@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : Rv3913: (2016-05-24 )
MTAPPVHDRAHHPVRDVIVIGSGPAGYTAALYAARAQLAPLVFEGTSFGGALMTTTDVENYPGFRNGITGPELMDEMREQALRFGADLRMEDVESVSLHGPLKSVVTADGQTHRARAVILAMGAAARYLQVPGEQELLGRGVSSCATCDGFFFRDQDIAVIGGGDSAMEEATFLTRFARSVTLVHRRDEFRASKIMLDRARNNDKIRFLTNHTVVAVDGDTTVTGLRVRDTNTGAETTLPVTGVFVAIGHEPRSGLVREAIDVDPDGYVLVQGRTTSTSLPGVFAAGDLVDRTYRQAVTAAGSGCAAAIDAERWLAEHAATGEADSTDALIGAQR
Atome Classification :
(49 SA)
.........10.....-...20........30........40....-----.-----.-----..50..-----......60........70........80......---..90.....---.-------..100----..--....---..110.......120.......130....----...----140.......150.--........160.......170.......180.......190...---....200---.......210...---...-.220--..----.-......230.-.......240.......250......-.260.......270----..----.....280.......290.--......300.......310.....-..320.......330...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MTAPPVHDRAHHPV
R
D
-
V
I
V
IGSGPA
G
Y
T
A
A
L
Y
A
A
R
A
QL
A
P
L
V
FEG-----T-----S-----FG
G
A
L
M
-----
T
TTDVENYPGFRNGIT
G
P
E
L
M
D
E
M
R
E
Q
A
L
RFGAD---LRMEDVESV---S-------LHG-P----
L
K
--
S
V
VT---ADGQT
H
R
A
R
A
V
I
L
AMGAA
A
R
Y
LQVP
G
E
Q
E
----
L
L
G
----
R
G
V
S
S
CATCDG--
F
--
F
F
RDQ
D
I
A
V
IGGG
D
S
A
M
E
E
A
T
F
L
T
R
F
A
R
S
V
T
L
V
H
R
R
D
EF
R
A
S
K
I
---
M
L
DRARN---N
D
K
I
R
F
LTN
H
T
V
V
---
A
VD-GD----
T
T
----
V
-
T
G
L
R
V
RDT-N-TGA
E
T
T
L
P
V
T
G
V
F
V
A
IGHEPRS
G
L
V
R
-
E
AIDVDPD
G
Y
V
L
V
Q----GR----TTSTSLPG
V
F
A
A
G
D
L
V
D
R
T
--
Y
R
Q
A
V
TAAGSGCA
A
A
I
D
A
E
R
W
L
A
E
-HAATGEADSTDALIGAQR
71
HHSearch
97.01
100%
-119
- C1 -
2A87
5
TRXB_MYCTU
A:
[10-322]
---------
A
H
H
P
V
R
D
-
V
I
V
I
G
S
G
P
A
G
Y
T
A
A
L
Y
A
A
R
A
Q
L
A
P
L
V
F
E
G
-----
T
-----
S
-----
F
G
G
A
L
M
-----
T
T
T
D
V
E
N
Y
P
G
F
R
N
G
I
T
G
P
E
L
M
D
E
M
R
E
Q
A
L
R
F
G
A
D
---
L
R
M
E
D
V
E
S
V
---
S
-------
L
H
G
-
P
----
L
K
--
S
V
V
T
---
A
D
G
Q
T
H
R
A
R
A
V
I
L
A
M
G
A
A
A
R
Y
L
Q
V
P
G
E
Q
E
----
L
L
G
----
R
G
V
S
S
C
A
T
C
D
G
--
F
--
F
F
R
D
Q
D
I
A
V
I
G
G
G
D
S
A
M
E
E
A
T
F
L
T
R
F
A
R
S
V
T
L
V
H
R
R
D
E
F
R
A
S
K
I
---
M
L
D
R
A
R
N
---
N
D
K
I
R
F
L
T
N
H
T
V
V
---
A
V
D
-
G
D
----
T
T
----
V
-
T
G
L
R
V
R
D
T
-
N
-
T
G
A
E
T
T
L
P
V
T
G
V
F
V
A
I
G
H
E
P
R
S
G
L
V
R
-
E
A
I
D
V
D
P
D
G
Y
V
L
V
Q
----
G
R
----
T
T
S
T
S
L
P
G
V
F
A
A
G
D
L
V
D
R
T
--
Y
R
Q
A
V
T
A
A
G
S
G
C
A
A
A
I
D
A
E
R
W
L
A
E
-
H
A
A
T
G
-------------
1
PsiBlast_PDB
97.01
100%
-119
- C1 -
2A87
5
TRXB_MYCTU
A:
[10-322]
---------
A
H
H
P
V
R
D
-
V
I
V
I
G
S
G
P
A
G
Y
T
A
A
L
Y
A
A
R
A
Q
L
A
P
L
V
F
E
G
-----
T
-----
S
-----
F
G
G
A
L
M
-----
T
T
T
D
V
E
N
Y
P
G
F
R
N
G
I
T
G
P
E
L
M
D
E
M
R
E
Q
A
L
R
F
G
A
D
---
L
R
M
E
D
V
E
S
V
---
S
-------
L
H
G
-
P
----
L
K
--
S
V
V
T
---
A
D
G
Q
T
H
R
A
R
A
V
I
L
A
M
G
A
A
A
R
Y
L
Q
V
P
G
E
Q
E
----
L
L
G
----
R
G
V
S
S
C
A
T
C
D
G
--
F
--
F
F
R
D
Q
D
I
A
V
I
G
G
G
D
S
A
M
E
E
A
T
F
L
T
R
F
A
R
S
V
T
L
V
H
R
R
D
E
F
R
A
S
K
I
---
M
L
D
R
A
R
N
---
N
D
K
I
R
F
L
T
N
H
T
V
V
---
A
V
D
-
G
D
----
T
T
----
V
-
T
G
L
R
V
R
D
T
-
N
-
T
G
A
E
T
T
L
P
V
T
G
V
F
V
A
I
G
H
E
P
R
S
G
L
V
R
-
E
A
I
D
V
D
P
D
G
Y
V
L
V
Q
----
G
R
----
T
T
S
T
S
L
P
G
V
F
A
A
G
D
L
V
D
R
T
--
Y
R
Q
A
V
T
A
A
G
S
G
C
A
A
A
I
D
A
E
R
W
L
A
E
-
H
A
A
T
G
-------------
21
PsiBlast_CBE
94.66
100%
-118
- C1 -
2A87
5
TRXB_MYCTU
B:
[15-318]
--------------
R
D
-
V
I
V
I
G
S
G
P
A
G
Y
T
A
A
L
Y
A
A
R
A
Q
L
A
P
L
V
F
E
G
-----
T
-----
S
-----
F
G
G
A
L
M
-----
T
T
T
D
V
E
N
Y
P
G
F
R
N
G
I
T
G
P
E
L
M
D
E
M
R
E
Q
A
L
R
F
G
A
D
---
L
R
M
E
D
V
E
S
V
---
S
-------
L
H
G
-
P
----
L
K
--
S
V
V
T
---
A
D
G
Q
T
H
R
A
R
A
V
I
L
A
M
G
A
A
A
R
Y
L
Q
V
P
G
E
Q
E
----
L
L
G
----
R
G
V
S
S
C
A
T
C
D
G
--
F
--
F
F
R
D
Q
D
I
A
V
I
G
G
G
D
S
A
M
E
E
A
T
F
L
T
R
F
A
R
S
V
T
L
V
H
R
R
D
E
F
R
A
S
K
I
---
M
L
D
R
A
R
N
---
N
D
K
I
R
F
L
T
N
H
T
V
V
---
A
V
D
-
G
D
----
T
T
----
V
-
T
G
L
R
V
R
D
T
-
N
-
T
G
A
E
T
T
L
P
V
T
G
V
F
V
A
I
G
H
E
P
R
S
G
L
V
R
-
E
A
I
D
V
D
P
D
G
Y
V
L
V
Q
----
G
R
----
T
T
S
T
S
L
P
G
V
F
A
A
G
D
L
V
D
R
T
--
Y
R
Q
A
V
T
A
A
G
S
G
C
A
A
A
I
D
A
E
R
W
L
A
E
-
H
-----------------
9
PsiBlast_PDB
83.74
50%
-112
- C1 -
1VDC
2
TRXB1_ARATH
A:
[7-324]
-----------
H
N
T
R
--
L
C
I
V
G
S
G
P
A
A
H
T
A
A
I
Y
A
A
R
A
E
L
K
P
L
L
F
E
G
WMAND
I
-----
A
-----
P
G
G
Q
L
T
-----
T
T
T
D
V
E
N
F
P
G
F
P
E
G
I
L
G
V
E
L
T
D
K
F
R
K
Q
S
E
R
F
G
T
T
---
I
F
T
E
T
V
T
K
V
---
D
-------
F
S
S
K
P
----
F
K
----
L
F
---
T
D
S
K
A
I
L
A
D
A
V
I
L
A
I
G
A
V
A
K
R
L
S
F
V
G
S
G
E
----
V
L
G
GFWN
R
G
I
S
A
C
A
V
C
D
G
--
A
AP
I
F
R
N
K
P
L
A
V
I
G
G
G
D
S
A
M
E
E
A
N
F
L
T
K
Y
G
S
K
V
Y
I
I
H
R
R
D
A
F
R
A
S
K
I
---
M
Q
Q
R
A
L
S
---
N
P
K
I
D
V
I
W
N
S
S
V
V
---
E
A
Y
-
G
D
GER-
D
V
----
L
-
G
G
L
K
V
K
N
V
-
V
-
T
G
D
V
S
D
L
K
V
S
G
L
F
F
A
I
G
H
E
P
A
T
K
F
L
D
-
G
G
V
E
L
D
S
D
G
Y
V
V
T
K
----
P
G
----
T
T
Q
T
S
V
P
G
V
F
A
A
G
D
V
Q
D
K
K
--
Y
R
Q
A
I
T
A
A
G
T
G
C
M
A
A
L
D
A
E
H
Y
L
Q
E
-------------------
38
PsiBlast_CBE
82.84
48%
-117
- C1 -
2WHD
3
?
