@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3710: (2016-05-22 )
MPVNRYRPFAEEVEPIRLRNRTWPDRVIDRAPLWCAVDLRDGNQALIDPMSPARKRRMFDLLVRMGYKEIEVGFPSASQTDFDFVREIIEQGAIPDDVTIQVLTQCRPELIERTFQACSGAPRAIVHFYNSTSILQRRVVFRANRAEVQAIATDGARKCVEQAAKYPGTQWRFEYSPESYTGTELEYAKQVCDAVGEVIAPTPERPIIFNLPATVEMTTPNVYADSIEWMSRNLANRESVILSLHPHNDRGTAVAAAELGFAAGADRIEGCLFGNGERTGNVCLVTLGLNLFSRGVDPQIDFSNIDEIRRTVEYCNQLPVHERHPYGGDLVYTAFSGSHQDAINKGLDAMKLDADAADCDVDDMLWQVPYLPIDPRDVGRTYEAVIRVNSQSGKGGVAYIMKTDHGLSLPRRLQIEFSQVIQKIAEGTAGEGGEVSPKEMWDAFAEEYLAPVRPLERIRQHVDAADDDGGTTSITATVKINGVETEISGSGNGPLAAFVHALADVGFDVAVLDYYEHAMSAGDDAQAAAYVEASVTIASPAQPGEAGRHASDPVTIASPAQPGEAGRHASDPVTSKTVWGVGIAPSITTASLRAVVSAVNRAAR
Atome Classification :
(20 SA)
----------------------.-........10........20........30........40........50.-.......-60.-...-....70........80-----.........90.---.......100.......110.......120.......130.......140.......150.......160.......170...---....180--..--......190.......200.......210.....-..220.......-230.......240.......250.......260.......270.....------..280.......290.----.---.---....300.......310.......320.......330.......340.......-350.......360-.......370.......380.......-390.......400........410.......420.......430.......-440.......450.......460.......470.......480.......490.......500.......510.......-520.......530.......540.......550.......560.......570.......580.......590.......600..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----------------------M-PVNRYR
P
F
A
EEVE
P
I
RLRNRT
W
P
D
R
VIDRAP
L
W
C
A
V
DLRDG
N
Q
A
LIDPMS
P
-
A
R
K
R
R
M
F
-
D
L
L
-
V
RM-GY
K
E
I
E
VGFPSASQT------
D
F
D
F
V
R
E
I
I
EQG---AIPD
D
V
T
I
Q
V
L
T
QC
R
P
E
L
I
E
R
T
F
Q
A
CSGAP
R
A
I
V
H
FYN
S
T
S
I
L
Q
R
R
V
V
FRAN
R
A
E
V
Q
AIA
T
D
G
A
R
K
C
V
E
Q
A
AKYPGT
Q
W
R
F
E
Y---SPESYT---G
T
--
E
L
E
Y
A
K
Q
V
C
D
A
V
G
E
V
IAPTPER
P
I
I
F
NLP
A
T
V
E
M-TTPNV
Y
A
D
S
I
E
W
-
M
S
R
NLANR
E
S
V
I
L
S
LHPHNDRG
T
A
V
A
A
A
E
LGFAA
G
A
D
R
I
E
G
C
L
FGNGE------RTG
N
V
C
L
V
TL
G
L
N
L
F
S----R---G---VDPQIDFS
N
I
D
E
I
R
R
T
V
E
Y
C
N
QLPVHERHPYGG
D
L
V
Y
T
AFSGS
H
Q
D
A
I
N
KGL
D
A
-
M
KLDADAADC
D
V
D
-
D
M
L
W
QVPYLPI
D
P
R
D
V
G
R
T
Y
E
A
V
I
R
V
N-SQSGKG
G
V
A
Y
I
M
-KTDHGLSL
P
R
R
L
Q
I
E
F
S
Q
V
I
Q
K
I
AEGTAGEGGEV
S
P
K
E
-
M
W
D
A
F
A
E
E
YLAPV
R
P
L
E
R
I
R
Q
H
VDAADDDGG
T
T
S
I
T
A
T
V
K
IN
G
V
E
T
E
ISGSGN
G
P
L
A
A
F
V
H
A
L
A
DVGF
D
V
A
V
L
D
Y
Y
E
H
A
M-SAGDD
A
Q
A
A
A
Y
V
E
A
S
V
T
IASPAQPGEAGRHASD
P
V
T
IASPAQPGEAGRHASDPVTSK
T
V
W
GVGIAP
S
I
T
T
A
S
L
R
A
V
V
S
A
V
N
RAAR
24
PsiBlast_CBE
99.03
100%
-109
* C2 *
3HPS
6
LEU1_MYCTU
B:
[41-644]
----------------------
M
-
P
V
N
R
Y
R
P
F
A
E
E
V
E
P
I
-
L
R
N
R
T
W
P
D
R
V
I
D
R
A
P
L
W
C
A
V
D
L
R
D
G
N
Q
A
L
I
D
P
M
S
P
-
A
R
K
R
R
M
F
-
D
L
L
-
V
R
M
-
G
Y
K
E
I
E
V
G
F
P
S
A
S
Q
T
------
D
F
D
F
V
R
E
I
I
E
Q
G
---
A
I
P
D
D
V
T
I
Q
V
L
T
Q
C
R
P
E
L
I
E
R
T
F
Q
A
C
S
G
A
P
R
A
I
V
H
F
Y
N
S
T
S
I
L
Q
R
R
V
V
F
R
A
N
R
A
E
V
Q
A
I
A
T
D
G
A
R
K
C
V
E
Q
A
A
K
Y
P
G
T
Q
W
R
F
E
Y
---
S
P
E
S
Y
T
---
G
T
--
E
L
E
Y
A
K
Q
V
C
D
A
V
G
E
V
I
A
P
T
P
E
R
P
I
I
F
N
L
P
A
T
V
E
M
-
T
T
P
N
V
Y
A
D
S
I
E
W
-
M
S
R
N
L
A
N
R
