@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0002: (2015-12-17 )
MHFTIQREALLKPLQLVAGVVERRQTLPVLSNVLLVVEGQQLSLTGTDLEVELVGRVVLEDAAEPGEITVPARKLMDICKSLPNDVLIDIRVEEQKLLVKAGRSRFTLSTLPANDFPTVEEGPGSLNFSIAQSKLRRLIDRTSFAMAQQDVRYYLNGMLLEVNGGTLRSVATDGHRLAMCSLDAQIPSQDRHQVIVPRKGILELARLLTEQDGEVGIVLGQHHIRATTGEFTFTSKLVDGKFPDYERVLPRGGDKLVVGDRQQLREAFSRTAILSNEKYRGIRLQLSNGLLKIQANNPEQEEAEEEVQVEYNGGNLEIGFNVSYLLDVLGVIGTEQVRFILSDSNSSALVHEADNDDSAYVVMPMRL
Atome Classification :
(60 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.--......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
H
F
T
I
Q
R
E
A
L
L
K
P
L
Q
L
V
A
G
V
V
E
R
R
Q
T
L
P
V
L
S
N
V
L
L
V
V
EG
Q
Q
L
S
LTGT
D
L
E
V
E
L
V
G
R
V
V
L
EDAAEPG
E
I
T
V
P
A
R
K
L
M
D
I
C
K
SLPN
D
V
L
I
D
I
R
V
E
E
Q
K
L
L
V
K
AGRS
R
F
T
L
STLPANDFPTVEEGPGSL
N
F
S
I
A
Q
S
K
L
R
R
L
I
D
R
T
S
F
A
M
A
Q
Q
D
V
R
Y
Y
LN
G
M
L
L
E
VNGG
T
L
R
S
VATDG
H
R
L
A
M
C
S
LD--AQIPSQDR
H
Q
V
IVP
R
K
G
I
L
E
L
A
R
L
L
T
EQDG
E
V
G
I
V
L
GQ
H
H
I
R
ATTG
E
F
T
F
T
SKLVDGKFP
D
Y
E
R
VLPRGG
D
K
L
V
VG
D
R
Q
Q
L
R
E
A
F
S
R
T
AILSNEKY
R
G
I
R
L
Q
LSN
G
L
L
K
I
QANNP
E
Q
E
E
AEE
E
V
Q
V
E
YNGG
N
L
E
I
GF
N
V
S
Y
L
L
D
V
L
G
VIGT
E
Q
V
R
F
I
L
SDSNS
S
A
L
V
H
EADNDD
S
A
Y
V
V
M
P
MRL
24
PsiBlast_CBE
96.96
100%
-135
- C5 -
4TSZ
1
?
M:
[2-368]
M
H
F
T
I
Q
R
E
A
L
L
K
P
L
Q
L
V
A
G
V
V
E
--
Q
T
L
P
V
L
S
N
V
L
L
V
V
E
G
Q
Q
L
S
L
T
G
T
D
L
E
V
E
L
V
G
R
V
V
L
E
D
A
A
E
P
G
E
I
T
V
P
A
R
K
L
M
D
I
C
K
S
L
P
N
D
V
L
I
D
I
R
V
E
E
Q
K
L
L
V
K
A
G
R
S
R
F
T
L
S
T
L
P
A
N
D
F
P
---
E
G
P
G
S
L
N
F
S
I
A
Q
S
K
L
R
R
L
I
D
R
T
S
F
A
M
A
Q
Q
D
V
R
Y
Y
L
N
G
M
L
L
E
V
N
G
G
T
L
R
S
V
A
T
D
G
H
R
L
A
M
C
S
L
D
--
A
Q
I
P
S
Q
D
R
H
Q
V
I
V
P
R
K
G
I
L
E
L
A
R
L
L
T
E
Q
D
G
E
V
G
I
V
L
G
Q
H
H
I
R
A
T
T
G
E
F
T
F
T
S
K
L
V
D
G
K
F
P
D
Y
E
R
V
L
P
R
G
G
D
K
L
V
V
G
D
R
Q
Q
L
R
E
A
F
S
R
T
A
I
L
S
N
E
K
Y
R
G
I
R
L
Q
L
S
N
G
L
L
K
I
Q
A
N
N
P
E
Q
E
E
A
E
E
E
V
Q
V
E
Y
N
G
G
N
L
E
I
G
F
N
V
S
Y
L
L
D
V
L
G
V
I
G
T
E
Q
V
R
F
I
L
S
D
S
N
S
S
A
L
V
H
E
A
D
N
D
D
S
A
Y
V
V
M
P
M
R
L
32
PsiBlast_CBE
96.83
100%
-136
- C5 -
4TSZ
1
?
