@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3910: (2016-05-24 )
MRPSPGEVPTASQRQPELSDAALVSHSWAMAFATLISRITGFARIVLLAAILGAALASSFSVANQLPNLVAALVLEATFTAIFVPVLARAEQDDPDGGAAFVRRLVTLATTLLLGATTLSVLAAPLLVRLMLGTNPQVNEPLTTAFAYLLLPQVLVYGLSSVFMAILNTRNVFGPPAWAPVVNNVVAIATLAVYLAVPGELSVDPVRMGNAKLLVLGIGTTAGVFAQTAVLLVAIRREHISLRPLWGIDQRLKRFGAMAAAMVLYVLISQLGLVVGNRIASTAAASGPAIYNYTWLVLMLPFGMIGVTVLTVVMPRLSRNAAADDTPAVLADLSLATRLTMITLIPTVAFMTVGGPAIGSALFAYGNFGDVDAGYLGAAIALSAFTLIPYALVLLQLRVFYAREQPWTPITIIVVITGVKILGSLLAPHITGDPQLVAAYLGLANGLGFLAGTIVGYYILRRALRPDGGQLIGVGEARTVLVTVAASLLAGLLAHVADRLLGLSELTAHAGSVGSLLRLSVLALIMLPILAAVTLCARVPEARAALDAVRARIRSRRLKTGPQTQNVLDQSSRPGPVTYPERRRLAPPRGKSVVHEPIRRRPPEQVARAGRAKGPEVIDRPSENASFGAASGAELPRPVADELQLDAPAGRDPGPVSRPHPSDLQNGDLPADAARGPIAFDALREPDRESSAPPDDVQLVPGARIANGRYRLLIFHGGVPPLQFWQALDTALDRQVALTFVDPQGVLPDDVLQETLSRTLRLSRIDKPGVARVLDVVHTRAGGLVVAEWIRGGSLQEVADTSPSPVGAIRAMQSLAAAADAAHRAGVALSIDHPSRVRVSIDGDVVLAYPATMPDANPQDDIRGIGASLYALLVNRWPLPEAGVRSGLAPAERDTAGQPIEPADIDRDIPFQISAVAARSVQGDGGIRSASTLLNLMQQATAVADRTEVLGPIDEAPVSAAPRTSAPNSETYTRRRRNLLIGIGAGAAVLMVALLVLASVLSRIFGDVSGGLNKDELGLNAPTASTSAASSAPPGSVVKPTKVTVFSPDGGADNPGEADLAIDGNPATSWKTDIYTDPVPFPSFKNGVGLMLQLPQATVVGTVAIDVASTGTKVEIRSASTPTPATLEDTAVLTSATALRPGHNTISVEAAAPTSNLLVWISTLGTTDGKSQADISEITIYAAS
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470.......480.......490.......500.......510.......520.......530.......540.......550.......560.......570.......580.......590.......600.......610.......620.......630.......640.......650.......660.......670.......680.......690.......700.......710.......720.......730.......740......---.750.......760.......770.......780.......790.......800-------.--........810-.......820.......830.......840---.----......850.------------------------------.--------.....860.......870.......880.......890....---...900.......910.......920......-.930.......940.......950.......960.......970.......980.......990.......1000......1010......1020......1030......1040......1050......1060......1070......1080......1090......1100......1110......1120......1130......1140......1150......1160......1170......1180.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRPSPGEVPTASQRQPELS
D
A
A
L
V
S
H
S
W
A
M
A
F
A
T
L
I
S
R
I
T
G
F
A
R
I
V
L
L
A
A
I
L
G
A
A
L
A
S
S
F
S
V
A
N
Q
L
P
N
L
V
A
A
L
V
L
E