E
S
V
I
L
S
L
H
P
H
N
D
R
G
T
A
V
A
A
A
E
L
G
F
A
A
G
A
D
R
I
E
G
C
L
F
G
N
G
E
------
R
T
G
N
V
C
L
V
T
L
G
L
N
L
F
S
----
R
---
G
---
V
D
P
Q
I
D
F
S
N
I
D
E
I
R
R
T
V
E
Y
C
N
Q
L
P
V
H
E
R
H
P
Y
G
G
D
L
V
Y
T
A
F
S
G
S
H
Q
D
A
I
N
K
G
L
D
A
-
M
K
L
D
A
D
A
A
D
C
D
V
D
-
D
M
L
W
Q
V
P
Y
L
P
I
D
P
R
D
V
G
R
T
Y
E
A
V
I
R
V
N
-----
K
G
G
V
A
Y
I
M
-
K
T
D
H
G
L
S
L
P
R
R
L
Q
I
E
F
S
Q
V
I
Q
K
-----------
V
S
P
K
E
-
M
W
D
A
F
A
E
E
Y
L
A
P
V
R
P
L
E
R
I
R
Q
H
V
D
A
A
D
D
D
G
G
T
T
S
I
T
A
T
V
K
I
N
G
V
E
T
E
I
S
G
S
G
N
G
P
L
A
A
F
V
H
A
L
A
D
V
G
F
D
V
A
V
L
D
Y
Y
E
H
A
M
-
S
A
G
D
D
A
Q
A
A
A
Y
V
E
A
S
V
T
I
A
S
----------------------------------
T
S
K
T
V
W
G
V
G
I
A
P
S
I
T
T
A
S
L
R
A
V
V
S
A
V
N
R
A
A
R
2
PsiBlast_PDB
98.98
100%
-109
- C2 -
3HPS
6
LEU1_MYCTU
A:
[41-643]
----------------------
M
-
P
V
N
R
Y
R
P
F
A
E
E
V
E
P
I
R
L
R
N
R
T
W
P
D
R
V
I
D
R
A
P
L
W
C
A
V
D
L
R
D
G
N
Q
A
L
I
D
P
M
S
P
-
A
R
K
R
R
M
F
-
D
L
L
-
V
R
M
-
G
Y
K
E
I
E
V
G
F
P
S
A
S
Q
T
------
D
F
D
F
V
R
E
I
I
E
Q
G
---
A
I
P
D
D
V
T
I
Q
V
L
T
Q
C
R
P
E
L
I
E
R
T
F
Q
A
C
S
G
A
P
R
A
I
V
H
F
Y
N
S
T
S
I
L
Q
R
R
V
V
F
R
A
N
R
A
E
V
Q
A
I
A
T
D
G
A
R
K
C
V
E
Q
A
A
K
Y
P
G
T
Q
W
R
F
E
Y
---
S
P
E
S
Y
T
---
G
T
--
E
L
E
Y
A
K
Q
V
C
D
A
V
G
E
V
I
A
P
T
P
E
R
P
I
I
F
N
L
P
A
T
V
E
M
-
T
T
P
N
V
Y
A
D
S
I
E
W
-
M
S
R
N
L
A
N
R
E
S
V
I
L
S
L
H
P
H
N
D
R
G
T
A
V
A
A
A
E
L
G
F
A
A
G
A
D
R
I
E
G
C
L
F
G
N
G
E
------
R
T
G
N
V
C
L
V
T
L
G
L
N
L
F
S
----
R
---
G
---
V
D
P
Q
I
D
F
S
N
I
D
E
I
R
R
T
V
E
Y
C
N
Q
L
P
V
H
E
R
H
P
Y
G
G
D
L
V
Y
T
A
F
S
G
S
H
Q
D
A
I
N
K
G
L
D
A
-
M
K
L
D
A
D
A
A
D
C
D
V
D
-
D
M
L
W
Q
V
P
Y
L
P
I
D
P
R
D
V
G
R
T
Y
E
A
V
I
--------
K
G
G
V
A
Y
I
M
-
K
T
D
H
G
L
S
L
P
R
R
L
Q
I
E
F
S
Q
V
I
Q
K
I
---------
E
V
S
P
K
E
-
M
W
D
A
F
A
E
E
Y
L
A
P
V
R
P
L
E
R
I
R
Q
H
V
D
A
A
D
D
D
G
G
T
T
S
I
T
A
T
V
K
I
N
G
V
E
T
E
I
S
G
S
G
N
G
P
L
A
A
F
V
H
A
L
A
D
V
G
F
D
V
A
V
L
D
Y
Y
E
H
A
M
-
S
A
G
D
D
A
Q
A
A
A
Y
V
E
A
S
V
T
I
A
-----------------------------------
T
S
K
T
V
W
G
V
G
I
A
P
S
I
T
T
A
S
L
R
A
V
V
S
A
V
N
R
A
A
-
22
PsiBlast_CBE
98.97
100%
-109
- C2 -
3HQ1
7
LEU1_MYCTU
B:
[41-643]
----------------------
M
-
P
V
N
R
Y
R
P
F
A
E
E
V
E
P
I
R
L
R
N
R
T
W
P
D
R
V
I
D
R
A
P
L
W
C
A
V
D
L
R
D
G
N
Q
A
L
I
D
P
M
S
P
-
A
R
K
R
R
M
F
-
D
L
L
-
V
R
M
-
G
Y
K
E
I
E
V
G
F
P
S
A
S
Q
T
------
D
F
D
F
V
R
E
I
I
E
Q
G
---
A
I
P
D
D
V
T
I
Q
V
L
T
Q
C
R
P
E
L
I
E
R
T
F
Q
A
C
S
G
A
P
R
A
I
V
H
F
Y
N
S
T
S
I
L
Q
R
R
V
V
F
R
A
N
R
A
E
V
Q
A
I
A
T
D
G
A
R
K
C
V
E
Q
A
A
K
Y
P
G
T
Q
W
R
F
E
Y
---
S
P
E
S
Y
T
---
G
T
--
E
L
E
Y
A
K
Q
V
C
D
A
V
G
E
V
I
A
P
T
P
E
R
P
I
I
F
N
L
P
A
T
V
E
M
-
T
T
P
N
V
Y
A
D
S
I
E
W
-
M
S
R
N
L
A
N
R
E
S
V
I
L
S
L
H
P
H
N
D
R
G
T
A
V
A
A
A
E
L
G
F
A
A
G
A
D
R
I
E
G
C
L
F
G
N
G
E
------
R
T
G
N
V
C
L
V
T
L
G
L
N
L
F
S
----
R
---
G
---
V
D
P
Q
I
D
F
S
N
I
D
E
I
R
R
T
V
E
Y
C
N
Q
L
P
V
H
E
R
H
P
Y
G
G
D
L
V
Y
T
A
F
S
G
S
H
Q
D
A
I
N
K
G
L
D
A
-
M
K
L
D
A
D
A
A
D
C
D
V
D
-
D
M
L
W
Q
V
P
Y
L
P
I
D
P
R
D
V
G
R
T
Y
E
A
V
I
R
V
N
-----
K
G
G
V
A
Y
I
M
-
K
T
D
H
G
L
S
L
P
R
R
L
Q
I
E
F
S
Q
V
I
Q
K
-----------
V
S
P
K
E
-
M
W
D
A
F
A
E
E
Y
L
A
P
V
