S
-
D
V
---
A
F
L
Q
L
S
G
G
S
T
G
L
S
K
L
I
P
R
T
H
D
D
------
Y
--
I
Y
S
L
K
R
S
V
--------------
E
-
V
C
W
------
L
D
H
S
T
V
Y
-
L
A
A
-
L
-
P
M
A
H
N
Y
P
L
SS
P
--
G
-
V
L
G
V
L
Y
A
G
G
R
V
V
L
---
S
P
--
S
----
P
-
S
P
D
D
A
F
P
L
I
E
R
E
K
V
T
I
T
A
L
V
P
P
L
A
M
V
-
W
----
M
----
D
A
A
S
--
S
R
R
D
-
D
L
S
S
L
Q
V
L
Q
V
G
G
A
---
K
F
S
A
E
A
A
R
R
V
K
A
V
F
---
G
C
--
T
---
L
Q
Q
V
F
G
M
A
E
G
L
-
V
N
Y
T
------
R
L
D
D
P
E
--
E
---
I
I
V
N
T
Q
-----
G
--
K
P
-
M
-
S
-
P
-
Y
-----------------
D
E
S
R
V
W
D
D
-
H
D
R
D
-----
V
K
P
-
G
E
T
G
H
L
L
T
R
G
---------
P
Y
T
I
R
-
G
Y
Y
K
A
E
E
H
N
A
A
S
F
T
----------
E
D
G
F
Y
R
T
G
D
I
V
R
L
T
R
D
G
Y
I
V
V
E
G
R
A
K
D
Q
I
N
R
G
G
E
K
V
A
A
E
E
V
E
N
H
L
L
A
H
P
A
V
H
D
A
A
M
V
S
M
P
D
Q
F
L
G
--
E
R
S
C
V
F
I
I
P
R
D
E
A
------
P
K
---
A
A
---
E
L
K
A
F
L
R
E
R
G
L
A
A
Y
K
-
I
P
D
R
V
E
F
V
E
S
F
P
Q
T
G
V
G
K
V
S
K
K
A
L
R
E
A
I
S
E
K
L
-
L
------------
51
HHSearch
87.93
23%
-85
- C5 -
4WV3
1
?
A:
[9-522]
---------------------------------------------------------------------
Y
Y
N
A
V
D
I
L
-
E
R
N
L
-----
P
V
R
A
N
K
T
A
L
F
T
------
P
------
D
-----
R
E
M
T
F
R
Q
V
S
N
E
A
N
Q
V
G
N
A
L
K
-
G
L
G
V
R
F
G
E
C
V
G
L
L
T
L
D
S
A
E
W
V
T
S
F
F
G
I
V
K
L
G
A
I
A
V
G
I
N
T
L
L
K
P
P
E
Y
E
Y
I
L
R
D
C
R
A
R
V
L
I
V
---------
H
Q
E
F
L
-----
P
L
I
-
E
S
I
-
R
----
G
----
N
---------
L
--
P
M
L
E
H
I
V
V
I
G
-------------
G
Y
L
--
S
F
N
D
----
W
I
-
R
P
Q
------
P
T
T
--
L
---
E
A
-
A
Q
S
H
R
E
-
D
I
---
C
S
L
N
Y
S
S
G
-
T
G
G
P
K
G
I
P
H
A
H
K
D
------
Y
--
P
L
T
A
Q
L
W
-------------
G
V
N
-
V
L
G
------
L
R
E
S
D
R
T
-
F
A
L
-
A
-
K
L
F
F
T
F
G
T
--
G
G
-
N
-
L
I
F
P
W
Y
V
G
A
S
C
V
L
---
F
P
--
G
AA--
R
-
V
A
S
N
V
L
S
T
I
S
R
F
K
P
T
I
F
Y
N
A
P
T
G
Y
A
A
-
A
----
L
----
A
L
-
K
D
-
F
S
Q
H
-
D
L
S
S
L
R
L
C
V
S
A
S
E
---
A
L
P
A
A
L
W
Y
A
W
K
E
A
T
---
G
V
--
D
---
I
I
D
G
I
G
C
T
E
N
F
-
H
I
F
I
------
S
N
R
P
-
G
--
D
---
I
---
R
P
-----
G
--
S
S
G
K
-
P
V
E
-
G
-----------------
Y
E
L
K
L
V
D
D
-
E
G
K
T
-----
V
P
A
-
G
E
I
G
N
V
L
L
R
S
----
E
-----
T
A
A
L
-
S
Y
W
H
N
F
E
K
S
R
Q
T
F
-----------
Q
G
E
W
L
A
T
G
D
K
Y
F
V
D
A
D
G
Y
Y
W
H
A
G
R
S
D
D
M
L
K
V
G
G
I
W
V
S
P
V
E
V
E
S
T
L
I
Q
H
P
A
V
Q
E
C
A
V
I
G
C
P
D
Q
S
R
L
--
I
K
P
K
A
F
I
I
L
K
P
E
Q
I
P
S
--
E
A
L
---
I
R
---
Q
I
T
D
H
C
T
E
K
-
M
A
A
Y
K
-
R
P
R
W
I
E
F
V
T
E
L
P
K
T
A
T
G
K
I
Q
R
F
K
L
R
S
A
A
K
L
A
A
-
A
L
-----------
4
PsiBlast_PDB
87.05
26%
-89
- C5 -
1MDB
4
DHBE_BACSU
A:
[40-519]
-------------------------------------------------------------------------------------------
D
R
I
A
I
T
C
------
G
------
N
-----
T
H
W
S
Y
R
E
L
D
T
R
A
D
R
L
A
A
G
F
Q
-
K
L
G
I
Q
Q
K
D
R
V
V
V
Q
L
P
N
I
K
E
F
F
E
V
I
F
A
L
F
R
L
G
A
L
P
V
F
A
L
P
S
H
R
S
S
E
I
T
Y
F
C
E
F
A
E
A
A
A
Y
I
I
---------
P
D
A
Y
S
GFD
Y
R
S
L
A
-
R
Q
V
-
Q
----
S
----
K
---------
L
--
P
T
L
K
N
I
I
V
A
G
E
-
A
E
E
-------
F
L
P
L
--
E
D
L
H
----
T
E
-
P
V
K
------
L
-
P
--
E
--------
V
K
S
S
-
D
V
---
A
F
L
Q
L
S
G
G
S
T
G
L
S
K
L
I
P
R
T
H
D
D
------
Y
--
I
Y
S
L
K
R
S
V
E
V
C
W
-------------
L
D
H
S
T
V
Y
L
A
A
L
P
M
A
H
N
Y
P
L
S
S
-
P
G
V
L
G
-------------
V
L
Y
A
G
G
R
V
V
L
---
S
P
--
S
----
P
-
S
P
D
D
A
F
P
L
I
E
R
E
K
V
T
I
-----
T
A
L
V
P
P
L
A
M
V
W
M
----
D
A
A
S
S
-
R
R
D
--
D
L
S
S
L
Q
V
L
Q
V
G
G
A
---
K
F
S
A
E
A
A
R
R
V
-----------------------
K
A
V
-
F
G
C
T
------
L
Q
Q
V
F
G
--
M
---
A
---
E
G
-----
L
--
V
N
Y
T
-
R
-
L
-
D
DP
E
E
I
