@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3534c: (2016-05-20 )
MTDMWDVRITDTSLRDGSHHKRHQFTKDEVGAIVAALDAAGVPVIEVTHGDGLGGSSFNYGFSKTPEQELIKLAAATAKEARIAFLMLPGVGTKDDIKEARDNGGSICRIATHCTEADVSIQHFGLARELGLETVGFLMMAHTIAPEKLAAQARIMADAGCQCVYVVDSAGALVLDGVADRVSALVAELGEDAQVGFHGHENLGLGVANSVAAVRAGAKQIDGSCRRFGAGAGNAPVEALIGVFDKIGVKTGIDFFDIADAAEDVVRPAMPAECLLDRNALIMGYSGVYSSFLKHAVRQAERYGVPASALLHRAGQRKLIGGQEDQLIDIALEIKRELDSGAAVTH
Atome Classification :
(20 SA)
-.........10........20.-.......30......-..40.......-------------.50....----....60........70.......------.------80........----90..-...-----.----..100----.......110....--------------.--------------.--------------.120.......130......--.140-----.---.......150.......160.......170.......180.......190-........200.......210.......220------.......230----.........240....----...250.......260.......270-..---.......280.......290.......300...---------....310.......320.......330.......340....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-MTD
M
W
D
V
R
I
TDTSLRDGSH
H
K
R-HQF
T
K
D
E
V
G
A
I
V
A
A
L
-DAAG
V
P
V
I
E
V
T-------------HGDGLGG----SSFNYGFSKT
P
E
Q
E
L
I
K
L
A
A
ATA------K------E
A
R
I
A
F
L
MLP----GVG
T
-
K
D
D
-----
I
----
K
E
A
RD----NGG
S
I
C
R
I
ATHCTE--------------A--------------D--------------V
S
I
Q
H
F
G
L
A
R
E
L
G
L
E
T
V
G
F
L
--
M
M
A
------H---TI
A
P
E
K
L
A
A
Q
A
R
I
M
ADAG
C
Q
C
V
Y
V
VDSAG
A
L
V
L
D
G
V
A
D
R
V
S
A
L
V
A
ELGE--DA
Q
V
GFHGHENLG
L
G
V
A
N
S
V
A
A
V
R
A
G
A
K
QID------G
S
C
R
RFGA------GAGN
A
P
V
E
A
L
I
G
V
F
D
K
----IGVKTGI
D
F
F
D
I
A
D
A
A
E
D
V
VRPAM---
P
A
---
E
C
L
LDRN
A
L
I
M
GY
S
G
V
Y
S
S
F
L
K
H
A
V
R
Q
A
E
RYGV---------
P
A
S
A
L
L
H
RAGQRKLIGGQED
Q
L
I
D
I
A
L
E
I
K
R
E
LDSGAAVTH
27
HHSearch
99.69
100%
-99
- C2 -
4JN6
2
HOA_MYCTU
A:
[4-341]
----
M
W
D
V
R
I
T
D
T
S
L
R
D
G
S
H
H
K
R
-
H
Q
F
T
K
D
E
V
G
A
I
V
A
A
L
-
D
A
A
G
V
P
V
I
E
V
T
-------------
H
G
D
G
L
G
G
----
S
S
F
N
Y
G
F
S
K
T
P
E
Q
E
L
I
K
L
A
A
A
T
A
------
K
------
E
A
R
I
A
F
L
M
L
P
----
G
V
G
T
-
K
D
D
-----
I
----
K
E
A
R
D
----
N
G
G
S
I
C
R
I
A
T
H
C
T
E
--------------
A
--------------
D
--------------
V
S
I
Q
H
F
G
L
A
R
E
L
G
L
E
T
V
G
F
L
--
M
M
A
------
H
---
T
I
A
P
E
K
L
A
A
Q
A
R
I
M
A
D
A
G
C
Q
C
V
Y
V
V
D
S
A
G
A
L
V
L
D
G
V
A
D
R
V
S
A
L
V
A
E
L
G
E
--
D
A
Q
V
G
F
H
G
H
E
N
L
G
L
G
V
A
N
S
V
A
A
V
R
A
G
A
K
Q
I
D
------
G
S
C
R
R
F
G
A
------
G
A
G
N
A
P
V
E
A
L
I
G
V
F
D
K
----
I
G
V
K
T
G
I
D
F
F
D
I
A
D
A
A
E
D
V
V
R
P
A
M
---
P
A
---
E
C
L
L
D
R
N
A
L
I
M
G
Y
S
G
V
Y
S
S
F
L
K
H
A
V
R
Q
A
E
R
Y
G
V
---------
P
A
S
A
L
L
H
R
A
G
Q
R
K
L
I
G
G
Q
E
D
Q
L
I
D
I
A
L
E
I
K
R
E
L
D
S
G
-----
1
PsiBlast_PDB
99.45
100%
-99
- C2 -
4JN6
2
HOA_MYCTU
A:
[4-341]
----
M
W
D
V
R
