@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3610c: (2016-05-21 )
MNRKNVTRTITAIAVVVLLGWSFFYFSDDTRGYKPVDTSVAITQINGDNVKSAQIDDREQQLRLILKKGNNETDGSEKVITKYPTGYAVDLFNALSAKNAKVSTVVNQGSILGELLVYVLPLLLLVGLFVMFSRMQGGARMGFGFGKSRAKQLSKDMPKTTFADVAGVDEAVEELYEIKDFLQNPSRYQALGAKIPKGVLLYGPPGTGKTLLARAVAGEAGVPFFTISGSDFVEMFVGVGASRVRDLFEQAKQNSPCIIFVDEIDAVGRQRGAGLGGGHDEREQTLNQLLVEMDGFGDRAGVILIAATNRPDILDPALLRPGRFDRQIPVSNPDLAGRRAVLRVHSKGKPMAADADLDGLAKRTVGMTGADLANVINEAALLTARENGTVITGPALEEAVDRVIGGPRRKGRIISEQEKKITAYHEGGHTLAAWAMPDIEPIYKVTILARGRTGGHAVAVPEEDKGLRTRSEMIAQLVFAMGGRAAEELVFREPTTGAVSDIEQATKIARSMVTEFGMSSKLGAVKYGSEHGDPFLGRTMGTQPDYSHEVAREIDEEVRKLIEAAHTEAWEILTEYRDVLDTLAGELLEKETLHRPELESIFADVEKRPRLTMFDDFGGRIPSDKPPIKTPGELAIERGEPWPQPVPEPAFKAAIAQATQAAEAARSDAGQTGHGANGSPAGTHRSGDRQYGSTQPDYGAPAGWHAPGWPPRSSHRPSYSGEPAPTYPGQPYPTGQADPGSDESSAEQDDEVSRTKPAHG
Atome Classification :
(41 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150....-...160.......170.......180........190.......200.......210.......220........230.......240.......250.......260.......270.......280.......290.....-.-.300.......310.......320.......330.......340.......350--.....--..360.......370.......380.......-----------------390.......400.......410.......420.......430.......440.......450........460.......470.......480.......490.--.--.....500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740.......750.......760
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNR
K
N
V
T
R
T
I
T
A
I
A
V
V
V
L
LG
W
S
F
F
Y
FSDDTRGYKPVD
T
S
V
A
I
T
Q
INGDNVKSAQID
D
R
E
Q
Q
L
R
L
I
LKKGNNETDGSE
K
V
I
T
KYPTG
Y
A
V
D
L
F
N
A
L
SAKNA
K
V
S
T
V
VN
Q
G
S
I
L
G
E
L
L
V
Y
V
L
P
L
L
L
L
V
G
L
F
V
M
F
S
R
MQGGARMGFGF
G
K
S
R
A
K
Q
L
S
K
D-MPK
T
T
F
A
D
VA
G
V
D
E
A
V
E
E
L
Y
E
I
K
D
F
-LQNP
S
R
Y
Q
A
L
GAKIPK
G
V
L
L
YGPPGT
G
K
T
L
L
A
R
A
VAGEA-GV
P
F
F
T
ISG
S
D
F
V
E
M
F
V
GV
G
A
S
R
V
R
D
L
F
E
Q
AKQNS
P
C
I
I
F
VDE
I
D
AVGRQRGAGLGGG
H
D
E
R
E
Q
T
L
N
Q
L
L
V
E
MDGFG-D-RA
G
V
I
L
I
A
ATNRPDIL
D
P
A
LLRPGRFDRQIPVSNPDLAG
R
R
A
V
L
R
VHSKGKPMA--ADA
D
L
--
D
G
L
A
K
R
TVGM
T
G
A
D
L
A
N
V
I
N
E
A
A
L
L
TAREN
G
T
-----------------
V
I
T
G
P
A
L
E
E
A
V
D
R
V
IGGPRRKGRII
S
E
QE
K
K
I
T
A
Y
HEGG
H
T
L
A
A
WAMPDIE
P
I
Y
K
V
T
I
L
A
RG-RTGG
H
A
V
AVPEEDKG
L
R
T
R
S
E
M
I
A
Q
L
V
F
A
MGG
R
A
A
E
E
L
V
FRE--P--TTG
A
V
S
D
I
E
Q
A
T
K
I
A
R
S
M
V
T
EFGMSSKL
G
A
V
K
YGSEHGDPFLGRTMGTQPD
Y
S
H
E
V
A
R
E
I
D
E
E
V
R
K
L
I
E
A
AH
T
E
A
W
E
I
L
T
E
Y
R
D
V
L
D
T
L
A
G
E
L
L
E
K
ETLH
R
P
E
L
E
S
I
F
A
D
V
E
KRPR
L
T
M
FDDFGGRIPSDKPPIKTPG
E
L
A
IERGEPWPQPVP
E
P
A
F
K
A
A
I
A
Q
A
T
Q
A
A
E
A
A
RSDAGQTGHGANGSPAGTHRSGDRQYGSTQPDYGAPAGWHAPGWPPRSSHRPSYSGEPAPTYPGQPYPTGQADPGSDESSAEQDDEVSRTKPAHG
1
PsiBlast_PDB
92.50
57%
-90
- C1 -
3KDS
2
FTSH_THEMA
E:
[12-458]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
F
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
-
L
K
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
I
L
L
V
G
P
P
G
T
G
A
T
L
L
A
R
A
V
A
G
E
A
-
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
H
---------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
-
S
-
K
E
G
I
I
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
N
K
P
L
A
--
E
D
V
N
L
--
E
I
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
G
R
D
-----------------
K
I
T
M
K
D
F
E
E
A
I
D
R
V
I
A
G
P
A
R
K
S
L
L
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
P
R
G
Y
K
A
L
G
Y
T
L
H
L
P
E
E
D
K
Y
L
V
S
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
G
D
--
V
--
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
L
G
P
L
A
W
G
K
------------
R
L
R
N
Y
S
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
S
E
------------------------------------------------------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
90.33
57%
-95
- C1 -
2CE7
1
FTSH_THEMA
D:
[12-458]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
F
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
-
L
K
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
I
L
L
V
G
P
P
G
T
G
K
T
L
L
A
R
A
V
A
G
E
A
-
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
------------
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
-
S
-
K
E
G
I
I
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
N
K
P
L
A
--
E
D
V
N
L
--
E
I
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
G
R
D
-----------------
K
I
T
M
K
D
F
E
E
A
I
D
R
V
I
A
----
K
S
L
L
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
P
R
G
Y--------------
Y
L
V
S
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
G
D
--
V
--
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
L
G
P
L
A
W
G
--------------
L
R
N
Y
S
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
S
E