D:
[2-368]
M
H
F
T
I
Q
R
E
A
L
L
K
P
L
Q
L
V
A
G
V
V
E
--
Q
T
L
P
V
L
S
N
V
L
L
V
V
E
G
Q
Q
L
S
L
T
G
T
D
L
E
V
E
L
V
G
R
V
V
L
E
D
A
A
E
P
G
E
I
T
V
P
A
R
K
L
M
D
I
C
K
S
L
P
N
D
V
L
I
D
I
R
V
E
E
Q
K
L
L
V
K
A
G
R
S
R
F
T
L
S
T
L
P
A
N
D
F
P
---
E
G
P
G
S
L
N
F
S
I
A
Q
S
K
L
R
R
L
I
D
R
T
S
F
A
M
A
Q
Q
D
V
R
Y
Y
L
N
G
M
L
L
E
V
N
G
G
T
L
R
S
V
A
T
D
G
H
R
L
A
M
C
S
L
D
--
A
Q
I
P
S
Q
D
R
H
Q
V
I
V
P
R
K
G
I
L
E
L
A
R
L
L
T
E
Q
D
G
E
V
G
I
V
L
G
Q
H
H
I
R
A
T
T
G
E
F
T
F
T
S
K
L
V
D
G
K
F
P
D
Y
E
R
V
L
P
R
G
G
D
K
L
V
V
G
D
R
Q
Q
L
R
E
A
F
S
R
T
A
I
L
S
N
E
K
Y
R
G
I
R
L
Q
L
S
N
G
L
L
K
I
Q
A
N
N
P
E
Q
E
E
A
E
E
E
V
Q
V
E
Y
N
G
G
N
L
E
I
G
F
N
V
S
Y
L
L
D
V
L
G
V
I
G
T
E
Q
V
R
F
I
L
S
D
S
N
S
S
A
L
V
H
E
A
D
N
D
D
S
A
Y
V
V
M
P
M
R
L
28
PsiBlast_CBE
96.69
100%
-136
- C5 -
4TSZ
1
?
I:
[2-368]
M
H
F
T
I
Q
R
E
A
L
L
K
P
L
Q
L
V
A
G
V
V
E
--
Q
T
L
P
V
L
S
N
V
L
L
V
V
E
G
Q
Q
L
S
L
T
G
T
D
L
E
V
E
L
V
G
R
V
V
L
E
D
A
A
E
P
G
E
I
T
V
P
A
R
K
L
M
D
I
C
K
S
L
P
N
D
V
L
I
D
I
R
V
E
E
Q
K
L
L
V
K
A
G
R
S
R
F
T
L
S
T
L
P
A
N
D
F
P
T
V
E
E
G
P
G
S
L
N
F
S
I
A
Q
S
K
L
R
R
L
I
D
R
T
S
F
A
M
A
Q
Q
D
V
R
Y
Y
L
N
G
M
L
L
E
V
N
G
G
T
L
R
S
V
A
T
D
G
H
R
L
A
M
C
S
L
D
--
A
Q
I
P
S
Q
D
R
H
Q
V
I
V
P
R
K
G
I
L
E
L
A
R
L
L
T
E
Q
D
G
E
V
G
I
V
L
G
Q
H
H
I
R
A
T
T
G
E
F
T
F
T
S
K
L
V
D
G
K
F
P
D
Y
E
R
V
L
P
R
G
G
D
K
L
V
V
G
D
R
Q
Q
L
R
E
A
F
S
R
T
A
I
L
S
N
E
K
Y
R
G
I
R
L
Q
L
S
N
G
L
L
K
I
Q
A
N
N
P
E
Q
E
E
A
E
E
E
V
Q
V
E
Y
N
G
G
N
L
E
I
G
F
N
V
S
Y
L
L
D
V
L
G
V
I
G
T
E
Q
V
R
F
I
L
S
D
S
N
S
S
A
L
V
H
E
A
D
N
D
D
S
A
Y
V
V
M
P
M
R
L
31
PsiBlast_CBE
96.68
100%
-136
- C5 -
4TSZ
1
?
E:
[2-368]
M
H
F
T
I
Q
R
E
A
L
L
K
P
L
Q
L
V
A
G
V
V
E
--
Q
T
L
P
V
L
S
N
V
L
L
V
V
E
G
Q
Q
L
S
L
T
G
T
D
L
E
V
E
L
V
G
R
V
V
L
E
D
A
A
E
P
G
E
I
T
V
P
A
R
K
L
M
D
I
C
K
S
L
P
N
D
V
L
I
D
I
R
V
E
E
Q
K
L
L
V
K
A
G
R
S
R
F
T
L
S
T
L
P
A
N
D
F
P
---
E
G
P
G
S
L
N
F
S
I
A
Q
S
K
L
R
R
L
I
D
R
T
S
F
A
M
A
Q
Q
D
V
R
Y
Y
L
N
G
M
L
L
E
V
N
G
G
T
L
R
S
V
A
T
D
G
H
R
L
A
M
C
S
L
D
--
A
Q
I
P
S
Q
D
R
H
Q
V
I
V
P
R
K
G
I
L
E
L
A
R
L
L
T
E
Q
D
G
E
V
G
I
V
L
G
Q
H
H
I
R
A
T
T
G
E
F
T
F
T
S
K
L
V
D
G
K
F
P
D
Y
E
R
V
L
P
R
G
G
D
K
L
V
V
G
D
R
Q
Q
L
R
E
A
F
S
R
T
A
I
L
S
N
E
K
Y
R
G
I
R
L
Q
L
S
N
G
L
L
K
I
Q
A
N
N
P
E
Q
E
E
A
E
E
E
V
Q
V
E
Y
N
G
G
N
L
E
I
G
F
N
V
S
Y
L
L
D
V
L
G
V
I
G
T
E
Q
V
R
F
I
L
S
D
S
N
S
S
A
L
V
H
E
A
D
N
D
D
S
A
Y
V
V
M
P
M
R
L
25
PsiBlast_CBE
96.66
100%
-137
- C5 -
4TSZ
1
?
