@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3671c: (2016-05-22 )
MTPSQWLDIAVLAVAFIAAISGWRAGALGSMLSFGGVLLGATAGVLLAPHIVSQISAPRAKLFAALFLILALVVVGEVAGVVLGRAVRGAIRNRPIRLIDSVIGVGVQLVVVLTAAWLLAMPLTQSKEQPELAAAVKGSRVLARVNEAAPTWLKTVPKRLSALLNTSGLPAVLEPFSRTPVIPVASPDPALVNNPVVAATEPSVVKIRSLAPRCQKVLEGTGFVISPDRVMTNAHVVAGSNNVTVYAGDKPFEATVVSYDPSVDVAILAVPHLPPPPLVFAAEPAKTGADVVVLGYPGGGNFTATPARIREAIRLSGPDIYGDPEPVTRDVYTIRADVEQGDSGGPLIDLNGQVLGVVFGAAIDDAETGFVLTAGEVAGQLAKIGATQPVGTGACVS
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.-----------------------.----------.---------.----....-----220....--.-.--.230.......240-.-----------.......-----.--250.--.....-..260.......270---..-------------......280.-......290.......300...----.....310.......320-.......330.......340.......350.....---..360..------.....370-.........380....-...390.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
T
P
S
Q
W
L
D
I
A
V
L
A
V
A
F
I
A
A
I
SGWRAG
A
L
G
S
M
L
S
F
G
G
V
L
L
GAT
A
G
V
L
L
A
P
H
I
V
S
Q
ISA
P
R
A
K
L
F
A
A
L
F
L
I
L
A
L
V
V
V
G
E
V
A
G
V
V
L
G
R
A
V
R
G
A
IRNR
P
I
R
L
I
D
S
V
I
G
V
G
V
Q
L
V
V
V
L
T
A
A
W
L
L
AMPLTQSKEQ
P
E
L
A
A
A
VKG
S
R
V
L
A
R
V
NEAA
P
T
W
L
K
T
V
P
K
R
L
S
A
L
LNTSG
L
P
A
V
L
EPFSRT
P
V
I
PVASPDPALVNNPVVAATEP
S
V
V
K
I
R
S
L
A
-
P
-----------------------
R
----------
C
---------
Q
----
K
V
LE-----GT
G
F
V
IS--P-D--
R
V
M
T
N
A
H
V
V
AGS---N-----------
N
V
T
V
Y
AG-----D--KP-
F
--
E
A
T
V
V
-SYDPSV
D
V
A
I
L
AVP----HL-------------PPP
P
L
V
F
AAE-PAKTGA
D
V
V
V
L
G
YPGGGN-FTA----
T
P
A
R
I
R
E
A
I
RLSGPDIYG-DPEPVT
R
D
V
Y
T
I
R
A
D
VEQGDSGG
P
L
I
DLN
G
Q
V
L
G
V
---
V
FGAAID------DAET
G
F
---
V
L
T
A
G
E
V
A
G
Q
L
A
KIGA-TQPVGTGACVS
1
PsiBlast_PDB
99.35
100%
-107
- C4 -
3K6Y
-
Y3671_MYCTU
A:
[171-397]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
L
E
P
F
S
R
T
P
V
I
P
V
A
S
P
D
P
A
L
V
N
N
P
V
V
A
A
T
E
P
S
V
V
K
I
R
S
L
A
-
P
-----------------------
R
----------
C
---------
Q
----
K
V
L
E
-----
G
T
G
F
V
I
S
--
P
-
D
--
R
V
M
T
N
A
H
V
V
A
G
S
---
N
-----------
N
V
T
V
Y
A
G
-----
D
--
K
P
-
F
--
E
A
T
V
V
-
S
Y
D
P
S
V
D
V
A
I
L
A
V
P
----
H
L
-------------
P
P
P
P
L
V
F
A
A
E
-
P
A
K
T
G
A
D
V
V
V
L
G