------------------------------------------------------------------------------------------------------------------------------------------------------------
101
Fugue
90.08
57%
-92
- C1 -
2CE7
1
FTSH_THEMA
A:
[5-457]
-------------------------------------------------------------------------------------------------------------------------------------------------------
Y
K
P
S
G
-
N
K
R
V
T
F
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
-
L
K
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
I
L
L
V
G
P
P
G
T
G
K
T
L
L
A
R
A
V
A
G
E
A
-
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
---------
H
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
-
S
-
K
E
G
I
I
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
N
K
P
L
A
--
E
D
V
N
L
--
E
I
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
G
R
D
-----------------
K
I
T
M
K
D
F
E
E
A
I
D
R
V
I
--------
L
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
K
Y
L
-
V
S
----------------
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
G
D
--
V
--
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
L
G
P
L
A
W
G
K
L
R
-------------
N
Y
S
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
S
-------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
90.02
57%
-96
- C1 -
2CEA
1
FTSH_THEMA
D:
[12-458]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
F
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
-
L
K
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
I
L
L
V
G
P
P
G
T
G
K
T
L
L
A
R
A
V
A
G
E
A
-
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
------------
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
-
S
-
K
E
G
I
I
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
N
K
P
L
A
--
E
D
V
N
L
--
E
I
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
G
R
D
-----------------
K
I
T
M
K
D
F
E
E
A
I
D
R
V
I
A
----
K
S
L
L
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
P
R
G
Y--------------
Y
L
V
S
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
G
D
--
V
--
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
L
G
P
L
A
W
G
--------------
L
R
N
Y
S
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
S
E
------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
89.81
57%
-93
- C1 -
2CEA
2
FTSH_THEMA
C:
[12-458]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
F
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
-
L
K
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
I
L
L
V
G
P
P
G
T
G
K
T
L
L
A
R
A
V
A
G
E
A
-
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
-------------
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
-
S
-
K
E
G
I
I
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
N
K
P
L
A
--
E
D
V
N
L
--
E
I
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
G
R
D
-----------------
K
I
T
M
K
D
F
E
E
A
I
D
R
V
I
--------
L
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
P
R
G
Y
K
A
L
G
Y
T
L
H
L
P
E
E
D
K
Y
L
V
S
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
G
D
--
V
--
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
L
G
P
L
A
W
G
---------------
R
N
Y
S
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
S
E
------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
89.52
57%
-90
- C1 -
2CE7
2
FTSH_THEMA
C:
[12-458]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
F
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
-
L
K
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
I
L
L
V
G
P
P
G
T
G
K
T
L
L
A
R
A
V
A
G
E
A
-
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
-------------
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
-
S
-
K
E
G
I
I
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
N
K
P
L
A
--
E
D
V
N
L
--
E
I
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
G
R
D
-----------------
K
I
T
M
K
D
F
E
E
A
I
D
R
V
I
--------
L
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
P
R
G
Y
K
A
L
G
Y
T
L
H
L
P
E
E
D
K
Y
L
V
S
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
G
D
--
V
--
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
L
G
P
L
A
W
G
---------------
R
N
Y
S
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
S
E
------------------------------------------------------------------------------------------------------------------------------------------------------------
112
HHSearch
89.30
53%
-95
- C1 -
4WW0
2
FTSH_AQUAE
A:
[7-464]
-------------------------------------------------------------------------------------------------------------------------------------------------------
V
Y
I
E
E
-
K
P
K
V
T
F
K
D
V
A
G
I
E
E
V
K
E
E
V
K
E
I
I
E
Y
-
L
K
D
P
V
K
F
Q
K
L
G
G
R
P
P
K
G
V
L
L
Y
G
E
P
G
V
G
K
T
L
L
A
K
A
I
A
G
E
A
-
H
V
P
F
I
S
V
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