B:
[28-343]
------------
P
L
R
T
R
V
C
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
A
A
R
A
E
L
K
P
V
L
F
E
G
WMAND
I
-----
A
-----
A
G
G
Q
L
T
-----
T
T
T
D
V
E
N
F
P
G
F
P
T
G
I
M
G
I
D
L
M
D
N
C
R
A
Q
S
V
R
F
G
T
N
---
I
L
S
E
T
V
T
E
V
---
D
-------
F
S
A
R
P
----
F
R
----
V
T
---
S
D
S
T
T
V
L
A
D
T
V
V
V
A
T
G
A
V
A
R
R
L
Y
F
S
G
S
D
T
----
Y
W
N
----
R
G
I
S
A
C
A
V
C
D
G
--
A
AP
I
F
R
N
K
P
I
A
V
I
G
G
G
D
S
A
M
E
E
G
N
F
L
T
K
Y
G
S
Q
V
Y
I
I
H
R
R
N
T
F
R
A
S
K
I
---
M
Q
A
R
A
L
S
---
N
P
K
I
Q
V
V
W
D
S
E
V
V
E
A
Y
G
G
A
-
G
G
----
G
P
----
L
-
A
G
V
K
V
K
N
L
-
V
-
T
G
E
V
S
D
L
Q
V
S
G
L
F
F
A
I
G
H
E
P
A
T
K
F
L
N
-
G
Q
L
E
L
H
A
D
G
Y
V
A
T
K
----
P
G
----
S
T
H
T
S
V
E
G
V
F
A
A
G
D
V
Q
D
K
K
--
Y
R
Q
A
I
T
A
A
G
S
G
C
M
A
A
L
D
A
E
H
Y
L
Q
E
V------------------
80
HHSearch
82.63
51%
-105
- C1 -
1VDC
2
TRXB1_ARATH
A:
[5-325]
----------
E
T
H
N
T
R
-
L
C
I
V
G
S
G
P
A
A
H
T
A
A
I
Y
A
A
R
A
E
L
K
P
L
L
F
E
G
-----
W
MANDI
A
-----
P
G
G
Q
L
T
-----
T
T
T
D
V
E
N
F
P
G
F
P
E
G
I
L
G
V
E
L
T
D
K
F
R
K
Q
S
E
R
F
G
T
T
---
I
F
T
E
T
V
T
K
V
---
D
-------
F
S
S
-
K
----
P
F
--
K
L
F
T
----
D
S
K
A
I
L
A
D
A
V
I
L
A
I
G
A
V
A
K
R
L
S
F
V
G
S
G
E
VLGG
F
W
N
----
R
G
I
S
A
C
A
V
C
D
G
AA
P
--
I
F
R
N
K
P
L
A
V
I
G
G
G
D
S
A
M
E
E
A
N
F
L
T
K
Y
G
S
K
V
Y
I
I
H
R
R
D
A
F
R
A
S
K
I
---
M
Q
Q
R
A
L
S
---
N
P
K
I
D
V
I
W
N
S
S
V
V
---
E
A
Y
-
G
D
----
G
E
RDV-
L
-
G
G
L
K
V
K
N
V
-
V
-
T
G
D
V
S
D
L
K
V
S
G
L
F
F
A
I
G
H
E
P
A
T
K
F
L
D
-
G
G
V
E
L
D
S
D
G
Y
V
V
T
K
----
P
G
----
T
T
Q
T
S
V
P
G
V
F
A
A
G
D
V
Q
D
K
K
--
Y
R
Q
A
I
T
A
A
G
T
G
C
M
A
A
L
D
A
E
H
Y
L
Q
E
-
I
-----------------
23
PsiBlast_CBE
82.54
46%
-109
- C1 -
3ITJ
4
TRXB1_YEAST
C:
[19-334]
----------
S
H
V
H
N
K
-
V
T
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
A
R
A
E
I
K
P
I
L
Y
E
G
MMANG
I
-----
A
-----
A
G
G
Q
L
T
-----
T
T
T
E
I
E
N
F
P
G
F
P
D
G
L
T
G
S
E
L
M
D
R
M
R
E
Q
S
T
K
F
G
T
E
---
I
I
T
E
T
V
S
K
V
---
D
-------
L
S
S
K
P
----
F
K
L
W
T
E
F
N
---
E
D
A
E
P
V
T
T
D
A
I
I
L
A
T
G
A
S
A
K
R
M
H
L
P
G
E
E
T
----
Y
W
Q
----
K
G
I
S
A
C
A
V
C
D
G
--
A
V--
F
R
N
K
P
L
A
V
I
G
G
G
D
S
A
C
E
E
A
Q
F
L
T
K
Y
G
S
K
V
F
M
L
V
R
K
D
H
L
R
A
S
T
------
K
R
A
E
K
---
N
E
K
I
E
I
L
Y
N
T
V
A
L
---
E
A
K
-
G
D
G---
K
L
----
L
-
N
A
L
R
I
K
N
T
-
K
-
K
N
E
E
T
D
L
P
V
S
G
L
F
Y
A
I
G
H
T
P
A
T
K
I
V
A
-
G
Q
V
D
T
D
E
A
G
Y
I
K
T
V
----
P
G
----
S
S
L
T
S
V
P
G
F
F
A
A
G
D
V
Q
D
S
K
--
Y
R
Q
A
I
T
S
A
G
S
G
C
M
A
A
L
D
A
E
K
Y
L
---------------------
18
PsiBlast_PDB
82.15
48%
-116
- C1 -
2WHD
3
?
A:
[28-343]
------------
P
L
R
T
R
V
C
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
A
A
R
A
E
L
K
P
V
L
F
E
G
WMAND
I
-----
A
-----
A
G
G
Q
L
T
-----
T
T
T
D
V
E
N
F
P
G
F
P
T
G
I
M
G
I
D
L
M
D
N
C
R
A
Q
S
V
R
F
G
T
N
---
I
L
S
E
T
V
T
E
V
---
D
-------
F
S
A
R
P
----
F
R
----
V
T
---
S
D
S
T
T
V
L
A
D
T
V
V
V
A
T
G
A
V
A
R
R
L
Y
F
S
G
S
D
T
----
Y
W
N
----
R
G
I
S
A
C
A
V
C
D
G
--
A
AP
I
F
R
N
K
P
I
A
V
I
G
G
G
D
S
A
M
E
E
G
N
F
L
T
K
Y
G
S
Q
V
Y
I
I
H
R
R
N
T
F
R
A
S
K
I
---
M
Q
A
R
A
L
S
---
N
P
K
I
Q
V
V
W
D
S
E
V
V
E
A
Y
G
G
A
-
G
G
----
G
P
----
L
-
A
G
V
K
V
K
N
L
-
V
-
T
G
E
V
S
D
L
Q
V
S
G
L
F
F
A
I
G
H
E
P
A
T
K
F
L
N
-
G
Q
L
E
L
H
A
D
G
Y
V
A
T
K
----
P
G
----
S
T
H
T
S
V
E
G
V
F
A
A
G
D
V
Q
D
K
K
--
Y
R
Q
A
I
T
A
A
G
S
G
C
M
A
A
L
D
A
E
H
Y
L
Q
E
V------------------
8
PsiBlast_PDB
81.83
46%
-111
- C1 -
3D8X
3
TRXB1_YEAST
A:
[11-322]
--------------
N
K
-
V
T
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
A
R
A
E
I
K
P
I
L
Y
E
G
MMANG
I
-----
A
-----
A
G
G
Q
L
T
-----
T
T
T
E
I
E
N
F
P
G
F
P
D
G
L
T
G
S
E
L
M
D
R
M
R
E
Q
S
T
K
F
G
T
E
---
I
I
T
E
T
V
S
K
V
---
D
-------
L
S
S
K
P
----
F
K
L
W
T
E
F
N
---
E
D
A
E
P
V
T
T
D
A
I
I
L
A
T
G
A
S
A
K
R
M
H
L
P
G
E
E
T
----
Y
W
Q
----
K
G
I
S
A
C
A
V
C
D
G
--
A
VP
I
F
R
N
K
P
L
A
V
I
G
G
G
D
S
A
C
E
E
A
Q
F
L
T
K
Y
G
S
K
V
F
M
L
V
R
K
D
H
L
R
A
S
T
I
---
M
Q
K
R
A
E
K
---
N
E
K
I
E
I
L
Y
N
T
V
A
L
---
E
A
K
-
G
D
G---
K
L
----
L
-
N
A
L
R
I
K
N
T
-
K
-
K
N
E
E
T
D
L
P
V
S
G
L
F
Y
A
I
G
H
T
P
A
T
K
I
V
A
-
G
Q
V
D
T
D
E
A
G
Y
I
K
T
V
----
P
G
----
S
S
L
T
S
V
P
G
F
F
A
A
G
D
V
Q
D
S
K
--
Y
R
Q
A
I
T
S
A
G
S
G
C
M
A
A
L
D
A
E
K
Y
L
---------------------
72
HHSearch
81.46
46%
-110
- C1 -
4JNQ
2
?
A:
[21-338]
--------
S
M
T
Q
R
H
A
P
-
V
I
V
I
G
S
G
P
A
G
Y
T
A
A
I
Y
A
A
R
A
M
L
K
P
V
V
I
A
G
-----
L
-----
Q
-----
Q
G
G
Q
L
M
-----
I
T
T
D
V
E
N
Y
P
G
Y
A
E
P
V
Q
G
P
W
M
M
E
Q
M
A
R
Q
A
E
N
V
G
A
Q
---
I
V
H
D
I
I
T
E
V
---
E
-------
T
T
V
-
R
----
P
F
--
R
L
K
G
---
D
S
G
T
I
Y
T
C
D
A
L
I
I
A
T
G
A
Q
A
K
W
L
G
L
E
S
E
Q
T
----
F
M
G
----
G
G
V
S
A
C
A
T
C
D
G
--
F
--
F
Y
R
G
K
D
V
V
V
V
G
G
G
N
T
A
V
E
E
A
L
Y
L
S
H
I
A
K
S
V
T
I
V
H
R
R
D
G
F
R
A
E
K
I
---
M
Q
D
R
L
L
S
---
R
E
N
V
S
V
V
W
N
S
V
I
D
---
E
I
L
-
G
T
----
E
A
RGAT
V
-
T
G
V
R
L
K
N
I
-
V
-
T
G
E
T
Q
E
R
A
T
H
G
V
F
I
A
I
G
H
A
P
A
V
S
L
F
E
-
G
K
L
K
Q
K
P
N
G
Y
L
W
T
A
----
P
D
----
S
T
A
T
D
V
P
G
I
F
A
A
G
D
V
T
D
D
I
--
Y
R
Q
A
V
T
A
A
G
M
G
C
M
A
A
L
E
A
E
R
W
L
A
A
-
Q
E
----------------
28
PsiBlast_CBE
81.38
46%
-110
- C1 -
3D8X
2
TRXB1_YEAST
B:
[11-322]
--------------
N
K
-
V
T
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
A
R
A
E
I
K
P
I
L
Y
E
G
MMANG
I
-----
A
-----
A
G
G
Q
L
T
-----
T
T
T
E
I
E
N
F
P
G
F
P
D
G
L
T
G
S
E
L
M
D
R
M
R
E
Q
S
T
K
F
G
T
E
---
I
I
T
E
T
V
S
K
V
---
D
-------
L
S
S
K
P
----
F
K
LW
T
E
F
N
---
E
D
A
E
P
V
T
T
D
A
I
I
L
A
T
G
A
S
A
K
R
M
H
L
P
G
E
E
T
----
Y
W
Q
----
K
G
I
S
A
C
A
V
C
D
G
--
A
VP
I
F
R
N
K
P
L
A
V
I
G
G
G
D
S
A
C
E
E
A
Q
F
L
T
K
Y
G
S
K
V
F
M
L
V
R
K
D
H
L
R
A
S
T
I
---
M
Q
K
R
A
E
K
---
N
E
K
I
E
I
L
Y
N
T
V
A
L
---
E
A
K
-
G
D
G---
K
L
----
L
-
N
A
L
R
I
K
N
T
-
K
-
K
N
E
E
T
D
L
P
V
S
G
L
F
Y
A
I
G
H
T
P
A
T
K
I
V
A
-
G
Q
V
D
T
D
E
A
G
Y
I
K
T
V
----
P
G
----
S
S
L
T
S
V
P
G
F
F
A
A
G
D
V
Q
D
S
K
--
Y
R
Q
A
I
T
S
A
G
S
G
C
M
A
A
L
D
A
E
K
Y
L
---------------------
15
PsiBlast_PDB
81.35
46%
-118
- C1 -
4JNQ
2
?
