@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3663c: (2016-05-22 )
MSVPAAPLLSVEGLEVTFGTDAPAVCGVDLAVRSGQTVAVVGESGSGKSTTAAAILGLLPAGGRITAGRVVFDGRDITGADAKRLRSIRGREIGYVPQDPMTNLNPVWKVGFQVTEALRANTDGRAARRRAVELLAEAGLPDPAKQAGRYPHQLSGGMCQRALIAIGLAGRPRLLIADEPTSALDVTVQRQVLDHLQGLTDELGTALLLITHDLALAAQRAEAVVVVRRGVVVESGAAQSILQSPQHEYTRRLVAAAPSLTARSRRPPESRSRATTQAGDILVVSELTKIYRESRGAPWRRVESRAVDGVSFRLPRASTLAIVGESGSGKSTLARMVLGLLQPTSGTVVFDGTYDVGALARDQVLAFRRRVQPVFQNPYSSLDPMYSVFRAIEEPLRVHHVGDRRQRQRAVRELVDQVALPSSILGRRPRELSGGQRQRVAIARALALRPEVLVCDEAVSALDVLVQAQILDLLADLQADLGLTYLFISHDLAVIRQIADDVLVMRAGRVVEHASTEEVFSRPRHEYTRQLLQAIPGAPSAPRKVGNL
Atome Classification :
(30 SA)
.........10........20-.........30........40........50........60........70........80........90........100.......110.......120-------------..----..--------------.--...130......--.140.......150.......160.......170.......180.......190.......200.......210.......220.......230.-......240.....-------------------------.--------.250------------------------.-----------------------...-.--.-----------------------------------------------------------.--.260...------------.-.-------------------------..----------------------270-------------------------------------------.-------------------------------------------.------------------------------------------------.----------.....280.......290.......300.......310.......320.......330.......340.......350.--..------------....360......-.370......-.380.......390.......400.--........410.......420------.----------.......430.......440.......450.......460.----......470........480.......490.......500.......510.......520.......530.......540......-----------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSVPAA
P
L
L
S
V
E
G
L
E
V
T
FGT--DAPAV
C
G
V
D
L
A
VRSG
Q
T
V
A
V
V
GESGSGK
S
T
T
A
A
A
I
L
G
LLPAG
G
R
I
T
A
G
R
V
V
FDGRDIT
G
A
D
A
K
R
L
R
S
I
RGREIGYVPQDPMTNLN
P
V
W
K
V
G
F
Q
V
T
E
A
L
RAN--------------TD----
G
R
--------------
A
--
A
R
R
R
A
V
E
L
L
A
EA--GLPD
P
A
K
Q
AGRYPHQLS
G
G
M
C
Q
R
A
L
I
AIGLAGR
P
R
L
L
I
ADEPTS
A
L
D
V
T
V
Q
R
Q
V
L
D
H
L
Q
G
L
T
D
E
LG
T
A
L
L
L
I
T
H
D
L
A
L
A
A
QRA
E
A
V
V
V
V
RR
G
V
V
V-ES
G
A
A
Q
S
I
L
QS
P
Q
H
-------------------------
E
--------
Y
T
R
-------------------------
R
-----------------------
L
V
A-A--A-----------------------------------------------------------P--SLTARSR------------R-P-------------------------PE----------------------SR--------------------------------------------S-------------------------------------------R------------------------------------------------A----------TTQAG
D
I
L
V
V
S
E
L
T
K
I
Y
R
E
SRGAP
W
R
R
V
E
SRAVDG
V
S
F
RLPR
A
S
T
L
A
I
V
GESGS
G
K
S
T
L
A
R
M
V
L
G
L
LQPTS
G
T
V
V
F
DGT--Y
D
------------
V
G
A
L
A
R
D
Q
V
L
A
F
R
-
R
RV
Q
P
V
F
