@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3570c: (2016-05-21 )
MTSIQQRDAQSVLAAIDNLLPEIRDRAQATEDLRRLPDETVKALDDVGFFTLLQPQQWGGLQCDPALFFEATRRLASVCGSTGWVSSIVGVHNWHLALFDQRAQEEVWGEDPSTRISSSYAPMGAGVVVDGGYLVNGSWNWSSGCDHASWTFVGGPVIKDGRPVDFGSFLIPRSEYEIKDVWYVVGLRGTGSNTLVVKDVFVPRHRFLSYKAMNDHTAGGLATNSAPVYKMPWGTMHPTTISAPIVGMAYGAYAAHVEHQGKRVRAAFAGEKAKDDPFAKVRIAEAASDIDAAWRQLIGNVSDEYALLAAGKEIPFELRARARRDQVRATGRSIASIDRLFEASGATALSNEAPIQRFWRDAHAGRVHAANDPERAYVIFGNHEFGLPPGDTMV
Atome Classification :
(20 SA)
------------------.........10........20-.--.......30..-......40........50........60........70........80....----------....90.........-100........110...------------..--------...120---------.--........130.---.......140.......150..-.....160--..-.....170-.....--.--..--.180.......190.......200.......210---.........220.-.-.----.-...230.......240.......250.......260....-...270......-----..280..-.....290.......300......-------.310....-...320....--...330.......340..-------.....350.......360.......370-.......380.......390..----------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------MT
S
I
Q
Q
R
D
A
Q
S
V
L
A
A
I
D
N
L
L
P
-
E
--
I
R
D
R
A
Q
A
T
E
D
L
-
R
RL
P
D
E
T
V
K
A
L
D
DV
G
F
F
T
LLQPQQWGGLQC
D
P
A
L
F
F
E
A
T
R
R
L
A
S
V
CGST
G
W
V
----------
S
S
I
V
G
-VHN
W
H
L
A
L
F
-
D
Q
-
R
A
Q
E
E
VWGED-PST------------RI--------SSSY-----------A--PMG
A
G
V
V
V
DG-
G
---
Y
L
V
NGSWNWSSGCDHA
S
W
T
F
VG-GPVIKDGR--PV-DFG
S
F
L
---
I
PRSE--
Y
--
E
I
--
K
D
V
W
Y
V
V
G
LRGTGS
N
T
L
V
V
K
DVFVPRH
R
F
L
S
Y
-----
K
AMNDHTAGGLAT-N-S----A-
P
V
Y
KMPWGTMHPTTISA
P
I
V
G
M
AY
G
A
Y
A
A
H
V
EHQG
K
R
V
R
A
-AFAG-EKAKDDP-----F
A
K
V
R
I
A
-
E
AA
S
D
I
D
A
A
W
R
Q
L
I
GNVSD
E
Y
A
L
L
-------AAGKEI
P
F
-
E
L
R
A
R
A
R
R
D
Q
--
V
R
A
TG
R
S
I
A
S
I
D
R
L
F
EAS-------GATALSNEA
P
I
Q
R
F
W
R
DAHAG
R
V
HAAND-P
E
R
A
Y
V
I
FGNHEFGLPPGDTMV----------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
96.31
100%
-91
- C3 -
3AFE
-
HSAA_MYCTU
A:
[7-394]
------------------------
R
D
A
Q
S
V
L
A
A
I
D
N
L
L
P
-
E
--
I
R
D
R
A
Q
A
T
E
D
L
-
R
R
L
P
D
E
T
V
K
A
L
D
D
V
G
F
F
T
L
L
Q
P
Q
Q
W
G
G
L
Q
C
D
P
A
L
F
F
E
A
T
R
R
L
A
S
V
C
G
S
T
G
W
V
----------
S
S
I
V
G
-
V
H
N
W
H
L
A
L
F
-
D
Q
-
R
A
Q
E
E
V
W
G
E
D
-
P
S
T
------------
R
I
--------
S
S
S
Y
-----------
A
--
P
M
G
A
G
V
V
V
D
G
-
G
---
Y
L
V
N
G
S
W
N
W
S
S
G
C
D
H
A
S
W
T
F
V
G
-
G
P
V
I
K
D
G
R
--
P
V
-
D
F
G
S
F
L
---
I
P
R
S
E
--
Y
--
E
I
--
K
D
V
W
Y
V
V
G
L
R
G
T
G
S
N
T
L
V
V
K
D
V
F
V
P
R
H
R
F
L
S
Y
-----
K
A
M
N
D
H
T
A
G
G
L
A
T
-
N
-
S
----
A
-
P
V
Y
K
M
P
W
G
T
M
H
P
T
T
I
S
A
P
I
V
G
M
A
Y
G
A
Y
A
A
H
V
E
H
Q
G
K
R
V
R
A
-
A
F
A
G
---
A
K
D
D
P
-----
F
A
K
V
R
I
A
-
E
A
A
S
D
I
D
A
A
W
R
Q
L
I
G
N
V
S
D
E
Y
A
L
L
-------
A
A
G
K
E
I
P
F
-
E
L
R
A
R
A
R
R
D
Q
--
V
R
A
T
G
R
S
I
A
S
I
D
R
L
F
E
A
S
-------
G
A
T
A
L
S
N
E
A
P
I
Q
R
F
W
R
D
A