L:
[2-368]
M
H
F
T
I
Q
R
E
A
L
L
K
P
L
Q
L
V
A
G
V
V
E
--
Q
T
L
P
V
L
S
N
V
L
L
V
V
E
G
Q
Q
L
S
L
T
G
T
D
L
E
V
E
L
V
G
R
V
V
L
E
D
A
A
E
P
G
E
I
T
V
P
A
R
K
L
M
D
I
C
K
S
L
P
N
D
V
L
I
D
I
R
V
E
E
Q
K
L
L
V
K
A
G
R
S
R
F
T
L
S
T
L
P
A
N
D
F
P
---
E
G
P
G
S
L
N
F
S
I
A
Q
S
K
L
R
R
L
I
D
R
T
S
F
A
M
A
Q
Q
D
V
R
Y
Y
L
N
G
M
L
L
E
V
N
G
G
T
L
R
S
V
A
T
D
G
H
R
L
A
M
C
S
L
D
--
A
Q
I
P
S
Q
D
R
H
Q
V
I
V
P
R
K
G
I
L
E
L
A
R
L
L
T
E
Q
D
G
E
V
G
I
V
L
G
Q
H
H
I
R
A
T
T
G
E
F
T
F
T
S
K
L
V
D
G
K
F
P
D
Y
E
R
V
L
P
R
G
G
D
K
L
V
V
G
D
R
Q
Q
L
R
E
A
F
S
R
T
A
I
L
S
N
E
K
Y
R
G
I
R
L
Q
L
S
N
G
L
L
K
I
Q
A
N
N
P
E
Q
E
E
A
E
E
E
V
Q
V
E
Y
N
G
G
N
L
E
I
G
F
N
V
S
Y
L
L
D
V
L
G
V
I
G
T
E
Q
V
R
F
I
L
S
D
S
N
S
S
A
L
V
H
E
A
D
N
D
D
S
A
Y
V
V
M
P
M
R
L
33
PsiBlast_CBE
96.55
100%
-136
- C5 -
4TSZ
1
?
C:
[2-368]
M
H
F
T
I
Q
R
E
A
L
L
K
P
L
Q
L
V
A
G
V
V
E
--
Q
T
L
P
V
L
S
N
V
L
L
V
V
E
G
Q
Q
L
S
L
T
G
T
D
L
E
V
E
L
V
G
R
V
V
L
E
D
A
A
E
P
G
E
I
T
V
P
A
R
K
L
M
D
I
C
K
S
L
P
N
D
V
L
I
D
I
R
V
E
E
Q
K
L
L
V
K
A
G
R
S
R
F
T
L
S
T
L
P
A
N
D
F
P
---
E
G
P
G
S
L
N
F
S
I
A
Q
S
K
L
R
R
L
I
D
R
T
S
F
A
M
A
Q
Q
D
V
R
Y
Y
L
N
G
M
L
L
E
V
N
G
G
T
L
R
S
V
A
T
D
G
H
R
L
A
M
C
S
L
D
--
A
Q
I
P
S
Q
D
R
H
Q
V
I
V
P
R
K
G
I
L
E
L
A
R
L
L
T
E
Q
D
G
E
V
G
I
V
L
G
Q
H
H
I
R
A
T
T
G
E
F
T
F
T
S
K
L
V
D
G
K
F
P
D
Y
E
R
V
L
P
R
G
G
D
K
L
V
V
G
D
R
Q
Q
L
R
E
A
F
S
R
T
A
I
L
S
N
E
K
Y
R
G
I
R
L
Q
L
S
N
G
L
L
K
I
Q
A
N
N
P
E
Q
E
E
A
E
E
E
V
Q
V
E
Y
N
G
G
N
L
E
I
G
F
N
V
S
Y
L
L
D
V
L
G
V
I
G
T
E
Q
V
R
F
I
L
S
D
S
N
S
S
A
L
V
H
E
A
D
N
D
D
S
A
Y
V
V
M
P
M
R
L
34
PsiBlast_CBE
96.49
100%
-136
- C5 -
4TSZ
1
?