QNP-YSSL
D
P
M
Y
S
V
F
R
A
I
E
E
P
L
R
VHH--V--G
D
R
R
Q
R
Q
R
A
V
R
E
L
V
D
Q
VAL
P
-------
S
----------
S
I
LGRR
P
R
ELSGG
Q
R
Q
R
V
A
I
A
R
A
LALRP
E
V
L
V
C
D
E
A
V
S
A
L
D
----
V
L
V
Q
A
Q
I
-
L
D
L
L
A
D
L
Q
A
DL
G
L
T
Y
L
F
ISH
D
L
A
V
I
R
Q
I
A
D
D
V
L
V
M
RAGRVVEHA
S
T
E
E
V
F
SR
P
R
H
E
Y
T
R
Q
L
L
Q
AIPGAPSAPRKVGNL-----------------------------------------------------------------------------------------------
110
HHSearch
85.70
28%
-112
- C2 -
4F4C
2
PGP1_CAEEL
A:
[414-1306]
------
G
D
I
T
V
E
N
V
H
F
T
Y
P
S
RP
D
V
P
I
L
R
G
M
N
L
R
V
N
A
G
Q
T
V
A
L
V
G
S
S
G
C
G
K
S
T
I
I
S
L
L
L
R
Y
Y
D
V
----
L
K
G
K
I
T
I
D
G
V
D
V
R
D
I
N
L
E
F
---
L
-
R
K
N
V
A
V
V
S
Q
E
P
A
L
--
F
-
N
C
T
I
E
E
N
I
S
L
G
K
E
G
I
--------------
T
R
----
E
E
M
V
------------
A
A
C
K
M
A
N
A
E
K
F
I
K
T
L
PN
G
Y
---
N
T
L
V
G
D
R
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
S
E
G
I
V
Q
Q
A
L
D
K
A
A
--
K
G
R
T
T
I
I
I
A
H
R
L
S
T
I
R
-
N
A
D
L
I
I
S
C
K
N
G
Q
V
V
-
E
V
G
D
H
R
A
L
M
A
Q
Q
G
L
Y
Y
D
L
V
T
A
Q
T
F
T
D
A
V
D
S
A
A
E
GER
I
G
K
D
A
L
S
R
L
K
Q
E
L
E
E
NNAQKTN
L
F
E
I
L
Y
H
A
RPH
A
L
S
L
F
I
G
M
S
T
A
T
I
G
G
F
I
Y
P
T
Y
S
V
F
F
T
S
F
M
N
V
F
A
G
-
N
--
P
ADFL
S
Q
G
H
F
W
A
L
M
F
L
V
L
A
A
A
Q
G
I
C
S
F
L
M
T
F
F
M
G
I
A
S
E
S
L
T
R
D
L
R
N
K
L
F
R
N
V
L
S
QHIGFF
D
SP
Q
N
A
S
G
K
I
S
T
R
L
A
T
D
V
P
N
L
R
T
A
I
D
F
R
F
S
T
V
I
T
T
L
V
S
M
V
A
G
I
G
L
A
F
F
Y
G
W
Q
M
A
L
L
I
I
A
I
L
P
I
V
A
F
G
Q
Y
L
R
G
RR
F
T
GKNVKSA
S
E
F
A
D
S
G
K
I
A
I
E
A
I
E
N
V
R
T
V
Q
A
L
AR
E
D
T
F
Y
E
N
F
C
E
K
L
D
I
P
H
K
E
A
I
K
E
A
F
I
Q
G
L
S
Y
G
C
A
S
S
V
L
Y
L
L
N
T
C
A
Y
R
M
G
L
A
L
I
I
TDP
P
TMQ
P
M
R
V
L
R
V
M
Y
A
I
T
I
S
T
S
TLGFAT
S
Y
F
P
E
Y
A
K
A
T
F
A
G
G
I
I
F
G
M
L
R
KI
S
KIDSLSLAGE
K
K
K
L
Y
G
K
V
I
F
K
N
V
R
F
A
Y
P
E
R
P
--
E
I
-----
E
I
L
K
G
L
S
F
S
V
E
P
G
Q
T
L
A
L
V
G
P
S
G
C
G
K
S
T
V
V
A
L
L
E
R
F
Y
D
T
L
G
G
E
I
F
I
D
G
S
---
E
------------
I
K
T
L
N
---
P
E
H
T
R
-
S
Q
I
A
I
V
S
Q
E
P
-
T
--
L
F
-
D
C
S
I
A
E
N
I
I
Y
G
L
D
P
S
S
--
V
-------
T
M
A
Q
V
E
E
A
A
R
L
A
N
I
H
-------
N
F
I
A
E
LPEGFE
T
R
V
G
D
R
G
T
Q
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
V
R
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
----
T
E
S
E
K
V
V
-
Q
E
A
L
D
R
A
R
--
E
G
R
T
C
I
V
I
A
H
R
L
N
T
V
M
N
-
A
D
C
I
A
V
V
S
N
G
T
I
I
E
K
G
T
H
T
Q
L
M
S
E
K
------------------------------------------------------------------------------------------------------------------------
109
HHSearch
80.83
26%
-108
- C2 -
4FIN
13
ETTA_ECOLI
A:
[1-520]
---
M
A
Q
F
V
Y
T
M
H
R
V
G
K
V
V
P
P
--
K
R
H
I
L
K
N
I
S
L
S
F
F
P
G
A
K
I
G
V
L
G
L
N
G
A
G
K
S
T
L
L
R
I
M
A
G
I
D
K
D
----
I
E
G
E
A
R
P
Q
P
---------------
D
I
K
I
G
Y
L
P
Q
E
P
Q
--
L
N
P
E
H
T
V
R
E
S
I
E
E
A
V
S
E
V
V
N
A
L
K
R
L
D
E
V
Y
A