A
T
F
T
A
I
F
V
P
V
L
A
RAEQDDPD
G
G
A
A
F
V
R
R
L
V
T
L
A
T
T
L
L
L
G
A
T
T
L
S
V
L
A
A
P
L
L
V
R
L
MLGTNPQVNE
P
L
T
T
A
F
A
Y
L
L
L
P
Q
V
L
V
Y
G
L
S
S
V
F
M
A
I
LNTRNVFGPP
A
W
A
P
V
V
N
N
V
V
A
I
A
T
L
A
V
Y
L
AVPGELSVD
P
V
RMGN
A
K
L
L
V
L
GIGT
T
A
G
V
F
A
Q
T
A
V
L
L
V
A
I
R
R
E
HISLRPLW
G
I
D
Q
R
L
K
R
F
G
A
M
A
A
A
M
V
L
Y
V
L
I
S
Q
L
G
L
V
VGNRIASTAAASG
P
A
I
Y
N
Y
T
W
L
V
L
M
L
P
F
G
M
I
G
V
T
V
L
T
V
V
M
P
R
LSRNAAADD
T
P
A
V
L
A
D
L
S
L
A
T
R
L
T
M
I
T
L
IP
T
V
A
F
M
TVG
G
P
A
I
G
S
A
L
F
AYGNFGDV
D
A
G
Y
L
G
A
A
I
A
L
S
A
F
T
L
I
P
Y
A
L
V
L
L
Q
L
R
V
F
YAREQPWT
P
I
T
I
I
V
V
I
T
G
V
K
I
L
G
S
L
L
A
PHITG
D
P
Q
L
V
A
A
Y
L
G
L
AN
G
L
G
F
L
A
G
T
I
V
G
Y
Y
I
L
R
R
A
LRPDG
G
Q
L
I
GVGEAR
T
V
L
V
T
V
A
A
S
L
L
A
G
L
L
A
H
V
A
D
R
L
L
G
L
S
E
L
T
A
HA
G
S
V
G
S
L
L
R
L
S
V
L
A
L
I
M
L
P
I
L
A
A
V
T
L
C
ARV
P
E
A
R
A
A
L
D
A
V
R
A
R
I
R
S
R
RLKTGPQ
T
Q
N
V
L
DQSSRPGPVT
Y
P
E
RRRLAPPRG
K
S
V
V
H
E
P
I
RRR
P
P
E
Q
V
A
R
AGRAKGPEVIDRPSENASFGAASGAELPRP
V
A
D
E
LQLDAPAGRDPGPVSRPHPSDLQNGDLPADAARGPI
A
F
D
A
LREPDRESSAPPDD
V
Q
LVPG
A
R
IANG
R
Y
R
L
L
I
F
HGGV
P
P
L
Q
F
W
Q
A
L
D
T
A
LDR
Q
V
A
L
T
F
VDPQGVL
P
---
D
D
V
L
Q
E
T
L
S
R
T
L
R
L
SRIDKP
G
V
A
R
V
L
D
V
V
HTRAGG
L
V
V
A
E
W
IRGG
S
L
Q
E
V
AD---------T--SPS
P
V
G
A
I
R
A
M
-
Q
S
L
A
A
A
A
D
A
A
HRA
G
V
A
L
SIDHP
S
R
V
R
V
S
ID---G----
D
V
V
L
A
YPATM------------------------------P--------DAN
P
Q
D
D
I
R
G
I
G
A
S
L
Y
A
L
L
V
NRWPL
P
E
A
G
V
RSGLAPAERDTA---GQPI
E
P
A
DIDRDIP
F
Q
I
S
A
V
A
A
RSVQGDGGI
R
-
S
A
S
T
L
L
N
L
M
Q
Q
A
T
A
VA
D
R
T
E
VLGPIDEAPVSAAPRTSAPNS
E
T
Y
T
R
RRR
N
L
L
I
G
IG
A
G
A
A
V
L
M
V
A
L
L
V
L
A
S
V
L
S
R
I
F
G
D
VSGGL
N
K
D
E
LGLNAPTASTSAASSAPPGSVVK
P
T
K
V
T
V
FSPDGGADNPGEA
D
L
A
IDGNPATSWKTDIYTDPVPFPSFKNG
V
G
L
M
L
QLPQ
A
T
V
V
G
T
V
A
I
D
VASTG
T
K
V
E
I
RSASTPTPATLED
T
A
V
L
T
S
A
T
ALRPGH
N
T
I
S
V
E
AAAPTS
N
L
L
V
W
I
S
TLGTTDGKSQADI
S
E
I
T
I
Y
AAS
1
PsiBlast_PDB
97.36
99%
-84
- C4 -
3OUN
1
B:
[23-279]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
V
P
G
A
R
I
A
N
G
R
Y
R
L
L
I
F
H
G
G
V
P
P
L
Q
F
W
Q
A
L
D
T
A
L
D
R
Q
V
A
L
T
F
V
D
P
Q
G
V
L
P
---
D
D
V
L
Q
E
T
L
S
R
T
L
R
L
S
R
I
D
K
P
G
V
A
R
V
L
D
V
V
H
T
R
A
G
G
L
V
V
A
E
W
I
R
G
G
S
L
Q
E
V
A
D
---------
T
--
S
P
S
P
V
G
A
I
R
A
M
-
Q
S
L
A
A
A
A
D
A
A
H
R
A
G
V
A
L
S
I
D
H
P
S
R
V
R
V
S
I