I
T
D
T
S
L
R
D
G
S
H
H
K
R
-
H
Q
F
T
K
D
E
V
G
A
I
V
A
A
L
-
D
A
A
G
V
P
V
I
E
V
T
-------------
H
G
D
G
L
G
G
----
S
S
F
N
Y
G
F
S
K
T
P
E
Q
E
L
I
K
L
A
A
A
T
A
------
K
------
E
A
R
I
A
F
L
M
L
P
----
G
V
G
T
-
K
D
D
-----
I
----
K
E
A
R
D
----
N
G
G
S
I
C
R
I
A
T
H
C
T
E
--------------
A
--------------
D
--------------
V
S
I
Q
H
F
G
L
A
R
E
L
G
L
E
T
V
G
F
L
--
M
M
A
------
H
---
T
I
A
P
E
K
L
A
A
Q
A
R
I
M
A
D
A
G
C
Q
C
V
Y
V
V
D
S
A
G
A
L
V
L
D
G
V
A
D
R
V
S
A
L
V
A
E
L
G
E
--
D
A
Q
V
G
F
H
G
H
E
N
L
G
L
G
V
A
N
S
V
A
A
V
R
A
G
A
K
Q
I
D
------
G
S
C
R
R
F
G
A
------
G
A
G
N
A
P
V
E
A
L
I
G
V
F
D
K
----
I
G
V
K
T
G
I
D
F
F
D
I
A
D
A
A
E
D
V
V
R
P
A
M
---
P
A
---
E
C
L
L
D
R
N
A
L
I
M
G
Y
S
G
V
Y
S
S
F
L
K
H
A
V
R
Q
A
E
R
Y
G
V
---------
P
A
S
A
L
L
H
R
A
G
Q
R
K
L
I
G
G
Q
E
D
Q
L
I
D
I
A
L
E
I
K
R
E
L
D
S
G
-----
21
PsiBlast_CBE
99.18
100%
-98
- C2 -
4JN6
3
HOA_MYCTU
C:
[4-342]
----
M
W
D
V
R
I
T
D
T
S
L
R
D
G
S
H
H
K
R
-
H
Q
F
T
K
D
E
V
G
A
I
V
A
A
L
-
D
A
A
G
V
P
V
I
E
V
T
-------------
H
G
D
G
L
G
G
----
S
S
F
N
Y
G
F
S
K
T
P
E
Q
E
L
I
K
L
A
A
A
T
A
------
K
------
E
A
R
I
A
F
L
M
L
P
----
G
V
G
T
-
K
D
D
-----
I
----
K
E
A
R
D
----
N
G
G
S
I
C
R
I
A
T
H
C
T
E
--------------
A
--------------
D
--------------
V
S
I
Q
H
F
G
L
A
R
E
L
G
L
E
T
V
G
F
L
--
M
M
A
------
H
---
T
I
A
P
E
K
L
A
A
Q
A
R
I
M
A
D
A
G
C
Q
C
V
Y
V
V
D
S
A
G
A
L
V
L
D
G
V
A
D
R
V
S
A
L
V
A
E
L
G
E
--
D
A
Q
V
G
F
H
G
H
E
N
L
G
L
G
V
A
N
S
V
A
A
V
R
A
G
A
K
Q
I
D
------
G
S
C
R
R
F
G
A
------
G
A
G
N
A
P
V
E
A
L
I
G
V
F
D
K
----
I
G
V
K
T
G
I
D
F
F
D
I
A
D
A
A
E
D
V
V
R
P
A
M
---
P
A
---
E
C
L
L
D
R
N
A
L
I
M
G
Y
S
G
V
Y
S
S
F
L
K
H
A
V
R
Q
A
E
R
Y
G
V
---------
P
A
S
A
L
L
H
R
A
G
Q
R
K
L
I
G
G
Q
E
D
Q
L
I
D
I
A
L
E
I
K
R
E
L
D
S
G
A
----
2
PsiBlast_PDB
83.77
62%
-91
- C2 -
4LRS
11
?
A:
[13-343]
-------
V
R
I
T
D
S
T
L
R
D
G
S
H
A
M
A
-
H
Q
F
T
E
E
Q
V
R
A
T
V
H
A
L
-
D
A
A
G
V
E
V
I
E
V
S
-------------
H
G
D
G
L
G
G
----
S
S
F
N
Y
G
F
S
A
V
D
E
I
D
L
V
A
A
A
V
D
E
A
------
V
------
N
A
K
I
A
V
L
L
L
P
----
G
V
G
T
-
V
R
D
-----
L
----
K
R
A
H
D
----
A
G
A
S
V
A
R
I
A
T
H
C
T
E
--------------
A
--------------
D
--------------
V
S
C
Q
H
F
A
A
A
R
E
L
G
M
E
T
V
G
F
L
--
M
L
A
------
H
---
R
I
G
P
E
E
L
A
R
Q
A
R
I
M
V
D
A
G
A
Q
C
V
Y
V
V
D
S
A
G
A
L
V
L
S
D
V
Q
A
R
V
Q
A
L
V
R
E
I
G
H
--
E
A
Q
V
G
F
H
G
H
Q
N
L
S
L
G
V
A
N
S
V
L
A
Y
Q
N
G
A
R
Q
I
D
------
G
A
L
C
A
L
G
A
------
G
A
G
N
S
P
T
E
I
L
A
A
T
F
E
R
----
L
N
I
E
T
G
V
N
V
Q
A
A
L
A
A
A
E
E
V
V
R
P
Y
L
---
P
R
---
L
P
W
A
D
R
A
A
I
V
Q
G
Y
A
G
V
Y
S
S
F
L
L
H
A
E
R
A
A
E
R
Y
G
V
---------
P
A
H
E
I
L
Q
R
V
G
E
A
G
Y
V
G
G
Q
E
D
M
I
I
D
I
A
V
Q
L
A
E
E
---------
22
PsiBlast_CBE
83.39
62%
-89
- C2 -
4LRT
5
?