H
A
G
R
V
H
A
A
N
D
-
P
E
R
A
Y
V
I
F
G
N
H
E
F
G
L
P
P
--
T
M
V
----------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
94.57
100%
-90
- C3 -
3AFF
-
HSAA_MYCTU
A:
[7-394]
------------------------
R
D
A
Q
S
V
L
A
A
I
D
N
L
L
P
-
E
--
I
R
D
R
A
Q
A
T
E
D
L
-
R
R
L
P
D
E
T
V
K
A
L
D
D
V
G
F
F
T
L
L
Q
P
Q
Q
W
G
G
L
Q
C
D
P
A
L
F
F
E
A
T
R
R
L
A
S
V
C
G
S
T
G
W
V
----------
S
S
I
V
G
-
V
H
N
W
H
L
A
L
F
-
D
Q
-
R
A
Q
E
E
V
W
G
E
D
-
P
S
T
------------
R
I
--------
S
S
S
Y
-----------
A
--
P
M
G
A
G
V
V
V
D
G
-
G
---
Y
L
V
N
G
S
W
N
W
S
S
G
C
D
H
A
S
W
T
F
V
G
-
G
P
V
I
K
D
G
R
--
P
V
-
D
F
G
S
F
L
---
I
P
R
S
E
--
Y
--
E
I
--
K
D
V
W
Y
V
V
G
L
R
G
T
G
S
N
T
L
V
V
K
D
V
F
V
P
R
H
R
F
L
S
Y
-----
K
A
M
N
D
H
T
A
G
G
L
A
T
-
N
-
S
----
A
-
P
V
Y
K
M
P
W
G
T
M
H
P
T
T
I
S
A
P
I
V
G
M
A
Y
G
A
Y
A
A
H
V
E
H
Q
-----------------------------
I
A
-
E
A
A
S
D
I
D
A
A
W
R
Q
L
I
G
N
V
S
D
E
Y
A
L
L
-------
A
A
G
K
E
I
P
F
-
E
L
R
A
R
A
R
R
D
Q
--
V
R
A
T
G
R
S
I
A
S
I
D
R
L
F
E
A
S
-------
G
A
T
A
L
S
N
E
A
P
I
Q
R
F
W
R
D
A
H
A
G
R
V
H
A
A
N
D
-
P
E
R
A
Y
V
I
F
G
N
H
E
F
G
L
P
P
G
D
T
M
V
----------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
90.43
75%
-79
- C3 -
2RFQ
2
HSAA_RHOJR
A:
[7-394]
------------------------
H
D
S
H
E
V
M
Q
R
L
D
A
L
L
P
-
T
--
L
R
E
R
A
Q
E
T
E
D
L
-
R
R
I
P
D
D
S
M
K
A
L
Q
E
T
G
F
F
R
L
L
Q
P
E
Q
W
G
G
Y
Q
A
D
P
V
L
F
Y
S
A
V
R
K
I
A
S
A
C
G
S
T
G
W
V
----------
S
S
I
I
G
-
V
H
N
W
H
L
A
L
F
-
S
Q
-
Q
A
Q
E
D
V
W
G
N
D
-
T
D
V
------------
R
I
--------
S
S
S
Y
-----------
A
--
P
M
G
A
G
Q
V
V
D
G
-
G
---
Y
T
V
N
G
A
W
A
W
S
S
G
C
D
H
A
S
W
A
V
L
G
-
G
P
V
I
K
D
G
R
--
P
V
-
D
F
V
S
F
L
---
I
P
R
E
D
--
Y
--
R
I
--
D
D
V
W
N
V
V
G
L
R
G
T
G
S
N
T
V
V
V
E
D
V
F
V
P
T
H
R
V
L
S
F
-----
K
A
M
S
N
L
T
A
P
G
L
E
R
-
N
-
T
----
A
-
P
V
Y
K
M
P
W
G
T
I
H
P
T
T
I
S
A
P
I
V
G
M
A
Y
G
A
Y
D
A
H
V
E
H
Q
G
K
R
V
R
A
-
A
F
A
G
-
E
K
A
K
D
D
P
-----
F
A
K
V
R
I
A
-
E
A
S
S
D
I
D
A
A
W
R
Q
L
S
G
N
V
A
D
E
Y
A
L
L
-------
V
A
G
E
E
V
P
F
-
E
L
R
L
R
A
R
R
D
Q
--
V
R
A
T
G
R
A
I
S
S
I
D
K
L
F
E
S
S
-------
G
A
T
A
L
A
N
G
T
P
L
Q
R
F
W
R
D
A
H
A
G
R
V
H
A
A
N
D
-
P
E
R
A
Y
V
M
Y
G
T
G
E
F
G
L
P
I
T
D
T
M
V
----------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
75.77
41%
-76
- C3 -
2OR0
7
?
A:
[25-388]
-----------------------------
V
L
D
R
I
E
V
V
A
E
-
E
--
I
R
G
Q
A
V
Q
S
E
A
D
-
C
R
L
T
D
A
A
A
G
L
L
R
D
S
G
A
I
R
L
L
Q
P
R
L
Y
G
G
Y
E
V
H
P
R
E
F
A
E
T
V
M
G
V
A
A
L
D
G
A
S
G
W
V
----------
T
G
I
V
G
-
V
H
P
W
E
L
A
F
A
-
D
P
-
Q
V
Q
E
E
I
W
G
E
D
-
N
D
T
------------
W
M
--------
A
S
P
Y
-----------
A
--
P
M
G
V
A
T
P
V
D
G
-
G
---
Y
V
L
K
G
R
W
S
F
S
S
G
T
D
H
C
Q
W
A
F
L
G
-
A
M
V
-
G
D
--AT
P
S
-
S
L
-
H
V
I
---
L
P
R
T
D
--
Y
--
Q
I
V
-
E
D
T
W
D
V
I
G
L
R
G
T
G
S
K
D
L
I
V
D
G
A
F
V
P
G
Y
R
T
L
N
A
-----
A
K
V
M
D
G
R
A
Q
K
E
A
G
-
R
-
P
----