K
H
A
P
C
M
I
F
I
D
E
I
D
A
V
G
R
-----------
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
-
T
-
S
D
G
I
I
V
I
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
F
I
P
K
P
D
V
R
G
R
Y
E
I
L
K
V
H
A
R
N
K
K
L
A
--
K
D
V
D
L
--
E
F
V
A
R
A
T
P
G
L
T
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
K
G
K
E
-----------------
E
I
T
M
E
E
I
E
E
A
L
D
R
I
T
M
-------
T
I
S
P
K
E
K
E
K
I
A
I
H
E
A
G
H
A
L
M
G
L
V
S
D
D
D
D
K
V
H
K
I
S
I
I
P
-----------------
H
I
Y
D
K
K
D
L
Y
N
K
I
L
V
L
L
G
G
R
A
A
E
E
V
F
F
G
K
DG
I
--
T
T
G
A
E
N
D
L
Q
R
A
T
D
L
A
Y
R
M
V
S
M
W
G
M
S
D
K
V
G
P
I
A
I
R
R
---------------
D
T
S
P
D
L
L
R
E
I
D
E
E
V
R
R
I
I
T
E
Q
Y
E
K
A
K
A
I
V
E
E
Y
K
E
P
L
K
A
V
V
K
K
L
L
E
K
E
T
I
T
C
E
E
F
V
E
V
F
K
L
Y
G
I
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
89.05
57%
-92
- C1 -
2CE7
11
FTSH_THEMA
F:
[12-458]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
F
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
-
L
K
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
I
L
L
V
G
P
P
G
T
G
K
T
L
L
A
R
A
V
A
G
E
A
-
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
----------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
-
S
-
K
E
G
I
I
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
N
K
P
L
A
--
E
D
V
N
L
--
E
I
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
G
R
D
-----------------
K
I
T
M
K
D
F
E
E
A
I
D
R
V
I
---------
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
P
R
G
Y
K
A
L
G
----------
Y
L
V
S
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
G
D
--
V
--
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
L
G
P
L
A
W
G
---------------
R
N
Y
S
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
S
E
------------------------------------------------------------------------------------------------------------------------------------------------------------
28
PsiBlast_CBE
88.23
57%
-83
- C1 -
2DHR
1
FTSH_THET8
E:
[18-465]
----------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
V
L
T
-
E
-
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
-
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
-
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
--
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
-----------------
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
-
R
A
L
G
F
M
M
P
-
R
R
E
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
--
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
A
V
R
E
-
D
T
Y
L
G
G
Y
D
V
R
Q
--
Y
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
88.14
57%
-95
- C1 -
2CEA
11
FTSH_THEMA
F:
[12-458]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
T
F
K
D
V
G
G
A
E
E
A
I
E
E
L
K
E
V
V
E
F
-
L
K
D
P
S
K
F
N
R
I
G
A
R
M
P
K
G
I
L
L
V
G
P
P
G
T
G
K
T
L
L
A
R
A
V
A
G
E
A
-
N
V
P
F
F
H
I
S
G
S
D
F
V
E
L
F
V
G
V
G
A
A
R
V
R
D
L
F
A
Q
A
K
A
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
----------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
-
S
-
K
E
G
I
I
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
K
K
I
V
V
D
P
P
D
M
L
G
R
K
K
I
L
E
I
H
T
R
N
K
P
L
A
--
E
D
V
N
L
--
E
I
I
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
V
N
E
A
A
L
L
A
A
R
E
G
R
D
-----------------
K
I
T
M
K
D
F
E
E
A
I
D
R
V
I
---------
I
S
P
A
E
K
R
I
I
A
Y
H
E
A
G
H
A
V
V
S
T
V
V
P
N
G
E
P
V
H
R
I
S
I
I
P
R
G
Y
K
A
L
G
----------
Y
L
V
S
R
N
E
L
L
D
K
L
T
A
L
L
G
G
R
A
A
E
E
V
V
F
G
D
--
V
--
T
S
G
A
A
N
D
I
E
R
A
T
E
I
A
R
N
M
V
C
Q
L
G
M
S
E
E
L
G
P
L
A
W
G
---------------
R
N
Y
S
E
E
V
A
S
K
I
D
E
E
V
K
K
I
V
T
N
C
Y
E
R
A
K
E
I
I
R
K
Y
R
K
Q
L
D
N
I
V
E
I
L
L
E
K
E
T
I
E
G
D
E
L
R
R
I
L
S
E
------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
88.04
52%
-96
- C1 -
4WW0
2
FTSH_AQUAE
A:
[4-458]
----------------------------------------------------------------------------------------------------------------------------------------------------
M
A
K
V
Y
I
E
E
-
K
P
K
V
T
F
K
D
V
A
G
I
E
E
V
K
E
E
V
K
E
I
I
E
Y
-
L
K
D
P
V
K
F
Q
K
L
G
G
R
P
P
K
G
V
L
L
Y
G
E
P
G
V
G
K
T
L
L
A
K
A
I
A
G
E
A
-
H
V
P
F
I
S
V
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
K
H
A
P
C
M
I
F
I
D
E
I
D
A
V
G
R
-----------
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
-
T
-
S
D
G
I
I
V
I
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
F
I
P
K
P
D
V
R
G
R
Y
E
I
L
K
V
H
A
R
N
K
K
L
A
--
K
D
V
D
L
--
E
F
V
A
R
A
T
P
G
L
T
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
K
G
K
E
-----------------
E
I
T
M
E
E
I
E
E
A
L
D
R
I
T
M
-------
T
I
S
P
K
E
K
E
K
I
A
I
H
E
A
G
H
A
L
M
G
L
V
S
D
D
D
D
K
V
H
K
I
S
I
I
P
-----------------
H
I
Y
D
K
K
D
L
Y
N
K
I
L
V
L
L
G
G
R
A
A
E
E
V
F
F
G
K
--
D
GI
T
T
G
