@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3546: (2016-05-21 )
MGYPVIVEATRSPIGKRNGWLSGLHATELLGAVQKAVVDKAGIQSGLHAGDVEQVIGGCVTQFGEQSNNISRVAWLTAGLPEHVGATTVDCQCGSGQQANHLIAGLIAAGAIDVGIACGIEAMSRVGLGANAGPDRSLIRAQSWDIDLPNQFEAAERIAKRRGITREDVDVFGLESQRRAQRAWAEGRFDREISPIQAPVLDEQNQPTGERRLVFRDQGLRETTMAGLGELKPVLEGGIHTAGTSSQISDGAAAVLWMDEAVARAHGLTPRARIVAQALVGAEPYYHLDGPVQSTAKVLEKAGMKIGDIDIVEINEAFASVVLSWARVHEPDMDRVNVNGGAIALGHPVGCTGSRLITTALHELERTDQSLALITMCAGGALSTGTIIERI
Atome Classification :
(21 SA)
.........10......-..20........30........40-........50........60........70........80........90........100.......110.......120..---.....130---------..---......140..--.--....150.---......160.......170.......180.......190.......200.......210.......220-.......230....--.-..240.......250.......260.......270.......280.......290.......300.......310.......320.......330---.......340.......350.......360.......370.......380.......390
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MGY
P
V
I
V
E
ATRSPIGKR-NGWLS
G
L
H
A
T
E
L
L
G
A
V
Q
K
A
V
V
D
K
A
-
G
I
QSGLHAG
D
V
E
Q
V
I
G
G
C
V
T
Q
FGEQSNNI
S
R
V
A
W
L
TAGLPEHVGA
T
T
V
D
C
QCGSGQ
Q
A
N
H
L
I
A
G
L
I
A
A
G
A
I
D
V
G
I
A
C
G
I
E
A
M
S
---
R
VGLGAN----------AG---PDRS
L
I
R
AQSW--D--IDLP
N
Q
F
E
---
A
A
E
R
I
A
K
RRGI
T
R
E
D
V
D
VFG
L
E
S
Q
R
R
A
Q
R
A
W
AEGRFDREISPIQAPVLDEQNQPTGE
R
R
L
V
F
RDQGL
R
E
-
T
T
M
A
G
L
G
E
L
K
P
V
L
E--G-GIHTAGTSSQISDG
A
A
A
V
L
W
M
D
E
A
V
A
R
AHGL
T
P
R
A
R
I
V
A
Q
A
L
VGAE
P
Y
Y
HLDG
P
V
Q
S
T
A
K
V
L
E
K
AGMKIG
D
I
D
I
V
E
I
N
E
A
F
A
S
V
V
L
S
W
A
RVHEPD---M
D
R
V
NVNG
G
A
I
A
LGHPVGCT
G
S
R
L
I
T
T
A
L
H
E
L
E
RTDQ
S
L
A
L
I
T
M
CAGGALST
G
T
I
IERI
2
PsiBlast_PDB
98.99
99%
-86
- C7 -
4UBT
-
?
A:
[1-391]
M
G
Y
P
V
I
V
E
A
T
R
S
P
I
G
K
R
-
N
G
W
L
S
G
L
H
A
T
E
L
L
G
A
V
Q
K
A
V
V
D
K
A
-
G
I
Q
S
G
L
H
A
G
D
V
E
Q
V
I
G
G
C
V
T
Q
F
G
E
Q
S
N
N
I
S
R
V
A
W
L
T
A
G
L
P
E
H
V
G
A
T
T
V
D
C
Q
S
G
S
G
Q
Q
A
N
H
L
I
A
G
L
I
A
A
G
A
I
D
V
G
I
A
C
G
I
E
A
M
S
---
R
V
G
L
G
A
N
----------
A
G
---
P
D
R
S
L
I
R
A
Q
S
W
--
D
--
I
D
L
P
N
Q
F
E
---
A
A
E
R
I
A
K
R
R
G
I
T
R
E
D
V
D
V
F
G
L
E
S
Q
R
R
A
Q
R
A
W
A
E
G
R
F
D
R
E
I
S
P
I
Q
A
P
V
L
D
E
Q
N
Q
P
T
G
E
R
R
L
V
F
R
D
Q
G
L
R
E
-
T
T
M
A
G
L
G
E
L
K
P
V
L
E
--
G
-
G
I
H
T
A
G
T
S
S
Q
I
S
D
G
A
A
A
V
L
W
M
D
E
A
V
A
R
A
H
G
L
T
P
R
A
R
I
V
A
Q
A
L
V
G
A
E
P
Y
Y
H
L
D
G
P
V
Q
S
T
A
K
V
L
E
K
A
G
M
K
I
G
D
I
D
I
V
E
I
N
E
A
F
A
S
V
V
L
S
W
A
R
V
H
E
P
D
---
M
D
R
V
N
V
N
G
G
A
I
A
L
G
H
P
V
G
C
T
G
S
R
L
I
T
T
A
L
H
E
L
E
R
T
D
Q
S
L
A
L
I
T
M
C
A
G
G
A
L
S
T
G
T
I
I
E
R
I
22
PsiBlast_CBE
98.39
100%
-83
- C7 -
4UBV
14
?
