@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0025: (2015-12-18 )
MDRYCVFGNPIGHSKSPLIHRLFAEQTGEALVYDAQLAPLDDFPGFARRFFEQGKGANVTVPFKEEAYRLVDELSERATRAGAVNTLIRLADGRLRGDNTDGAGLLRDLTANAGVELRGKRVLLLGAGGAVRGVLEPFLGECPAELLIANRTARKAVDLAERFADLGAVHGCGFAEVEGPFDLIVNGTSASLAGDVPPLAQSVIEPGRTVCYDMMYAKEPTAFNRWAAERGAARTLDGLGMLVEQAAEAFFLWRGVRPASAPVLETLRRQLATV
Atome Classification :
(45 SA)
.........10........20----........----30........40.-.......50.-.-----..-.....60........70........80........90........100.......110.-.......120.......130.......140........150.......160.....------..170..-...-.-.-180.......190....--.---..-200---....---...----.210......-.220.......230..-.....240.......250.......260.......270..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MDR
Y
C
V
FGNPIGHSK
S
P
L
I
H
R
----
L
F
A
E
QTG
E
----
A
L
V
YDAQLAPLDD-F
P
G
F
A
R
R
F
-
F
-E-----QG-KGA
N
V
T
V
P
F
K
E
E
A
Y
R
L
V
D
E
L
S
E
R
ATRA
G
A
V
N
T
L
I
R
LADGRLRGDNTD
G
A
G
L
L
R
D
L
TA-N-A
G
V
E
L
RG
K
R
V
L
L
L
GAG
G
A
V
R
G
V
L
E
P
F
L
G
-EC
P
A
E
L
L
IAN
R
T
A
R
K
A
V
D
L
A
E
R
F
A
D
L
G------AVHGCGF-AEV-E-G-
P
F
D
L
I
V
NGTSASLAGDV--
P
---
P
L
-
A
Q
----
S
V
IE---PG
R
----
T
V
C
Y
D
M
MYAK-EPT
A
F
N
R
W
A
A
ERGAAR-
T
L
D
G
L
G
M
L
V
E
Q
A
A
E
A
F
F
L
W
RGVRPAS
A
P
V
L
E
T
L
R
R
Q
LATV
1
PsiBlast_PDB
98.95
70%
-103
- C7 -
4OMU
-
?
A:
[1-272]
M
D
Q
Y
V
V
F
G
N
P
I
G
H
S
K
S
P
L
I
H
R
----
L
F
A
E
Q
T
G
Q
----
D
L
E
Y
A
T
L
L
A
P
L
D
E
-
F
S
D
C
A
R
G
F
-
F
-
K
-----
Q
G
-
S
G
G
N
V
T
V
P
F
K
E
E
A
F
R
L
C
D
S
L
T
P
R
A
R
R
A
G
A
V
N
T
L
S
K
L
A
D
G
T
L
Q
G
D
N
T
D
G
A
G
L
V
R
D
L
T
V
-
N
-
A
G
V
E
L
A
G
K
R
I
L
I
L
G
A
G
G
A
V
R
G
V
L
E
P
I
L
A
-
H
K
P
Q
S
L
V
I
A
N
R
T
V
E
K
A
E
Q
L
A
R
E
F
D
E
L
G
------
P
V
V
A
S
G
F
-
A
W
L
-
Q
-
E
-
P
V
D
V
I
I
N
A
T
S
A
S
L
A
G
E
L
--
P
---
P
I
-
A
D
----
S
L
V
E
---
A
G
R
----
T
V
C
Y
D
M
M
Y
G
K
-
E
P
T
P
F
C
Q
W
A
T
K
L
G
A
A
K
-
V
L
D
G
L
G
M
L
A
E
Q
A
A
E
A
F
F
I
W
R
G
V
R
P
D
T
A
P
V
L
A
E
L
R
R
Q
L
A
R
G
21
PsiBlast_CBE
97.18
70%
-102
- C7 -
4OMU
1
?