R
P
L
E
R
I
R
Q
H
V
D
A
A
D
D
D
G
G
T
T
S
I
T
A
T
V
K
I
N
G
V
E
T
E
I
S
G
S
G
N
G
P
L
A
A
F
V
H
A
L
A
D
V
G
F
D
V
A
V
L
D
Y
Y
E
H
A
M
-
S
A
G
D
D
A
Q
A
A
A
Y
V
E
A
S
V
T
I
A
-----------------------------------
T
S
K
T
V
W
G
V
G
I
A
P
S
I
T
T
A
S
L
R
A
V
V
S
A
V
N
R
A
A
-
21
PsiBlast_CBE
98.75
100%
-109
- C2 -
3FIG
5
LEU1_MYCTU
B:
[43-646]
----------------------
M
-
P
V
N
R
Y
R
P
F
A
E
E
V
E
P
I
R
L
R
N
R
T
W
P
D
R
V
I
D
R
A
P
L
W
C
A
V
D
L
R
D
G
N
Q
A
L
I
D
P
M
S
P
-
A
R
K
R
R
M
F
-
D
L
L
-
V
R
M
-
G
Y
K
E
I
E
V
G
F
P
S
A
S
Q
T
------
D
F
D
F
V
R
E
I
I
E
Q
G
---
A
I
P
D
D
V
T
I
Q
V
L
T
Q
C
R
P
E
L
I
E
R
T
F
Q
A
C
S
G
A
P
R
A
I
V
H
F
Y
N
S
T
S
I
L
Q
R
R
V
V
F
R
A
N
R
A
E
V
Q
A
I
A
T
D
G
A
R
K
C
V
E
Q
A
A
K
Y
P
G
T
Q
W
R
F
E
Y
---
S
P
E
S
Y
T
---
G
T
--
E
L
E
Y
A
K
Q
V
C
D
A
V
G
E
V
I
A
P
T
P
E
R
P
I
I
F
N
L
P
A
T
V
E
M
-
T
T
P
N
V
Y
A
D
S
I
E
W
-
M
S
R
N
L
A
N
R
E
S
V
I
L
S
L
H
P
H
N
D
R
G
T
A
V
A
A
A
E
L
G
F
A
A
G
A
D
R
I
E
G
C
L
F
G
N
G
E
------
R
T
G
N
V
C
L
V
T
L
G
L
N
L
F
S
----
R
---
G
---
V
D
P
Q
I
D
F
S
N
I
D
E
I
R
R
T
V
E
Y
C
N
Q
L
P
V
H
E
R
H
P
Y
G
G
D
L
V
Y
T
A
F
S
G
S
H
Q
D
A
I
N
K
G
L
D
A
-
M
K
L
D
A
D
A
A
D
C
D
V
D
-
D
M
L
W
Q
V
P
Y
L
P
I
D
P
R
D
V
G
R
T
Y
E
A
V
I
R
V
N
-----
K
G
G
V
A
Y
I
M
-
K
T
D
H
G
L
S
L
P
R
R
L
Q
I
E
F
S
Q
V
I
Q
K
-----------
V
S
P
K
E
-
M
W
D
A
F
A
E
E
Y
L
A
P
V
R
P
L
E
R
I
R
Q
H
V
D
A
A
D
D
D
G
G
T
T
S
I
T
A
T
V
K
I
N
G
V
E
T
E
I
S
G
S
G
N
G
P
L
A
A
F
V
H
A
L
A
D
V
G
F
D
V
A
V
L
D
Y
Y
E
H
A
M
-
S
A
G
D
D
A
Q
A
A
A
Y
V
E
A
S
V
T
I
A
-----------------------------------
T
S
K
T
V
W
G
V
G
I
A
P
S
I
T
T
A
S
L
R
A
V
V
S
A
V
N
R
A
A
R
23
PsiBlast_CBE
98.65
100%
-108
- C2 -
3HPZ
6
LEU1_MYCTU
B:
[41-643]
----------------------
M
-
P
V
N
R
Y
R
P
F
A
E
E
V
E
P
I
R
L
R
N
R
T
W
P
D
R
V
I
D
R
A
P
L
W
C
A
V
D
L
R
D
G
N
Q
A
L
I
D
P
M
S
P
-
A
R
K
R
R
M
F
-
D
L
L
-
V
R
M
-
G
Y
K
E
I
E
V
G
F
P
S
A
S
Q
T
------
D
F
D
F
V
R
E
I
I
E
Q
G
---
A
I
P
D
D
V
T
I
Q
V
L
T
Q
C
R
P
E
L
I
E
R
T
F
Q
A
C
S
G
A
P
R
A
I
V
H
F
Y
N
S
T
S
I
L
Q
R
R
V
V
F
R
A
N
R
A
E
V
Q
A
I
A
T
D
G
A
R
K
C
V
E
Q
A
A
K
Y
P
G
T
Q
W
R
F
E
Y
---
S
P
E
S
Y
T
---
G
T
--
E
L
E
Y
A
K
Q
V
C
D
A
V
G
E
V
I
A
P
T
P
E
R
P
I
I
F
N
L
P
A
T
V
E
M
-
T
T
P
N
V
Y
A
D
S
I
E
W
-
M
S
R
N
L
A
N
R
E
S
V
I
L
S
L
H
P
H
N
D
R
G
T
A
V
A
A
A
E
L
G
F
A
A
G
A
D
R
I
E
G
C
L
F
G
N
G
E
------
R
T
G
N
V
C
L
V
T
L
G
L
N
L
F
S
----
R
---
G
---
V
D
P
Q
I
D
F
S
N
I
D
E
I
R
R
T
V
E
Y
C
N
Q
L
P
V
H
E
R
H
P
Y
G
G
D
L
V
Y
T
A
F
S
G
S
H
Q
D
A
I
N
K
G
L
D
A
-
M
K
L
D
A
D
A
A
D
C
D
V
D
-
D
M
L
W
Q
V
P
Y
L
P
I
D
P
R
D
V
G
R
T
Y
E
A
V
I
R
V
N
-----
K
G
G
V
A
Y
I
M
-
K
T
D
H
G
L
S
L
P
R
R
L
Q
I
E
F
S
Q
V
I
Q
K
-----------
V
S
P
K
E
-
M
W
D
A
F
A
E
E
Y
L
A
P
V
R
P
L
E
R
I
R
Q
H
V
D
A
A
D
D
D
G
G
T
T
S
I
T
A
T
V
K
I
N
G
V
E
T
E
I
S
G
S
G
N
G
P
L
A
A
F
V
H
A
L
A
D
V
G
F
D
V
A
V
L
D
Y
Y
E
H
A
M
-
S
A
G
D
D
A
Q
A
A
A
Y
V
E
A
S
V
T
I
A
-----------------------------------
T
S
K
T
V
W
G
V
G
I
A
P
S
I
T
T
A
S
L
R
A
V
V
S
A
V
N
R
A
A
-
1
PsiBlast_PDB
98.00
100%
-108
- C2 -
3FIG
4
LEU1_MYCTU
A:
[43-645]
----------------------
M
-
P
V
N
R
Y
R
P
F
A
E
E
V
E
P
I
R
L
R
N
R
T
W
P
D
R
V
I
D
R
A
P
L
W
C
A
V
D
L