B:
[2-368]
M
H
F
T
I
Q
R
E
A
L
L
K
P
L
Q
L
V
A
G
V
V
E
--
Q
T
L
P
V
L
S
N
V
L
L
V
V
E
G
Q
Q
L
S
L
T
G
T
D
L
E
V
E
L
V
G
R
V
V
L
E
D
A
A
E
P
G
E
I
T
V
P
A
R
K
L
M
D
I
C
K
S
L
P
N
D
V
L
I
D
I
R
V
E
E
Q
K
L
L
V
K
A
G
R
S
R
F
T
L
S
T
L
P
A
N
D
F
P
---
E
G
P
G
S
L
N
F
S
I
A
Q
S
K
L
R
R
L
I
D
R
T
S
F
A
M
A
Q
Q
D
V
R
Y
Y
L
N
G
M
L
L
E
V
N
G
G
T
L
R
S
V
A
T
D
G
H
R
L
A
M
C
S
L
D
--
A
Q
I
P
S
Q
D
R
H
Q
V
I
V
P
R
K
G
I
L
E
L
A
R
L
L
T
E
Q
D
G
E
V
G
I
V
L
G
Q
H
H
I
R
A
T
T
G
E
F
T
F
T
S
K
L
V
D
G
K
F
P
D
Y
E
R
V
L
P
R
G
G
D
K
L
V
V
G
D
R
Q
Q
L
R
E
A
F
S
R
T
A
I
L
S
N
E
K
Y
R
G
I
R
L
Q
L
S
N
G
L
L
K
I
Q
A
N
N
P
E
Q
E
E
A
E
E
E
V
Q
V
E
Y
N
G
G
N
L
E
I
G
F
N
V
S
Y
L
L
D
V
L
G
V
I
G
T
E
Q
V
R
F
I
L
S
D
S
N
S
S
A
L
V
H
E
A
D
N
D
D
S
A
Y
V
V
M
P
M
R
L
35
PsiBlast_CBE
96.47
100%
-136
- C5 -
4TSZ
2
?
A:
[2-368]
M
H
F
T
I
Q
R
E
A
L
L
K
P
L
Q
L
V
A
G
V
V
E
--
Q
T
L
P
V
L
S
N
V
L
L
V
V
E
G
Q
Q
L
S
L
T
G
T
D
L
E
V
E
L
V
G
R
V
V
L
E
D
A
A
E
P
G
E
I
T
V
P
A
R
K
L
M
D
I
C
K
S
L
P
N
D
V
L
I
D
I
R
V
E
E
Q
K
L
L
V
K
A
G
R
S
R
F
T
L
S
T
L
P
A
N
D
F
P
---
E
G
P
G
S
L
N
F
S
I
A
Q
S
K
L
R
R
L
I
D
R
T
S
F
A
M
A
Q
Q
D
V
R
Y
Y
L
N
G
M
L
L
E
V
N
G
G
T
L
R
S
V
A
T
D
G
H
R
L
A
M
C
S
L
D
--
A
Q
I
P
S
Q
D
R
H
Q
V
I
V
P
R
K
G
I
L
E
L
A
R
L
L
T
E
Q
D
G
E
V
G
I
V
L
G
Q
H
H
I
R
A
T
T
G
E
F
T
F
T
S
K
L
V
D
G
K
F
P
D
Y
E
R
V
L
P
R
G
G
D
K
L
V
V
G
D
R
Q
Q
L
R
E
A
F
S
R
T
A
I
L
S
N
E
K
Y
R
G
I
R
L
Q
L
S
N
G
L
L
K
I
Q
A
N
N
P
E
Q
E
E
A
E
E
E
V
Q
V
E
Y
N
G
G
N
L
E
I
G
F
N
V
S
Y
L
L
D
V
L
G
V
I
G
T
E
Q
V
R
F
I
L
S
D
S
N
S
S
A
L
V
H
E
A
D
N
D
D
S
A
Y
V
V
M
P
M
R
L
1
PsiBlast_PDB
96.44
100%
-136
- C5 -
4TSZ
1
?