L
Y
A
D
PDAD
F
D
K
L
A
A
E
Q
G
R
L
E
E
I
IQ---
L
N
V
Q
L
E
R
A
A
D
A
L
--
R
L
P
----
D
W
D
A
K
I
A
N
L
S
G
G
E
R
R
R
V
A
L
C
R
L
L
L
E
K
P
D
M
L
L
L
D
E
P
T
N
H
L
D
A
E
S
V
A
W
L
E
R
F
L
H
D
F
----
E
G
T
V
V
A
I
T
H
D
R
Y
F
L
D
N
V
A
G
W
I
L
E
L
D
R
G
E
G
I
P
W
E
G
N
Y
S
S
W
L
E
Q
K
D
Q
-------------------------
R
--------
L
A
Q
-------------------------
E
A
S
Q
E
A
A
R
R
K
S
I
E
K
E
L
E
-------
W
V
R
Q
G
TK---------------------------------------------------------------
K
G
K
A
R
L
A
------------
R
-
F
-------------------------
E
E
----------------------
L
N
S
T
E
Y
Q
K
R
-------------------------------------
N
E
TNE
L
F
I
P
-----------------------------------
P
------------------------------------------------
G
----------
P
R
L
G
D
K
V
L
E
V
S
N
L
R
K
S
Y
G
D
-----
R
-----
L
L
I
D
D
L
S
F
S
I
P
K
G
A
I
V
G
I
I
G
P
N
G
A
G
K
S
T
L
F
R
M
I
S
G
Q
E
Q
P
D
S
G
T
I
T
L
G
E
T
---
V
---------------------------
K
L
A
S
V
D
Q
F
R
-
D
-
S
M
D
N
S
K
T
V
W
E
E
V
S
G
G
L
D
I
M
K
--
I
--
G
N
---
T
E
M
P
S
R
A
Y
V
G
R
F
N
F
K
-------
G
----------
V
D
Q
G
K
R
V
G
E
L
S
G
G
E
R
G
R
L
H
L
A
K
L
L
Q
V
G
G
N
M
L
L
L
D
E
P
T
N
D
L
D
----
I
E
T
L
R
A
L
-
E
N
A
L
L
E
F
----
P
G
C
A
M
V
I
S
H
D
R
W
F
L
D
R
I
A
T
H
I
L
D
Y
Q
D
E
G
K
V
------------------------------------------------------------------------------------------------------------------------------------
134
Fugue
78.14
35%
-122
- C2 -
3TUZ
3
METN_ECOLI
H:
[23-362]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
------
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
---
Q
E
------------
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
H
F
---
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
N
--
T
---
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
-------
D
----------
K
-
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
----
P
A
T
T
R
S
I
-
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
T
L
H
L
D
I
P
E
D
Y
Q
E
R
L
QAEPFTDCVPMLRLEFTGQSVDAPLLSETARRFNVNNNIISAQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEV-------------
3
PsiBlast_PDB
72.08
36%
-125
- C2 -
3TUZ
1
METN_ECOLI
C:
[24-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
----
R
T
I
Q
--
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
---
E
------------
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
---
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
N
--
T
--
P
-
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
-------
D
----------
K
-
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
----
P
A
T
T
R
S
I
-
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
-------------------------------------------------------------------------------------------------------------
130
HHSearch
72.01
36%
-121
- C2 -
1Z47
1
?