B:
[1-272]
M
D
Q
Y
V
V
F
G
N
P
I
G
H
S
K
S
P
L
I
H
R
----
L
F
A
E
Q
T
G
Q
----
D
L
E
Y
A
T
L
L
A
P
L
D
E
-
F
S
D
C
A
R
G
F
-
F
-
K
-----
Q
G
-
S
G
G
N
V
T
V
P
F
K
E
E
A
F
R
L
C
D
S
L
T
P
R
A
R
R
A
G
A
V
N
T
L
S
K
L
A
D
G
T
L
Q
G
D
N
T
D
G
A
G
L
V
R
D
L
T
V
-
N
-
A
G
V
E
L
A
G
K
R
I
L
I
L
G
A
G
G
A
V
R
G
V
L
E
P
I
L
A
-
H
K
P
Q
S
L
V
I
A
N
R
T
V
E
K
A
E
Q
L
A
R
E
F
D
E
L
G
------
P
V
V
A
S
G
F
-
A
W
L
-
Q
-
E
-
P
V
D
V
I
I
N
A
T
S
A
S
L
A
G
E
L
--
P
---
P
I
-
A
D
----
S
L
V
E
---
A
G
R
----
T
V
C
Y
D
M
M
Y
G
K
-
E
P
T
P
F
C
Q
W
A
T
K
L
G
A
A
K
-
V
L
D
G
L
G
M
L
A
E
Q
A
A
E
A
F
F
I
W
R
G
V
R
P
D
T
A
P
V
L
A
E
L
R
R
Q
L
A
R
G
28
PsiBlast_CBE
92.32
53%
-100
- C7 -
1NYT
5
AROE_ECOLI
D:
[1-270]
M
E
T
Y
A
V
F
G
N
P
I
A
H
S
K
S
P
F
I
H
Q
----
Q
F
A
Q
Q
L
N
I
----
E
H
P
Y
G
R
V
L
A
P
I
N
D
-
F
I
N
T
L
N
A
F
-
F
-
S
-----
A
G
G
K
G
A
N
V
T
V
P
F
K
E
E
A
F
A
R
A
D
E
L
T
E
R
A
A
L
A
G
A
V
N
T
L
M
R
L
E
D
G
R
L
L
G
D
N
T
D
G
V
G
L
L
S
D
L
E
R
-
L
-
S
F
I
R
-
P
G
L
R
I
L
L
I
G
A
G
G
A
S
R
G
V
L
L
P
L
L
S
L
D
C
--
A
V
T
I
T
N
R
T
V
S
R
A
E
E
L
A
K
L
F
A
H
T
G
------
S
I
Q
A
L
S
M
-
D
E
L
-
E
-
G
H
E
F
D
L
I
I
N
A
T
S
S
G
I
S
G
D
I
--
P
---
A
I
-
P
S
----
S
L
I
H
---
P
G
-----
I
Y
C
Y
D
M
F
Y
Q
K
-
G
K
T
P
F
L
A
W
C
E
Q
R
G
S
K
R
-
N
A
D
G
L
G
M
L
V
A
Q
A
A
H
A
F
L
L
W
H
G
V
L
P
D
V
E
P
V
I
K
Q
L
Q
E
E
L
---
29
PsiBlast_CBE
92.03
53%
-101
- C7 -
1NYT
6
AROE_ECOLI
C:
[1-269]
M
E
T
Y
A
V
F
G
N
P
I
A
H
S
K
S
P
F
I
H
Q
----
Q
F
A
Q
Q
L
N
I
----
E
H
P
Y
G
R
V
L
A
P
I
N
D
-
F
I
N
T
L
N
A
F
-
F
-
S
-----
A
G
G
K
G
A
N
V
T
V
P
F
K
E
E
A
F
A
R
A
D
E
L
T
E
R
A
A
L
A
G
A
V
N
T
L
M
R
L
E
D
G
R
L
L
G
D
N
T
D
G
V
G
L
L
S
D
L
E
R
-
L
-
S
F
I
R
-
P
G
L
R
I
L
L
I
G
A
G
G
A
S
R
G
V
L
L
P
L
L
S
L
D
C
--
A
V
T
I
T
N
R
T
V
S
R
A
E
E
L
A
K
L
F
A
H
T
G
------
S
I
Q
A
L
S
M
-
D
E
L
-
E
-
G
H
E
F
D
L
I
I
N
A
T
S
S
G
I
S
G
D
I
--
P
---
A
I
-
P
S
----
S
L
I
H
---
P
G
-----
I
Y
C
Y
D
M
F
Y
Q
K
-
G
K
T
P
F
L
