@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0023: (2015-12-18 )
MAKRIQFAAYGGPEVLEYRDYQPAEPGPREVRVRNRAIGLNFIDTYYRSGLYPAPGLPSGLGSEGAGEVEAVGSEVTRFKVGDRVAYATGPLGAYSELHVLAEEKLVHLPDGIDFEQAAAVMLKGLTTQYLLRQTYELRGGETILFHAAAGGVGLFACQWAKALGVQLIGTVSSPEKARLARQHGAWETIDYSHENVARRVLELTDGKKCPVVYDSVGKDTWETSLDCVAPRGLLVSFGNASGPVTGVNLGILSQKGSLYVTRPTLGSYADTPEKLQAMADELFGLIERGDIRIEINQRFALAEAARAHTELAARRTTGSTVLLP
Atome Classification :
(20 SA)
.........10........20........30........40........50...-...-..60........70.......----.80......-..--------------------------90........100.-......110......---.120---.......130.......140.......150.......160.......170.......180.......190...--....200.......210.......220.......230.......240.---.....-.250.......260..------.....270.......280.......290...--.--...300.......310.......320...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MAK
R
I
Q
F
A
AYGGP
E
V
L
E
YRDYQPAEPGPR
E
V
R
V
RNRAIG
L
N
F
I
D
T
Y
Y
RSGLYPA-PGL-PSGLGSEGAG
E
V
E
A
V
GSE
V
T
R
----
F
KVG
D
R
V
A
Y-AT--------------------------GPL
G
A
Y
S
E
L
H
V
L
A
E
-
E
K
LVHLPDGI
D
F
E
Q
A
---
A
A
V
M
---
L
K
G
L
T
T
Q
Y
L
L
R
Q
T
Y
ELRGG
E
T
I
L
F
H
AAAGG
V
G
L
F
A
C
Q
W
A
K
A
LG
V
Q
L
I
GTVS
S
P
E
K
A
R
L
A
R
QHGAWETIDY
S
H
E
--
N
V
A
R
R
V
L
E
LTDGKKC
P
V
V
Y
DSVGKD
T
W
ETSLDCVAPR
G
L
L
V
SFGNASG---PV
T
G
V
-
N
L
G
I
LSQKG
S
L
Y
V
TRP------TLGSYAD
T
P
E
K
L
Q
A
M
A
D
E
L
F
G
L
I
ERG
D
I
R
I
E
--I--NQRF
A
L
A
E
A
A
R
A
H
T
E
L
AARRTTG
S
T
VLLP
1
PsiBlast_PDB
96.99
74%
-101
* C1 *
3JYL
-
?
A:
[1-325]
M
A
K
R
I
Q
F
S
T
V
G
G
P
E
V
L
E
Y
V
D
F
E
P
E
A
P
G
P
Q
A
V
V
V
R
N
K
A
I
G
L
N
F
I
D
T
Y
Y
R
S
G
L
Y
P
A
-
P
F
L
-
P
S
G
L
G
A
E
G
A
G
V
V
E
A
V
G
D
E
V
T
R
----
F
K
V
G
D
R
V
A
Y
-
G
T
--------------------------
G
P
L
G
A
Y
S
E
V
H
V
L
P
E
-
A
N
L
V
K
L
A
D
S
V
S
F
E
Q
A
---
A
A
L
M
---
L
K
G
L
T
V
Q
Y
L
L
R
Q
T
Y
Q
V
K
P
G
E
I
I
L
F
H
A
A
A
G
G
V
G
S
L
A
C
Q
W
A
K
A
L
G
A
K
L
I
G
T
V
S
S
P
E
K
A
A
H
A
K
A
L
G
A
W
E
T
I
D
Y
S
H
E
--
D
V
A
K
R
V
L
E
L
T
D
G
K
K
C
P
V
V
Y
D
G
V
G
Q
D
T
W
L
T
S
L
D
S
V
A
P
R
G
L
V
V
S
F
G
N
A
S
G
---
P
V
S
G
V
-
N
L
G
I
L
A
Q
K
D
S
V
Y
V
T
R
P
------
T
L
G
S
Y
A
N
N
A
Q
N
L
Q
T
M
A
D
E
L
F
D
M
L
A
S
G
K
L
K
V
D
--
G
--
I
E
Q
Y
A
L
K
D
A
A
K
A
Q
I
E
L
S
A
R
R
T
T
G
S
T
I
L
I
P
92
HHSearch
96.74
75%
-100
- C1 -
3JYN
1
?