H:
[2-368]
M
H
F
T
I
Q
R
E
A
L
L
K
P
L
Q
L
V
A
G
V
V
E
--
Q
T
L
P
V
L
S
N
V
L
L
V
V
E
G
Q
Q
L
S
L
T
G
T
D
L
E
V
E
L
V
G
R
V
V
L
E
D
A
A
E
P
G
E
I
T
V
P
A
R
K
L
M
D
I
C
K
S
L
P
N
D
V
L
I
D
I
R
V
E
E
Q
K
L
L
V
K
A
G
R
S
R
F
T
L
S
T
L
P
A
N
D
F
P
T
V
E
E
G
P
G
S
L
N
F
S
I
A
Q
S
K
L
R
R
L
I
D
R
T
S
F
A
M
A
Q
Q
D
V
R
Y
Y
L
N
G
M
L
L
E
V
N
G
G
T
L
R
S
V
A
T
D
G
H
R
L
A
M
C
S
L
D
--
A
Q
I
P
S
Q
D
R
H
Q
V
I
V
P
R
K
G
I
L
E
L
A
R
L
L
T
E
Q
D
G
E
V
G
I
V
L
G
Q
H
H
I
R
A
T
T
G
E
F
T
F
T
S
K
L
V
D
G
K
F
P
D
Y
E
R
V
L
P
R
G
G
D
K
L
V
V
G
D
R
Q
Q
L
R
E
A
F
S
R
T
A
I
L
S
N
E
K
Y
R
G
I
R
L
Q
L
S
N
G
L
L
K
I
Q
A
N
N
P
E
Q
E
E
A
E
E
E
V
Q
V
E
Y
N
G
G
N
L
E
I
G
F
N
V
S
Y
L
L
D
V
L
G
V
I
G
T
E
Q
V
R
F
I
L
S
D
S
N
S
S
A
L
V
H
E
A
D
N
D
D
S
A
Y
V
V
M
P
M
R
L
27
PsiBlast_CBE
96.35
100%
-136
- C5 -
4TSZ
1
?
J:
[2-368]
M
H
F
T
I
Q
R
E
A
L
L
K
P
L
Q
L
V
A
G
V
V
E
--
Q
T
L
P
V
L
S
N
V
L
L
V
V
E
G
Q
Q
L
S
L
T
G
T
D
L
E
V
E
L
V
G
R
V
V
L
E
D
A
A
E
P
G
E
I
T
V
P
A
R
K
L
M
D
I
C
K
S
L
P
N
D
V
L
I
D
I
R
V
E
E
Q
K
L
L
V
K
A
G
R
S
R
F
T
L
S
T
L
P
A
N
D
F
P
T
V
E
E
G
P
G
S
L
N
F
S
I
A
Q
S
K
L
R
R
L
I
D
R
T
S
F
A
M
A
Q
Q
D
V
R
Y
Y
L
N
G
M
L
L
E
V
N
G
G
T
L
R
S
V
A
T
D
G
H
R
L
A
M
C
S
L
D
--
A
Q
I
P
S
Q
D
R
H
Q
V
I
V
P
R
K
G
I
L
E
L
A
R
L
L
T
E
Q
D
G
E
V
G
I
V
L
G
Q
H
H
I
R
A
T
T
G
E
F
T
F
T
S
K
L
V
D
G
K
F
P
D
Y
E
R
V
L
P
R
G
G
D
K
L
V
V
G
D
R
Q
Q
L
R
E
A
F
S
R
T
A
I
L
S
N
E
K
Y
R
G
I
R
L
Q
L
S
N
G
L
L
K
I
Q
A
N
N
P
E
Q
E
E
A
E
E
E
V
Q
V
E
Y
N
G
G
N
L
E
I
G
F
N
V
S
Y
L
L
D
V
L
G
V
I
G
T
E
Q
V
R
F
I
L
S
D
S
N
S
S
A
L
V
H
E
A
D
N
D
D
S
A
Y
V
V
M
P
M
R
L
29
PsiBlast_CBE
96.31
100%
-136
- C5 -
4TSZ
1
?
G:
[2-368]
M
H
F
T
I
Q
R
E
A
L
L
K
P
L
Q
L
V
A
G
V
V
E
--
Q
T
L
P
V
L
S
N
V
L
L
V
V
E
G
Q
Q
L
S
L
T
G
T
D
L
E
V
E
L
V
G
R
V
V
L
E
D
A
A
E
P
G
E
I
T
V
P
A
R
K
L
M
D
I
C
K
S
L
P
N
D
V
L
I
D
I
R
V
E
E
Q
K
L
L
V
K
A
G
R
S
R
F
T
L
S
T
L
P
A
N
D
F
P
T
V
E
E
G
P
G
S
L
N
F
S
I
A
Q
S
K
L
R
R
L
I
D
R
T
S
F
A
M
A
Q
Q
D
V
R
Y
Y
L
N
G
M
L
L
E
V
N
G
G
T
L
R
S
V
A
T
D
G
H
R
L
A
M
C
S
L
D
--
A
Q
I
P
S
Q
D
R
H
Q
V
I
V
P
R
K
G
I
L
E
L
A
R
L
L
T
E
Q
D
G
E
V
G
I
V
L
G
Q
H
H
I
R
A
T
T
G
E
F
T
F
T
S
K
L
V
D
G
K
F
P
D
Y
E
R
V
L
P
R
G
G
D
K
L
V
V
G
D
R
Q
Q
L
R
E
A
F
S
R
T
A
I
L
S
N
E
K
Y
R
G
I
R
L
Q
L
S
N
G
L
L
K
I
Q
A
N
N
P
E
Q
E
E
A
E
E
E
V
Q
V
E
Y
N
G
G
N
L
E
I
G
F
N
V
S
Y
L
L
D
V
L
G
V
I
G
T
E
Q
V
R
F
I
L
S
D
S
N
S
S
A
L
V
H
E
A
D
N
D
D
S
A
Y
V
V
M
P
M
R
L
26
PsiBlast_CBE
96.22
100%
-136
- C5 -
4TSZ
1
?