A
W
C
E
Q
R
G
S
K
R
-
N
A
D
G
L
G
M
L
V
A
Q
A
A
H
A
F
L
L
W
H
G
V
L
P
D
V
E
P
V
I
K
Q
L
Q
E
E
----
30
PsiBlast_CBE
91.71
53%
-95
- C7 -
1NYT
5
AROE_ECOLI
B:
[1-271]
M
E
T
Y
A
V
F
G
N
P
I
A
H
S
K
S
P
F
I
H
Q
----
Q
F
A
Q
Q
L
N
I
----
E
H
P
Y
G
R
V
L
A
P
I
N
D
-
F
I
N
T
L
N
A
F
-
F
-
S
-----
A
G
G
K
G
A
N
V
T
V
P
F
K
E
E
A
F
A
R
A
D
E
L
T
E
R
A
A
L
A
G
A
V
N
T
L
M
R
L
E
D
G
R
L
L
G
D
N
T
D
G
V
G
L
L
S
D
L
E
R
-
L
-
S
F
I
R
-
P
G
L
R
I
L
L
I
G
A
G
G
A
S
R
G
V
L
L
P
L
L
S
L
D
C
--
A
V
T
I
T
N
R
T
V
S
R
A
E
E
L
A
K
L
F
A
H
T
G
------
S
I
Q
A
L
S
M
-
D
E
L
-
E
-
G
H
E
F
D
L
I
I
N
A
T
S
S
G
I
S
G
D
I
--
P
---
A
I
-
P
S
----
S
L
I
H
---
P
G
-----
I
Y
C
Y
D
M
F
Y
Q
K
-
G
K
T
P
F
L
A
W
C
E
Q
R
G
S
K
R
-
N
A
D
G
L
G
M
L
V
A
Q
A
A
H
A
F
L
L
W
H
G
V
L
P
D
V
E
P
V
I
K
Q
L
Q
E
E
L
S
--
5
PsiBlast_PDB
90.50
53%
-97
- C7 -
1NYT
7
AROE_ECOLI
A:
[1-271]
M
E
T
Y
A
V
F
G
N
P
I
A
H
S
K
S
P
F
I
H
Q
----
Q
F
A
Q
Q
L
N
I
----
E
H
P
Y
G
R
V
L
A
P
I
N
D
-
F
I
N
T
L
N
A
F
-
F
-
S
-----
A
G
G
K
G
A
N
V
T
V
P
F
K
E
E
A
F
A
R
A
D
E
L
T
E
R
A
A
L
A
G
A
V
N
T
L
M
R
L
E
D
G
R
L
L
G
D
N
T
D
G
V
G
L
L
S
D
L
E
R
-
L
-
S
F
I
R
-
P
G
L
R
I
L
L
I
G
A
G
G
A
S
R
G
V
L
L
P
L
L
S
L
D
C
--
A
V
T
I
T
N
R
T
V
S
R
A
E
E
L
A
K
L
F
A
H
T
G
------
S
I
Q
A
L
S
M
-
D
E
L
-
E
-
G
H
E
F
D
L
I
I
N
A
T
S
S
G
I
S
G
D
I
--
P
---
A
I
-
P
S
----
S
L
I
H
---
P
G
-----
I
Y
C
Y
D
M
F
Y
Q
K
-
G
K
T
P
F
L
A
W
C
E
Q
R
G
S
K
R
-
N
A
D
G
L
G
M
L
V
A
Q
A
A
H
A
F
L
L
W
H
G
V
L
P
D
V
E
P
V
I
K
Q
L
Q
E
E
L
S
--
24
PsiBlast_CBE
90.37
55%
-96
- C7 -
3PGJ
1
AROE_VIBCH
D:
[29-298]
I
D
Q
Y
A
V
F
G
N
P
I
N
H
S
K
S
P
F
I
H
T
----
L
F
A
R
Q
T
Q
Q
----
S
M
I
Y
T
A
Q
C
V
P
V
D
G
-
F
T
E
A
A
K
H
F
-
F
-
A
-----
Q
G
G
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
K
K
L
D
D
G
E
I
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
L
A
-
Q
-
Q
-
V
L
L
K
G
A
T
I
L
L
I
G
A
G
G
A
A
R
G
V
L
K
P
L
L
D
-
Q
Q
P
A
S
I
T
V
T
N
R
T
F
A
K
A
E
Q
L
A
E