A
E
N
D
L
Q
R
A
T
D
L
A
Y
R
M
V
S
M
W
G
M
S
D
K
V
G
P
I
A
I
-
R
R
--------------
D
T
S
P
D
L
L
R
E
I
D
E
E
V
R
R
I
I
T
E
Q
Y
E
K
A
K
A
I
V
E
E
Y
K
E
P
L
K
A
V
V
K
K
L
L
E
K
E
T
I
T
C
E
E
F
V
E
V
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------
113
HHSearch
87.63
56%
-83
- C1 -
2DHR
1
FTSH_THET8
A:
[25-472]
-------------------------------------------------------------------------------------------------------------------------------------------------------------
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
-
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
-
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
--
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
-----------------
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
-
R
A
L
G
F
M
M
P
R
R
E
-
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
--
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
A
V
R
E
D
T
Y
L
G
G
---
Y
D
V
R
Q
Y
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
V
E
G
L
P
L
E
--------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
87.37
57%
-83
- C1 -
2DHR
1
FTSH_THET8
A:
[18-465]
----------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
V
L
T
-
E
-
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
-
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
-
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
--
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
-----------------
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
-
R
A
L
G
F
M
M
P
-
R
R
E
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
--
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
A
V
R
E
-
D
T
Y
L
G
G
Y
D
V
R
Q
--
Y
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------
30
PsiBlast_CBE
87.10
57%
-81
- C1 -
2DHR
1
FTSH_THET8
C:
[18-465]
----------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
V
L
T
-
E
-
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
-
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
-
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
--
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
-----------------
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
-
R
A
L
G
F
M
M
P
-
R
R
E
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
--
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
A
V
R
E
-
D
T
Y
L
G
G
Y
D
V
R
Q
--
Y
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------
39
PsiBlast_CBE
87.02
52%
-95
- C1 -
4WW0
3
FTSH_AQUAE
C:
[9-458]
---------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
E
-
K
P
K
V
T
F
K
D
V
A
G
I
E
E
V
K
E
E
V
K
E
I
I
E
Y
-
L
K
D
P
V
K
F
Q
K
L
G
G
R
P
P
K
G
V
L
L
Y
G
E
P
G
V
G
K
T
L
L
A
K
A
I
A
G
E
A
-
H
V
P
F
I
S
V
S
G
S
D
----
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
K
H
A
P
C
M
I
F
I
D
E
I
D
A
V
G
R
----------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
-
T
-
S
D
G
I
I
V
I
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
F
I
P
K
P
D
V
R
G
R
Y
E
I
L
K
V
H
A
R
N
K
K
L
A
--
K
D
V
D
L
--
E
F
V
A
R
A
T
P
G
L
T
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
K
G
K
E
-----------------
E
I
T
M
E
E
I
E
E
A
L
D
R
---------
M
T
I
S
P
K
E
K
E
K
I
A
I
H
E
A
G
H
A
L
M
G
L
V
S
D
D
D
D
K
V
H
K
I
S
I
I
P
---------------
D
K
H
I
Y
D
K
K
D
L
Y
N
K
I
L
V
L
L
G
G
R
A
A
E
E
V
F
F
G
K
--
D
GI
T
T
G
A
E
N
D
L
Q
R
A
T
D
L
A
Y
R
M
V
S
M
W
G
M
S
D
K
V
G
P
I
A
I
-
R
-------------
A
V
D
T
S
P
D
L
L
R
E
I
D
E
E
V
R
R
I
I
T
E
Q
Y
E
K
A
K
A
I
V
E
E
Y
K
E
P
L
K
A
V
V
K
K
L
L
E
K
E
T
I
T
C
E
E
F
V
E
V
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
86.43
52%
-93
- C1 -
4Z8X
3
FTSH_AQUAE
A:
[5-458]
-----------------------------------------------------------------------------------------------------------------------------------------------------
A
K
V
Y
I
E
E
-
K
P
K
V
T
F
K
D
V
A
G
I
E
E
V
K
E
E
V
K
E
I
I
E
Y
-
L
K
D
P
V
K
F
Q
K
L
G
G
R
P
P
K
G
V
L
L
Y
G
E
P
G
V
G
K
T
L
L
A
K
A
I
A
G
E
A
-
H
V
P
F
I
S
V
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
K
H
A
P
C
M
I
F
I
D
E
I
D
A
V
G
R
----------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
-
T
-
S
D
G
I
I
V
I
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
F
I
P
K
P
D
V
R
G
R
Y
E
I
L
K
V
H
A
R
N
K
K
L
A
--
K
D
V
D
L
--
E
F
V
A
R
A
T
P
G
L
T
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
K
G
K
E
-----------------
E
I
T
M
E
E
I
E
E
A
L
D
R
I
T
M
-------
T
I
S
P
K
E
K
E
K
I
A
I
H
E
A
G
H
A
L
M
G
L
V
S
D
D
D
D
K
V
H
K
I
S
I
I
P
------------
P
I
E
D
K
H
I
Y
D
K
K
D
L
Y
N
K
I
L
V
L
L
G
G
R
A
A
E
E
V
F
F
G
K
--
D
GI
T
T
G
A
E
N
D
L
Q
R
A
T
D
L
A
Y
R
M
V
S
M
W
G
M
S
D
K
V
G
P
I
A
I
-
R
R
--------------
D
T
S
P
D
L
L
R
E
I
D
E
E
V
R
R
I
I
T
E
Q
Y
E
K
A
K
A
I
V
E
