@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3800c: (2016-05-23 )
MADVAESQENAPAERAELTVPEMRQWLRNWVGKAVGKAPDSIDESVPMVELGLSSRDAVAMAADIEDLTGVTLSVAVAFAHPTIESLATRIIEGEPETDLAGDDAEDWSRTGPAERVDIAIVGLSTRFPGEMNTPEQTWQALLEGRDGITDLPDGRWSEFLEEPRLAARVAGARTRGGYLKDIKGFDSEFFAVAKTEADNIDPQQRMALELTWEALEHARIPASSLRGQAVGVYIGSSTNDYSFLAVSDPTVAHPYAITGTSSSIIANRVSYFYDFHGPSVTIDTACSSSLVAIHQGVQALRNGEADVVVAGGVNALITPMVTLGFDEIGAVLAPDGRIKSFSADADGYTRSEGGGMLVLKRVDDARRDGDAILAVIAGSAVNHDGRSNGLIAPNQDAQADVLRRAYKDAGIDPRTVDYIEAHGTGTILGDPIEAEALGRVVGRGRPADRPALLGAVKTNVGHLESAAGAASMAKVVLALQHDKLPPSINFAGPSPYIDFDAMRLKMITTPTDWPRYGGYALAGVSSFGFGGANAHVVVREVLPRDVVEKEPEPEPEPKAAAEPAEAPTLAGHALRFDEFGNIITDSAVAEEPEPELPGVTEEALRLKEAALEELAAQEVTAPLVPLAVSAFLTSRKKAAAAELADWMQSPEGQASSLESIGRSLSRRNHGRSRAVVLAHDHDEAIKGLRAVAAGKQAPNVFSVDGPVTTGPVWVLAGFGAQHRKMGKSLYLRNEVFAAWIEKVDALVQDELGYSVLELILDDAQDYGIETTQVTIFAIQIALGELLRHHGAKPAAVIGQSLGEAASAYFAGGLSLRDATRAICSRSHLMGEGEAMLFGEYIRLMALVEYSADEIREVFSDFPDLEVCVYAAPTQTVIGGPPEQVDAILARAEAEGKFARKFATKGASHTSQMDPLLGELTAELQGIKPTSPTCGIFSTVHEGRYIKPGGEPIHDVEYWKKGLRHSVYFTHGIRNAVDSGHTTFLELAPNPVALMQVALTTADAGLHDAQLIPTLARKQDEVSSMVSTMAQLYVYGHDLDIRTLFSRASGPQDYANIPPTRFKRKEHWLPAHFSGDGSTYMPGTHVALPDGRHVWEYAPRDGNVDLAALVRAAAAHVLPDAQLTAAEQRAVPGDGARLVTTMTRHPGGASVQVHARIDESFTLVYDALVSRAGSESVLPTAVGAATAIAVADGAPVAPETPAEDADAETLSDSLTTRYMPSGMTRWSPDSGETIAERLGLIVGSAMGYEPEDLPWEVPLIELGLDSLMAVRIKNRVEYDFDLPPIQLTAVRDANLYNVEKLIEYAVEHRDEVQQLHEHQKTQTAEEIARAQAELLHGKVGKTEPVDSEAGVALPSPQNGEQPNPTGPALNVDVPPRDAAERVTFATWAIVTGKSPGGIFNELPRLDDEAAAKIAQRLSERAEGPITAEDVLTSSNIEALADKVRTYLEAGQIDGFVRTLRARPEAGGKVPVFVFHPAGGSTVVYEPLLGRLPADTPMYGFERVEGSIEERAQQYVPKLIEMQGDGPYVLVGWSLGGVLAYACAIGLRRLGKDVRFVGLIDAVRAGEEIPQTKEEIRKRWDRYAAFAEKTFNVTIPAIPYEQLEELDDEGQVRFVLDAVSQSGVQIPAGIIEHQRTSYLDNRAIDTAQIQPYDGHVTLYMADRYHDDAIMFEPRYAVRQPDGGWGEYVSDLEVVPIGGEHIQAIDEPIIAKVGEHMSRALGQIEADRTSEVGKQ
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.....--..160.-.......170.......180.......190.......200.......210.......220....-------...230.......240.......250--.-........-260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380....-.-.-.390.......400.......410.......420.......430.......440.....-------..450.......460.......470.......480.......490.......-500.......510...-..------..520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640......-----.650--.-----......660...-.-...670........680.......690.......700.......710--.......720.......730.......740.......750.......760-..--.--....---.770.......780.......790.......800.......810.......820.......830--.........840.......850.......860-.-..-.....870.......880.......890.......900..-.-.-...910.......920.....--..--930.......940.......950.......960.......970.......980.......990.......1000.-.--....1010.....-.1020......1030......1040......---1050...---...1060......1070.------.....1080......1090......1100...-...1110......1120......1130......1140-......1150......1160......1170......1180......1190......1200......1210......1220......1230......1240......1250......1260......1270---.......1280......1290......----1300......1310.-----.....1320......1330......1340......1350......1360......1370......1380......1390......1400--.......1410......1420......1430......1440......1450......1460----......1470......1480......1490......1500......1510......1520......1530........1540......1550......1560......1570......1580......1590.....-.1600......1610......1620......1630......1640......1650......1660......1670......1680------.......1690......1700......1710......1720......1730--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAD
V
A
ESQENAPAERAEL
T
V
P
E
M
R
Q
W
L
R
N
W
V
G
K
A
VGKAPDSIDESV
P
M
V
E
LGLSSRD
A
V
A
M
AA
D
I
E
D
LTG
V
T
L
S
V
A
V
A
FAHP
T
I
E
S
L
A
T
R
I
IEGEPETDLAGD
D
A
E
D
WSRTGPA
E
R
V
D
I
A
I
V
G
LSTRFPGEMN
T
P
E
Q
T
W
Q
A
L
LEGRDGITDLPD
G
R
W
--
S
E
F
L
-E-E
P
R
L
A
A
R
VAGARTRGGY
L
K
D
IKGFDSE
F
F
A
V
AKTEADNI
D
P
Q
Q
R
M
A
L
E
L
T
W
E
A
L
E
HARI
P
A
S
SL-------RG
Q
A
V
G
V
Y
IGSSTN
D
Y
S
F
L
A
VSDP----T-VAH
P
Y
A
IT-GT
S
S
S
I
I
A
N
R
V
S
Y
F
Y
DFHGP
S
V
T
I
DTACS
S
S
L
V
A
I
H
Q
G
V
Q
A
L
RNGEA
D
V
V
V
AGG
V
N
A
L
I
T
P
M
V
TL
G
F
D
E
I
G
A
V
LAPDG
R
I
K
S
FSADADGYTRSEGG
G
M
L
V
L
KRVDDARRDG
D
A
I
L
A
V
I
AGSAVNHDG-R-S-NGLIAPNQ
D
A
Q
A
D
V
L
R
R
A
Y
K
DAGIDPR
T
V
D
Y
I
EAHGTGTILGDP
I
E
A
E
A
L
G
R
V
VGRGRP-------ADR
P
A
L
L
G
A
V
KTNVGH
L
E
S
AA
G
A
A
S
M
A
K
V
V
L
A
L
QHDKLPPSINFAGPSPYID-FD
A
M
R
L
K
M
ITTPTDWP-RY------G
G
Y
A
L
AGVSSFGFGGA
N
A
H
V
V
V
R
E
VL
P
R
D
V
VEKEPEPEPEPKAAAEPAEAPTLAG
H
A
L
R
F
D
E
FGNIITDSAVAEEPEPELPGV
T
E
E
A
L
R
L
K
E
A
A
L
E
E
L
A
A
Q
E
VTA
P
L
V
P
L
A
V
S
A
F
L
T
SR
K
K
A
A
A
A
E
L
A
D
W
M
-----QSPE--G-----
Q
A
S
S
L
E
S
I
G
R
S
L
-
S
-RRNHG-R
S
R
A
V
V
L
AHD
H
D
E
A
I
K
G
L
R
A
V
AAGKQAP
N
V
F
SVDGPVTTG
P
--
V
W
V
L
AGF
G
A
Q
H
R
K
MG
K
S
L
Y
L
R
N
E
V
F
A
A
W
I
E
K
V
D
A
L
V
Q
D
EL
G
Y
S
V
L
E
L
I
L--D
D
--
A
--
Q
DYG---I
E
T
T
Q
V
T
I
F
A
I
Q
I
A
L
G
E
L
L
R
HHGAK
P
A
A
V
I
G
Q
S
L
G
E
A
A
S
A
Y
FAGGL
S
L
R
D
A
T
R
A
I
C
S
RSHLM----GEG
E
A
M
L
F
G
E
Y
I
R
L
M
A
L
V
EY
S
A
D
E
I
R
E
V
F
S
D--F-PD-
L
E
V
C
V
YAAPTQTVIGG
P
P
E
Q
V
D
A
I
L
A
R
AEAE
G
K
F
A
R
K
F
A
T-K-G-ASHT
S
Q
M
D
P
L
L
G
E
L
T
A
E
LQGI--KP--TSPT
C
G
I
F
S
T
VHEG
R
Y
IKPGGEPIH
D
V
E
Y
W
K
KGLRH
S
V
Y
F
THGIRNAVDSG
H
T
T
F
L
E
LAPN
P
V
A
L
M
Q
V
A
LTTADA-G--LH
D
A
Q
L
I
P
T
L
A
R
K
-
Q
D
E
V
S
S
M
V
S
T
M
A
Q
L
Y
VYGHD
L
D
I
R
T
L
F
SRAS---GPQDYAN---IP
P
T
RFKRKEHWLPAHFS------GDGSTYMPG
T
H
VALPDG
R
H
V
W
E
YAPRDGNV
D
L
-
A
A
L
V
R
A
A
A
A
HVLPD
A
Q
LT
A
A
E
QRAVPGDG
A
R
L
V
T
T
MT-RHPGG
A
S
V
Q
V
H
A
RIDE
S
F
T
L
V
Y
D
A
L
V
SRAGSESVLPTAVG
A
A
T
A
I
A
VADGAPVAPETPAEDA