A:
[1-325]
M
A
K
R
I
Q
F
S
T
V
G
G
P
E
V
L
E
Y
V
D
F
E
P
E
A
P
G
P
Q
A
V
V
V
R
N
K
A
I
G
L
N
F
I
D
T
Y
Y
R
S
G
L
Y
P
A
-
P
F
L
-
P
S
G
L
G
A
E
G
A
G
V
V
E
A
V
G
D
E
V
T
R
----
F
K
V
G
D
R
V
A
Y
-
G
T
--------------------------
G
P
L
G
A
Y
S
E
V
H
V
L
P
E
-
A
N
L
V
K
L
A
D
S
V
S
F
E
Q
A
---
A
A
L
M
---
L
K
G
L
T
V
Q
Y
L
L
R
Q
T
Y
Q
V
K
P
G
E
I
I
L
F
H
A
A
A
G
G
V
G
S
L
A
C
Q
W
A
K
A
L
G
A
K
L
I
G
T
V
S
S
P
E
K
A
A
H
A
K
A
L
G
A
W
E
T
I
D
Y
S
H
E
--
D
V
A
K
R
V
L
E
L
T
D
G
K
K
C
P
V
V
Y
D
G
V
G
Q
D
T
W
L
T
S
L
D
S
V
A
P
R
G
L
V
V
S
F
G
N
A
S
G
---
P
V
S
G
V
-
N
L
G
I
L
A
Q
K
D
S
V
Y
V
T
R
P
------
T
L
G
S
Y
A
N
N
A
Q
N
L
Q
T
M
A
D
E
L
F
D
M
L
A
S
G
K
L
K
V
D
--
G
--
I
E
Q
Y
A
L
K
D
A
A
K
A
Q
I
E
L
S
A
R
R
T
T
G
S
T
I
L
I
P
2
PsiBlast_PDB
96.42
74%
-100
- C1 -
3JYN
1
?
A:
[1-325]
M
A
K
R
I
Q
F
S
T
V
G
G
P
E
V
L
E
Y
V
D
F
E
P
E
A
P
G
P
Q
A
V
V
V
R
N
K
A
I
G
L
N
F
I
D
T
Y
Y
R
S
G
L
Y
P
A
-
P
F
L
-
P
S
G
L
G
A
E
G
A
G
V
V
E
A
V
G
D
E
V
T
R
----
F
K
V
G
D
R
V
A
Y
-
G
T
--------------------------
G
P
L
G
A
Y
S
E
V
H
V
L
P
E
-
A
N
L
V
K
L
A
D
S
V
S
F
E
Q
A
---
A
A
L
M
---
L
K
G
L
T
V
Q
Y
L
L
R
Q
T
Y
Q
V
K
P
G
E
I
I
L
F
H
A
A
A
G
G
V
G
S
L
A
C
Q
W
A
K
A
L
G
A
K
L
I
G
T
V
S
S
P
E
K
A
A
H
A
K
A
L
G
A
W
E
T
I
D
Y
S
H
E
--
D
V
A
K
R
V
L
E
L
T
D
G
K
K
C
P
V
V
Y
D
G
V
G
Q
D
T
W
L
T
S
L
D
S
V
A
P
R
G
L
V
V
S
F
G
N
A
S
G
---
P
V
S
G
V
-
N
L
G
I
L
A
Q
K
D
S
V
Y
V
T
R
P
------
T
L
G
S
Y
A
N
N
A
Q
N
L
Q
T
M
A
D
E
L
F
D
M
L
A
S
G
K
L
K
V
D
--
G
--
I
E
Q
Y
A
L
K
D
A
A
K
A
Q
I
E
L
S
A
R
R
T
T
G
S
T
I
L
I
P
98
HHSearch
89.81
59%
-99
- C1 -
1QOR
2
QOR1_ECOLI
A:
[2-327]
-
A
T
R
I
E
F
H
K
H
G
G
P
E
V
L
Q
A
V
E
F
T
P
A
D
P
A
E
N
E
I
Q
V
E
N
K
A
I
G
I
N
F
I
D
T
Y
I
R
S
G
L
Y
P
P
-
P
S
L
-
P
S
G
L
G
T
E
A
A
G
I
V
S
K
V
G
S
G
V
K
H
----
I
K
A
G
D
R
V
V
Y
-
A
Q
--------------------------
S
A
L
G
A
Y
S
S
V
H
N
I
I
A
-
D
K
A
A
I
L
P
A
A
I
S
F
E
Q
A
---
A
A
S
F
---
L
K
G
L
T
V
Y
Y
L
L
R
K
T
Y
E
I
K
P
D
E
Q
F
L
F
H
A
A
A
G
G
V
G
L
I
A
C
Q
W
A
K
A
L
G
A
K
L
I
G
T
V
G
T
A
Q
K
A
Q
S
A
L
K
A
G
A
W
Q
V
I
N
Y
R
E
E
--
D
L
V
E
R
L
K
E
I
T
G
G
K
K
V
R
V
V
Y
D
S
V
G
R
D
T
W
E
R
S
L
D
C
L
Q
R
R
G
L
M
V
S
F
G
N
S
S
G
---
A
V
T
G
V
-
N
L
G
I
L
N
Q
K
G
S
L
Y
V
T
R
P
------
S
L
Q
G
Y
I
T
T
R
E
E
L
T
E
A
S
N
E
L
F
S
L
I
A
S
G
V
I
K
V
D
V
A
E
--
Q
Q
K
Y
P
L
K
D
A
Q
R
A
H
E
I
L
E
S
R
A
T
Q
G
S
S
L
L
I
P
21
PsiBlast_CBE
89.71
58%
-97
- C1 -
1QOR
2
QOR1_ECOLI
