@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3608c: (2016-05-21 )
MSPAPVQVMGVLNVTDDSFSDGGCYLDLDDAVKHGLAMAAAGAGIVDVGGESSRPGATRVDPAVETSRVIPVVKELAAQGITVSIDTMRADVARAALQNGAQMVNDVSGGRADPAMGPLLAEADVPWVLMHWRAVSADTPHVPVRYGNVVAEVRADLLASVADAVAAGVDPARLVLDPGLGFAKTAQHNWAILHALPELVATGIPVLVGASRKRFLGALLAGPDGVMRPTDGRDTATAVISALAALHGAWGVRVHDVRASVDAIKVVEAWMGAERIERDG
Atome Classification :
(61 SA)
.......------------..10........20......-..30........40----.........50........60........70.......-.------80.........90........100.......110.......120.-......130------..-......140.....----------------------------..150-------------.......160....-...170.......180--...-..-...190.......200---.----------------........210.......220........230----........240.......250.......260.......270.......280
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSPA
P
V
Q
------------
V
M
G
V
L
NVTDDSFSDG
G
C
Y
L
D
-
L
D
D
A
V
K
H
G
L
A
M
AA-----AGA
G
I
V
DVGGESSRPGATRVDPAVET
S
R
V
I
P
V
V
K
E
L
A
A-Q------
G
-
I
T
V
S
I
D
T
M
R
A
D
V
A
R
A
A
L
Q
N
G
A
Q
M
V
N
DVSGGRADPAMGPLLAEA-DV
P
W
V
L
M
H
-------
W
R
-AVSADTPH
V
P
V
R
Y
G
----------------------------
N
V
V
A
E
-------------
V
R
A
D
L
L
A
S
V
A
D
A
V
A-AGV
D
P
A
R
L
V
LDPGLG---FAK-TA-QH
N
W
A
I
L
H
A
L
P
E
L
V
-----A----------------TGI
P
V
L
VGA
S
R
K
R
F
L
G
A
L
L-AGPDGVMRPTD-----G
R
D
T
A
T
A
V
I
S
A
L
A
A
L
H
GAW
G
V
R
V
H
D
VRAS
V
D
A
I
K
V
V
E
A
W
M
G
A
E
R
IERDG
85
HHSearch
98.20
100%
-121
- C6 -
1EYE
2
DHPS1_MYCTU
A:
[5-274]
----
P
V
Q
------------
V
M
G
V
L
N
V
T
D
D
S
F
S
D
G
G
C
Y
L
D
-
L
D
D
A
V
K
H
G
L
A
M
A
A
-----
A
G
A
G
I
V
D
V
G
G
--------------
E
T
S
R
V
I
P
V
V
K
E
L
A
A
-
Q
------
G
-
I
T
V
S
I
D
T
M
R
A
D
V
A
R
A
A
L
Q
N
G
A
Q
M
V
N
D
V
S
G
G
R
A
D
P
A
M
G
P
L
L
A
E
A
-
D
V
P
W
V
L
M
H
-------
W
R
-
A
V
S
A
D
T
P
H
V
P
V
R
Y
G
----------------------------
N
V
V
A
E
-------------
V
R
A
D
L
L
A
S
V
A
D
A
V
A
-
A
G
V
D
P
A
R
L
V
L
D
P
G
L
G
---
F
A
K
-
T
A
-
Q
H
N
W
A
I
L
H
A
L
P
E
L
V
-----
A
----------------
T
G
I
P
V
L
V
G
A
S
R
K
R
F
L
G
A
L
L
-
A
G
P
D
G
V
M
R
P
T
D
-----
G
R
D
T
A
T
A
V
I
S
A
L
A
A
L
H
G
A
W
G
V
R
V
H
D
V
R
A
S
V
D
A
I
K
V
V
E
A
W
M
G
A
E
------
1
PsiBlast_PDB
98.20
100%
-121
- C6 -
1EYE
2
DHPS1_MYCTU
A:
[5-274]
----
P
V
Q
------------
V
M
G
V
L
N
V
T
D
D
S
F
S
D
G
G
C
Y
L
D
-
L
D
D
A
V
K
H
G
L
A
M
A
A
-----
A
G
A
G
I
V
D
V
G
G
--------------
E
T
S
R
V
I
P
V
V
K
E
L
A
A
-
Q
------
G
-
I
T
V
S
I
D
T
M
R
A
D
V
A
R
A
A
L
Q
N
G
A
Q
M
V
N
D
V
S
G
G
R
A
D
P
A
M
G
P
L
L
A
E
A
-
D
V
P
W
V
L
M
H
-------
W
R
-
A
V
S
A
D
T
P
H
V
P
V
R
Y
G
----------------------------
N
V
V
A
E
-------------
V
R
A
D
L
L
A
S
V
A
D
A
V
A
-
A
G
V
D
P
A
R
L
V
L
D
P
G
L
G
---
F
A
K
-
T
A
-
Q
H
N
W
A
I
L
H
A
L
P
E
L
V
-----
A
----------------
T
G
I
P
V
L
V
G
A
S
R
K
R
F
L
G
A
L
L
-
A
G
P
D
G
V
M
R
P
T
D
-----
G
R
D
T
A
T
A
V
I
S
A
L
A
A
L
H
G
A
W
G
V
R
V
H
D
V
R
A
S
V
D
A
I
K
V
V
E
A
W
M
G
A
E
------
68
PsiBlast_CBE
79.56
40%
-109
- C6 -
2Y5S
13
?