C:
[13-343]
-------
V
R
I
T
D
S
T
L
R
D
G
S
H
A
M
A
-
H
Q
F
T
E
E
Q
V
R
A
T
V
H
A
L
-
D
A
A
G
V
E
V
I
E
V
S
-------------
H
G
D
G
L
G
G
----
S
S
F
N
Y
G
F
S
A
V
D
E
I
D
L
V
A
A
A
V
D
E
A
------
V
------
N
A
K
I
A
V
L
L
L
P
----
G
V
G
T
-
V
R
D
-----
L
----
K
R
A
H
D
----
A
G
A
S
V
A
R
I
A
T
H
C
T
E
--------------
A
--------------
D
--------------
V
S
C
Q
H
F
A
A
A
R
E
L
G
M
E
T
V
G
F
L
--
M
L
A
------
H
---
R
I
G
P
E
E
L
A
R
Q
A
R
I
M
V
D
A
G
A
Q
C
V
Y
V
V
D
S
A
G
A
L
V
L
S
D
V
Q
A
R
V
Q
A
L
V
R
E
I
G
H
--
E
A
Q
V
G
F
H
G
H
Q
N
L
S
L
G
V
A
N
S
V
L
A
Y
Q
N
G
A
R
Q
I
D
------
G
A
L
C
A
L
G
A
------
G
A
G
N
S
P
T
E
I
L
A
A
T
F
E
R
----
L
N
I
E
T
G
V
N
V
Q
A
A
L
A
A
A
E
E
V
V
R
P
Y
L
---
P
R
---
L
P
W
A
D
R
A
A
I
V
Q
G
Y
A
G
V
Y
S
S
F
L
L
H
A
E
R
A
A
E
R
Y
G
V
---------
P
A
H
E
I
L
Q
R
V
G
E
A
G
Y
V
G
G
Q
E
D
M
I
I
D
I
A
V
Q
L
A
E
E
---------
3
PsiBlast_PDB
83.20
62%
-90
- C2 -
4LRT
3
?
A:
[13-343]
-------
V
R
I
T
D
S
T
L
R
D
G
S
H
A
M
A
-
H
Q
F
T
E
E
Q
V
R
A
T
V
H
A
L
-
D
A
A
G
V
E
V
I
E
V
S
-------------
H
G
D
G
L
G
G
----
S
S
F
N
Y
G
F
S
A
V
D
E
I
D
L
V
A
A
A
V
D
E
A
------
V
------
N
A
K
I
A
V
L
L
L
P
----
G
V
G
T
-
V
R
D
-----
L
----
K
R
A
H
D
----
A
G
A
S
V
A
R
I
A
T
H
C
T
E
--------------
A
--------------
D
--------------
V
S
C
Q
H
F
A
A
A
R
E
L
G
M
E
T
V
G
F
L
--
M
L
A
------
H
---
R
I
G
P
E
E
L
A
R
Q
A
R
I
M
V
D
A
G
A
Q
C
V
Y
V
V
D
S
A
G
A
L
V
L
S
D
V
Q
A
R
V
Q
A
L
V
R
E
I
G
H
--
E
A
Q
V
G
F
H
G
H
Q
N
L
S
L
G
V
A
N
S
V
L
A
Y
Q
N
G
A
R
Q
I
D
------
G
A
L
C
A
L
G
A
------
G
A
G
N
S
P
T
E
I
L
A
A
T
F
E
R
----
L
N
I
E
T
G
V
N
V
Q
A
A
L
A
A
A
E
E
V
V
R
P
Y
L
---
P
R
---
L
P
W
A
D
R
A
A
I
V
Q
G
Y
A
G
V
Y
S
S
F
L
L
H
A
E
R
A
A
E
R
Y
G
V
---------
P
A
H
E
I
L
Q
R
V
G
E
A
G
Y
V
G
G
Q
E
D
M
I
I
D
I
A
V
Q
L
A
E
E
---------
29
HHSearch
83.14
62%
-90
- C2 -
4LRT
3
?