R
D
G
N
Q
A
L
I
D
P
M
S
P
-
A
R
K
R
R
M
F
-
D
L
L
-
V
R
M
-
G
Y
K
E
I
E
V
G
F
P
S
A
S
Q
T
------
D
F
D
F
V
R
E
I
I
E
Q
G
---
A
I
P
D
D
V
T
I
Q
V
L
T
Q
C
R
P
E
L
I
E
R
T
F
Q
A
C
S
G
A
P
R
A
I
V
H
F
Y
N
S
T
S
I
L
Q
R
R
V
V
F
R
A
N
R
A
E
V
Q
A
I
A
T
D
G
A
R
K
C
V
E
Q
A
A
K
Y
P
G
T
Q
W
R
F
E
Y
---
S
P
E
S
Y
T
---
G
T
--
E
L
E
Y
A
K
Q
V
C
D
A
V
G
E
V
I
A
P
T
P
E
R
P
I
I
F
N
L
P
A
T
V
E
M
-
T
T
P
N
V
Y
A
D
S
I
E
W
-
M
S
R
N
L
A
N
R
E
S
V
I
L
S
L
H
P
H
N
D
R
G
T
A
V
A
A
A
E
L
G
F
A
A
G
A
D
R
I
E
G
C
L
F
G
N
G
E
------
R
T
G
N
V
C
L
V
T
L
G
L
N
L
F
S
----
R
---
G
---
V
D
P
Q
I
D
F
S
N
I
D
E
I
R
R
T
V
E
Y
C
N
Q
L
P
V
H
E
R
H
P
Y
G
G
D
L
V
Y
T
A
F
S
G
S
H
Q
D
A
I
N
K
G
L
D
A
-
M
K
L
D
A
D
A
A
D
C
D
V
D
-
D
M
L
W
Q
V
P
Y
L
P
I
D
P
R
D
V
G
R
T
Y
E
A
V
I
--------
K
G
G
V
A
Y
I
M
-
K
T
D
H
G
L
S
L
P
R
R
L
Q
I
E
F
S
Q
V
I
Q
K
I
---------
E
V
S
P
K
E
-
M
W
D
A
F
A
E
E
Y
L
A
P
V
R
P
L
E
R
I
R
Q
H
V
D
A
A
D
D
D
G
G
T
T
S
I
T
A
T
V
K
I
N
G
V
E
T
E
I
S
G
S
G
N
G
P
L
A
A
F
V
H
A
L
A
D
V
G
F
D
V
A
V
L
D
Y
Y
E
H
A
M
-
S
A
G
D
D
A
Q
A
A
A
Y
V
E
A
S
V
T
I
A
S
------------------------------------
K
T
V
W
G
V
G
I
A
P
S
I
T
T
A
S
L
R
A
V
V
S
A
V
N
R
A
A
-
54
Fugue
92.90
92%
-95
- C2 -
1SR9
3
LEU1_MYCTU
A:
[18-643]
TIVKPAGPPRVGQPSWNP
Q
R
A
S
S
M
P
V
N
R
Y
R
P
F
A
E
E
V
E
P
I
R
L
R
N
R
T
W
P
D
R
V
I
D
R
A
P
L
W
C
A
V
D
L
R
D
G
N
Q
---
A
L
I
D
P
M
S
P
A
R
K
R
R
M
F
D
L
-
L
V
R
M
G
Y
K
E
I
E
V
G
F
P
S
A
S
Q
T
------
D
F
D
F
V
R
E
I
I
E
Q
G
---
A
I
P
D
D
V
T
I
Q
V
L
T
Q
C
R
P
E
L
I
E
R
T
F
Q
A
C
S
G
A
P
R
A
I
V
H
F
Y
N
S
T
S
I
L
Q
R
R
V
V
F
R
A
N
R
A
E
V
Q
A
I
A
T
D
G
A
R
K
C
V
E
Q
A
A
K
Y
P
G
T
Q
W
R
F
E
Y
---
S
P
E
S
Y
T
---
G
T
--
E
L
E
Y
A
K
Q
V
C
D
A
V
G
E
V
I
A
P
T
P
E
R
P
I
I
F
N
L
P
A
T
V
-
E
M
T
T
P
N
V
Y
A
D
S
I
E
W
M
S
-
R
N
L
A
N
R
E
S
V
I
L
S
L
H
P
H
N
D
R
G
T
A
V
A
A
A
E
L
G
F
A
A
G
A
D
R
I
E
G
C
L
F
G
N
G
E
------
R
T
G
N
V
C
L
V
T
L
G
L
N
L
F
S
----
R
---
G
---
V
D
P
Q
I
D
F
S
N
I
D
E
I
R
R
T
V
E
Y
C
N
Q
L
P
V
H
E
R
H
P
Y
G
G
D
L
V
Y
T
A
F
S
G
S
H
Q
D
A
I
N
K
G
L
D
A
M
K
L
D
A
D
A
A
D
C
D
V
D
D
M
L
--
W
Q
V
P
Y
L
P
I
D
P
R
D
V
G
R
T
Y
E
A
V
I
K
G
G
-
V
A
Y
--------
I
M
K
T
D
H
G
L
S
L
P
R
R
L
Q
I
E
F
S
Q
V
I
Q
K
---------
I
E
V
S
P
K
E
M
W
-
D
A
F
A
E
E
Y
L
A
P
V
R
P
L
E
R
I
R
Q
H
V
D
A
A
D
D
D
G
G
T
T
S
I
T
A
T
V
K
I
N
G
V
E
T
E
I
S
G
S
G
N
G
P
L
A
A
F
V
H
A
L
A
D
V
G
F
D
V
A
V
L
D
Y
Y
E
H
A
-M
S
A
G
D
D
A
Q
A
A
A
Y
V
E
A
S
V
T
-------------------------------------
I
S
K
T
V
W
G
V
G
I
A
P
S
I
T
T
A
S
L
R
A
V
V
S
A
V
N
R
A
A
-
25
PsiBlast_CBE
82.16
100%
-97
- C2 -
3HPX
3
LEU1_MYCTU
B:
[41-425]
----------------------
M
-
P
V
N
R
Y
R
P
F
A
E
E
V
E
P
I
R
L
R
N
R
T
W
P
D
R
V
I
D
R
A
P
L
W
C
A
V
D
L
R
D
G
N
Q
A
L
I
D
P
M
S
P
-
A
R
K
R
R
M
F
-
D
L
L
-
V
R
M
-
G
Y
K
E
I
E
V
G
F
P
S
A
S
Q
T
------
D
F
D
F
V
R
E
I
I
E
Q
G
---
A
I
P
D
D
V
T
I
Q
V
L
T
Q
C
R
P
E
L
I
E
R
T
F
Q
A
C
S
G
A
P
R
A
I
V
H
F
Y
N
S
T
S
I
L
Q
R
R
V
V
F
R
A
N
R
A
E
V
Q
A
I
A
T
D
G
A
R
K
C
V
E
Q
A
A
K
Y
P
G
T
Q
W
R
F
E
Y
---
S
P
E
S
Y
T
---
G
T
--
E
L
E
Y
A
K
Q
V
C
D
A
V
G
E
V
I
A
P
T
P
E
R
P
I
I
F
N
L
P
A
T
V
E
M
-
T
T
P
N
V
Y
A
D
S
I
E
W
-
M
S
R
N
L
A
N
R
E
S
V
I
L
S
L
H
P
H
N
D
R
G