A:
[12-246]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
M
T
I
E
F
V
G
V
E
K
I
Y
P
G
G
----
A
-----
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
T
K
G
D
V
W
I
G
G
K
---
R
------------
V
T
D
L
-----
P
P
Q
K
-
R
N
V
G
L
V
F
Q
N
Y
-
A
--
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
L
R
E
K
R
--
V
--
P
-
K
D
E
M
D
A
R
V
R
E
L
L
R
F
M
R
L
E
------------------
S
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
----
T
Q
I
R
R
E
L
-
R
T
F
V
R
Q
V
H
D
E
M
G
V
T
S
V
F
V
T
H
D
Q
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
P
E
E
V
Y
E
K
P
G
T
L
F
V
A
S
F
I
---------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
69.74
36%
-123
- C2 -
3TUI
1
METN_ECOLI
C:
[24-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
----
R
T
I
Q
--
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
---
E
------------
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
---
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
N
--
T
--
P
-
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
-------
D
----------
K
-
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
----
P
A
T
T
R
S
I
-
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
-------------------------------------------------------------------------------------------------------------
129
HHSearch
68.58
33%
-130
- C2 -
4TQU
-
?
S:
[3-237]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
V
S
I
Q
N
V
V
K
R
Y
D
K
-----
T
-----
T
V
V
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
I
S
G
G
T
I
R
I
D
G
R
---
V
------------
I
N
D
L
A
-----
P
K
D
-
R
D
V
A
M
V
F
Q
N
Y
-
A
--
L
Y
P
H
L
N
V
R
D
N
I
S
F
G
L
R
L
K
R
--
T
--
K
K
-
S
V
I
D
A
A
V
K
T
A
A
D
I
L
G
L
Q
------------------
P
L
L
E
R
K
P
S
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
----
A
K
L
R
T
Q
M
-
R
A
E
I
K
R
L
H
Q
R
L
G
T
T
V
I
Y
V
T
H
D
Q
V
E
A
M
T
L
A
D
R
I
V
V
M
R
D
G
L
I
E
Q
I
G
K
P
M
D
L
F
L
H
P
A
N
T
F
V
A
S
F
I
G
S
-------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
68.16
36%
-117
- C2 -
3TUZ
1
METN_ECOLI
G:
[24-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
----
R
T
I
Q
--
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
---
E
------------
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
---
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
N
--
T
--
P
-
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
-------
D
----------
K
-
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
----
P
A
T
T
R
S
I
-
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
-------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
67.56
36%
-125
- C2 -
3TUZ
1
METN_ECOLI
H:
[24-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
----
R
T
I
Q
--
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
---
E
------------
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
---
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
N
--
T
--
P
-
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
-------
D
----------
K
-
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
----
P
A
T
T
R
S
I
-
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
-------------------------------------------------------------------------------------------------------------
24
PsiBlast_CBE
67.47
36%
-123
- C2 -
3TUI
1
METN_ECOLI
H:
[24-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
----
R
T
I
Q
--
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
---
E
------------
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
---
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
N
--
T
--
P
-
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
-------
D
----------
K
-
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
----
P
A
T
T
R
S
I
-
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
-------------------------------------------------------------------------------------------------------------
141
Fugue
67.27
29%
-108
- C2 -
1OXS
23
?