Y
P
G
G
G
N
-
F
T
A
----
T
P
A
R
I
R
E
A
I
R
L
S
G
P
D
I
Y
G
-
D
P
E
P
V
T
R
D
V
Y
T
I
R
A
D
V
E
Q
G
D
S
G
G
P
L
I
D
L
N
G
Q
V
L
G
V
---
V
F
G
A
A
I
D
------
D
A
E
T
G
F
---
V
L
T
A
G
E
V
A
G
Q
L
A
K
I
G
A
-
T
Q
P
V
G
T
G
A
C
V
S
49
HHSearch
98.67
99%
-108
- C4 -
3K6Y
-
Y3671_MYCTU
A:
[171-397]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
V
L
E
P
F
S
R
T
P
V
I
P
V
A
S
P
D
P
A
L
V
N
N
P
V
V
A
A
T
E
P
S
V
V
K
I
R
S
L
A
-
P
-----------------------
R
----------
C
---------
Q
----
K
V
L
E
-----
G
T
G
F
V
I
S
--
P
-
D
--
R
V
M
T
N
A
H
V
V
A
G
S
---
N
-----------
N
V
T
V
Y
A
G
-----
D
--
K
P
-
F
--
E
A
T
V
V
-
S
Y
D
P
S
V
D
V
A
I
L
A
V
P
----
H
L
-------------
P
P
P
P
L
V
F
A
A
E
-
P
A
K
T
G
A
D
V
V
V
L
G
Y
P
G
G
G
N
-
F
T
A
----
T
P
A
R
I
R
E
A
I
R
L
S
G
P
D
I
Y
G
D
P
E
-
P
V
T
R
D
V
Y
T
I
R
A
D
V
E
Q
G
D
S
G
G
P
L
I
D
L
N
G
Q
V
L
G
V
---
V
F
G
A
A
I
D
------
D
A
E
T
G
F
---
V
L
T
A
G
E
V
A
G
Q
L
A
K
I
G
A
-
T
Q
P
V
G
T
G
A
C
V
S
3
PsiBlast_PDB
91.85
99%
-114
- C4 -
3LT3
-
Y3671_MYCTU
A:
[181-391]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
I
P
V
A
S
P
D
P
A
L
V
N
N
P
V
V
A
A
T
E
P
S
V
V
K
I
R
S
L
-----------------------------------------------------
V
L
E
-----
G
T
G
F
V
I
S
--
P
-
D
--
R
V
M
T
N
A
H
V
V
A
G
S
---
N
-----------
N
V
T
V
Y
A
G
-----
D
--
K
P
-
F
--
E
A
T
V
V
-
S
Y
D
P
S
V
D
V
A
I
L
A
V
P
----
H
L
-------------
P
P
P
P
L
V
F
A
A
E
-
P
A
K
T
G
A
D
V
V
V
L
G
Y
P
G
G
G
N
-
F
T
A
----
T
P
A
R
I
R
E
A
I
R
L
S
G
P
D
I
Y
G
-
D
P
E
P
V
T
R
D
V
Y
T
I
R
A
D
V
E
Q
G
D
A
G
G
P
L
I
D
L
N
G
Q
V
L
G
V
---
V
F
G
A
A
I
D
------
D
A
E
T
G
F
---
V
L
T
A
G
E
V
A
G
Q
L
A
K
I
G
A
-
T
Q
P
V
G
------
2
PsiBlast_PDB
91.21
100%
-111
- C4 -
3K6Z
-
Y3671_MYCTU
A:
[182-386]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
P
V
A
S
P
D
P
A
L
V
N
N
P
V
V
A
A
T
E
P
S
V
V
K
I
R
S
L
------------------------------------------------------
L
E
-----
G
T
G
F
V
I
S
--
P
-
D
--
R
V
M
T
N
A
H
V
V
A
G
S
---
N
-----------
N
V
T
V
Y
A
G
-----
D
--
K
P
-
F
--
E
A
T
V
V
-
S
Y
D
P
S
V
D
V
A
I
L
A
V
P
----
H
L
-------------
P
P
P
P
L
V
F
A
A
E
-
P
A
K
T
G
A
D
V
V
V
L
G
Y
P
G
G
G
N
-
F
T
A
----
T
P
A
R
I
R
E
A
I
R
L
S
G
P
D
I
Y