E
Y
K
E
P
L
K
A
V
V
K
K
L
L
E
K
E
T
I
T
C
E
E
F
V
E
V
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------
33
PsiBlast_CBE
86.22
57%
-80
- C1 -
4EIW
1
FTSH_THET8
E:
[27-474]
----------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
V
L
T
-
E
-
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
-
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
-
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
--
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
-----------------
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
-
R
A
L
G
F
M
M
P
-
R
R
E
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
--
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
A
V
R
E
-
D
T
Y
L
G
G
Y
D
V
R
Q
--
Y
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------
31
PsiBlast_CBE
86.05
57%
-85
- C1 -
2DHR
1
FTSH_THET8
B:
[22-465]
--------------------------------------------------------------------------------------------------------------------------------------------------------
L
T
-
E
-
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
-
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
--------
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
-
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
--
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
-----------------
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
-
R
A
L
G
F
M
M
P
-
R
R
E
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
--
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
A
V
R
E
-
D
T
Y
L
G
G
Y
D
V
R
Q
--
Y
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------
38
PsiBlast_CBE
86.03
52%
-94
- C1 -
4Z8X
2
FTSH_AQUAE
B:
[5-458]
-----------------------------------------------------------------------------------------------------------------------------------------------------
A
K
V
Y
I
E
E
-
K
P
K
V
T
F
K
D
V
A
G
I
E
E
V
K
E
E
V
K
E
I
I
E
Y
-
L
K
D
P
V
K
F
Q
K
L
G
G
R
P
P
K
G
V
L
L
Y
G
E
P
G
V
G
K
T
L
L
A
K
A
I
A
G
E
A
-
H
V
P
F
I
S
V
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
K
H
A
P
C
M
I
F
I
D
E
I
D
A
V
G
R
----------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
-
T
-
S
D
G
I
I
V
I
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
F
I
P
K
P
D
V
R
G
R
Y
E
I
L
K
V
H
A
R
N
K
K
L
A
--
K
D
V
D
L
--
E
F
V
A
R
A
T
P
G
L
T
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
K
G
K
E
-----------------
E
I
T
M
E
E
I
E
E
A
L
D
R
I
T
M
-------
T
I
S
P
K
E
K
E
K
I
A
I
H
E
A
G
H
A
L
M
G
L
V
S
D
D
D
D
K
V
H
K
I
S
I
I
P
------------
P
I
E
D
K
H
I
Y
D
K
K
D
L
Y
N
K
I
L
V
L
L
G
G
R
A
A
E
E
V
F
F
G
K
--
D
GI
T
T
G
A
E
N
D
L
Q
R
A
T
D
L
A
Y
R
M
V
S
M
W
G
M
S
D
K
V
G
P
I
A
I
-
R
R
--------------
D
T
S
P
D
L
L
R
E
I
D
E
E
V
R
R
I
I
T
E
Q
Y
E
K
A
K
A
I
V
E
E
Y
K
E
P
L
K
A
V
V
K
K
L
L
E
K
E
T
I
T
C
E
E
F
V
E
V
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
86.01
57%
-78
- C1 -
4EIW
1
FTSH_THET8
A:
[27-474]
----------------------------------------------------------------------------------------------------------------------------------------------------
R
A
R
V
L
T
-
E
-
A
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
-
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
G
S
G
V
G
G
G
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
-
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
--
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
-----------------
K
I
T
M
K
D
L
E
E
A
A
D
R
V
M
M
L
P
A
K
K
S
L
V
L
S
P
R
D
R
R
I
T
A
Y
H
E
A
G
H
A
L
A
A
H
F
L
E
H
A
D
G
V
H
K
V
T
I
V
P
R
G
-
R
A
L
G
F
M
M
P
-
R
R
E
D
M
L
H
W
S
R
K
R
L
L
D
Q
I
A
V
A
L
A
G
R
A
A
E
E
I
V
F
D
D
--
V
--
T
T
G
A
E
N
D
F
R
Q
A
T
E
L
A
R
R
M
I
T
E
W
G
M
H
P
E
F
G
P
V
A
Y
A
V
R
E
-
D
T
Y
L
G
G
Y
D
V
R
Q
--
Y
S
E
E
T
A
K
R
I
D
E
A
V
R
R
L
I
E
E
Q
Y
Q
R
V
K
A
L
L
L
E
K
R
E
V
L
E
R
V
A
E
T
L
L
E
R
E
T
L
T
A
E
E
F
Q
R
V
---------------------------------------------------------------------------------------------------------------------------------------------------------------
40
PsiBlast_CBE
85.16
52%
-89
- C1 -
4WW0
2
FTSH_AQUAE
B:
[3-458]
---------------------------------------------------------------------------------------------------------------------------------------------------
H
M
A
K
V
Y
I
E
---
P
K
V
T
F
K
D
V
A
G
I
E
E
V
K
E
E
V
K
E
I
I
E
Y
-
L
K
D
P
V
K
F
Q
K
L
G
G
R
P
P
K
G
V
L
L
Y
G
E
P
G
V
G
K
T
L
L
A
K
A
I
A
G
E
A
-
H
V
P
F
I
S
V
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
K
H
A
P
C
M
I
F
I
D
E
I
D
A
V
G
R
----------
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
D
-
T
-
S
D
G
I
I
V
I
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
F
I
P
K
P
D
V
R
G
R
Y
E
I
L
K
V
H
A
R
N
K
K
L
A
--
K
D
V
D
L
--
E
F
V
A
R
A
T
P
G