B:
[2-327]
-
A
T
R
I
E
F
H
K
H
G
G
P
E
V
L
Q
A
V
E
F
T
P
A
D
P
A
E
N
E
I
Q
V
E
N
K
A
I
G
I
N
F
I
D
T
Y
I
R
S
G
L
Y
P
P
-
P
S
L
-
P
S
G
L
G
T
E
A
A
G
I
V
S
K
V
G
S
G
V
K
H
----
I
K
A
G
D
R
V
V
Y
-
A
Q
--------------------------
S
A
L
G
A
Y
S
S
V
H
N
I
I
A
-
D
K
A
A
I
L
P
A
A
I
S
F
E
Q
A
---
A
A
S
F
---
L
K
G
L
T
V
Y
Y
L
L
R
K
T
Y
E
I
K
P
D
E
Q
F
L
F
H
A
A
A
G
G
V
G
L
I
A
C
Q
W
A
K
A
L
G
A
K
L
I
G
T
V
G
T
A
Q
K
A
Q
S
A
L
K
A
G
A
W
Q
V
I
N
Y
R
E
E
--
D
L
V
E
R
L
K
E
I
T
G
G
K
K
V
R
V
V
Y
D
S
V
G
R
D
T
W
E
R
S
L
D
C
L
Q
R
R
G
L
M
V
S
F
G
N
S
S
G
---
A
V
T
G
V
-
N
L
G
I
L
N
Q
K
G
S
L
Y
V
T
R
P
------
S
L
Q
G
Y
I
T
T
R
E
E
L
T
E
A
S
N
E
L
F
S
L
I
A
S
G
V
I
K
V
D
--
V
AE
Q
Q
K
Y
P
L
K
D
A
Q
R
A
H
E
I
L
E
S
R
A
T
Q
G
S
S
L
L
I
P
3
PsiBlast_PDB
89.47
58%
-100
- C1 -
1QOR
2
QOR1_ECOLI
A:
[2-327]
-
A
T
R
I
E
F
H
K
H
G
G
P
E
V
L
Q
A
V
E
F
T
P
A
D
P
A
E
N
E
I
Q
V
E
N
K
A
I
G
I
N
F
I
D
T
Y
I
R
S
G
L
Y
P
P
-
P
S
L
-
P
S
G
L
G
T
E
A
A
G
I
V
S
K
V
G
S
G
V
K
H
----
I
K
A
G
D
R
V
V
Y
-
A
Q
--------------------------
S
A
L
G
A
Y
S
S
V
H
N
I
I
A
-
D
K
A
A
I
L
P
A
A
I
S
F
E
Q
A
---
A
A
S
F
---
L
K
G
L
T
V
Y
Y
L
L
R
K
T
Y
E
I
K
P
D
E
Q
F
L
F
H
A
A
A
G
G
V
G
L
I
A
C
Q
W
A
K
A
L
G
A
K
L
I
G
T
V
G
T
A
Q
K
A
Q
S
A
L
K
A
G
A
W
Q
V
I
N
Y
R
E
E
--
D
L
V
E
R
L
K
E
I
T
G
G
K
K
V
R
V
V
Y
D
S
V
G
R
D
T
W
E
R
S
L
D
C
L
Q
R
R
G
L
M
V
S
F
G
N
S
S
G
---
A
V
T
G
V
-
N
L
G
I
L
N
Q
K
G
S
L
Y
V
T
R
P
------
S
L
Q
G
Y
I
T
T
R
E
E
L
T
E
A
S
N
E
L
F
S
L
I
A
S
G
V
I
K
V
D
--
V
A
E
Q
Q
K
Y
P
L
K
D
A
Q
R
A
H
E
I
L
E
S
R
A
T
Q
G
S
S
L
L
I
P
6
PsiBlast_PDB
84.39
45%
-103
- C1 -
4RVS
-
?
A:
[5-329]
----
I
E
V
T
E
T
G
G
P
G
V
L
R
H
V
D
Q
P
Q
P
Q
P
G
H
G
E
L
L
I
K
A
E
A
I
G
V
N
F
I
D
T
Y
F
R
S
G
Q
Y
P
R
-
E
-
L
-
P
F
V
I
G
S
E
V
C
G
T
V
E
A
V
G
P
G
V
T
A
ADTA
I
S
V
G
D
R
V
V
S
-
A
S
--------------------------
A
N
-
G
A
Y
A
E
F
C
T
A
P
A
-
S
L
T
A
K
V
P
D
D
V
T
S
E
V
A
---
A
S
A
L
---
L
K
G
L
T
A
H
Y
L
L
K
S
V
Y
P
V
K
R
G
D
T
V
L
V
H
A
G
A
G
G
V
G
L
I
L
T
Q
W
A
T
H
L
G
V
R
V
I
T
T
V
S
T
A
E
K
A
K
L
S
K
D
A
G
A
D
V
V
L
D
Y
P
E
D
A
W
Q
F
A
G
R
V
R
E
L
T
G
G
T
G
V
Q
A
V
Y
D
G
V
G
A
T
T
F
D
A
S
L
A
S
L
A
V
R
G
T
L
A
L
F
G
A
A
S
G
---
P
V
P
P
V
-
D
P
Q
R
L
N
A
A
G
S
V
Y
L
T
R
P
------
S
L
F
H
F
T
R
T
G
E
E
F
S
W
R
A
A
E
L
F
D
A
I
G
N
E
A
I
T
V
A
--
V
--
G
G
R
Y
P
L
A
D
A
L
R
A
H
Q
D
L
E
A
R
K
T
V
G
S
V
V
L
L
P
5
PsiBlast_PDB
84.03
45%
-95
- C1 -
4RVU
1
?