G
-
D
P
E
P
V
T
R
D
V
Y
T
I
R
A
D
V
E
Q
G
D
S
G
G
P
L
I
D
L
N
G
Q
V
L
G
V
---
V
F
G
A
A
I
D
------
D
A
E
T
G
F
---
V
L
T
A
G
E
V
A
G
Q
L
A
K
I
G
A
------------
21
PsiBlast_CBE
70.26
32%
-82
- C4 -
3QO6
2
DEGP1_ARATH
C:
[28-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
V
V
Y
I
T
N
L
A
-
V
-----------------------
R
----------
Q
---------
D
AFTL
D
V
L
E
VPQGS
G
S
G
F
V
W
D
--
K
-
Q
G-
H
I
V
T
N
Y
H
V
I
R
G
A
---
S
-----------
D
L
R
V
T
L
A
-----
D
--
Q
T
T
F
--
D
A
K
V
V
-
G
F
D
Q
D
K
D
V
A
V
L
R
I
D
APKN
K
L
-------------
R
P
I
P
V
G
V
S
A
D
--
L
L
V
G
Q
K
V
F
A
I
G
N
P
F
G
L
D
-
H
T
L
----
T
T
G
V
I
S
G
L
R
R
E
I
S
S
A
A
T
G
-
R
P
---
I
Q
D
V
I
Q
T
D
A
A
I
N
P
G
N
S
G
G
P
L
L
D
S
S
G
T
L
I
G
I
NTA
I
Y
S
P
S
G
A
------
S
S
G
V
G
F
SIP
V
D
T
V
G
G
I
V
D
Q
L
V
R
F
G
K
V
T
R
P
I
-------
22
PsiBlast_CBE
69.81
32%
-82
- C4 -
3QO6
3
DEGP1_ARATH
B:
[28-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
V
V
Y
I
T
N
L
A
-
V
-----------------------
R
----------
Q
---------
D
AFTL
D
V
L
E
V
P
Q
G
S
G
S
G
F
V
W
D
--
K
-
Q
G-
H
I
V
T
N
Y
H
V
I
R
G
A
---
S
-----------
D
L
R
V
T
L
A
-----
D
--
Q
T
T
F
--
D
A
K
V
V
-
G
F
D
Q
D
K
D
V
A
V
L
R
I
D
APKN
K
L
-------------
R
P
I
P
V
G
V
S
A
D
--
L
L
V
G
Q
K
V
F
A
I
G
N
P
F
G
L
D
-
H
T
L
----
T
T
G
V
I
S
G
L
R
R
E
I
S
S
A
A
T
G
-
R
P
---
I
Q
D
V
I
Q
T
D
A
A
I
N
P
G
N
S
G
G
P
L
L
D
S
S
G
T
L
I
G
I
N
T
A
I
Y
S
P
S
G
A
------
S
S
G
V
G
F
S
IP
V
D
T
V
G
G
I
V
D
Q
L
V
R
F
G
K
V
T
R
P
I
-------
4
PsiBlast_PDB
69.28
32%
-81
- C4 -
3QO6
2
DEGP1_ARATH
A:
[28-234]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
S
V
V
Y
I
T
N
L
A
-
V
-----------------------
R
----------
Q
---------
D
AFTL
D
V
L
E
V
P
Q
G
S
G
S
G
F
V
W
D
--
K
-
Q
G-
H
I
V
T
N
Y
H
V
I
R
G
A
---
S
-----------
D
L
R
V
T
L
A
-----
D
--
Q
T
T
F
--
D
A
K
V
V
-
G
F
D
Q
D
K
D
V
A
V
L
R
I
D
A
P
KN
K
L
-------------
R
P
I
P
V
G
V
S
A
D
--
L
L
V
G
Q
K
V
F
A
I
G
N
P
F
G
L
D
-
H
T
L
----
T
T
G
V
I
S
G
L
R
R
E
I
S
S
A
A
T
G
-
R
P
---
I
Q
D
V
I
Q
T
D
A
A
I
N
P
G
N
S
G
G
P
L
L
D
S
S
G
T
L
I
G
I
NTA
I
Y
S
P
S
G
A
------
S
S
G
V
G
F
S
I
P
V
D
T
V
G
G
I
V
D
Q
L
V
R
F
G
K
V
T
R
P
I
-------
57
HHSearch
65.57
27%
-90
- C4 -
1L1J
-
?