A:
[26-338]
----------
H
A
P
V
----
I
V
I
G
S
G
P
A
G
Y
T
A
A
I
Y
A
A
R
A
M
L
K
P
V
V
I
A
G
-----
L
-----
Q
-----
Q
G
G
Q
L
M
-----
I
T
T
D
V
E
N
Y
P
G
Y
A
E
P
V
Q
G
P
W
M
M
E
Q
M
A
R
Q
A
E
N
V
G
A
Q
---
I
V
H
D
I
I
T
E
V
---
E
TTVRP
F
R
L
K
G
-
D
----
S
G
--
T
I
Y
T
---
C
D
-------
A
L
I
I
A
T
G
A
Q
A
K
W
L
G
L
E
S
E
Q
T
----
F
M
G
----
G
G
V
S
A
C
A
T
C
D
G
--
F
--
F
Y
R
G
K
D
V
V
V
V
G
G
G
N
T
A
V
E
E
A
L
Y
L
S
H
I
A
K
S
V
T
I
V
H
R
R
D
G
F
R
A
E
K
I
---
M
Q
D
R
L
L
S
---
R
E
N
V
S
V
V
W
N
S
V
I
D
---
E
I
L
-
G
T
E
ARG
A
T
----
V
-
T
G
V
R
L
K
N
I
-
V
-
T
G
E
T
Q
E
R
A
T
H
G
V
F
I
A
I
G
H
A
P
A
V
S
L
F
E
-
G
K
L
K
Q
K
P
N
G
Y
L
W
T
A
----
P
D
----
S
T
A
T
D
V
P
G
I
F
A
A
G
D
V
T
D
D
I
--
Y
R
Q
A
V
T
A
A
G
M
G
C
M
A
A
L
E
A
E
R
W
L
A
A
-
Q
E
----------------
5
PsiBlast_PDB
81.20
48%
-117
- C1 -
1TDF
2
TRXB_ECOLI
A:
[8-313]
-----------------
L
L
I
L
G
S
G
P
A
G
Y
T
A
A
V
Y
A
A
R
A
N
L
Q
P
V
L
I
T
G
-----
M
-----
E
-----
K
G
G
Q
L
T
-----
T
T
T
E
V
E
N
W
P
G
D
P
N
D
L
T
G
P
L
L
M
E
R
M
H
E
H
A
T
K
F
E
T
E
---
I
I
F
D
H
I
N
K
V
---
D
-------
L
Q
N
R
P
----
F
R
----
L
N
---
G
D
N
G
E
Y
T
C
D
A
L
I
I
A
T
G
A
S
A
R
Y
L
G
L
P
S
E
E
A
----
F
K
G
----
R
G
V
S
A
C
A
T
S
D
G
--
F
--
F
Y
R
N
Q
K
V
A
V
I
G
G
G
N
T
A
V
E
E
A
L
Y
L
S
N
I
A
S
E
V
H
L
I
H
R
R
D
G
F
R
A
E
K
I
---
L
I
K
R
L
M
D
K
V
E
N
G
N
I
I
L
H
T
N
R
T
L
E
---
E
V
T
-
G
D
----
Q
M
G---
V
-
T
G
V
R
L
R
D
T
Q
N
-
S
D
N
I
E
S
L
D
V
A
G
L
F
V
A
I
G
H
S
P
N
T
A
I
F
E
-
G
Q
L
E
L
E
-
N
G
Y
I
K
V
Q
SGIH
G
N
----
A
T
Q
T
S
I
P
G
V
F
A
A
G
D
V
M
D
H
I
--
Y
R
Q
A
I
T
S
A
G
T
G
C
M
A
A
L
D
A
E
R
Y
L
---------------------
24
PsiBlast_CBE
81.14
46%
-105
- C1 -
3ITJ
4
TRXB1_YEAST
B:
[20-334]
-----------
H
V
H
N
K
-
V
T
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
A
R
A
E
I
K
P
I
L
Y
E
G
MMANG
I
-----
A
-----
A
G
G
Q
L
T
-----
T
T
T
E
I
E
N
F
P
G
F
P
D
G
L
T
G
S
E
L
M
D
R
M
R
E
Q
S
T
K
F
G
T
E
---
I
I
T
E
T
V
S
K
V
---
D
-------
L
S
S
K
P
----
F
K
L
W
T
E
F
N
---
E
D
A
E
P
V
T
T
D
A
I
I
L
A
T
G
A
S
A
K
R
M
H
L
P
G
E
E
T
----
Y
W
Q
----
K
G
I
S
A
C
A
V
C
D
G
--
A
VP
I
F
R
N
K
P
L
A
V
I
G
G
G
D
S
A
C
E
E
A
Q
F
L
T
K
Y
G
S
K
V
F
M
L
V
R
K
D
H
L
R
A
S
T
I
---
M
Q
K
R
A
E
K
---
N
E
K
I
E
I
L
Y
N
T
V
A
L
---
E
A
K
-
G
D
G---
K
L
----
L
-
N
A
L
R
I
K
N
T
-
K
-
K
N
E
E
T
D
L
P
V
S
G
L
F
Y
A
I
G
H
T
P
A
T
K
I
V
A
-
G
Q
V
D
T
D
E
A
G
Y
I
K
T
V
----
P
G
----
S
S
L
T
S
V
P
G
F
F
A
A
G
D
V
Q
D
S
K
--
Y
R
Q
A
I
T
S
A
G
S
G
C
M
A
A
L
D
A
E
K
Y
L
---------------------
4
PsiBlast_PDB
81.00
46%
-103
- C1 -
3ITJ
3
TRXB1_YEAST
A:
[21-334]
------------
V
H
N
K
-
V
T
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
A
R
A
E
I
K
P
I
L
Y
E
G
MMANG
I
-----
A
-----
A
G
G
Q
L
T
-----
T
T
T
E
I
E
N
F
P
G
F
P
D
G
L
T
G
S
E
L
M
D
R
M
R
E
Q
S
T
K
F
G
T
E
---
I
I
T
E
T
V
S
K
V
---
D
-------
L
S
S
K
P
----
F
K
L
W
T
E
F
N
---
E
D
A
E
P
V
T
T
D
A
I
I
L
A
T
G
A
S
A
K
R
M
H
L
P
G
E
E
T
----
Y
W
Q
----
K
G
I
S
A
C
A
V
C
D
G
--
A
VP
I
F
R
N
K
P
L
A
V
I
G
G
G
D
S
A
C
E
E
A
Q
F
L
T
K
Y
G
S
K
V
F
M
L
V
R
K
D
H
L
R
A
S
T
I
---
M
Q
K
R
A
E
K
---
N
E
K
I
E
I
L
Y
N
T
V
A
L
---
E
A
K
-
G
D
G---
K
L
----
L
-
N
A
L
R
I
K
N
T
-
K
-
K
N
E
E
T
D
L
P
V
S
G
L
F
Y
A
I
G
H
T
P
A
T
K
I
V
A
-
G
Q
V
D
T
D
E
A
G
Y
I
K
T
V
----
P
G
----
S
S
L
T
S
V
P
G
F
F
A
A
G
D
V
Q
D
S
K
--
Y
R
Q
A
I
T
S
A
G
S
G
C
M
A
A
L
D
A
E
K
Y
L
---------------------
73
HHSearch
80.93
47%
-103
* C1 *
3ITJ
3
TRXB1_YEAST
A:
[21-336]
------------
V
H
N
K
-
V
T
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
A
R
A
E
I
K
P
I
L
Y
E
G
-----
M
-----
M
ANGIA
A
G
G
Q
L
T
-----
T
T
T
E
I
E
N
F
P
G
F
P
D
G
L
T
G
S
E
L
M
D
R
M
R
E
Q
S
T
K
F
G
T
E
---
I
I
T
E
T
V
S
K
V
---
D
-------
L
S
S
-
K
----
P
F
--
K
L
W
T
EFN
E
D
A
E
P
V
T
T
D
A
I
I
L
A
T
G
A
S
A
K
R
M
H
L
P
G
E
E
T
----
Y
W
Q
----
K
G
I
S
A
C
A
V
C
D
G
--
A
VP
I
F
R
N
K
P
L
A
V
I
G
G
G
D
S
A
C
E
E
A
Q
F
L
T
K
Y
G
S
K
V
F
M
L
V
R
K
D
H
L
R
A
S
T
I
---
M
Q
K
R
A
E
K
---
N
E
K
I
E
I
L
Y
N
T
V
A
L
---
E
A
K
-
G
D
----
G
K
----
L
L
N
A
L
R
I
K
N
T
-
K
-
K
N
E
E
T
D
L
P
V
S
G
L
F
Y
A
I
G
H
T
P
A
T
K
I
V
A
-
G
Q
V
D
T
D
E
A
G
Y
I
K
T
V
----
P
G
----
S
S
L
T
S
V
P
G
F
F
A
A
G
D
V
Q
D
S
K
--
Y
R
Q
A
I
T
S
A
G
S
G
C
M
A
A
L
D
A
E
K
Y
L
T
S
-------------------
3
PsiBlast_PDB
80.91
49%
-118
- C1 -
1CL0
1
TRXB_ECOLI
A:
[8-313]
-----------------
L
L
I
L
G
S
G
P
A
G
Y
T
A
A
V
Y
A
A
R
A
N
L
Q
P
V
L
I
T
G
-----
M
-----
E
-----
K
G
G
Q
L
T
-----
T
T
T
E
V
E
N
W
P
G
D
P
N
D
L
T
G
P
L
L
M
E
R
M
H
E
H
A
T
K
F
E
T
E
---
I
I
F
D
H
I
N
K
V
---
D
-------
L
Q
N
R
P
----
F
R
----
L
N
---
G
D
N
G
E
Y
T
C
D
A
L
I
I
A
T
G
A
S
A
R
Y
L
G
L
P
S
E
E
A
----
F
K
G
----
R
G
V
S
A
C
A
T
C
D
G
--
F
--
F
Y
R
N
Q
K
V
A
V
I
G
G
G
N
T