D
A
E
T
L
S
D
S
L
T
T
RYMPSGMTRWSPDS
G
E
T
I
A
E
R
L
G
L
I
V
GSAMGYEPEDLPWEV
P
L
I
E
L
G
L
D
S
L
M
A
V
R
I
----KN
R
V
E
Y
DFDLP
P
I
Q
L
T
A
VRDANLY
N
V
E
----
K
L
I
E
Y
A
V
E
H
R
D
E
V
Q
Q
-----
L
H
E
H
QKT
Q
T
A
E
E
I
A
R
A
Q
A
E
L
L
HGKVGKTEPVDSEAGVALPSPQNGEQPNPTGP
A
L
NVDVPPR
D
A
AE
R
V
T
F
A
T
W
A
I
V
TGKSPG
G
I
F
N
EL---PRL
D
D
E
A
A
A
K
I
A
Q
R
L
S
E
RAEGPI
T
A
E
D
VLTSS
N
I
E
A
L
A
D
K
V
R
T
Y
L
E
A
GQ
I
D
G
F
V
R
T
L
R
ARP----EAGGK
V
P
V
F
V
F
HPAGG
S
T
V
V
Y
E
P
L
LGRLPADTPMY
G
F
E
R
VE
G
S
I
E
E
R
A
Q
Q
Y
V
P
K
L
I
EMQGDG
P
Y
V
L
V
--GWS
L
G
G
V
L
A
Y
A
C
A
I
G
L
R
R
LGKD
V
R
F
V
G
L
I
D
A
V
RAGEEIP
Q
T
K
E
E
I
R
K
R
W
D
R
Y
A
A
F
A
E
K
T
F
N
V
T
IPAI
P
-
Y
E
Q
L
E
ELDDEG
Q
V
R
F
V
L
D
A
V
S
QSGVQI
P
A
G
I
I
E
H
Q
R
T
S
YLDNRAIDT
A
Q
IQPYD
G
H
V
T
L
Y
M
ADRYHDD
A
I
M
FEPRYAVRQPDGG-------
W
G
E
YVSD
L
E
V
VPIG
G
E
H
I
Q
A
I
D
E
P
I
I
A
K
V
G
E
H
M
S
R
A
L
G
Q
IEAD
R
T
S
EVGKQ--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
82.53
37%
-67
- C2 -
2HG4
2
ERYA3_SACER
A:
[37-901]
------------------------------------------------------------------------------------------------------------------
A
G
E
P
I
A
I
V
G
M
A
C
R
F
P
G
D
V
D
S
P
E
S
F
W
E
F
V
S
G
G
G
D
A
I
A
E
A
P
A
D
R
G
--
W
E
P
D
------------
P
D
A
R
L
G
G
M
L
A
A
A
G
D
F
D
A
G
F
F
G
I
S
P
R
E
A
L
A
M
D
P
Q
Q
R
I
M
L
E
I
S
W
E
A
L
E
R
A
G
H
D
P
V
S
L
-------
R
G
S
A
T
G
V
F
T
G
V
G
T
V
D
Y
G
P
R
P
D
E
A
P
----
D
-
E
V
L
G
Y
V
G
T
-
G
T
A
S
S
V
A
S
G
R
V
A
Y
C
L
G
L
E
G
P
A
M
T
V
D
T
A
C
S
S
G
L
T
A
L
H
L
A
M
E
S
L
R
R
D
E
C
G
L
A
L
A
G
G
V
T
V
M
S
S
P
G
A
F
T
E
F
R
S
Q
-
G
G
L
A
A
D
G
R
C
K
P
F
S
K
A
A
D
G
F
G
L
A
E
G
A
G
V
L
V
L
Q
R
L
S
A
A
R
R
E
G
R
P
V
L
A
V
L
R
G
S
A
V
N
Q
D
G
-
A
-
S
-
N
G
L
T
A
P
S
G
P
A
Q
Q
R
V
I
R
R
A
L
E
N
A
G
V
R
A
G
D
V
D
Y
V
E
A
H
G
T
G
T
R
L
G
D
P
I
E
V
H
A
L
L
S
T
Y
G
A
E
R
D
-------
P
D
D
P
L
W
I
G
S
V
K
S
N
I
G
H
T
Q
A
A
A
G
V
A
G
V
M
K
A
V
L
A
L
R
H
G
E
M
P
R
T
L
H
F
D
E
P
S
P
Q
I
E
-
W
---
A
V
S
V
V
S
Q
A
R
S
W
P
-
A
G
------
E
R
P
R
R
A
G
V
S
S
F
G
I
S
G
T
N
A
H
V
I
V
E
E
A
P
E
A
D
----------------------------------------------------------------------------
G
P
V
P
L
V
L
S
G
R
D
E
Q
A
M
R
A
Q
A
G
R
L
A
D
H
L
-----
A
R
E
---------
P
R
N
S
L
R
D
T
G
F
T
L
-
A
T
R
R
S
A
W
-
E
H
R
A
V
V
V
-
G
D
R
D
E
A
L
A
G
L
R
A
V
A
D
G
R
I
A
D
R
T
A
T
G
Q
A
R
T
R
R
G
V
--
A
M
V
F
P
G
Q
G
A
Q
W
Q
G
M
A
R
D
L
L
R
E
S
Q
V
F
A
D
S
I
R
D
C
E
R
A
L
A
P
H
V
D
W
S
L
T
D
L
L
S
--
G
A
--
R
--
P
L
D
R
---
V
D
V
V
Q
P
A
L
F
A
V
M
V
S
L
A
A
L
W
R
S
H
G
V
E
P
A
A
V
V
G
H
S
Q
G
E
I
A
A
A
H
V
A
G
A
L
T
L
E
D
A
A
K
L
V
A
V
R
S
R
V
L
----
R
R
L
G
------
G
Q
G
G
M
A
S
F
G
L
G
T
E
Q
A
A
E
R
I
G
R
--
F
A
G
A
-
L
S
I
A
S
V
N
G
P
R
S
V
V
V
A
G
E
S
G
P
L
D
E
L
I
A
E
C
E
A
E
A
H
K
A
R
R
I
P
V
-
D
-
Y
-
A
S
H
S
P
Q
V
E
S
L
R
E
E
L
L
T
E
L
A
G
I
--
S
P
--
V
S
A
D
V
A
L
Y
S
T
T
T
G
Q
P
I
D
T
----
A
T
M
D
T
A
Y
W
Y
A
N
L
R
E
Q
V
R
F
Q
D
A
T
R
Q
L
A
E
A
G
F
D
A
F
V
E
V
S
P
H
P
V
L
T
V
G
I
E
A
T
L
D
S
A
-
L
PA
D
A
G
A
C
V
V
G
T
L
R
R
D
-
R
G
G
L
A
D
F
H
T
A
L
G
E
A
Y
A
Q
G
V
E
V
D
W
S
P
A
F
A
D
-------
A
R
P
V
E
---
L
P
V
Y
P
F
Q
R
Q
R
Y
W
L
P
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
64
Fugue
81.75
37%
-63
- C2 -
2QO3
3
ERYA2_SACER
A:
[4-883]
------------------------------------------------------------------------------------------------------------------
E
S
D
P
I
A
I
V
S
M
A
C
R
L
P
G
G
V
N
T
P
Q
R
L
W
E
L
L
R
E
G
G
E
T
L
S
G
F
P
T
D
R
G
WD
L
A
R
L
-
H
-
H
P
D
P
D
N
P
G
T
S
Y
V
D
K
G
G
F
L
D
D
A
A
G
F
D
A
E
F
F
G
V
S
P
R
E
A
A
A
M
D
P
Q
Q
R
L
L
L
E
T
S
W
E
L
V
E
N
A
G
I
D
P
H
S
L
-------
R
G
T
A
T
G
V
F
L
G
V
A
K
F
G
Y
G
----
E
D
T
----
A
-
D
V
E
G
Y
S
V
T
-
G
V
A
P
A
V
A
S
G
R
I
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Y
T
M
G
L
E
G
P
S
I
S
V
D
T
A
C
S
S
S
L
V
A
L
H
L
A
V
E
S
L
R
K
G
E
S
S
M
A
V
V
G
G
A
A
V
M
A
T
P
G
V
F
V
D
F
S
R
Q
R
A
-
L
A
A
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G
R
S
K
A
F
G
A
G
A
D
G
F
G
F
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E
G
V
T
L
V
L
L
E
R
L
S
E
A
R
R
N
G
H
E
V
L
A
V
V
R
G
S
A
L
N
Q
D
G
-
A
-
S
-
N
G
L
S
A
P
S
G
P
A
Q
R
R
V
I
R
Q
A
L
E
S
C
G
L
E
P
G
D
V
D
A
V
E
A
H
G
T
G
T
A
L
G
D
P
I
E
A
N
A
L
L
D
T
Y
G
R
D
R
D
-------
A
D
R
P
L
W
L
G
S
V
K
S
N
I
G
H
T
Q
A
A
A
G
V
T
G
L
L
K
V
V
L
A
L
R
N
G
E
L
P
A
T
L
H
V
E
E
P
T
P
H
V
D
-
W
S
S
G
G
V
A
L
L
A
G
N
Q
P
W
R
-
R
G
------
E
R
T
R
R
A
A
V
S
A
F
G
I
S
G
T
N
A
H
V
I
V
E
E
---------
A
P
E
H
D
G
R
P
------------------------------------------------------------------
V
P
L
V
V
S
A
---
R
S
T
A
A
L
R
A
Q
A
A
Q
I
A
-----
E
L
L
E
--
R
-----
P
D
A
D
L
A
G
V
G
L
G
L
-
A
T
T
R
A
R
H
-
E
H
R
A
A
V
V
A
S
T
R
E
E
A
V
R
G
L
R
E
I
A
A
G
A
A
T
A
D
A
V
V
E
G
V
T
E
V
D
G
R
N
V
V
F
L
F
P
G
Q
G
S
Q
W
A
G
M
G
A
E
L
L
S
S
S
P
V
F
A
G
K
I
R
A
C
D
E
S
M
A
P
M
Q
D
W
K
V
S
D
V
L
R
--
Q
A
--
P
--
G
A
P
G
LDR
V
D
V
V
Q
P
V
L
F
A
V
M
V
S
L
A
E
L
W
R
S
Y
G
V
E
P
A
A
V
V
G
H
S
Q
G
E
I
A
A
A
H
V
A
G
A
L
T
L
E
D
A
A
K
L
V
V
G
R
S
R
L
M
----
R
S
L
S
G
E
------
G
G
M
A
A
V
A
L
G
E
A
A
V
R
E
R
L
R
P
--
W
-
Q
D
R
L
S
V
A
A
V
N
G
P
R
S
V
V
V
S
G
E
P
G
A
L
R
A
F
S
E
D
C
A
A
E
G
I
R
V
R
D
I
D
V
-
D
-
Y
-
A
S
H
S
P
Q
I
E
R
V
R
E
E
L
L
E
T
T
G
D
I
--
A
P
--
R
P
A
R
V
T
F
H
S
T
V
E
S
R
S
M
----
D
G
T
E
L
D
A
R
Y
W
Y
R
N
L
R
E
T
V
R
F
A
D
A
V
T
R
L
A
E
S
G
Y
D
A
F
I
E
V
S
P
H
P
V
V
V
Q
A
V
E
E
A
V
E
E
A
D
G
--
A
E
D
A
V
V
V
G
S
L
H
R
D
-
G
G
D
L
S
A
F
L
R
S
M
A
T
A
H
V
S
G
V
D
I
R
W
D
V
A
L
P
G
A
A
---
P
F
----
A
---
L
P
T
Y
P
F
Q
R
K
R
Y
W
L
Q
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
38
HHSearch
81.35
37%
-69
- C2 -
5BP1
-
?