E
-
P
L
F
N
M
P
Y
S
C
M
F
P
L
G
I
T
A
A
V
I
G
I
T
E
G
A
L
A
C
H
I
A
V
Q
K
D
R
V
---
A
I
T
G
-
Q
K
I
K
E
D
P
-----
Y
V
L
S
A
I
G
-
E
S
A
A
E
I
N
A
S
R
V
S
L
I
E
T
A
D
R
F
Y
D
K
V
-------
D
A
G
K
E
I
T
F
-
E
E
R
A
I
G
R
R
T
Q
--
I
A
A
A
W
R
A
V
R
A
A
D
E
I
F
A
R
A
-------
G
G
G
A
L
H
Y
K
T
P
M
Q
R
F
W
R
D
A
H
A
G
L
A
H
A
V
H
V
-
P
-------------------------------------------------------------------------------------------------------------------------------------------------------
48
Fugue
73.06
32%
-69
- C3 -
2JBR
-
HPAH_ACIBA
A:
[24-422]
-------------RLVYT
H
A
Q
T
P
D
V
S
G
V
S
M
L
E
K
I
Q
Q
I
L
P
-
Q
--
I
A
K
N
A
E
S
A
E
Q
L
-
R
R
V
P
D
E
N
I
K
L
L
K
E
I
G
L
H
R
A
F
Q
P
K
V
Y
G
G
L
E
M
S
L
P
D
F
A
N
C
I
V
T
L
A
G
A
C
A
G
T
A
W
A
----------
F
S
L
L
C
-
T
H
S
H
Q
I
A
M
F
-
S
K
-
Q
L
Q
D
E
I
W
L
K
D
-
P
D
A
------------
T
A
--------
S
S
S
I
-----------
A
--
P
F
G
K
V
E
E
V
E
G
-
G
---
I
I
L
N
G
D
Y
G
W
S
S
G
C
D
H
A
E
Y
A
I
V
G
-
F
N
R
F
D
A
D
G
--
N
K
-
I
Y
S
F
G
V
---
I
P
R
S
D
--
Y
--
E
I
--
V
D
N
W
Y
A
Q
A
I
K
S
S
G
S
K
M
L
K
L
V
N
V
F
I
P
E
Y
R
I
S
K
A
-----
K
D
M
M
E
G
K
S
A
G
F
G
L
Y
P
-
D
----
S
-
K
I
F
Y
T
P
Y
R
P
Y
F
A
S
G
F
S
A
V
S
L
G
I
A
E
R
M
I
E
A
F
K
E
K
Q
R
N
R
V
R
A
-
Y
T
-
G
-
A
N
V
G
L
A
T
-----
P
A
L
M
R
I
A
-
E
S
T
H
Q
V
A
A
A
R
A
L
L
E
K
T
W
E
D
H
R
I
H
G
-------
L
N
H
Q
Y
P
N
K
-
E
T
L
A
F
W
R
T
N
Q
--
A
Y
A
V
K
M
C
I
E
A
V
D
R
L
M
A
A
A
-------
G
A
T
S
F
M
D
N
S
E
L
Q
R
L
F
R
D
A
H
M
T
G
A
H
A
Y
T
D
-
Y
D
V
C
A
Q
I
L
G
R
E
L
M
G
M
E
P
D
P
T
M
V
----------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
73.05
34%
-69
- C3 -
2JBR
-
HPAH_ACIBA
A:
[39-422]
----------------------------
S
M
L
E
K
I
Q
Q
I
L
P
-
Q
--
I
A
K
N
A
E
S
A
E
Q
L
-
R
R
V
P
D
E
N
I
K
L
L
K
E
I
G
L
H
R
A
F
Q
P
K
V
Y
G
G
L
E
M
S
L
P
D
F
A
N
C
I
V
T
L
A
G
A
C
A
G
T
A
W
A
----------
F
S
L
L
C
-
T
H
S
H
Q
I
A
M
F
-
S
K
-
Q
L
Q
D
E
I
W
L
K
D
-
P
D
A
------------
T
A
--------
S
S
S
I
-----------
A
--
P
F
G
K
V
E
E
V
E
G
-
G
---
I
I
L
N
G
D
Y
G
W
S
S
G
C
D
H
A
E
Y
A
I
V
G
F
N
R
F
D
A
D
G
N
--
K
I
Y
S
F
G
--
V
---
I
P
R
S
D
--
Y
--
E
I
--
V
D
N
W
Y
A
Q
A
I
K
S
S
G
S
K
M
L
K
L
V
N
V
F
I
P
E
Y
R
I
S
K
A
-----
K
D
M
M
E
G
K
S
A
G
F
G
L
-
Y
P
D
----
S
-
K
I
F
Y
T
P
Y
R
P
Y
F
A
S
G
F
S
A
V
S
L
G
I
A
E
R
M
I
E
A
F
K
E
K
Q
R
N
R
V
R
A
-
Y
T
G
A
-
N
V
G
L
A
T
P
------
A
L
M
R
I
A
-
E
S
T
H
Q
V
A
A
A
-
R
A
L
L
E
K
T
W
E
D
H
R
I
H
-------
G
L
N
H
Q
Y
P
N
K
E
T
L
A
F
W
R
T
N
Q
--
A
Y
A
V
K
M
C
I
E
A
V
D
R
L
M
A
A
A
-------
G
A
T
S
F
M
D
N
S
E
L
Q
R
L
F
R
D
A
H
M
T
G
A
H
A
Y
T
D
-
Y
D
V
C
A
Q
I
L
G
R
E
L
M
G
M
E
P
D
P
T
M
V
----------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
73.02
34%
-69
- C3 -
2JBT
4
HPAH_ACIBA
A:
[39-422]
----------------------------
S
M
L
E
K
I
Q
Q
I
L
P
-
Q
--
I
A
K
N
A
E
S
A
E
Q
L
-
R
R
V
P
D
E
N
I
K
L
L
K
E
I
G
L
H
R
A
F
Q
P
K
V
Y
G
G
L
E
M
S
L
P
D
F
A
N
C
I
V
T