B:
[9-399]
M
G
Y
P
V
I
V
E
A
T
R
S
P
I
G
K
R
-
N
G
W
L
S
G
L
H
A
T
E
L
L
G
A
V
Q
K
A
V
V
D
K
A
-
G
I
Q
S
G
L
H
A
G
D
V
E
Q
V
I
G
G
C
V
T
Q
F
G
E
Q
S
N
N
I
S
R
V
A
W
L
T
A
G
L
P
E
H
V
G
A
T
T
V
D
C
Q
-
G
S
G
Q
Q
A
N
H
L
I
A
G
L
I
A
A
G
A
I
D
V
G
I
A
C
G
I
E
A
M
S
---
R
V
G
L
G
A
N
----------
A
G
---
P
D
R
S
L
I
R
A
Q
S
W
--
D
--
I
D
L
P
N
Q
F
E
---
A
A
E
R
I
A
K
R
R
G
I
T
R
E
D
V
D
V
F
G
L
E
S
Q
R
R
A
Q
R
A
W
A
E
G
R
F
D
R
E
I
S
P
I
Q
A
P
V
L
D
E
Q
N
Q
P
T
G
E
R
R
L
V
F
R
D
Q
G
L
R
E
-
T
T
M
A
G
L
G
E
L
K
P
V
L
E
--
G
-
G
I
H
T
A
G
T
S
S
Q
I
S
D
G
A
A
A
V
L
W
M
D
E
A
V
A
R
A
H
G
L
T
P
R
A
R
I
V
A
Q
A
L
V
G
A
E
P
Y
Y
H
L
D
G
P
V
Q
S
T
A
K
V
L
E
K
A
G
M
K
I
G
D
I
D
I
V
E
I
N
E
A
F
A
S
V
V
L
S
W
A
R
V
H
E
P
D
---
M
D
R
V
N
V
N
G
G
A
I
A
L
G
H
P
V
G
C
T
G
S
R
L
I
T
T
A
L
H
E
L
E
R
T
D
Q
S
L
A
L
I
T
M
C
A
G
G
A
L
S
T
G
T
I
I
E
R
I
103
HHSearch
98.30
98%
-85
- C7 -
4UBT
-
?
A:
[1-390]
M
G
Y
P
V
I
V
E
A
T
R
S
P
I
G
K
R
-
N
G
W
L
S
G
L
H
A
T
E
L
L
G
A
V
Q
K
A
V
V
D
K
A
-
G
I
Q
S
G
L
H
A
G
D
V
E
Q
V
I
G
G
C
V
T
Q
F
G
E
Q
S
N
N
I
S
R
V
A
W
L
T
A
G
L
P
E
H
V
G
A
T
T
V
D
C
Q
S
G
S
G
Q
Q
A
N
H
L
I
A
G
L
I
A
A
G
A
I
D
V
G
I
A
C
G
I
E
A
M
S
---
R
V
G
L
G
A
N
----------
A
G
---
P
----
D
R
S
L
I
R
AQ
S
WD
I
D
L
P
N
Q
F
E
---
A
A
E
R
I
A
K
R
R
G
I
T
R
E
D
V
D
V
F
G
L
E
S
Q
R
R
A
Q
R
A
W
A
E
G
R
F
D
R
E
I
S
P
I
Q
A
P
V
L
D
E
Q
N
Q
P
T
G
E
R
R
L
V
F
R
D
Q
G
L
R
E
-
T
T
M
A
G
L
G
E
L
K
P
V
L
E
--
G
-
G
I
H
T
A
G
T
S
S
Q
I
S
D
G
A
A
A
V
L
W
M
D
E
A
V
A
R
A
H
G
L
T
P
R
A
R
I
V
A
Q
A
L
V
G
A
E
P
Y
Y
H
L
D
G
P
V
Q
S
T
A
K
V
L
E
K
A
G
M
K
I
G
D
I
D
I
V
E
I
N
E
A
F
A
S
V
V
L
S
W
A
R
V
H
E
P
D
---
M
D
R
V
N
V
N
G
G
A
I
A
L
G
H
P
V
G
C
T
G
S
R
L
I
T
T
A
L
H
E
L
E
R
T
D
Q
S
L
A
L
I
T
M
C
A
G
G
A
L
S
T
G
T
I
I
E
R
-
23
PsiBlast_CBE
98.24
100%
-84
- C7 -
4UBV
9
?
A:
[9-399]
M
G
Y
P
V
I
V
E
A
T
R
S
P
I
G
K
R
-
N
G
W
L
S
G
L
H
A
T
E
L
L
G
A
V
Q
K
A
V
V
D
K
A
-
G
I
Q
S
G
L
H
A
G
D
V
E
Q
V
I
G
G
C
V
T
Q
F
G
E
Q
S
N
N
I
S
R
V
A
W
L
T
A
G
L
P
E
H
V
G
A
T
T
V
D
C
Q
-
G
S
G
Q
Q
A
N
H
L
I
A
G
L
I
A
A
G
A
I
D
V
G
I
A
C
G
I
E
A
M
S
---
R
V
G
L
G
A
N
----------
A
G
---
P
D
R
S
L
I
R
A
Q
S
W
--
D
--
I
D
L
P
N
Q
F
E
---
A
A
E
R
I
A
K
R
R
G
I
T
R
E
D
V
D
V
F
G
L
E
S
Q
R
R
A
Q
R
A
W
A
E
G
R
F
D
R
E
I
S
P
I
Q
A
P
V
L
D
E
Q
N
Q
P
T
G
E
R
R
L
V
F
R
D
Q
G
L
R
E
-
T
T
M
A
G
L
G
E
L
K
P
V
L
E
--
G
-
G
I
H
T
A
G
T
S
S
Q
I
S
D
G
A
A
A
V
L
W
M
D
E
A
V
A
R
A
H
G
L
T
P
R
A
R
I
V
A
Q
A
L
V
G
A
E
P
Y
Y
H
L
D
G
P
V
Q
S
T
A
K
V
L
E
K
A
G
M
K
I
G
D
I
D
I
V
E
I
N
E
A
F
A
S
V
V
L
S
W
A
R
V
H
E
P
D
---
M
D
R
V
N
V
N
G
G
A
I
A
L
G
H
P
V
G
C
T
G
S
R
L
I
T
T
A
L
H
E
L
E
R
T
D
Q
S
L
A
L
I
T
M
C
A
G
G
A
L
S
T
G
T
I
I
E
R
I
21
PsiBlast_CBE
97.25
100%
-86
- C7 -
4UBW
6
?