A
V
E
E
A
L
Y
L
S
N
I
A
S
E
V
H
L
I
H
R
R
D
G
F
R
A
E
K
I
---
L
I
K
R
L
M
D
K
V
E
N
G
N
I
I
L
H
T
N
R
T
L
E
---
E
V
T
-
G
D
----
Q
M
G---
V
-
T
G
V
R
L
R
D
T
Q
N
-
S
D
N
I
E
S
L
D
V
A
G
L
F
V
A
I
G
H
S
P
N
T
A
I
F
E
-
G
Q
L
E
L
E
-
N
G
Y
I
K
V
Q
SGIH
G
N
----
A
T
Q
T
S
I
P
G
V
F
A
A
G
D
V
M
D
H
I
--
Y
R
Q
A
I
T
S
A
G
T
G
C
M
A
A
L
D
A
E
R
Y
L
---------------------
2
PsiBlast_PDB
80.85
49%
-115
- C1 -
1TDE
1
TRXB_ECOLI
A:
[8-313]
-----------------
L
L
I
L
G
S
G
P
A
G
Y
T
A
A
V
Y
A
A
R
A
N
L
Q
P
V
L
I
T
G
-----
M
-----
E
-----
K
G
G
Q
L
T
-----
T
T
T
E
V
E
N
W
P
G
D
P
N
D
L
T
G
P
L
L
M
E
R
M
H
E
H
A
T
K
F
E
T
E
---
I
I
F
D
H
I
N
K
V
---
D
-------
L
Q
N
R
P
----
F
R
----
L
N
---
G
D
N
G
E
Y
T
C
D
A
L
I
I
A
T
G
A
S
A
R
Y
L
G
L
P
S
E
E
A
----
F
K
G
----
R
G
V
S
A
C
A
T
C
D
G
--
F
--
F
Y
R
N
Q
K
V
A
V
I
G
G
G
N
T
A
V
E
E
A
L
Y
L
S
N
I
A
S
E
V
H
L
I
H
R
R
D
G
F
R
A
E
K
I
---
L
I
K
R
L
M
D
K
V
E
N
G
N
I
I
L
H
T
N
R
T
L
E
---
E
V
T
-
G
D
----
Q
M
G---
V
-
T
G
V
R
L
R
D
T
Q
N
-
S
D
N
I
E
S
L
D
V
A
G
L
F
V
A
I
G
H
S
P
N
T
A
I
F
E
-
G
Q
L
E
L
E
-
N
G
Y
I
K
V
Q
SGIH
G
N
----
A
T
Q
T
S
I
P
G
V
F
A
A
G
D
V
M
D
H
I
--
Y
R
Q
A
I
T
S
A
G
T
G
C
M
A
A
L
D
A
E
R
Y
L
---------------------
31
PsiBlast_CBE
80.79
43%
-106
- C1 -
4CCR
3
?
B:
[4-314]
-------------
I
H
D
-
V
V
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
G
R
S
S
L
K
P
V
M
Y
E
G
FMAGG
V
-----
A
-----
A
G
G
Q
L
T
-----
T
T
T
I
I
E
N
F
P
G
F
P
N
G
I
D
G
N
E
L
M
M
N
M
R
T
Q
S
E
K
Y
G
T
T
---
I
I
T
E
T
I
D
H
V
---
D
-------
F
S
T
-
Q
----
P
F
--
K
L
F
T
---
E
E
G
K
E
V
L
T
K
S
V
I
I
A
T
G
A
T
A
K
R
M
H
V
P
G
E
D
K
----
Y
W
Q
----
N
G
V
S
A
C
A
I
C
D
G
--
A
VP
I
F
R
N
K
V
L
M
V
V
G
G
G
D
A
A
M
E
E
A
L
H
L
T
K
Y
G
S
K
V
I
I
L
H
R
R
D
A
F
R
A
S
K
T
---
M
Q
E
R
V
L
N
---
H
P
K
I
E
V
I
W
N
S
E
L
V
---
E
L
E
-
G
D
G---
D
L
----
L
-
N
G
A
K
I
H
N
L
-
V
-
S
G
E
Y
K
V
V
P
V
A
G
L
F
Y
A
I
G
H
S
P
N
S
K
F
L
G
-
G
Q
V
K
T
A
D
D
G
Y
I
L
T
E
----
G
------
P
K
T
S
V
D
G
V
F
A
C
G
D
V
C
D
R
V
--
Y
R
Q
A
I
V
A
A
G
S
G
C
M
A
A
L
S
C
E
K
W
L
Q
T
-
H
-----------------
34
PsiBlast_CBE
80.67
43%
-108
- C1 -
4A65
6
?
B:
[4-314]
-------------
I
H
D
-
V
V
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
G
R
S
S
L
K
P
V
M
Y
E
G
FMAGG
V
-----
A
-----
A
G
G
Q
L
T
-----
T
T
T
I
I
E
N
F
P
G
F
P
N
G
I
D
G
N
E
L
M
M
N
M
R
T
Q
S
E
K
Y
G
T
T
---
I
I
T
E
T
I
D
H
V
---
D
-------
F
S
T
-
Q
----
P
F
--
K
L
F
T
---
E
E
G
K
E
V
L
T
K
S
V
I
I
A
T
G
A
T
A
K
R
M
H
V
P
G
E
D
K
----
Y
W
Q
----
N
G
V
S
A
C
A
I
C
D
G
--
A
VP
I
F
R
N
K
V
L
M
V
V
G
G
G
D
A
A
M
E
E
A
L
H
L
T
K
Y
G
S
K
V
I
I
L
H
R
R
D
A
F
R
A
S
K
T
---
M
Q
E
R
V
L
N
---
H
P
K
I
E
V
I
W
N
S
E
L
V
---
E
L
E
-
G
D
G---
D
L
----
L
-
N
G
A
K
I
H
N
L
-
V
-
S
G
E
Y
K
V
V
P
V
A
G
L
F
Y
A
I
G
H
S
P
N
S
K
F
L
G
-
G
Q
V
K
T
A
D
D
G
Y
I
L
T
E
----
G
------
P
K
T
S
V
D
G
V
F
A
C
G
D
V
C
D
R
V
--
Y
R
Q
A
I
V
A
A
G
S
G
C
M
A
A
L
S
C
E
K
W
L
Q
T
-
H
-----------------
37
PsiBlast_CBE
80.53
43%
-107
- C1 -
4UP3
4
?
B:
[4-314]
-------------
I
H
D
-
V
V
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
G
R
S
S
L
K
P
V
M
Y
E
G
FMAGG
V
-----
A
-----
A
G
G
Q
L
T
-----
T
T
T
I
I
E
N
F
P
G
F
P
N
G
I
D
G
N
E
L
M
M
N
M
R
T
Q
S
E
K
Y
G
T
T
---
I
I
T
E
T
I
D
H
V
---
D
-------
F
S
T
-
Q
----
P
F
--
K
L
F
T
---
E
E
G
K
E
V
L
T
K
S
V
I
I
A
T
G
A
T
A
K
R
M
H
V
P
G
E
D
K
----
Y
W
Q
----
N
G
V
S
A
S
A
I
C
D
G
--
A
VP
I
F
R
N
K
V
L
M
V
V
G
G
G
D
A
A
M
E
E
A
L
H
L
T
K
Y
G
S
K
V
I
I
L
H
R
R
D
A
F
R
A
S
K
T
---
M
Q
E
R
V
L
N
---
H
P
K
I
E
V
I
W
N
S
E
L
V
---
E
L
E
-
G
D
G---
D
L
----
L
-
N
G
A
K
I
H
N
L
-
V
-
S
G
E
Y
K
V
V
P
V
A
G
L
F
Y
A
I
G
H
S
P
N
S
K
F
L
G
-
G
Q
V
K
T
A
D
D
G
Y
I
L
T
E
----
G
------
P
K
T
S
V
D
G
V
F
A
C
G
D
V
Q
D
R
V
--
Y
R
Q
A
I
V
A
A
G
S
G
C
M
A
A
L
S
C
E
K
W
L
Q
T
-
H
-----------------
14
PsiBlast_PDB
80.46
43%
-109
- C1 -
4CCR
3
?
A:
[4-314]
-------------
I
H
D
-
V
V
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
G
R
S
S
L
K
P
V
M
Y
E
G
FMAGG
V
-----
A
-----
A
G
G
Q
L
T
-----
T
T
T
I
I
E
N
F
P
G
F
P
N
G
I
D
G
N
E
L
M
M
N
M
R
T
Q
S
E
K
Y
G
T
T
---
I
I
T
E
T
I
D
H
V
---
D
-------
F
S
T
-
Q
----
P
F
--
K
L
F
T
---
E
E
G
K
E
V
L
T
K
S
V
I
I
A
T
G
A
T
A
K
R
M
H
V
P
G
E
D
K
----
Y
W
Q
----
N
G
V
S
A
C
A
I
C
D
G
--
A
VP
I
F
R
N
K
V
L
M
V
V
G
G
G
D
A
A
M
E
E
A
L
H
L
T
K
Y
G
S
K
V
I
I
L
H
R
R
D
A
F
R
--
K
T
---
M
Q
E
R
V
L
N
---
H
P
K
I
E
V
I
W
N
S
E
L
V
---
E
L
E
-
G
D
G---
D
L
----
L
-
N
G
A
K
I
H
N
L
-
V
-
S
G
E
Y
K
V
V
P
V
A
G
L
F
Y
A
I
G
H
S
P
N
S
K
F
L
G
-
G
Q
V
K
T
A
D
D
G
Y
I
L
T
E
----
G
------
P
K
T
S
V
D
G
V
F
A
C
G
D
V
C
D
R
V
--
Y
R
Q
A
I
V
A
A
G
S
G
C
M
A
A
L
S
C
E
K
W
L
Q
T
-
H
-----------------
16
PsiBlast_PDB
80.42
44%
-106
- C1 -
2Q7V
2
?
