@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3589: (2016-05-21 )
MPHILPEPSVTGPRHISDTNLLAWYQRSHRDLPWREPGVSPWQILVSEFMLQQTPAARVLAIWPDWVRRWPTPSATATASTADVLRAWGKLGYPRRAKRLHECATVIARDHNDVVPDDIEILVTLPGVGSYTARAVACFAYRQRVPVVDTNVRRVVARAVHGRADAGAPSVPRDHADVLALLPHRETAPEFSVALMELGATVCTARTPRCGLCPLDWCAWRHAGYPPSDGPPRRGQAYTGTDRQVRGRLLDVLRAAEFPVTRAELDVAWLTDTAQRDRALESLLADALVTRTVDGRFALPGEGF
Atome Classification :
(24 SA)
.........10........20........30.-........40-------........50........60........70........80........90........100.......110.......120..-.....130.......140.......150.......160......-.170.......180.......190.......200.......210....-.-..220......--.230.......240.......250....--------...260------.....------...270.......280.......290.......300..----------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MPHILPEPSVTGPRHISDT
N
L
L
A
W
Y
Q
R
SHR-D-LPWREPGV
S
P
-------
W
Q
I
L
V
S
E
F
M
L
QQTPA
A
R
V
L
A
I
W
P
D
W
V
R
RWPTPSATATA
S
T
A
D
V
L
R
A
W
G
KLGY
P
R
R
A
K
R
L
H
E
C
A
T
V
I
ARDHNDVVPDD
I
E
I
L
V
T-LPGVG
S
Y
T
A
R
A
V
A
C
F
A
Y
R
QRVPVVD
T
N
V
R
R
V
V
A
R
A
VHGRADAGA-PSVP
R
D
H
A
D
V
L
A
LLPHRETA
P
E
F
S
V
A
L
M
ELGA
T
V
CTARTPRCGLCP
L
D
-
W
-
C
A
WRHAGYPPS--DGPPRRGQAYTGT
D
R
Q
V
R
G
R
L
L
D
V
L
R
A
A--------EFPV
T
-------
R
A
E
L
D
------
V
A
WLT
D
T
A
Q
R
D
R
A
L
E
S
L
L
A
D
A
L
V
T
RTVDGRFALPGEGF----------------------------
48
Fugue
88.57
31%
-85
- C3 -
1RRQ
4
MUTY_GEOSE
A:
[12-362]
------------
P
A
R
E
F
Q
R
D
L
L
D
W
F
A
R
E
R
R
-
D
-
L
P
W
R
K
D
R
-
D
P
-------
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
-
C
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
-
A
Y
C
Q
A
F
A
E
G
V
A
E
E
LP
V
K
M
V
K
Q
V
P
L
A
V
A
V
L
A
D
D
E
G
R
V
L
I
R
K
R
D
S
TGLLAN
L
W
E
F
P
S
C
ETDGADG
K
E
K
L
E
Q
M
VGL
Q
V
E
L
T
E
P
I
V
S
F
E
H
A
F
S
H
L
V
W
Q
L
T
V
F
P
G
R
L
V
H
G
G
P
V
E
E
P
Y
R
L
A
P
EDELKA
Y
A
F
P
V
S
H
Q
R
V
W
R
E
Y
K
E
W
A
7
PsiBlast_PDB
88.43
39%
-115
- C3 -
3G0Q
4
MUTY_GEOSE
A:
[8-214]
-------------------
D
L
L
D
W
F
A
R
E
R
R
-
D
-
L
P
W
R
K
-
D
R
D
P
-------
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
-
C
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
-
C
-----------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
88.29
39%
-111
- C3 -
4YPH
4
MUTY_GEOSE
A:
[19-225]
-------------------
D
L
L
D
W
F
A
R
E
R
R
-
D
-
L
P
W
R
K
-
D
R
D
P
-------
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
-
C
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
-
C
-----------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
88.03
39%
-111
- C3 -
4YOQ
5
MUTY_GEOSE
A:
[19-225]
-------------------
D
L
L
D
W
F
A
R
E
R
R
-
D
-
L
P
W
R
K
-
D
R
D
P
-------
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
-
C
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
-
C
-----------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
87.76
38%
-113
- C3 -
1RRQ
4
MUTY_GEOSE
A:
[19-225]
-------------------
D
L
L
D
W
F
A
R
E
R
R
-
D
-
L
P
W
R
K
-
D
R
D
P
-------
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
-
C
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
-
C
-----------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
87.55
35%
-114
- C3 -
1KG6
8
MUTY_ECOLI
A:
[9-205]
-------------------
Q
V
L
D
W
Y
D
K
Y
G
R
-
K
T
L
P
W
-
Q
I
D
K
T
P
-------
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
R
R
V
L
A
R
C
Y
A
V
S
G
W