A:
[6-887]
-------------------------------------------------------------------------------------------------------------------
V
A
P
V
A
I
I
G
M
A
C
R
L
P
G
A
I
N
S
P
Q
Q
L
W
E
A
L
L
R
G
D
D
F
V
T
E
I
P
T
G
R
----------------------
K
W
G
A
F
L
D
D
P
A
A
F
D
P
E
F
F
G
I
T
E
R
E
A
A
A
I
D
P
Q
H
R
L
L
L
E
T
A
W
E
A
V
E
H
S
G
L
N
P
A
G
L
-------
A
G
S
A
T
G
V
F
M
G
L
T
H
N
--------------------------
T
S
F
S
L
A
S
G
R
I
A
Y
A
L
G
V
H
G
P
A
I
T
V
D
T
A
C
S
S
S
L
S
A
I
H
M
A
C
R
S
L
H
D
G
E
S
D
V
A
L
A
G
G
V
S
V
L
L
E
-----------
G
M
L
S
P
T
G
H
C
H
A
F
D
T
A
A
D
G
F
V
S
A
E
G
C
V
V
L
T
L
K
R
L
D
D
A
V
A
D
G
D
R
I
L
A
V
I
R
G
T
A
T
N
Q
D
G
-----------
S
A
D
A
Q
A
K
V
Y
R
M
A
L
K
A
A
G
V
E
P
G
T
V
G
L
V
E
A
H
G
T
G
T
P
V
G
D
P
L
E
F
S
S
L
A
E
V
Y
G
T
D
-----------
G
P
C
A
L
G
S
I
K
T
N
F
G
H
T
Q
S
A
A
G
A
L
G
V
M
K
A
V
L
A
L
Q
H
N
V
I
P
Q
N
L
H
F
T
R
L
P
D
Q
M
A
-
E
I
E
T
G
L
F
V
P
E
T
I
T
P
W
P
-
V
R
E-----
G
Q
P
R
R
A
A
V
S
A
Y
G
L
S
G
T
N
V
H
A
V
L
E
Q
A
P
E
S
-------------------------------------------------------------------------
P
K
A
G
N
A
L
V
F
P
V
S
A
S
S
A
D
A
L
R
S
T
A
Q
H
L
A
D
W
L
-----
L
R
S
G
--
D
GNGRG
P
A
I
D
L
G
D
L
A
Y
T
L
-
A
R
R
R
G
F
R
-
A
A
R
S
A
V
L
A
G
D
R
G
T
L
V
E
G
L
R
Q
I
A
D
G
E
A
M
P
Q
Q
--
A
V
T
N
D
D
R
G
P
--
V
W
V
F
S
G
Q
G
S
Q
W
A
S
M
G
A
E
L
L
D
R
E
P
A
F
A
A
A
I
A
E
L
E
P
L
I
A
A
E
S
D
F
S
V
T
E
A
L
T
--
A
S
--
E
--
T
V
T
G
---
I
D
R
V
Q
P
T
I
F
A
V
Q
V
A
L
A
A
A
M
R
S
H
G
V
V
P
G
A
V
I
G
H
S
M
G
E
V
A
A
S
V
V
S
G
A
L
S
L
E
D
G
V
K
V
I
C
R
R
T
R
L
M
----
T
R
I
A
------
G
S
G
A
M
A
M
V
E
L
P
A
Q
Q
V
L
S
E
L
A
S
R
G
V
-
D
D
-
V
V
L
S
V
V
A
S
P
Q
S
T
V
V
G
G
A
T
A
S
V
R
E
L
I
E
M
W
E
S
R
G
V
M
A
R
E
I
A
V
-
D
-
V
-
A
S
H
S
P
Q
V
D
P
I
L
D
D
L
I
E
A
L
A
D
L
--
D
P
--
A
E
P
E
I
P
Y
Y
S
A
T
L
Y
D
P
R
D
----
Y
A
D
Y
D
A
Y
Y
W
A
D
N
L
R
H
T
V
R
F
S
A
A
V
Q
A
A
L
E
D
G
H
R
V
F
A
E
L
S
P
H
P
L
L
T
H
P
V
E
Q
T
A
R
S
L
-
D
--
M
-
P
L
A
V
F
A
A
M
R
R
Q
-
Q
E
M
P
H
G
L
L
G
F
V
A
D
L
H
S
A
G
A
A
V
D
F
S
V
L
Y
P
T
-------
G
R
L
L
D
---
A
P
L
P
A
W
T
H
S
T
L
L
L
D
R
E
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
PsiBlast_PDB
81.34
36%
-75
- C2 -
5BP1
-
?
A:
[9-864]
----------------------------------------------------------------------------------------------------------------------
V
A
I
I
G
M
A
C
R
L
P
G
A
I
N
S
P
Q
Q
L
W
E
A
L
L
R
G
D
D
F
V
T
E
I
P
T
G
R
----------------------
K
W
G
A
F
L
D
D
P
A
A
F
D
P
E
F
F
G
I
T
E
R
E
A
A
A
I
D
P
Q
H
R
L
L
L
E
T
A
W
E
A
V
E
H
S
G
L
N
P
A
G
L
-------
A
G
S
A
T
G
V
F
M
G
L
T
H
N
--------------------------
T
S
F
S
L
A
S
G
R
I
A
Y
A
L
G
V
H
G
P
A
I
T
V
D
T
A
C
S
S
S
L
S
A
I
H
M
A
C
R
S
L
H
D
G
E
S
D
V
A
L
A
G
G
V
S
V
L
L
E
----------
G
-
M
L
S
P
T
G
H
C
H
A
F
D
T
A
A
D
G
F
V
S
A
E
G
C
V
V
L
T
L
K
R
L
D
D
A
V
A
D
G
D
R
I
L
A
V
I
R
G
T
A
T
N
Q
D
G
-----------
S
A
D
A
Q
A
K
V
Y
R
M
A
L
K
A
A
G
V
E
P
G
T
V
G
L
V
E
A
H
G
T
G
T
P
V
G
D
P
L
E
F
S
S
L
A
E
V
Y
G
-----------
T
D
G
P
C
A
L
G
S
I
K
T
N
F
G
H
T
Q
S
A
A
G
A
L
G
V
M
K
A
V
L
A
L
Q
H
N
V
I
P
Q
N
L
H
F
T
R
L
P
D
Q
M
A
-
E
I
E
T
G
L
F
V
P
E
T
I
T
P
W
P
V
R
E
------
G
Q
P
R
R
A
A
V
S
A
Y
G
L
S
G
T
N
V
H
A
---------
V
L
E
Q
A
P
E
---
S
----------
P
K
-
A
G
N
A
L
V
F
--------------------------------------------------
P
V
S
A
S
S
A
D
A
L
R
S
T
A
Q
H
L
A
D
W
L
L
R
S
GD
G
N
G
R
--
G
-----
P
A
I
D
L
G
D
L
A
Y
T
L
A
R
-
R
R
G
F
R
-
A
A
R
S
A
V
L
A
G
D
R
G
T
L
V
E
G
L
R
Q
I
A
D
G
E
A
M
P
Q
Q
A
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T
N
D
--
D
R
G
P
--
V
W
V
F
S
G
Q
G
S
Q
W
A
S
M
G
A
E
L
L
D
R
E
P
A
F
A
A
A
I
A
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L
E
P
L
I
A
A
E
S
D
F
S
V
T
E
A
L
T
--
A
S
--
E
--
T
V
T
G
---
I
D
R
V
Q
P
T
I
F
A
V
Q
V
A
L
A
A
A
M
R
S
H
G
V
V
P
G
A
V
I
G
H
S
M
G
E
V
A
A
S
V
V
S
G
A
L
S
L
E
D
G
V
K
V
I
C
R
R
T
R
L
M
T
R
I
A
G
S
G
A
----------
M
A
M
V
E
L
P
A
Q
Q
V
L
S
E
L
A
S
R
G
V
-
D
D
-
V
V
L
S
V
V
A
S
P
Q
S
T
V
V
G
G
A
T
A
S
V
R
E
L
I
E
M
W
E
S
R
G
V
M
A
R
E
I
A
V
-
D
-
V
-
A
S
H
S
P
Q
V
D
P
I
L
D
D
L
I
E
A
L
A
D
L
--
D
P
--
A
E
P
E
I
P
Y
Y
S
A
T
----
L
Y
D
P
R
D
Y
A
D
Y
D
A
Y
Y
W
A
D
N
L
R
H
T
V
R
F
S
A
A
V
Q
A
A
L
E
D
G
H
R
V
F
A
E
L
S
P
H
P
L
L
T
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P
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T
A
R
S
L
-
D
--
M
P
L
A
-
V
F
A
A
M
R
R
Q
-
Q
E
M
P
H
G
L
L
G
F
V
A
D
L
H
S
A
G
A
A
V
D
F
S
V
L
Y
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
77.96
99%
-88
- C2 -
3TZY
7
?