L
A
G
A
C
A
G
T
A
W
A
----------
F
S
L
L
C
-
T
H
S
H
Q
I
A
M
F
-
S
K
-
Q
L
Q
D
E
I
W
L
K
D
-
P
D
A
------------
T
A
--------
S
S
S
I
-----------
A
--
P
F
G
K
V
E
E
V
E
G
-
G
---
I
I
L
N
G
D
Y
G
W
S
S
G
C
D
H
A
E
Y
A
I
V
G
F
N
R
F
D
A
D
G
N
--
K
I
Y
S
F
G
--
V
---
I
P
R
S
D
--
Y
--
E
I
--
V
D
N
W
Y
A
Q
A
I
K
S
S
G
S
K
M
L
K
L
V
N
V
F
I
P
E
Y
R
I
S
K
A
-----
K
D
M
M
E
G
K
S
A
G
F
G
L
-
Y
P
D
----
S
-
K
I
F
Y
T
P
Y
R
P
Y
F
A
S
G
F
S
A
V
S
L
G
I
A
E
R
M
I
E
A
F
K
E
K
Q
R
N
R
V
R
A
-
Y
T
G
A
-
N
V
G
L
A
T
P
------
A
L
M
R
I
A
-
E
S
T
H
Q
V
A
A
A
-
R
A
L
L
E
K
T
W
E
D
H
R
I
H
-------
G
L
N
H
Q
Y
P
N
K
E
T
L
A
F
W
R
T
N
Q
--
A
Y
A
V
K
M
C
I
E
A
V
D
R
L
M
A
A
A
-------
G
A
T
S
F
M
D
N
S
E
L
Q
R
L
F
R
D
A
H
M
T
G
A
H
A
Y
T
D
-
Y
D
V
C
A
Q
I
L
G
R
E
L
M
G
M
E
P
D
P
T
M
V
----------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
72.98
34%
-70
- C3 -
2JBT
4
HPAH_ACIBA
D:
[39-422]
----------------------------
S
M
L
E
K
I
Q
Q
I
L
P
-
Q
--
I
A
K
N
A
E
S
A
E
Q
L
-
R
R
V
P
D
E
N
I
K
L
L
K
E
I
G
L
H
R
A
F
Q
P
K
V
Y
G
G
L
E
M
S
L
P
D
F
A
N
C
I
V
T
L
A
G
A
C
A
G
T
A
W
A
----------
F
S
L
L
C
-
T
H
S
H
Q
I
A
M
F
-
S
K
-
Q
L
Q
D
E
I
W
L
K
D
-
P
D
A
------------
T
A
--------
S
S
S
I
-----------
A
--
P
F
G
K
V
E
E
V
E
G
-
G
---
I
I
L
N
G
D
Y
G
W
S
S
G
C
D
H
A
E
Y
A
I
V
G
F
N
R
F
D
A
D
G
N
--
K
I
Y
S
F
G
--
V
---
I
P
R
S
D
--
Y
--
E
I
--
V
D
N
W
Y
A
Q
A
I
K
S
S
G
S
K
M
L
K
L
V
N
V
F
I
P
E
Y
R
I
S
K
A
-----
K
D
M
M
E
G
K
S
A
G
F
G
L
-
Y
P
D
----
S
-
K
I
F
Y
T
P
Y
R
P
Y
F
A
S
G
F
S
A
V
S
L
G
I
A
E
R
M
I
E
A
F
K
E
K
Q
R
N
R
V
R
A
-
Y
T
G
A
-
N
V
G
L
A
T
P
------
A
L
M
R
I
A
-
E
S
T
H
Q
V
A
A
A
-
R
A
L
L
E
K
T
W
E
D
H
R
I
H
-------
G
L
N
H
Q
Y
P
N
K
E
T
L
A
F
W
R
T
N
Q
--
A
Y
A
V
K
M
C
I
E
A
V
D
R
L
M
A
A
A
-------
G
A
T
S
F
M
D
N
S
E
L
Q
R
L
F
R
D
A
H
M
T
G
A
H
A
Y
T
D
-
Y
D
V
C
A
Q
I
L
G
R
E
L
M
G
M
E
P
D
P
T
M
V
----------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
72.49
34%
-71
- C3 -
2JBT
4
HPAH_ACIBA
B:
[39-422]
----------------------------
S
M
L
E
K
I
Q
Q
I
L
P
-
Q
--
I
A
K
N
A
E
S
A
E
Q
L
-
R
R
V
P
D
E
N
I
K
L
L
K
E
I
G
L
H
R
A
F
Q
P
K
V
Y
G
G
L
E
M
S
L
P
D
F
A
N
C
I
V
T
L
A
G
A
C
A
G
T
A
W
A
----------
F
S
L
L
C
-
T
H
S
H
Q
I
A
M
F
-
S
K
-
Q
L
Q
D
E
I
W
L
K
D
-
P
D
A
------------
T
A
--------
S
S
S
I
-----------
A
--
P
F
G
K
V
E
E
V
E
G
-
G
---
I
I
L
N
G
D
Y
G
W
S
S
G
C
D
H
A
E
Y
A
I
V
G
F
N
R
F
D
A
D
G
N
--
K
I
Y
S
F
G
--
V
---
I
P
R
S
D
--
Y
--
E
I
--
V
D
N
W
Y
A
Q
A
I
K
S
S
G
S
K
M
L
K
L
V
N
V
F
I
P
E
Y
R
I
S
K
A
-----
K
D
M
M
E
G
K
S
A
G
F
G
L
-
Y
P
D
----
S
-
K
I
F
Y
T
P
Y
R
P
Y
F
A
S
G
F
S
A
V
S
L
G
I
A
E
R
M
I
E
A
F
K
E
K
Q
R
N
R
V
R
A
-
Y
T
G
A
-
N
V
G
L
A
T
P
------
A
L
M
R
I
A
-
E
S
T
H
Q
V
A
A
A
-
R
A
L
L
E
K
T
W
E
D
H
R
I
H
-------
G
L
N
H
Q
Y
P
N
K
E
T
L
A
F
W
R
T
N
Q
--
A
Y
A
V
K
M
C
I
E
A
V
D
R
L
M
A
A
A
-------
G
A
T
S
F
M
D
N
S
E
L
Q
R
L
F
R
D
A
H
M
T
G
A
H
A