A:
[10-343]
----
A
P
R
V
R
I
T
D
S
T
L
R
D
G
S
H
A
M
A
-
H
Q
F
T
E
E
Q
V
R
A
T
V
H
A
L
-
D
A
A
G
V
E
V
I
E
V
S
-------------
H
G
D
G
L
G
G
----
S
S
F
N
Y
G
F
S
A
V
D
E
I
D
L
V
A
A
A
V
D
E
A
------
V
------
N
A
K
I
A
V
L
L
L
P
----
G
V
G
T
-
V
R
D
-----
L
----
K
R
A
H
D
----
A
G
A
S
V
A
R
I
A
T
H
C
T
E
--------------
A
--------------
D
--------------
V
S
C
Q
H
F
A
A
A
R
E
L
G
M
E
T
V
G
F
L
--
M
L
A
------
H
---
R
I
G
P
E
E
L
A
R
Q
A
R
I
M
V
D
A
G
A
Q
C
V
Y
V
V
D
S
A
G
A
L
V
L
S
D
V
Q
A
R
V
Q
A
L
V
R
E
I
G
H
--
E
A
Q
V
G
F
H
G
H
Q
N
L
S
L
G
V
A
N
S
V
L
A
Y
Q
N
G
A
R
Q
I
D
------
G
A
L
C
A
L
G
A
------
G
A
G
N
S
P
T
E
I
L
A
A
T
F
E
R
----
L
N
I
E
T
G
V
N
V
Q
A
A
L
A
A
A
E
E
V
V
R
P
Y
L
---
P
R
---
L
P
W
A
D
R
A
A
I
V
Q
G
Y
A
G
V
Y
S
S
F
L
L
H
A
E
R
A
A
E
R
Y
G
V
---------
P
A
H
E
I
L
Q
R
V
G
E
A
G
Y
V
G
G
Q
E
D
M
I
I
D
I
A
V
Q
L
A
E
E
---------
28
HHSearch
81.10
48%
-88
- C2 -
1NVM
5
HOA_PSEUF
A:
[3-341]
-
F
N
P
S
K
K
L
Y
I
S
D
V
T
L
R
D
G
S
H
A
I
R
-
H
Q
Y
T
L
D
D
V
R
A
I
A
R
A
L
-
D
K
A
K
V
D
S
I
E
V
A
-------------
H
G
D
G
L
Q
G
----
S
S
F
N
Y
G
F
G
R
H
T
D
L
E
Y
I
E
A
V
A
G
E
I
------
S
------
H
A
Q
I
A
T
L
L
L
P
----
G
I
G
S
-
V
H
D
-----
L
----
K
N
A
Y
Q
----
A
G
A
R
V
V
R
V
A
T
H
C
T
E
--------------
A
--------------
D
--------------
V
S
K
Q
H
I
E
Y
A
R
N
L
G
M
D
T
V
G
F
L
--
M
M
S
------
H
---
M
I
P
A
E
K
L
A
E
Q
G
K
L
M
E
S
Y
G
A
T
C
I
Y
M
A
D
S
G
G
A
M
S
M
N
D
I
R
D
R
M
R
A
F
K
A
V
L
K
P
--
E
T
Q
V
G
M
H
A
H
H
N
L
S
L
G
V
A
N
S
I
V
A
V
E
E
G
C
D
R
V
D
------
A
S
L
A
G
M
G
A
------
G
A
G
N
A
P
L
E
V
F
I
A
V
A
E
R
----
L
G
W
N
H
G
T
D
L
Y
T
L
M
D
A
A
D
D
I
V
R
P
L
Q
---
D
R
---
P
V
R
V
D
R
E
T
L
G
L
G
Y
A
G
V
Y
S
S
F
L
R
H
A
E
I
A
A
A
K
Y
N
L
---------
K
T
L
D
I
L
V
E
L
G
H
R
R
M
V
G
G
Q
E
D
M
I
V
D
V
A
L
D
L
L
A
A
H
K
-------
51
Fugue
80.96
47%
-88
- C2 -
1NVM
5
HOA_PSEUF
A:
[2-341]
T
F
N
P
S
K
K
L
Y
I
S
D
V
T
L
R
D
G
S
H
A
I
R
-
H
Q
Y
T
L
D
D
V
R
A
I
A
R
A
L
-
D
K
A
K
V
D
S
I
E
V
A
-------------
H
G
D
G
L
Q
G
----
S
S
F
N
Y
G
F
G
R
H
T
D
L
E
Y
I
E
A
V
A
G
E
I
------
S
------
H
A
Q
I
A
T
L
L
L
P
----
G
I
G
S
-
V
H
D
-----
L
----
K
N
A
Y
Q
----
A
G
A
R
V
V
R
V
A
T
H
C
T
E
--------------
A
--------------
D
--------------
V
S
K
Q
H
I
E
Y
A
R
N
L
G
M
D
T
V
G
F
L
--
M
M
S
------
H
---
M
I
P
A
E
K
L
A
E
Q
G
K
L
M
E
S
Y
G
A
T
C
I
Y
M
A
D
S
G
G
A
M
S
M
N
D
I
R
D
R
M
R
A
F
K
A
V
L
K
P
--
E
T
Q
V
G
M
H
A
H
H
N
L
S
L
G
V
A
N
S
I
V
A
V
E
E
G
C
D
R
V
D