B:
[9-399]
M
G
Y
P
V
I
V
E
A
T
R
S
P
I
G
K
R
-
N
G
W
L
S
G
L
H
A
T
E
L
L
G
A
V
Q
K
A
V
V
D
K
A
-
G
I
Q
S
G
L
H
A
G
D
V
E
Q
V
I
G
G
C
V
T
Q
F
G
E
Q
S
N
N
I
S
R
V
A
W
L
T
A
G
L
P
E
H
V
G
A
T
T
V
D
C
Q
C
G
S
G
Q
Q
A
N
H
L
I
A
G
L
I
A
A
G
A
I
D
V
G
I
A
C
G
I
E
A
M
S
---
R
V
G
L
G
A
N
----------
A
G
---
P
D
R
S
L
I
R
A
Q
S
W
--
D
--
I
D
L
P
N
Q
F
E
---
A
A
E
R
I
A
K
R
R
G
I
T
R
E
D
V
D
V
F
G
L
E
S
Q
R
R
A
Q
R
A
W
A
E
G
R
F
D
R
E
I
S
P
I
Q
A
P
V
L
D
E
Q
N
Q
P
T
G
E
R
R
L
V
F
R
D
Q
G
L
R
E
-
T
T
M
A
G
L
G
E
L
K
P
V
L
E
--
G
-
G
I
H
T
A
G
T
S
S
Q
I
S
D
G
A
A
A
V
L
W
M
D
E
A
V
A
R
A
H
G
L
T
P
R
A
R
I
V
A
Q
A
L
V
G
A
E
P
Y
Y
H
L
D
G
P
V
Q
S
T
A
K
V
L
E
K
A
G
M
K
I
G
D
I
D
I
V
E
I
N
E
A
F
A
S
V
V
L
S
W
A
R
V
H
E
P
D
---
M
D
R
V
N
V
N
G
G
A
I
A
L
G
H
P
V
G
C
T
G
S
R
L
I
T
T
A
L
H
E
L
E
R
T
D
Q
S
L
A
L
I
T
M
C
A
G
G
A
L
S
T
G
T
I
I
E
R
I
24
PsiBlast_CBE
96.95
99%
-85
- C7 -
4UBU
2
?
H:
[1-391]
M
G
Y
P
V
I
V
E
A
T
R
S
P
I
G
K
R
-
N
G
W
L
S
G
L
H
A
T
E
L
L
G
A
V
Q
K
A
V
V
D
K
A
-
G
I
Q
S
G
L
H
A
G
D
V
E
Q
V
I
G
G
C
V
T
Q
F
G
E
Q
S
N
N
I
S
R
V
A
W
L
T
A
G
L
P
E
H
V
G
A
T
T
V
D
C
Q
-
G
S
G
Q
Q
A
N
H
L
I
A
G
L
I
A
A
G
A
I
D
V
G
I
A
C
G
I
E
A
M
S
---
R
V
G
L
G
A
N
----------
A
G
---
P
D
R
S
L
I
R
A
Q
S
W
--
D
--
I
D
L
P
N
Q
F
E
---
A
A
E
R
I
A
K
R
R
G
I
T
R
E
D
V
D
V
F
G
L
E
S
Q
R
R
A
Q
R
A
W
A
E
G
R
F
D
R
E
I
S
P
I
Q
A
P
V
L
D
E
Q
N
Q
P
T
G
E
R
R
L
V
F
R
D
Q
G
L
R
E
-
T
T
M
A
G
L
G
E
L
K
P
V
L
E
--
G
-
G
I
H
T
A
G
T
S
S
Q
I
S
D
G
A
A
A
V
L
W
M
D
E
A
V
A
R
A
H
G
L
T
P
R
A
R
I
V
A
Q
A
L
V
G
A
E
P
Y
Y
H
L
D
G
P
V
Q
S
T
A
K
V
L
E
K
A
G
M
K
I
G
D
I
D
I
V
E
I
N
E
A
F
A
S
V
V
L
S
W
A
R
V
H
E
P
D
---
M
D
R
V
N
V
N
G
G
A
I
A
L
G
H
P
V
G
C
T
G
S
R
L
I
T
T
A
L
H
E
L
E
R
T
D
Q
S
L
A
L
I
T
M
C
A
G
G
A
L
S
T
G
T
I
I
E
R
I
27
PsiBlast_CBE
96.74
99%
-83
- C7 -
4UBU
2
?