L
V
A
A
Y
G
------
E
V
K
A
Q
A
F
-
E
Q
L
-
K
-
Q
-
S
Y
D
V
I
I
N
S
T
S
A
S
L
D
G
E
L
--
P
---
A
I
--
D
----
P
V
I
F
---
S
S
R
----
S
V
C
Y
D
M
M
Y
G
K
-
G
Y
T
V
F
N
Q
W
A
R
Q
H
G
C
A
Q
-
A
I
D
G
L
G
M
L
V
G
Q
A
A
E
S
F
M
L
W
R
G
L
R
P
G
T
K
Q
I
L
R
E
L
R
K
N
L
E
--
3
PsiBlast_PDB
90.19
55%
-101
- C7 -
3SEF
1
AROE_VIBCH
A:
[29-298]
I
D
Q
Y
A
V
F
G
N
P
---
S
K
S
P
F
I
H
T
----
L
F
A
R
Q
T
Q
Q
----
S
M
I
Y
T
A
Q
C
V
P
-
D
G
-
F
T
E
A
A
K
H
F
-
F
-
A
-----
Q
G
G
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
K
K
L
D
D
G
E
I
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
L
A
-
Q
-
Q
-
V
L
L
K
G
A
T
I
L
L
I
G
A
G
G
A
A
R
G
V
L
K
P
L
L
D
-
Q
Q
P
A
S
I
T
V
T
N
R
T
F
A
K
A
E
Q
L
A
E
L
V
A
A
Y
G
------
E
V
K
A
Q
A
F
-
E
Q
L
-
K
-
Q
-
S
Y
D
V
I
I
N
S
T
S
A
S
L
D
G
E
L
--
P
---
A
I
--
D
----
P
V
I
F
---
S
S
R
----
S
V
C
Y
D
M
M
Y
G
K
-
G
Y
T
V
F
N
Q
W
A
R
Q
H
G
C
A
Q
-
A
I
D
G
L
G
M
L
V
G
Q
A
A
E
S
F
M
L
W
R
G
L
R
P
G
T
K
Q
I
L
R
E
L
R
K
N
L
E
G
-
2
PsiBlast_PDB
90.08
55%
-100
- C7 -
3PGJ
1
AROE_VIBCH
A:
[29-298]
I
D
Q
Y
A
V
F
G
N
P
I
N
H
S
K
S
P
F
I
H
T
----
L
F
A
R
Q
T
Q
Q
----
S
M
I
Y
T
A
Q
C
V
P
V
D
G
-
F
T
E
A
A
K
H
F
-
F
-
A
-----
Q
G
G
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
K
K
L
D
D
G
E
I
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
L
A
-
Q
-
Q
-
V
L
L
K
G
A
T
I
L
L
I
G
A
G
G
A
A
R
G
V
L
K
P
L
L
D
-
Q
Q
P
A
S
I
T
V
T
N
R
T
F
A
K
A
E
Q
L
A
E
L
V
A
A
Y
G
------
E
V
K
A
Q
A
F
-
E
Q
L
-
K
-
Q
-
S
Y
D
V
I
I
N
S
T
S
A
S
L
D
G
E
L
--
P
---
A
I
--
D
----
P
V
I
F
---
S
S
R
----
S
V
C
Y
D
M
M
Y
G
K
-
G
Y
T
V
F
N
Q
W
A
R
Q
H
G
C
A
Q
-
A
I
D
G
L
G
M
L
V
G
Q
A
A
E
S
F
M
L
W
R
G
L
R
P
G
T
K
Q
I
L
R
E
L
R
K
N
L
E
G
-
23
PsiBlast_CBE
90.00
55%
-96
- C7 -
3SEF
2
AROE_VIBCH
B:
[29-298]
I
D
Q
Y
A
V
F
G
---
N
H
S
K
S
P
F
I
H
T
----
L
F
A
R
Q
T
Q
Q
----
S
M
I
Y
T
A
Q
C
V
P
V
D
G
-
F
T
E
A
A
K
H
F
-
F
-
A
-----
Q
G
G
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