T
A
V
A
A
A
E
L
G
F
A
A
G
A
D
R
I
E
G
C
L
F
G
N
G
E
------
R
T
G
N
V
C
L
V
T
L
G
L
N
L
F
S
----
R
---
G
---
V
D
P
Q
I
D
F
S
N
I
D
E
I
R
R
T
V
E
Y
C
N
Q
L
P
V
H
E
R
H
P
Y
G
G
D
L
V
Y
T
A
F
S
G
S
H
Q
D
A
I
N
K
G
L
D
A
-
M
K
L
D
A
D
A
A
D
C
D
V
D
-
D
M
L
W
Q
V
P
Y
L
P
I
D
P
R
D
V
G
R
T
Y
E
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
81.70
100%
-97
- C2 -
3HPX
3
LEU1_MYCTU
A:
[41-425]
----------------------
M
-
P
V
N
R
Y
R
P
F
A
E
E
V
E
P
I
R
L
R
N
R
T
W
P
D
R
V
I
D
R
A
P
L
W
C
A
V
D
L
R
D
G
N
Q
A
L
I
D
P
M
S
P
-
A
R
K
R
R
M
F
-
D
L
L
-
V
R
M
-
G
Y
K
E
I
E
V
G
F
P
S
A
S
Q
T
------
D
F
D
F
V
R
E
I
I
E
Q
G
---
A
I
P
D
D
V
T
I
Q
V
L
T
Q
C
R
P
E
L
I
E
R
T
F
Q
A
C
S
G
A
P
R
A
I
V
H
F
Y
N
S
T
S
I
L
Q
R
R
V
V
F
R
A
N
R
A
E
V
Q
A
I
A
T
D
G
A
R
K
C
V
E
Q
A
A
K
Y
P
G
T
Q
W
R
F
E
Y
---
S
P
E
S
Y
T
---
G
T
--
E
L
E
Y
A
K
Q
V
C
D
A
V
G
E
V
I
A
P
T
P
E
R
P
I
I
F
N
L
P
A
T
V
E
M
-
T
T
P
N
V
Y
A
D
S
I
E
W
-
M
S
R
N
L
A
N
R
E
S
V
I
L
S
L
H
P
H
N
D
R
G
T
A
V
A
A
A
E
L
G
F
A
A
G
A
D
R
I
E
G
C
L
F
G
N
G
E
------
R
T
G
N
V
C
L
V
T
L
G
L
N
L
F
S
----
R
---
G
---
V
D
P
Q
I
D
F
S
N
I
D
E
I
R
R
T
V
E
Y
C
N
Q
L
P
V
H
E
R
H
P
Y
G
G
D
L
V
Y
T
A
F
S
G
S
H
Q
D
A
I
N
K
G
L
D
A
-
M
K
L
D
A
D
A
A
D
C
D
V
D
-
D
M
L
W
Q
V
P
Y
L
P
I
D
P
R
D
V
G
R
T
Y
E
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
81.48
100%
-99
- C2 -
3U6W
4
LEU1_MYCTU
A:
[43-427]
----------------------
M
-
P
V
N
R
Y
R
P
F
A
E
E
V
E
P
I
R
L
R
N
R
T
W
P
D
R
V
I
D
R
A
P
L
W
C
A
V
D
L
R
D
G
N
Q
A
L
I
D
P
M
S
P
-
A
R
K
R
R
M
F
-
D
L
L
-
V
R
M
-
G
Y
K
E
I
E
V
G
F
P
S
A
S
Q
T
------
D
F
D
F
V
R
E
I
I
E
Q
G
---
A
I
P
D
D
V
T
I
Q
V
L
T
Q
C
R
P
E
L
I
E
R
T
F
Q
A
C
S
G
A
P
R
A
I
V
H
F
Y
N
S
T
S
I
L
Q
R
R
V
V
F
R
A
N
R
A
E
V
Q
A
I
A
T
D
G
A
R
K
C
V
E
Q
A
A
K
Y
P
G
T
Q
W
R
F
E
Y
---
S
P
E
S
Y
T
---
G
T
--
E
L
E
Y
A
K
Q
V
C
D
A
V
G
E
V
I
A
P
T
P
E
R
P
I
I
F
N
L
P
A
T
V
E
M
-
T
T
P
N
V
Y
A
D
S
I
E
W
-
M
S
R
N
L
A
N
R
E
S
V
I
L
S
L
H
P
H
N
D
R
G
T
A
V
A
A
A
E
L
G
F
A
A
G
A
D
R
I
E
G
C
L
F
G
N
G
E
------
R
T
G
N
V
C
L
V
T
L
G
L
N
L
F
S
----
R
---
G
---
V
D
P
Q
I
D
F
S
N
I
D
E
I
R
R
T
V
E
Y
C
N
Q
L
P
V
H
E
R
H
P
Y
G
G
D
L
V
Y
T
A
F
S
G
S
H
Q
D
A
I
N
K
G
L
D
A
-
M
K
--------
D
V
D
-
D
M
L
W
Q
V
P
Y
L
P
I
D
P
R
D
V
G
R
T
Y
E
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
PsiBlast_CBE
81.46
100%
-99
- C2 -
3U6W
4
LEU1_MYCTU
B:
[43-427]
----------------------
M
-
P
V
N
R
Y
R
P
F
A
E
E
V
E
P
I
R
L
R
N
R
T
W
P
D
R
V
I
D
R
A
P
L
W
C
A
V
D
L
R
D
G
N
Q
A
L
I
D
P
M
S
P
-
A
R
K
R
R
M
F
-
D
L
L
-
V
R
M
-
G
Y
K
E
I
E
V
G
F
P
S
A
S
Q
T
------
D
F
D
F
V
R
E
I
I
E
Q
G
---
A
I
P
D
D
V
T
I
Q
V
L
T
Q
C
R
P
E
L
I
E
R
T
F
Q
A
C
S
G
A
P
R
A
I
V
H
F
Y
N
S
T
S
I
L
Q
R
R
V
V
F
R
A
N
R
A
E
V
Q
A
I
A
T
D
G
A
R
K
C
V
E
Q
A
A
K
Y
P
G
T
Q
W
R
F
E
Y
---
S
P
E
S
Y
T
---
G
T
--
E
L
E
Y
A
K
Q
V
C
D
A
V
G
E
V
I
A
P
T
P
E
R
P
I
I
F
N
L
P
A
T
V
E
M
-
T
T
P
N
V
Y
A
D
S
I
E
W
-
M
S
R
N
L
A
N
R
E
S
V
I
L
S
L
H
P
H
N
D
R
G
T
A
V
A
A
A
E
L
G
F
A
A
G
A
D
R
I
E
G
C
L
F
G
N
G
E
------
R
T
G
N
V
C
L
V
T
L
G
L
N
L
F
S
----
R
---
G
---
V
D
P
Q
I
D
F
S
N
I
D
E
I
R
R
T
V
E
Y
C
N
Q
L
P
V
H
E
R
H
P
Y
G
G
D
L
V
Y
T
A
F
S
G
S
H
Q
D
A
I
N
K
G
L
D