A:
[25-488]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
G
V
T
E
E
A
L
R
L
K
E
A
A
L
E
E
L
A
A
Q
E
V
T
A
P
L
V
P
L
A
V
S
A
F
L
T
S
R
K
K
A
A
A
A
E
L
A
D
W
M
-----
Q
S
P
E
--
G
-----
Q
A
S
S
L
E
S
I
G
R
S
L
-
S
-
R
R
N
H
G
-
R
S
R
A
V
V
L
A
H
D
H
D
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A
A
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A
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N
V
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V
D
G
P
V
T
T
G
P
--
V
W
V
L
A
G
F
G
A
Q
H
R
K
M
G
K
S
L
Y
L
R
N
E
V
F
A
A
W
I
E
K
V
D
A
L
V
Q
D
E
L
G
Y
S
V
L
E
L
I
L
--
D
D
--
A
--
Q
D
Y
G
---
I
E
T
T
Q
V
T
I
F
A
I
Q
I
A
L
G
E
L
L
R
H
H
G
A
K
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A
A
V
I
G
Q
S
L
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A
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F
A
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G
L
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L
R
D
A
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R
A
I
C
S
R
S
H
L
M
----
G
E
G
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A
M
L
F
G
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Y
I
R
L
M
A
L
V
E
Y
S
A
D
E
I
R
E
V
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D
--
F
-
P
D
-
L
E
V
C
V
Y
A
A
P
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Q
T
V
I
G
G
P
P
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Q
V
D
A
I
L
A
R
A
E
A
E
G
K
F
A
R
K
F
A
T
-
K
-
G
-
A
S
H
T
S
Q
M
D
P
L
L
G
E
L
T
A
E
L
Q
G
I
--
K
P
--
T
S
P
T
C
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F
S
T
V
H
E
G
R
Y
I
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G
G
E
P
I
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V
E
Y
W
K
K
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L
R
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Y
F
T
H
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A
V
D
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H
T
T
F
L
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A
P
N
P
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A
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M
Q
V
A
L
T
T
A
D
A
-
G
--
L
H
D
A
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L
I
P
T
L
A
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K
-
Q
D
E
V
S
S
M
V
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M
A
Q
L
Y
V
Y
G
H
D
L
D
I
R
T
L
F
S
R
A
S
---
G
P
Q
D
Y
A
N
---
I
P
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
PsiBlast_CBE
77.88
99%
-87
- C2 -
3TZY
7
?
B:
[26-491]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
G
V
T
E
E
A
L
R
L
K
E
A
A
L
E
E
L
A
A
Q
E
V
T
A
P
L
V
P
L
A
V
S
A
F
L
T
S
R
K
K
A
A
A
A
E
L
A
D
W
M
-----
Q
S
P
E
--
G
-----
Q
A
S
S
L
E
S
I
G
R
S
L
-
S
-
R
R
N
H
G
-
R
S
R
A
V
V
L
A
H
D
H
D
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A
I
K
G
L
R
A
V
A
A
G
K
Q
A
P
N
V
F
S
V
D
G
P
V
T
T
G
P
--
V
W
V
L
A
G
F
G
A
Q
H
R
K
M
G
K
S
L
Y
L
R
N
E
V
F
A
A
W
I
E
K
V
D
A
L
V
Q
D
E
L
G
Y
S
V
L
E
L
I
L
--
D
D
--
A
--
Q
D
Y
G
---
I
E
T
T
Q
V
T
I
F
A
I
Q
I
A
L
G
E
L
L
R
H
H
G
A
K
P
A
A
V
I
G
Q
S
L
G
E
A
A
S
A
Y
F
A
G
G
L
S
L
R
D
A
T
R
A
I
C
S
R
S
H
L
M
----
G
E
G
E
A
M
L
F
G
E
Y
I
R
L
M
A
L
V
E
Y
S
A
D
E
I
R
E
V
F
S
D
--
F
-
P
D
-
L
E
V
C
V
Y
A
A
P
T
Q
T
V
I
G
G
P
P
E
Q
V
D
A
I
L
A
R
A
E
A
E
G
K
F
A
R
K
F
A
T
-
K
-
G
-
A
S
H
T
S
Q
M
D
P
L
L
G
E
L
T
A
E
L
Q
G
I
--
K
P
--
T
S
P
T
C
G
I
F
S
T
V
H
E
G
R
Y
I
K
P
G
G
E
P
I
H
D
V
E
Y
W
K
K
G
L
R
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S
V
Y
F
T
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G
I
R
N
A
V
D
S
G
H
T
T
F
L
E
L
A
P
N
P
V
A
L
M
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V
A
L
T
T
A
D
A
-
G
--
L
H
D
A
Q
L
I
P
T
L
A
R
K
-
Q
D
E
V
S
S
M
V
S
T
M
A
Q
L
Y
V
Y
G
H
D
L
D
I
R
T
L
F
S
R
A
S
---
G
P
Q
D
Y
A
N
---
I
P
P
T
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
77.67
99%
-86
- C2 -
3TZZ
6
?
A:
[26-488]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
P
G
V
T
E
E
A
L
R
L
K
E
A
A
L
E
E
L
A
A
Q
E
V
T
A
P
L
V
P
L
A
V
S
A
F
L
T
S
R
K
K
A
A
A
A
E
L
A
D
W
M
-----
Q
S
P
E
--
G
-----
Q
A
S
S
L
E
S
I
G
R
S
L
-
S
-
R
R
N
H
G
-
R
S
R
A
V
V
L
A
H
D
H
D
E
A
I
K
G
L
R
A
V
A
A
G
K
Q
A
P
N
V
F
S
V
D
G
P
V
T
T
G
P
--
V
W
V
L
A
G
F
G
A
Q
H
R
K
M
G
K
S
L
Y
L
R
N
E
V
F
A
A
W
I
E
K
V
D
A
L
V
Q
D
E
L
G
Y
S
V
L
E
L
I
L
--
D
D
--
A
--
Q
D
Y
G
---
I
E
T
T
Q
V
T
I
F
A
I
Q
I
A
L
G
E
L
L
R
H
H
G
A
K
P
A
A
V
I
G
Q
S
L
G
E
A
A
S
A
Y
F
A
G
G
L
S
L
R
D
A
T
R
A
I
C
S
R
S
H
L
M
----
G
E
G
E
A
M
L
F
G
E
Y
I
R
L
M
A
L
V
E
Y
S
A
D
E
I
R
E
V
F
S
D
--
F
-
P
D
-
L
E
V
C
V
Y
A
A
P
T
Q
T
V
I
G
G
P
P
E
Q
V
D
A
I
L
A
R
A
E
A
E
G
K
F
A
R
K
F
A
T
-
K
-
G
-
A
S
H
T
S
Q
M
D
P
L
L
G
E
L
T
A
E
L
Q
G
I
--
K
P
--
T
S
P
T
C
G
I
F
S
T
V
H
E
G
R
Y
I
K
P
G
G
E
P
I
H
D
V
E
Y
W
K
K
G
L
R
H
S
V
Y
F
T
H
G
I
R
N
A
V
D
S
G
H
T
T
F
L
E
L
A
P
N
P
V
A
L
M
Q
V
A
L
T
T
A
D
A
-
G
--
L
H
D
A
Q
L
I
P
T
L
A
R
K
-
Q
D
E
V
S
S
M
V
S
T
M
A
Q
L
Y
V
Y
G
H
D
L
D
I
R
T
L
F
S
R
A
S
---
G
P
Q
D
Y
A
N
---
I
P
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
PsiBlast_CBE
77.57
99%
-86
- C2 -
3TZX
7
?
B:
[25-491]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
G
V
T
E
E
A
L
R
L
K
E
A
A
L
E
E
L
A
A
Q
E
V
T
A
P
L
V
P
L
A
V
S
A
F
L
T
S
R
K
K
A
A
A
A
E
L
A
D
W
M
-----
Q
S
P
E
--
G
-----
Q
A
S
S
L
E
S
I
G
R
S
L
-
S
-
R
R
N
H
G
-
R
S
R
A
V
V
L
A
H
D
H
D
E
A
I
K
G
L
R
A
V
A
A
G
K
Q
A
P
N
V
F
S
V
D
G
P
V
T
T
G
P
--
V
W
V
L
A
G
F
G
A
Q
H
R
K
M
G
K
S
L
Y
L
R
N
E
V
F
A
A
W
I
E
K
V
D
A
L
V
Q
D
E
L
G
Y
S
V
L
E
L
I
L
--
D
D
--
A
--
Q
D
Y
G
---
I
E
T
T
Q
V
T
I
F
A
I
Q
I
A
L
G
E
L
L
R
H
H
G
A
K
P
A
A
V
I
G
Q
S
L
G
E
A
A
S
A
Y
F
A
G
G
L
S
L
R
D
A
T
R
A
I
C
S
R
S
H
L
M
----
G
E
G
E
A
M
L
F
G
E
Y
I
R
L
M
A
L
V
E
Y
S
A
D
E
I
R
E
V
F
S
D
--
F
-
P
D
-
L
E
V
C
V
Y
A
A
P
T
Q
T
V
I
G
G
P
P
E
Q
V
D
A
I
L
A
R
A
E
A
E
G
K
F
A
R
K
F
A
T
-
K
-
G
-
A
S
H
T
S
Q
M
D
P
L
L
G
E
L
T
A
E
L
Q
G
I
--
K
P
--
T
S
P
T
C
G
I
F
S
T
V
H
E
G
R
Y
I
K
P
G
G
E
P
I
H
D
V
E
Y
W
K
K
G
L
R
H
S
V
Y
F
T
H
G
I
R
N
A
V
D
S
G
H
T
T
F
L
E
L
A
P
N
P
V
A
L
M
Q
V
A
L
T
T
A
D
A
-
G
--
L
H
D
A
Q
L
I
P
T
L
A
R
K
-
Q
D
E
V
S
S
M
V
S
T
M
A
Q
L
Y
V
Y
G
H
D
L
D
I
R
T
L
F
S
R
A
S
---
G
P
Q
D
Y
A
N
---
I
P
P
T
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
PsiBlast_CBE
77.45
99%
-85
- C2 -
3TZZ
7
?