A:
[2-314]
-
T
A
P
T
A
H
D
Y
------
D
-
V
V
I
I
G
G
G
P
A
G
L
T
A
A
I
Y
T
G
R
A
Q
L
S
T
L
I
L
E
K
-----
G
-----
M
-----
P
G
G
Q
I
A
-----
W
S
E
E
V
E
N
F
P
G
F
P
E
P
I
A
G
M
E
L
A
Q
R
M
H
Q
Q
A
E
K
F
G
A
K
---
V
E
M
D
E
V
Q
G
V
Q
H
D
A
-------
T
S
H
-
P
----
Y
P
--
F
T
V
R
---
G
Y
N
G
E
Y
R
A
K
A
V
I
L
A
T
G
A
D
P
R
K
L
G
I
P
G
E
D
N
----
F
W
G
----
K
G
V
S
T
C
A
T
C
D
G
--
F
--
F
Y
K
G
K
K
V
V
V
I
G
G
G
D
A
A
V
E
E
G
M
F
L
T
K
F
A
D
E
V
T
V
I
H
R
R
D
T
L
R
A
N
K
V
---
A
Q
A
R
A
F
A
---
N
P
K
M
K
F
I
W
D
T
A
V
E
---
E
I
Q
-
G
A
----
D
S
----
V
-
S
G
V
K
L
R
N
L
-
K
-
T
G
E
V
S
E
L
A
T
D
G
V
F
I
F
I
G
H
V
P
N
T
A
F
V
K
-
D
T
V
S
L
R
D
D
G
Y
V
D
V
R
----
D
E
-----
I
Y
T
N
I
P
M
L
F
A
A
G
D
V
S
D
Y
I
--
Y
R
Q
L
A
T
S
V
G
A
G
T
R
A
A
M
M
T
E
R
Q
L
A
A
-
L
-----------------
36
PsiBlast_CBE
80.30
44%
-109
- C1 -
2Q7V
2
?
B:
[6-314]
-----
A
H
D
Y
------
D
-
V
V
I
I
G
G
G
P
A
G
L
T
A
A
I
Y
T
G
R
A
Q
L
S
T
L
I
L
E
K
-----
G
-----
M
-----
P
G
G
Q
I
A
-----
W
S
E
E
V
E
N
F
P
G
F
P
E
P
I
A
G
M
E
L
A
Q
R
M
H
Q
Q
A
E
K
F
G
A
K
---
V
E
M
D
E
V
Q
G
V
Q
H
D
A
-------
T
S
H
-
P
----
Y
P
--
F
T
V
R
---
G
Y
N
G
E
Y
R
A
K
A
V
I
L
A
T
G
A
D
P
R
K
L
G
I
P
G
E
D
N
----
F
W
G
----
K
G
V
S
T
C
A
T
C
D
G
--
F
--
F
Y
K
G
K
K
V
V
V
I
G
G
G
D
A
A
V
E
E
G
M
F
L
T
K
F
A
D
E
V
T
V
I
H
R
R
D
T
L
R
A
N
K
V
---
A
Q
A
R
A
F
A
---
N
P
K
M
K
F
I
W
D
T
A
V
E
---
E
I
Q
-
G
A
----
D
S
----
V
-
S
G
V
K
L
R
N
L
-
K
-
T
G
E
V
S
E
L
A
T
D
G
V
F
I
F
I
G
H
V
P
N
T
A
F
V
K
-
D
T
V
S
L
R
D
D
G
Y
V
D
V
R
----
D
E
-----
I
Y
T
N
I
P
M
L
F
A
A
G
D
V
S
D
Y
I
--
Y
R
Q
L
A
T
S
V
G
A
G
T
R
A
A
M
M
T
E
R
Q
L
A
A
-
L
-----------------
78
HHSearch
80.28
44%
-111
- C1 -
2Q7V
2
?
A:
[6-314]
-----------
A
H
D
Y
D
-
V
V
I
I
G
G
G
P
A
G
L
T
A
A
I
Y
T
G
R
A
Q
L
S
T
L
I
L
E
K
-----
G
-----
M
-----
P
G
G
Q
I
A
-----
W
S
E
E
V
E
N
F
P
G
F
P
E
P
I
A
G
M
E
L
A
Q
R
M
H
Q
Q
A
E
K
F
G
A
K
---
V
E
M
D
E
V
Q
G
V
---
Q
-------
H
D
A
-
T
SHPY
P
F
--
T
V
R
G
----
Y
N
G
E
Y
R
A
K
A
V
I
L
A
T
G
A
D
P
R
K
L
G
I
P
G
E
D
N
----
F
W
G
----
K
G
V
S
T
C
A
T
C
D
G
--
F
--
F
Y
K
G
K
K
V
V
V
I
G
G
G
D
A
A
V
E
E
G
M
F
L
T
K
F
A
D
E
V
T
V
I
H
R
R
D
T
L
R
A
N
K
V
---
A
Q
A
R
A
F
A
---
N
P
K
M
K
F
I
W
D
T
A
V
E
---
E
I
Q
-
G
A
----
D
S
----
V
-
S
G
V
K
L
R
N
L
-
K
-
T
G
E
V
S
E
L
A
T
D
G
V
F
I
F
I
G
H
V
P
N
T
A
F
V
K
-
D
T
V
S
L
R
D
D
G
Y
V
D
V
R
----
D
-----
E
I
Y
T
N
I
P
M
L
F
A
A
G
D
V
S
D
Y
I
--
Y
R
Q
L
A
T
S
V
G
A
G
T
R
A
A
M
M
T
E
R
Q
L
A
A
-
L
-----------------
7
PsiBlast_PDB
80.11
48%
-116
- C1 -
1TRB
1
TRXB_ECOLI
A:
[8-313]
-----------------
L
L
I
L
G
S
G
P
A
G
Y
T
A
A
V
Y
A
A
R
A
N
L
Q
P
V
L
I
T
G
-----
M
-----
E
-----
K
G
G
Q
L
T
-----
T
T
T
E
V
E
N
W
P
G
D
P
N
D
L
T
G
P
L
L
M
E
R
M
H
E
H
A
T
K
F
E
T
E
---
I
I
F
D
H
I
N
K
V
---
D
-------
L
Q
N
R
P
----
F
R
----
L
N
---
G
D
N
G
E
Y
T
C
D
A
L
I
I
A
T
G
A
S
A
R
Y
L
G
L
P
S
E
E
A
----
F
K
G
----
R
G
V
S
A
C
A
T
S
D
G
--
F
--
F
Y
R
N
Q
K
V
A
V
I
G
G
G
N
T
A
V
E
E
A
L
Y
L
S
N
I
A
S
E
V
H
L
I
H
R
R
D
G
F
R
A
E
K
I
---
L
I
K
R
L
M
D
K
V
E
N
G
N
I
I
L
H
T
N
R
T
L
E
---
E
V
T
-
G
D
----
Q
M
G---
V
-
T
G
V
R
L
R
D
T
Q
N
-
S
D
N
I
E
S
L
D
V
A
G
L
F
V
A
I
G
H
S
P
N
T
A
I
F
E
-
G
Q
L
E
L
E
-
N
G
Y
I
K
V
Q
SGIH
G
N
----
A
T
Q
T
S
I
P
G
V
F
A
A
G
D
V
M
D
H
I
--
Y
R
Q
A
I
T
S
A
G
T
G
C
M
A
A
L
D
A
E
R
Y
L
---------------------
30
PsiBlast_CBE
80.08
43%
-106
- C1 -
4CCR
3
?
C:
[4-314]
-------------
I
H
D
-
V
V
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
G
R
S
S
L
K
P
V
M
Y
E
G
FMAGG
V
-----
A
-----
A
G
G
Q
L
T
-----
T
T
T
I
I
E
N
F
P
G
F
P
N
G
I
D
G
N
E
L
M
M
N
M
R
T
Q
S
E
K
Y
G
T
T
---
I
I
T
E
T
I
D
H
V
---
D
-------
F
S
T
-
Q
----
P
F
--
K
L
F
T
---
E
E
G
K
E
V
L
T
K
S
V
I
I
A
T
G
A
T
A
K
R
M
H
V
P
G
E
D
K
----
Y
W
Q
----
N
G
V
S
A
C
A
I
C
D
G
--
A
VP
I
F
R
N
K
V
L
M
V
V
G
G
G
D
A
A
M
E
E
A
L
H
L
T
K
Y
G
S
K
V
I
I
L
H
R
R
D
A
F
R
A
S
K
T
---
M
Q
E
R
V
L
N
---
H
P
K
I
E
V
I
W
N
S
E
L
V
---
E
L
E
-
G
D
G---
D
L
----
L
-
N
G
A
K
I
H
N
L
-
V
-
S
G
E
Y
K
V
V
P
V
A
G
L
F
Y
A
I
G
H
S
P
N
S
K
F
L
G
-
G
Q
V
K
T
A
D
D
G
Y
I
L
T
E
----
G
------
P
K
T
S
V
D
G
V
F
A
C
G
D
V
C
D
R
V
--
Y
R
Q
A
I
V
A
A
G
S
G
C
M
A
A
L
S
C
E
K
W
L
Q
T
-
H
-----------------
12
PsiBlast_PDB
80.03
43%
-110
- C1 -
4CBQ
9
?