A:
[8-292]
--
P
A
P
L
Q
CGRFELTFE
R
P
L
V
M
G
I
L
N
A
T
P
----------
A
-
R
D
D
A
L
R
R
A
E
R
M
I
A
-----
E
G
A
D
L
L
D
I
G
G
E
S
T
R
P
G
A
P
P
V
P
L
D
E
E
L
A
R
V
I
P
L
V
E
A
L
R
P
-
L
------
N
-
V
P
L
S
I
D
T
Y
K
P
A
V
M
R
A
A
L
A
A
G
A
D
L
I
N
D
I
W
G
F
R
-
Q
P
G
A
I
D
A
V
R
D
G
-
N
S
G
L
C
A
M
H
-------
M
L
-
G
E
P
Q
T
M
Q
V
G
E
P
D
Y
G
----------------------------
D
V
V
T
D
-------------
V
R
-
D
F
L
A
A
R
A
Q
A
L
R
D
A
G
V
A
A
E
R
I
C
V
D
P
G
F
G
---
F
G
K
A
V
V
-
D
D
N
Y
A
L
L
A
A
L
P
D
T
A
P
A
R
PD
G
----------------
R
A
Y
P
I
L
A
G
M
S
R
K
S
M
L
G
A
V
I
-
G
G
-----
K
P
P
L
-----
E
R
V
A
A
S
V
A
A
A
L
C
A
V
E
R
G
A
A
I
V
R
V
H
D
V
A
A
T
V
D
A
L
S
V
W
N
A
V
R
A
A
A
R
-----
67
PsiBlast_CBE
77.82
40%
-107
- C6 -
2Y5S
9
?
B:
[8-292]
--
P
A
P
L
Q
CGRFELTFE
R
P
L
V
M
G
I
L
N
A
T
P
----------
A
-
R
D
D
A
L
R
R
A
E
R
M
I
A
-----
E
G
A
D
L
L
D
I
G
G
E
S
T
R
P
G
A
P
P
V
P
L
D
E
E
L
A
R
V
I
P
L
V
E
A
L
R
P
-
L
------
N
-
V
P
L
S
I
D
T
Y
K
P
A
V
M
R
A
A
L
A
A
G
A
D
L
I
N
D
I
W
G
F
R
-
Q
P
G
A
I
D
A
V
R
D
G
-
N
S
G
L
C
A
M
H
-------
M
L
-
G
E
P
Q
T
M
Q
V
G
E
P
D
Y
G
----------------------------
D
V
V
T
D
-------------
V
R
-
D
F
L
A
A
R
A
Q
A
L
R
D
A
G
V
A
A
E
R
I
C
V
D
P
G
F
G
---
F
G
K
A
V
V
-
D
D
N
Y
A
L
L
A
A
L
P
D
T
A
P
A
R
PD
G
----------------
R
A
Y
P
I
L
A
G
M
S
R
K
S
M
L
G
A
V
I
-
G
G
-----
K
P
P
L
-----
E
R
V
A
A
S
V
A
A
A
L
C
A
V
E
R
G
A
A
I
V
R
V
H
D
V
A
A
T
V
D
A
L
S
V
W
N
A
V
R
A
A
A
R
-----
24
PsiBlast_CBE
77.42
39%
-114
- C6 -
4NIL
7
?
B:
[42-293]
-------------------
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
-------
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V
-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
4
PsiBlast_PDB
77.19
40%
-99
- C6 -
1AJZ
2
DHPS_ECOLI
A:
[16-280]
------
H
------------
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
T
H
N
S
-
L
I
D
A
V
K
H
A
N
L
M
I
N
-----
A
G
A
T
I
I
D
V
G
G
E
S
T
R
P
G
A
A
E
V
S
V
E
E
E
L
Q
R
V
I
P
V
V
E
A
I
A
Q
-
R
F-----
E
-
V
W
I
S
V
D
T
S
K
P
E
V
I
R
E
S
A
K
V
G
A
H
I
I
N
D
I
R
-
S
L
S
E
P
G
A
L
E
A
A
A
E
T
-
G
L
P
V
C
L
M
H
-------
M
Q
-
G
N
P
K
T
M
Q
E
A
P
-
K
Y
D
----------------------------
D
V
F
A
E
-------------
V
N
R
Y
F
I
E
Q
I
A
R
C
E
Q
-
A
G
I
A
K
E
K
L
L
L
D
P
G
F
G
---
F
G
K
-
N
L
-
S
H
N
Y
S
L
L
A
R
L
A
E
F
H
-----
H
----------------
F
N
L
P
L
L
V
G
M
S
R
K
S
M
I
G
Q
L
L
N
V
G
P
-------
S
-----
E
R
L
S
G
S
L
A
C
A
V
I
A
A
M
Q
G
A
H
I
I
R
V
H
D
V
K
E
T
V
E
A
M
R
V
V
E
A
T
L
S
A
K
E
N
K
R
--
46
PsiBlast_CBE
77.06
39%
-113
- C6 -
3H2E
6
?