E:
[1-391]
M
G
Y
P
V
I
V
E
A
T
R
S
P
I
G
K
R
-
N
G
W
L
S
G
L
H
A
T
E
L
L
G
A
V
Q
K
A
V
V
D
K
A
-
G
I
Q
S
G
L
H
A
G
D
V
E
Q
V
I
G
G
C
V
T
Q
F
G
E
Q
S
N
N
I
S
R
V
A
W
L
T
A
G
L
P
E
H
V
G
A
T
T
V
D
C
Q
-
G
S
G
Q
Q
A
N
H
L
I
A
G
L
I
A
A
G
A
I
D
V
G
I
A
C
G
I
E
A
M
S
---
R
V
G
L
G
A
N
----------
A
G
---
P
D
R
S
L
I
R
A
Q
S
W
--
D
--
I
D
L
P
N
Q
F
E
---
A
A
E
R
I
A
K
R
R
G
I
T
R
E
D
V
D
V
F
G
L
E
S
Q
R
R
A
Q
R
A
W
A
E
G
R
F
D
R
E
I
S
P
I
Q
A
P
V
L
D
E
Q
N
Q
P
T
G
E
R
R
L
V
F
R
D
Q
G
L
R
E
-
T
T
M
A
G
L
G
E
L
K
P
V
L
E
--
G
-
G
I
H
T
A
G
T
S
S
Q
I
S
D
G
A
A
A
V
L
W
M
D
E
A
V
A
R
A
H
G
L
T
P
R
A
R
I
V
A
Q
A
L
V
G
A
E
P
Y
Y
H
L
D
G
P
V
Q
S
T
A
K
V
L
E
K
A
G
M
K
I
G
D
I
D
I
V
E
I
N
E
A
F
A
S
V
V
L
S
W
A
R
V
H
E
P
D
---
M
D
R
V
N
V
N
G
G
A
I
A
L
G
H
P
V
G
C
T
G
S
R
L
I
T
T
A
L
H
E
L
E
R
T
D
Q
S
L
A
L
I
T
M
C
A
G
G
A
L
S
T
G
T
I
I
E
R
I
1
PsiBlast_PDB
96.67
100%
-84
- C7 -
4UBW
21
?
A:
[9-399]
M
G
Y
P
V
I
V
E
A
T
R
S
P
I
G
K
R
-
N
G
W
L
S
G
L
H
A
T
E
L
L
G
A
V
Q
K
A
V
V
D
K
A
-
G
I
Q
S
G
L
H
A
G
D
V
E
Q
V
I
G
G
C
V
T
Q
F
G
E
Q
S
N
N
I
S
R
V
A
W
L
T
A
G
L
P
E
H
V
G
A
T
T
V
D
C
Q
C
G
S
G
Q
Q
A
N
H
L
I
A
G
L
I
A
A
G
A
I
D
V
G
I
A
C
G
I
E
A
M
S
---
R
V
G
L
G
A
N
----------
A
G
---
P
D
R
------
S
W
--
D
--
I
D
L
P
N
Q
F
E
---
A
A
E
R
I
A
K
R
R
G
I
T
R
E
D
V
D
V
F
G
L
E
S
Q
R
R
A
Q
R
A
W
A
E
G
R
F
D
R
E
I
S
P
I
Q
A
P
V
L
D
E
Q
N
Q
P
T
G
E
R
R
L
V
F
R
D
Q
G
L
R
E
-
T
T
M
A
G
L
G
E
L
K
P
V
L
E
--
G
-
G
I
H
T
A
G
T
S
S
Q
I
S
D
G
A
A
A
V
L
W
M
D
E
A
V
A
R
A
H
G
L
T
P
R
A
R
I
V
A
Q
A
L
V
G
A
E
P
Y
Y
H
L
D
G
P
V
Q
S
T
A
K
V
L
E
K
A
G
M
K
I
G
D
I
D
I
V
E
I
N
E
A
F
A
S
V
V
L
S
W
A
R
V
H
E
P
D
---
M
D
R
V
N
V
N
G
G
A
I
A
L
G
H
P
V
G
C
T
G
S
R
L
I
T
T
A
L
H
E
L
E
R
T
D
Q
S
L
A
L
I
T
M
C
A
G
G
A
L
S
T
G
T
I
I
E
R
I
30
PsiBlast_CBE
96.63
99%
-84
- C7 -
4UBU
1
?