A:
[4-314]
-------------
I
H
D
-
V
V
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
G
R
S
S
L
K
P
V
M
Y
E
G
FMAGG
V
-----
A
-----
A
G
G
Q
L
T
-----
T
T
T
I
I
E
N
F
P
G
F
P
N
G
I
D
G
N
E
L
M
M
N
M
R
T
Q
S
E
K
Y
G
T
T
---
I
I
T
E
T
I
D
H
V
---
D
-------
F
S
T
-
Q
----
P
F
--
K
L
F
T
---
E
E
G
K
E
V
L
T
K
S
V
I
I
A
T
G
A
T
A
K
R
M
H
V
P
G
E
D
K
----
Y
W
Q
----
N
G
V
S
A
C
A
I
C
D
G
--
A
VP
I
F
R
N
K
V
L
M
V
V
G
G
G
D
A
A
M
E
E
A
L
H
L
T
K
Y
G
S
K
V
I
I
L
H
R
R
D
A
F
R
A
S
K
T
---
M
Q
E
R
V
L
N
---
H
P
K
I
E
V
I
W
N
S
E
L
V
---
E
L
E
-
G
D
G---
D
L
----
L
-
N
G
A
K
I
H
N
L
-
V
-
S
G
E
Y
K
V
V
P
V
A
G
L
F
Y
A
I
G
H
S
P
N
S
K
F
L
G
-
G
Q
V
K
T
A
D
D
G
Y
I
L
T
E
----
G
------
P
K
T
S
V
D
G
V
F
A
C
G
D
V
C
D
R
V
--
Y
R
Q
A
I
V
A
A
G
S
G
C
M
A
A
L
S
C
E
K
W
L
Q
T
-
H
-----------------
35
PsiBlast_CBE
79.92
43%
-107
- C1 -
4A5L
3
?
B:
[4-314]
-------------
I
H
D
-
V
V
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
G
R
S
S
L
K
P
V
M
Y
E
G
FMAGG
V
-----
A
-----
A
G
G
Q
L
T
-----
T
T
T
I
I
E
N
F
P
G
F
P
N
G
I
D
G
N
E
L
M
M
N
M
R
T
Q
S
E
K
Y
G
T
T
---
I
I
T
E
T
I
D
H
V
---
D
-------
F
S
T
-
Q
----
P
F
--
K
L
F
T
---
E
E
G
K
E
V
L
T
K
S
V
I
I
A
T
G
A
T
A
K
R
M
H
V
P
G
E
D
K
----
Y
W
Q
----
N
G
V
S
A
C
A
I
C
D
G
--
A
VP
I
F
R
N
K
V
L
M
V
V
G
G
G
D
A
A
M
E
E
A
L
H
L
T
K
Y
G
S
K
V
I
I
L
H
R
R
D
A
F
R
A
S
K
T
---
M
Q
E
R
V
L
N
---
H
P
K
I
E
V
I
W
N
S
E
L
V
---
E
L
E
-
G
D
G---
D
L
----
L
-
N
G
A
K
I
H
N
L
-
V
-
S
G
E
Y
K
V
V
P
V
A
G
L
F
Y
A
I
G
H
S
P
N
S
K
F
L
G
-
G
Q
V
K
T
A
D
D
G
Y
I
L
T
E
----
G
------
P
K
T
S
V
D
G
V
F
A
C
G
D
V
C
D
R
V
--
Y
R
Q
A
I
V
A
A
G
S
G
C
M
A
A
L
S
C
E
K
W
L
Q
T
-
H
-----------------
33
PsiBlast_CBE
79.50
43%
-108
- C1 -
4CBQ
8
?
B:
[4-314]
-------------
I
H
D
-
V
V
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
G
R
S
S
L
K
P
V
M
Y
E
G
FMAGG
V
-----
A
-----
A
G
G
Q
L
T
-----
T
T
T
I
I
E
N
F
P
G
F
P
N
G
I
D
G
N
E
L
M
M
N
M
R
T
Q
S
E
K
Y
G
T
T
---
I
I
T
E
T
I
D
H
V
---
D
-------
F
S
T
-
Q
----
P
F
--
K
L
F
T
---
E
E
G
K
E
V
L
T
K
S
V
I
I
A
T
G
A
T
A
K
R
M
H
V
P
G
E
D
K
----
Y
W
Q
----
N
G
V
S
A
C
A
I
C
D
G
--
A
VP
I
F
R
N
K
V
L
M
V
V
G
G
G
D
A
A
M
E
E
A
L
H
L
T
K
Y
G
S
K
V
I
I
L
H
R
R
D
A
F
R
A
S
K
T
---
M
Q
E
R
V
L
N
---
H
P
K
I
E
V
I
W
N
S
E
L
V
---
E
L
E
-
G
D
G---
D
L
----
L
-
N
G
A
K
I
H
N
L
-
V
-
S
G
E
Y
K
V
V
P
V
A
G
L
F
Y
A
I
G
H
S
P
N
S
K
F
L
G
-
G
Q
V
K
T
A
D
D
G
Y
I
L
T
E
----
G
------
P
K
T
S
V
D
G
V
F
A
C
G
D
V
C
D
R
V
--
Y
R
Q
A
I
V
A
A
G
S
G
C
M
A
A
L
S
C
E
K
W
L
Q
T
-
H
-----------------
10
PsiBlast_PDB
79.28
43%
-108
- C1 -
4A5L
4
?
A:
[4-314]
-------------
I
H
D
-
V
V
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
G
R
S
S
L
K
P
V
M
Y
E
G
FMAGG
V
-----
A
-----
A
G
G
Q
L
T
-----
T
T
T
I
I
E
N
F
P
G
F
P
N
G
I
D
G
N
E
L
M
M
N
M
R
T
Q
S
E
K
Y
G
T
T
---
I
I
T
E
T
I
D
H
V
---
D
-------
F
S
T
-
Q
----
P
F
--
K
L
F
T
---
E
E
G
K
E
V
L
T
K
S
V
I
I
A
T
G
A
T
A
K
R
M
H
V
P
G
E
D
K
----
Y
W
Q
----
N
G
V
S
A
C
A
I
C
D
G
--
A
VP
I
F
R
N
K
V
L
M
V
V
G
G
G
D
A
A
M
E
E
A
L
H
L
T
K
Y
G
S
K
V
I
I
L
H
R
R
D
A
F
R
A
S
K
T
---
M
Q
E
R
V
L
N
---
H
P
K
I
E
V
I
W
N
S
E
L
V
---
E
L
E
-
G
D
G---
D
L
----
L
-
N
G
A
K
I
H
N
L
-
V
-
S
G
E
Y
K
V
V
P
V
A
G
L
F
Y
A
I
G
H
S
P
N
S
K
F
L
G
-
G
Q
V
K
T
A
D
D
G
Y
I
L
T
E
----
G
------
P
K
T
S
V
D
G
V
F
A
C
G
D
V
C
D
R
V
--
Y
R
Q
A
I
V
A
A
G
S
G
C
M
A
A
L
S
C
E
K
W
L
Q
T
-
H
-----------------
32
PsiBlast_CBE
79.02
43%
-106
- C1 -
4CCQ
5
?
B:
[4-314]
-------------
I
H
D
-
V
V
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
G
R
S
S
L
K
P
V
M
Y
E
G
FMAGG
V
-----
A
-----
A
G
G
Q
L
T
-----
T
T
T
I
I
E
N
F
P
G
F
P
N
G
I
D
G
N
E
L
M
M
N
M
R
T
Q
S
E
K
Y
G
T
T
---
I
I
T
E
T
I
D
H
V
---
D
-------
F
S
T
-
Q
----
P
F
--
K
L
F
T
---
E
E
G
K
E
V
L
T
K
S
V
I
I
A
T
G
A
T
A
K
R
M
H
V
P
G
E
D
K
----
Y
W
Q
----
N
G
V
S
A
C
A
I
C
D
G
--
A
VP
I
F
R
N
K
V
L
M
V
V
G
G
G
D
A
A
M
E
E
A
L
H
L
T
K
Y
G
S
K
V
I
I
L
H
R
R
D
A
F
R
A
S
K
T
---
M
Q
E
R
V
L
N
---
H
P
K
I
E
V
I
W
N
S
E
L
V
---
E
L
E
-
G
D
G---
D
L
----
L
-
N
G
A
K
I
H
N
L
-
V
-
S
G
E
Y
K
V
V
P
V
A
G
L
F
Y
A
I
G
H
S
P
N
S
K
F
L
G
-
G
Q
V
K
T
A
D
D
G
Y
I
L
T
E
----
G
------
P
K
T
S
V
D
G
V
F
A
C
G
D
V
C
D
R
V
--
Y
R
Q
A
I
V
A
A
G
S
G
C
M
A
A
L
S
C
E
K
W
L
Q
T
-
H
-----------------
17
PsiBlast_PDB
78.95
43%
-108
- C1 -
4UP3
4
?
A:
[4-314]
-------------
I
H
D
-
V
V
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
G
R
S
S
L
K
P
V
M
Y
E
G
FMAGG
V
-----
A
-----
A
G
G
Q
L
T
-----
T
T
T
I
I
E
N
F
P
G
F
P
N
G
I
D
G
N
E
L
M
M
N
M
R
T
Q
S
E
K
Y
G
T
T
---
I
I
T
E
T
I
D
H
V
---
D
-------
F
S
T
-
Q
----
P
F
--
K
L
F
T
---
E
E
G
K
E
V
L
T
K
S
V
I
I
A
T
G
A
T
A
K
R
M
H
V
P
G
E
D
K
----
Y
W
Q
----
N
G
V
S
A
S
A
I
C
D
G
--
A
VP
I
F
R
N
K
V
L
M
V
V
G
G
G
D
A
A
M
E
E
A
L
H
L
T
K
Y
G
S
K
V
I
I
L
H
R
R
D
A
F
R
A
S
K
T
---
M
Q
E
R
V
L
N
---
H
P
K
I
E
V
I
W
N
S
E
L
V
---
E
L
E
-
G
D
G---
D
L
----
L
-
N
G
A
K
I
H
N
L
-
V
-
S
G
E
Y
K
V
V
P
V
A
G
L
F
Y
A
I
G
H
S
P
N
S
K
F
L
G
-
G
Q
V
K
T
A
D
D
G
Y
I
L
T
E
----
G
------
P
K
T
S
V
D
G
V
F
A
C
G
D
V
Q
D
R
V
--
Y
R
Q
A
I
V
A
A
G
S
G
C
M
A
A
L
S
C
E
K
W
L
Q
T
-
H
-----------------
13
PsiBlast_PDB
78.71
43%
-107
- C1 -
4CCQ
6
?