D
---
G
----
D
V
V
L
A
Y
P
A
T
M
------------------------------
P
--------
D
A
N
P
Q
D
D
I
R
G
I
G
A
S
L
Y
A
L
L
V
N
R
W
P
L
P
E
A
G
V
R
S
G
L
A
P
A
E
R
D
T
A
---
G
Q
P
I
E
P
A
D
I
D
R
D
I
P
F
Q
I
S
A
V
A
A
R
S
V
Q
G
D
G
G
I
R
-
S
A
S
T
L
L
N
L
M
Q
Q
A
T
A
V
A
D
R
T
E
V
L
G
P
I
D
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_CBE
96.72
100%
-84
- C4 -
3UQC
1
MVIN_MYCTU
B:
[22-265]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
V
P
G
A
R
I
A
N
G
R
Y
R
L
L
I
F
H
G
G
V
P
P
L
Q
F
W
Q
A
L
D
T
A
L
D
R
Q
V
A
L
T
F
V
D
P
Q
G
V
L
P
---
D
D
V
L
Q
E
T
L
S
R
T
L
R
L
S
R
I
D
K
P
G
V
A
R
V
L
D
V
V
H
T
R
A
G
G
L
V
V
A
E
W
I
R
G
G
S
L
Q
E
V
A
D
---------
T
--
S
P
S
P
V
G
A
I
R
A
M
-
Q
S
L
A
A
A
A
D
A
A
H
R
A
G
V
A
L
S
I
D
H
P
S
R
V
R
V
S
I
D
---
G
----
D
V
V
L
A
Y
P
A
T
M
------------------------------
P
--------
D
A
N
P
Q
D
D
I
R
G
I
G
A
S
L
Y
A
L
L
V
N
R
W
P
L
P
E
A
G
V
R
S
G
L
A
P
A
E
R
D
T
A
---
G
Q
P
I
E
P
A
D
I
D
R
D
I
P
F
Q
I
S
A
V
A
A
R
S
V
Q
G
D
G
G
I
R
-
S
A
S
T
L
L
N
L
M
Q
Q
A
T
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
Fugue
96.46
100%
-85
- C4 -
3UQC
-
MVIN_MYCTU
A:
[20-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
L
V
P
G
A
R
I
A
N
G
R
Y
R
L
L
I
F
H
G
G
V
P
P
L
Q
F
W
Q
A
L
D
T
A
L
D
R
Q
V
A
L
T
F
V
D
P
Q
G
V
L
P
---
D
D
V
L
Q
E
T
L
S
R
T
L
R
L
S
R
I
D
K
P
G
V
A
R
V
L
D
V
V
H
T
R
A
G
G
L
V
V
A
E
W
I
R
G
G
S
L
Q
E
V
A
D
---------
T
--
S
P
S
P
V
G
A
I
R
A
M
-
Q
S
L
A
A
A
A
D
A
A
H
R
A
G
V
A
L
S
I
D
H
P
S
R
V
R
V
S
I
D
---
G
----
D
V
V
L
A
Y
P
A
T
M
------------------------------
P
--------
D
A
N
P
Q
D
D
I
R
G
I
G
A
S
L
Y
A
L
L
V
N
R
W
P
L
P
E
A
G
V
R
S
G
L
A
P
A
E
R
D
T
A
---
G
Q
P
I
E
P
A
D
I
D
R
D
I
P
F
Q
I
S
A
V
A
A
R
S
V
Q
G
D
G
G
I
R
-
S
A
S
T
L
L
N
L
M
Q
Q
A
T
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
96.46
100%
-85
- C4 -
3UQC
-
MVIN_MYCTU
A:
[20-265]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
L
V
P
G
A
R
I
A
N
G
R
Y
R
L
L
I
F
H
G
G
V
P
P
L
Q
F
W
Q
A
L
D
T
A
L
D
R
Q
V
A
L
T
F
V
D
P
Q
G
V
L
P
---
D
D
V
L
Q
E
T
L
S
R
T
L
R
L
S
R
I
D
K
P
G
V
A
R
V
L
D
V
V
H
T
R
A
G
G
L
V
V
A
E
W
I
R
G
G
S
L
Q
E
V
A
D
---------
T
--
S
P
S
P
V
G
A
I
R
A
M
-
Q
S
L
A
A
A
A
D
A
A
H
R
A
G
V
A
L
S
I
D
H
P
S
R
V
R
V
S
I
D
---
G
----
D
V
V
L
A
Y
P
A
T
M
------------------------------
P
--------
D
A
N
P
Q
D
D
I