------
A
S
L
A
G
M
G
A
------
G
A
G
N
A
P
L
E
V
F
I
A
V
A
E
R
----
L
G
W
N
H
G
T
D
L
Y
T
L
M
D
A
A
D
D
I
V
R
P
L
Q
---
D
R
---
P
V
R
V
D
R
E
T
L
G
L
G
Y
A
G
V
Y
S
S
F
L
R
H
A
E
I
A
A
A
K
Y
N
L
---------
K
T
L
D
I
L
V
E
L
G
H
R
R
M
V
G
G
Q
E
D
M
I
V
D
V
A
L
D
L
L
A
A
H
K
-------
4
PsiBlast_PDB
80.42
49%
-88
- C2 -
1NVM
5
HOA_PSEUF
A:
[11-336]
---------
I
S
D
V
T
L
R
D
G
S
H
A
I
R
-
H
Q
Y
T
L
D
D
V
R
A
I
A
R
A
L
-
D
K
A
K
V
D
S
I
E
V
A
-------------
H
G
D
G
L
Q
G
----
S
S
F
N
Y
G
F
G
R
H
T
D
L
E
Y
I
E
A
V
A
G
E
I
------
S
------
H
A
Q
I
A
T
L
L
L
P
----
G
I
G
S
-
V
H
D
-----
L
----
K
N
A
Y
Q
----
A
G
A
R
V
V
R
V
A
T
H
C
T
E
--------------
A
--------------
D
--------------
V
S
K
Q
H
I
E
Y
A
R
N
L
G
M
D
T
V
G
F
L
--
M
M
S
------
H
---
M
I
P
A
E
K
L
A
E
Q
G
K
L
M
E
S
Y
G
A
T
C
I
Y
M
A
D
S
G
G
A
M
S
M
N
D
I
R
D
R
M
R
A
F
K
A
V
L
K
P
--
E
T
Q
V
G
M
H
A
H
H
N
L
S
L
G
V
A
N
S
I
V
A
V
E
E
G
C
D
R
V
D
------
A
S
L
A
G
M
G
A
------
G
A
G
N
A
P
L
E
V
F
I
A
V
A
E
R
----
L
G
W
N
H
G
T
D
L
Y
T
L
M
D
A
A
D
D
I
V
R
P
L
Q
---
D
R
---
P
V
R
V
D
R
E
T
L
G
L
G
Y
A
G
V
Y
S
S
F
L
R
H
A
E
I
A
A
A
K
Y
N
L
---------
K
T
L
D
I
L
V
E
L
G
H
R
R
M
V
G
G
Q
E
D
M
I
V
D
V
A
L
D
L
------------
25
PsiBlast_CBE
80.07
49%
-87
- C2 -
1NVM
15
HOA_PSEUF
C:
[11-336]
---------
I
S
D
V
T
L
R
D
G
S
H
A
I
R
-
H
Q
Y
T
L
D
D
V
R
A
I
A
R
A
L
-
D
K
A
K
V
D
S
I
E
V
A
-------------
H
G
D
G
L
Q
G
----
S
S
F
N
Y
G
F
G
R
H
T
D
L
E
Y
I
E
A
V
A
G
E
I
------
S
------
H
A
Q
I
A
T
L
L
L
P
----
G
I
G
S
-
V
H
D
-----
L
----
K
N
A
Y
Q
----
A
G
A
R
V
V
R
V
A
T
H
C
T
E
--------------
A
--------------
D
--------------
V
S
K
Q
H
I
E
Y
A
R
N
L
G
M
D
T
V
G
F
L
--
M
M
S
------
H
---
M
I
P
A
E
K
L
A
E
Q
G
K
L
M
E
S
Y
G
A
T
C
I
Y
M
A
D
S
G
G
A
M
S
M
N
D
I
R
D
R
M
R
A
F
K
A
V
L
K
P
--
E
T
Q
V
G
M
H
A
H
H
N
L
S
L
G
V
A
N
S
I
V
A
V
E
E
G
C
D
R
V
D
------
A
S
L
A
G
M
G
A
------
G
A
G
N
A
P
L
E
V
F
I
A
V
A
E
R
----
L
G
W
N
H
G
T
D
L
Y
T
L
M
D
A
A
D
D
I
V
R
P
L
Q
---
D
R
---
P
V
R
V
D
R
E
T
L
G
L
G
Y
A
G
V
Y
S
S
F
L
R
H
A
E
I
A
A
A
K
Y
N
L
---------
K
T
L
D
I
L
V
E
L
G
H
R
R
M
V
G
G
Q
E
D
M
I
V
D
V
A
L
D
L
------------
24
PsiBlast_CBE
79.62
49%
-88
- C2 -
1NVM
5
HOA_PSEUF
E:
[11-336]
---------
I
S
D
V
T
L
R
D
G
S
H
A
I
R
-
H
Q
Y
T
L
D
D
V
R
A
I
A
R
A
L
-
D
K
A
K
V
D
S
I
E
V
A
-------------
H
G
D
G
L
Q
G
----
S
S
F
N
Y
G
F
G
R
H
T
D
L
E
Y
I
E
A
V
A
G
E
I
------
S
------
H
A
Q
I
A
T
L
L
L
P
----
G
I
G
S
-
V
H
D
-----
L
----
K
N
A