I
V
NTQGKPMSPY
D
E
S
R
V
W
D
D
-
H
D
R
D
-----
V
K
P
-
G
E
--
T
G
H
L
L
T
----
R
----
G
P
Y
T
I
R
G
Y
Y
K
A
E
E
H
N
A
A
S
F
-
T
---
E
----
D
G
--
F
Y
R
T
G
D
I
V
R
L
T
R
D
G
Y
I
V
V
E
G
R
A
K
D
Q
I
N
R
G
G
E
K
V
A
A
E
E
V
E
N
H
L
L
A
H
P
A
V
H
D
A
A
M
V
S
M
P
D
Q
F
L
G
--
E
R
S
C
V
F
I
I
P
R
D
E
A
------
P
K
---
A
A
---
E
L
K
A
F
L
R
E
R
G
L
A
A
Y
K
-
I
P
D
R
V
E
F
V
E
S
F
P
Q
T
G
V
G
K
----------------------------
5
PsiBlast_PDB
86.66
26%
-85
- C5 -
1MDF
2
DHBE_BACSU
A:
[40-519]
-------------------------------------------------------------------------------------------
D
R
I
A
I
T
C
------
G
------
N
-----
T
H
W
S
Y
R
E
L
D
T
R
A
D
R
L
A
A
G
F
Q
-
K
L
G
I
Q
Q
K
D
R
V
V
V
Q
L
P
N
I
K
E
F
F
E
V
I
F
A
L
F
R
L
G
A
L
P
V
F
A
L
P
S
H
R
S
S
E
I
T
Y
F
C
E
F
A
E
A
A
A
Y
I
I
---------
P
D
A
Y
S
GFD
Y
R
S
L
A
-
R
Q
V
-
Q
----
S
----
K
---------
L
--
P
T
L
K
N
I
I
V
A
G
E
-
A
E
E
-------
F
L
P
L
--
E
D
L
H
----
T
E
-
P
V
K
------
L
-
P
--
E
--------
V
K
S
S
-
D
V
---
A
F
L
Q
L
S
G
G
S
T
G
L
S
K
L
I
P
R
T
H
D
D
------
Y
--
I
Y
S
L
K
R
S
V
E
V
C
W
-------------
L
D
H
S
T
V
Y
L
A
A
L
P
M
A
H
N
Y
P
L
S
S
-
P
G
V
L
G
-------------
V
L
Y
A
G
G
R
V
V
L
---
S
P
--
S
----
P
-
S
P
D
D
A
F
P
L
I
E
R
E
K
V
T
I
-----
T
A
L
V
P
P
L
A
M
V
W
M
----
D
A
A
S
S
-
R
R
D
--
D
L
S
S
L
Q
V
L
Q
V
G
G
A
---
K
F
S
A
E
A
A
R
R
V
-----------------------
K
A
V
-
F
G
C
T
------
L
Q
Q
V
F
G
--
M
---
A
---
E
G
-----
L
--
V
N
Y
T
-
R
-
L
-
D
DP
E
E
I
I
V
N
TQGKPMSPY
D
E
S
R
V
W
D
D
-
H
D
R
D
-----
V
K
P
-
G
E
--
T
G
H
L
L
T
----
R
----
G
P
Y
T
I
R
G
Y
Y
K
A
E
E
H
N
A
A
S
F
-
T
---
E
----
D
G
--
F
Y
R
T
G
D
I
V
R
L
T
R
D
G
Y
I
V
V
E
G
R
A
K
D
Q
I
N
R
G
G
E
K
V
A
A
E
E
V
E
N
H
L
L
A
H
P
A
V
H
D
A
A
M
V
S
M
P
D
Q
F
L
G
--
E
R
S
C
V
F
I
I
P
R
D
E
A
------
P
K
---
A
A
---
E
L
K
A
F
L
R
E
R
G
L
A
A
Y
K
-
I
P
D
R
V
E
F
V
E
S
F
P
Q
T
G
V
G
K
----------------------------
15
PsiBlast_PDB
86.19
24%
-83
- C5 -
4WV3
1
?
A:
[11-506]
-----------------------------------------------------------------------
N
A
V
D
I
L
-
E
R
N
L
-----
P
V
R
A
N
K
T
A
L
F
T
------
P
------
D
-----
R
E
M
T
F
R
Q
V
S
N
E
A
N
Q
V
G
N
A
L
K
-
G
L
G
V
R
F
G
E
C
V
G
L
L
T
L
D
S
A
E
W
V
T
S
F
F
G
I
V
K
L
G
A
I
A
V
G
I
N
T
L
L
K
P
P
E
Y
E
Y
I
L
R
D
C
R
A
R
V
L
I
V
---------
H
Q
E
F
L
-----
P
L
I
-
E
S
I
-
R
----
G
----
N
---------
L
--
P
M
L
E
H
I
V
V
I
G
-------
G
Y
-
L
S
F
N
D
W
I
R
P
Q
P
T
----
T
L
-
E
A
A
------
Q
-
S
--
H
---
R
E
--------
D
I
---
C
S
L
N
Y
S
S
G
-
T
G
G
P
K
G
I
P
H
A
H
K
D
Y
P
L
T
A
Q
L
--
W
G
V
N
V
L
G
L
R
E
S
D
-----
R
T
F
A
L
A
-
K
L
F
F
T
F
G
T
G
G
N
-------
L
I
-
F
-
P
W
Y
V
G
A
S
----------
C
V
L
F
P
G
A
A
R
V
----------------
A
S
N
V
L
S
T
I
S
R
F
K
P
T
I
F
Y
N
A
P
T
G
Y
A
A
A
L
----------
A
L
K
D
-
F
S
Q
H
-
D
L
S
S
L
R
L
C
V
S
A
S
E
---
A
L
P
A
A
L
W
Y
A
W
K
E
A
T
G
--
V
D
--
I
---
I
-
D
G
I
G
C
T
E
N
F
-
H
I
F
I
------
S
N
R
P
G
D
--
I
---
R
---
P
G
-----
S
--
S
G
K
P
-
V
-
E
-
G
-----------------
Y
E
L
K
L
V
D
D
-
E
G
K
T
-----
V
-
P
-
A
G
E
I
G
N
V
L
L
R
----
S
----
E
T
A
A
L
-
S
Y
W
H
N
F
E
K
S
R
Q
T
F
Q
G
-----------
E
W
L
A
T
G
D
K
Y
F
V
D
A
D
G
Y
Y
W
H
A
G
R
S
D
D
M
L
K
V
G
G
I
W
V
S
P
V
E
V
E
S
T
L
I
Q
H
P
A
V
Q
E
C
A
V
I
G
C
P
D
Q
S
R
L
--
I
K
P
K
A
F
I
I
L
K
P
E
Q
-----
I
P
S
---
E
A
L
I
R
Q
I
T
D
H
C
T
E
K
-
M
A
A
Y
K
-
R
P
R
W
I
E
F
V
T
E
L
P
K
T
A
T
G
K
----------------------------
6
PsiBlast_PDB
85.74
26%
-79
- C5 -
1MD9
2
DHBE_BACSU
A:
[40-519]