B:
[27-491]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
G
V
T
E
E
A
L
R
L
K
E
A
A
L
E
E
L
A
A
Q
E
V
T
A
P
L
V
P
L
A
V
S
A
F
L
T
S
R
K
K
A
A
A
A
E
L
A
D
W
M
-----
Q
S
P
E
--
G
-----
Q
A
S
S
L
E
S
I
G
R
S
L
-
S
-
R
R
N
H
G
-
R
S
R
A
V
V
L
A
H
D
H
D
E
A
I
K
G
L
R
A
V
A
A
G
K
Q
A
P
N
V
F
S
V
D
G
P
V
T
T
G
P
--
V
W
V
L
A
G
F
G
A
Q
H
R
K
M
G
K
S
L
Y
L
R
N
E
V
F
A
A
W
I
E
K
V
D
A
L
V
Q
D
E
L
G
Y
S
V
L
E
L
I
L
--
D
D
--
A
--
Q
D
Y
G
---
I
E
T
T
Q
V
T
I
F
A
I
Q
I
A
L
G
E
L
L
R
H
H
G
A
K
P
A
A
V
I
G
Q
S
L
G
E
A
A
S
A
Y
F
A
G
G
L
S
L
R
D
A
T
R
A
I
C
S
R
S
H
L
M
----
G
E
G
E
A
M
L
F
G
E
Y
I
R
L
M
A
L
V
E
Y
S
A
D
E
I
R
E
V
F
S
D
--
F
-
P
D
-
L
E
V
C
V
Y
A
A
P
T
Q
T
V
I
G
G
P
P
E
Q
V
D
A
I
L
A
R
A
E
A
E
G
K
F
A
R
K
F
A
T
-
K
-
G
-
A
S
H
T
S
Q
M
D
P
L
L
G
E
L
T
A
E
L
Q
G
I
--
K
P
--
T
S
P
T
C
G
I
F
S
T
V
H
E
G
R
Y
I
K
P
G
G
E
P
I
H
D
V
E
Y
W
K
K
G
L
R
H
S
V
Y
F
T
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I
R
N
A
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D
S
G
H
T
T
F
L
E
L
A
P
N
P
V
A
L
M
Q
V
A
L
T
T
A
D
A
-
G
--
L
H
D
A
Q
L
I
P
T
L
A
R
K
-
Q
D
E
V
S
S
M
V
S
T
M
A
Q
L
Y
V
Y
G
H
D
L
D
I
R
T
L
F
S
R
A
S
---
G
P
Q
D
Y
A
N
---
I
P
P
T
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
77.28
99%
-86
- C2 -
3TZW
12
?
A:
[25-491]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
L
P
G
V
T
E
E
A
L
R
L
K
E
A
A
L
E
E
L
A
A
Q
E
V
T
A
P
L
V
P
L
A
V
S
A
F
L
T
S
R
K
K
A
A
A
A
E
L
A
D
W
M
-----
Q
S
P
E
--
G
-----
Q
A
S
S
L
E
S
I
G
R
S
L
-
S
-
R
R
N
H
G
-
R
S
R
A
V
V
L
A
H
D
H
D
E
A
I
K
G
L
R
A
V
A
A
G
K
Q
A
P
N
V
F
S
V
D
G
P
V
T
T
G
P
--
V
W
V
L
A
G
F
G
A
Q
H
R
K
M
G
K
S
L
Y
L
R
N
E
V
F
A
A
W
I
E
K
V
D
A
L
V
Q
D
E
L
G
Y
S
V
L
E
L
I
L
--
D
D
--
A
--
Q
D
Y
G
---
I
E
T
T
Q
V
T
I
F
A
I
Q
I
A
L
G
E
L
L
R
H
H
G
A
K
P
A
A
V
I
G
Q
S
L
G
E
A
A
S
A
Y
F
A
G
G
L
S
L
R
D
A
T
R
A
I
C
S
R
S
H
L
M
----
G
E
G
E
A
M
L
F
G
E
Y
I
R
L
M
A
L
V
E
Y
S
A
D
E
I
R
E
V
F
S
D
--
F
-
P
D
-
L
E
V
C
V
Y
A
A
P
T
Q
T
V
I
G
G
P
P
E
Q
V
D
A
I
L
A
R
A
E
A
E
G
K
F
A
R
K
F
A
T
-
K
-
G
-
A
S
H
T
S
Q
M
D
P
L
L
G
E
L
T
A
E
L
Q
G
I
--
K
P
--
T
S
P
T
C
G
I
F
S
T
V
H
E
G
R
Y
I
K
P
G
G
E
P
I
H
D
V
E
Y
W
K
K
G
L
R
H
S
V
Y
F
T
H
G
I
R
N
A
V
D
S
G
H
T
T
F
L
E
L
A
P
N
P
V
A
L
M
Q
V
A
L
T
T
A
D
A
-
G
--
L
H
D
A
Q
L
I
P
T
L
A
R
K
-
Q
D
E
V
S
S
M
V
S
T
M
A
Q
L
Y
V
Y
G
H
D
L
D
I
R
T
L
F
S
R
A
S
---
G
P
Q
D
Y
A
N
---
I
P
P
T
R
F
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
77.21
99%
-84
- C2 -
3TZX
3
?
A:
[24-488]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
E
L
P
G
V
T
E
E
A
L
R
L
K
E
A
A
L
E
E
L
A
A
Q
E
V
T
A
P
L
V
P
L
A
V
S
A
F
L
T
S
R
K
K
A
A
A
A
E
L
A
D
W
M
-----
Q
S
P
E
--
G
-----
Q
A
S
S
L
E
S
I
G
R
S
L
-
S
-
R
R
N
H
G
-
R
S
R
A
V
V
L
A
H
D
H
D
E
A
I
K
G
L
R
A
V
A
A
G
K
Q
A
P
N
V
F
S
V
D
G
P
V
T
T
G
P
--
V
W
V
L
A
G
F
G
A
Q
H
R
K
M
G
K
S
L
Y
L
R
N
E
V
F
A
A
W
I
E
K
V
D
A
L
V
Q
D
E
L
G
Y
S
V
L
E
L
I
L
--
D
D
--
A
--
Q
D
Y
G
---
I
E
T
T
Q
V
T
I
F
A
I
Q
I
A
L
G
E
L
L
R
H
H
G
A
K
P
A
A
V
I
G
Q
S
L
G
E
A
A
S
A
Y
F
A
G
G
L
S
L
R
D
A
T
R
A
I
C
S
R
S
H
L
M
----
G
E
G
E
A
M
L
F
G
E
Y
I
R
L
M
A
L
V
E
Y
S
A
D
E
I
R
E
V
F
S
D
--
F
-
P
D
-
L
E
V
C
V
Y
A
A
P
T
Q
T
V
I
G
G
P
P
E
Q
V
D
A
I
L
A
R
A
E
A
E
G
K
F
A
R
K
F
A
T
-
K
-
G
-
A
S
H
T
S
Q
M
D
P
L
L
G
E
L
T
A
E
L
Q
G
I
--
K
P
--
T
S
P
T
C
G
I
F
S
T
V
H
E
G
R
Y
I
K
P
G
G
E
P
I
H
D
V
E
Y
W
K
K
G
L
R
H
S
V
Y
F
T
H
G
I
R
N
A
V
D
S
G
H
T
T
F
L
E
L
A
P
N
P
V
A
L
M
Q
V
A
L
T
T
A
D
A
-
G
--
L
H
D
A
Q
L
I
P
T
L
A
R
K
-
Q
D
E
V
S
S
M
V
S
T
M
A
Q
L
Y
V
Y
G
H
D
L
D
I
R
T
L
F
S
R
A
S
---
G
P
Q
D
Y
A
N
---
I
P
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
55
HHSearch
76.42
100%
-90
- C2 -
3TZY
7
?
A:
[50-488]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
A
P
L
V
P
L
A
V
S
A
F
L
T
S
R
K
K
A
A
A
A
E
L
A
D
W
M
-----
Q
S
P
E
--
G
-----
Q
A
S
S
L
E
S
I
G
R
S
L
-
S
-
R
R
N
H
G
-
R
S
R
A
V
V
L
A
H
D
H
D
E
A
I
K
G
L
R
A
V
A
A
G
K
Q
A
P
N
V
F
S
V
D
G
P
V
T
T
G
P
--
V
W
V
L
A
G
F
G
A
Q
H
R
K
M
G
K
S
L
Y
L
R
N
E
V
F
A
A
W
I
E
K
V
D
A
L
V
Q
D
E
L
G
Y
S
V
L
E
L
I
L
--
D
D
--
A
--
Q
D
Y
G
---
I
E
T
T
Q
V
T
I
F
A
I
Q
I
A
L
G
E
L
L
R
H
H
G
A
K
P
A
A
V
I
G
Q
S
L
G
E
A
A
S
A
Y
F
A
G
G
L
S
L
R
D
A
T
R
A
I
C
S
R
S
H
L
M
----
G
E
G
E
A
M
L
F
G
E
Y
I
R
L
M
A
L
V
E
Y
S
A
D
E
I
R
E
V
F
S
D
--
F
-
P
D
-
L
E
V
C
V
Y
A
A
P
T
Q
T
V
I
G
G
P
P
E
Q
V
D
A
I
L
A
R
A
E
A
E
G
K
F
A
R
K
F
A
T
-
K
-
G
-
A
S
H
T
S
Q
M
D
P
L
L
G
E
L
T
A
E
L
Q
G
I
--
K
P
--
T
S
P
T
C
G
I
F
S
T
V
H
E
G
R
Y
I
K
P
G
G
E
P
I
H
D
V
E
Y
W
K
K
G
L
R
H
S
V
Y
F
T
H
G
I
R
N
A
V
D
S
G
H
T
T
F
L
E
L
A
P
N
P
V
A
L
M
Q
V
A
L
T
T
A
D
A
-
G
--
L
H
D
A
Q
L
I
P
T
L
A
R
K
-
Q
D
E
V
S
S
M
V
S
T
M
A
Q
L
Y
V
Y
G
H
D
L
D
I
R
T
L
F
S
R
A
S
---
G
P
Q
D
Y
A
N
---
I
P
P
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
41
HHSearch
74.29
28%
-59
- C2 -
3HHD
-
FAS_HUMAN
A:
[3-854]
-------------------------------------------------------------------------------------------------------------------
G
E
E
V
V
I
A
G
M
S
G
K
L
P
E
S
-
E
N
L
Q
E
F
W
D
N
L
I
G
G
V
D
M
V
T
D
-
D
D
R
R
W
--
K
A
G
L
-
Y
----------
G
L
P
R
R
S
G
K
L
K
D
L
S
R
F
D
A
S
F
F
G
V
H
P
K
Q
A
H
T
M
D
P
Q
L
R
L
L
L
E
V
T
Y
E
A
I
V
D
G
G
I
N
P
D
S
L
-------
R
G
T
H
T
G
V
W
V
G
V
S
G
S
E
T
S
E
A
L
S
R
D
P
----
E
-
T
L
V
G
Y
S
M
V
-
G
C
Q
R
A
M
M
A
N
R
L
S
F
F
F
D
F
R
G
P
S
I
A
L
D
T
A
C
S
S
S
L
M
A
L
Q
N
A
Y
Q
A
I
H
S
G
Q
C
P
A
A
I
V
G
G
I
N
V
L
L
K
P
N
T
S
V
Q
F
L
R
L
-
G
M
L
S
P
E
G
T
C
K
A
F
D
T
A
G
N
G
Y
C
R
S
E
G
V
V
A
V
L
L
T
K
K
S
L
A
R
----
R
V
Y
A
T
I
L
N
A
G
T
N
T
D
G
-
F
K
E
-
Q
G
V
T
F
P
S
G
D
I
Q
E
Q
L
I
R
S
L
Y
Q
S
A
G
V
A
P
E
S
F
E
Y
I
E
A
H
G
T
G
T
K
V
G
D
P
Q
E
L
N
G
I
T
R
A
L
C
A
T
R
---------
Q
E
P
L
L
I
G
S
T
K
S
N
M
G
H
P
E
P
A
S
G
L
A
A
L
A
K
V
L
L
S
L
E
H
G
L
W
A
P
N
L
H
F
H
S
P
N
P
E
I
P
A
L
L
D
G
R
L
Q
V
V
D
Q
P
L
P
V
R
-
G
----------
G
N
V
G
I
N
S
F
G
F
G
G
S
N
V
H
I
I
L
R
P
N
T
Q
P
P
P
A
P
--------------------------------------------------------------------
A
P
H
A
T
L
P
R
L
L
R
A
S
G
R
T
P
E
A
V
Q
K
L
L
E
Q
G
L
R
H
S
-----
Q
D
L
A
--------
F
L
S
M
L
N
D
I
A
A
V
----
P
A
T
A
M
-
P
F
R
G
Y
A
V
L
G
G
E
R
G
G
P
E