Y
Q
----
A
G
A
R
V
V
R
V
A
T
H
C
T
E
--------------
A
--------------
D
--------------
V
S
K
Q
H
I
E
Y
A
R
N
L
G
M
D
T
V
G
F
L
--
M
M
S
------
H
---
M
I
P
A
E
K
L
A
E
Q
G
K
L
M
E
S
Y
G
A
T
C
I
Y
M
A
D
S
G
G
A
M
S
M
N
D
I
R
D
R
M
R
A
F
K
A
V
L
K
P
--
E
T
Q
V
G
M
H
A
H
H
N
L
S
L
G
V
A
N
S
I
V
A
V
E
E
G
C
D
R
V
D
------
A
S
L
A
G
M
G
A
------
G
A
G
N
A
P
L
E
V
F
I
A
V
A
E
R
----
L
G
W
N
H
G
T
D
L
Y
T
L
M
D
A
A
D
D
I
V
R
P
L
Q
---
D
R
---
P
V
R
V
D
R
E
T
L
G
L
G
Y
A
G
V
Y
S
S
F
L
R
H
A
E
I
A
A
A
K
Y
N
L
---------
K
T
L
D
I
L
V
E
L
G
H
R
R
M
V
G
G
Q
E
D
M
I
V
D
V
A
L
D
L
------------
23
PsiBlast_CBE
78.92
49%
-87
- C2 -
1NVM
5
HOA_PSEUF
G:
[11-336]
---------
I
S
D
V
T
L
R
D
G
S
H
A
I
R
-
H
Q
Y
T
L
D
D
V
R
A
I
A
R
A
L
-
D
K
A
K
V
D
S
I
E
V
A
-------------
H
G
D
G
L
Q
G
----
S
S
F
N
Y
G
F
G
R
H
T
D
L
E
Y
I
E
A
V
A
G
E
I
------
S
------
H
A
Q
I
A
T
L
L
L
P
----
G
I
G
S
-
V
H
D
-----
L
----
K
N
A
Y
Q
----
A
G
A
R
V
V
R
V
A
T
H
C
T
E
--------------
A
--------------
D
--------------
V
S
K
Q
H
I
E
Y
A
R
N
L
G
M
D
T
V
G
F
L
--
M
M
S
------
H
---
M
I
P
A
E
K
L
A
E
Q
G
K
L
M
E
S
Y
G
A
T
C
I
Y
M
A
D
S
G
G
A
M
S
M
N
D
I
R
D
R
M
R
A
F
K
A
V
L
K
P
--
E
T
Q
V
G
M
H
A
H
H
N
L
S
L
G
V
A
N
S
I
V
A
V
E
E
G
C
D
R
V
D
------
A
S
L
A
G
M
G
A
------
G
A
G
N
A
P
L
E
V
F
I
A
V
A
E
R
----
L
G
W
N
H
G
T
D
L
Y
T
L
M
D
A
A
D
D
I
V
R
P
L
Q
---
D
R
---
P
V
R
V
D
R
E
T
L
G
L
G
Y
A
G
V
Y
S
S
F
L
R
H
A
E
I
A
A
A
K
Y
N
L
---------
K
T
L
D
I
L
V
E
L
G
H
R
R
M
V
G
G
Q
E
D
M
I
V
D
V
A
L
D
L
------------
34
HHSearch
60.90
23%
-75
- C2 -
3RMJ
4
LEU1_NEIMB
A:
[10-329]
----
T
N
R
V
I
I
F
D
T
T
L
R
D
G
E
Q
S
P
G
-
A
A
M
T
K
E
E
K
I
R
V
A
R
Q
L
-
E
K
L
G
V
D
I
I
E
A
G
-------------
F
A
A
---------------
A
S
P
G
D
F
E
A
V
N
A
I
A
K
T
I
------
T
------
K
S
T
V
C
S
L
S
-------
R
A
I
-
E
R
D
-----
I
----
R
Q
A
G
E
A
V
AP
A
P
K
K
R
I
H
T
F
I
A
T
S
P
I
H
M
E
YKLKMK
P
K
Q
V
I
--------------
E
--------------
A
A
V
K
A
V
K
I
A
R
E
Y
T
D
D
V
E
F
S
C
--
E
D
A
------
L
---
R
S
E
I
D
F
L
A
E
I
C
G
A
V
I
E
A
G
A
T
T
I
N
I
P
D
T
V
G
Y
S
I
P
Y
K
T
E
E
F
F
R
E
L
I
A
K
T
P
N
GG
K
V
V
W
S
A
H
C
H
N
D
L
G
L
A
V
A
N
S
L
A
A
L
K
G
G
A
R
Q
V
E
------
C
T
V
N
G
L
G
E
------
R
A
G
N
A
S
V
E
E
I
V
M
A
L
K
V
R
HDL
F
G
L
E
T
G
I
D
T
T
Q
I
V
P
S
S
K
L
V
S
T
I
T
G
Y
P
V
Q
P
---
N
K
A
I
V
G
A
N
A
F
S
--------------
E
T
Y
E
I
M
-----------
S
A
E
S
V
G
W
----------------------------------
33
HHSearch
58.95
18%
-77
- C2 -
2NX9
1
?