-------------------------------------------------------------------------------------------
D
R
I
A
I
T
C
------
G
------
N
-----
T
H
W
S
Y
R
E
L
D
T
R
A
D
R
L
A
A
G
F
Q
-
K
L
G
I
Q
Q
K
D
R
V
V
V
Q
L
P
N
I
K
E
F
F
E
V
I
F
A
L
F
R
L
G
A
L
P
V
F
A
L
P
S
H
R
S
S
E
I
T
Y
F
C
E
F
A
E
A
A
A
Y
I
I
---------
P
D
A
Y
S
GFD
Y
R
S
L
A
-
R
Q
V
-
Q
----
S
----
K
---------
L
--
P
T
L
K
N
I
I
V
A
G
E
-
A
E
E
-------
F
L
P
L
--
E
D
L
H
----
T
E
-
P
V
K
------
L
-
P
--
E
--------
V
K
S
S
-
D
V
---
A
F
L
Q
L
S
G
G
S
T
G
L
S
K
L
I
P
R
T
H
D
D
------
Y
--
I
Y
S
L
K
R
S
V
E
V
C
W
-----
L
D
H
S
-------
T
V
Y
L
A
A
L
P
M
A
H
N
-
Y
P
L
-
S
S
P
G
V
L
G
V
-------------
L
Y
A
G
G
R
V
V
L
---
S
P
--
S
----
P
-
S
P
D
D
A
F
P
L
I
E
R
E
K
V
T
I
-----
T
A
L
V
P
P
L
----
A
M
V
W
M
D
A
A
S
S
-
R
R
D
--
D
L
S
S
L
Q
V
L
Q
V
G
G
A
---
K
F
S
A
E
A
A
R
R
V
K
A
V
F
---
G
C
--
T
---
L
Q
Q
V
F
G
M
A
E
G
L
-
V
N
Y
T
RLDDP
E
E
I
I
V
N
T
--
Q
--------------
G
--
K
P
M
S
-
P
-
Y
-
D
-----------------
E
-
S
R
V
W
D
D
-
H
D
R
D
-----
V
K
P
-
G
E
T
--
G
H
L
L
T
----
R
----
G
P
Y
T
I
R
G
Y
Y
K
A
E
E
H
N
A
A
S
F
-
T
---
E
----
D
G
--
F
Y
R
T
G
D
I
V
R
L
T
R
D
G
Y
I
V
V
E
G
R
A
K
D
Q
I
N
R
G
G
E
K
V
A
A
E
E
V
E
N
H
L
L
A
H
P
A
V
H
D
A
A
M
V
S
M
P
D
Q
F
L
G
--
E
R
S
C
V
F
I
I
P
R
D
E
A
------
P
K
---
A
A
---
E
L
K
A
F
L
R
E
R
G
L
A
A
Y
K
-
I
P
D
R
V
E
F
V
E
S
F
P
Q
T
G
V
G
K
----------------------------
47
HHSearch
85.29
23%
-88
- C5 -
3C5E
7
ACS2A_HUMAN
A:
[41-562]
-------------------------------------------------------------------------
S
D
V
L
-
D
H
W
A
D
M
E
K
A
G
K
R
P
P
S
P
A
L
W
W
------
V
------
N
GKG
K
E
L
M
W
N
F
R
E
L
S
E
N
S
Q
Q
A
A
N
V
L
S
G
A
C
G
L
Q
R
G
D
R
V
A
V
V
L
P
R
V
P
E
W
W
L
V
I
L
G
C
I
R
A
G
L
I
F
M
P
G
T
I
Q
M
K
S
T
D
I
L
Y
R
L
Q
M
S
K
A
K
A
I
V
A
---------
G
D
E
V
I
-----
Q
E
V
-
D
T
V
-
A
----
S
----
E
---------
C
--
P
S
L
R
I
K
L
L
V
S
E
-
K
S
C
-------
D
G
W
L
--
N
F
K
K
----
L
L
-
N
E
A
------
S
-
T
T-
H
---
H
C
-
V
E
T
G
S
Q
-
E
A
---
S
A
I
Y
F
T
S
G
T
S
G
L
P
K
M
A
E
H
S
Y
S
S
------
L
--
G
L
K
A
K
M
D
A
--------------
G
-
W
T
G
------
L
Q
A
S
D
I
M
-
W
T
I
-
S
-
D
T
G
W
I
L
N
I
--
L
C-
S
-
L
M
E
P
W
A
L
G
A
C
T
F
V
H
L-
L
P
--
K
----
F
-
D
P
L
V
I
L
K
T
L
S
S
Y
P
I
K
S
M
M
G
A
P
I
V
Y
-
R
M
L
----
L
----
Q
Q
D
L
---
S
S
Y
-
K
F
P
H
L
Q
N
C
V
T
V
G
E
---
S
L
L
P
E
T
L
E
N
W
R
A
Q
T
---
G
L
--
D
---
I
R
E
S
Y
G
Q
T
E
T
G
-
L
T
C
M
------
V
S
K
T
M
---
K
---
I
---
K
P
-----
G
--
Y
M
G
T
-
A
A
S
-
C
-----------------
Y
D
V
Q
I
I
D
D
-
K
G
N
V
-----
L
P
P
-
G
T
E
G
D
I
G
I
R
V
KP
I
R
P
----
I
G
I
F
S
-
G
Y
V
D
N
P
D
K
T
A
A
N
I
R
-----------
G
D
F
W
L
L
G
D
R
G
I
K
D
E
D
G
Y
F
Q
F
M
G
R
A
D
D
I
I
N
S
S
G
Y
R
I
G
P
S
E
V
E
N
A
L
M
E
H
P
A
V
V
E
T
A
V
I
S
S
P
D
P
V
R
G
--
E
V
V
K
A
F
V
V
L
A
S
Q
F
LSHD
P
E
Q
L
---
T
K
---
E
L
Q
Q
H
V
K
S
V
-
T
A
P
Y
K
-
Y
P
R
K
I
E
F
V
L
N
L
P
K
T
V
T
G
K
I
Q
R
A
K
L
R
D
K
E
W
K
----------------
14
PsiBlast_PDB
84.99
25%
-72
- C5 -
3RG2
2
ENTB_ECOLI (first)
A:
[37-535]
----------------------------------------------------------------------------------------
A
A
S
D
S
I
A
V
I
D
------
G
------
E
-----
R
Q
L
S
Y
R
E
L
N
Q
A
A
D
N
L
A
C
S
L
R
-
R
Q
G
I
K
P
G
E
T
A
L
V
Q
L
G
N
V
A
E
L
Y
I
T
F
F
A
L
L
K
L
G
V
A
P
V
L
A
L
F
S
H
Q
R
S
E
L
N
A
Y
A
S
Q
I
E
P
A
L
L
I
A
---------
D
R
Q
H
A
LFSGD
D
F
L
-
N
T
F
-
V
----
T
----
E
---------
H
--
S
S
I
R
V
V
Q
L
L
N
D
-
S
G
E
H
-
N
L
-
Q
D
-----------------
A
I
N
------
H
-
P
--
A
---
E
D
-
F
T
A
T
P
S
-
P
A
DEV
A
Y
F
Q
L
S
G
G
T
T
G
T