A:
[29-250]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
V
N
V
V
E
A
C
A
P
A
V
V
K
I
D
V
V
K
-
T
TSFFD
P
Y
F
E
Q
F
F
K
K
WFGELPPGF
E
----------
R
---------
Q
----
V
A
S
L
-----
G
S
G
F
I
F
D
--
P
-
E
G-
Y
I
L
T
N
Y
H
V
V
G
G
A
---
D
-----------
N
I
T
V
T
M
L
D----
G
--
S
K
-
Y
--
D
A
E
Y
I
-
G
G
D
E
E
L
D
I
A
V
I
K
I
K
----
A
S
D
K
-----------
K
F
P
Y
L
E
F
G
D
S
D
K
V
K
I
G
E
W
A
I
A
I
G
N
P
L
G
F
Q
-
H
T
V
----
T
V
G
V
V
S
A
T
N
R
R
I
P
--
K
P
D
-
G
S
-
G
Y
Y
V
G
L
I
Q
T
D
A
A
I
N
P
G
N
S
G
G
P
L
L
N
I
H
G
E
V
I
G
I
---
N
T
A
I
V
N
P
QE----
A
V
N
L
G
F
---
A
I
P
I
N
T
V
K
K
F
L
D
T
I
L
-------------
64
HHSearch
63.89
28%
-76
- C4 -
3QO6
2
DEGP1_ARATH
A:
[19-225]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
V
R
L
F
Q
E
N
T
P
S
V
V
Y
I
T
N
L
A
-
V
-----------------------
R
----------
Q
DAFTL
D
V
L
E
V
----
P
Q
G
S
-----
G
S
G
F
V
W
D
--
K
-
Q
G-
H
I
V
T
N
Y
H
V
I
R
G
A
---
S
-----------
D
L
R
V
T
L
A
D----
Q
--
T
T
-
F
--
D
A
K
V
V
-
G
F
D
Q
D
K
D
V
A
V
L
R
I
D
----
A
P
KN-----------
K
L
R
P
I
P
V
G
V
S
A
D
L
L
V
G
Q
K
V
F
A
I
G
N
P
F
G
L
D
-
H
T
L
----
T
T
G
V
I
S
G
L
R
R
E
I
S
S
--
A
A
-
T
G
-
R
P
I
Q
D
V
I
Q
T
D
A
A
I
N
P
G
N
S
G
G
P
L
L
D
S
S
G
T
L
I
G
I
---
N
T
A
I
Y
S
P
SGA---
S
S
G
V
G
F
---
S
I
P
V
D
T
V
G
G
I
V
D
Q
L
V
-------------
60
HHSearch
62.03
22%
-92
- C4 -
1TE0
-
DEGS_ECOLI
A:
[47-249]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
L
A
V
R
R
A
A
P
A
V
V
N
V
Y
N
R
G
-
L
-----------------------
N
TNSHNQ----
L
---------
E
----
I
R
T
L
-----
G
S
G
V
I
M
D
--
Q
-
R
G
-
Y
I
I
T
N
K
H
V
I
N
D
A
---
D
-----------
Q
I
I
V
A
L
Q
D----
G
--
R
V
-
F
--
E
A
L
L
V
-
G
S
D
S
L
T
D
L
A
V
L
I
I
K
----
A
T
G------------
G
L
P
T
I
P
I
N
A
R
R
V
P
H
I
G
D
V
V
L
A
I
G
N
P
Y
N
L
G
-
Q
T
I
----
T
Q
G
I
I
S
A
T
G
R
I
G
----
L
--
N
P
-
T
G
R
Q
N
F
L
Q
T
D
A
S
I
N
H
G
N
S
G
G
A
L
V
N
S
L
G
E
L
M
G
I
---
N
T
L
S
F
D
K
SNDGET
P
E
G
I
G
F
---
A
I
P
F
Q
L
A
T
K
I
M
D
K
L
I
-------------
66
HHSearch
61.73
27%
-82
- C4 -
4FLN
-
DEGP2_ARATH
A:
[44-244]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
S
F
L
N
A
V
V
K
V
Y
C