R
G
I
G
A
S
L
Y
A
L
L
V
N
R
W
P
L
P
E
A
G
V
R
S
G
L
A
P
A
E
R
D
T
A
---
G
Q
P
I
E
P
A
D
I
D
R
D
I
P
F
Q
I
S
A
V
A
A
R
S
V
Q
G
D
G
G
I
R
-
S
A
S
T
L
L
N
L
M
Q
Q
A
T
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
96.37
100%
-83
- C4 -
3OTV
-
MVIN_MYCTU
A:
[16-269]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
Q
L
V
P
G
A
R
I
A
N
G
R
Y
R
L
L
I
F
H
G
G
V
P
P
L
Q
F
W
Q
A
L
D
T
A
L
D
R
Q
V
A
L
T
F
V
D
P
Q
G
V
L
P
---
D
D
V
L
Q
E
T
L
S
R
T
L
R
L
S
R
I
D
K
P
G
V
A
R
V
L
D
V
V
H
T
R
A
G
G
L
V
V
A
E
W
I
R
G
G
S
L
Q
E
V
A
D
---------
T
--
S
P
S
P
V
G
A
I
R
A
M
-
Q
S
L
A
A
A
A
D
A
A
H
R
A
G
V
A
L
S
I
D
H
P
S
R
V
R
V
S
I
D
---
G
----
D
V
V
L
A
Y
P
A
T
M
------------------------------
P
--------
D
A
N
P
Q
D
D
I
R
G
I
G
A
S
L
Y
A
L
L
V
N
R
W
P
L
P
E
A
G
V
R
S
G
L
A
P
A
E
R
D
T
A
---
G
Q
P
I
E
P
A
D
I
D
R
D
I
P
F
Q
I
S
A
V
A
A
R
S
V
Q
G
D
G
G
I
R
-
S
A
S
T
L
L
N
L
M
Q
Q
A
T
A
V
A
D
R
T
E
V
L
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
95.45
100%
-85
- C4 -
3OUK
-
A:
[17-264]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
V
P
G
A
R
I
A
N
G
R
Y
R
L
L
I
F
H
G
G
V
P
P
L
Q
F
W
Q
A
L
D
T
A
L
D
R
Q
V
A
L
T
F
V
D
P
Q
G
V
L
P
---
D
D
V
L
Q
E
T
L
S
R
T
L
R
L
S
R
I
D
K
P
G
V
A
R
V
L
D
V
V
H
T
R
A
G
G
L
V
V
A
E
W
I
R
G
G
S
L
Q
E
V
A
D
---------
T
--
S
P
S
P
V
G
A
I
R
A
M
-
Q
S
L
A
A
A
A
D
A
A
H
R
A
G
V
A
L
S
I
D
H
P
S
R
V
R
V
S
I
D
---
G
----
D
V
V
L
A
Y
P
A
T
M
------------------------------
P
--------
D
A
N
P
Q
D
D
I
R
G
I
G
A
S
L
Y
A
L
L
V
N
R
W
P
L
P
E
A
G
V
R
S
G
L
A
P
A
E
R
D
T
A
---
G
Q
P
I
E
P
A
D
I
D
R
D
I
P
F
Q
I
S
A
V
A
A
R
S
V
Q
G
D
G
G
I
R
-
S
A
S
T
L
L
N
L
M
Q
Q
A
T
A
V
A
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
93.73
96%
-81
- C4 -
3UQC
-
MVIN_MYCTU
A:
[21-265]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
L
V
P
G
A
R
I
A
N
G
R
Y
R
L
L
I
F
H
G
G
V
P
P
L
Q
F
W
Q
A
L
D
T
A
L
D
R
Q
V
A
L
T
F
V
D
P
Q
G
V
L
P
---
D
D
V
L
Q
E
T
L
S
R
T
L
R
L
S
R
I
D
K
P
G
V
A
R
V
L
D
V
V
H
T
R
A
G
G
L
V
V
A
E
W
I
R
G
G
S
L
Q
E
V
A
D
---------
T
--
S
-
P
S
P
V
G
A
I
R
A
M
Q
S
L
A
A
A
A
D
A
A
H
R
A
G
V
A
L
S
I
D
H
P
S
R
V
R
V
S
I
D
---
G
----
D
V
V
L
A
Y
P
A
T
M
------------------------------
P
--------
D
A
N
P
Q
D
D
I
R
G
I
G
A
S
L
Y
A
L
L
V
N
R
W
P
L
P
E
A
G
V
R
S
G
L
A
P
A
E
R
D
T
A
---
G
Q
P
I
E
P
A
D
I
D
R
D
I
P
F
Q
I
S
A