P
K
L
I
P
R
T
H
N
D
------
Y
--
Y
Y
S
V
R
R
S
V
E
I
C
-------
Q
F
T
Q
Q
T
R
Y
L
C
A
I
P
A
A
H
N
---------------
Y
A
M
S
S
--
P
--
G
-
S
L
G
V
F
L
A
G
G
T
V
V
L
---
A
A
--
D
----
P
-
S
A
T
L
C
F
P
L
I
E
K
H
Q
V
N
V
T
A
L
V
P
P
A
V
S
L
W
L
---------
Q
A
L
I
E
-
G
E
S
R
A
Q
L
A
S
L
K
L
L
Q
V
G
G
A
---
R
L
S
A
T
L
A
A
R
I
----
P
--
A
E
--
I
G
C
Q
L
Q
Q
V
F
G
M
A
E
G
L
-
V
N
Y
T
------
R
L
D
D
S
A
--
E
---
K
I
I
-
H
T
-----
Q
--
G
Y
P
M
-
C
-
P
-
D
-----------------
D
E
V
W
V
A
D
A
-
E
G
N
P
-----
L
P
Q
-
G
E
V
G
R
-
L
M
T
R
----
G
----
P
Y
T
F
R
-
G
Y
Y
K
S
P
Q
H
N
A
S
A
F
D
A
--------
N
G
--
F
Y
C
S
G
D
L
I
S
I
D
P
E
G
Y
I
T
V
Q
G
R
E
K
D
Q
I
N
R
G
G
E
K
I
A
A
E
E
I
E
N
L
L
L
R
H
P
A
V
I
Y
A
A
L
V
S
M
E
D
E
L
M
G
--
E
K
S
C
A
Y
L
V
V
K
E
P
L
-----
R
A
-----
V
---
Q
V
R
R
F
L
R
E
Q
G
I
A
E
F
K
-
L
P
D
R
V
E
C
V
D
S
L
P
L
T
A
V
G
K
V
D
K
K
Q
L
R
Q
W
L
A
S
R
---------------
16
PsiBlast_PDB
83.86
23%
-80
- C5 -
1AMU
4
GRSA_ANEMI
A:
[41-525]
------------------------------------------------------------------------
I
H
Q
L
F
-
E
E
Q
V
-----
S
K
R
P
N
N
V
A
I
V
C
------
E
------
N
-----
E
Q
L
T
Y
H
E
L
N
V
K
A
N
Q
L
A
R
I
F
I
-
E
K
G
I
G
K
D
T
L
V
G
I
M
M
E
K
S
I
D
L
F
I
G
I
L
A
V
L
K
A
G
G
A
Y
V
P
I
D
I
E
Y
P
K
E
R
I
Q
Y
I
L
D
D
S
Q
A
R
M
L
L
T
---------
Q
K
H
L
V
-----
H
L
I
-
H
N
I
--------------------------------------------
Q
F
N
G
Q
V
--
E
I
F
E
EDTI
K
I
-
R
E
G
------
T
----
N
---
L
H
-
V
P
S
K
S
T
-
D
L
---
A
Y
V
I
Y
T
S
-----
P
K
G
T
M
L
E
H
K
G
------
I
S
N
L
K
V
F
F
E
N
S
L
N
V
T
EK
D
R
I
G
Q
F
A
S
I
-
S
F
D
-------------------------
A
S
V
--
W
--
E
-
M
F
M
A
L
L
T
G
A
S
L
Y
I
---
I
L
--
K
----
D
-
T
I
N
D
F
V
K
--
F
E
Q
Y
I
N
Q
K
E
I
T
V
I
T
L
P
P
T
Y
----
V
-------
V
H
-
L
D
P
E
-
R
I
L
S
I
Q
T
L
I
T
A
G
S
---
A
T
S
P
S
L
V
N
K
W
K
E
K
V
-------
T
---
Y
I
N
A
Y
G
P
T
E
T
T
-
I
C
A
T
------
T
W
V
A
T
K
--
E
---
T
---
I
G
HSVPI
G
--
A
P
-----
I
-
Q
-----------------
N
T
Q
I
Y
I
V
D
-
E
N
L
Q
-----
L
K
S
V
G
E
A
G
E
L
C
I
G
G
----
E
----
G
-
L
A
R
-
G
Y
W
K
R
P
E
L
T
S
Q
K
F
V
D
NPF
V
----
P
G
E
K
L
Y
K
T
G
D
Q
A
R
W
L
S
D
G
N
I
E
Y
L
G
R
I
D
N
Q
V
K
I
R
G
H
R
V
E
L
E
E
V
E
S
I
L
L
K
H
M
Y
I
S
E
T
A
V
S
V
H
K
D
H
Q
E
Q
--
P
Y
L
C
A
Y
F
V
S
E
K
H
I
-------
P
---
L
E
---
Q
L
R
Q
F
S
S
E
E
-
L
P
T
Y
M
-
I
P
S
Y
F
I
Q
L
D
K
M
P
L
T
S
N
G
K
I
D
R
K
Q
L
P
E
--------------------
63
Fugue
83.82
23%
-77
- C5 -
1PG4
7
ACSA_SALTY
A:
[5-647]
HKHAIP
A
N
I
A
D
RCLIN
P
E
Q
Y
E
T
K
Y
K
Q
S
I
N
D
P
D
T
F
W
G
E
Q
G
KILDWITPYQK
V
K
N
T
S
FAPG
N
V
S
I
K
W
Y
E
D
G
T
L
N
L
A
A
N
C
L
D
R
H
L
-----
Q
E
N
G
D
R
T
A
I
I
W
E
G
DDTS
Q
------
S
-----
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
-
D
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
C
I
I
D
S
S
S
R
L
V
I
T
A
D
E
G
V
R
AG
R
S
I
P
L
K
-----
K
N
V
-
D
D
A
-
L
----
K
----
N
---------
P
NV
T
S
V
E
H
V
I
V
L
K
R
T
G
S
D
I
-
D
W
-
Q
E
G
R
D
L
--
W
W
R
D
----
L
I
-
E
K
A
------
S
-
P
--
E
---
H
Q
-
P
E
A
M
N
A
E
D
P
---
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
------
Y
--
L
V
Y
A
A
T
T
F
K
Y
V
F
-----
D
Y
H
P
G
D
-
I
Y
W
C
T
------------
A
D
V
-
G
-
W
V
T
G
H
S
Y
------
L
-
L
Y
G
P
L
A
C
G
A
T
T
L
M
F
EG
V
P
--
N
----
W
P
T
P
A
R
M
C
Q
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
A
L
M
----
A
----
E
G
D
K
A
-
I
E
G
T
-
D
R
S
S
L
R
I
L
G
S
V
G
E
---
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
G
--
K
E
K
C
P
---
V
V
D
T
W
W
Q
T
E
T
G
G
F
M
I
T
------
P
L
P
G
A
I
--
E
---