B:
[42-293]
-------------------
I
M
G
I
L
N
V
T
----
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V
-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
3
PsiBlast_PDB
76.86
40%
-101
- C6 -
1AJ2
2
DHPS_ECOLI
A:
[16-280]
------
H
------------
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
T
H
N
S
-
L
I
D
A
V
K
H
A
N
L
M
I
N
-----
A
G
A
T
I
I
D
V
G
G
E
S
T
R
P
G
A
A
E
V
S
V
E
E
E
L
Q
R
V
I
P
V
V
E
A
I
A
Q
-
R
F-----
E
-
V
W
I
S
V
D
T
S
K
P
E
V
I
R
E
S
A
K
V
G
A
H
I
I
N
D
I
R
-
S
L
S
E
P
G
A
L
E
A
A
A
E
T
-
G
L
P
V
C
L
M
H
-------
M
Q
-
G
N
P
K
T
M
Q
E
A
P
-
K
Y
D
----------------------------
D
V
F
A
E
-------------
V
N
R
Y
F
I
E
Q
I
A
R
C
E
Q
-
A
G
I
A
K
E
K
L
L
L
D
P
G
F
G
---
F
G
K
-
N
L
-
S
H
N
Y
S
L
L
A
R
L
A
E
F
H
-----
H
----------------
F
N
L
P
L
L
V
G
M
S
R
K
S
M
I
G
Q
L
L
N
V
G
P
-------
S
-----
E
R
L
S
G
S
L
A
C
A
V
I
A
A
M
Q
G
A
H
I
I
R
V
H
D
V
K
E
T
V
E
A
M
R
V
V
E
A
T
L
S
A
K
E
N
K
R
--
87
HHSearch
76.81
41%
-103
- C6 -
2Y5S
13
?
A:
[20-292]
--
F
E
R
P
L
------------
V
M
G
I
L
N
A
T
P
----------
A
-
R
D
D
A
L
R
R
A
E
R
M
I
A
-----
E
G
A
D
L
L
D
I
G
G
E
S
T
R
P
G
A
P
P
V
P
L
D
E
E
L
A
R
V
I
P
L
V
E
A
L
R
P
-
L
------
N
-
V
P
L
S
I
D
T
Y
K
P
A
V
M
R
A
A
L
A
A
G
A
D
L
I
N
D
I
W
G
F
R
-
Q
P
G
A
I
D
A
V
R
D
G
-
N
S
G
L
C
A
M
H
-------
M
L
-
G
E
P
Q
T
M
Q
V
G
E
P
D
Y
G
----------------------------
D
V
V
T
D
-------------
V
R
D
F
L
A
A
R
A
Q
A
L
R
D
-
A
G
V
A
A
E
R
I
C
V
D
P
G
F
G
---
F
G
K
-
A
V
V
D
D
N
Y
A
L
L
A
A
L
P
D
T
A
P
A
R
PD
G
----------------
R
A
Y
P
I
L
A
G
M
S
R
K
S
M
L
G
A
V
I
-
G
G
-----
K
P
P
L
-----
E
R
V
A
A
S
V
A
A
A
L
C
A
V
E
R
G
A
A
I
V
R
V
H
D
V
A
A
T
V
D
A
L
S
V
W
N
A
V
R
A
A
A
R
-----
83
HHSearch
76.76
45%
-109
- C6 -
2DQW
-
?