B:
[1-391]
M
G
Y
P
V
I
V
E
A
T
R
S
P
I
G
K
R
-
N
G
W
L
S
G
L
H
A
T
E
L
L
G
A
V
Q
K
A
V
V
D
K
A
-
G
I
Q
S
G
L
H
A
G
D
V
E
Q
V
I
G
G
C
V
T
Q
F
G
E
Q
S
N
N
I
S
R
V
A
W
L
T
A
G
L
P
E
H
V
G
A
T
T
V
D
C
Q
-
G
S
G
Q
Q
A
N
H
L
I
A
G
L
I
A
A
G
A
I
D
V
G
I
A
C
G
I
E
A
M
S
---
R
V
G
L
G
A
N
----------
A
G
---
P
D
R
S
L
I
R
A
Q
S
W
--
D
--
I
D
L
P
N
Q
F
E
---
A
A
E
R
I
A
K
R
R
G
I
T
R
E
D
V
D
V
F
G
L
E
S
Q
R
R
A
Q
R
A
W
A
E
G
R
F
D
R
E
I
S
P
I
Q
A
P
V
L
D
E
Q
N
Q
P
T
G
E
R
R
L
V
F
R
D
Q
G
L
R
E
-
T
T
M
A
G
L
G
E
L
K
P
V
L
E
--
G
-
G
I
H
T
A
G
T
S
S
Q
I
S
D
G
A
A
A
V
L
W
M
D
E
A
V
A
R
A
H
G
L
T
P
R
A
R
I
V
A
Q
A
L
V
G
A
E
P
Y
Y
H
L
D
G
P
V
Q
S
T
A
K
V
L
E
K
A
G
M
K
I
G
D
I
D
I
V
E
I
N
E
A
F
A
S
V
V
L
S
W
A
R
V
H
E
P
D
---
M
D
R
V
N
V
N
G
G
A
I
A
L
G
H
P
V
G
C
T
G
S
R
L
I
T
T
A
L
H
E
L
E
R
T
D
Q
S
L
A
L
I
T
M
C
A
G
G
A
L
S
T
G
T
I
I
E
R
I
26
PsiBlast_CBE
96.43
99%
-84
- C7 -
4UBU
1
?
F:
[1-391]
M
G
Y
P
V
I
V
E
A
T
R
S
P
I
G
K
R
-
N
G
W
L
S
G
L
H
A
T
E
L
L
G
A
V
Q
K
A
V
V
D
K
A
-
G
I
Q
S
G
L
H
A
G
D
V
E
Q
V
I
G
G
C
V
T
Q
F
G
E
Q
S
N
N
I
S
R
V
A
W
L
T
A
G
L
P
E
H
V
G
A
T
T
V
D
C
Q
-
G
S
G
Q
Q
A
N
H
L
I
A
G
L
I
A
A
G
A
I
D
V
G
I
A
C
G
I
E
A
M
S
---
R
V
G
L
G
A
N
----------
A
G
---
P
D
R
S
L
I
R
A
Q
S
W
--
D
--
I
D
L
P
N
Q
F
E
---
A
A
E
R
I
A
K
R
R
G
I
T
R
E
D
V
D
V
F
G
L
E
S
Q
R
R
A
Q
R
A
W
A
E
G
R
F
D
R
E
I
S
P
I
Q
A
P
V
L
D
E
Q
N
Q
P
T
G
E
R
R
L
V
F
R
D
Q
G
L
R
E
-
T
T
M
A
G
L
G
E
L
K
P
V
L
E
--
G
-
G
I
H
T
A
G
T
S
S
Q
I
S
D
G
A
A
A
V
L
W
M
D
E
A
V
A
R
A
H
G
L
T
P
R
A
R
I
V
A
Q
A
L
V
G
A
E
P
Y
Y
H
L
D
G
P
V
Q
S
T
A
K
V
L
E
K
A
G
M
K
I
G
D
I
D
I
V
E
I
N
E
A
F
A
S
V
V
L
S
W
A
R
V
H
E
P
D
---
M
D
R
V
N
V
N
G
G
A
I
A
L
G
H
P
V
G
C
T
G
S
R
L
I
T
T
A
L
H
E
L
E
R
T
D
Q
S
L
A
L
I
T
M
C
A
G
G
A
L
S
T
G
T
I
I
E
R
I
3
PsiBlast_PDB
96.30
99%
-83
- C7 -
4UBU
2
?
A:
[1-391]
M
G
Y
P
V
I
V
E
A
T
R
S
P
I
G
K
R
-
N
G
W
L
S
G
L
H
A
T
E
L
L
G
A
V
Q
K
A
V
V
D
K
A
-
G
I
Q
S
G
L
H
A
G
D
V
E
Q
V
I
G
G
C
V
T
Q
F
G
E
Q
S
N
N
I
S
R
V
A
W
L
T
A
G
L
P
E
H
V
G
A
T
T
V
D
C
Q
-
G
S
G
Q
Q
A
N
H
L
I
A
G
L
I
A
A
G
A
I
D
V
G
I
A
C
G
I
E
A
M
S
---
R
V
G
L
G
A
N
----------
A
G
---
P
D
R
S
L
I
R
A
Q
S
W
--
D
--
I
D
L
P
N
Q
F
E
---
A
A
E
R
I
A
K
R
R
G
I
T
R
E
D
V
D
V
F
G
L
E
S
Q
R
R
A
Q
R
A
W
A
E
G
R
F
D
R
E
I
S
P
I
Q
A
P
V
L
D
E
Q
N
Q
P
T
G
E
R
R
L
V
F
R
D
Q
G
L
R
E
-
T
T
M
A
G
L
G
E
L
K
P
V
L
E
--
G
-
G
I
H
T
A
G
T
S
S
Q
I
S
D
G
A
A
A
V
L
W
M
D
E
A
V
A
R
A
H
G
L
T
P
R
A
R
I
V
A
Q
A
L
V
G
A
E
P
Y
Y
H
L
D
G
P
V
Q
S
T
A
K
V
L
E
K
A
G
M
K
I
G
D
I
D
I
V
E
I
N
E
A
F
A
S
V
V
L
S
W
A
R
V
H
E
P
D
---
M
D
R
V
N
V
N
G
G
A
I
A
L
G
H
P
V
G
C
T
G
S
R
L
I
T
T
A
L
H
E
L
E
R
T
D
Q
S
L
A
L
I
T
M
C
A
G
G
A
L
S
T
G
T
I
I
E
R
I
25
PsiBlast_CBE
96.21
99%
-83
- C7 -
4UBU
3
?