K:
[2-368]
M
H
F
T
I
Q
R
E
A
L
L
K
P
L
Q
L
V
A
G
V
V
E
--
Q
T
L
P
V
L
S
N
V
L
L
V
V
E
G
Q
Q
L
S
L
T
G
T
D
L
E
V
E
L
V
G
R
V
V
L
E
D
A
A
E
P
G
E
I
T
V
P
A
R
K
L
M
D
I
C
K
S
L
P
N
D
V
L
I
D
I
R
V
E
E
Q
K
L
L
V
K
A
G
R
S
R
F
T
L
S
T
L
P
A
N
D
F
P
---
E
G
P
G
S
L
N
F
S
I
A
Q
S
K
L
R
R
L
I
D
R
T
S
F
A
M
A
Q
Q
D
V
R
Y
Y
L
N
G
M
L
L
E
V
N
G
G
T
L
R
S
V
A
T
D
G
H
R
L
A
M
C
S
L
D
--
A
Q
I
P
S
Q
D
R
H
Q
V
I
V
P
R
K
G
I
L
E
L
A
R
L
L
T
E
Q
D
G
E
V
G
I
V
L
G
Q
H
H
I
R
A
T
T
G
E
F
T
F
T
S
K
L
V
D
G
K
F
P
D
Y
E
R
V
L
P
R
G
G
D
K
L
V
V
G
D
R
Q
Q
L
R
E
A
F
S
R
T
A
I
L
S
N
E
K
Y
R
G
I
R
L
Q
L
S
N
G
L
L
K
I
Q
A
N
N
P
E
Q
E
E
A
E
E
E
V
Q
V
E
Y
N
G
G
N
L
E
I
G
F
N
V
S
Y
L
L
D
V
L
G
V
I
G
T
E
Q
V
R
F
I
L
S
D
S
N
S
S
A
L
V
H
E
A
D
N
D
D
S
A
Y
V
V
M
P
M
R
L
30
PsiBlast_CBE
96.15
100%
-135
- C5 -
4TSZ
1
?
F:
[2-368]
M
H
F
T
I
Q
R
E
A
L
L
K
P
L
Q
L
V
A
G
V
V
E
--
Q
T
L
P
V
L
S
N
V
L
L
V
V
E
G
Q
Q
L
S
L
T
G
T
D
L
E
V
E
L
V
G
R
V
V
L
E
D
A
A
E
P
G
E
I
T
V
P
A
R
K
L
M
D
I
C
K
S
L
P
N
D
V
L
I
D
I
R
V
E
E
Q
K
L
L
V
K
A
G
R
S
R
F
T
L
S
T
L
P
A
N
D
F
P
T
V
E
E
G
P
G
S
L
N
F
S
I
A
Q
S
K
L
R
R
L
I
D
R
T
S
F
A
M
A
Q
Q
D
V
R
Y
Y
L
N
G
M
L
L
E
V
N
G
G
T
L
R
S
V
A
T
D
G
H
R
L
A
M
C
S
L
D
--
A
Q
I
P
S
Q
D
R
H
Q
V
I
V
P
R
K
G
I
L
E
L
A
R
L
L
T
E
Q
D
G
E
V
G
I
V
L
G
Q
H
H
I
R
A
T
T
G
E
F
T
F
T
S
K
L
V
D
G
K
F
P
D
Y
E
R
V
L
P
R
G
G
D
K
L
V
V
G
D
R
Q
Q
L
R
E
A
F
S
R
T
A
I
L
S
N
E
K
Y
R
G
I
R
L
Q
L
S
N
G
L
L
K
I
Q
A
N
N
P
E
Q
E
E
A
E
E
E
V
Q
V
E
Y
N
G
G
N
L
E
I
G
F
N
V
S
Y
L
L
D
V
L
G
V
I
G
T
E
Q
V
R
F
I
L
S
D
S
N
S
S
A
L
V
H
E
A
D
N
D
D
S
A
Y
V
V
M
P
M
R
L
2
PsiBlast_PDB
95.46
100%
-135
- C5 -
4TR8
1
?