C:
[1-352]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
V
R
I
I
V
K
N
V
S
K
V
F
K
K
G
K
V
V
A
L
D
-----
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
---
R
L
------------
V
A
S
N
G
K
L
I
V
P
P
E
D
-
R
K
I
G
M
V
F
Q
T
---
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
L
T
N
M
K
--
M
---
S
K
E
E
I
R
K
R
V
E
E
V
A
K
I
L
D
I
--------
H
----------
H
V
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
----
A
R
M
R
D
S
A
-
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
V
S
I
Q
V
A
S
L
I
G
E
I
N
E
L
E
G
K
V
T
N
E
G
V
V
IGSLRFPVSVSSDRAIIGIRPEDVKLSKDVIKDDSWILVGKGKVKVIGYQGGLFRITITPLDSEEEIFTYSDHPIHSGEEVLVYVRKDKIKVFEK
26
PsiBlast_CBE
66.93
36%
-118
- C2 -
3TUI
1
METN_ECOLI
D:
[24-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
----
R
T
I
Q
--
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
---
E
------------
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
---
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
N
--
T
--
P
-
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
-------
D
----------
K
-
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
----
P
A
T
T
R
S
I
-
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
-------------------------------------------------------------------------------------------------------------
25
PsiBlast_CBE
66.93
36%
-118
- C2 -
3TUI
1
METN_ECOLI
G:
[24-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
----
R
T
I
Q
--
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
---
E
------------
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
---
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
N
--
T
--
P
-
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
-------
D
----------
K
-
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
----
P
A
T
T
R
S
I
-
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
-------------------------------------------------------------------------------------------------------------
27
PsiBlast_CBE
66.54
35%
-115
- C2 -
2IT1
1
?
B:
[18-238]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
K
---
D
------------
V
T
E
L
P
P
K
D
------
R
N
V
G
L
V
F
Q
N
---
W
A
L
Y
P
H
M
T
V
Y
K
N
I
A
F
P
L
E
L
R
K
-----
A
P
R
E
E
I
D
K
K
V
R
E
V
A
K
M
L
H
I
--------
D
----------
K
L
L
N
R
Y
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
----
A
L
L
R
L
E
V
-
R
A
E
L
K
R
L
Q
K
E
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
Y
K
P
K
Y
K
F
V
G
G
F
L
G
N
P
P
-----------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
65.78
35%
-115
- C2 -
2IT1
-
?
A:
[18-238]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
T
S
G
K
I
Y
F
D
E
K
---
D
------------
V
T
E
L
P
P
K
D
------
R
N
V
G
L
V
F
Q
N
---
W
A
L
Y
P
H
M
T
V
Y
K
N
I
A
F
P
L
E
L
R
K
-----
A
P
R
E
E
I
D
K
K
V
R
E
V
A
K
M
L
H
I
--------
D
----------
K
L
L
N
R
Y
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
----
A
L
L
R
L
E
V
-
R
A
E
L
K
R
L
Q
K
E
L
G
I
T
T
V
Y
V
T
H
D
Q
A
E
A
L
A
M
A
D
R
I
A
V
I
R
E
G
E
I
L
Q
V
G
T
P
D
E
V
Y
Y
K
P
K
Y
K
F
V
G
G
F
L
G
N
P
P
-----------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
65.40
36%
-120
- C2 -
3TUZ
1
METN_ECOLI
D:
[24-266]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
----
R
T
I
Q
--
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
---
E
------------
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
---
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
N
--
T
--
P
-
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
-------
D
----------
K
-
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
----
P
A
T
T
R
S
I
-
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
-------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
64.40
36%
-118
- C2 -
3DHW
-
METN_ECOLI
C:
[1-243]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
----
R
T
I
Q
--
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
T
E
G
S
V
L
V
D
G
Q
---
E
------------
L
T
T
L
S
E
S
E
L
T
K
A
R
-
R
Q
I
G
M
I
F
Q
---
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
N
--
T
---
P
K
D
E
V
K
R
R
V
T
E
L
L
S
L
V
G
L
G
-------
D
----------
K
-
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
E
A
T
S
A
L
D
----
P
A
T
T
R
S
I
-
L
E
L
L
K
D
I
N
R
R
L
G
L
T
I
L
L
I
T
H
E
M
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
V
S
E
V
F
S
H
P
K
T
P
L
A
Q
K
F
I
Q
S
-------------------------------------------------------------------------------------------------------------
50
PsiBlast_CBE
63.90
32%
-110
- C2 -
1OXU
7
?