A:
[4-314]
-------------
I
H
D
-
V
V
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
G
R
S
S
L
K
P
V
M
Y
E
G
FMAGG
V
-----
A
-----
A
G
G
Q
L
T
-----
T
T
T
I
I
E
N
F
P
G
F
P
N
G
I
D
G
N
E
L
M
M
N
M
R
T
Q
S
E
K
Y
G
T
T
---
I
I
T
E
T
I
D
H
V
---
D
-------
F
S
T
-
Q
----
P
F
--
K
L
F
T
---
E
E
G
K
E
V
L
T
K
S
V
I
I
A
T
G
A
T
A
K
R
M
H
V
P
G
E
D
K
----
Y
W
Q
----
N
G
V
S
A
C
A
I
C
D
G
--
A
VP
I
F
R
N
K
V
L
M
V
V
G
G
G
D
A
A
M
E
E
A
L
H
L
T
K
Y
G
S
K
V
I
I
L
H
R
R
D
A
F
R
A
S
K
T
---
M
Q
E
R
V
L
N
---
H
P
K
I
E
V
I
W
N
S
E
L
V
---
E
L
E
-
G
D
G---
D
L
----
L
-
N
G
A
K
I
H
N
L
-
V
-
S
G
E
Y
K
V
V
P
V
A
G
L
F
Y
A
I
G
H
S
P
N
S
K
F
L
G
-
G
Q
V
K
T
A
D
D
G
Y
I
L
T
E
----
G
------
P
K
T
S
V
D
G
V
F
A
C
G
D
V
C
D
R
V
--
Y
R
Q
A
I
V
A
A
G
S
G
C
M
A
A
L
S
C
E
K
W
L
Q
T
-
H
-----------------
11
PsiBlast_PDB
78.09
43%
-105
- C1 -
4A65
4
?
A:
[4-314]
-------------
I
H
D
-
V
V
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
G
R
S
S
L
K
P
V
M
Y
E
G
FMAGG
V
-----
A
-----
A
G
G
Q
L
T
-----
T
T
T
I
I
E
N
F
P
G
F
P
N
G
I
D
G
N
E
L
M
M
N
M
R
T
Q
S
E
K
Y
G
T
T
---
I
I
T
E
T
I
D
H
V
---
D
-------
F
S
T
-
Q
----
P
F
--
K
L
F
T
---
E
E
G
K
E
V
L
T
K
S
V
I
I
A
T
G
A
T
A
K
R
M
H
V
P
G
E
D
K
----
Y
W
Q
----
N
G
V
S
A
C
A
I
C
D
G
--
A
VP
I
F
R
N
K
V
L
M
V
V
G
G
G
D
A
A
M
E
E
A
L
H
L
T
K
Y
G
S
K
V
I
I
L
H
R
R
D
A
F
R
A
S
K
T
---
M
Q
E
R
V
L
N
---
H
P
K
I
E
V
I
W
N
S
E
L
V
---
E
L
E
-
G
D
G---
D
L
----
L
-
N
G
A
K
I
H
N
L
-
V
-
S
G
E
Y
K
V
V
P
V
A
G
L
F
Y
A
I
G
H
S
P
N
S
K
F
L
G
-
G
Q
V
K
T
A
D
D
G
Y
I
L
T
E
----
G
------
P
K
T
S
V
D
G
V
F
A
C
G
D
V
C
D
R
V
--
Y
R
Q
A
I
V
A
A
G
S
G
C
M
A
A
L
S
C
E
K
W
L
Q
T
-
H
-----------------
82
HHSearch
77.99
48%
-110
- C1 -
1TRB
1
TRXB_ECOLI
A:
[3-316]
-----------
T
K
H
S
K
-
L
L
I
L
G
S
G
P
A
G
Y
T
A
A
V
Y
A
A
R
A
N
L
Q
P
V
L
I
T
G
-----
M
-----
E
-----
K
G
G
Q
L
T
-----
T
T
T
E
V
E
N
W
P
G
D
P
N
D
L
T
G
P
L
L
M
E
R
M
H
E
H
A
T
K
F
E
T
E
---
I
I
F
D
H
I
N
K
V
---
D
-------
L
Q
N
-
R
----
P
F
--
R
L
N
G
----
D
N
G
E
Y
T
C
D
A
L
I
I
A
T
G
A
S
A
R
Y
L
G
L
P
S
E
E
A
----
F
K
G
----
R
G
V
S
A
C
A
T
S
D
G
--
F
--
F
Y
R
N
Q
K
V
A
V
I
G
G
G
N
T
A
V
E
E
A
L
Y
L
S
N
I
A
S
E
V
H
L
I
H
R
R
D
G
F
R
A
E
K
I
L
I
K
R
L
M
D
K
V
E
---
N
G
N
I
I
L
H
T
N
R
T
L
E
---
E
V
T
-
G
D
----
Q
M
G---
V
-
T
G
V
R
L
R
D
T
-
Q
N
S
D
N
I
E
S
L
D
V
A
G
L
F
V
A
I
G
H
S
P
N
T
A
I
F
E
-
G
Q
L
E
L
-
E
N
G
Y
I
K
V
Q
----
S
G
IHGN
A
T
Q
T
S
I
P
G
V
F
A
A
G
D
V
M
D
H
I
--
Y
R
Q
A
I
T
S
A
G
T
G
C
M
A
A
L
D
A
E
R
Y
L
D
G
-
L
-----------------
74
HHSearch
77.37
44%
-110
- C1 -
4UP3
4
?
A:
[3-313]
------------
N
I
H
D
-
V
V
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
G
R
S
S
L
K
P
V
M
Y
E
G
-----
F
-----
M
-----
A
G
G
V
A
A
GG
Q
L
T
T
T
T
I
I
E
N
F
P
G
F
P
N
G
I
D
G
N
E
L
M
M
N
M
R
T
Q
S
E
K
Y
G
T
T
---
I
I
T
E
T
I
D
H
V
---
D
-------
F
S
T
-
Q
----
P
F
--
K
L
F
T
---
E
E
G
K
E
V
L
T
K
S
V
I
I
A
T
G
A
T
A
K
R
M
H
V
P
G
E
D
K
----
Y
W
Q
----
N
G
V
S
A
S
A
I
C
D
G
--
A
VP
I
F
R
N
K
V
L
M
V
V
G
G
G
D
A
A
M
E
E
A
L
H
L
T
K
Y
G
S
K
V
I
I
L
H
R
R
D
A
F
R
A
S
K
T
---
M
Q
E
R
V
L
N
---
H
P
K
I
E
V
I
W
N
S
E
L
V
---
E
L
E
-
G
D
----
G
D
L---
L
-
N
G
A
K
I
H
N
L
-
V
-
S
G
E
Y
K
V
V
P
V
A
G
L
F
Y
A
I
G
H
S
P
N
S
K
F
L
G
-
G
Q
V
K
T
A
D
D
G
Y
I
L
T
E
----------
G
P
K
T
S
V
D
G
V
F
A
C
G
D
V
Q
D
R
V
--
Y
R
Q
A
I
V
A
A
G
S
G
C
M
A
A
L
S
C
E
K
W
L
Q
T
-------------------
22
PsiBlast_CBE
77.20
46%
-103
- C1 -
3ITJ
2
TRXB1_YEAST
D:
[21-334]
------------
V
H
N
K
-
V
T
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
A
R
A
E
I
K
P
I
L
Y
E
G
MMANG
I
-----
A
-----
A
G
G
Q
L
T
-----
T
T
T
E
I
E
N
F
P
G
F
P
D
G
L
T
G
S
E
L
M
D
R
M
R
E
Q
S
T
K
F
G
T
E
---
I
I
T
E
T
V
S
K
V
---
D
-------
L
S
S
K
P
----
F
K
L
W
T
E
F
N
---
E
D
A
E
P
V
T
T
D
A
I
I
L
A
T
G
A
S
A
K
R
M
H
L
P
G
E
E
T
----
Y
W
Q
----
K
G
I
S
A
C
A
V
C
D
G
--
A
VP
I
F
R
N
K
P
L
A
V
I
G
G
G
D
S
A
C
E
E
A
Q
F
L
T
K
Y
G
S
K
V
F
M
L
V
R
K
D
H
L
R
A
---------
R
A
E
K
---
N
E
K
I
E
I
L
Y
N
T
V
A
L
---
E
A
K
-
G
-----------
L
-
N
A
L
R
I
K
N
T
-
K
-
K
N
E
E
T
D
L
P
V
S
G
L
F
Y
A
I
G
H
T
P
A
T
K
I
V
A
-
G
Q
V
D
T
D
E
A
G
Y
I
K
T
V
----
P
G
----
S
S
L
T
S
V
P
G
F
F
A
A
G
D
V
Q
D
S
K
--
Y
R
Q
A
I
T
S
A
G
S
G
C
M
A
A
L
D
A
E
K
Y
L
---------------------
55
PsiBlast_CBE
76.80
36%
-110
- C1 -
3F8D
5
?
B:
[17-319]
---------------
D
-
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
-
G
-----
E
-----
T
-----
P
G
G
Q
L
T
-----
E
A
G
I
V
D
D
Y
L
G
L
I
E
-
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
---
V
L
L
D
I
V
E
K
I
---
E
-------
N
R
--
D
----
E
F
--
V
V
K
T
---
K
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
----
F
A
G
----
R
G
I
S
Y
C
S
V
A
D
A
--
P
--
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
---
Y
V
E
T
V
K
K
---
K
P
N
V
E
F
V
L
N
S
V
V
K
---
E
I
K
-
G
D
----
K
V
----
V
-
K
Q
V
V
V
E
N
L
-
K
-
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
-----
E
----
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
W
LG
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
T
E
-
K
-----------------
19
PsiBlast_PDB
76.45
46%
-104
- C1 -
4GCM
6
TRXB_STAAW
A:
[8-307]
---------------
D
-
I
A
I
I
G
A
G
P
A
G
M
T
A
A
V
Y
A
S
R
A
N
L
K
T
V
M
I
E
R
-----
G
-----
I
-----
P
G
G
Q
M
A
-----
N
T
E
E
V
E
N
F
P
G
F
E
M
-
I
T
G
P
D
L
S
T
K
M
F
E
H
A
K
K
F
G
A
V
---
Y
Q
Y
G
D
I
K
S
V
---
E
-------
D
K
G
-
E
----
Y
K
---
V
I
N
---
F
G
N
K
E
L
T
A
K
A
V
I
I
A
T
G
A
E
Y
K
K
I
G
V
P
G
E
Q
E
----
L
G
G
----
R
G
V
S
Y
C
A
V
C
D
G
--
A
--
F
F
K
N
K
R
L
F
V
I
G
G
G
D
S
A
V
E
E
G
T
F
L
T
K
F
A
D
K
V
T
I
V
H
R
R
D
E
L
R
A
Q
R
I
---
L
Q
D
R
A
F
K
---
N
D
K
I
D
F
I
W
S
H
T
L
K
---
S
I
N
E
K
D
----
G
K
----
V
-
G
S
V
T
L
T
S
T
-
K
-
D
G
S
E
E
T
H
E
A
D
G
V
F
I
Y
I
G
M
K
P
L
T
A
P
F
K
-
D
L
G
I
T
N
D
V
G
Y
I
V
T
K
----
D
D
----
M
T
-
T
S
V
P
G
I
F
A
A
G
D
V
R
D
K
G
--
L
R
Q
I
V
T
A
T
G
D
G
S
I
A
A
Q
S
A
A
E
Y
I
-
E
-
H
-----------------
51
PsiBlast_CBE
76.21
37%
-108
- C1 -
3F8P
4
?