V
Q
--------------
Q
V
P
A
G
E
R
P
L
--
W
F
I
C
S
G
M
G
T
Q
W
R
G
M
G
L
S
L
M
R
-
L
D
R
F
R
D
S
I
L
R
S
D
E
A
V
K
P
-
F
G
L
K
V
S
Q
L
L
L
--
S
T
--
D
ES
T
F
D
D
---
I
V
H
S
F
V
S
L
T
A
I
Q
I
G
L
I
D
L
L
S
C
M
G
L
R
P
D
G
I
V
G
H
S
L
G
E
V
A
C
G
Y
A
D
G
C
L
S
Q
E
E
A
V
L
A
A
Y
W
R
G
Q
C
I
----
K
E
A
H
L
-----
P
P
G
A
M
A
A
V
G
L
S
W
E
E
C
K
Q
R
C
P
-----
P
G
-
V
V
P
A
C
H
N
S
K
D
T
V
T
I
S
G
P
Q
A
P
V
F
E
F
V
E
Q
L
R
K
E
G
V
F
A
K
E
V
R
T
G
G
-
M
-
A
F
H
S
Y
F
M
E
A
I
A
P
P
L
L
Q
E
L
K
K
V
--
I
R
E
P
K
P
R
S
A
R
W
L
S
T
S
I
P
E
A
Q
W
H
S
S
L
A
R
T
S
S
A
E
Y
N
V
N
N
L
V
S
P
V
L
F
Q
E
A
L
W
H
V
P
--
E
H
A
V
V
L
E
I
A
P
H
A
L
L
Q
A
V
L
K
R
G
L
K
P
-------
S
C
T
I
I
P
L
M
K
K
D
H
R
D
N
L
E
F
F
L
A
G
I
G
R
L
H
L
S
G
I
D
A
N
P
N
A
L
F
P
P
V
E
F
PA
P
R
G
T
P
L
I
---
S
P
L
I
K
W
D
H
S
L
A
W
D
V
P
A
A
E
------
D
F
P
N
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
66
Fugue
72.86
22%
-54
- C2 -
2VZ8
-
?
A:
[1-2113]
-------------------------------------------------------------------------------------------------------------------
M
E
E
V
V
I
A
G
M
S
G
K
L
P
E
-
S
E
N
L
E
E
F
W
A
N
L
I
G
G
V
D
M
V
T
A
-
D
D
R
R
W
--
K
A
-----------
G
L
Y
G
L
P
R
R
M
G
K
L
K
D
L
S
R
F
D
A
S
F
F
G
V
H
S
K
Q
A
N
T
M
D
P
Q
L
R
M
L
L
E
V
T
Y
E
A
I
V
D
G
G
I
N
P
A
S
L
-------
R
G
T
S
T
G
V
W
V
G
V
S
S
S
D
A
S
E
A
L
S
R
D
P
----
E
-
T
L
V
G
Y
S
M
I
-
G
C
Q
R
A
M
M
A
N
R
L
S
F
F
F
D
F
K
G
P
S
I
T
I
D
T
A
C
S
S
S
L
L
A
L
Q
S
A
Y
Q
A
I
R
G
G
E
C
S
A
A
V
V
G
G
L
N
V
L
L
K
P
N
S
S
L
Q
F
M
K
L
G
M
-
L
S
Q
D
G
T
C
R
S
F
D
A
E
G
T
G
Y
C
R
A
E
A
V
V
A
V
L
L
T
K
K
S
L
A
R
R
----
V
Y
A
T
I
L
N
A
G
T
N
T
D
G
S
K
-
E
-
Q
G
V
T
F
P
S
G
D
V
Q
E
Q
L
I
R
S
L
Y
A
P
A
G
P
D
P
E
S
L
E
Y
I
E
A
H
G
T
G
T
K
V
G
D
P
Q
E
L
N
G
I
V
N
A
L
C
A
T
R
R
---------
E
P
L
L
I
G
S
T
K
S
N
M
G
H
P
E
P
A
S
G
V
A
A
L
I
K
V
L
L
S
L
E
H
G
V
W
A
P
N
L
H
Y
H
T
P
N
P
E
I
P
A
L
Q
D
G
R
L
Q
V
V
D
R
P
L
P
I
R
-
G
----------
G
N
V
G
I
N
S
F
G
F
G
G
S
N
V
H
V
I
L
Q
P
N
S
R
P
A
P
P
P
A
Q
H
A
A
L
P
------------------------------------------------------------------------
R
L
L
Q
A
S
G
R
T
L
E
A
V
Q
T
L
L
E
Q
G
-----
L
R
H
S
--
R
-----
D
L
A
F
V
G
M
L
N
E
I
A
-
A
-
V
S
P
V
A
M
P
F
R
G
Y
A
V
L
G
--------------
G
E
A
G
S
Q
E
V
Q
Q
V
P
G
S
K
R
P
V
--
W
F
I
C
S
G
M
G
A
Q
W
Q
G
M
G
L
S
L
M
-
R
L
D
R
F
R
D
S
I
L
R
S
D
Q
A
L
K
P
L
-
G
L
R
V
S
D
L
L
L
S
T
D
E
--
A
--
V
L
D
D
---
I
V
S
S
F
V
S
L
T
S
I
Q
I
A
L
I
D
L
L
T
S
L
G
L
Q
P
D
G
I
I
G
H
S
L
G
E
V
A
C
G
Y
A
D
G
C
L
T
Q
E
E
A
V
L
S
S
Y
W
R
G
Y
C
I
----
K
E
-----
A
N
V
L
P
G
A
M
A
A
V
G
L
S
W
E
E
C
K
Q
R
C
P
-----
P
G
-
I
V
P
A
C
H
N
S
K
D
T
V
T
I
S
G
P
Q
A
A
M
S
E
F
L
Q
Q
L
K
R
E
D
V
F
V
K
E
V
R
T
-
G
-
G
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A
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Y
F
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E
S
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A
P
T
L
L
R
Q
L
R
K
V
I
L
D
P
--
K
P
R
S
K
R
W
L
S
T
S
I
P
E
A
Q
W
Q
G
S
L
A
R
T
F
S
A
E
Y
S
V
N
N
L
V
S
P
V
L
F
Q
E
A
L
Q
H
V
--
P
A
H
A
V
V
V
E
I
A
P
H
A
L
L
Q
A
V
L
K
R
S
L
E
S
S
-------
C
T
I
I
P
L
M
K
K
D
H
R
D
N
L
E
F
F
L
S
N
V
G
R
L
H
L
A
G
V
S
V
N
P
N
G
L
F
P
P
V
E
---
F
P
A
P
R
G
T
PLI
S
P
H
I
K
W
D
H
S
Q
A
W
D
V
P
S
A
A
DFPSGS
S
C
S
S
V
A
V
Y
K
F
D
V
S
P
E
S
P
D
H
Y
L
V
D
H
C
I
D
G
R
V
L
F
P
G
T
G
Y
L
W
L
T
W
K
T
L
A
R
A
L
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Q
N
L
E
E
T
P
V
V
F
E
D
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T
L
H
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A
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L
P
K
T
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T
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S
L
E
V
R
L
L
E
A
S
H
A
F
E
V
S
D
S
N
G
S
L
I
A
S
G
K
V
Y
Q
W
E
S
P
D
P
K
L
F
D
T
R
A
A
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D
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A
D
S
T
A
E
F
R
L
S
Q
G
D
V
Y
K
D
L
R
L
R
-------------
G
Y
D
Y
G
P
F
F
Q
L
V
L
E
S
D
L
E
G
N
R
G
R
L
Q
W
N
D
S
W
V
S
F
-
L
D
A
M
L
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M
S
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LAPG
Q
L
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L
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L
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V
T
H
R
Q
K
L
Y
T
L
QDT
T
Q
A
A
D
V
V
V
D
R
N
L
N
T
V
V
A
GG
A
L
F
L
G
A
H
S
S
V
A
P
R
R
P
Q
E
H
L
K
P
I
L
E
K
F
C
F
T
P
H
V
E
S
G
C
L
A
G
N
T
A
L
L
S
G
L
L
D
A
P
A
L
K
A
C
V
D
T
A
L
E
N
M
-
A
S
P
K
M
K
V
V
E
V
L
A
G
D
G
Q
L
Y
S
R
I
P
A
L
L
N
T
Q
P
V
M
D
L
D
Y
T
A
T
D
R
N
P
Q
A
L
E
A
A
Q
A
K
L
E
Q
L
H
V
T
Q
G
Q
W
D
P
A
N
P
A
P
A
D
L
L
V
C
N
C
A
G
G
F
L
L
L
H
T
L
D
Q
W
E
S
L
F
A
G
A
S
L
H
L
V
A
L
K
R
S
F
Y
G
S
V
L
F
L
C
R
Q
Q
T
P
Q
D
S
P
V
F
L
S
V
E
D
T
S
F
R
W
V
D
S
L
K
D
I
L
A
D
----
A
S
S
R
P
V
W
L
M
A
V
G
C
S
T
S
G
V
V
G
M
V
N
C
L
R
K
E
P
G
G
H
R
I
R
C
V
L
V
S
N
L
S
S
T
S
P
A
P
E
M
H
P
S
S
S
E
L
Q
K
V
L
Q
G
D
L
V
M
N
V
Y
R
D
G
A
W
G
A
F
R
H
F
P
L
E
Q
D
R
P
E
K
Q
T
E
H
A
F
V
N
V
L
S
R
G
--------
D
L
S
S
I
R
W
V
C
S
P
L
H
Y
A
L
P
A
S
C
Q
D
R
L
C
S
V
Y
Y
T
S
L
N
F
R
D
V
M
L
A
T
G
K
L
S
P
D
S
I
P
G
K
WLTRDC
M
L
G
M
E
F
S
G
--
R
D
A
S
G
R
R
V
M
G
M
V
P
A
E
G
L
A
T
S
V
L
L
L
Q
H
A
T
W
E
V
P
S
T
W
T
L
E
E
A
A
S
VPI
V
Y
T
T
A
Y
Y
S
LVVRGRMQPG
E
S
V
L
I
H
SGSG
G
V
G
Q
A
A
I
A
I
A
L
S
R
GCR
V
F
T
T
V
GS
A
E
K
R
A
Y
L
Q
A
R
F
PQLDETCFANSRDT
S
F
E
Q
H
V
L
R
H
T
A
GKGVDLVLNSLA
E
E
K
L
Q
A
S
V
R
C
LAQH
G
R
F
L
E
IGK
F
D
L
S
N
NHALGMAVFLKN
V
T
F
H
G
I
L
LDSLFEEGG
A
T
W
Q
E
V
S
E
L
L
K
A
G
I
Q
E
GV
V
Q
P
L
KCTVFPRTK
V
E
A
A
F
R
Y
M
A
Q
GKHI
G
K
V
V
I
Q
VREEEQGPAPR
G
L
P
P
I
A
L
T
G
L
S
K
T
F
C
PPH
K
S
Y
V
I
T
GGLG
G
F
G
L
Q
L
A
Q
W
L
R
L
R
GAQ
K
L
V
L
T
S
RSGIRT
G
Y
Q
A
R
Q
V
R
E
W
R
R
Q
GV
Q
V
L
V
S
TSNASS
L
D
G
A
R
S
L
I
T
E
A
T
Q
L
GPVG
G
V
F
N
LAMVVSKPK
Y
S
G
T
A
N
L
D
R
V
T
R
E
ACPELD
Y
F
V
I
F
S
S
VSCGRGNAGQ
A
N
Y
G
F
A
N
S
A
M
E
R
I
C
E
K
R
R
H
D
G
L
P
G
L
A
V
QWGAIGDVGVVLENDTVIGGTLPQR
I
A
S
C
L
E
V
L
D
L
F
L
S
QPHP
V
L
S
S
F
V
L
A
E
42
HHSearch
72.36
29%
-61
* C2 *
2VZ8
-
?