Y
T
D
-
Y
D
V
C
A
Q
I
L
G
R
E
L
M
G
M
E
P
D
P
T
M
V
----------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
72.13
34%
-70
- C3 -
2JBS
2
HPAH_ACIBA
B:
[39-422]
----------------------------
S
M
L
E
K
I
Q
Q
I
L
P
-
Q
--
I
A
K
N
A
E
S
A
E
Q
L
-
R
R
V
P
D
E
N
I
K
L
L
K
E
I
G
L
H
R
A
F
Q
P
K
V
Y
G
G
L
E
M
S
L
P
D
F
A
N
C
I
V
T
L
A
G
A
C
A
G
T
A
W
A
----------
F
S
L
L
C
-
T
H
S
H
Q
I
A
M
F
-
S
K
-
Q
L
Q
D
E
I
W
L
K
D
-
P
D
A
------------
T
A
--------
S
S
S
I
-----------
A
--
P
F
G
K
V
E
E
V
E
G
-
G
---
I
I
L
N
G
D
Y
G
W
S
S
G
C
D
H
A
E
Y
A
I
V
G
F
N
R
F
D
A
D
G
N
--
K
I
Y
S
F
G
--
V
---
I
P
R
S
D
--
Y
--
E
I
--
V
D
N
W
Y
A
Q
A
I
K
S
S
G
S
K
M
L
K
L
V
N
V
F
I
P
E
Y
R
I
S
K
A
-----
K
D
M
M
E
G
K
S
A
G
F
G
L
-
Y
P
D
----
S
-
K
I
F
Y
T
P
Y
R
P
Y
F
A
S
G
F
S
A
V
S
L
G
I
A
E
R
M
I
E
A
F
K
E
K
Q
R
N
R
V
R
A
-
Y
T
G
A
-
N
V
G
L
A
T
P
------
A
L
M
R
I
A
-
E
S
T
H
Q
V
A
A
A
-
R
A
L
L
E
K
T
W
E
D
H
R
I
H
-------
G
L
N
H
Q
Y
P
N
K
E
T
L
A
F
W
R
T
N
Q
--
A
Y
A
V
K
M
C
I
E
A
V
D
R
L
M
A
A
A
-------
G
A
T
S
F
M
D
N
S
E
L
Q
R
L
F
R
D
A
H
M
T
G
A
H
A
Y
T
D
-
Y
D
V
C
A
Q
I
L
G
R
E
L
M
G
M
E
P
D
P
T
M
V
----------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
71.87
34%
-70
- C3 -
2JBS
2
HPAH_ACIBA
A:
[39-422]
----------------------------
S
M
L
E
K
I
Q
Q
I
L
P
-
Q
--
I
A
K
N
A
E
S
A
E
Q
L
-
R
R
V
P
D
E
N
I
K
L
L
K
E
I
G
L
H
R
A
F
Q
P
K
V
Y
G
G
L
E
M
S
L
P
D
F
A
N
C
I
V
T
L
A
G
A
C
A
G
T
A
W
A
----------
F
S
L
L
C
-
T
H
S
H
Q
I
A
M
F
-
S
K
-
Q
L
Q
D
E
I
W
L
K
D
-
P
D
A
------------
T
A
--------
S
S
S
I
-----------
A
--
P
F
G
K
V
E
E
V
E
G
-
G
---
I
I
L
N
G
D
Y
G
W
S
S
G
C
D
H
A
E
Y
A
I
V
G
F
N
R
F
D
A
D
G
N
--
K
I
Y
S
F
G
--
V
---
I
P
R
S
D
--
Y
--
E
I
--
V
D
N
W
Y
A
Q
A
I
K
S
S
G
S
K
M
L
K
L
V
N
V
F
I
P
E
Y
R
I
S
K
A
-----
K
D
M
M
E
G
K
S
A
G
F
G
L
-
Y
P
D
----
S
-
K
I
F
Y
T
P
Y
R
P
Y
F
A
S
G
F
S
A
V
S
L
G
I
A
E
R
M
I
E
A
F
K
E
K
Q
R
N
R
V
R
A
-
Y
T
G
A
-
N
V
G
L
A
T
P
------
A
L
M
R
I
A
-
E
S
T
H
Q
V
A
A
A
-
R
A
L
L
E
K
T
W
E
D
H
R
I
H
-------
G
L
N
H
Q
Y
P
N
K
E
T
L
A
F
W
R
T
N
Q
--
A
Y
A
V
K
M
C
I
E
A
V
D
R
L
M
A
A
A
-------
G
A
T
S
F
M
D
N
S
E
L
Q
R
L
F
R
D
A
H
M
T
G
A
H
A
Y
T
D
-
Y
D
V
C
A
Q
I
L
G
R
E
L
M
G
M
E
P
D
P
T
M
V
----------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
71.67
34%
-69
- C3 -
2JBS
2
HPAH_ACIBA
C:
[39-422]
----------------------------
S
M
L
E
K
I
Q
Q
I
L
P
-
Q
--
I
A
K
N
A
E
S
A
E
Q
L
-
R
R
V
P
D
E
N
I
K
L
L
K
E
I
G
L
H
R
A
F
Q
P
K
V
Y
G
G
L
E
M
S
L
P
D
F
A
N
C
I
V
T
L
A
G
A
C
A
G
T
A
W
A
----------
F
S
L
L
C
-
T
H
S
H
Q
I
A
M
F
-
S
K
-
Q
L
Q
D
E
I
W
L
K
D
-
P
D
A
------------
T
A
--------
S
S
S
I
-----------
A
--
P
F
G
K
V
E
E
V
E
G
-
G
---
I
I
L
N
G
D
Y
G
W
S
S
G
C
D
H
A
E
Y
A
I
V
G
F
N
R
F
D
A
D
G
N
--
K
I
Y
S
F
G
--
V
---
I
P
R
S
D
--
Y
--
E
I
--
V
D
N
W
Y
A
Q
A
I
K
S
S
G
S
K
M
L
K
L
V
N
V
F
I
P
E
Y
R
I
S
K
A
-----
K
D
M
M
E
G
K
S
A
G
F
G
L
-