G:
[1-391]
M
G
Y
P
V
I
V
E
A
T
R
S
P
I
G
K
R
-
N
G
W
L
S
G
L
H
A
T
E
L
L
G
A
V
Q
K
A
V
V
D
K
A
-
G
I
Q
S
G
L
H
A
G
D
V
E
Q
V
I
G
G
C
V
T
Q
F
G
E
Q
S
N
N
I
S
R
V
A
W
L
T
A
G
L
P
E
H
V
G
A
T
T
V
D
C
Q
-
G
S
G
Q
Q
A
N
H
L
I
A
G
L
I
A
A
G
A
I
D
V
G
I
A
C
G
I
E
A
M
S
---
R
V
G
L
G
A
N
----------
A
G
---
P
D
R
S
L
I
R
A
Q
S
W
--
D
--
I
D
L
P
N
Q
F
E
---
A
A
E
R
I
A
K
R
R
G
I
T
R
E
D
V
D
V
F
G
L
E
S
Q
R
R
A
Q
R
A
W
A
E
G
R
F
D
R
E
I
S
P
I
Q
A
P
V
L
D
E
Q
N
Q
P
T
G
E
R
R
L
V
F
R
D
Q
G
L
R
E
-
T
T
M
A
G
L
G
E
L
K
P
V
L
E
--
G
-
G
I
H
T
A
G
T
S
S
Q
I
S
D
G
A
A
A
V
L
W
M
D
E
A
V
A
R
A
H
G
L
T
P
R
A
R
I
V
A
Q
A
L
V
G
A
E
P
Y
Y
H
L
D
G
P
V
Q
S
T
A
K
V
L
E
K
A
G
M
K
I
G
D
I
D
I
V
E
I
N
E
A
F
A
S
V
V
L
S
W
A
R
V
H
E
P
D
---
M
D
R
V
N
V
N
G
G
A
I
A
L
G
H
P
V
G
C
T
G
S
R
L
I
T
T
A
L
H
E
L
E
R
T
D
Q
S
L
A
L
I
T
M
C
A
G
G
A
L
S
T
G
T
I
I
E
R
I
28
PsiBlast_CBE
96.20
99%
-83
- C7 -
4UBU
1
?
D:
[1-391]
M
G
Y
P
V
I
V
E
A
T
R
S
P
I
G
K
R
-
N
G
W
L
S
G
L
H
A
T
E
L
L
G
A
V
Q
K
A
V
V
D
K
A
-
G
I
Q
S
G
L
H
A
G
D
V
E
Q
V
I
G
G
C
V
T
Q
F
G
E
Q
S
N
N
I
S
R
V
A
W
L
T
A
G
L
P
E
H
V
G
A
T
T
V
D
C
Q
-
G
S
G
Q
Q
A
N
H
L
I
A
G
L
I
A
A
G
A
I
D
V
G
I
A
C
G
I
E
A
M
S
---
R
V
G
L
G
A
N
----------
A
G
---
P
D
R
S
L
I
R
A
Q
S
W
--
D
--
I
D
L
P
N
Q
F
E
---
A
A
E
R
I
A
K
R
R
G
I
T
R
E
D
V
D
V
F
G
L
E
S
Q
R
R
A
Q
R
A
W
A
E
G
R
F
D
R
E
I
S
P
I
Q
A
P
V
L
D
E
Q
N
Q
P
T
G
E
R
R
L
V
F
R
D
Q
G
L
R
E
-
T
T
M
A
G
L
G
E
L
K
P
V
L
E
--
G
-
G
I
H
T
A
G
T
S
S
Q
I
S
D
G
A
A
A
V
L
W
M
D
E
A
V
A
R
A
H
G
L
T
P
R
A
R
I
V
A
Q
A
L
V
G
A
E
P
Y
Y
H
L
D
G
P
V
Q
S
T
A
K
V
L
E
K
A
G
M
K
I
G
D
I
D
I
V
E
I
N
E
A
F
A
S
V
V
L
S
W
A
R
V
H
E
P
D
---
M
D
R
V
N
V
N
G
G
A
I
A
L
G
H
P
V
G
C
T
G
S
R
L
I
T
T
A
L
H
E
L
E
R
T
D
Q
S
L
A
L
I
T
M
C
A
G
G
A
L
S
T
G
T
I
I
E
R
I
29
PsiBlast_CBE
96.12
99%
-83
- C7 -
4UBU
1
?