A:
[26-287]
--
L
D
R
V
R
------------
L
L
G
V
L
N
L
T
P
--------------
R
A
L
E
R
A
R
E
M
V
A
-----
E
G
A
D
I
L
D
L
G
A
E
-----------
E
E
E
K
R
R
L
L
P
V
L
E
A
V
L
S
-
L
------
G
-
V
P
V
S
V
D
T
R
K
P
E
V
A
E
E
A
L
K
L
G
A
H
L
L
N
D
V
T
G
L
R
-
D
E
R
M
V
A
L
A
A
R
H
-
G
V
A
A
V
V
M
H
-------
M
P
V
P
D
P
A
T
M
M
-
A
H
A
R
Y
R
----------------------------
D
V
V
A
E
-------------
V
K
A
F
L
E
A
Q
A
R
R
A
L
S
-
A
G
V
P
--
Q
V
V
L
D
P
G
F
G
---
F
G
K
-
L
L
-
E
H
N
L
A
L
L
R
R
L
D
E
I
V
-----
A
----------------
L
G
H
P
V
L
V
G
L
S
R
K
R
T
I
G
E
L
S
-
G
V
-----
E
D
P
A
-----
Q
R
V
H
G
S
V
A
A
H
L
F
A
V
M
K
G
V
R
L
L
R
V
H
D
V
R
A
H
R
E
A
L
G
V
W
E
A
L
Y
G
--------
89
HHSearch
76.69
41%
-96
- C6 -
1AJ0
3
DHPS_ECOLI
A:
[12-280]
--
L
S
H
P
H
------------
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
T
H
N
S
-
L
I
D
A
V
K
H
A
N
L
M
I
N
-----
A
G
A
T
I
I
D
V
G
G
E
S
T
R
P
G
A
A
E
V
S
V
E
E
E
L
Q
R
V
I
P
V
V
E
A
I
A
Q
R
F
------
E
-
V
W
I
S
V
D
T
S
K
P
E
V
I
R
E
S
A
K
V
G
A
H
I
I
N
D
I
R
S
L
S
-
E
P
G
A
L
E
A
A
A
E
T
-
G
L
P
V
C
L
M
H
-------
M
Q
-
G
N
P
K
T
M
Q
-
E
A
P
K
Y
D
----------------------------
D
V
F
A
E
-------------
V
N
R
Y
F
I
E
Q
I
A
R
C
E
Q
-
A
G
I
A
K
E
K
L
L
L
D
P
G
F
G
---
F
G
K
-
N
L
-
S
H
N
Y
S
L
L
A
R
L
A
E
F
H
-----
H
----------------
F
N
L
P
L
L
V
G
M
S
R
K
S
M
I
G
Q
L
L
-
N
------
V
G
P
S
-----
E
R
L
S
G
S
L
A
C
A
V
I
A
A
M
Q
G
A
H
I
I
R
V
H
D
V
K
E
T
V
E
A
M
R
V
V
E
A
T
L
S
A
K
E
N
K
R
--
50
PsiBlast_CBE
76.25
39%
-112
- C6 -
1TX2
6
?
B:
[42-293]
-------------------
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V
-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
69
PsiBlast_CBE
76.09
40%
-116
- C6 -
2Y5J
4
?
A:
[8-292]
--
P
A
P
L
Q
CGRFELTFE
R
P
L
V
M
G
I
L
N
-------------
A
-
R
D
D
A
L
R
R
A
E
R
M
I
A
-----
E
G
A
D
L
L
D
I
G
--------
P
P
V
P
L
D
E
E
L
A
R
V
I
P
L
V
E
A
L
R
P
-
L
------
N
-
V
P
L
S
I
D
T
Y
K
P
A
V
M
R
A
A
L
A
A
G
A
D
L
I
N
D
I
W
G
F
R
-
Q
P
G
A
I
D
A
V
R
D
G
-
N
S
G
L
C
A
M
H
-------
M
L
-
G
E
P
Q
T
M
Q
V
G
E
P
D
Y
G
----------------------------
D
V
V
T
D
-------------
V
R
-
D
F
L
A
A
R
A
Q
A
L
R
D
A
G
V
A
A
E
R
I
C
V
D
P
G
F
G
---
F
G
K
A
V
V
-
D
D
N
Y
A
L
L
A
A
L
P
D
T
A
P
A
R
PD
G
----------------
R
A
Y
P
I
L
A
G
M
S
R
K
S
M
L
G
A
V
I
-
G
G
-----
K
P
P
L
-----
E
R
V
A
A
S
V
A
A
A
L
C
A
V
E
R
G
A
A
I
V
R
V
H
D
V
A
A
T
V
D
A
L
S
V
W
N
A
V
R
A
A
A
R
-----
35
PsiBlast_CBE
76.08
39%
-111
- C6 -
4D8A
5
?
A:
[42-293]
-------------------
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
---------
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V
-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
33
PsiBlast_CBE
75.77
39%
-108
- C6 -
4D8Z
6
?
B:
[42-293]
-------------------
I
M
G
I
L
N
------
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
---------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V
-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
51
PsiBlast_CBE
75.67
39%
-111
- C6 -
1TX0
6
?
B:
[42-293]
-------------------
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V
-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
8
PsiBlast_PDB
75.65
39%
-110
- C6 -
1TX0
6
?
A:
[42-293]
-------------------
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
--------
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V
-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
41
PsiBlast_CBE
75.54
39%
-109
- C6 -
3TYB
5
?
A:
[42-293]
-------------------
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V
-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
11
PsiBlast_PDB
75.50
39%
-114
- C6 -
3H22
5
?
A:
[42-293]
-------------------
I
M
G
I
L
N
V
T
P
D
S
F
--
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V
-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
21
PsiBlast_CBE
75.49
39%
-113
- C6 -
4NL1
5
?
B:
[42-293]
-------------------
I
M
G
I
L
N
V
T
P
--
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
15
PsiBlast_PDB
75.38
39%
-110
- C6 -
3H2A
4
?
A:
[42-293]
-------------------
I
M
G
I
L
N
V
T
P
D
S
F
S
--
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V
-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
39
PsiBlast_CBE
75.29
39%
-106
- C6 -
3TYC
7
?