A:
[8-332]
----
I
E
V
T
E
T
G
G
P
G
V
L
R
H
V
D
Q
P
Q
P
Q
P
G
H
G
E
L
L
I
K
A
E
A
I
G
V
N
F
I
D
T
Y
F
R
S
G
Q
Y
P
R
-
E
-
L
-
P
F
V
I
G
S
E
V
C
G
T
V
E
A
V
G
P
G
V
T
A
A
D
T
A
I
S
V
G
D
R
V
V
S
-
A
S
--------------------------
A
N
-
G
A
Y
A
E
F
C
T
A
P
A
-
S
L
T
A
K
V
P
D
D
V
T
S
E
V
A
---
A
S
A
L
---
L
K
G
L
T
A
H
Y
L
L
K
S
V
Y
P
V
K
R
G
D
T
V
L
V
H
A
G
A
G
G
V
G
L
I
L
T
Q
W
A
T
H
L
G
V
R
V
I
T
T
V
S
T
A
E
K
A
K
L
S
K
D
A
G
A
D
V
V
L
D
Y
P
E
D
A
W
Q
F
A
G
R
V
R
E
L
T
G
G
T
G
V
Q
A
V
Y
D
G
V
G
A
T
T
F
D
A
S
L
A
S
L
A
V
R
G
T
L
A
L
F
G
A
A
S
G
---
P
V
P
P
V
-
D
P
Q
R
L
N
A
A
G
S
V
Y
L
T
R
P
------
S
L
F
H
F
T
R
T
G
E
E
F
S
W
R
A
A
E
L
F
D
A
I
N
S
E
A
I
T
V
A
--
V
--
G
G
R
Y
P
L
A
D
A
L
R
A
H
Q
D
L
E
A
R
K
T
V
G
S
V
V
L
L
P
23
PsiBlast_CBE
82.94
45%
-96
- C1 -
4RVU
1
?
C:
[8-332]
----
I
E
V
T
E
T
G
G
P
G
V
L
R
H
V
D
Q
P
Q
P
Q
P
G
H
G
E
L
L
I
K
A
E
A
I
G
V
N
F
I
D
T
Y
F
R
S
G
Q
Y
P
R
-
E
-
L
-
P
F
V
I
G
S
E
V
C
G
T
V
E
A
V
G
P
G
V
T
A
ADTA
I
S
V
G
D
R
V
V
S
-
A
S
--------------------------
A
N
-
G
A
Y
A
E
F
C
T
A
P
A
-
S
L
T
A
K
V
P
D
D
V
T
S
E
V
A
---
A
S
A
L
---
L
K
G
L
T
A
H
Y
L
L
K
S
V
Y
P
V
K
R
G
D
T
V
L
V
H
A
G
A
G
G
V
G
L
I
L
T
Q
W
A
T
H
L
G
V
R
V
I
T
T
V
S
T
A
E
K
A
K
L
S
K
D
A
G
A
D
V
V
L
D
Y
P
E
D
A
W
Q
F
A
G
R
V
R
E
L
T
G
G
T
G
V
Q
A
V
Y
D
G
V
G
A
T
T
F
D
A
S
L
A
S
L
A
V
R
G
T
L
A
L
F
G
A
A
S
G
---
P
V
P
P
V
-
D
P
Q
R
L
N
A
A
G
S
V
Y
L
T
R
P
------
S
L
F
H
F
T
R
T
G
E
E
F
S
W
R
A
A
E
L
F
D
A
I
N
S
E
A
I
T
V
A
--
V
--
G
G
R
Y
P
L
A
D
A
L
R
A
H
Q
D
L
E
A
R
K
T
V
G
S
V
V
L
L
P
24
PsiBlast_CBE
82.33
45%
-95
- C1 -
4RVU
1
?