C:
[1-391]
M
G
Y
P
V
I
V
E
A
T
R
S
P
I
G
K
R
-
N
G
W
L
S
G
L
H
A
T
E
L
L
G
A
V
Q
K
A
V
V
D
K
A
-
G
I
Q
S
G
L
H
A
G
D
V
E
Q
V
I
G
G
C
V
T
Q
F
G
E
Q
S
N
N
I
S
R
V
A
W
L
T
A
G
L
P
E
H
V
G
A
T
T
V
D
C
Q
-
G
S
G
Q
Q
A
N
H
L
I
A
G
L
I
A
A
G
A
I
D
V
G
I
A
C
G
I
E
A
M
S
---
R
V
G
L
G
A
N
----------
A
G
---
P
D
R
S
L
I
R
A
Q
S
W
--
D
--
I
D
L
P
N
Q
F
E
---
A
A
E
R
I
A
K
R
R
G
I
T
R
E
D
V
D
V
F
G
L
E
S
Q
R
R
A
Q
R
A
W
A
E
G
R
F
D
R
E
I
S
P
I
Q
A
P
V
L
D
E
Q
N
Q
P
T
G
E
R
R
L
V
F
R
D
Q
G
L
R
E
-
T
T
M
A
G
L
G
E
L
K
P
V
L
E
--
G
-
G
I
H
T
A
G
T
S
S
Q
I
S
D
G
A
A
A
V
L
W
M
D
E
A
V
A
R
A
H
G
L
T
P
R
A
R
I
V
A
Q
A
L
V
G
A
E
P
Y
Y
H
L
D
G
P
V
Q
S
T
A
K
V
L
E
K
A
G
M
K
I
G
D
I
D
I
V
E
I
N
E
A
F
A
S
V
V
L
S
W
A
R
V
H
E
P
D
---
M
D
R
V
N
V
N
G
G
A
I
A
L
G
H
P
V
G
C
T
G
S
R
L
I
T
T
A
L
H
E
L
E
R
T
D
Q
S
L
A
L
I
T
M
C
A
G
G
A
L
S
T
G
T
I
I
E
R
I
110
HHSearch
80.52
38%
-73
- C7 -
3GOA
2
FADA_SALTY
A:
[1-386]
M
E
Q
V
V
I
V
D
A
I
R
T
P
M
G
R
S
K
G
G
A
F
R
N
V
R
A
E
D
L
S
A
H
L
M
R
S
L
L
A
R
N
P
S
L
----
T
A
A
T
L
D
D
I
Y
W
G
C
V
Q
Q
T
L
E
Q
G
F
N
I
A
R
N
A
A
L
L
A
E
I
P
H
S
V
P
A
V
T
V
N
R
L
C
G
S
S
M
Q
A
L
H
D
A
A
R
M
I
M
T
G
D
A
Q
V
C
L
V
G
G
V
E
H
M
G
---
H
V
P
M
S
H
G
----------
V
-----
D
---
F
H
P
G
L
S
--------
G
M
M
G
L
---
T
A
E
M
L
S
R
L
H
G
I
S
R
E
M
Q
D
Q
F
A
A
R
S
H
A
R
A
W
A
A
T
Q
S
G
A
F
K
T
E
I
I
P
T
G
G
H
D
A
D
------
G
V
L
K
Q
F
N
Y
D
E
V
I
R
P
E
T
T
V
E
A
L
S
T
L
R
P
A
F
D
PV
S
-
G
T
V
T
A
G
T
S
S
A
L
S
D
G
A
A
A
M
L
V
M
S
E
S
R
A
R
E
L
G
L
K
P
R
A
R
I
R
S
M
A
V
V
G
C
D
P
S
I
M
G
Y
G
P
V
P
A
S
K
L
A
L
K
K
A
G
L
S
A
S
D
I
D
V
F
E
M
N
E
A
F
A
A
Q
I
L
P
C
I
K
D
L
G
L
M
EQI
D
E
K
I
N
L
N
G
G
A
I
A
L
G
H
P
L
G
C
S
G
A
R
I
S
T
T
L
I
N
L
M
E
R
K
D
A
Q
F
G
L
A
T
M
C
I
G
L
G
Q
G
I
A
T
V
F
E
R
-
54
PsiBlast_CBE
79.44
38%
-72
- C7 -
4O9C
1
THIL_CUPNH
H:
[5-392]
----
V
I
V
S
A
A
R
T
A
V
G
K
F
-
G
G
S
L
A
K
I
P
A
P
E
L
G
A
V
V
I
K
A
A
L
E
R
A
-
G
V
K
P
E
----
Q
V
S
E
V
I
M
G
Q
V
L
T
A
G
S
-
G
Q
N
P
A
R
Q
A
A
I
K
A
G
L
P
A
M
V
P
A
M
T
I
N
K
V
S
G
S
G
L
K
A
V
M
L
A
A
N
A
I
M
A
G
D
A
E
I
V
V
A
G
G
Q
E
N
M
S
AAP
H
V
L
P
G
S
R
----------
D
G
FRM
G
D
A
K
L
V
D
T
M
I
V
--
D
GL
W
D
V
Y
N
Q
Y
H
MGI
T
A
E
N
V
A
K
E
Y
G
I
T
R
E
A
Q
D
E
F
A
V
G
S
Q
N
K
A
E
A
A
Q
K
A
G
K
F
D
E
E
I
V
P
V
L
I
P
--
Q
R
K
G
D
P
V
A
F
K
T
D
E
F
V
R
Q
G
A
T
L
-
D
S
M
S
G
L
---
K
P
A
F
D
K-
A
-
G
T
V
T
A
A
N
A
S
G
L
N
D
G
A
A
A
V
V
V
M
S
A
A
K
A
K
E
L
G
L
T
P
L
A
T
I
K
S
Y
A
N
A
G
V
D
P
K
V
M
G
M
G
P
V
P
A
S
K
R
A
L
S
R
A
E
W
T
P
Q
D
L
D
L
M
E
I
N
E
A
F
A
A
Q
A
L
A
V
H
Q
Q
M
G
W
D
---
T
S
K
V
N
V
N
G
G
A
I
A
I
G
H
P
I
G
A
S
G
C
R
I
L
V
T
L
L
H
E
M
K
R
R
D
A
K
K
G
L
A
S
L
C
I
G
G
G
M
G
V
A
L
A
V
E
R
-
48
PsiBlast_CBE
78.97
36%
-74
* C7 *
4XL4
7
?