Y
P
D
----
S
-
K
I
F
Y
T
P
Y
R
P
Y
F
A
S
G
F
S
A
V
S
L
G
I
A
E
R
M
I
E
A
F
K
E
K
Q
R
N
R
V
R
A
-
Y
T
G
A
-
N
V
G
L
A
T
P
------
A
L
M
R
I
A
-
E
S
T
H
Q
V
A
A
A
-
R
A
L
L
E
K
T
W
E
D
H
R
I
H
-------
G
L
N
H
Q
Y
P
N
K
E
T
L
A
F
W
R
T
N
Q
--
A
Y
A
V
K
M
C
I
E
A
V
D
R
L
M
A
A
A
-------
G
A
T
S
F
M
D
N
S
E
L
Q
R
L
F
R
D
A
H
M
T
G
A
H
A
Y
T
D
-
Y
D
V
C
A
Q
I
L
G
R
E
L
M
G
M
E
P
D
P
T
M
V
----------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
71.60
34%
-70
- C3 -
2JBT
4
HPAH_ACIBA
C:
[39-422]
----------------------------
S
M
L
E
K
I
Q
Q
I
L
P
-
Q
--
I
A
K
N
A
E
S
A
E
Q
L
-
R
R
V
P
D
E
N
I
K
L
L
K
E
I
G
L
H
R
A
F
Q
P
K
V
Y
G
G
L
E
M
S
L
P
D
F
A
N
C
I
V
T
L
A
G
A
C
A
G
T
A
W
A
----------
F
S
L
L
C
-
T
H
S
H
Q
I
A
M
F
-
S
K
-
Q
L
Q
D
E
I
W
L
K
D
-
P
D
A
------------
T
A
--------
S
S
S
I
-----------
A
--
P
F
G
K
V
E
E
V
E
G
-
G
---
I
I
L
N
G
D
Y
G
W
S
S
G
C
D
H
A
E
Y
A
I
V
G
F
N
R
F
D
A
D
G
N
--
K
I
Y
S
F
G
--
V
---
I
P
R
S
D
--
Y
--
E
I
--
V
D
N
W
Y
A
Q
A
I
K
S
S
G
S
K
M
L
K
L
V
N
V
F
I
P
E
Y
R
I
S
K
A
-----
K
D
M
M
E
G
K
S
A
G
F
G
L
-
Y
P
D
----
S
-
K
I
F
Y
T
P
Y
R
P
Y
F
A
S
G
F
S
A
V
S
L
G
I
A
E
R
M
I
E
A
F
K
E
K
Q
R
N
R
V
R
A
-
Y
T
G
A
-
N
V
G
L
A
T
P
------
A
L
M
R
I
A
-
E
S
T
H
Q
V
A
A
A
-
R
A
L
L
E
K
T
W
E
D
H
R
I
H
-------
G
L
N
H
Q
Y
P
N
K
E
T
L
A
F
W
R
T
N
Q
--
A
Y
A
V
K
M
C
I
E
A
V
D
R
L
M
A
A
A
-------
G
A
T
S
F
M
D
N
S
E
L
Q
R
L
F
R
D
A
H
M
T
G
A
H
A
Y
T
D
-
Y
D
V
C
A
Q
I
L
G
R
E
L
M
G
M
E
P
D
P
T
M
V
----------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
71.54
34%
-68
- C3 -
2JBS
2
HPAH_ACIBA
D:
[39-422]
----------------------------
S
M
L
E
K
I
Q
Q
I
L
P
-
Q
--
I
A
K
N
A
E
S
A
E
Q
L
-
R
R
V
P
D
E
N
I
K
L
L
K
E
I
G
L
H
R
A
F
Q
P
K
V
Y
G
G
L
E
M
S
L
P
D
F
A
N
C
I
V
T
L
A
G
A
C
A
G
T
A
W
A
----------
F
S
L
L
C
-
T
H
S
H
Q
I
A
M
F
-
S
K
-
Q
L
Q
D
E
I
W
L
K
D
-
P
D
A
------------
T
A
--------
S
S
S
I
-----------
A
--
P
F
G
K
V
E
E
V
E
G
-
G
---
I
I
L
N
G
D
Y
G
W
S
S
G
C
D
H
A
E
Y
A
I
V
G
F
N
R
F
D
A
D
G
N
--
K
I
Y
S
F
G
--
V
---
I
P
R
S
D
--
Y
--
E
I
--
V
D
N
W
Y
A
Q
A
I
K
S
S
G
S
K
M
L
K
L
V
N
V
F
I
P
E
Y
R
I
S
K
A
-----
K
D
M
M
E
G
K
S
A
G
F
G
L
-
Y
P
D
----
S
-
K
I
F
Y
T
P
Y
R
P
Y
F
A
S
G
F
S
A
V
S
L
G
I
A
E
R
M
I
E
A
F
K
E
K
Q
R
N
R
V
R
A
-
Y
T
G
A
-
N
V
G
L
A
T
P
------
A
L
M
R
I
A
-
E
S
T
H
Q
V
A
A
A
-
R
A
L
L
E
K
T
W
E
D
H
R
I
H
-------
G
L
N
H
Q
Y
P
N
K
E
T
L
A
F
W
R
T
N
Q
--
A
Y
A
V
K
M
C
I
E
A
V
D
R
L
M
A
A
A
-------
G
A
T
S
F
M
D
N
S
E
L
Q
R
L
F
R
D
A
H
M
T
G
A
H
A
Y
T
D
-
Y
D
V
C
A
Q
I
L
G
R
E
L
M
G
M
E
P
D
P
T
M
V
----------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
69.02
32%
-66
- C3 -
2JBR
-
HPAH_ACIBA
A:
[34-421]
-----------------------
D
V
S
G
V
S
M
L
E
K
I
Q
Q
I
L
P
-
Q
--
I
A
K
N
A
E
S
A
E
Q
L
-
R
R
V
P
D
E
N
I
K
L
L
K
E
I
G
L
H
R
A
F
Q
P
K
V
Y
G
G
L
E
M
S
L
P
D
F
A
N
C
I
V
T
L
A
G
A
C
A
G
T
A
W
A
----------
F
S
L
L
C
-
T
H
S