L
---
K
A
-----
G
--
S
A
T
R
-
P
-
F
F
G
-----------------
V
Q
P
A
L
V
D
N
-
E
G
H
P
-----
Q
E
G
-
A
T
E
G
N
L
V
I
T
D
----
S
WP--
G
Q
A
R
T
-
L
F
G
D
H
E
R
F
E
Q
T
Y
F
S
T
---
F
----
K
N
--
M
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
--
Q
A
I
Y
A
Y
V
T
L
N
H
G
E
-----
E
P
S
P
E
L
Y
A
---
E
V
R
N
W
V
R
K
E
-
I
G
P
L
A
-
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
I
A
A
G
D
A
D
P
G
V
V
E
K
L
L
E
E
K
Q
A
58
HHSearch
83.81
25%
-78
- C5 -
4IZ6
2
ENTE_ECOLI
A:
[45-556]
----------------------------------------------------------------------
L
P
L
T
D
I
L
-
T
R
H
A
-----
A
--
S
D
S
I
A
V
I
D
------
G
------
E
-----
R
Q
L
S
Y
R
E
L
N
Q
A
A
D
N
L
A
C
S
L
R
-
R
Q
G
I
K
P
G
E
T
A
L
V
Q
L
G
N
V
A
E
L
Y
I
T
F
F
A
L
L
K
L
G
V
A
P
V
L
A
L
F
S
H
Q
R
S
E
L
N
A
Y
A
S
Q
I
E
P
A
L
L
I
A
---------
D
R
Q
H
A
-----
L
F
S
-
G
D
D
F
L
----
N
T
F
V
T
E
---------
H
--
S
S
I
R
V
V
Q
L
L
N
D
-
S
----------
G
E
H
--
N
L
Q
D
----
A
I
-
N
H
P
------
A
-
E
D-
F
---
T
A
-
T
P
S
P
A
D
-
E
V
---
A
Y
F
Q
L
S
G
G
-
T
G
T
P
K
L
I
P
R
T
H
N
D
------
Y
--
Y
Y
S
V
R
R
S
V
--------------
E
-
I
C
Q
------
F
T
Q
Q
T
R
Y
-
L
C
A
-
I
-
P
A
A
H
N
Y
A
M
--
S
SP
G
-
S
L
G
V
F
L
A
G
G
T
V
V
L
---
A
A
--
D
----
P
-
S
A
T
L
C
F
P
L
I
E
K
H
Q
V
N
V
T
A
L
V
P
P
A
V
S
L
-
W
----
L
----
Q
A
L
I
E
G
E
S
R
A
-
Q
L
A
S
L
K
L
L
Q
V
G
G
A
---
R
L
S
A
T
L
A
A
R
I
P
A
E
I
---
G
C
--
Q
---
L
Q
Q
V
F
G
M
A
E
G
L
-
V
N
Y
T
------
R
L
D
D
S
A
--
E
---
K
---
I
I
-----
H
T
Q
G
Y
P
M
-
C
-
P
-
D
-----------------
D
E
V
W
V
A
D
A
-
E
G
N
P
-----
L
P
Q
-
G
E
V
G
R
L
M
T
R
G
----
P
-----
Y
T
F
R
-
G
Y
Y
K
S
P
Q
H
N
A
S
A
F
D
----------
A
N
G
F
Y
C
S
G
D
L
I
S
I
D
P
E
G
Y
I
T
V
Q
G
R
E
K
D
Q
I
N
R
G
G
E
K
I
A
A
E
E
I
E
N
L
L
L
R
H
P
A
V
I
Y
A
A
L
V
S
M
E
D
E
L
M
G
--
E
K
S
C
A
Y
L
V
V
K
E
P
-------
L
R
---
A
V
---
Q
V
R
R
F
L
R
E
Q
G
I
A
E
F
K
-
L
P
D
R
V
E
C
V
D
S
L
P
L
T
A
V
G
K
V
D
K
K
Q
L
R
Q
W
L
A
S
----------------
13
PsiBlast_PDB
83.41
25%
-72
- C5 -
4IZ6
2
ENTE_ECOLI
A:
[55-557]
----------------------------------------------------------------------------------------
A
A
S
D
S
I
A
V
I
D
------
G
------
E
-----
R
Q
L
S
Y
R
E
L
N
Q
A
A
D
N
L
A
C
S
L
R
-
R
Q
G
I
K
P
G
E
T
A
L
V
Q
L
G
N
V
A
E
L
Y
I
T
F
F
A
L
L
K
L
G
V
A
P
V
L
A
L
F
S
H
Q
R
S
E
L
N
A
Y
A
S
Q
I
E
P
A
L
L
I
A
---------
D
R
Q
H
A
LFSGD
D
F
L
-
N
T
F
-
V
----
T
----
E
---------
H
--
S
S
I
R
V
V
Q
L
L
N
D
-
S
G
E
H
-
N
L
-
Q
D
-----------------
A
I
N
------
H
-
P
--
A
---
E
D
-
F
T
A
T
P
S
-
P
A
DEV
A
Y
F
Q
L
S
G
G
-
T
G
T
P
K
L
I
P
R
T
H
N
D
------
Y
--
Y
Y
S
V
R
R
S
V
E
I
C
-------
Q
F
T
Q
Q
T
R
Y
L
C
A
I
P
A
A
H
N
---------------
Y
A
M
S
S
--
P
--
G
-
S
L
G
V
F
L
A
G
G
T
V
V
L
---
A
A
--
D
----
P
-
S
A
T
L
C
F
P
L
I
E
K
H
Q
V
N
V
T
A
L
V
P
P
A
V
S
L
W
L
---------
Q
A
L
I
E
-
G
E
S
R
A
Q
L
A
S
L
K
L
L
Q
V
G
G
A
---
R
L
S
A
T
L
A
A
R
I
----
P
--
A
E
--
I
G
C
Q
L
Q
Q
V
F
G
M
A
E
G
L
-
V
N
Y
T
------
R
L
D
D
S
A
--
E
---
K
I
I
-
H
T
-----
Q
--
G
Y
P
M
-
C
-
P
-
D
-----------------
D
E
V
W
V
A
D
A
-
E
G
N
P
-----
L
P
Q
-
G
E
V
G
R
-
L
M
T
R
----
G
----
P
Y
T
F
R
-
G
Y
Y
K
S
P
Q
H
N
A
S
A
F
D
A
--------
N
G
--
F
Y
C
S
G
D
L
I
S
I
D
P
E
G
Y
I
T
V
Q
G
R
E
K
D
Q
I
N
R
G
G
E
K
I
A
A
E
E
I
E
N
L
L
L
R
H
P
A
V
I
Y
A
A
L
V
S
M
E
D
E
L
M
G
--
E
K
S
C
A
Y
L
V
V
K
E
P
L
-----
R
A
-----
V
---
Q
V
R
R
F
L
R
E
Q
G
I
A
E
F
K
-
L
P
D
R
V
E
C
V
D
S
L
P
L
T
A
V
G
K
V
D
K
K
Q
L
R
Q
W
L
A
S
R
---------------
52
HHSearch
82.17
21%
-92
- C5 -
4ZXH
-
?