A:
[17-382]
M
H
F
T
I
Q
R
E
A
L
L
K
P
L
Q
L
V
A
G
V
V
E
---
T
L
P
V
L
S
N
V
L
L
V
V
E
G
Q
Q
L
S
L
T
G
T
D
L
E
V
E
L
V
G
R
V
V
L
E
D
A
A
E
P
G
E
I
T
V
P
A
R
K
L
M
D
I
C
K
S
L
P
N
D
V
L
I
D
I
R
V
E
E
Q
K
L
L
V
K
A
G
R
S
R
F
T
L
S
T
L
P
A
N
D
F
P
T
V
E
E
G
P
G
S
L
N
F
S
I
A
Q
S
K
L
R
R
L
I
D
R
T
S
F
A
M
A
Q
Q
D
V
R
Y
Y
L
N
G
M
L
L
E
V
N
G
G
T
L
R
S
V
A
T
D
G
H
R
L
A
M
C
S
L
D
--
A
Q
I
P
S
Q
D
R
H
Q
V
I
V
P
R
K
G
I
L
E
L
A
R
L
L
T
E
Q
D
G
E
V
G
I
V
L
G
Q
H
H
I
R
A
T
T
G
E
F
T
F
T
S
K
L
V
D
G
K
F
P
D
Y
E
R
V
L
P
R
G
G
D
K
L
V
V
G
D
R
Q
Q
L
R
E
A
F
S
R
T
A
I
L
S
N
E
K
Y
R
G
I
R
L
Q
L
S
N
G
L
L
K
I
Q
A
N
N
P
E
Q
E
E
A
E
E
E
V
Q
V
E
Y
N
G
G
N
L
E
I
G
F
N
V
S
Y
L
L
D
V
L
G
V
I
G
T
E
Q
V
R
F
I
L
S
D
S
N
S
S
A
L
V
H
E
A
D
N
D
D
S
A
Y
V
V
M
P
M
R
-
65
PsiBlast_CBE
83.62
55%
-126
- C5 -
4MJQ
8
DPO3B_ECOLI
A:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
----
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
16
PsiBlast_PDB
83.50
55%
-133
- C5 -
4K3L
7
DPO3B_ECOLI
A:
[1-365]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
---------
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
---
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
-
81
PsiBlast_CBE
83.43
55%
-130
- C5 -
3Q4K
1
DPO3B_ECOLI
B:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
------
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
66
PsiBlast_CBE
83.16
55%
-134
- C5 -
4MJP
6
DPO3B_ECOLI
B:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
-------
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
14
PsiBlast_PDB
83.16
55%
-134
- C5 -
3Q4K
1
DPO3B_ECOLI
A:
[1-365]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
-------
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
--
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
-
3
PsiBlast_PDB
83.13
55%
-131
- C5 -
3Q4L
1
DPO3B_ECOLI
A:
[3-368]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
----
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
41
PsiBlast_CBE
82.99
55%
-132
- C5 -
4PNU
5
?
B:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
------
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
48
PsiBlast_CBE
82.90
55%
-130
- C5 -
4OVF
7
?
A:
[1-364]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
----
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
--
53
PsiBlast_CBE
82.83
55%
-133
- C5 -
4N98
6
DPO3B_ECOLI
A:
[1-364]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
------
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
--
46
PsiBlast_CBE
82.79
55%
-128
- C5 -
4OVG
10
?
A:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
-----
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
50
PsiBlast_CBE
82.74
55%
-131
- C5 -
4N9A
7
DPO3B_ECOLI
A:
[1-364]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
--------
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
--
42
PsiBlast_CBE
82.73
55%
-132
- C5 -
4PNU
7
?
A:
[1-364]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
-----
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
--
18
PsiBlast_PDB
82.66
55%
-129
- C5 -
4K3O
9
DPO3B_ECOLI
A:
[1-365]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
-----
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
-
17
PsiBlast_PDB
82.45
55%
-128
- C5 -
4K3M
6
DPO3B_ECOLI
A:
[1-365]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
-------
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
-
36
PsiBlast_CBE
82.40
55%
-128
- C5 -
3Q4L
2
DPO3B_ECOLI
B:
[3-367]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
---
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
-
20
PsiBlast_PDB
82.40
55%
-130
- C5 -
4K3Q
12
DPO3B_ECOLI
A:
[1-365]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
-------
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
-
69
PsiBlast_CBE
82.25
55%
-132
- C5 -
4K74
1
?
A:
[7-370]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
-----
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
---
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
--
83
PsiBlast_CBE
82.23
55%
-131
- C5 -
3Q4J
1
DPO3B_ECOLI
E:
[1-365]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
-
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
-
63
PsiBlast_CBE
82.18
55%
-125
- C5 -
4MJR
4
DPO3B_ECOLI
A:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
------
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
45
PsiBlast_CBE
82.12
55%
-126
- C5 -
4OVG
7
?
B:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
73
PsiBlast_CBE
82.11
55%
-128
- C5 -
4K3R
6
DPO3B_ECOLI
A:
[1-365]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
-------
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
-
84
PsiBlast_CBE
82.09
55%
-127
- C5 -
3Q4J
1
DPO3B_ECOLI
D:
[1-365]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
-
80
PsiBlast_CBE
81.98
55%
-126
- C5 -
3QSB
1
DPO3B_ECOLI
A:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
57
PsiBlast_CBE
81.96
55%
-127
- C5 -
4N96
8
DPO3B_ECOLI
A:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
---------
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
-
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
10
PsiBlast_PDB
81.95
55%
-126
- C5 -
3D1E
1
DPO3B_ECOLI
A:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
78
PsiBlast_CBE
81.93
55%
-128
- C5 -
4K3L
17
DPO3B_ECOLI
B:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
-------
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
86
PsiBlast_CBE
81.92
55%
-128
- C5 -
3Q4J
1
DPO3B_ECOLI
B:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
--
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
I
G
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
15
PsiBlast_PDB
81.83
55%
-126
- C5 -
4K3K
8
DPO3B_ECOLI
A:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
--------
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
68
PsiBlast_CBE
81.82
55%
-129
- C5 -
4K74
1
?
B:
[7-370]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
--
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
--
59
PsiBlast_CBE
81.78
55%
-125
- C5 -
4N95
10
DPO3B_ECOLI
A:
[1-365]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
------
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
-
87
PsiBlast_CBE
81.77
55%
-127
- C5 -
3D1G
1
DPO3B_ECOLI
B:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
62
PsiBlast_CBE
81.70
55%
-126
- C5 -
4MJR
7
DPO3B_ECOLI
B:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
-
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
88
PsiBlast_CBE
81.61
55%
-124
- C5 -
3D1F
2
DPO3B_ECOLI
B:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
55
PsiBlast_CBE
81.50
55%
-122
- C5 -
4N97
6
DPO3B_ECOLI
A:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
-----
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
82
PsiBlast_CBE
81.44
55%
-128
- C5 -
3Q4J
1
DPO3B_ECOLI
F:
[1-365]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
-
19
PsiBlast_PDB
81.41
55%
-130
- C5 -
4K3P
6
DPO3B_ECOLI
A:
[1-365]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
--------
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
-
61
PsiBlast_CBE
81.31
55%
-124
- C5 -
4N94
3
DPO3B_ECOLI
A:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
-----
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
-
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
90
PsiBlast_CBE
81.26
55%
-125
- C5 -
1OK7
1
DPO3B_ECOLI
B:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
11
PsiBlast_PDB
81.23
55%
-125
- C5 -
3D1F
4
DPO3B_ECOLI
A:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
44
PsiBlast_CBE
81.09
55%
-128
- C5 -
4OVH
8
?
A:
[1-364]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
--
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
--
4
PsiBlast_PDB
80.98
55%
-125
- C5 -
3QSB
1
DPO3B_ECOLI
B:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
85
PsiBlast_CBE
80.96
55%
-127
- C5 -
3Q4J
1
DPO3B_ECOLI
C:
[1-365]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
-
47
PsiBlast_CBE
80.91
55%
-131
- C5 -
4OVF
7
?
B:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
--------
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
38
PsiBlast_CBE
80.72
55%
-126
- C5 -
4PNW
3
?
A:
[1-364]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
--
12
PsiBlast_PDB
80.65
55%
-125
- C5 -
3D1G
1
DPO3B_ECOLI
A:
[1-366]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
R
L
37
PsiBlast_CBE
80.17
55%
-130
- C5 -
4PNW
7
?
B:
[1-364]
M
K
F
T
V
E
R
E
H
L
L
K
P
L
Q
Q
V
S
G
P
L
G
G
R
P
T
L
P
I
L
G
N
L
L
L
Q
V
A
D
G
T
L
S
L
T
G
T
D
L
E
M
E
M
V
A
R
V
A
L
V
Q
P
H
E
P
G
A
T
T
V
P
A
R
K
F
F
D
I
C
R
G
L
P
E
G
A
E
I
A
V
Q
L
E
G
E
R
M
L
V
R
S
G
R
S
R
F
S
L
S
T
L
P
A
A
D
F
P
N
L
D
D
W
Q
S
E
V
E
F
T
L
P
Q
A
T
M
K
R
L
I
E
A
T
Q
F
S
M
A
H
Q
D
V
R
Y
Y
L
N
G
M
L
F
E
T
E
G
E
E
L
R
T
V
A
T
D
G
H
R
L
A
V
C
S
M
P
IG
Q
S
L
P
S
---
H
S
V
I
V
P
R
K
G
V
I
E
L
M
R
M
L
D
G
G
D
N
P
L
R
V
Q
I
G
S
N
N
I
R
A
H
V
G
D
F
I
F
T
S
K
L
V
D
G
R
F
P
D
Y
R
R
V
L
P
K
N
P
D
K
H
L
E
A
G
C
D
L
L
K
Q
A
F
A
R
A
A
I
L
S
N
E
K
F
R
G
V
R
L
Y
V
S
E
N
Q
L
K
I
T
A
N
N
P
E
Q
E
E
A
E
E
I
L
D
V
T
Y
S
G
A
E
M
E
I
G
F
N
V
S
Y
V
L
D
V
L
N
A
L
K
C
E
N
V
R
M
M
L
T
D
S
V
S
S
V
Q
I
E
D
A
A
S
Q
S
A
A
Y
V
V
M
P
M
--