H
Q
I
A
M
F
-
S
K
Q
L
Q
D
E
I
W
L
K
D
P
D
A
T
A
-----------------------
S
S
S
I
----------
A
--
P
F
G
K
V
E
E
V
E
G
-
G
---
I
I
L
N
G
D
Y
G
W
S
S
G
C
D
H
A
E
Y
A
I
V
G
-
F
N
R
F
D
A
D
G
--
N
K
-
I
Y
S
F
G
V
---
I
P
R
S
D
--
Y
--
E
I
--
V
D
N
W
Y
A
Q
A
I
K
S
S
G
S
K
M
L
K
L
V
N
V
F
I
P
E
Y
R
I
S
K
A
K
D
M
M
E
G
K
--
S
--
A
-
G
F
G
L
-
Y
-
P
----
D
S
K
I
F
Y
T
P
Y
R
P
Y
F
A
S
G
F
S
A
V
S
L
G
I
A
E
R
M
I
E
A
F
K
E
K
Q
R
N
R
V
-
R
-
A
Y
T
G
-
A
N
V
G
L
A
T
-----
P
A
L
M
R
I
A
-
E
S
T
H
Q
V
A
A
A
R
A
L
L
E
K
T
W
E
D
H
R
I
H
G
-------
L
N
H
Q
Y
P
N
K
-
E
T
L
A
F
W
R
T
N
Q
--
A
Y
A
V
K
M
C
I
E
A
V
D
R
L
M
A
A
A
-------
G
A
T
S
F
M
D
N
S
E
L
Q
R
L
F
R
D
A
H
M
T
G
A
H
A
Y
T
D
Y
D
-
V
C
A
Q
I
L
G
R
E
L
M
G
M
E
P
D
P
T
M
-----------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
58.48
17%
-45
* C3 *
2JIF
9
ACDSB_HUMAN
A:
[28-402]
---------------------
T
F
T
D
E
E
M
M
I
K
S
S
V
K
K
F
A
Q
E
Q
--
I
A
P
L
V
S
T
M
D
E
N
-
S
K
M
E
K
S
V
I
Q
G
L
F
Q
Q
G
L
M
G
I
E
V
D
P
E
Y
G
G
T
G
A
S
F
L
S
T
V
L
V
I
E
E
L
A
K
V
D
A
S
V
A
V
F
----------
C
E
I
Q
N
T
L
I
N
T
L
I
R
K
H
-
G
T
E
E
Q
K
A
T
Y
L
P
Q
L
T
T
E
K
------------
V
G
S
F
C
LSEAG
A
G
S
D
SF---------
A
--
L
K
T
R
A
D
K
E
G
D
-
Y
---
Y
V
L
N
G
S
K
M
W
I
S
S
A
E
H
A
G
L
F
L
V
M
-
A
N
V
D
P
T
I
G
--
Y
K
-
G
I
T
S
F
L
---
V
D
R
D
T
--
P
G
L
H
I
--
G
K
P
E
N
K
L
G
L
R
A
S
S
T
C
P
L
T
F
E
N
V
K
V
P
E
A
N
I
L
G
Q
-----
I
---
G
--
H
-
G
Y
K
-------------
Y
A
I
G
S
L
N
E
G
R
I
G
I
A
A
Q
M
L
G
L
A
Q
G
C
F
D
Y
T
I
P
Y
I
K
E
R
I
----
Q
F
G
-
K
R
L
F
D
F
Q
-----
G
L
Q
H
Q
V
A
-
H
V
A
T
Q
L
E
A
A
R
L
L
T
Y
N
A
A
R
L
L
E
A
G
K
----------------
P
F
I
K
E
A
S
M
A
K
--
Y
Y
A
S
E
I
A
G
Q
T
T
S
K
C
I
E
W
M
-------
G
G
V
G
Y
T
K
D
Y
P
V
E
K
Y
F
R
D
A
K
I
G
T
I
Y
E
G
A
S
-
N
-
I
Q
L
N
T
I
A
K
H
I
D
A
------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
57.42
25%
-46
- C3 -
4NXL
-
?
A:
[38-393]
--------------------------------------------
R
D
R
A
G
G
S
A
T
A
-
E
R
---
E
D
L
R
A
---
S
G
L
L
S
L
L
V
P
R
E
Y
G
G
W
G
A
D
W
P
T
A
I
E
V
V
R
E
I
A
A
A
D
G
S
L
G
H
L
F
G
Y
H
L
T
N
A
P
M
I
E
L
I
G
-
S
Q
E
Q
E
E
H
L
Y
-
T
Q
-
I
A
Q
N
N
W
W
T
G
N
-
A
S
S
------------
E
N
--------
N
S
H
V
-----------
L
DW
K
V
S
A
T
P
T
E
D
G
-
G
---
Y
V
L
N
G
T
K
H
F
C
S
G
A
K
G
S
D
L
L
F
V
F
-
G
-
V
V
Q
D
D
S
--
P
Q
-
Q
-
G
A
I
I
A
A
A
I
P
T
S
R
--
A
--
G
V
TP
N
D
D
W
A
A
I
G
M
R
Q
T
D
S
G
S
T
D
F
H
N
V
K
V
E
P
D
E
V
L
G
-------
A
P
N
A
F
V
L
A
F
I
Q
S
-
E
-
R
GSL
F
A
-
P
I
A
Q
L
I
F
A
N
V
Y
--------
L
G
I
A
H
G
A
L
D
A
A
R
E
Y
T
R
T
Q
A
R
P
W
T
P
A
G
I
Q
Q
A
T
E
D
P
Y
T
I
R
S
Y
G
E
F
T
I
A
L
Q
G
A
D
A
A
A
R
E
A
A
H
L
L
Q
T
V
W
D
K
G
D
A
L
-------
T
--
P
E
D
R
G
-
E
L
M
V
K
V
S
G
V
K
--
A
L
A
T
N
A
A
L
N
I
S
S
G
V
F
E
V
I
-------
G
A
R
G
T
H
P
R
Y
G
F
D
R
F
W
R
N
V
---
R
T
H
S
L
H
D
-
P
-------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
57.23
20%
-46
- C3 -
3PFD
23
?