A:
[4-360]
---
A
I
K
R
V
G
V
T
D
V
V
L
R
D
A
H
Q
S
L
F
A
T
R
L
R
I
D
D
M
L
P
I
A
Q
Q
L
-
D
Q
I
G
Y
W
S
L
E
C
W
-------------
G
G
A
T
-------
F
D
S
C
I
R
F
L
G
E
D
P
W
Q
R
L
R
L
L
K
Q
A
M
------
P
------
N
T
P
L
Q
M
L
L
R
G
QNLL
G
Y
R
H
Y
A
D
D
V
V
D
T
F
V
----
E
R
A
V
K
----
N
G
M
D
V
F
R
V
F
D
A
M
N
D
--------------
V
--------------
R
--------------
N
M
Q
Q
A
L
Q
A
V
K
K
M
G
A
H
A
Q
G
T
L
CY
T
T
S
------
P
---
V
H
N
L
Q
T
W
V
D
V
A
Q
Q
L
A
E
L
G
V
D
S
I
A
L
K
D
M
A
G
I
L
T
P
Y
A
A
E
E
L
V
S
T
L
K
K
Q
V
----
D
V
E
L
H
L
H
C
H
S
T
A
G
L
A
D
M
T
L
L
K
A
I
E
A
G
V
D
R
V
D
------
T
A
I
S
S
M
S
G
------
T
Y
G
H
P
A
T
E
S
L
V
A
T
L
Q
G
----
T
G
Y
D
T
G
L
D
I
A
K
L
E
Q
I
A
A
Y
F
R
D
V
R
K
---
K
Y
HAF
E
G
M
M
K
G
S
D
A
R
I
L
V
A
Q
V
P
G
G
M
L
T
N
M
E
S
Q
L
K
Q
Q
N
A
LDK
L
D
L
V
L
E
E
I
P
R
V
R
E
E
L
G
F
L
P
L
V
T
P
T
S
Q
I
V
G
T
Q
A
V
I
N
V
V
L
G
E
-------
35
HHSearch
57.38
22%
-79
- C2 -
3BLE
2
?
A:
[19-334]
------
R
L
E
I
L
D
V
T
L
R
D
G
E
Q
T
R
G
-
V
S
F
S
T
S
E
K
L
N
I
A
K
F
L
L
Q
K
L
N
V
D
R
V
E
I
A
-------------
S
A
R
V
---------------
S
K
G
E
L
E
T
V
Q
K
I
M
E
W
A
------
A
T
E
QLTE
R
I
E
I
L
G
F
V
D
--------
G
-
N
K
T
-----
V
----
D
W
I
K
D
----
S
G
A
K
V
L
N
L
L
T
K
G
S
L
H
H
L
E
K
Q
LGKT
P
K
E
F
F
--------------
T
--------------
D
V
S
F
V
I
E
Y
A
I
K
S
G
L
K
I
N
V
Y
L
--
E
D
W
------
S
N
G
F
R
N
S
P
D
Y
V
K
S
L
V
E
H
L
S
K
E
H
I
E
R
I
F
L
P
D
T
L
G
V
L
S
P
E
E
T
F
Q
G
V
D
S
L
I
Q
K
Y
-
P
--
D
I
H
F
E
F
H
G
H
N
D
Y
D
L
S
V
A
N
S
L
Q
A
I
R
A
G
V
K
G
L
H
------
A
S
I
N
G
L
G
E
------
R
A
G
N
T
P
L
E
A
L
V
T
T
I
H
D
K---
S
N
S
K
T
N
I
N
E
I
A
I
T
E
A
S
R
L
V
E
V
F
S
G
K
R
I
S
A
---
N
R
P
I
V
G
E
D
V
F
T
Q
------------
N
L
Y
A
N
P
--
I
---------
L
P
E
R
F
G
-----------------------------------
42
HHSearch
57.36
20%
-77
* C2 *
2FTP
3
LIUE_PSEAE
A:
[3-287]
-
M
N
L
P
K
K
V
R
L
V
E
V
G
P
R
D
G
L
Q
N
E
K
-
Q
P
I
E
V
A
D
K
I
R
L
V
D
D
L
-
S
A
A
G
L
D
Y
I
E
V
G
-------------
S
F
V
S
P
---------
K
W
V
P
Q
M
A
G
S
A
E
V
F
A
G
I
R
Q
R
-------
P
------
G
V
T
Y
A
A
L
A
P
--------
N
-
L
K
G
-----
F
----
E
A
A
L
E
----
S
G
V
K
E
V
A
V
F
A
A
A
S
E
--------------
A
F
S
Q
R
N
INCS
I
K
D
S
L
E
--------------
R
F
V
P
V
L
E
A
A
R
Q
H
Q
V
R
V
R
G
Y
I
--
S
C
V
LGCPYD
G
---
D
V
D
P
R
Q
V
A
W
V
A
R
E
L
Q
Q
M
G
C
Y
E
V
S
L
G
D
T
I
G
V
G
T
A
G
A
T
R
R
L
I
E
A
V
A
S
E
V
-
P
--
R
E
R
L
A
G
H
F
H
D
T
Y
G
Q
A
L
A
N
I
Y
A
S
L
L
E
G
I
A
V
F
D
------
S
S
V
A
G
L
G
G
CPYAKG
A
T
G
N
V
A
S
E
D
V
L
Y
L
L
N
G
----
L
E
I
H
T
G
V
D
M
H
A
L
V
D
A
G
Q
R
I
C
A
V
L
G
-------------------------------------------------------------------------------------------