P
G
K
-
K
E
V
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
87.12
34%
-113
- C3 -
1WEF
1
MUTY_ECOLI
A:
[9-205]
-------------------
Q
V
L
D
W
Y
D
K
Y
G
R
A
T
-
L
P
W
-
Q
I
D
K
T
P
-------
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
C
Y
A
V
S
G
W
P
G
K
-
K
E
V
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
86.97
39%
-109
- C3 -
1VRL
5
MUTY_GEOSE
A:
[19-223]
-------------------
D
L
L
D
W
F
A
R
E
R
R
-
D
-
L
P
W
R
K
-
D
R
D
P
-------
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
-
P
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
-
C
-----------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
86.92
39%
-112
- C3 -
3FSP
4
MUTY_GEOSE
A:
[19-217]
-------------------
D
L
L
D
W
F
A
R
E
R
R
-
D
-
L
P
W
R
K
-
D
R
D
P
-------
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
-
P
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
-
C
-----------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
86.58
34%
-110
- C3 -
1MUY
4
MUTY_ECOLI
A:
[9-205]
-------------------
Q
V
L
D
W
Y
D
K
Y
G
R
-
K
T
L
P
W
-
Q
I
D
K
T
P
-------
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
C
Y
A
V
S
G
W
P
G
K
-
K
E
V
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------
19
PsiBlast_PDB
86.06
34%
-109
- C3 -
1MUD
4
MUTY_ECOLI
A:
[9-205]
-------------------
Q
V
L
D
W
Y
D
K
Y
G
R
-
K
T
L
P
W
-
Q
I
D
K
T
P
-------
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
N
G
N
V
K
R
V
L
A
R
C
Y
A
V
S
G
W
P
G
K
-
K
E
V
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------
20
PsiBlast_PDB
86.02
34%
-109
- C3 -
1MUN
7
MUTY_ECOLI
A:
[9-205]
-------------------
Q
V
L
D
W
Y
D
K
Y
G
R
-
K
T
L
P
W
-
Q
I
D
K
T
P
-------
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
N
G
N
V
K
R
V
L
A
R
C
Y
A
V
S
G
W
P
G
K
-
K
E
V
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------
15
PsiBlast_PDB
86.02
34%
-112
- C3 -
1KG3
7
MUTY_ECOLI
A:
[9-205]
-------------------
Q
V
L
D
W
Y
D
K
Y
G
R
-
K
T
L
P
W
-
Q
I
D
K
T
P
-------
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
C
Y
A
V
S
G
W
P
G
K
-
K
E
V
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
85.92
34%
-111
- C3 -
1WEG
4
MUTY_ECOLI
A:
[9-205]
-------------------
Q
V
L
D
W
Y
D
K
Y
G
R
-
K
T
L
P
W
-
Q
I
D
K
T
P
-------
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
A
R
V
L
A
R
C
Y
A
V
S
G
W
P
G
K
-
K
E
V
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
85.83
34%
-110
- C3 -
1KG4
4
MUTY_ECOLI
A:
[9-205]
-------------------
Q
V
L
D
W
Y
D
K
Y
G
R
-
K
T
L
P
W
-
Q
I
D
K
T
P
-------
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
A
R
V
L
A
R
C
Y
A
V
S
G
W
P
G
K
-
K
E
V
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
85.68
38%
-105
- C3 -
3N5N
2
MUTYH_HUMAN
Y:
[21-229]
-------------------
S
L
L
S
W
Y
D
Q
E
K
R
-
D
-
L
P
W
R
R
R
A
E
D
E
MDLDRRA
Y
A
V
W
V
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
N
Y
Y
T
G
W
M
Q
K
W
P
T
L
Q
D
L
A
S
A
S
L
E
E
V
N
Q
L
W
A
G
L
G
Y
Y
S
R
G
R
R
L
Q
E
G
A
R
K
V
V
E
E
L
G
G
H
M
P
R
T
A
E
T
L
Q
Q
L
L
P
G
V
G
R
Y
T
A
G
A
I
A
S
I
A
F
G
Q
A
T
G
V
V
D
G
N
V
A
R
V
L
C
R
V
R
A
I
G
A
D
P
S
S
-
T
L
V
S
Q
Q
L
W
G
L
A
Q
Q
L
V
D
P
A
R
P
G
D
F
N
Q
A
A
M
E
L
G
A
T
V
C
T
P
Q
R
P
L
C
S
Q
C
P
V
E
---------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
85.55
34%
-110
- C3 -
1KG2
6
MUTY_ECOLI
A:
[9-205]
-------------------
Q
V
L
D
W
Y
D
K
Y
G
R
-
K