B:
[8-332]
----
I
E
V
T
E
T
G
G
P
G
V
L
R
H
V
D
Q
P
Q
P
Q
P
G
H
G
E
L
L
I
K
A
E
A
I
G
V
N
F
I
D
T
Y
F
R
S
G
Q
Y
P
R
-
E
-
L
-
P
F
V
I
G
S
E
V
C
G
T
V
E
A
V
G
P
G
V
T
A
A
D
T
A
I
S
V
G
D
R
V
V
S
-
A
S
--------------------------
A
N
-
G
A
Y
A
E
F
C
T
A
P
A
-
S
L
T
A
K
V
P
D
D
V
T
S
E
V
A
---
A
S
A
L
---
L
K
G
L
T
A
H
Y
L
L
K
S
V
Y
P
V
K
R
G
D
T
V
L
V
H
A
G
A
G
G
V
G
L
I
L
T
Q
W
A
T
H
L
G
V
R
V
I
T
T
V
S
T
A
E
K
A
K
L
S
K
D
A
G
A
D
V
V
L
D
Y
P
E
D
A
W
Q
F
A
G
R
V
R
E
L
-
G
G
T
G
V
Q
A
V
Y
D
G
V
G
A
T
T
F
D
A
S
L
A
S
L
A
V
R
G
T
L
A
L
F
G
A
A
S
G
---
P
V
P
P
V
-
D
P
Q
R
L
N
A
A
G
S
V
Y
L
T
R
P
------
S
L
F
H
F
T
R
T
G
E
E
F
S
W
R
A
A
E
L
F
D
A
I
N
S
E
A
I
T
V
A
--
V
--
G
G
R
Y
P
L
A
D
A
L
R
A
H
Q
D
L
E
A
R
K
T
V
G
S
V
V
L
L
P
22
PsiBlast_CBE
82.31
45%
-95
- C1 -
4RVU
1
?
D:
[8-332]
----
I
E
V
T
E
T
G
G
P
G
V
L
R
H
V
D
Q
P
Q
P
Q
P
G
H
G
E
L
L
I
K
A
E
A
I
G
V
N
F
I
D
T
Y
F
R
S
G
Q
Y
P
R
-
E
-
L
-
P
F
V
I
G
S
E
V
C
G
T
V
E
A
V
G
P
G
---A---
I
S
V
G
D
R
V
V
S
-
A
S
--------------------------
A
N
-
G
A
Y
A
E
F
C
T
A
P
A
-
S
L
T
A
K
V
P
D
D
V
T
S
E
V
A
---
A
S
A
L
---
L
K
G
L
T
A
H
Y
L
L
K
S
V
Y
P
V
K
R
G
D
T
V
L
V
H
A
G
A
G
G
V
G
L
I
L
T
Q
W
A
T
H
L
G
V
R
V
I
T
T
V
S
T
A
E
K
A
K
L
S
K
D
A
G
A
D
V
V
L
D
Y
P
E
D
A
W
Q
F
A
G
R
V
R
E
L
T
G
G
T
G
V
Q
A
V
Y
D
G
V
G
A
T
T
F
D
A
S
L
A
S
L
A
V
R
G
T
L
A
L
F
G
A
A
S
G
---
P
V
P
P
V
-
D
P
Q
R
L
N
A
A
G
S
V
Y
L
T
R
P
------
S
L
F
H
F
T
R
T
G
E
E
F
S
W
R
A
A
E
L
F
D
A
I
N
S
E
A
I
T
V
A
--
V
--
G
G
R
Y
P
L
A
D
A
L
R
A
H
Q
D
L
E
A
R
K
T
V
G
S
V
V
L
L
P
99
HHSearch
77.10
42%
-91
- C1 -
1WLY
-
CAA43_BURSP
A:
[2-331]
-
V
M
A
A
V
I
H
K
K
G
G
P
D
N
F
V
W
E
E
V
K
V
G
S
P
G
P
G
Q
V
R
L
R
N
T
A
I
G
V
N
F
L
D
T
Y
H
R
A
--------
P
-
P
I
V
V
G
F
E
A
A
A
V
V
E
E
V
G
P
G
V
T
D
----
F
T
V
G
E
R
V
C
T
-
C
L
--------------------------
P
P
L
G
A
Y
S
Q
E
R
L
Y
P
A
-
E
K
L
I
K
V
P
K
D
L
D
L
D
D
V
H
L
-
A
G
L
M
---
L
K
G
M
T
A
Q
Y
L
L
H
Q
T
H
K
V
K
P
G
D
Y
V
L
I
H
A
A
A
G
G
M
G
H
I
M
V
P
W
A
R
H
L
G
A
T
V
I
G
T
V
S
T
E
E
K
A
E
T
A
R
K
L
G
C
H
H
T
I
N
Y
S
T
Q
--
D
F
A
E
V
V
R
E
I
T
G
G
K
G
V
D
V
V
Y
D
S
I
G
K
D
T
L
Q
K
S
L
D
C
L
R
P
R
G
M
C
A
A
Y
G
H
A
S
G
---
V
A
D
P
I
-
R
---
V
--
V
E