B:
[42-293]
-------------------
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V
-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
19
PsiBlast_PDB
75.27
39%
-109
- C6 -
3H2N
5
?
A:
[42-293]
-------------------
I
M
G
I
L
N
V
T
P
D
S
F
---
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
R
-----
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V
-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
30
PsiBlast_CBE
75.09
39%
-109
- C6 -
4DAI
5
?
A:
[42-293]
-------------------
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V
-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
44
PsiBlast_CBE
75.05
39%
-106
- C6 -
3H2N
5
?
B:
[42-293]
-------------------
I
M
G
I
L
N
V
T
P
---
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
18
PsiBlast_PDB
74.94
39%
-102
- C6 -
3H2M
5
?
A:
[42-293]
-------------------
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
----
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
2
PsiBlast_PDB
74.85
40%
-96
- C6 -
1AJ0
3
DHPS_ECOLI
A:
[16-280]
------
H
------------
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
T
H
N
S
-
L
I
D
A
V
K
H
A
N
L
M
I
N
-----
A
G
A
T
I
I
D
V
G
G
E
S
T
R
P
G
A
A
E
V
S
V
E
E
E
L
Q
R
V
I
P
V
V
E
A
I
A
Q
-
R
F-----
E
-
V
W
I
S
V
D
T
S
K
P
E
V
I
R
E
S
A
K
V
G
A
H
I
I
N
D
I
R
-
S
L
S
E
P
G
A
L
E
A
A
A
E
T
-
G
L
P
V
C
L
M
H
-------
M
Q
-
G
N
P
K
T
M
Q
E
A
P
-
K
Y
D
----------------------------
D
V
F
A
E
-------------
V
N
R
Y
F
I
E
Q
I
A
R
C
E
Q
-
A
G
I
A
K
E
K
L
L
L
D
P
G
F
G
---
F
G
K
-
N
L
-
S
H
N
Y
S
L
L
A
R
L
A
E
F
H
-----
H
----------------
F
N
L
P
L
L
V
G
M
S
R
K
S
M
I
G
Q
L
L
N
V
G
P
-------
S
-----
E
R
L
S
G
S
L
A
C
A
V
I
A
A
M
Q
G
A
H
I
I
R
V
H
D
V
K
E
T
V
E
A
M
R
V
V
E
A
T
L
S
A
K
E
N
K
R
--
34
PsiBlast_CBE
74.81
39%
-107
- C6 -
4D8Z
5
?
A:
[42-293]
-------------------
I
M
G
I
L
N
-
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
---------
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V
-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
28
PsiBlast_CBE
74.75
39%
-111
- C6 -
4DB7
5
?
A:
[42-293]
-------------------
I
M
G
I
L
N
---
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
6
PsiBlast_PDB
74.71
39%
-104
- C6 -
1TWW
5
?
A:
[42-293]
-------------------
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V
-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
31
PsiBlast_CBE
74.69
39%
-110
- C6 -
4D9P
5
?
B:
[42-293]
-------------------
I
M
G
I
L
N
V
T
-----
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V
-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
10
PsiBlast_PDB
74.45
39%
-108
- C6 -
3H21
4
?
A:
[42-293]
-------------------
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V
-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
38
PsiBlast_CBE
74.41
39%
-108
- C6 -
3TYD
8
?
A:
[42-293]
-------------------
I
M
G
I
L
N
V
T
P
D
S
F
S
--
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V
-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
32
PsiBlast_CBE
74.39
39%
-109
- C6 -
4D9P
5
?
A:
[42-293]
-------------------
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V
-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
17
PsiBlast_PDB
74.33
39%
-103
- C6 -
3H2F
4
?
A:
[42-293]
-------------------
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
-----
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V
-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
47
PsiBlast_CBE
74.32
39%
-113
- C6 -
3H2C
7
?
B:
[42-293]
-------------------
I
M
G
I
L
N
V
T
P
-------
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
--------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
52
PsiBlast_CBE
74.29
39%
-108
- C6 -
1TWZ
5
?
B:
[42-293]
-------------------
I
M
G
I
L
N
V
T
P
D
----
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V
-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
7
PsiBlast_PDB
74.13
39%
-105
- C6 -
1TWZ
5
?
A:
[42-293]
-------------------
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
12
PsiBlast_PDB
73.94
39%
-102
- C6 -
3H23
5
?
A:
[42-293]
-------------------
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V
-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
14
PsiBlast_PDB
73.90
39%
-107
- C6 -
3H26
4
?
A:
[42-293]
-------------------
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V
-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
48
PsiBlast_CBE
73.87
39%
-107
- C6 -
3H2A
5
?
B:
[42-293]
-------------------
I
M
G
I
L
N
V
T
P
-----
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
37
PsiBlast_CBE
73.74
39%
-110
- C6 -
3TYD
7
?