T
L
P
W
-
Q
I
D
K
T
P
-------
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
C
Y
A
V
S
G
W
P
G
K
-
K
E
V
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
85.50
38%
-102
- C3 -
3N5N
1
MUTYH_HUMAN
X:
[21-230]
-------------------
S
L
L
S
W
Y
D
Q
E
K
R
-
D
-
L
P
W
R
R
R
A
E
D
E
MDLDRRA
Y
A
V
W
V
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
N
Y
Y
T
G
W
M
Q
K
W
P
T
L
Q
D
L
A
S
A
S
L
E
E
V
N
Q
L
W
A
G
L
G
Y
Y
S
R
G
R
R
L
Q
E
G
A
R
K
V
V
E
E
L
G
G
H
M
P
R
T
A
E
T
L
Q
Q
L
L
P
G
V
G
R
Y
T
A
G
A
I
A
S
I
A
F
G
Q
A
T
G
V
V
D
G
N
V
A
R
V
L
C
R
V
R
A
I
G
A
D
P
S
S
-
T
L
V
S
Q
Q
L
W
G
L
A
Q
Q
L
V
D
P
A
R
P
G
D
F
N
Q
A
A
M
E
L
G
A
T
V
C
T
P
Q
R
P
L
C
S
Q
C
P
V
E
---------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
85.45
38%
-108
- C3 -
4YPR
3
MUTY_GEOSE
A:
[19-217]
-------------------
D
L
L
D
W
F
A
R
E
R
R
-
D
-
L
P
W
R
K
-
D
R
D
P
-------
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
-
C
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
-
C
-----------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
85.44
38%
-108
- C3 -
4YPR
3
MUTY_GEOSE
B:
[19-222]
-------------------
D
L
L
D
W
F
A
R
E
R
R
-
D
-
L
P
W
R
K
-
D
R
D
P
-------
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
-
C
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
-
C
-----------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
85.42
39%
-108
- C3 -
1RRS
4
MUTY_GEOSE
A:
[19-224]
-------------------
D
L
L
D
W
F
A
R
E
R
R
-
D
-
L
P
W
R
K
-
D
R
D
P
-------
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
N
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
-
P
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
-
C
-----------------------------------------------------------------------------------------------------------------------------------------
18
PsiBlast_PDB
84.83
34%
-112
- C3 -
1KG5
6
MUTY_ECOLI
A:
[9-205]
-------------------
Q
V
L
D
W
Y
D
K
Y
G
R
-
K
T
L
P
W
-
Q
I
D
K
T
P
-------
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
Q
R
V
L
A
R
C
Y
A
V
S
G
W
P
G
K
-
K
E
V
E
N
K
L
W
S
L
S
E
Q
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
I
C
T
R
S
K
P
K
C
S
L
C
P
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------
28
HHSearch
83.32
37%
-96
- C3 -
3FSP
4
MUTY_GEOSE
A:
[11-229]
-----------
F
P
A
R
E
F
Q
R
D
L
L
D
W
F
A
R
E
R
R
-
D
-
L
P
W
R
K
D
-
R
D
P
-------
Y
K
V
W
V
S
E
V
M
L
Q
Q
T
R
V
E
T
V
I
P
Y
F
E
Q
F
I
D
R
F
P
T
L
E
A
L
A
D
A
D
E
D
E
V
L
K
A
W
E
G
L
G
Y
Y
S
R
V
R
N
L
H
A
A
V
K
E
V
K
T
R
Y
G
G
K
V
P
D
D
P
D
E
F
S
R
-
L
K
G
V
G
P
Y
T
V
G
A
V
L
S
L
A
Y
G
V
P
E
P
A
V
D
G
N
V
M
R
V
L
S
R
L
F
L
V
T
D
D
I
A
K
P
S
T
R
K
R
F
E
Q
I
V
R
E
I
M
A
Y
E
-
N
P
G
A
F
N
E
A
L
I
E
L
G
A
L
V
C
T
P
R
R
P
S
C
L
L
C
P
V
Q
A
Y
-
C
Q
A
F
A
E
G
V
A
E
E
--
L
P
---------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
83.07
34%
-110
- C3 -
1WEI
5
MUTY_ECOLI
A:
[9-205]
-------------------
Q
V
L
D
W
Y
D
K
Y
G
R
A
T
-
L
P
W
-
Q
I
D
K
T
P
-------
Y
K
V
W
L
S
E
V
M
L
Q
Q
T
Q
V
A
T
V
I
P
Y
F
E
R
F
M
A
R
F
P
T
V
T
D
L
A
N
A
P
L
D
E
V
L
H
L
W
T
G
L
G
Y
Y
A
R
A
R
N
L
H
K
A
A
Q
Q
V
A
T
L
H
G
G
K
F
P
E
T
F
E
E
V
A
A
-
L
P
G
V
G
R
S
T
A
G
A
I
L
S
L
S
L
G
K
H
F
P
I
L
D
G
N
V
K
R
V
L
A
R
-
Y
A
V
S
G
W
P
G
K
-
K
E
V
E
N
K
L
W
-
L
S
E
Q
V
T
P
A
V
G
V
E
R
F
N
Q
A
M
M
D
L
G
A
M
-
C
T
R
S
K
P
K
C
-
L
C
P
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------