D
L
G
V
R
G
S
L
F
I
T
RP
A
L
W
H
Y
M
S
N
R
S
E
I
D
E
G
S
K
C
L
F
D
A
V
K
A
G
V
L
H
S
S
--
V
--
A
K
T
F
P
L
R
E
A
A
A
A
H
K
Y
M
G
G
R
Q
T
I
G
S
I
V
L
L
P
4
PsiBlast_PDB
77.03
44%
-98
- C1 -
1WLY
-
CAA43_BURSP
A:
[11-331]
----------
G
G
P
D
N
F
V
W
E
E
V
K
V
G
S
P
G
P
G
Q
V
R
L
R
N
T
A
I
G
V
N
F
L
D
T
Y
H
R
A
---------P
P
I
V
V
G
F
E
A
A
A
V
V
E
E
V
G
P
G
V
T
D
----
F
T
V
G
E
R
V
C
T
-
C
L
--------------------------
P
P
L
G
A
Y
S
Q
E
R
L
Y
P
A
-
E
K
L
I
K
V
P
K
D
L
D
L
D
D
V
H
L
-
A
G
L
M
---
L
K
G
M
T
A
Q
Y
L
L
H
Q
T
H
K
V
K
P
G
D
Y
V
L
I
H
A
A
A
G
G
M
G
H
I
M
V
P
W
A
R
H
L
G
A
T
V
I
G
T
V
S
T
E
E
K
A
E
T
A
R
K
L
G
C
H
H
T
I
N
Y
S
T
Q
--
D
F
A
E
V
V
R
E
I
T
G
G
K
G
V
D
V
V
Y
D
S
I
G
K
D
T
L
Q
K
S
L
D
C
L
R
P
R
G
M
C
A
A
Y
G
H
A
S
G
VAD
P
I
R
V
V
E
D
L
G
V
---
R
G
S
L
F
I
T
R
P
------
A
L
W
H
Y
M
S
N
R
S
E
I
D
E
G
S
K
C
L
F
D
A
V
K
A
G
V
L
H
S
S
--
V
--
A
K
T
F
P
L
R
E
A
A
A
A
H
K
Y
M
G
G
R
Q
T
I
G
S
I
V
L
L
P
25
PsiBlast_CBE
75.03
36%
-88
- C1 -
3QWB
2
QOR_YEAST
D:
[10-330]
--
K
V
I
L
I
D
E
I
G
G
Y
D
V
I
K
Y
E
D
Y
P
V
P
S
I
S
E
E
E
L
L
I
K
N
K
Y
T
G
V
N
Y
I
E
S
Y
F
R
K
G
I
Y
P
C
-
E
K
--
P
Y
V
L
G
R
E
A
S
G
T
V
V
A
K
G
K
G
V
T
N
----
F
E
V
G
D
Q
V
A
Y
I
S
N
--------------------------
S
T
F
A
Q
Y
S
K
I
S
--
S
Q
-
G
P
V
M
K
L
P
K
G
T
S
D
E
E
L
KLY
A
A
G
L
---
L
Q
V
L
T
A
L
S
F
T
N
E
A
Y
H
V
K
K
G
D
Y
V
L
L
F
A
A
A
G
G
V
G
L
I
L
N
Q
L
L
K
M
K
G
A
H
T
I
A
V
A
S
T
D
E
K
L
K
I
A
K
E
Y
G
A
E
Y
L
I
N
A
S
K
E
--
D
I
L
R
Q
V
L
K
F
T
N
G
K
G
V
D
A
S
F
D
S
V
G
K
D
T
F
E
I
S
L
A
A
L
K
R
K
G
V
F
V
S
F
G
N
A
S
G
---
L
I
P
P
F
-
S
I
T
R
L
S
P
K
-
N
I
T
L
V
R
P
------
Q
L
Y
G
Y
I
A
D
P
E
E
W
K
Y
Y
S
D
E
F
F
G
L
V
N
S
K
K
L
N
I
K
--
I
--
Y
K
T
Y
P
L
R
D
Y
R
T
A
A
A
D
I
E
S
R
K
T
V
G
K
L
V
L
E
I
27
PsiBlast_CBE
74.63
36%
-86
- C1 -
3QWB
2
QOR_YEAST
B:
[10-330]
--
K
V
I
L
I
D
E
I
G
G
Y
D
V
I
K
Y
E
D
Y
P
V
P
S
I
S
E
E
E
L
L
I
K
N
K
Y
T
G
V
N
Y
I
E
S
Y
F
R
K
G
I
Y
P
C
-
E
K
--
P
Y
V
L
G
R
E
A
S
G
T
V
V
A
K
G
K
G
V
T
N
----
F
E
V
G
D
Q
V
A
Y
I
S
N
--------------------------
S
T
F
A
Q
Y
S
K
I
S
--
S
Q
-
G
P
V
M
K
L
P
K
G
T
S
D
E
E
L
KLY
A
A
G
L
---
L
Q
V
L
T
A
L
S
F
T
N
E
A
Y
H
V
K
K
G
D
Y
V
L
L
F
A
A
A
G
G
V
G
L
I
L