A
-
M
K
L
D
A
---
D
C
D
V
D
-
D
M
L
W
Q
V
P
Y
L
P
I
D
P
R
D
V
G
R
T
Y
E
A
V
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
58.80
26%
-80
- C2 -
4OV4
2
?
A:
[23-408]
---------------------------------------------------
P
K
T
I
H
I
Q
D
V
T
L
R
D
G
N
Q
A
L
K
R
P
W
T
I
-
D
E
K
I
E
V
F
-
D
L
L
-
V
E
L
-
N
V
D
G
I
E
V
G
F
P
S
S
N
E
T
------
E
F
H
T
C
Q
V
L
S
K
R
-----
A
P
K
G
K
P
I
A
A
L
S
R
A
N
Q
N
E
I
A
V
T
W
E
A
I
Q
K
A
D
C
P
R
M
H
I
V
Y
P
V
S
D
F
S
I
K
H
V
L
K
I
S
E
K
E
V
L
Q
K
I
R
N
S
I
S
F
A
R
S
I
V
G
--
P
G
--
I
E
I
Q
F
---
S
G
E
H
F
G
---
D
A
IE
N
F
A
F
T
K
E
A
F
L
T
A
I
E
A
-
G
-----
A
N
I
I
N
L
P
N
T
V
E
R
-
Y
R
P
M
V
F
V
N
M
V
K
E
-
I
K
D
V
V
K
--
D
K
A
I
I
S
I
H
T
H
N
D
L
G
M
A
T
A
T
S
V
E
S
V
Y
V
G
A
E
Q
I
E
V
A
L
N
G
L
G
E
------
R
A
G
N
T
N
L
Y
E
T
A
I
A
L
H
Q
----
N
---
G
---
E
N
L
N
I
N
F
Q
R
I
Y
P
T
A
K
R
I
S
E
L
T
G
I
P
I
G
E
K
T
P
I
I
G
E
D
I
F
S
H
R
S
G
I
H
Q
-------
H
------------------
Q
S
K
G
A
Y
R
T
F
S
P
E
F
V
G
R
M
D
K
E
T
I
S
F
T
-
N
Q
S
G
H
K
A
I
E
F
L
L
-
H
Q
-
R
G
I
Q
V
S
K
E
G
I
H
H
L
F
S
L
A
K
S
I
S
S
R
E
--
N
N
R
E
I
T
E
A
E
-
L
V
A
L
S
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------
55
Fugue
57.78
26%
-74
- C2 -
4OV4
2
?
A:
[23-408]
---------------------------------------------------
P
K
T
I
H
I
Q
D
V
T
L
R
D
G
N
Q
A
L
K
R
P
W
T
I
-
D
E
K
I
E
V
F
-
D
L
L
-
V
E
L
-
N
V
D
G
I
E
V
G
F
P
S
S
N
E
T
------
E
F
H
T
C
Q
V
L
S
K
R
A
-----
P
K
G
K
P
I
A
A
L
S
R
A
N
Q
N
E
I
A
V
T
W
E
A
I
Q
K
A
D
C
P
R
M
H
I
V
Y
P
V
S
D
F
S
I
K
H
V
L
K
I
S
E
K
E
V
L
Q
K
I
R
N
S
I
S
F
A
R
S
I
V
G
--
P
G
I
E
I
Q
F
S
G
---
E
H
F
G
D
A
---
I
E
--
N
F
A
F
T
K
E
A
F
L
T
A
I
E
A
G
A
N
------
I
I
N
L
P
N
T
V
E
R
-
Y
R
P
M
V
F
V
N
M
V
K
E
-
I
K
D
V
V
K
D
K
--
A
I
I
S
I
H
T
H
N
D
L
G
M
A
T
A
T
S
V
E
S
V
Y
V
G
A
E
Q
I
E
V
A
L
N
G
L
G
E
------
R
A
G
N
T
N
L
Y
E
T
A
I
A
L
H
Q
----
N
---
G
---
E
N
L
N
I
N
F
Q
R
I
Y
P
T
A
K
R
I
S
E
L
T
G
I
P
I
G
E
K
T
P
I
I
G
E
D
I
F
S
H
R
S
G
I
H
Q
H
Q
S
K
G
A
-------------------------
Y
R
T
F
S
P
E
F
V
G
R
M
D
K
E
T
I
S
F
T
-
N
Q
S
G
H
K
A
I
E
F
L
L
-
H
Q
R
-
G
I
Q
V
S
K
E
G
I
H
H
L
F
S
L
A
K
S
I
S
S
R
--
E
N
N
R
E
I
T
E
A
E
-
L
V
A
L
S
Q
----------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
54.90
25%
-76
- C2 -
3RMJ
4
LEU1_NEIMB
A:
[10-330]
---------------------------------------------------
T
N
R
V
I
I
F
D
T
T
L
R
D
G
E
Q
S
P
G
A
A
M
T
K
-
E
E
K
I
R
V
A
-
R
Q
L
-
E
K
L
-
G
V
D
I
I
E
A
G
F
A
A
A
S
P
G
------
D
F
E
A
V
N
A
I
A
K
T
-----
I
-
T
K
S
T
V
C
S
L
S
R
A
I
E
R
D
I
R
Q
A
G
E
A
V
A
P
A
P
K
K
R
I
H
T
F
I
A
T
S
P
I
H
M
E
Y
K
L
K
M
K
P
K
Q
V
I
E
A
A
V
K
A
V
K
I
A
R
E
Y
T
-------
D
D
V
E
F
---
S
C
E
D
A
L
---
R
S
--
E
I
D
F
L
A
E
I
C
G
A
V
I
E
A
-
G
-----
A
T
T
I
N
I
P
D
T
V
G
Y
-
S
I
P
Y
K
T
E
E
F
F
R
E
-
L
I
A
K
T
P
N
G
G
K
V
V
W
S
A
H
C
H
N
D
L
G
L
A
V
A
N
S
L
A
A
L
K
G
G
A
R
Q
V
E
C
T
V
N
G
L
G
E
------
R
A
G
N
A
S
V
E
E
I
V
M
A
L
K
V
R
HDL
F
---
G
---
L
E
T
G
I
D
T
T
Q
I
V
P
S
S
K
L
V
S
T
I
T
G
Y
P
V
Q
P
N
K
A
I
V
G
A
N
A
F
S
------------------------------------
E
T
Y
E
I
M
S
A
E
S
V
G
W
A
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
54.08
27%
-64
- C2 -
4OV9
2
?