A:
[37-380]
----------------------------------------
E
--
I
A
P
Y
A
A
E
V
D
E
K
-
A
R
F
P
E
E
A
L
A
A
L
N
S
S
G
F
S
A
I
H
V
P
E
E
Y
G
G
Q
G
A
D
S
V
A
T
C
I
V
I
E
E
V
A
R
V
D
C
S
A
S
L
I
----------
P
A
V
N
K
-
L
G
T
M
G
L
I
L
R
G
S
E
-
E
L
K
K
Q
V
L
P
A
V
-
A
S
G
------------
E
A
--------
M
A
S
Y
A
LSEREAGSDA
A
--
S
M
R
T
R
A
V
A
D
G
D
D
---
W
I
L
N
G
S
K
C
W
I
T
N
G
G
K
S
T
W
Y
T
V
M
-
A
V
T
D
P
D
K
G
--
A
N
-
G
I
S
A
F
M
---
V
H
K
D
D
EG
F
--
T
V
--
G
P
K
E
R
K
L
G
I
K
G
S
P
T
T
E
L
Y
F
E
N
C
R
I
P
G
D
R
I
I
G
E
-----
P
G
T
G
F
K
T
A
L
A
T
L
D
-
H
-
T
----
R
-
P
------------
T
I
G
A
Q
A
V
G
I
A
Q
G
A
L
D
A
A
I
A
Y
T
K
E
R
K
Q
----
F
G
-
R
P
V
S
D
N
Q
-----
G
V
Q
F
M
L
A
-
D
M
A
M
K
I
E
A
A
-
R
L
M
V
------------------------
Y
-
S
A
A
A
R
A
E
R
G
-G
F
I
S
A
A
S
K
C
F
A
S
-
D
V
A
M
E
V
T
T
D
A
V
Q
L
F
G
G
Y
G
Y
T
Q
D
F
P
V
E
R
M
M
R
D
A
K
I
T
Q
I
Y
E
G
T
N
---------------------------------------------------------------------------------------------------------------------------------------------------------
50
Fugue
56.76
18%
-49
- C3 -
2Z1Q
2
?
B:
[5-577]
KKLWQKGGGWLLEVPE
R
V
Y
T
P
E
D
F
D
E
S
V
K
E
I
A
R
T
T
R
T
F
V
-
E
R
E
V
L
P
L
L
E
R
M
E
H
G
E
L
E
L
N
V
P
L
M
R
K
A
G
E
L
G
L
L
A
I
D
V
P
E
E
Y
G
G
L
D
L
P
K
V
I
S
T
V
V
A
E
E
L
S
G
S
G
G
F
S
V
T
Y
----------
G
A
H
T
S
-
I
G
T
L
P
L
V
Y
F
-
G
T
-
E
E
Q
K
R
K
Y
L
P
K
-
L
A
S
GE
W
I
A
A
Y
C
LTEP
G
S
--------
G
S
D
A
-----------
L
--
A
A
K
T
R
A
T
L
S
E
-
D
GK
H
Y
I
L
N
G
V
K
Q
W
I
S
N
A
G
F
A
H
L
F
T
V
F
-
A
K
V
D
G
E
-------
H
F
T
A
F
L
---
V
E
R
D
T
PG
L
--
S
F
--
G
P
E
E
K
K
M
G
I
K
A
S
S
T
R
Q
V
I
L
E
D
V
K
V
P
V
E
N
V
L
G
-----------------
E
I
-
G
-
K
----
G
-
H
K
I
A
F
N
V
L
N
V
G
R
Y
K
L
G
A
G
A
V
G
G
A
K
R
A
L
E
L
S
A
Q
Y
A
T
Q
R
V
Q
F
----
G
-
R
P
I
G
R
F
G
-----
L
I
Q
Q
K
L
G
-
E
M
A
S
R
I
Y
A
A
E
S
A
V
Y
R
T
V
G
L
I
D
E
A
L
LGKKG
P
E
A
V
M
A
G
I
E
--
E
Y
A
V
E
A
S
I
I
K
--
V
L
G
S
E
V
L
D
Y
V
V
D
E
G
V
Q
I
H
-------
G
G
Y
G
Y
S
Q
E
Y
P
I
E
R
A
Y
R
D
A
R
I
N
R
I
F
E
G
T
N
-
E
I
N
R
L
L
I
P
G
M
L
L
R
R
A
E
P
E
D
L
E
L
H
Q
V
Q
N
L
K
K
L
A
L
M
V
A
G
L
A
V
Q
K
YGQGVEEE
Q
E
V
L
G
A
V
A
D
I
L
I
D
A
Y
A
A
E
S
A
L
L
R
A
R
R
L
GGL
A
P
V
L
A
R
I
Y
L
A
Q
A
L
D
R
A
Q
A
G
A
L
S
V
LPRLVEG
D
E
A
R
V
V
Y
S
A
A
R
R
L
T
KREPGD
L
V
A
L
R
R
Q
A
A
E
A
V
L
E
A
GGYPIPR
8
PsiBlast_PDB
56.62
25%
-50
- C3 -
4DOY
1
?
A:
[58-413]
--------------------------------------------
R
D
R
A
G
G
S
A
T
A
-
E
R
---
E
D
L
R
A
---
S
G
L
L
S
L
L
V
P
R
E
Y
G
G
W
G
A
D
W
P
T
A
I
E
V
V
R
E
I
A
A
A
D
G
S
L
G
H
L
F
G
Y
H
L
T
N
A
P
M
I
E
L
I
G
-
S
Q
E
Q
E
E
H
L
Y
-
T
Q
-
I
A
Q
N
N
W
W
T
G
N
-
A
S
S
------------
E
N
--------
N
S
H
V
-----------
L
DW
K
V
S
A
T
P
T
E
D
G
-
G
---
Y
V
L
N
G
T
K
H
F
C
S
G
A
K
G
S
D
L
L
F
V
F
-
G
-
V
V
Q
D
D
S
--
P
Q
-
Q
-
G
A
I
I
A
A
A
I
P
T
S
R
--
A
--
G
V
TP
N
D
D
W
A
A
I
G
M
R
Q
T
D
S
G
S
T
D
F
H
N
V
K
V
E
P
D
E
V
L
G
-------
A
P
N
A
F
V
L
A
F
I
Q
S
-
E
-
R
GSL
F
A
-
P
I
A
Q
L
I
F
A
N
V
Y
--------
L
G
I
A
H
G
A
L
D
A
A
R
E
Y
T
R
T
Q
A
R
P
W
T
P
A
G
I
Q
Q
A
T
E
D
P
Y
T
I
R
S
Y
G
E
F
T
I
A
L
Q
G
A
D
A
A
A
R
E
A
A
H
L
L
Q
T
V
W
D
K
G
D
A
L
-------
T
--
P
E
D
R
G
-
E
L
M
V
K
V
S
G
V
K
--
A
L
A
T
N
A
A
L
N
I
S
S
G
V
F
E
V
I
-------
G
A
R
G
T
H
P
R
Y
G
F
D
R
F
W
R
N
V
---
R
T
H
S
L
H
D
-
P
-------------------------------------------------------------------------------------------------------------------------------------------------------