N
Q
L
L
K
M
K
G
A
H
T
I
A
V
A
S
T
D
E
K
L
K
I
A
K
E
Y
G
A
E
Y
L
I
N
A
S
K
E
--
D
I
L
R
Q
V
L
K
F
T
N
G
K
G
V
D
A
S
F
D
S
V
G
K
D
T
F
E
I
S
L
A
A
L
K
R
K
G
V
F
V
S
F
G
N
A
S
G
---
L
I
P
P
F
-
S
I
T
R
L
S
P
K
-
N
I
T
L
V
R
P
------
Q
L
Y
G
Y
I
A
D
P
E
E
W
K
Y
Y
S
D
E
F
F
G
L
V
N
S
K
K
L
N
I
K
--
I
--
Y
K
T
Y
P
L
R
D
Y
R
T
A
A
A
D
I
E
S
R
K
T
V
G
K
L
V
L
E
I
26
PsiBlast_CBE
74.20
36%
-87
- C1 -
3QWB
2
QOR_YEAST
C:
[10-330]
--
K
V
I
L
I
D
E
I
G
G
Y
D
V
I
K
Y
E
D
Y
P
V
P
S
I
S
E
E
E
L
L
I
K
N
K
Y
T
G
V
N
Y
I
E
S
Y
F
R
K
G
I
Y
P
C
-
E
K
--
P
Y
V
L
G
R
E
A
S
G
T
V
V
A
K
G
K
G
V
T
N
----
F
E
V
G
D
Q
V
A
Y
I
S
N
--------------------------
S
T
F
A
Q
Y
S
K
I
S
--
S
Q
-
G
P
V
M
K
L
P
K
G
T
S
D
E
E
L
KLY
A
A
G
L
---
L
Q
V
L
T
A
L
S
F
T
N
E
A
Y
H
V
K
K
G
D
Y
V
L
L
F
A
A
A
G
G
V
G
L
I
L
N
Q
L
L
K
M
K
G
A
H
T
I
A
V
A
S
T
D
E
K
L
K
I
A
K
E
Y
G
A
E
Y
L
I
N
A
S
K
E
--
D
I
L
R
Q
V
L
K
F
T
N
G
K
G
V
D
A
S
F
D
S
V
G
K
D
T
F
E
I
S
L
A
A
L
K
R
K
G
V
F
V
S
F
G
N
A
S
G
---
L
I
P
P
F
-
S
I
T
R
L
S
P
K
-
N
I
T
L
V
R
P
------
Q
L
Y
G
Y
I
A
D
P
E
E
W
K
Y
Y
S
D
E
F
F
G
L
V
N
S
K
K
L
N
I
K
--
I
--
Y
K
T
Y
P
L
R
D
Y
R
T
A
A
A
D
I
E
S
R
K
T
V
G
K
L
V
L
E
I
97
HHSearch
73.88
35%
-90
- C1 -
3QWB
3
QOR_YEAST
A:
[8-332]
Q
Q
K
V
I
L
I
D
E
I
G
G
Y
D
V
I
K
Y
E
D
Y
P
V
P
S
I
S
E
E
E
L
L
I
K
N
K
Y
T
G
V
N
Y
I
E
S
Y
F
R
K
G
I
Y
P
C
--
E
K
-
P
Y
V
L
G
R
E
A
S
G
T
V
V
A
K
G
K
G
V
T
N
----
F
E
V
G
D
Q
V
A
Y
-
I
----------------------------
S
N
S
T
F
A
Q
Y
S
K
I
S
S
Q
G
P
V
M
K
L
P
K
G
T
S
D
E
E
L
---
K
L
Y
A
A
G
L
L
Q
V
L
T
A
L
S
F
T
N
E
A
Y
H
V
K
K
G
D
Y
V
L
L
F
A
A
A
G
G
V
G
L
I
L
N
Q
L
L
K
M
K
G
A
H
T
I
A
V
A
S
T
D
E
K
L
K
I
A
K
E
Y
G
A
E
Y
L
I
N
A
S
K
E
--
D
I
L
R
Q
V
L
K
F
T
N
G
K
G
V
D
A
S
F
D
S
V
G
K
D
T
F
E
I
S
L
A
A
L
K
R
K
G
V
F
V
S
F
G
N
A
S
G
---
L
I
P
P
F
-
S
I
T
R
L
S
-
P
K
N
I
T
L
V
R
P
------
Q
L
Y
G
Y
I
A
D
P
E
E
W
K
Y
Y
S
D
E
F
F
G
L
V
N
S
K
K
L
N
I
K
--
I
--
Y
K
T
Y
P
L
R
D
Y
R
T
A
A
A
D
I
E
S
R
K
T
V
G
K
L
V
L
E
I
7
PsiBlast_PDB
73.63
36%
-89
- C1 -
3QWA
-
QOR_YEAST
A:
[10-330]
--
K
V
I
L
I
D
E
I
G
G
Y
D
V
I
K
Y
E
D
Y
P
V
P
S
I
S
E
E
E
L
L
I
K
N
K
Y
T
G
V
N
Y
I
E
S
Y
F
R
K
G
I
Y
P
C
-
E
K
--
P
Y
V
L
G
R
E
A
S
G
T
V
V
A