T
H
-
T
-----------------------
A
P
DYSLPWQK
Q
R
---------
Q
----
F
T
S
T
-----
G
S
A
F
M
I
G
--
D
-
G
--
K
L
L
T
N
A
H
C
V
E
H
D
---
T
-----------
Q
V
K
V
K
R
R
GD---
D
--
R
K
-
Y
--
V
A
K
V
L
-
V
R
G
V
D
C
D
I
A
L
L
S
V
E
----
S
E
DFWK---------
G
A
E
P
L
R
L
G
H
--
L
P
R
L
Q
D
S
V
T
V
V
G
Y
P
L
G
G
D
T
I
S
V
----
T
K
G
V
V
S
R
I
E
V
T
S
----
Y
A
-
H
G
-
S
S
D
L
L
G
I
Q
I
D
A
A
I
N
P
G
N
S
G
G
P
A
F
N
D
Q
G
E
C
I
G
V
---
A
F
Q
V
Y
---------
E
N
I
G
Y
---
V
I
P
T
T
V
V
S
H
F
L
T
D
Y
E
-------------
61
HHSearch
60.15
28%
-92
- C4 -
3TJO
5
HTRA1_HUMAN
A:
[33-229]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
D
V
V
E
K
I
A
P
A
V
V
H
I
E
L
F
R
-
K
L
PFSK------------------
R
----------
E
---------
V
----
P
V
A
S
-----
G
S
G
F
I
V
S
--
E
-
D
G
-
L
I
V
T
N
A
H
V
V
T
N
K
---
H
-----------
R
V
K
V
E
L
K
N----
G
--
A
T
-
Y
--
E
A
K
I
K
-
D
V
D
E
K
A
D
I
A
L
I
K
I
D
----
H
Q
G
------------
K
L
P
V
L
L
L
G
R
S
S
E
L
R
P
G
E
F
V
V
A
I
G
S
P
F
S
L
Q
-
N
T
V
----
T
T
G
I
V
S
T
T
Q
-----------------
D
Y
I
Q
T
D
A
I
I
N
Y
G
N
A
G
G
P
L
V
N
L
D
G
E
V
I
G
I
---
N
T
L
K
V
T
--------
A
G
I
S
F
---
A
I
P
S
D
K
I
K
K
F
L
T
E
S
H
-------------
70
HHSearch
59.79
24%
-97
- C4 -
2AS9
3
SPLC_STAA8 (first)
A:
[22-202]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
F
K
D
-----
A
T
G
F
V
I
G
--
K
-
N
--
T
I
I
T
N
K
H
V
S
K
D
Y
KVG
D
-----------
R
I
T
A
H
P
N
GDKGN
G
--
G
I
-
Y
--
K
I
K
S
I
S
D
Y
P
G
D
E
D
I
S
V
M
N
I
E
----
E
Q
AVERGPKGFN
F
N
E
N
V
Q
A
F
N
F
A
K
--
D
A
K
V
D
D
K
I
K
V
I
G
Y
P
L
P
A
Q
-
N
S
F
K
Q
F
E
S
T
G
T
I
K
----------------
R
I
K
D
N
I
L
N
F
D
A
Y
I
E
P
G
N
S
G
S
P
V
L
N
S
N
N
E
V
I
G
V
---
V
Y
G
G
I
G
K
IG----
S
E
Y
N
G
A
---
V
Y
F
T
P
Q
I
K
D
F
I
Q
K
H
I
-------------
53
HHSearch
59.30
24%
-84
- C4 -
4IC6
-
DEGP8_ARATH
A:
[118-337]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
I
V
Q
L
F
E
K
N
T
Y
S
V
V
N
I
F
D
V
T
-
L
-----------------------
R
P--------------------------
G
N
-----
G
S
G
V
V
W
D
--
G
-
Q
G-
Y
I
V
T
N
Y
H
V
I
G
N
A
---
L
S
R
NPSPGDVV
G
R
V
N
I
L
A
S
D----
G
V
Q
K
N
-
F
--
E
G
K
L
V
-
G
A
D
R
A
K
D
L
A
V
L
K