A:
[5-391]
----
V
I
A
S
A
V
R
T
A
I
G
S
Y
-
G
K
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
A
-
G
I
K
P
E
----
D
V
N
E
V
I
L
G
N
V
L
Q
A
G
-
L
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
---
R
A
P
Y
L
A
N
NARWGYRMGN
A
K
---
F
V
D
E
M
I
T
D
G
L
W
--
D
----
A
F
N
D
Y
H
M
G
I
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
---
V
I
K
G
R
K
G
E
T
----
V
V
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
K
--
K
D
G
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
A
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
---
M
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
A
K
K
G
L
A
T
L
S
I
G
G
G
Q
G
T
A
I
L
L
E
K
-
50
PsiBlast_CBE
78.96
36%
-73
- C7 -
4XL3
4
?
A:
[5-391]
----
V
I
A
S
A
V
R
T
A
I
G
S
Y
-
G
K
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
A
-
G
I
K
P
E
----
D
V
N
E
V
I
L
G
N
V
L
Q
A
G
-
L
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
---
R
A
P
Y
L
A
N
NARWGYRMGN
A
K
---
F
V
D
E
M
I
T
D
G
L
W
--
D
----
A
F
N
D
Y
H
M
G
I
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
---
V
I
K
G
R
K
G
E
T
----
V
V
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
K
--
K
D
G
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
A
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
---
M
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
A
K
K
G
L
A
T
L
S
I
G
G
G
Q
G
T
A
I
L
L
E
K
-
47
PsiBlast_CBE
78.90
36%
-76
- C7 -
4XL4
4
?
B:
[5-391]
----
V
I
A
S
A
V
R
T
A
I
G
S
Y
-
G
K
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
A
-
G
I
K
P
E
----
D
V
N
E
V
I
L
G
N
V
L
Q
A
G
-
L
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
---
R
A
P
Y
L
A
N
NARWGYRMGN
A
K
---
F
V
D
E
M
I
T
D
G
L
W
--
D
----
A
F
N
D
Y
H
MGI
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
---
V
I
K
G
R
K
G
E
T
----
V
V
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
K
--
K
D
G
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
A
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
---
M
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
A
K
K
G
L
A
T
L
S
I
G
G
G
Q
G
T
A
I
L
L
E
K
-
43
PsiBlast_CBE
78.77
37%
-76
- C7 -
4WYR
3
THLA_CLOAB
B:
[5-391]
----
V
I
A
S
A
V
R
T
A
I
G
S
Y
-
G
K
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
A
-
G
I
K
P
E
----
D
V
N
E
V
I
L
G
N
V
L
Q
A
G
-
L
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
Q
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
---
R
A
P
Y
L
A
N
NARWGYRMGN
A
K
---
F
V
D
E
M
I
T
D
G
L
W
--
D
--
A
F
Y
D
Y
H
M
G
I--
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
---
V
I
K
G
R
K
G
E
T
----
V
V
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
K
--
K
D
G
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
G
V
D
P
K
I
M
G
Y
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
---
M
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
A
K
K
G
L
A
T
L
C
I
G
G
G
Q
G
T
A
I
L
L
E
K
-
45
PsiBlast_CBE
76.74
37%
-77
- C7 -
4XL2
7
THLA_CLOAB
A:
[1-391]
M
K
E
V
V
I
A
S
A
V
R
T
A
I
G
S
Y
-
G
K
S
L
K
D
V
P
A
V
D
L
G
A
T
A
I
K
E
A
V
K
K
A
-
G
I
K
P
E
----
D
V
N
E
V
I
L
G
N
V
L
Q
A
G
-
L
G
Q
N
P
A
R
Q
A
S
F
K
A
G
L
P
V
E
I
P
A
M
T
I
N
K
V
C
G
S
G
L
R
T
V
S
L
A
A
Q
I
I
K
A
G
D
A
D
V
I
I
A
G
G
M
E
N
M
S
---
R
A
P
Y
L
A
N
NARWGYRMGN
A
K
---
F
V
D
E
M
I
T
D
G
L
W
--
D
----
A
F
N
D
Y
H
M
G
I
T
A
E
N
I
A
E
R
W
N
I
S
R
E
E
Q
D
E
F
A
L
A
S
Q
K
K
A
E
E
A
I
K
S
G
Q
F
K
D
E
I
V
P
V
---
V
I
K
G
R
K
G
E
T
----
V
V
D
T
D
E
H
P
R
F
G
S
T
I
E
G
L
A
K
L
K
P
A
F
K
--
K
D
G
T
V
T
A
G
N
A
S
G
L
N
D
C
A
A
V
L
V
I
M
S
A
E
K
A
K
E
L
G
V
K
P
L
A
K
I
V
S
Y
G
S
A
---------
G
P
F
Y
A
T
K
A
A
I
E
K
A
G
W
T
V
D
E
L
D
L
I
E
S
N
E
A
F
A
A
Q
S
L
A
V
A
K
D
L
K
F
D
---
M
N
K
V
N
V
N
G
G
A
I
A
L
G
H
P
I
G
A
S
G
A
R
I
L
V
T
L
V
H
A
M
Q
K
R
D
A
K
K
G
L
A
T
L
C
I
G
G
G
Q
G
T
A
I
L
L
E
K
-