A:
[4-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
V
K
N
V
S
K
V
F
K
K
G
K
V
V
--------
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
--
L
-------------
V
A
S
N
G
K
L
I
V
P
P
E
D
-
R
K
I
G
M
V
F
Q
T
---
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
L
T
N
M
K
--
M
--
S
K
E
E
I
R
K
R
V
--
E
E
V
A
K
I
L
D
I
-------
H
----------
H
V
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
----
A
R
M
R
D
S
A
-
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
------------------------------------------------------------------------------------------------------------------------
47
PsiBlast_CBE
63.70
32%
-110
- C2 -
1OXV
7
?
A:
[4-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
V
K
N
V
S
K
V
F
K
K
G
K
V
V
--------
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
--
L
-------------
V
A
S
N
G
K
L
I
V
P
P
E
D
-
R
K
I
G
M
V
F
Q
T
---
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
L
T
N
M
K
--
M
--
S
K
E
E
I
R
K
R
V
--
E
E
V
A
K
I
L
D
I
-------
H
----------
H
V
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
----
A
R
M
R
D
S
A
-
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
------------------------------------------------------------------------------------------------------------------------
48
PsiBlast_CBE
63.27
32%
-107
- C2 -
1OXU
13
?
C:
[4-232]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
I
V
K
N
V
S
K
V
F
K
K
G
K
V
V
--------
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
S
T
G
E
L
Y
F
D
D
R
--
L
-------------
V
A
S
N
G
K
L
I
V
P
P
E
D
-
R
K
I
G
M
V
F
Q
T
---
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
L
T
N
M
K
--
M
--
S
K
E
E
I
R
K
R
V
--
E
E
V
A
K
I
L
D
I
-------
H
----------
H
V
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
----
A
R
M
R
D
S
A
-
R
A
L
V
K
E
V
Q
S
R
L
G
V
T
L
L
V
V
S
H
D
P
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
G
K
L
V
Q
V
G
K
P
E
D
L
Y
D
N
P
------------------------------------------------------------------------------------------------------------------------
54
PsiBlast_CBE
59.62
31%
-114
- C2 -
4MKI
4
ECFA2_CALS4
A:
[9-236]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
N
V
S
F
I
Y
N
E
--
G
T
P
Y
A
T
V
---
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
I
DI
T
D
------------
K
K
V
S
L
K
D
----
I
R
-
K
Q
V
G
L
V
F
Q
Y
P
-
E
Y
Q
L
F
E
-
E
T
V
F
K
D
I
A
F
G
P
S
N
L
G
--
L
--
S
E
E
E
V
K
E
R
-
V
Y
E
A
M
E
I
V
G
I
S
-------
K
----------
E
L
A
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
----
P
K
G
K
Q
E
I
-
L
N
K
I
K
E
I
H
D
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
R
E
V
F
---------------------------------------------------------------------------------------------------------------------------
57
PsiBlast_CBE
56.92
32%
-125
- C2 -
1VCI
1
?