A:
[2-997]
--------------------------------------------------------------------------------------------------------------------
E
E
V
V
I
A
G
M
S
G
K
L
P
E
S
-
E
N
L
E
E
F
W
A
N
L
I
G
G
V
D
M
V
T
A
D
-
D
R
R
W
--
K
A
G
L
-
Y
----------
G
L
P
R
R
M
G
K
L
K
D
L
S
R
F
D
A
S
F
F
G
V
H
S
K
Q
A
N
T
M
D
P
Q
L
R
M
L
L
E
V
T
Y
E
A
I
V
D
G
G
I
N
P
A
S
L
-------
R
G
T
S
T
G
V
W
V
G
V
S
S
S
D
A
S
E
A
L
S
R
D
P
----
E
-
T
L
V
G
Y
S
M
I
-
G
C
Q
R
A
M
M
A
N
R
L
S
F
F
F
D
F
K
G
P
S
I
T
I
D
T
A
C
S
S
S
L
L
A
L
Q
S
A
Y
Q
A
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R
G
G
E
C
S
A
A
V
V
G
G
L
N
V
L
L
K
P
N
S
S
L
Q
F
M
K
L
-
G
M
L
S
Q
D
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C
R
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F
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A
E
G
T
G
Y
C
R
A
E
A
V
V
A
V
L
L
T
K
K
S
L
A
R
----
R
V
Y
A
T
I
L
N
A
G
T
N
T
D
G
-
S
K
E
-
Q
G
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F
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G
D
V
Q
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Q
L
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L
Y
A
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A
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L
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G
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G
T
K
V
G
D
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Q
E
L
N
G
I
V
N
A
L
C
A
T
R
---------
R
E
P
L
L
I
G
S
T
K
S
N
M
G
H
P
E
P
A
S
G
V
A
A
L
I
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V
L
L
S
L
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H
G
V
W
A
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N
L
H
Y
H
T
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N
P
E
I
P
A
L
Q
D
G
R
L
Q
V
V
D
R
P
L
P
I
R
-----------
G
G
N
V
G
I
N
S
F
G
F
G
G
S
N
V
H
V
I
L
Q
P
N
S
R
P
A
P
P
P
--------------------------------------------------------------------
A
Q
H
A
A
L
P
R
L
L
Q
A
S
G
R
T
L
E
A
V
Q
T
L
L
E
Q
G
L
R
H
S
-----
R
D
L
-----------
A
F
V
G
M
L
N
E
I
A
-
A
V
S
P
V
A
M
-
P
F
R
G
Y
A
V
L
G
G
E
A
G
S
Q
E
V
Q
--------------
Q
V
P
G
S
K
R
P
V
--
W
F
I
C
S
G
M
G
A
Q
W
Q
G
M
G
L
S
L
M
R
-
L
D
R
F
R
D
S
I
L
R
S
D
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A
L
K
P
-
L
G
L
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V
S
D
L
L
L
--
S
T
D
E
A
--
V
L
D
D
---
I
V
S
S
F
V
S
L
T
S
I
Q
I
A
L
I
D
L
L
T
S
L
G
L
Q
P
D
G
I
I
G
H
S
L
G
E
V
A
C
G
Y
A
D
G
C
L
T
Q
E
E
A
V
L
S
S
Y
W
R
G
Y
C
I
----
K
E
A
N
V
-----
L
P
G
A
M
A
A
V
G
L
S
W
E
E
C
K
Q
R
C
P
-----
P
G
-
I
V
P
A
C
H
N
S
K
D
T
V
T
I
S
G
P
Q
A
A
M
S
E
F
L
Q
Q
L
K
R
E
D
V
F
V
K
E
V
R
T
-
G
G
I
-
A
F
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S
Y
F
M
E
S
I
A
P
T
L
L
R
Q
L
R
K
V
--
I
L
D
P
K
P
R
S
K
R
W
L
S
T
S
I
P
E
A
Q
W
Q
G
S
L
A
R
T
F
S
A
E
Y
S
V
N
N
L
V
S
P
V
L
F
Q
E
A
L
Q
H
V
P
A
--
H
A
V
V
V
E
I
A
P
H
A
L
L
Q
A
V
L
K
R
S
L
E
S
S
-------
C
T
I
I
P
L
M
K
K
D
H
R
D
N
L
E
F
F
L
S
N
V
G
R
L
H
L
A
G
V
S
V
N
P
N
G
L
F
P
P
V
E
FPA
P
R
G
T
P
L
I
---
S
P
H
I
K
W
D
H
S
Q
A
W
D
V
P
S
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
48
HHSearch
60.70
39%
-47
- C2 -
4NA1
2
PKSJ_BACSU
A:
[22-547]
------------------------------------------------------------------------------------------------------------------
D
F
E
P
V
A
I
V
G
I
S
G
R
F
P
G
A
-
M
D
I
D
E
F
W
K
N
L
E
E
G
K
D
S
I
T
E
V
P
K
D
R
W
--
D
W
R
E
-
H
Y
G
N
P
D
T
D
V
N
K
T
D
I
K
W
G
G
F
I
D
G
V
A
E
F
D
P
L
F
F
G
I
S
P
R
E
A
D
Y
V
D
P
Q
Q
R
L
L
M
T
Y
V
W
K
A
L
E
D
A
G
C
S
P
Q
S
L
-------
S
G
T
G
T
G
I
F
I
G
T
G
N
T
G
Y
K
D
L
F
H
R
A
N
----
L
-
P
I
E
G
H
A
A
T
G
H
M
I
P
S
V
G
P
N
R
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Y
F
L
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P
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A
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A
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G
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A
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A
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G
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I
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A
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Y
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A
-
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M
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R
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K
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S
A
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A
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E
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G
M
V
M
L
K
K
L
E
D
A
E
R
D
G
N
H
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Y
G
V
I
R
G
T
A
E
N
H
G
G
-
R
-
A
-
N
T
L
T
S
P
N
P
K
A
Q
A
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L
L
V
R
A
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R
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A
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L
G
D
P
I
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I
N
G
L
K
A
A
F
K
E
L
S
N
MDV----
P
D
H
R
C
G
I
G
S
V
K
S
N
I
G
H
L
E
L
A
A
G
I
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G
L
I
K
V
L
L
Q
M
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H
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L
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C
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T
L
N
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Y
L
Q
-
L
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Y
I
V
Q
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K
Q
E
W
K
-
S
V
T
D
RDG
N
E
L
P
R
R
A
G
I
S
S
F
G
I
G
G
V
N
A
H
I
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I
E
E
Y
M
P
-----------------------------------------------------------------------------
E
Q
P
N
V
I
V
L
S
A
K
N
K
S
R
L
I
D
R
A
S
Q
L
L
E
V
I
-----
R
N
K
K
--
Y
-----
T
D
Q
D
L
H
R
I
A
Y
T
L
-
Q
V
G
R
E
E
M
-
D
E
R
L
A
C
V
A
G
T
M
Q
E
L
E
E
K
L
Q
A
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
46
HHSearch
60.02
34%
-57
- C2 -
4OQJ
3
?