K
K
L
D
D
G
E
I
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
L
A
-
Q
-
Q
-
V
L
L
K
G
A
T
I
L
L
I
G
A
G
G
A
A
R
G
V
L
K
P
L
L
D
-
Q
Q
P
A
S
I
T
V
T
N
R
T
F
A
K
A
E
Q
L
A
E
L
V
A
A
Y
G
------
E
V
K
A
Q
A
F
-
E
Q
L
-
K
-
Q
-
S
Y
D
V
I
I
N
S
T
S
A
S
L
D
G
E
L
--
P
---
A
I
--
D
----
P
V
I
F
---
S
S
R
----
S
V
C
Y
D
M
M
Y
G
K
-
G
Y
T
V
F
N
Q
W
A
R
Q
H
G
C
A
Q
-
A
I
D
G
L
G
M
L
V
G
Q
A
A
E
S
F
M
L
W
R
G
L
R
P
G
T
K
Q
I
L
R
E
L
R
K
N
L
E
G
-
25
PsiBlast_CBE
89.35
55%
-95
- C7 -
3PGJ
1
AROE_VIBCH
C:
[29-298]
I
D
Q
Y
A
V
F
G
N
P
I
N
H
S
K
S
P
F
I
H
T
----
L
F
A
R
Q
T
Q
Q
----
S
M
I
Y
T
A
Q
C
V
P
V
D
G
-
F
T
E
A
A
K
H
F
-
F
-
A
-----
Q
G
G
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
K
K
L
D
D
G
E
I
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
L
A
-
Q
-
Q
-
V
L
L
K
G
A
T
I
L
L
I
G
A
G
G
A
A
R
G
V
L
K
P
L
L
D
-
Q
Q
P
A
S
I
T
V
T
N
R
T
F
A
K
A
E
Q
L
A
E
L
V
A
A
Y
G
------
E
V
K
A
Q
A
F
-
E
Q
L
-
K
-
Q
-
S
Y
D
V
I
I
N
S
T
S
---------
P
---
A
I
--
D
----
P
V
I
F
---
S
S
R
----
S
V
C
Y
D
M
M
Y
G
K
-
G
Y
T
V
F
N
Q
W
A
R
Q
H
G
C
A
Q
-
A
I
D
G
L
G
M
L
V
G
Q
A
A
E
S
F
M
L
W
R
G
L
R
P
G
T
K
Q
I
L
R
E
L
R
K
N
L
E
--
26
PsiBlast_CBE
88.84
55%
-96
- C7 -
3PGJ
1
AROE_VIBCH
B:
[29-298]
I
D
Q
Y
A
V
F
G
---
N
H
S
K
S
P
F
I
H
T
----
L
F
A
R
Q
T
Q
Q
----
S
M
I
Y
T
A
Q
C
V
P
V
D
G
-
F
T
E
A
A
K
H
F
-
F
-
A
-----
Q
G
G
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
K
K
L
D
D
G
E
I
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
L
A
-
Q
-
Q
-
V
L
L
K
G
A
T
I
L
L
I
G
A
G
G
A
A
R
G
V
L
K
P
L
L
D
-
Q
Q
P
A
S
I
T
V
T
N
R
T
F
A
K
A
E
Q
L
A
E
L
V
A
A
Y
G
------
E
V
K
A
Q
A
F
-
E
Q
L
-
K
-
Q
-
S
Y
D
V
I
I
N
S
T
S
A
S
L
D
G
E
L
--
P
---
A
I
--
D
----
P
V
I
F
---
S
S
R
----
S
V
C
Y
D
M
M
Y
G
K
-
G
Y
T
V
F
N
Q
W
A
R
Q
H
G
C
A
Q
-
A
I
D
G
L
G
M
L
V
G
Q
A
A
E
S
F
M
L
W
R
G
L
R
P
G
T
K
Q
I
L
R
E
L
R
K
N
L
E
--
65
HHSearch
88.68
54%
-101
- C7 -
3O8Q
5
?