L
T
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
K
G
K
E
-----------------
E
I
T
M
E
E
I
E
E
A
L
D
R
I
--------
M
T
I
S
P
K
E
K
E
K
I
A
I
H
E
A
G
H
A
L
M
G
L
V
S
D
D
D
D
K
V
H
K
I
S
I
I
P
R
G
-
M
A
L
--------
E
D
K
H
I
Y
D
K
K
D
L
Y
N
K
I
L
V
L
L
G
G
R
A
A
E
E
V
F
F
G
K
--
D
GI
T
T
G
A
E
N
D
L
Q
R
A
T
D
L
A
Y
R
M
V
S
M
W
G
M
S
D
K
V
G
P
I
A
I
-
R
---------------
D
T
S
P
D
L
L
R
E
I
D
E
E
V
R
R
I
I
T
E
Q
Y
E
K
A
K
A
I
V
E
E
Y
K
E
P
L
K
A
V
V
K
K
L
L
E
K
E
T
I
T
C
E
E
F
V
E
V
F
--------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
70.47
70%
-92
- C1 -
1IY1
1
FTSH_THET8
A:
[12-252]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
-
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
---------
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
-
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
--
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
-----------------
K
I
T
M
K
D
L
E
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
69.13
70%
-90
- C1 -
1IY0
1
FTSH_THET8
A:
[11-252]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
P
K
V
T
F
K
D
V
A
G
A
E
E
A
K
E
E
L
K
E
I
V
E
F
-
L
K
N
P
S
R
F
H
E
M
G
A
R
I
P
K
G
V
L
L
V
G
P
P
G
V
G
K
T
H
L
A
R
A
V
A
G
E
A
-
R
V
P
F
I
T
A
S
G
S
D
F
V
E
M
F
V
G
V
G
A
A
R
V
R
D
L
F
E
T
A
K
R
H
A
P
C
I
V
F
I
D
E
I
D
A
V
G
R
K
R
-------
N
D
E
R
E
Q
T
L
N
Q
L
L
V
E
M
D
G
F
E
-
K
-
D
T
A
I
V
V
M
A
A
T
N
R
P
D
I
L
D
P
A
L
L
R
P
G
R
F
D
R
Q
I
A
I
D
A
P
D
V
K
G
R
E
Q
I
L
R
I
H
A
R
G
K
P
L
A
--
E
D
V
D
L
--
A
L
L
A
K
R
T
P
G
F
V
G
A
D
L
E
N
L
L
N
E
A
A
L
L
A
A
R
E
G
R
R
-----------------
K
I
T
M
K
D
L
E
E
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
PsiBlast_CBE
67.56
62%
-100
- C1 -
2R65
1
FTSH_HELPY
D:
[1-259]
--------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
A
E
-
K
P
N
V
R
F
K
D
M
A
G
N
E
E
A
K
E
E
V
V
E
I
V
D
F
-
L
K
Y
P
E
R
Y
A
N
L
G
A
K
I
P
K
G
V
L
L
V
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
G
E
A
-
H
V
P
F
F
S
M
G
G
S
S
F
I
E
M
F
V
G
L
G
A
S
R
V
R
D
L
F
E
T
A
K
K
Q
A
P
S
I
I
F
I
D
E
I
D
A
I
G
K
---------
N
D
E
R
E
Q
T
L
N
Q
L
L
A
E
M
D
G
F
G
S
E
-
N
A
P
V
I
V
L
A
A
T
N
R
P
E
I
L
D
P
A
L
M
R
P
G
R
F
D
R
Q
V
L
V
D
K
P
D
F
N
G
R
V
E
I
L
K
V
H
I
K
G
V
K
L
A
--
N
D
V
N
L
--
Q
E
V
A
K
L
T
A
G
L
A
G
A
D
L
A
N
I
I
N
E
A
A
L
L
A
G
R
N
N
Q
K
-----------------
E
V
R
Q
Q
H
L
K
E
A
V
E
R
G
I
A
G
L
E
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
67.46
62%
-94
- C1 -
2R65
1
FTSH_HELPY
A:
[1-259]
--------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
A
E
-
K
P
N
V
R
F
K
D
M
A
G
N
E
E
A
K
E
E
V
V
E
I
V
D
F
-
L
K
Y
P
E
R
Y
A
N
L
G
A
K
I
P
K
G
V
L
L
V
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
G
E
A
-
H
V
P
F
F
S
M
G
G
S
S
F
I
E
M
F
V
G
L
G
A
S
R
V
R
D
L
F
E
T
A
K
K
Q
A
P
S
I
I
F
I
D
E
I
D
A
I
G
K
---------
N
D
E
R
E
Q
T
L
N
Q
L
L
A
E
M
D
G
F
G
S
E
-
N
A
P
V
I
V
L
A
A
T
N
R
P
E
I
L
D
P
A
L
M
R
P
G
R
F
D
R
Q
V
L
V
D
K
P
D
F
N
G
R
V
E
I
L
K
V
H
I
K
G
V
K
L
A
--
N
D
V
N
L
--
Q
E
V
A
K
L
T
A
G
L
A
G
A
D
L
A
N
I
I
N
E
A
A
L
L
A
G
R
N
N
Q
K
-----------------
E
V
R
Q
Q
H
L
K
E
A
V
E
R
G
I
A
G
L
E
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
123
HHSearch
66.52
41%
-84
- C1 -
4KO8
2
TERA_HUMAN
A:
[199-461]
--------------------------------------------------------------------------------------------------------------------------------------------------------------
N
E
V
G
Y
D
D
I
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
-
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
T
---
H
G
E
V
E
R
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
-
Q
-
R
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
N
M
K
L
A
--
D
D
V
D
L
--
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
K
M
D
LIDLEDETID
A
E
V
M
N
S
L
A
V
T
M
D
D
F
R
W
A
L
S
Q
S
N
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
44
PsiBlast_CBE
66.24
62%
-97
- C1 -
2R65
1
FTSH_HELPY
B:
[1-259]
--------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
A
E
-
K
P
N
V
R
F
K
D
M
A
G
N
E
E
A
K
E
E
V
V
E
I
V
D
F
-
L
K
Y
P
E
R
Y
A
N
L
G
A
K
I
P
K
G
V
L
L
V
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
G
E
A
-
H
V
P
F
F
S
M
G
G
S
S
F
I
E
M
F
V
G
L
G
A
S
R
V
R
D
L
F
E
T
A
K
K
Q
A
P
S
I
I
F
I
D
E
I
D
A
I
G
K
---------
N
D
E
R
E
Q
T
L
N
Q
L
L
A
E
M
D
G
F
G
S
E
-
N
A
P
V
I
V
L
A
A
T
N
R
P
E
I
L
D
P
A
L
M
R
P
G
R
F
D
R
Q
V
L
V
D
K
P
D
F
N
G
R
V
E
I
L
K
V
H
I
K
G
V
K
L
A
--
N
D
V
N
L
--
Q
E
V
A
K
L
T
A
G
L
A
G
A
D
L
A
N
I
I
N
E
A
A
L
L
A
G
R
N
N
Q
K
-----------------
E
V
R
Q
Q
H
L
K
E
A
V
E
R
G
I
A
G
L
E
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
PsiBlast_CBE
65.81
62%
-92
- C1 -
2R65
1
FTSH_HELPY
E:
[1-259]
--------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