K
G
K
G
V
T
N
----
F
E
V
G
D
Q
V
A
Y
I
S
N
--------------------------
S
T
F
A
Q
Y
S
K
I
S
--
S
Q
-
G
P
V
M
K
L
P
K
G
T
S
D
E
E
L
K
L
Y
A
A
G
L
---
L
Q
V
L
T
A
L
S
F
T
N
E
A
Y
H
V
K
K
G
D
Y
V
L
L
F
A
A
A
G
G
V
G
L
I
L
N
Q
L
L
K
M
K
G
A
H
T
I
A
V
A
S
T
D
E
K
L
K
I
A
K
E
Y
G
A
E
Y
L
I
N
A
S
K
E
--
D
I
L
R
Q
V
L
K
F
T
N
G
K
G
V
D
A
S
F
D
S
V
G
K
D
T
F
E
I
S
L
A
A
L
K
R
K
G
V
F
V
S
F
G
N
A
S
G
---
L
I
P
P
F
-
S
I
T
R
L
S
P
K
-
N
I
T
L
V
R
P
------
Q
L
Y
G
Y
I
A
D
P
E
E
W
K
Y
Y
S
D
E
F
F
G
L
V
N
S
K
K
L
N
I
K
--
I
--
Y
K
T
Y
P
L
R
D
Y
R
T
A
A
A
D
I
E
S
R
K
T
V
G
K
L
V
L
E
I
8
PsiBlast_PDB
73.20
36%
-86
- C1 -
3QWB
3
QOR_YEAST
A:
[10-330]
--
K
V
I
L
I
D
E
I
G
G
Y
D
V
I
K
Y
E
D
Y
P
V
P
S
I
S
E
E
E
L
L
I
K
N
K
Y
T
G
V
N
Y
I
E
S
Y
F
R
K
G
I
Y
P
C
-
E
K
--
P
Y
V
L
G
R
E
A
S
G
T
V
V
A
K
G
K
G
V
T
N
----
F
E
V
G
D
Q
V
A
Y
I
S
N
--------------------------
S
T
F
A
Q
Y
S
K
I
S
--
S
Q
-
G
P
V
M
K
L
P
K
G
T
S
D
E
E
L
K
L
Y
A
A
G
L
---
L
Q
V
L
T
A
L
S
F
T
N
E
A
Y
H
V
K
K
G
D
Y
V
L
L
F
A
A
A
G
G
V
G
L
I
L
N
Q
L
L
K
M
K
G
A
H
T
I
A
V
A
S
T
D
E
K
L
K
I
A
K
E
Y
G
A
E
Y
L
I
N
A
S
K
E
--
D
I
L
R
Q
V
L
K
F
T
N
G
K
G
V
D
A
S
F
D
S
V
G
K
D
T
F
E
I
S
L
A
A
L
K
R
K
G
V
F
V
S
F
G
N
A
S
G
---
L
I
P
P
F
-
S
I
T
R
L
S
P
K
-
N
I
T
L
V
R
P
------
Q
L
Y
G
Y
I
A
D
P
E
E
W
K
Y
Y
S
D
E
F
F
G
L
V
N
S
K
K
L
N
I
K
--
I
--
Y
K
T
Y
P
L
R
D
Y
R
T
A
A
A
D
I
E
S
R
K
T
V
G
K
L
V
L
E
I
95
HHSearch
69.22
34%
-86
- C1 -
2EIH
1
?
A:
[1-342]
-
M
R
A
V
V
M
R
A
R
G
G
P
E
V
L
E
V
A
D
L
P
V
P
E
P
G
P
K
E
V
R
V
R
L
K
A
A
A
L
N
H
L
D
V
W
V
R
K
G
V
A
S
P
K
L
P
L
-
P
H
V
L
G
A
D
G
S
G
V
V
D
A
V
G
P
G
V
E
G
----
F
A
P
G
D
E
V
V
I
-
N
P
GLSCGRC
E
R
C
L
A
GEDNLCPRYQILGE
H
R
H
G
T
Y
A
E
Y
V
V
L
P
E
-
A
N
L
A
P
K
P
K
N
L
S
F
E
E
A
---
A
A
I
P
---
L
T
F
L
T
A
W
Q
M
V
V
D
K
L
G
V
R
P
G
D
D
V
L
V
M
A
A
G
S
G
V
S
V
A
A
I
Q
I
A
K
L
F
G
A
R
V
I
A
T
A
G
S
E
D
K
L
R
R
A
K
A
L
G
A
D
E
T
V
N
Y
T
H
P
--
D
W
P
K
E
V
R
R
L
T
G
G
K
G
A
D
K
V
V
D
H
T
G
A
L
Y
F
E
G
V
I
K
A
T
A
N
G
G
R
I
A
I
A
G
A
S
S
G
---
Y
E
G
T
L
-
P
F
A
H
V
F
-
Y
R
Q
L
S
I
L
G
S
------
T
M
A
----
S
----
K
S
R
L
F
P
I
L
R
F
V
E
E
G
K
L
K
P
V
--
V
--
G
Q
V
L
P
L
E
A
A
A
E
G
H
R
L
L
E
E
R
R
V
F
G
K
V
V
L
Q
V