V
D
----
A
P
ET-----------
L
L
K
P
I
K
V
G
Q
S
N
S
L
K
V
G
Q
Q
C
L
A
I
G
N
P
F
G
F
D
-
H
T
L
----
T
V
G
V
I
S
G
L
N
R
D
I
F
---
S
Q
-
T
G
-
V
T
I
G
G
G
I
Q
T
D
A
A
I
N
P
G
N
A
G
G
P
L
L
D
S
K
G
N
L
I
G
I
---
N
T
A
I
F
T
Q
TGT---
S
A
G
V
G
F
---
A
I
P
S
S
T
V
L
K
I
V
P
Q
L
I
-------------
51
HHSearch
58.46
22%
-81
* C4 *
3STJ
1
DEGQ_ECOLI
A:
[15-232]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
P
M
L
E
K
V
L
P
A
V
V
S
V
R
V
E
G
-
T
----------------------------------
Q
---------
P
----
F
E
G
L
-----
G
S
G
V
I
I
N
AS
K
-
G
--
Y
V
L
T
N
N
H
V
I
N
Q
A
---
Q
-----------
K
I
S
I
Q
L
N
D----
G
--
R
E
-
F
--
D
A
K
L
I
-
G
S
D
D
Q
S
D
I
A
L
L
Q
I
Q
----
N
P
S------------
K
L
T
Q
I
A
I
A
D
S
D
K
L
R
V
G
D
F
A
V
A
V
G
N
P
F
G
L
G
-
Q
T
A
----
T
S
G
I
V
S
A
L
G
R
S
G
L
------
N
L
-
E
G
L
E
N
F
I
Q
T
D
A
S
I
N
R
G
N
S
G
G
A
L
L
N
L
N
G
E
L
I
G
I
---
N
T
A
I
L
A
P
GGG---
S
V
G
I
G
F
---
A
I
P
S
N
M
A
R
T
L
A
Q
Q
L
I
-------------
67
HHSearch
58.05
28%
-94
- C4 -
3NUM
-
HTRA1_HUMAN
A:
[172-368]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
A
D
V
V
E
K
I
A
P
A
V
V
H
I
E
L
F
R
-
K
L
PFSK------------------
R
----------
E
---------
V
----
P
V
A
S
-----
G
S
G
F
I
V
S
--
E
-
D
G
-
L
I
V
T
N
A
H
V
V
T
N
K
---
H
-----------
R
V
K
V
E
L
K
N----
G
--
A
T
-
Y
--
E
A
K
I
K
-
D
V
D
E
K
A
D
I
A
L
I
K
I
D
----
H
Q
G
------------
K
L
P
V
L
L
L
G
R
S
S
E
L
R
P
G
E
F
V
V
A
I
G
S
------
N
T
V
----
T
T
G
I
V
S
T
T
------------------
D
Y
I
Q
T
D
A
I
I
N
Y
G
N
A
G
G
P
L
V
N
L
D
G
E
V
I
G
I
---
N
T
L
K
V
T
--------
A
G
I
S
F
---
A
I
P
S
D
K
I
K
K
F
L
T
E
S
H
-------------
62
HHSearch
57.98
25%
-83
- C4 -
4IC5
1
DEGP5_ARATH
A:
[42-264]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
N
V
N
L
F
Q
K
T
S
P
S
V
V
Y
I
E
A
I
E
L---------------------------------------------------
E
G
T
-----
G
S
G
F
V
W
D
--
K
L
G
--
H
I
V
T
N
Y
H
V
I
A
K
L
---
A
TDQFGL
Q
----
R
C
K
V
S
L
V
D
AK--
G
--
T
R
-
F
S
K
E
G
K
I
V
-
G
L
D
P
D
N
D
L
A
V
L
K
I
E
----
T
E
G
R
-----------
E
L
N
P
V
V
L
G
T
S
N
D
L
R
V
G
Q
S
C
F
A
I
G
N
P
Y
G
Y
E
-
N
T
L
----
T
I
G
V
V
S
G
L
G
R
E
I
P
---