V
A
A
R
S
V
Q
G
D
G
G
I
R
-
S
A
S
T
L
L
N
L
M
Q
Q
A
T
A
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
HHSearch
58.88
17%
-39
- C4 -
5D9H
3
STK39_MOUSE
A:
[11-291]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
W
P
I
C
R
D
A
Y
E
L
Q
E
V
I
G
S
G
A
T
A
V
V
Q
A
A
L
C
K
P
R
Q
E
R
V
A
I
K
R
I
N
L
E
K
C
Q
-----
T
S
M
D
E
L
L
K
E
I
Q
A
M
S
Q
C
S
H
P
N
V
V
T
Y
Y
T
S
F
V
V
K
D
E
L
W
L
V
M
K
L
L
S
G
G
S
M
L
D
I
I
K
Y
I
V
N
R
GEHK
N
--
G
V
L
E
E
A
I
I
A
T
I
L
K
E
V
L
E
G
L
D
Y
L
H
R
N
G
Q
I
H
R
D
L
K
A
G
N
I
L
L
G
E
D
---
G
----
S
V
Q
I
A
D
F
G
V
S
A
F
L
A
TGGDVTRVGTPCWMA
P
E
V
M
E
Q
V
----
R
--------
G
Y
D
F
K
A
D
M
W
S
F
G
I
T
A
I
E
L
A
T
G
A
A
P
Y
H
K
Y
P
P
M
K
V
L
M
L
T
L
Q
N
D
P
PTL
E
T
G
V
--
K
E
M
M
K
K
Y
G
K
S
F
R
K
L
L
S
L
C
L
Q
K
D
P
S
K
R
P
T
A
A
E
L
L
K
C
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
27
HHSearch
57.83
12%
-40
- C4 -
3TKI
2
CHK1_HUMAN
A:
[4-261]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
F
V
E
D
W
D
L
V
Q
T
L
G
E
G
A
Y
G
E
V
Q
L
A
V
N
R
V
T
E
E
A
V
A
V
K
I
V
D
M
K
------------
N
I
K
K
E
I
C
I
N
K
M
L
N
H
E
N
V
V
K
F
Y
G
H
R
R
E
G
N
I
Q
Y
L
F
L
E
Y
C
S
G
G
E
L
F
D
R
I
E
---------
P
D-
I
G
M
P
E
P
D
A
Q
R
F
F
H
Q
L
M
A
G
V
V
Y
L
H
G
I
G
I
T
H
R
D
I
K
P
E
N
L
L
L
D
E
R
---
D
----
N
L
K
I
S
D
F
G
L
A
TVFRYNN
R
E
R
L
L
N
K
MCGTLPYVA
P
E
L
L
K
RR
E
--------
F
H
A
E
P
V
D
V
W
S
C
G
I
V
L
T
A
M
L
A
G
E
L
P
W
D
Q
P
S
D
S
C
Q
E
-
Y
S
D
W
K
E
K
---
K
T
Y
L
N
---
P
W
K
K
I
D
S
A
P
L
A
L
L
H
K
I
L
V
E
N
P
S
A
R
I
T
I
P
D
I
K
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
36
HHSearch
57.72
17%
-38
- C4 -
3FE3
-
MARK3_HUMAN
A:
[53-303]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
I
G
N
Y
R
L
L
K
T
I
G
K
G
N
F
A
K
V
K
L
A
R
H
I
L
T
G
R
E
V
A
I
K
I
I
D
K
T
Q
L
N
P
----
T
S
L
Q
K
L
F
R
E
V
R
I
M
K
I
L
N
H
P
N
I
V
K
L
F
E
V
I
E
T
E
K
T
L
Y
L
I
M
E
Y
A
S
G
G
E
V
F
D
Y
L
V
A
--------
H
--
G
R
M
K
E
K
E
A
R
S
K
F
R
Q
I
V
S
A
V
Q
Y
C
H
Q
K
R
I
V
H
R
D
L
K
A
E
N
L
L
L
D
A
D
---
M
----
N
I
K
I
A
D
F
G
F
S
NEFTVGGKLDAFCGAPPYA-----------
A
PELFQGKK
Y
D
G
P
E
V
D
V
W
S
L
G
V
I
L
Y
T
L
V
S
G
S
L
P
F
D
G
Q
N
L
K
E
-
L
R
E
R
V
--
L
R
---
G
K
Y
----
R
I
P
F
Y
M
S
T
D
C
E
N
L
L
K
R
F
L
V
L
N
P
I
K
R
G
T
L
E
Q
I
M
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
23
HHSearch
56.97
21%
-24
- C4 -
4ZHX
2
?