A:
[483-966]
------------------------------------------------------------------------
L
F
A
M
I
-
L
K
Q
I
-----
D
E
R
G
D
N
H
A
L
T
S
-------------------
H
T
V
S
Y
R
E
L
G
Q
H
I
A
G
I
A
E
Y
L
R
-
A
H
G
I
T
Q
G
D
R
V
G
L
M
L
D
R
T
A
L
L
P
A
A
I
L
G
I
W
A
A
G
A
A
Y
V
P
L
D
P
N
F
P
T
E
R
L
Q
N
I
I
E
D
A
E
P
K
V
I
L
T
---------
Q
T
E
L
M
-----
D
G
L
-
N
V
S
-
V
--------------------------
P
R
L
D
I
N
Q
-
A
G
---------------
V
-------
V
---
A
------
L
-
E
--
Q
---
V
R
-
E
T
L
A
F
G
-
D
I
---
A
Y
V
M
Y
T
S
----
K
P
K
G
V
R
I
G
H
P
S
------
I
--
I
N
F
L
L
S
M
N
--------------
D
-
R
L
------
Q
V
T
T
E
T
Q
L
-
L
A
I
-
T
-
T
Y
A
F
D
I
S
I
--
L
--
E
-
L
L
I
P
L
M
Y
G
G
V
V
H
V
---
C
P
--
R
E
V
S
-
Q
-
D
G
I
Q
L
V
D
Y
L
N
A
K
S
I
N
V
L
Q
A
T
P
A
T
W
K
-
M
L
----
L
----
D
S
E
------
W
-
S
G
N
A
G
L
T
A
L
C
G
G
E
---
A
L
D
T
I
L
A
E
K
L
L
G
K
V
----
G
--
C
---
L
W
N
V
Y
G
P
T
E
T
T
-
V
W
S
S
------
A
A
R
I
T
D
--
A
---
K
YI-
D
L
-----
G
--
E
P
---
L
-
A
-
N
-----------------
T
Q
L
Y
V
L
D
E
-
Q
Q
R
L
-----
V
P
P
-
G
V
M
G
E
L
W
I
G
G
----
D
-----
G
L
A
V
-
D
Y
W
Q
R
P
E
L
T
D
A
Q
F
R
T
---
L
PSLP
N
A
G
R
L
Y
R
T
G
D
K
V
C
L
R
T
D
G
R
L
T
H
H
G
R
L
D
F
Q
V
K
I
R
G
F
R
I
E
L
G
E
I
E
N
V
L
K
Q
I
D
G
I
T
D
A
V
V
L
V
K
T
T
G
D
N
D
--
Q
K
L
V
A
Y
V
T
G
Q
E
--------
L
D
---
I
A
---
G
L
K
K
N
L
Q
I
H
-
L
P
A
Y
M
-
V
P
S
A
F
I
R
L
D
E
F
P
M
T
A
N
K
K
L
D
R
K
A
F
P
E
P
I
F
E
----------------
37
HHSearch
81.48
22%
-79
- C5 -
1PG4
7
ACSA_SALTY
A:
[78-632]
------------------------------------------------------------------------
A
A
N
C
L
-
D
R
H
L
-----
Q
E
N
G
D
R
T
A
I
I
W
------
E
G
DDTS
Q
S
-----
K
H
I
S
Y
R
E
L
H
R
D
V
C
R
F
A
N
T
L
L
-
D
L
G
I
K
K
G
D
V
V
A
I
Y
M
P
M
V
P
E
A
A
V
A
M
L
A
C
A
R
I
G
A
V
H
S
V
I
F
G
G
F
S
P
E
A
V
A
G
C
I
I
D
S
S
S
R
L
V
I
T
---------
A
D
E
G
V
-----
R
A
G
-
R
S
I
-
P
L
K
--
K
----
N
V
D
D
A
L
K
NPN
V
--
T
S
V
E
H
V
I
V
L
K
R
-
T
G
S
D
I
D
W
-
Q
E
G
R
D
L
--
W
W
R
D
----
L
I
-
E
K
A
------
S
-
P
--
E
H
--
Q
P
-
E
A
M
N
A
E
-
D
P
---
L
F
I
L
Y
T
S
G
S
T
G
K
P
K
G
V
L
H
T
T
G
G
------
Y
--
L
V
Y
A
A
T
T
F
-------------
K
Y
-
V
F
------
D
Y
H
P
G
D
I
Y
-
W
C
T
-
A
-
D
V
G
W
V
T
G
H
S
-
Y
--
L
-
L
Y
G
P
L
A
C
G
A
T
T
L
M
---
F
E
--
G
VPNW
P
-
T
P
A
R
M
C
Q
V
V
D
K
H
Q
V
N
I
L
Y
T
A
P
T
A
I
R
-
A
L
----
M
----
A
E
G
D
K
A
I
E
G
T
-
D
R
S
S
L
R
I
L
G
S
V
G
E
---
P
I
N
P
E
A
W
E
W
Y
W
K
K
I
G
KE
K
C
--
P
---
V
V
D
T
W
W
Q
T
E
T
G
-
G
F
M
I
------
T
P
L
P
G
A
I
-
E
---
L
---
K
A
-----
G
--
S
A
T
R
-
P
F
F
-
G
-----------------
V
Q
P
A
L
V
D
N
-
E
G
H
P
-----
Q
E
G
-
A
T
E
G
N
L
V
I
T
D
----
S
W---
P
G
Q
A
R
-
T
L
F
G
D
H
E
R
F
E
Q
T
Y
F
S
--------
T
F
K
N
M
Y
F
S
G
D
G
A
R
R
D
E
D
G
Y
Y
W
I
T
G
R
V
D
D
V
L
N
V
S
G
H
R
L
G
T
A
E
I
E
S
A
L
V
A
H
P
K
I
A
E
A
A
V
V
G
I
P
H
A
I
K
G
--
Q
A
I
Y
A
Y
V
T
L
N
H
G
E
E
P
S
--
P
E
L
---
Y
A
---
E
V
R
N
W
V
R
K
E
-
I
G
P
L
A
-
T
P
D
V
L
H
W
T
D
S
L
P
K
T
R
S
G
K
I
M
R
R
I
L
R
K
I
A
A
G
D
---------------
39
HHSearch
80.63
22%
-86
- C5 -
3ETC
11
?