A:
[31-367]
-----------------------------------------------------------
V
T
L
R
D
G
N
Q
A
L
K
R
P
W
T
I
-
D
E
K
I
E
V
F
-
D
L
L
-
V
E
L
-
N
V
D
G
I
E
V
G
F
P
S
S
N
E
T
------
E
F
H
T
C
Q
V
L
S
K
R
A
-----
P
K
G
K
P
I
A
A
L
S
R
A
N
Q
N
E
I
A
V
T
W
E
A
I
Q
K
A
D
C
P
R
M
H
I
V
Y
P
V
S
D
F
S
I
K
H
V
L
K
I
S
E
K
E
V
----
L
Q
K
I
R
N
S
I
S
F
A
R
S
I
V
G
P
G
I
E
I
Q
F
---
S
G
E
H
F
----
G
D
--
A
I
E
N
F
A
F
T
K
E
A
F
L
T
A
I
E
A
G
A
N
---
I
I
N
L
P
N
T
V
E
R
-
Y
R
P
M
V
F
V
N
M
V
K
E
-
I
K
D
V
V
--
K
D
K
A
I
I
S
I
H
T
H
N
D
L
G
M
A
T
A
T
S
V
E
S
V
Y
V
G
A
E
Q
I
E
V
A
L
N
G
L
G
E
------
R
A
G
N
T
N
L
Y
E
T
A
I
A
L
H
Q
----
N
---
G
---
E
N
L
N
I
N
F
Q
R
I
Y
P
T
A
K
R
I
S
E
L
T
G
I
P
I
G
E
K
T
P
I
I
G
E
D
I
F
S
H
R
S
G
I
H
Q
-----
T
L
H
Q
-
S
K
-----------------
G
A
Y
R
T
F
S
P
E
F
V
G
R
M
D
K
E
T
I
S
F
T
-
N
Q
S
G
H
K
A
I
E
F
L
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
53.35
27%
-64
- C2 -
4OV4
2
?
A:
[31-367]
-----------------------------------------------------------
V
T
L
R
D
G
N
Q
A
L
K
R
P
W
T
I
-
D
E
K
I
E
V
F
-
D
L
L
-
V
E
L
-
N
V
D
G
I
E
V
G
F
P
S
S
N
E
T
------
E
F
H
T
C
Q
V
L
S
K
R
A
-----
P
K
G
K
P
I
A
A
L
S
R
A
N
Q
N
E
I
A
V
T
W
E
A
I
Q
K
A
D
C
P
R
M
H
I
V
Y
P
V
S
D
F
S
I
K
H
V
L
K
I
S
E
K
E
V
----
L
Q
K
I
R
N
S
I
S
F
A
R
S
I
V
G
P
G
I
E
I
Q
F
---
S
G
E
H
F
----
G
D
--
A
I
E
N
F
A
F
T
K
E
A
F
L
T
A
I
E
A
G
A
N
---
I
I
N
L
P
N
T
V
E
R
-
Y
R
P
M
V
F
V
N
M
V
K
E
-
I
K
D
V
V
--
K
D
K
A
I
I
S
I
H
T
H
N
D
L
G
M
A
T
A
T
S
V
E
S
V
Y
V
G
A
E
Q
I
E
V
A
L
N
G
L
G
E
------
R
A
G
N
T
N
L
Y
E
T
A
I
A
L
H
Q
----
N
---
G
---
E
N
L
N
I
N
F
Q
R
I
Y
P
T
A
K
R
I
S
E
L
T
G
I
P
I
G
E
K
T
P
I
I
G
E
D
I
F
S
H
R
S
G
I
H
Q
-------
H
Q
-
S
K
-----------------
G
A
Y
R
T
F
S
P
E
F
V
G
R
M
D
K
E
T
I
S
F
T
-
N
Q
S
G
H
K
A
I
E
F
L
L
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
HHSearch
51.93
21%
-76
- C2 -
2ZTJ
2
HOSC_THET2
A:
[1-320]
---------------------------------------------------
M
R
E
W
K
I
I
D
S
T
L
R
E
G
E
Q
F
E
K
A
N
F
S
T
-
Q
D
K
V
E
I
A
-
K
A
L
-
D
E
F
-
G
I
E
Y
I
E
V
T
T
P
V
A
S
P
Q
------
S
R
K
D
A
E
V
L
A
S
L
G
------
L
K
A
K
V
V
T
H
I
Q
C
R
L
D
A
A
K
V
A
V
E
T
--
G
V
Q
--
G
I
D
L
L
F
G
T
---------
G
R
D
I
P
R
I
I
E
E
A
K
E
V
I
A
Y
I
R
E
A
A
P
H
-----
V
E
V
R
F
---
S
A
E
D
T
F
---
R
S
--
E
E
Q
D
L
L
A
V
Y
E
A
V
A
-
P
-
Y
-----
V
D
R
V
G
L
A
D
T
V
G
V
-
A
T
P
R
Q
V
Y
A
L
V
R
E
-
V
R
R
V
V
G
--
P
R
V
D
I
E
F
H
G
H
N
D
T
G
C
A
I
A
N
A
Y
E
A
I
E
A
G
A
T
H
V
D
T
T
I
L
G
I
G
E
------
R
N
G
I
T
P
L
G
G
F
L
A
R
M
Y
T
----
L
---
Q
P
E
Y
V
R
R
K
Y
K
L
E
M
L
P
E
L
D
R
M
V
A
R
M
V
G
V
E
I
P
F
N
N
Y
I
T
G
E
T
A
F
S
H
K
A
G
M
H
L
K
A
I
Y
I
N
----------------------
P
E
A
Y
E
P
Y
P
P
E
V
F
G
V
K
R
K
-
L
I
I
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