A:
[23-410]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
K
I
G
H
Y
V
L
G
D
T
L
G
V
G
T
F
G
K
V
K
I
G
E
H
Q
L
T
G
H
K
V
A
V
K
I
L
N
R
Q
K
I
R
S
---
L
D
V
V
G
K
I
K
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
T
D
F
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
---------
K
H
-
G
R
V
E
E
M
E
A
R
R
L
F
Q
Q
I
L
S
A
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
---
M
----
N
A
K
I
A
D
F
G
L
S
N
M
M
S
D
GEFLRTSCGSPNYA
A
P
E
V
I
SGR---
L
--------
Y
A
G
P
E
V
D
I
W
S
C
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
E
H
V
P
T
-
L
F
K
K
I
--
R
G
---
G
V
F
----
Y
I
P
E
Y
L
N
R
S
V
A
T
L
L
M
H
M
L
Q
V
D
P
L
K
R
A
T
I
K
D
I
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
30
HHSearch
56.57
13%
-27
- C4 -
1KOB
1
?
A:
[50-304]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
D
Y
Y
D
I
L
E
E
L
G
S
G
A
F
G
V
V
H
R
C
V
E
K
A
T
G
R
V
F
V
A
K
F
I
N
T
P
Y
P
L
------
D
K
Y
T
V
K
N
E
I
S
I
M
N
Q
L
H
H
P
K
L
I
N
L
H
D
A
F
E
D
K
Y
E
M
V
L
I
L
E
F
L
S
G
G
E
L
F
D
R
I
A
---------
A
ED
Y
K
M
S
E
A
E
V
I
N
Y
M
R
Q
A
C
E
G
L
K
H
M
H
E
H
S
I
V
H
L
D
I
K
P
E
N
I
M
C
E
T
K
KA-
S
----
S
V
K
I
I
D
F
G
L
A
TKLNPD
E
I
V
K
V
T
TATAEFAA
P
E
I
V
D
R----
E
--------
P
V
G
F
Y
T
D
M
W
A
I
G
V
L
G
Y
V
L
L
S
G
L
S
P
F
A
G
E
D
D
L
E
T
L
---
Q
N
V
K
R
---
C
D
W
E
F
D
E
D
A
F
S
S
V
S
P
E
A
K
D
F
I
K
N
L
L
Q
K
E
P
R
K
R
L
T
V
H
D
A
L
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
22
HHSearch
55.92
18%
-38
- C4 -
4CZU
7
CIPKN_ARATH
A:
[7-269]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
T
R
V
G
K
Y
E
L
G
R
T
L
G
E
G
T
F
A
K
V
K
F
A
R
N
V
E
N
G
D
N
V
A
I
K
V
I
D
K
E
K
V
L
K
---
N
K
M
I
A
Q
I
K
R
E
I
S
T
M
K
L
I
K
H
P
N
V
I
R
M
F
E
V
M
A
S
K
T
K
I
Y
F
V
L
E
F
V
T
G
G
E
L
F
D
K
I
S
---------
S
N-
G
R
L
K
E
D
E
A
R
K
Y
F
Q
Q
L
I
N
A
V
D
Y
C
H
S
R
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
A
N
---
G
----
A
L
K
V
S
D
F
G
L
S
ALPQQVREDGLLHDTCGTPNYVA
P
E
V
I
N
NK
G
--------
Y
D
G
A
K
A
D
L
W
S
C
G
V
I
L
F
V
L
M
A
G
Y
L
P
F
E
D
S
N
L
T
S
-
L
Y
K
K
I
F
--
K
---
A
E
F
----
T
C
P
P
W
F
S
A
S
A
K
K
L
I
K
R
I
L
D
P
N
P
A
T
R
I
T
F
A
E
V
I
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
55.51
20%
-33
- C4 -
4RED
-
AAPK1_HUMAN
A:
[13-266]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
I
G
H
Y
I
L
G
D
T
L
G
V
G
T
F
G
K
V
K
V
G
K
H