A:
[27-253]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
N
K
L
N
L
T
I
K
D
G
E
F
L
V
L
L
G
P
S
G
C
G
K
T
T
T
L
R
M
I
A
G
L
E
E
P
T
E
G
R
I
Y
F
-
G
D
--
R
D
------------
V
T
Y
L
P
P
K
D
------
R
N
I
S
M
V
F
Q
---------
H
M
T
V
Y
E
N
I
A
F
P
L
--
K
K
--
F
P
K
D
E
I
D
K
R
V
R
W
A
A
E
L
L
-
Q
I
----------
E
----------
E
L
L
N
R
Y
P
A
Q
L
S
G
G
Q
R
Q
R
V
A
V
A
R
A
I
V
V
E
P
D
V
L
L
M
D
E
P
L
S
N
L
D
----
A
K
L
R
V
A
M
-
R
A
E
I
K
K
L
Q
Q
K
L
K
V
T
T
I
Y
V
T
H
D
Q
V
E
A
M
T
M
G
D
R
I
A
V
M
N
R
G
Q
L
L
Q
I
G
S
P
T
E
V
Y
L
R
P
N
S
V
F
V
A
T
F
I
----
G
A
P
E
-------------------------------------------------------------------------------------------------------
53
PsiBlast_CBE
56.62
31%
-111
- C2 -
4MKI
4
ECFA2_CALS4
B:
[9-236]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
E
N
V
S
F
I
Y
N
E
--
G
T
P
Y
A
T
V
---
A
L
K
D
I
N
F
S
I
D
D
E
E
F
V
G
I
I
G
H
T
G
S
G
K
S
T
L
I
Q
Q
L
N
G
L
L
K
P
S
K
G
K
I
Y
I
N
G
I
DI
T
D
------------
K
K
V
S
L
K
D
----
I
R
-
K
Q
V
G
L
V
F
Q
Y
P
-
E
Y
Q
L
F
E
-
E
T
V
F
K
D
I
A
F
G
P
S
N
L
G
--
L
--
S
E
E
E
V
K
E
R
-
V
Y
E
A
M
E
I
V
G
I
S
-------
K
----------
E
L
A
D
K
S
P
F
E
L
S
G
G
Q
K
R
R
V
A
I
A
G
I
L
A
M
R
P
K
I
L
I
L
D
E
P
T
A
G
L
D
----
P
K
G
K
Q
E
I
-
L
N
K
I
K
E
I
H
D
K
Y
K
M
I
T
I
L
V
S
H
N
M
E
D
I
A
R
I
A
D
K
I
I
V
M
N
R
G
K
I
E
L
I
G
T
P
R
E
V
F
---------------------------------------------------------------------------------------------------------------------------
106
PsiBlast_CBE
56.04
37%
-108
- C2 -
3FVQ
3
FBPC_NEIG1
B:
[20-230]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
--
T
---------------
I
F
S
K
N
T
N
L
P
V
R
E
R
R
L
G
Y
L
V
Q
E
---
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
L
G
N
G
K
GR
T
--
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
-----------
S
----------
E
L
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
----
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
-
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
------------------------------------------------------------------------------------------------------------------------
107
PsiBlast_CBE
54.92
37%
-107
- C2 -
3FVQ
3
FBPC_NEIG1
A:
[20-235]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
D
S
G
E
I
S
L
S
G
K
--
T
---------------
I
F
S
K
N
T
N
L
P
V
R
E
R
R
L
G
Y
L
V
Q
E
---
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
L
G
N
G
K
GR
T
--
A
Q
E
R
Q
R
I
E
A
M
L
E
L
T
G
I
-----------
S
----------
E
L
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
----
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
A
N
-
G
K
S
A
V
F
V
S
H
D
R
E
E
A
L
Q
Y
A
D
R
I
A
V
M
K
Q
G
R
I
L
Q
T
A
S
P
H
E
L
Y
R
Q
P
------------------------------------------------------------------------------------------------------------------------
61
PsiBlast_CBE
39.94
36%
-99
- C2 -
4AYX
2
ABCBA_HUMAN
A:
[363-574]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
---
H
D
------------
I
R
Q
L
---
N
P
V
W
L
R
-
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