A
E
-
K
P
N
V
R
F
K
D
M
A
G
N
E
E
A
K
E
E
V
V
E
I
V
D
F
-
L
K
Y
P
E
R
Y
A
N
L
G
A
K
I
P
K
G
V
L
L
V
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
G
E
A
-
H
V
P
F
F
S
M
G
G
S
S
F
I
E
M
F
V
G
L
G
A
S
R
V
R
D
L
F
E
T
A
K
K
Q
A
P
S
I
I
F
I
D
E
I
D
A
I
G
K
---------
N
D
E
R
E
Q
T
L
N
Q
L
L
A
E
M
D
G
F
G
S
E
-
N
A
P
V
I
V
L
A
A
T
N
R
P
E
I
L
D
P
A
L
M
R
P
G
R
F
D
R
Q
V
L
V
D
K
P
D
F
N
G
R
V
E
I
L
K
V
H
I
K
G
V
K
L
A
--
N
D
V
N
L
--
Q
E
V
A
K
L
T
A
G
L
A
G
A
D
L
A
N
I
I
N
E
A
A
L
L
A
G
R
N
N
Q
K
-----------------
E
V
R
Q
Q
H
L
K
E
A
V
E
R
G
I
A
G
L
E
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
43
PsiBlast_CBE
64.72
62%
-87
- C1 -
2R65
1
FTSH_HELPY
C:
[1-259]
--------------------------------------------------------------------------------------------------------------------------------------------------------
I
N
A
E
-
K
P
N
V
R
F
K
D
M
A
G
N
E
E
A
K
E
E
V
V
E
I
V
D
F
-
L
K
Y
P
E
R
Y
A
N
L
G
A
K
I
P
K
G
V
L
L
V
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
G
E
A
-
H
V
P
F
F
S
M
G
G
S
S
F
I
E
M
F
V
G
L
G
A
S
R
V
R
D
L
F
E
T
A
K
K
Q
A
P
S
I
I
F
I
D
E
I
D
A
I
G
K
---------
N
D
E
R
E
Q
T
L
N
Q
L
L
A
E
M
D
G
F
G
S
E
-
N
A
P
V
I
V
L
A
A
T
N
R
P
E
I
L
D
P
A
L
M
R
P
G
R
F
D
R
Q
V
L
V
D
K
P
D
F
N
G
R
V
E
I
L
K
V
H
I
K
G
V
K
L
A
--
N
D
V
N
L
--
Q
E
V
A
K
L
T
A
G
L
A
G
A
D
L
A
N
I
I
N
E
A
A
L
L
A
G
R
N
N
Q
K
-----------------
E
V
R
Q
Q
H
L
K
E
A
V
E
R
G
I
A
G
L
E
K
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
64.63
45%
-87
- C1 -
3H4M
1
PAN_METJA
A:
[5-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
E
V
D
E
R
P
N
V
R
Y
E
D
I
G
G
L
E
K
Q
M
Q
E
I
R
E
V
V
E
L
P
L
K
H
P
E
L
F
E
K
V
G
I
E
P
P
K
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
T
E
T
-
N
A
T
F
I
R
V
V
G
S
E
L
V
K
K
F
I
G
E
G
A
S
L
V
K
D
I
F
K
L
A
K
E
K
A
P
S
I
I
F
I
D
E
I
D
A
I
A
A
K
R
T
D
A
L
T
G
G
D
R
E
V
Q
R
T
L
M
Q
L
L
A
E
M
D
G
F
D
-
A
-
R
G
D
V
K
I
I
G
A
T
N
R
P
D
I
L
D
P
A
I
L
R
P
G
R
F
D
R
I
I
E
V
P
A
P
D
E
K
G
R
L
E
I
L
K
I
H
T
R
K
M
N
L
A
--
E
D
V
N
L
--
E
E
I
A
K
M
T
E
G
C
V
G
A
E
L
K
A
I
C
T
E
A
G
M
N
A
I
R
E
L
R
D
-----------------
Y
V
T
M
D
D
F
R
K
A
V
E
K
I
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
PsiBlast_CBE
64.43
45%
-83
- C1 -
3H4M
1
PAN_METJA
B:
[5-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
E
V
D
E
R
P
N
V
R
Y
E
D
I
G
G
L
E
K
Q
M
Q
E
I
R
E
V
V
E
L
P
L
K
H
P
E
L
F
E
K
V
G
I
E
P
P
K
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
T
E
T
-
N
A
T
F
I
R
V
V
G
S
E
L
V
K
K
F
I
G
E
G
A
S
L
V
K
D
I
F
K
L
A
K
E
K
A
P
S
I
I
F
I
D
E
I
D
A
I
A
A
K
R
T
D
A
L
T
G
G
D
R
E
V
Q
R
T
L
M
Q
L
L
A
E
M
D
G
F
D
-
A
-
R
G
D
V
K
I
I
G
A
T
N
R
P
D
I
L
D
P
A
I
L
R
P
G
R
F
D
R
I
I
E
V
P
A
P
D
E
K
G
R
L
E
I
L
K
I
H
T
R
K
M
N
L
A
--
E
D
V
N
L
--
E
E
I
A
K
M
T
E
G
C
V
G
A
E
L
K
A
I
C
T
E
A
G
M
N
A
I
R
E
L
R
D
-----------------
Y
V
T
M
D
D
F
R
K
A
V
E
K
I
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
PsiBlast_CBE
64.07
45%
-87
- C1 -
3H4M
1
PAN_METJA
C:
[5-259]
-------------------------------------------------------------------------------------------------------------------------------------------------------
A
M
E
V
D
E
R
P
N
V
R
Y
E
D
I
G
G
L
E
K
Q
M
Q
E
I
R
E
V
V
E
L
P
L
K
H
P
E
L
F
E
K
V
G
I
E
P
P
K
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
L
A
K
A
V
A
T
E
T
-
N
A
T
F
I
R
V
V
G
S
E
L
V
K
K
F
I
G
E
G
A
S
L
V
K
D
I
F
K
L
A
K
E
K
A
P
S
I
I
F
I
D
E
I
D
A
I
A
A
K
R
T
D
A
L
T
G
G
D
R
E
V
Q
R
T
L
M
Q
L
L
A
E
M
D
G
F
D
-
A
-
R
G
D
V
K
I
I
G
A
T
N
R
P
D
I
L
D
P
A
I
L
R
P
G
R
F
D
R
I
I
E
V
P
A
P
D
E
K
G
R
L
E
I
L
K
I
H
T
R
K
M
N
L
A
--
E
D
V
N
L
--
E
E
I
A
K
M
T
E
G
C
V
G
A
E
L
K
A
I
C
T
E
A
G
M
N
A
I
R
E
L
R
D
-----------------
Y
V
T
M
D
D
F
R
K
A
V
E
K
I
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
85
PsiBlast_CBE
62.67
44%
-88
- C1 -
3HU3
2
TERA_HUMAN
A:
[203-430]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
D
I
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
-
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
--
T
H
G
E
V
E
R
-
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
-
Q
-
R
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
N
M
K
L
A
--
D
D
V
D
L
--
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
K
M
D
-----------------
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
84
PsiBlast_CBE
62.10
44%
-86
- C1 -
3HU3
3
TERA_HUMAN
B:
[203-430]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
D
I
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
-
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
--
T
H
G
E
V
E
R
-
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
-
Q
-
R
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
N
M
K
L
A
--
D
D
V
D
L
--