E
L
T
G
H
A
V
A
V
K
I
L
N
R
Q
K
I
R
S
---
L
D
V
V
G
K
I
R
R
E
I
Q
N
L
K
L
F
R
H
P
H
I
I
K
L
Y
Q
V
I
S
T
P
S
D
I
F
M
V
M
E
Y
V
S
G
G
E
L
F
D
Y
I
C
---------
K
N-
G
R
L
D
E
K
E
S
R
R
L
F
Q
Q
I
L
S
G
V
D
Y
C
H
R
H
M
V
V
H
R
D
L
K
P
E
N
V
L
L
D
A
H
---
M
----
N
A
K
I
A
D
F
G
L
S
NMMSDS
P
N
Y
A
A
P
E
V
I
S
GR------------
L
--------
Y
A
G
P
E
V
D
I
W
S
S
G
V
I
L
Y
A
L
L
C
G
T
L
P
F
D
D
D
H
V
P
T
-
L
F
--
K
K
-------
I
F
Y
T
----
P
Q
Y
L
N
P
S
V
I
S
L
L
K
H
M
L
Q
V
D
P
M
K
R
A
S
I
K
D
I
R
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
33
HHSearch
54.86
17%
-40
- C4 -
4D28
-
CIPKO_ARATH
A:
[8-260]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
G
K
Y
E
V
G
R
T
I
-----
A
K
V
K
F
A
R
N
T
D
T
G
D
N
V
A
I
K
I
M
A
K
S
T
I
L
K
---
N
R
M
V
D
Q
I
K
R
E
I
S
I
M
K
I
V
R
H
P
N
I
V
R
L
Y
E
V
L
A
S
K
S
K
I
Y
I
V
L
E
F
V
T
G
G
E
L
F
D
R
I
V
H
--------
K
--
G
R
L
K
E
D
E
S
R
K
Y
F
Q
Q
L
V
D
A
V
A
H
C
H
S
K
G
V
Y
H
R
D
L
K
P
E
N
L
L
L
D
T
N
---
G
----
N
L
K
V
S
D
F
G
L
S
ALPQEGLNDTCGTPNYVA
P
E
V
L
S
GQ-----
G
--------
Y
D
G
S
A
A
D
I
W
S
C
G
V
I
L
F
V
I
L
A
G
Y
L
P
F
S
E
T
D
L
P
G
-
L
Y
R
K
I
--
N
A
---
A
E
F
----
D
C
P
P
W
F
S
A
E
V
K
F
L
I
H
R
I
L
D
P
N
P
K
T
R
I
Q
I
Q
G
I
K
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
25
HHSearch
53.74
16%
-34
- C4 -
4FIE
1
PAK4_HUMAN
A:
[151-400]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
------
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
---------
H
--
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
----
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
KEVPRRKSLVGTPYWM
A
P
E
L
I
SR---
L
--------
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
---
M
I
R
D
---
N
L
P
P
R
L
-
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
HHSearch
53.62
13%
-27
* C4 *
2YAB
5
DAPK2_MOUSE
A:
[9-272]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
E
D
F
Y
D
I
G
E
E
L
G
S
G
Q
F
A
I
V
K
K
C
R
E
K
S
T
G
L
E
Y
A
A
K
F
I
K
K
R
Q
S
R
A
SRR
G
V
C
R
E
E
I
E
R
E
V
S
I
L
R
Q
V
L
H
P
N
I
I
T
L
H
D
V
Y
E
N
R
T
D
V
V
L
I
L
E
L
V
S
G
G
E
L
F
D
F
L
A
---------
Q
K-
E
S
L
S
E
E
E
A
T
S
F
I
K
Q
I
L
D
G
V
N
Y
L
H
T
K
K
I
A
H
F
D
L
K
P
E
N
I
M
L
L
D
K
---
N
IP
I
P
H
I
K
L
I
D
F
G
L
A
H
E
I
E
D
G
V
E
F
K
N
I
F
G
T
PEFVA
P
E
I
V
N
Y----
E
--------
P
L
G
L
E
A
D
M
W
S
I
G
V
I
T
Y
I
L
L
S
G
A
S
P
F
L
G
D
T
K
Q
E