50.65
20%
-77
- C2 -
3IVS
2
HOSM_SCHPO
A:
[34-409]
------------------------------------------------
L
S
R
V
N
N
F
S
I
I
E
S
T
L
R
E
G
E
Q
F
A
N
A
F
F
D
T
-
E
K
K
I
Q
I
A
-
K
A
L
-
D
N
F
-
G
V
D
Y
I
E
L
T
S
P
V
A
S
E
Q
------
S
R
Q
D
C
E
A
I
C
K
L
G
------
L
K
C
K
I
L
T
H
I
R
C
H
M
D
D
A
R
V
A
V
E
T
--
G
V
D
--
G
V
D
V
V
I
G
T
-------------
T
Y
I
I
D
S
A
T
E
V
I
N
F
V
K
S
K
G
-------
I
E
V
R
F
---
S
S
E
D
S
F
---
R
S
--
D
L
V
D
L
L
S
L
Y
K
A
V
D
K
I
-
G
-----
V
N
R
V
G
I
A
D
T
V
G
C
-
A
T
P
R
Q
V
Y
D
L
I
R
T
-
L
R
G
V
V
----
S
C
D
I
E
C
H
F
H
N
D
T
G
M
A
I
A
N
A
Y
C
A
L
E
A
G
A
T
H
I
D
T
S
I
L
G
I
G
E
------
R
N
G
I
T
P
L
G
A
L
L
A
R
M
Y
V
----
T
D
R
E
Y
---
I
T
H
K
Y
K
L
N
Q
L
R
E
L
E
N
L
V
A
D
A
V
E
V
Q
I
P
F
N
N
Y
I
T
G
M
C
A
F
T
H
K
A
G
I
H
A
K
A
I
L
A
N
----------------------
P
S
T
Y
E
I
L
K
P
E
D
F
G
M
S
R
--
Y
V
H
V
G
S
R
L
T
G
W
N
A
I
K
S
R
A
-
E
Q
-
L
N
L
H
L
---
Q
A
K
E
L
T
V
R
I
K
K
L
A
-
V
-----
R
T
L
A
M
D
D
-
V
D
R
V
L
R
E
Y
H
A
------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
48.25
19%
-66
- C2 -
3BLE
2
?
A:
[19-337]
-----------------------------------------------------
R
L
E
I
L
D
V
T
L
R
D
G
E
Q
T
R
G
V
S
F
S
T
-
S
E
K
L
N
I
A
-
K
F
L
L
Q
K
L
-
N
V
D
R
V
E
I
A
S
A
R
V
S
K
G
------
E
L
E
T
V
Q
K
I
M
E
W
A
A
T
E
Q
L
T
E
R
I
E
I
L
G
F
V
D
G
N
-
K
T
V
D
W
I
K
D
S
--
G
A
K
--
V
L
N
L
L
T
K
G
S
L
H
H
L
E
K
Q
L
G
K
T
P
K
E
F
F
T
D
V
S
F
V
I
E
Y
A
I
K
S
G
-------
L
K
I
N
V
---
Y
L
E
D
W
S
N
G
F
R
N
--
S
P
D
Y
V
K
S
L
V
E
H
L
S
K
E
-
H
-----
I
E
R
I
F
L
P
D
T
L
G
V
-
L
S
P
E
E
T
F
Q
G
V
D
S
-
L
I
Q
K
Y
---
P
D
I
H
F
E
F
H
G
H
N
D
Y
D
L
S
V
A
N
S
L
Q
A
I
R
A
G
V
K
G
L
H
A
S
I
N
G
L
G
E
------
R
A
G
N
T
P
L
E
A
L
V
T
T
I
H
D
K---
S
---
N
---
S
K
T
N
I
N
E
I
A
I
T
E
A
S
R
L
V
E
V
F
S
G
K
R
I
S
A
N
R
P
I
V
G
E
D
V
F
T
Q
----------------------------------
N
L
Y
A
N
P
I
L
P
E
R
F
G
R
K
R
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
42
HHSearch
44.64
17%
-58
- C2 -
1YDN
1
?
A:
[2-284]
---------------------------------------------------
A
E
H
V
E
I
V
E
M
A
A
R
D
G
L
Q
N
E
K
R
F
V
P
T
-
A
D
K
I
A
L
I
-
N
R
L
-
S
D
C
-
G
Y
A
R
I
E
A
T
S
F
V
S
P
K
W
VPQLAD
S
R
E
V
M
A
G
I
R
R
A
-------
D
G
V
R
Y
S
V
L
V
P
N
-
M
K
G
Y
E
A
A
A
A
A
--
H
A
D
--
E
I
A
V
F
I
S
A
S
E
G
F
S
K
A
N
I
N
C
T
I
A
E
S
I
E
R
L
S
P
V
I
G
A
A
I
N
D
G
L
A
I
R
G
---
Y
V
S
C
VVE
C
P
Y
D
G
P
----
V
--
T
P
Q
A
V
A
S
V
T
E
Q
L
F
S
L
-
G
-----
C
H
E
V
S
L
G
D
T
I
G
R
-
G
T
P
D
T
V
A
A
M
L
D
A
-
V
L
A
I
A
---
P
A
H
S
L
A
G
H
Y
H
D
T
G
G
R
A
L
D
N
I
R
V
S
L
E
K
G
L
R
V
F
D
A
S
V
G
G
L
G
G
CPFAPG
A
K
G
N
V
D
T
V
A
V
V
E
M
L
H
E
----
M
---
G
---
F
E
T
G
L
D
L
D
R
L
R
S
A
G
L
F
T
Q
A
L
R
Q
D
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------