B:
[17-319]
---------------
D
-
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
-
G
-----
E
-----
T
-----
P
G
G
Q
L
T
-----
E
A
G
I
V
D
D
Y
L
G
L
I
E
-
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
---
V
L
L
D
I
V
E
K
I
---
E
----------------
E
F
--
V
V
K
T
---
K
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
----
F
A
G
----
R
G
I
S
Y
C
S
V
C
D
A
--
P
--
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
---
Y
V
E
T
V
K
K
---
K
P
N
V
E
F
V
L
N
S
V
V
K
---
E
I
K
-
G
D
----
K
V
----
V
-
K
Q
V
V
V
E
N
L
-
K
-
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
-----
E
----
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
W
LG
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
T
E
-
K
-----------------
48
PsiBlast_CBE
75.29
37%
-107
- C1 -
3F8R
3
?
A:
[17-319]
---------------
D
-
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
-
G
-----
E
-----
T
-----
P
G
G
Q
L
T
-----
E
A
G
I
V
D
D
Y
L
G
L
I
E
-
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
---
V
L
L
D
I
V
E
K
I
---
E
-------
N
R
-------
E
F
--
V
V
K
T
---
K
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
----
F
A
G
----
R
G
I
S
Y
C
S
V
C
D
A
--
P
--
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
---
Y
V
E
T
V
K
K
---
K
P
N
V
E
F
V
L
N
S
V
V
K
---
E
I
K
-
G
D
----
K
V
----
V
-
K
Q
V
V
V
E
N
L
-
K
-
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
-----
E
----
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
W
LG
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
T
E
-
K
-----------------
77
HHSearch
75.18
45%
-101
- C1 -
4GCM
6
TRXB_STAAW
A:
[4-310]
-----------
E
I
D
F
D
-
I
A
I
I
G
A
G
P
A
G
M
T
A
A
V
Y
A
S
R
A
N
L
K
T
V
M
I
E
R
-----
G
-----
I
-----
P
G
G
Q
M
A
-----
N
T
E
E
V
E
N
F
P
G
F
E
-
M
I
T
G
P
D
L
S
T
K
M
F
E
H
A
K
K
F
G
A
V
---
Y
Q
Y
G
D
I
K
S
V
---
E
-------
D
K
--
G
----
E
Y
--
K
V
I
N
---
F
G
N
K
E
L
T
A
K
A
V
I
I
A
T
G
A
E
Y
K
K
I
G
V
P
G
E
Q
E
----
L
G
G
----
R
G
V
S
Y
C
A
V
C
D
G
--
A
--
F
F
K
N
K
R
L
F
V
I
G
G
G
D
S
A
V
E
E
G
T
F
L
T
K
F
A
D
K
V
T
I
V
H
R
R
D
E
L
R
A
Q
R
I
---
L
Q
D
R
A
F
K
---
N
D
K
I
D
F
I
W
S
H
T
L
K
---
S
I
N
-
E
K
----
D
G
K---
V
-
G
S
V
T
L
T
S
T
-
K
-
D
G
S
E
E
T
H
E
A
D
G
V
F
I
Y
I
G
M
K
P
L
T
A
P
F
K
D
L
G
I
T
-
N
D
V
G
Y
I
V
T
K
----
D
-----
D
M
T
T
S
V
P
G
I
F
A
A
G
D
V
R
D
K
G
--
L
R
Q
I
V
T
A
T
G
D
G
S
I
A
A
Q
S
A
A
E
Y
I
E
H
-
L
N
D
---------------
47
PsiBlast_CBE
74.92
37%
-106
- C1 -
3F8R
3
?
B:
[17-319]
---------------
D
-
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
-
G
-----
E
-----
T
-----
P
G
G
Q
L
T
-----
E
A
G
I
V
D
D
Y
L
G
L
I
E
-
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
---
V
L
L
D
I
V
E
K
I
---
E
-------
N
R
--
D
----
E
F
--
V
V
K
T
---
K
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
----
F
A
G
----
R
G
I
S
Y
C
S
V
C
D
A
--
P
--
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
---
Y
V
E
T
V
K
K
---
K
P
N
V
E
F
V
L
N
S
V
V
K
---
E
I
K
-
G
D
----
K
V
----
V
-
K
Q
V
V
V
E
N
L
-
K
-
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
-----
E
----
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
W
LG
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
T
E
-
K
-----------------
46
PsiBlast_CBE
74.81
37%
-106
- C1 -
3F8R
3
?
C:
[17-319]
---------------
D
-
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
-
G
-----
E
-----
T
-----
P
G
G
Q
L
T
-----
E
A
G
I
V
D
D
Y
L
G
L
I
E
-
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
---
V
L
L
D
I
V
E
K
I
---
E
-------
N
--------
E
F
--
V
V
K
T
---
K
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
----
F
A
G
----
R
G
I
S
Y
C
S
V
C
D
A
--
P
--
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
---
Y
V
E
T
V
K
K
---
K
P
N
V
E
F
V
L
N
S
V
V
K
---
E
I
K
-
G
D
----
K
V
----
V
-
K
Q
V
V
V
E
N
L
-
K
-
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
-----
E
----
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
W
LG
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
T
E
-
K
-----------------
45
PsiBlast_CBE
73.86
37%
-108
- C1 -
3F8R
3
?
D:
[17-318]
---------------
D
-
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
-
G
-----
E
-----
T
-----
P
G
G
Q
L
T
-----
E
A
G
I
V
D
D
Y
L
G
L
I
E
-
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
---
V
L
L
D
I
V
E
K
I
---
E
-------
N
R
G
-
D
----
E
F
--
V
V
K
T
---
K
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
----
F
A
G
----
R
G
I
S
Y
C
S
V
C
D
A
--
P
--
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
---
Y
V
E
T
V
K
K
---
K
P
N
V
E
F
V
L
N
S
V
V
K
---
E
I
K
-
G
D
----
K
V
----
V
-
K
Q
V
V
V
E
N
L
-
K
---------
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
-----
E
----
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
A
W
LG
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
T
E
-------------------
62
PsiBlast_CBE
69.17
33%
-100
- C1 -
4O5Q
20
AHPF_ECOLI
A:
[214-515]
---------------
D
-
V
L
I
V
G
S
G
P
A
G
A
A
A
A
I
Y
S
A
R
K
G
I
R
T
G
L
M
-
G
-----
E
-----
R
-----
F
G
G
Q
I
L
-----
D
T
V
D
I
E
N
Y
------
I
S
V
P
K
T
E
G
Q
K
L
A
G
A
L
K
V
H
V
D
E
YD
V
D
V
I
D
S
Q
S
A
---
S
K
L
I
P
AA-
V
E
G
-
G
----
L
H
--
Q
I
E
T
---
A
S
G
A
V
L
K
A
R
S
I
I
V
A
T
G
A
K
W
R
N
M
N
V
P
G
E
D
Q
----
Y
R
T
----
K
G
V
T
Y
C
P
H
C
D
G
--
P
--
L
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
Q
V
---
L
Q
D
K
L
R
S
---
L
K
N
V
D
I
I
L
N
A
Q
T
T
---
E
V
K
-
G
D
G---
S
K
----
V
-
V
G
L
E
Y
R
D
R
-
V
-
S
G
D
I
H
N
I
E
L
A
G
I
F
V
Q
I
G
L
L
P
N
T
N
W
L
E
-
G
A
V
E
R
N
R
M
G
E
I
I
I
D
----
A
K
-----
C
E
T
N
V
K
G
V
F
A
A
G
D
C
T
T
V
P
--
Y
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
---------------------
65
PsiBlast_CBE
68.96
33%
-100
- C1 -
4YKG
18
AHPF_ECOLI
A:
[214-515]
---------------
D
-
V
L
I
V
G
S
G
P
A
G
A
A
A
A
I
Y
S
A
R
K
G
I
R
T
G
L
M
-
G
-----
E
-----
R
-----
F
G
G
Q
I
L
-----
D
T
V
D
I
E
N
Y
------
I
S
V
P
K
T
E
G
Q
K
L
A
G
A
L
K
V
H
V
D
EYD
V
D
V
I
D
S
Q
S
A
---
S
K
L
I
P
AA-
V
E
G
-
G
----
L
H
--
Q
I
E
T
---
A
S
G
A
V
L
K
A
R
S
I
I
V
A
T
G
A
K
W
R
N
M
N
V
P
G
E
D
Q
----
Y
R
T
----
K
G
V
T
Y
-
P
H
C
D
G
--
P
--
L
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
Q
V
---
L
Q
D
K
L
R
S
---
L
K
N
V
D
I
I
L
N
A
Q
T
T
---
E
V
K
-
G
D
G---
S
K
----
V
-
V
G
L
E
Y
R
D
R
-
V
-
S
G
D
I
H
N
I
E
L
A
G
I
F
V
Q
I
G
L
L
P
N
T
N
W
L
E
-
G
A
V
E
R
N
R
M
G
E
I
I
I
D
----
A
K
-----
C
E
T
N
V
K
G
V
F
A
A
G
D
C
T
T
V
P
--
Y
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
---------------------
29
PsiBlast_CBE
56.19
43%
-93
- C1 -
4CCR
3
?
D:
[4-314]
-------------
I
H
D
-
V
V
I
I
G
S
G
P
A
A
H
T
A
A
I
Y
L
G
R
S
S
L
K
P
V
M
Y
E
G
FMAGG
V
-----
A
-----
A
G
G
Q
L
T
-----
T
T
T
I
I
E
N
F
P
G
F
P
N
G
I
D
G
N
E
L
M
M
N
M
R
T
Q
S
E
K
Y
G
T
T
---
I
I
T
E
T
I
D
H
V
---
D
-------
F
S
T
-
Q
----
P
F
--
K
L
F
T
---
E
E
G
K
E
V
L
T
K
S
V
I
I
A
T
G
A
T
A
K
--------------------------------------------------------------------------------------------------------------------------------------------------------
A
I
G
H
S
P
N
S
K
F
L
G
-
G
Q
V
K
T
A
D
D
G
Y
I
L
T
E
----
G
------
P
K
T
S
V
D
G
V
F
A
C
G
D
V
C
D
R
V
--
Y
R
Q
A
I
V
A
A
G
S
G
C
M
A
A
L
S
C
E
K
W
L
Q
T
-
H
-----------------