B:
[42-293]
-------------------
I
M
G
I
L
N
V
T
P
D
----
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
-------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
29
PsiBlast_CBE
73.64
39%
-111
- C6 -
4DAI
6
?
B:
[42-293]
-------------------
I
M
G
I
L
N
------
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
-----------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V
-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
43
PsiBlast_CBE
73.55
39%
-108
- C6 -
3TYA
5
?
A:
[42-293]
-------------------
I
M
G
I
L
N
V
T
P
-----
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
----
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V
-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
42
PsiBlast_CBE
73.50
39%
-109
- C6 -
3TYA
7
?
B:
[42-293]
-------------------
I
M
G
I
L
N
V
T
P
D
----
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
--------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V
-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
40
PsiBlast_CBE
73.47
39%
-108
- C6 -
3TYB
7
?
B:
[42-293]
-------------------
I
M
G
I
L
N
V
T
P
D
----
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
--------
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
49
PsiBlast_CBE
73.37
39%
-109
- C6 -
3H24
7
?
B:
[42-293]
-------------------
I
M
G
I
L
N
V
------
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
-------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V
-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
36
PsiBlast_CBE
73.37
39%
-102
- C6 -
3TYE
5
?
A:
[42-293]
-------------------
I
M
G
I
L
N
V
T
P
------
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
R
P
G
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V
-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
58
PsiBlast_CBE
73.01
39%
-93
- C6 -
3TYZ
4
?
B:
[19-279]
------
Q
------------
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
C
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
T
L
I
D
I
G
G
E
S
T
R
P
G
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
A
Q
-
R
F-----
D
-
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
I
R
S
L
Q
-
E
P
G
A
L
E
A
A
A
K
T
-
G
L
P
V
C
L
M
H
-------
M
Q
-
G
Q
P
K
N
M
Q
H
S
P
Y
-
Y
D
----------------------------
D
L
M
T
D
-------------
I
N
R
F
F
Q
H
H
I
E
R
C
V
A
-
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
---
F
G
K
-
N
L
-
A
H
N
Y
Q
L
L
A
H
L
S
E
L
H
-----
H
----------------
F
E
L
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
-
N
------
V
P
P
Q
-----
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
T
R
S
A
K
------
45
PsiBlast_CBE
72.76
39%
-109
- C6 -
3H2M
7
?
B:
[42-293]
-------------------
I
M
G
I
L
N
V
T
P
-----
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
---------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V
-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
9
PsiBlast_PDB
72.71
39%
-102
- C6 -
1TX2
6
?
A:
[42-293]
-------------------
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
----
F
A
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
59
PsiBlast_CBE
72.54
39%
-94
- C6 -
3TYZ
4
?
A:
[19-278]
------
Q
------------
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
C
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
T
L
I
D
I
G
G
E
S
T
R
P
G
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
A
Q
-
R
F-----
D
-
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
I
R
S
L
Q
-
E
P
G
A
L
E
A
A
A
K
T
-
G
L
P
V
C
L
M
H
-------
M
Q
-
G
Q
P
K
N
M
Q
H
S
P
Y
-
Y
D
----------------------------
D
L
M
T
D
-------------
I
N
R
F
F
Q
H
H
I
E
R
C
V
A
-
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
---
F
G
K
-
N
L
-
A
H
N
Y
Q
L
L
A
H
L
S
E
L
H
-----
H
----------------
F
E
L
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
-
N
------
V
P
P
Q
-----
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
T
R
S
A
-------
13
PsiBlast_PDB
72.45
39%
-103
- C6 -
3H24
6
?
A:
[42-293]
-------------------
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
G
E
S
T
------
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V
-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
57
PsiBlast_CBE
72.42
39%
-94
- C6 -
3TZF
2
?
A:
[19-278]
------
Q
------------
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
C
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
T
L
I
D
I
G
G
E
S
T
R
P
G
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
A
Q
-
R
F-----
D
-
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
I
R
S
L
Q
-
E
P
G
A
L
E
A
A
A
K
T
-
G
L
P
V
C
L
M
H
-------
M
Q
-
G
Q
P
K
N
M
Q
H
S
P
Y
-
Y
D
----------------------------
D
L
M
T
D
-------------
I
N
R
F
F
Q
H
H
I
E
R
C
V
A
-
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
---
F
G
K
-
N
L
-
A
H
N
Y
Q
L
L
A
H
L
S
E
L
H
-----
H
----------------
F
E
L
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
-
N
------
V
P
P
Q
-----
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
T
R
S
A
-------
56
PsiBlast_CBE
72.29
39%
-93
- C6 -
3TZF
3
?
B:
[19-279]
------
Q
------------
V
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
C
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
T
L
I
D
I
G
G
E
S
T
R
P
G
--
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
A
Q
-
R
F-----
D
-
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
I
R
S
L
Q
-
E
P
G
A
L
E
A
A
A
K
T
-
G
L
P
V
C
L
M
H
-------
M
Q
-
G
Q
P
K
N
M
Q
H
S
P
Y
-
Y
D
----------------------------
D
L
M
T
D
-------------
I
N
R
F
F
Q
H
H
I
E
R
C
V
A
-
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
---
F
G
K
-
N
L
-
A
H
N
Y
Q
L
L
A
H
L
S
E
L
H
-----
H
----------------
F
E
L
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
-
N
------
V
P
P
Q
-----
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
T
R
S
A
K
------
20
PsiBlast_PDB
71.41
39%
-107
- C6 -
3H2O
3
?