A:
[19-624]
------------------------------------------------------------------------------------------------------------------
R
D
S
D
I
A
V
I
G
L
A
C
R
F
P
G
A
-
A
T
P
D
T
F
W
K
V
L
S
E
G
R
E
T
L
T
H
F
S
D
E
E
L
--
R
A
A
G
-
V
-
A
E
P
-
L
L
A
D
D
R
Y
V
K
A
G
Q
V
L
V
D
A
D
K
F
D
A
G
L
F
G
I
T
R
D
E
A
E
L
I
D
P
Q
Q
R
Q
F
L
E
C
A
Y
E
A
L
E
R
A
G
Y
D
P
Q
R
--------
G
E
Q
R
I
G
V
Y
A
G
V
G
L
N
T
Y
L
L
H
N
L
G
E
R
Y
R
T
A
S
S
V
D
R
Y
R
M
M
I
-
T
N
D
K
D
F
V
A
T
R
T
A
Y
K
L
N
L
C
G
P
S
V
S
T
N
T
A
C
S
T
S
L
V
A
V
H
L
A
C
L
S
L
L
S
G
D
C
T
M
A
L
A
G
A
A
H
I
Q
A
D
Q
G
E
G
Y
L
H
H
E
G
-
M
I
F
S
P
D
G
H
C
R
A
F
D
A
K
A
Q
G
T
V
I
G
N
G
V
G
A
V
V
L
K
R
L
S
D
A
L
A
D
G
D
T
V
H
A
V
I
K
G
T
A
V
N
N
D
G
-
S
-
D
K
T
G
Y
T
A
P
S
V
Q
G
Q
A
A
V
V
A
E
A
Q
E
I
A
D
V
G
P
E
T
V
S
Y
V
E
A
H
G
T
A
T
P
L
G
D
P
I
E
V
A
A
L
N
Q
A
F
N
R
E
G
A
AL-----
A
P
G
S
C
A
L
G
S
V
K
T
N
V
G
H
L
D
T
A
A
G
M
A
G
L
I
K
T
I
L
M
L
R
H
R
T
L
V
P
S
L
C
F
E
A
P
N
P
E
I
D
-
F
A
A
G
P
F
Y
V
G
T
E
T
K
E
W
P
-
A
G
------
P
T
P
R
R
A
G
V
S
S
F
G
I
G
G
T
N
A
H
V
I
V
E
E
P
P
A
V
----------------------------------------------------------------------------
A
G
P
R
L
L
V
L
S
A
N
T
P
A
A
L
D
T
A
T
A
D
L
A
R
A
L
-----
R
K
D
---------
R
D
L
D
L
S
A
V
A
Q
T
L
-
A
L
G
R
R
V
L
-
P
Y
R
R
A
L
V
A
T
G
V
R
D
A
A
L
A
L
A
L
G
D
A
G
R
V
----
M
T
A
G
P
A
D
E
R
P
V
--
V
E
L
V
T
G
G
G
T
P
--
E
H
A
A
A
L
Y
E
E
A
A
A
F
R
E
H
F
D
R
C
A
A
E
L
----
G
T
P
A
A
E
L
L
R
-----------------
G
H
G
P
D
A
A
F
A
V
Q
Y
A
T
A
R
A
L
A
G
W
G
S
T
A
P
V
V
A
A
D
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
45
HHSearch
59.91
37%
-48
- C2 -
5E5N
-
PKSL_BACSU
A:
[3-506]
--------------------------------------------------------------------------------------------------------------------
D
A
I
A
I
V
G
M
S
G
R
Y
P
G
A
-
R
N
V
R
E
Y
W
D
N
L
V
H
A
R
N
A
I
R
D
I
P
T
S
R
W
--
D
V
D
K
-
Y
Y
D
P
V
-----
K
V
Y
C
K
S
M
G
M
L
D
D
I
E
H
F
D
P
L
F
F
N
I
P
P
S
E
A
E
L
M
D
P
Q
H
R
I
F
L
Q
E
G
Y
K
A
F
E
D
A
G
Y
N
A
R
T
L
-------
N
E
K
K
C
G
V
Y
L
G
I
M
S
N
E
Y
G
V
M
L
N
------------------
G
N
S
F
A
I
A
A
A
R
I
P
Y
F
L
N
L
K
G
P
A
I
P
I
D
T
A
S
S
S
S
L
V
G
T
H
L
A
R
Q
A
L
I
N
K
E
I
D
M
A
L
V
G
G
V
S
L
Y
L
T
P
E
S
Y
M
S
M
--
A
-
G
M
L
S
P
D
G
Q
C
K
A
F
D
N
G
A
N
G
F
V
P
G
E
G
A
G
A
L
V
L
K
R
L
K
D
A
E
A
D
R
D
H
I
Y
G
I
I
I
G
S
G
I
N
Q
D
G
-
K
-
T
-
N
G
I
T
A
P
S
A
K
S
Q
M
D
L
E
R
D
I
Y
E
T
Y
G
I
H
P
E
S
I
S
Y
V
E
M
H
G
T
G
T
K
Q
G
D
P
I
E
L
E
A
L
S
T
V
F
Q
E
K
T
D
-------
K
K
Q
F
C
A
I
G
S
V
K
S
N
I
G
H
T
S
A
A
A
G
V
A
G
V
Q
K
V
L
L
C
M
N
H
K
T
L
V
P
T
L
N
F
T
T
P
N
E
H
F
E
-
F
E
H
S
P
L
Y
V
N
T
E
L
K
P
W
E
-
T
A
D-----
G
K
P
R
R
A
C
V
S
S
F
G
Y
S
G
T
N
A
H
I
V
I
E
E
Y
Q
P
E
------------------------------------------------------------------------------
S
A
L
F
V
L
S
A
K
K
E
K
Q
L
K
A
Y
A
E
A
M
K
D
F
V
-----
T
S
N
---------
E
D
I
D
L
E
D
M
A
Y
T
L
-
Q
T
G
R
E
A
M
-
D
Y
R
M
A
F
L
A
D
S
R
E
M
L
I
K
A
L
D
D
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
53
HHSearch
59.62
40%
-46
- C2 -
4QYR
2
?
A:
[6-527]
-------------------------------------------------------------------------------------------------------------------
D
D
A
V
A
I
V
G
A
A
G
R
F
P
G
A
-
D
D
L
D
T
F
W
Q
Q
L
R
A
G
E
D
L
I
A
D
Y
P
G
D
R
F
--
D
G
G
P
-
Y
-
A
E
V
--
V
A
R
A
D
F
P
K
F
A
G
R
I
E
G
V
D
R
F
D
A
D
F
F
H
L
S
R
L
E
A
E
L
M
D
P
Q
H
R
L
A
L
E
T
V
W
A
A
L
E
N
G
G
Y
A
P
A
R
L
--------
P
E
N
T
G
V
Y
F
G
V
S
G
S
D
Y
H
H
L
L
N
A
S
G
----
V
-
A
P
D
G
F
T
A
T
-
G
N
A
H
S
M
L
A
N
R
I
S
Y
V
L
D
V
H
G
P
S
E
P
V
D
T
A
C
S
S
S
L
V
A
L
H
R
A
V
E
H
I
R
S
G
R
C
E
M
A
I
A
G
G
V
N
L
L
L
S
V
D
T
F
A
A
T
H
M
A
-
G
M
L
S
P
D
G
R
C
K
T
F
S
A
G
A
D
G
Y
V
R
S
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G
V
A
A
V
L
L
K
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L
A
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A
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R
D
G
D
A
I
W
G
V
V
R
G
S
A
E
N
H
G
G
-
R
-
A
-
G
S
L
T
A
P
N
G
K
A
Q
A
A
L
I
Q
D
A
M
R
--
G
I
D
P
D
S
I
G
Y
V
E
A
H
G
T
G
T
G
L
G
D
P
V
E
V
N
A
L
D
S
A
Y
R
A
L
R
T
A
E
GGPPH
A
A
R
P
C
A
L
G
S
V
K
T
N
I
G
H
A
E
S
A
A
G
L
A
G
V
L
K
V
L
L
A
M
R
H
R
E
L
P
P
A
L
H
C
D
R
L
N
P
H
L
P
-
L
D
G
-
G
F
E
V
V
R
E
L
R
R
W
E
-
P
C
T
D
ATGR
P
W
P
L
R
A
G
V
S
S
F
G
F
G
G
A
N
A
H
V
V
L
E
A
P
P
V
P
P
A
---------------------------------------------------------------------------
A
P
Q
A
I
V
L
S
A
R
D
D
D
R
L
R
A
T
A
G
R
L
R
D
F
L
-----
D
R
A
R
R
D
G
-----
H
A
P
D
L
A
D
L
A
F
T
L
-
Q
V
G
R
E
A
M
-
E
R
R
L
G
F
V
V
G
S
M
D
D
V
L
G
T
L
D
R
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
49
HHSearch
59.33
38%
-45
- C2 -
5ERB
-
?
A:
[6-532]
-------------------------------------------------------------------------------------------------------------------
R
E
D
I
A
I
I
G
I
S
G
R
Y
P
Q
A
-
E
N
L
Q
E
F
W
K
N
L
S
E
G
T
D
C
I
T
E
I
P
N
D
R
W
--
D
H
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L
Y
Y
-
D
A
D
K
D
K
E
G
K
T
Y
G
K
W
G
G
F
L
K
D
V
D
K
F
D
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F
F
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R
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A
K
L
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D
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Q
E
R
L
F
L
Q
C
V
Y
E
T
M
E
D
A
G
Y
T
R
K
K
L
T
E
K
SGDL
L
G
A
N
V
G
V
Y
V
G
V
M
Y
E
E
Y
Q
L
Y
G
A
E
E
Q
----
A
-
R
--------
T
G
N
P
S
S
I
A
N
R
A
S
Y
V
F
G
F
N
G
P
S
M
A
L
D
T
M
C
S
S
S
L
T
A
I
H
L
A
C
Q
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L
R
N
G
E
C
E
A
A
F
A
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G
V
N
V
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V
H
P
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Y
L
M
L
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Q
N
-
R
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G
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G
G
D
G
Y
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G
A
V
L
L
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L
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A
K
A
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G
D
H
I
Y
G
L
I
K
G
T
A
V
N
H
D
G
-
K
-
T
-
N
G
Y
S
V
P
N
P
N
A
Q
A
A
V
I
K
Q
A
L
K
D
A
G
T
D
P
R
A
V
S
Y
I
E
A
H
G
T
G
T
S
L
G
D
P
I
E
I
T
G
L
T
K
A
F
S
E
Q
T
Q
---------
Q
F
C
A
I
G
S
A
K
S
N
I
G
H
C
E
S
A
A
G
I
A
G
L
T
K
V
L
L
Q
M
K
H
K
Q
L
A
P
S
L
H
S
R
T
L
N
P
N
I
D
-
F
L
A
T
P
F
K
V
Q
Q
T
L
E
E
W
K
-
R
P
V
INEN--
L
P
R
T
A
G
L
S
S
F
G
A
G
G
V
N
A
H
I
V
I
E
E
Y
S
------------------------------------------------------------------------------
P
H
P
S
M
I
V
L
S
A
K
N
E
Q
R
L
Q
K
R
A
K
R
L
L
D
A
L
-----
R
S
G
R
--
Y
-----
R
E
A
D
L
S
R
I
A
Y
T
L
-
Q
V
G
R
E
P
M
-
E
E
R
L
G
M
I
V
S
N
L
R
E
L
E
E
K
L
D
E
F
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------