A
D
D
P
S
S
V
----
T
--
A
E
E
I
Q
R
---
V
A
E
V
A
N
A
V
A
F
I
R
N
FPQGF
N
----------
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
-
E
A
-
L
D
R
L
M
D
-----
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
L
L
S
K
P
N
G
----------------------------------------------------------------------------------------------------------------------
60
PsiBlast_CBE
38.92
36%
-98
- C2 -
4AYW
1
ABCBA_HUMAN
A:
[394-598]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
---
H
D
------------
I
R
Q
L
---
N
P
V
W
L
R
-
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
A
D
D
P
S
S
V
----
T
--
A
E
E
I
Q
R
---
V
A
E
V
A
N
A
V
A
F
I
R
N
FPQGF
N
----------
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
----
L
D
A
E
N
E
Y
L
V
Q
-
E
A
-
L
D
R
L
M
D
-----
G
R
T
V
L
V
I
A
H
H
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
-----------------------------------------------------------------------------------------------------------------------------
68
PsiBlast_CBE
37.66
31%
-88
- C2 -
2PMK
1
A:
[21-235]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
---
H
D
LALAD
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
------
S
L
A
N
P
G
M
S
V
E
K
V
I
-------
Y
--
A
--
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
----------
N
----------
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
----
Y
E
S
E
H
V
I
-
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
-------------------------------------------------------------------------------------------------------------------
66
PsiBlast_CBE
37.65
31%
-86
- C2 -
2FF7
1
A:
[25-239]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
D
N
I
N
L
S
I
K
Q
G
E
V
I
G
I
V
G
R
S
G
S
G
K
S
T
L
T
K
L
I
Q
R
F
Y
I
P
E
N
G
Q
V
L
I
D
G
---
H
D
LALAD
P
N
W
L
R
R
Q
V
G
V
V
L
Q
D
N
V
L
L
N
R
-
S
I
I
D
N
I
------
S
L
A
N
P
G
M
S
V
E
K
V
I
-------
Y
--
A
--
A
K
L
A
G
A
H
D
F
I
S
E
L
R
E
G
Y
----------
N
----------
T
I
V
G
E
Q
G
A
G
L
S
G
G
Q
R
Q
R
I
A
I
A
R
A
L
V
N
N
P
K
I
L
I
F
D
E
A
T
S
A
L
D
----
Y
E
S
E
H
V
I
-
M
R
N
M
H
K
I
C
K
--
G
R
T
V
I
I
I
A
H
R
L
S
T
V
K
N
-
A
D
R
I
I
V
M
E
K
G
K
I
V
E
Q
G
K
H
K
E
L
L
S
E
P
E
S
L
Y
S
-------------------------------------------------------------------------------------------------------------------
62
PsiBlast_CBE
36.76
36%
-92
- C2 -
4AYT
2
ABCBA_HUMAN
A:
[363-567]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
S
L
S
I
P
S
G
S
V
T
A
L
V
G
P
S
G
S
G
K
S
T
V
L
S
L
L
L
R
L
Y
D
P
A
S
G
T
I
S
L
D
G
---
H
D
------------
I
R
Q
L
---
N
P
V
W
L
R
-
S
K
I
G
T
V
S
Q
E
P
I
L
F
S
C
S
I
A
E
N
I
A
Y
G
A
D
D
P
S
S
V
----
T
--
A
E
E
I
Q
R
---
V
A
E
V
A
N
A
V
A
F
I
R
N
FPQGF
N
----------
T
V
V
G
E
K
G
V
L
L
S
G
G
Q
K
Q
R
I
A
I
A
R
A
L
L
K
N
P
K
I
L
L
L
D
E
A
T
S
A
L
D
A
E
N
E
Y
L
V
Q
-
E
A
-
L
D
R
L
M
D
-----
G
R
T
V
L
V
I
A
H
R
L
S
T
I
K
N
-
A
N
M
V
A
V
L
D
Q
G
K
I
T
E
Y
G
K
H
E
E
-----------------------------------------------------------------------------------------------------------------------------