A:
[42-293]
-------------------
I
M
G
I
L
N
V
T
P
D
S
F
S
D
G
G
S
Y
N
E
-
V
D
A
A
V
R
H
A
K
E
M
R
D
-----
E
G
A
H
I
I
D
I
G
---------
K
V
S
V
E
E
E
I
K
R
V
V
P
M
I
Q
A
V
S
K
-
E
V
-----
K
-
L
P
I
S
I
D
T
Y
K
A
E
V
A
K
Q
A
I
E
A
G
A
H
I
I
N
D
I
W
G
A
K
A
E
P
K
I
A
E
V
A
A
H
Y
-
D
V
P
I
I
L
M
H
-------
N
R
-
D
--------
N
M
N
Y
R
----------------------------
N
L
M
A
D
-------------
M
I
A
D
L
Y
D
S
I
K
I
A
K
D
-
A
G
V
R
D
E
N
I
I
L
D
P
G
I
G
---
F
A
K
-
T
P
-
E
Q
N
L
E
A
M
R
N
L
E
Q
L
N
-----
V
----------------
L
G
Y
P
V
L
L
G
T
S
R
K
S
F
I
G
H
V
L
-
D
------
L
P
V
E
-----
E
R
L
E
G
T
G
A
T
V
C
L
G
I
E
K
G
C
E
F
V
R
V
H
D
V
K
E
M
S
R
M
A
K
M
M
D
A
M
I
G
--------
61
PsiBlast_CBE
71.30
44%
-112
- C6 -
2DZB
1
?
B:
[29-286]
-----
V
R
------------
L
L
G
V
L
N
L
T
P
D
-----------
P
E
R
A
L
E
R
A
R
E
M
V
A
-----
E
G
A
D
I
L
D
L
G
A
E
S
T
-------
P
V
E
E
E
K
R
R
L
L
P
V
L
E
A
V
L
S
-
L
------
G
-
V
P
V
S
V
D
T
R
K
P
E
V
A
E
E
A
L
K
L
G
A
H
L
L
N
D
V
T
G
L
R
-
D
E
R
M
V
A
L
A
A
R
H
-
G
V
A
A
V
V
M
H
-------
M
P
---------
A
H
A
R
Y
R
----------------------------
D
V
V
A
E
-------------
V
K
A
F
L
E
A
Q
A
R
R
A
L
S
-
A
G
V
--
P
Q
V
V
L
D
P
G
F
G
---
F
G
K
-
L
L
-
E
H
N
L
A
L
L
R
R
L
D
E
I
V
-----
A
----------------
L
G
H
P
V
L
V
G
L
S
R
K
R
T
I
G
E
L
-----
S
G
V
E
D
P
A
Q
------
R
V
H
G
S
V
A
A
H
L
F
A
V
M
K
G
V
R
L
L
R
V
H
D
V
R
A
H
R
E
A
L
G
V
W
E
A
L
Y
---------
70
PsiBlast_CBE
70.65
34%
-108
- C6 -
2VEG
2
DHPS_STRR6
A:
[12-303]
-------------------
I
C
G
I
I
N
V
T
P
---------
F
A
-
L
E
Q
A
L
Q
Q
A
R
K
L
I
A
-----
E
G
A
S
M
L
D
I
G
G
E
-----
S
S
Y
V
E
I
E
E
E
I
Q
R
V
V
P
V
I
K
A
I
R
K
-
E
------
S
D
V
L
I
S
I
D
T
W
K
S
Q
V
A
E
A
A
L
A
A
G
A
D
L
V
N
D
I
T
G
L
M
G
D
E
K
M
P
H
V
V
A
E
A
-
R
A
Q
V
V
I
M
F
N
P
V
M
A
R
P
Q
H
-
P
S
S
L
I
F
P
H
F
G
--
F
------------------------------
A
F
T
-EL
A
D
F
E
T
LP
I
E
E
L
M
E
A
F
F
E
R
A
L
A
R
A
A
E
-
A
G
I
A
P
E
N
I
L
L
D
P
G
I
G
---
F
G
L
-
T
K
-
K
E
N
L
L
L
L
R
D
L
D
K
L
H
-----
Q
----------------
K
G
Y
P
I
F
L
G
V
S
R
K
R
F
V
I
N
I
L
-
E
E
N
G
F
E
V
N
P
E
T
E
L
G
F
R
N
R
D
T
A
S
A
H
V
T
S
I
A
A
R
Q
G
V
E
V
V
R
V
H
D
V
A
S
H
R
M
A
V
E
I
A
S
A
I
R
L
A
D
------
93
HHSearch
69.22
32%
-92
- C6 -
3TR9
4
?