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
K
M
D
-----------------
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
127
HHSearch
61.97
51%
-97
- C1 -
2QZ4
1
A:
[2-254]
---------------------------------------------------------------------------------------------------------------------------------------------------------------
G
V
S
F
K
D
V
A
G
M
H
E
A
K
L
E
V
R
E
F
V
D
Y
-
L
K
S
P
E
------
A
K
V
P
K
G
A
L
L
L
G
P
P
G
C
G
K
T
L
L
A
K
A
V
A
T
E
A
-
Q
V
P
F
L
A
M
A
G
A
E
F
V
E
V
I
G
G
L
G
A
A
R
V
R
S
L
F
K
E
A
R
A
R
A
P
C
I
V
Y
I
D
E
I
------------------
E
Q
T
L
N
Q
L
L
V
E
M
D
G
M
G
-
T
-
T
D
H
V
I
V
L
A
S
T
N
R
A
D
I
L
D
G
A
L
M
R
P
G
R
L
D
R
H
V
F
I
D
L
P
T
L
Q
E
R
R
E
I
F
E
Q
H
L
K
S
L
K
L
T
QS
S
T
F
Y
S
--
Q
R
L
A
E
L
T
P
G
F
S
G
A
D
I
A
N
I
C
N
E
A
A
L
H
-------------------------
V
H
T
L
N
F
E
Y
A
V
E
R
V
L
A
G
T
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
83
PsiBlast_CBE
61.80
44%
-85
- C1 -
4KO8
2
TERA_HUMAN
A:
[203-430]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
D
I
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
-
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
--
T
H
G
E
V
E
R
-
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
-
Q
-
R
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
N
M
K
L
A
--
D
D
V
D
L
--
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
K
M
D
-----------------
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
60.71
50%
-97
- C1 -
2QZ4
1
A:
[3-256]
----------------------------------------------------------------------------------------------------------------------------------------------------------------
V
S
F
K
D
V
A
G
M
H
E
A
K
L
E
V
R
E
F
V
D
Y
-
L
K
S
P
E
------
A
K
V
P
K
G
A
L
L
L
G
P
P
G
C
G
K
T
L
L
A
K
A
V
A
T
E
A
-
Q
V
P
F
L
A
M
A
G
A
E
F
V
E
V
I
G
G
L
G
A
A
R
V
R
S
L
F
K
E
A
R
A
R
A
P
C
I
V
Y
I
D
E
I
------------------
E
Q
T
L
N
Q
L
L
V
E
M
D
G
M
G
-
T
-
T
D
H
V
I
V
L
A
S
T
N
R
A
D
I
L
D
G
A
L
M
R
P
G
R
L
D
R
H
V
F
I
D
L
P
T
L
Q
E
R
R
E
I
F
E
Q
H
L
K
S
L
K
L
T
--
Q
S
S
T
F
Y
S
Q
R
L
A
E
L
T
P
G
F
S
G
A
D
I
A
N
I
C
N
E
A
A
L
H
-------------------------
V
H
T
L
N
F
E
Y
A
V
E
R
V
L
A
G
T
A
K
K
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
92
PsiBlast_CBE
60.27
45%
-89
- C1 -
1E32
1
TERA_MOUSE
A:
[203-430]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
D
V
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
-
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
--
T
H
G
E
V
E
R
-
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
-
Q
-
R
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
N
M
K
L
A
--
D
D
V
D
L
--
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
K
M
D
-----------------
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
82
PsiBlast_CBE
60.25
44%
-83
- C1 -
4KO8
3
TERA_HUMAN
B:
[203-430]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
D
I
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
-
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
--
T
H
G
E
V
E
R
-
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
-
Q
-
R
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
N
M
K
L
A
--
D
D
V
D
L
--
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
K
M
D
-----------------
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
69
PsiBlast_CBE
60.24
45%
-91
- C1 -
1R7R
1
TERA_MOUSE
A:
[203-464]
------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
D
V
G
G
C
R
K
Q
L
A
Q
I
K
E
M
V
E
L
P
L
R
H
P
A
L
F
K
A
I
G
V
K
P
P
R
G
I
L
L
Y
G
P
P
G
T
G
K
T
L
I
A
R
A
V
A
N
E
T
-
G
A
F
F
F
L
I
N
G
P
E
I
M
S
K
L
A
G
E
S
E
S
N
L
R
K
A
F
E
E
A
E
K
N
A
P
A
I
I
F
I
D
E
L
D
A
I
A
P
K
R
E
K
--
T
H
G
E
V
E
R
-
R
I
V
S
Q
L
L
T
L
M
D
G
L
K
----
A
H
V
I
V
M
A
A
T
N
R
P
N
S
I
D
P
A
L
R
R
F
G
R
F
D
R
E
V
D
I
G
I
P
D
A
T
G
R
L
E
I
L
Q
I
H
T
K
N
M
K
L
A
--
D
D
V
D
L
--
E
Q
V
A
N
E
T
H
G
H
V
G
A
D
L
A
A
L
C
S
E
A
A
L
Q
A
I
R
K
K
M
D
-----------------
L
I
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
129
HHSearch
56.21
36%
-91
- C1 -
2ZAN
2
VPS4B_MOUSE
A:
[126-356]
----------------------------------------------------------------------------------------------------------------------------------------------------------
I
E
-
R
P
N
V
K
W
S
D
V
A
G
L
E
G
A
K
E
A
L
K
E
A
V
I
L
P
I
K
F
P
H
L
F
T
G
-
K
R
T
P
W
R
G
I
L
L
F
G
P
P
G
T
G
K
S
Y
L
A
K
A
V
A
T
E
A
N
N
S
T
F
F
S
I
S
S
S
---------
S
E
K
L
V
K
N
L
F
Q
L
A
R
E
N
K
P
S
I
I
F
I
D
E
I
D
S
L
C
G
S
R
S
E
N
---
E
S
E
A
A
R
R
I
K
T
E
F
L
V
Q
M
Q
G
V
G
-
V
D
N
D
G
I
L
V
L
G
A
T
N
I
P
W
V
L
D
S
A
I
R
R
--
R
F
E
K
R
I
Y
I
P
L
P
E
A
H
A
R
A
A
M
F
R
L
H
L
G
S
T
Q
N
S
L-
T
E
A
D
F
--
Q
E
L
G
R
K
T
D
G
Y
S
G
A
D
I
S
I
I
V
R
D
A
L
M
Q
P
V
R
K
V
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------