S
P
-
N
G
-
K
S
I
S
E
A
I
Q
T
D
A
D
I
N
S
G
N
A
G
G
P
L
L
D
S
Y
G
H
T
I
G
V
---
N
T
A
T
F
-----------
V
N
F
---
A
I
P
I
D
T
V
V
R
T
V
P
Y
L
I
-------------
56
HHSearch
57.83
22%
-90
- C4 -
3LGI
2
DEGS_ECOLI
A:
[22-224]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
N
L
A
V
R
R
A
A
P
A
V
V
N
V
Y
N
R
G
-
L
-----------------------
N
TNSHN
Q
----
L
---------
E
----
I
R
T
L
-----
G
S
G
V
I
M
D
--
Q
-
R
G-
Y
I
I
T
N
K
H
V
I
N
D
A
---
D
-----------
Q
I
I
V
A
L
Q
D----
G
--
R
V
-
F
--
E
A
L
L
V
-
G
S
D
S
L
T
D
L
A
V
L
K
I
N
----
A
T
G
------------
G
L
P
T
I
P
I
N
A
R
R
V
P
H
I
G
D
V
V
L
A
I
G
N
P
Y
N
L
G
-
Q
T
I
----
T
Q
G
I
I
S
A
T
G
R
I
G
L
---
N
---
P
-
T
G
R
Q
N
F
L
Q
T
D
A
S
I
N
H
G
N
S
G
G
A
L
V
N
S
L
G
E
L
M
G
I
---
N
T
L
S
F
D
K
SNDG
E
T
P
E
G
I
G
F
---
A
I
P
F
Q
L
A
T
K
I
M
D
K
L
I
-------------
59
HHSearch
57.40
23%
-94
- C4 -
3PV2
-
?
A:
[9-238]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
A
P
V
L
K
N
I
M
P
A
I
V
N
V
A
V
Q
G
-
Y
L
P
N-------------------------------
R
---------
K
----
F
E
S
I
-----
G
S
G
V
I
I
D
--
P
-
N
NG
V
I
I
T
N
D
H
V
I
R
N
A
---
S
-----------
L
I
T
V
T
L
Q
D----
G
--
R
R
-
L
--
K
A
R
L
I
-
G
G
D
S
E
T
D
L
A
V
L
K
I
D
----
A
K
-------------
N
L
K
S
L
V
I
G
D
S
D
K
L
E
V
G
D
F
V
V
A
I
G
N
P
F
G
L
-S
Q
S
A
----
T
F
G
I
V
S
A
L
K
-----------------
N
F
I
Q
T
D
A
A
I
N
P
G
N
S
G
G
A
L
V
N
A
K
G
E
L
I
G
I
---
N
T
A
I
L
---------
V
G
I
G
F
---
A
I
P
I
N
M
V
K
D
V
A
Q
Q
I
I
-------------
52
HHSearch
56.01
22%
-95
- C4 -
3STI
-
DEGQ_ECOLI
A:
[15-232]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
A
P
M
L
E
K
V
L
P
A
V
V
S
V
----------------------------------------------------------
L
-----
G
S
G
V
I
I
N
AS
K
-
G
--
Y
V
L
T
N
N
H
V
I
------------------
K
I
S
I
Q
L
N
D----
G
--
R
E
-
F
--
D
A
K
L
I
-
G
S
D
D
Q
S
D
I
A
L
L
Q
I
Q
----
N
P
S------------
K
L
T
Q
I
A
I
A
D
S
D
K
L
R
V
G
D
F
A
V
A
V
G
N
P
F
G
L
G
-
Q
T
A
----
T
S
G
I
V
S
A
L
G
R
S
G
L
------
N
L
-
E
G
L
E
N
F
I
Q
T
D
A
S
I
N
R
G
N
S
G
G
A
L
L
N
L
N
G
E
L
I
G
I
---
N
T
A
I
L
---------
V
G
I
G
F
---
A
I
P
S
N
M
A
R
T
L
A
Q
Q
L
I
-------------