47
HHSearch
57.32
21%
-81
- C2 -
1YDO
1
HMGCL_BACSU
A:
[1-284]
-
M
P
Y
P
K
K
V
T
I
K
E
V
G
P
R
D
G
L
Q
N
E
P
-
V
W
I
A
T
E
D
K
I
T
W
I
N
Q
L
-
S
R
T
G
L
S
Y
I
E
I
T
-------------
S
F
V
H
----------------
P
K
W
I
P
A
L
R
D
A
I
D
V
A
K
G
IDRE
K
------
G
V
T
Y
A
A
L
V
--------
P
N
-
Q
R
G
-----
L
----
E
N
A
L
E
----
G
G
I
N
E
A
C
V
F
M
S
A
S
E
--------------
T
--------------
H
N
R
K
N
INKS
T
S
E
S
L
H
I
L
K
Q
V
N
N
D
A
Q
K
A
N
L
T
T
R
A
Y
L
--
S
T
V
FGCPYE
K
---
D
V
P
I
E
Q
V
I
R
L
S
E
A
L
F
E
F
G
I
S
E
L
S
L
G
D
T
I
G
A
A
N
P
A
Q
V
E
T
V
L
E
A
L
L
A
R
F
-
P
--
A
N
Q
I
A
L
H
F
H
D
T
R
G
T
A
L
A
N
M
V
T
A
L
Q
M
G
I
T
V
F
D
------
G
S
A
G
G
L
G
G
CPYAPG
S
S
G
N
A
A
T
E
D
I
V
Y
M
L
E
Q
----
M
D
I
K
T
N
V
K
L
E
K
L
L
S
A
A
K
W
I
E
E
K
M
--------------------------------------------------------------------------------------------
15
PsiBlast_PDB
57.13
21%
-75
- C2 -
3MP5
-
HMGCL_HUMAN
A:
[6-281]
-------
V
K
I
V
E
V
G
P
M
D
G
L
Q
N
E
K
-
N
I
V
S
T
P
V
K
I
K
L
I
D
M
L
-
S
E
A
G
L
S
V
I
E
T
T
SFVSPKWVPQMGD
H
T
E
V
L
K
G
IQKF
P
G
I
N
Y
P
V
-
L
T
P
N
L
K
G
F
E
A
A
V
A
A
G
------
A
------
K
E
V
V
I
F
G
A
A
S
----
E
L
F
T
-
K
K
N
-----
I
NCS
I
E
E
S
F
Q
----
R
F
D
A
I
L
K
A
A
Q
---
S
--------------
A
--------------
N
--------------
I
S
V
R
G
Y
-
V
S
C
A
L
G
C
P
Y
E
G
-----------------
K
I
S
P
A
K
V
A
E
V
T
K
K
F
Y
S
M
G
C
Y
E
I
S
L
G
D
T
I
G
V
G
T
P
G
I
M
K
D
M
L
S
A
V
M
Q
E
V
-
P
--
L
A
A
L
A
V
H
C
H
D
T
Y
G
Q
A
L
A
N
T
L
M
A
L
Q
M
G
V
S
V
V
D
S
S
VAGL
G
G
C
P
Y
A
Q
G
------
A
S
G
N
L
A
T
E
D
L
V
Y
M
L
E
G
----
L
G
I
H
T
G
V
N
L
Q
K
L
L
E
A
G
N
F
I
C
Q
----------------------------------------------------------------------------------------------
11
PsiBlast_PDB
56.92
22%
-77
- C2 -
2CW6
2
HMGCL_HUMAN
A:
[6-281]
-------
V
K
I
V
E
V
G
P
R
D
G
L
Q
N
E
K
-
N
I
V
S
T
P
V
K
I
K
L
I
D
M
L
-
S
E
A
G
L
S
V
I
E
T
T
SFVSPKWVPQMGD
H
T
E
V
L
K
G
IQKF
P
G
I
N
Y
P
V
-
L
T
P
N
L
K
G
F
E
A
A
V
A
A
G
------
A
------
K
E
V
V
I
F
G
A
A
S
----
E
L
F
T
-
K
K
N
-----
I
NCS
I
E
E
S
F
Q
----
R
F
D
A
I
L
K
A
A
Q
---
S
--------------
A
--------------
N
--------------
I
S
V
R
G
Y
-
V
S
C
A
L
G
C
P
Y
E
G
-----------------
K
I
S
P
A
K
V
A
E
V
T
K
K
F
Y
S
M
G
C
Y
E
I
S
L
G
D
T
I
G
V
G
T
P
G
I
M
K
D
M
L
S
A
V
M
Q
E
V
-
P
--
L
A
A
L
A
V
H
C
H
D
T
Y
G
Q
A
L
A
N
T
L
M
A
L
Q
M
G
V
S
V
V
D
S
S
VAGL
G
G
C
P
Y
A
Q
G
------
A
S
G
N
L
A
T
E
D
L
V
Y
M
L
E
G
----
L
G
I
H
T
G
V
N
L
Q
K
L
L
E
A
G
N
F
I
C
Q
----------------------------------------------------------------------------------------------