A:
[57-559]
-----------------------------------------------------------------------
F
A
Y
D
V
V
-
D
V
Y
A
-----
R
D
S
P
E
K
L
A
M
I
W
------
C
D
DYG
N
-
E
-----
K
I
F
T
F
K
D
L
K
Y
Y
S
D
K
A
A
N
F
F
V
-
K
H
G
I
G
K
G
D
Y
V
M
L
T
L
K
S
R
Y
D
F
W
Y
C
M
L
G
L
H
K
L
G
A
I
A
V
P
A
T
H
M
L
K
T
R
D
I
V
Y
R
I
E
K
A
G
L
K
M
I
V
C
---------
I
A
E
D
D
V
P
---
E
Q
V
-
D
E
A
-
H
----
A
----
E
---------
C
--
G
D
I
P
-
L
K
K
A
K
V
-
G
G
D
--
V
L
---
E
G
W
I
--
D
F
R
K
----
E
L
-
E
E
S
SPIFE-
R
-
P
--
T
---
G
E
-
V
S
T
K
N
E
-
D
I
---
C
L
V
Y
F
S
S
G
T
A
G
F
P
K
M
V
E
H
D
N
T
Y
------
P
--
L
G
H
I
L
T
A
K
--------------
Y
-
W
Q
N
------
V
E
D
D
G
L
H
-
Y
T
V
-
A
-
D
S
G
W
G
K
C
V
--
W
--
G
K
L
Y
G
Q
W
I
A
G
C
A
V
F
V
---
Y
D
YD
R
----
F
-
E
A
K
N
M
L
E
K
A
S
K
Y
G
V
T
T
F
C
A
P
P
T
I
Y
R
-
F
L
----
I
----
K
E
D
L
-------
N
F
S
T
L
K
Y
A
V
V
A
G
E
---
P
L
N
P
E
V
F
N
R
F
L
E
F
-
T
--
G
I
--
K
---
L
M
E
G
F
G
Q
T
E
T
V
-
V
T
I
A
------
T
F
P
W
M
---
E
---
P
---
K
P
-----
G
--
S
I
G
K
P
T
-
P
-
G
-----------------
Y
K
I
E
L
M
D
R
-
D
G
R
L
-----
C
E
V
-
G
E
E
G
E
I
V
I
N
T
----
M
EGKP
V
G
L
F
V
-
H
Y
G
K
D
P
E
R
T
E
E
T
W
H
-----------
D
G
Y
Y
H
T
G
D
M
A
W
M
D
E
D
G
Y
L
W
F
V
G
R
A
D
D
I
I
K
T
S
G
Y
K
V
G
P
F
E
V
E
S
A
L
I
Q
H
P
A
V
L
E
C
A
I
T
G
V
P
D
P
V
R
G
--
Q
V
I
K
A
T
I
V
L
T
K
D
Y
T
P
S
--
D
S
L
---
K
N
---
E
L
Q
D
H
V
K
N
V
-
T
A
P
Y
K
-
Y
P
R
I
I
E
F
V
P
E
------------------------------------
49
HHSearch
80.55
22%
-91
- C5 -
2VSQ
2
A:
[464-976]
----------------------------------------------------------------------
K
P
L
T
Y
W
F
-
K
E
A
V
-----
N
A
N
P
D
A
P
A
L
T
Y
------
S
------
G
-----
Q
T
L
S
Y
R
E
L
D
E
E
A
N
R
I
A
R
R
L
Q
-
K
H
G
A
G
K
G
S
V
V
A
L
Y
T
K
R
S
L
E
L
V
I
G
I
L
G
V
L
K
A
G
A
A
Y
L
P
V
D
P
K
L
P
E
D
R
I
S
Y
M
L
A
D
S
A
A
A
C
L
L
T
---------
H
Q
E
M
K
-----
E
Q
A
-
A
E
L
-
P
----
Y
-------------------
T
G
T
T
L
F
I
D
D
-
Q
T
---------------
R
F
E
--------
E
Q
------
A
-
S
--
D
---
P
A
-
T
A
I
D
P
N
-
D
P
---
A
Y
I
M
Y
T
S
G
T
T
G
K
P
K
G
N
I
T
T
H
A
N
------
I
--
Q
G
L
V
K
H
V
---------------
D
-
Y
M
A
------
F
S
D
Q
D
T
F
-
L
S
V
-
S
-
N
Y
A
F
D
A
F
T
--
F
--
D
-
F
Y
A
S
M
L
N
A
A
R
L
I
I
---
A
D
--
E
HTL-
L
-
D
T
E
R
L
T
D
L
I
L
Q
E
N
V
N
V
M
F
A
T
T
A
L
F
-
N
L
L
----
T
----
D
A
-----
G
E
D
-
W
M
K
G
L
R
C
I
L
F
G
G
E
---
R
A
S
V
P
H
V
R
K
A
L
R
I
M
G
--
P
G
--
K
---
L
I
N
C
Y
G
P
T
E
G
T
-
V
F
A
T
------
A
H
V
V
H
D
--
L
PDS
I
---
S
S
-----
L
--
P
I
G
K
-
P
I
S
-
N
-----------------
A
S
V
Y
I
L
N
E
-
Q
S
Q
L
-----
Q
P
F
-
G
A
V
G
E
L
C
I
S
G
----
M
-----
G
V
S
K
-
G
Y
V
N
R
A
D
L
T
K
E
K
F
I
E
---
N
PFK-
P
G
E
T
L
Y
R
T
G
D
L
A
R
W
L
P
D
G
T
I
E
Y
A
G
R
I
D
D
Q
V
K
I
R
G
H
R
I
E
L
E
E
I
E
K
Q
L
Q
E
Y
P
G
V
K
D
A
V
V
V
A
D
R
H
E
S
G
D
--
A
S
I
N
A
Y
L
V
N
R
T
Q
-------
L
S
---
A
E
---
D
V
K
A
H
L
K
K
Q
-
L
P
A
Y
M
-
V
P
Q
T
F
T
F
L
D
E
L
P
L
T
T
N
G
K
V
N
K
R
L
L
P
K
P
D
Q
-----------------
59
HHSearch
78.88
26%
-97
- C5 -
3IVR
5
?