T
L
A
-
N
I
T
A
V
-----
S
Y
D
F
D
E
E
F
F
S
Q
T
S
E
L
A
K
D
F
I
R
K
L
L
V
K
E
T
R
K
R
L
T
I
Q
E
A
L
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
35
HHSearch
53.33
16%
-36
- C4 -
3SOA
1
KCC2A_HUMAN
A:
[8-267]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
F
T
E
E
Y
Q
L
F
E
E
L
G
K
G
--
S
V
V
R
R
C
V
K
V
L
A
G
Q
E
Y
A
A
M
I
I
N
T
K
K
L
S
A
----
R
D
H
Q
K
L
E
R
E
A
R
I
C
R
L
L
K
H
P
N
I
V
R
L
H
D
S
I
S
E
E
G
H
H
Y
L
I
F
D
L
V
T
G
G
E
L
F
E
D
I
V
A
--------
R
--
E
Y
Y
S
E
A
D
A
S
H
C
I
Q
Q
I
L
E
A
V
L
H
C
H
Q
M
G
V
V
H
R
N
L
K
P
E
N
L
L
L
A
S
K
LKG
A
----
A
V
K
L
A
D
F
G
L
A
I
E
V
E
GE
Q
Q
A
W
FGFAGTPGYLS
P
E
V
L
R
K---
D
--------
P
Y
G
K
P
V
D
L
W
A
C
G
V
I
L
Y
I
L
L
V
G
Y
P
P
F
W
D
E
D
Q
H
R
-
L
Y
Q
Q
I
K
--
A
---
G
A
Y
D
F
P
S
P
E
W
D
T
V
T
P
E
A
K
D
L
I
N
K
M
L
T
I
N
P
S
K
R
I
T
A
A
E
A
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
40
HHSearch
51.83
15%
-32
- C4 -
4LGD
3
STK3_HUMAN
A:
[26-284]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
V
F
D
V
L
E
K
L
G
E
G
S
Y
G
S
V
F
K
A
I
H
K
E
S
G
Q
V
V
A
I
K
Q
V
P
V
E
S
--------
D
L
Q
E
I
I
K
E
I
S
I
M
Q
Q
C
D
S
P
Y
V
V
K
Y
Y
G
S
Y
F
K
N
T
D
L
W
I
V
M
E
Y
C
G
A
G
S
V
S
D
I
I
R
---------
L
R
N
K
T
L
I
E
D
E
I
A
T
I
L
K
S
T
L
K
G
L
E
Y
L
H
F
M
R
K
I
H
R
N
I
K
A
G
N
I
L
L
N
T
E
---
G
----
H
A
K
L
A
D
F
G
V
A
GQLTDTMAKRN
T
V
I
G
T
PFWMA
P
E
V
I
Q
E
---
I
--------
G
Y
N
C
V
A
D
I
W
S
L
G
I
T
S
I
E
M
A
E
G
K
P
P
Y
A
D
I
H
P
M
R
A
I
F
M
-
I
--
P
T
----
N
P
P
P
T
F
R
K
P
E
L
W
S
D
D
F
T
D
F
V
K
K
C
L
V
K
N
P
E
Q
R
A
T
A
T
Q
L
L
Q
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
37
HHSearch
50.66
15%
-25
- C4 -
4XBR
3
F212A_HUMAN (first)
A:
[94-343]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
Y
L
D
N
F
I
K
I
G
E
G
S
T
G
I
V
C
I
A
T
V
R
S
S
G
K
L
V
A
V
K
K
M
D
L
R
K
Q
------
Q
R
R
E
L
L
F
N
E
V
V
I
M
R
D
Y
Q
H
E
N
V
V
E
M
Y
N
S
Y
L
V
G
D
E
L
W
V
V
M
E
F
L
E
G
G
A
L
T
D
I
V
T
---------
H
--
T
R
M
N
E
E
Q
I
A
A
V
C
L
A
V
L
Q
A
L
S
V
L
H
A
Q
G
V
I
H
R
D
I
K
S
D
S
I
L
L
T
H
D
---
G
----
R
V
K
L
S
D
F
G
F
C
A
Q
V
S
KEVPRRKSLVGTPYWM
A
P
E
L
I
SR---
L
--------
P
Y
G
P
E
V
D
I
W
S
L
G
I
M
V
I
E
M
V
D
G
E
P
P
Y
F
N
E
P
P
L
K
A
M
K
-
M
I
--
R
D
----
N
L
P
P
R
L
K
N
L
H
K
V
S
P
S
L
K
G
F
L
D
R
L
L
V
R
D
P
A
Q
R
A
T
A
A
E
L
L
K
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------