A:
[25-293]
--
F
S
E
P
A
------------
V
M
G
I
I
N
V
S
P
N
S
F
Y
H
P
H
L
--
D
-
L
N
S
A
L
R
T
A
E
K
M
V
D
-----
E
G
A
D
I
L
D
I
G
G
E
A
T
N
P
F
V
-
S
P
S
T
Q
I
E
L
D
R
L
L
P
V
I
D
A
I
K
K
-
R
F-----
P
-
Q
L
I
S
V
D
T
S
R
P
R
V
M
R
E
A
V
N
T
G
A
D
M
I
N
D
Q
R
A
L
Q
L
-
D
D
A
L
T
T
V
S
A
L
-
K
T
P
V
C
L
M
H
-------
F
P
-
S
E
T
R
K
P
G
-
S
T
T
H
F
-----------------------------
Y
F
L
Q
S
-------------
V
K
K
E
L
Q
E
S
I
Q
R
C
K
K
-
A
G
I
S
E
D
R
I
I
I
D
P
G
F
G
Q
GN
Y
G
K
-
N
V
-
S
E
N
F
Y
L
L
N
K
L
P
E
F
V
-----
A
----------------
M
G
L
P
V
L
S
G
W
S
R
K
S
M
I
G
D
V
L
-
N
------
Q
P
P
E
-----
N
R
L
F
G
S
I
A
A
D
V
L
A
V
Y
H
G
A
S
I
I
R
T
H
D
V
K
A
T
R
E
A
I
K
I
A
T
Y
T
R
S
V
D
------
60
PsiBlast_CBE
68.97
39%
-95
- C6 -
3TYU
1
?
A:
[19-278]
------
Q
------------
V
M
G
I
L
N
V
T
P
D
S
------
H
N
N
-
L
D
Q
A
L
Q
H
A
Q
R
M
L
S
-----
A
G
A
T
L
I
D
I
G
G
E
S
T
R
P
G
A
A
E
V
S
E
Q
E
E
L
D
R
V
V
P
V
V
E
A
L
A
Q
-
R
F-----
D
-
V
W
L
S
V
D
T
S
K
A
A
V
I
T
E
S
A
H
A
G
A
H
L
I
N
D
I
R
S
L
Q
-
E
P
G
A
L
E
A
A
A
K
T
-
G
L
P
V
C
L
M
H
-------
M
Q
-
G
----
M
Q
H
S
P
Y
-
Y
D
----------------------------
D
L
M
T
D
-------------
I
N
R
F
F
Q
H
H
I
E
R
C
V
A
-
A
G
I
A
K
N
K
L
L
L
D
P
G
F
G
---
F
G
K
-
N
L
-
A
H
N
Y
Q
L
L
A
H
L
S
E
L
H
-----
H
----------------
F
E
L
P
L
L
V
G
M
S
R
K
S
M
V
G
Q
L
L
-
N
------
V
P
P
Q
-----
Q
R
V
I
G
S
V
A
C
A
V
I
A
A
M
Q
G
A
Q
I
I
R
V
H
D
V
K
E
T
V
E
A
M
C
I
V
E
A
T
R
S
A
-------
84
HHSearch
68.54
33%
-92
- C6 -
2BMB
1
FOL1_YEAST
A:
[223-543]
---
S
P
T
Y
------------
I
M
A
I
F
N
A
T
P
D
S
F
S
D
G
G
E
H
F
A
D
I
E
S
Q
L
N
D
I
I
K
L
C
K
D
A
L
YL
H
E
S
V
I
I
D
V
G
G
C
S
T
R
P
N
S
I
Q
A
S
E
E
E
E
I
R
R
S
I
P
L
I
K
A
I
R
E
-
S
TELPQD
K
-
V
I
L
S
I
D
T
Y
R
S
N
V
A
K
E
A
I
K
V
G
V
D
I
I
N
D
I
S
G
G
L
F
D
S
N
M
F
A
V
I
A
E
N
P
E
I
C
Y
I
L
S
H
-------
T
R
-
G
D
I
S
T
M
N
-
R
L
A
H
Y
E
NFALGDSIQ
Q
E
F
V
HNTDIQQLDD
L
K
D
K
T
V
L
I
R
N
-------------
V
G
Q
E
I
G
E
R
Y
I
K
A
I
D
-
N
G
V
K
R
W
Q
I
L
I
D
P
G
L
G
---
F
A
K
-
T
W
-
K
Q
N
L
Q
I
I
R
H
I
P
I
L
K
-----
N
Y
S
F
T
M
N
S
NN
S
Q
V
Y
V
N
L
R
N
M
P
V
L
L
G
P
S
R
K
K
F
I
G
H
I
T
-
K
D
-----
V
D
A
K
-----
Q
R
D
F
A
T
G
A
V
V
A
S
C
I
G
F
G
S
D
M
V
R
V
H
D
V
K
N
C
S
K
S
I
K
L
A
D
A
I
Y
K
G
-------