A:
[6-397]
----------------------------------------------------------------------
F
T
L
A
D
V
Y
-
R
R
N
A
-----
A
L
F
P
D
R
T
A
F
M
V
------
D
------
G
-----
V
R
L
T
H
R
D
Y
L
A
R
A
E
R
L
A
S
G
L
L
-
R
D
G
V
H
T
G
D
R
V
A
I
L
S
Q
N
C
S
E
M
I
E
L
I
G
A
V
A
L
I
G
A
I
L
L
P
V
N
Y
R
L
N
A
D
E
I
A
F
V
L
G
D
G
A
P
S
V
V
V
A
---------
G
T
D
Y
R
-----
D
I
V
-
A
G
V
-
L
----
P
----
S
---------
L
--
G
G
V
K
K
A
Y
A
I
G
D
-
G
S
G
--------
P
F
A
--
P
F
K
D
----
L
A
-
S
-
D
------
T
-
P
--
F
---
S
A
-
P
E
F
G
A
A
-
D
G
---
F
V
I
I
H
T
A
A
--
G
R
P
R
G
A
L
I
S
Q
G
N
------
L
--
L
I
A
Q
S
S
L
--------------
V
D
-
A
W
R
------
L
T
E
A
D
V
N
-
L
G
M
-
L
-
P
L
F
H
V
T
G
L
--
G
--
L
-
M
L
T
L
Q
Q
A
G
G
A
S
V
I
---
A
A
--
K
----
F
-
D
P
A
Q
A
A
R
D
I
E
A
H
K
V
T
V
M
A
E
F
A
P
M
L
G
-
N
I
----
L
----
D
Q
A
----
A
P
A
-
Q
L
A
S
L
R
A
V
T
--
G
L
----
D
T
P
E
T
I
E
R
F
E
A
T
C
P
--
N
A
--
T
---
F
W
A
T
F
G
Q
S
E
T
S
-
G
L
S
T
------
F
A
P
Y
R
-------
D
---
R
P
-----
K
--
S
A
G
R
P
L
-
F
-
W
-----------------
R
T
V
A
V
V
D
A
-
E
D
R
P
-----
L
P
P
-
G
E
V
G
E
I
V
L
R
G
----
P
-----
T
V
F
K
-
G
Y
W
N
N
A
A
A
T
Q
H
A
F
R
-----------
N
G
W
H
H
T
G
D
M
G
R
F
D
A
D
G
Y
L
F
Y
A
G
R
A
-------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
78.71
27%
-91
- C5 -
3IVR
5
?
A:
[6-397]
----------------------------------------------------------------------
F
T
L
A
D
V
Y
-
R
R
N
A
-----
A
L
F
P
D
R
T
A
F
M
V
------
D
------
G
-----
V
R
L
T
H
R
D
Y
L
A
R
A
E
R
L
A
S
G
L
L
-
R
D
G
V
H
T
G
D
R
V
A
I
L
S
Q
N
C
S
E
M
I
E
L
I
G
A
V
A
L
I
G
A
I
L
L
P
V
N
Y
R
L
N
A
D
E
I
A
F
V
L
G
D
G
A
P
S
V
V
V
A
---------
G
T
D
Y
R
-----
D
I
V
-
A
G
V
-
L
----
P
----
S
---------
L
--
G
G
V
K
K
A
Y
A
I
G
D
-
G
S
---------
G
P
F
--
A
P
F
K
----
D
L
-
A
S
D
------
T
-
P
F
S
A
---
P
E
-
F
G
--
A
A
-
D
G
---
F
V
I
I
H
T
A
A
--
G
R
P
R
G
A
L
-----------------------
I
S
Q
-----
G
N
L
L
I
A
-
Q
S
S
L
V
D
A
W
R
L
T
E
A
D
V
N
-
L
G
M
-
L
-
P
L
F
H
V
T
G
L
--
G
--
L
-
M
L
T
L
Q
Q
A
G
G
A
S
V
I
---
A
A
--
K
----
F
-
D
P
A
Q
A
A
R
D
I
E
A
H
K
V
T
V
M
-----
A
E
F
A
P
M
----
L
----------
G
N
I
L
-
D
Q
A
A
P
A
Q
L
A
S
L
R
A
V
T
G
L
D
T
P
E
T
I
E
R
F
E
A
T
C
P
--
N
A
--
T
---
F
W
A
T
F
G
Q
S
E
T
S
---
G
L
------
S
T
F
A
P
Y
--
R
---
D
---
R
P
-----
K
--
S
A
G
R
-
P
-
L
-
F
-----------------
W
R
T
V
A
V
V
D
-
A
E
D
R
-----
P
L
P
-
P
G
E
V
G
E
I
V
L
R
----
G
----
P
T
V
F
K
-
G
Y
W
N
N
A
A
A
T
Q
H
A
F
R
---------
N
G
W
H
H
T
--
G
D
M
G
R
F
D
A
D
G
Y
L
F
Y
A
G
R
A
-------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
78.48
16%
-81
- C5 -
4OXI
1
?
A:
[52-570]
-----------------------------------------------------------------------
T
R
H
S
I
L
-
A
A
-
I
-----
Q
A
N
R
H
A
P
A
L
W
V
------
K
------
Q
-----
K
T
Y
T
Y
Q
E
M
T
D
M
A
L
S
L
S
D
Y
W
H
-
L
Q
G
V
Q
---
R
V
A
I
L
S
V
R
D
L
A
A
Y
S
A
I
W
A
S
Y
L
G
G
M
T
Y
I
P
L
N
A
R
A
T
T
E
Q
I
Q
E
T
L
I
A
T
Q
C
D
S
I
M
V
---------
D
A
Q
Q
L
-----
S
R
L
-
S
S
L
-
L
----
E
----
T
---------
C
--
I
D
R
L
H
I
Y
A
L
P
D
-
V
D
V
E
-
P
L
R
Q
Q
Y
P
Q
H
--
T
F
H
T
----
V
Q
I
T
E
Q
D
-----
V
-
E
--
L
LVV
K
Y
--
L
D
N
E
H
-
E
Y
---
A
Y
I
M
Q
T
S
G
S
T
G
K
P
K
R
I
A
V
S
Y
S
N
------
L
--
H
C
Y
I
S
Q
I
D
--------------
K
-
L
F
P
------
L
N
A
Q
D
R
V
-
G
Q
Y
-
S
-
D
L
T
F
D
L
S
V
--
H
--
D
-
I
F
Y
S
L
I
S
G
A
C
L
Y
V
---
V
P
--
E
----
L
-
A
K
L
S
P
A
E
F
I
H
H
H
Q
L
T
V
W
L
S
V
P
T
V
I
E
-
L
A
----
L
----
Q
R
Q
T
L
--
T
P
H
-
S
L
P
S
L
R
L
S
F
F
C
G
Q
---
A
L
L
H
D
L
A
E
Q
W
Q
Q
A
T
---
Q
Q
--
P
---
V
I
N
L
Y
G
P
T
E
C
T
-
I
A
V
T
------
Y
H
R
F
V
A
HS
G
---
M
---
A
S
-----
V
--
P
I
G
R
-
A
F
E
-
E
-----------------
E
C
L
A
I
I
N
E
-
Q
G
E
L
M
R
FES
A
P
E
-
G
Y
R
G
E
L
L
L
S
G
----
K
-----
Q
L
V
K
-
G
Y
L
N
D
P
L
N
T
Q
S
A
F
F
Q
---
H
----
E
G
R
L
W
Y
R
S
G
D
I
V
T
K
-
S
N
G
V
L
I
H
L
G
R
R
D
H
Q
V
K
I
A
G
Q
R
V
E
L
E
E
I
E
T
V
V
R
R
V
T
Q
A
H
S
V
A
I
V
P
W
P
L
S
E
S
G
YA
S
G
T
V
A
F
V
D
T
H
T
Q
-------
W
Q
---
P
D
---
L
W
L
S
Q
C
K
Q
Q
-
L
N
P
T
F
-
V
P
K
R
W
Y
A
I
E
Q
L
P
R
----
K
T
D
I
K
A
L
Q
Q
Q
L
A
S
Q
---------------