A:
[8-279]
I
D
Q
Y
A
V
F
G
N
P
I
N
H
S
K
S
P
F
I
H
T
----
L
F
A
R
Q
T
Q
Q
----
S
M
I
Y
T
A
Q
C
V
P
V
D
G
-
F
T
E
A
A
K
H
F
-
F
A
Q
-----
G
G
-
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
K
K
L
D
D
G
E
I
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
-
L
-
A
-
Q
Q
V
L
L
K
G
A
T
I
L
L
I
G
A
G
G
A
A
R
G
V
L
K
P
L
L
D
-
Q
Q
P
A
S
I
T
V
T
N
R
T
F
A
K
A
E
Q
L
A
E
L
V
A
A
Y
G
------
E
V
K
A
Q
A
F
-
E
Q
L
-
K
-
Q
-
S
Y
D
V
I
I
N
S
T
S
A
S
----
L
--
P
---
A
I
-
D
P
----
V
I
F
S
---
S
-
R
----
S
V
C
Y
D
M
M
Y
G
K
-
G
Y
T
V
F
N
Q
W
A
R
Q
H
G
C
-
A
Q
A
I
D
G
L
G
M
L
V
G
Q
A
A
E
S
F
M
L
W
R
G
L
R
P
G
T
K
Q
I
L
R
E
L
R
K
N
L
E
G
A
67
HHSearch
88.41
53%
-94
- C7 -
1NYT
7
AROE_ECOLI
A:
[1-270]
M
E
T
Y
A
V
F
G
N
P
I
A
H
S
K
S
P
F
I
H
Q
----
Q
F
A
Q
Q
L
N
I
----
E
H
P
Y
G
R
V
L
A
P
I
N
D
-
F
I
N
T
L
N
A
F
-
F
S
A
-----
G
G
-
K
G
A
N
V
T
V
P
F
K
E
E
A
F
A
R
A
D
E
L
T
E
R
A
A
L
A
G
A
V
N
T
L
M
R
L
E
D
G
R
L
L
G
D
N
T
D
G
V
G
L
L
S
D
L
-
E
-
R
-
L
S
F
I
R
P
G
L
R
I
L
L
I
G
A
G
G
A
S
R
G
V
L
L
P
L
L
S
-
L
D
C
-
A
V
T
I
T
N
R
T
V
S
R
A
E
E
L
A
K
L
F
A
H
T
G
------
S
I
Q
A
L
S
M
-
D
E
L
E
G
-
H
-
E
F
D
L
I
I
N
A
T
S
S
G
I
S
G
D
I
--
P
---
A
I
-
P
S
----
S
L
I
H
---
P
-
G
----
I
Y
C
Y
D
M
F
Y
Q
K
-
G
K
T
P
F
L
A
W
C
E
Q
R
G
S
-
K
R
N
A
D
G
L
G
M
L
V
A
Q
A
A
H
A
F
L
L
W
H
G
V
L
P
D
V
E
P
V
I
K
Q
L
Q
E
E
L
S
--
4
PsiBlast_PDB
88.22
55%
-98
- C7 -
3O8Q
5
?
A:
[8-277]
I
D
Q
Y
A
V
F
G
N
P
I
N
H
S
K
S
P
F
I
H
T
----
L
F
A
R
Q
T
Q
Q
----
S
M
I
Y
T
A
Q
C
V
P
V
D
G
-
F
T
E
A
A
K
H
F
-
F
-
A
-----
Q
G
G
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
K
K
L
D
D
G
E
I
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
L
A
-
Q
-
Q
-
V
L
L
K
G
A
T
I
L
L
I
G
A
G
G
A
A
R
G
V
L
K
P
L
L
D
-
Q
Q
P
A
S
I
T
V
T
N
R
T
F
A
K
A
E
Q
L
A
E
L
V
A
A
Y
G
------
E
V
K
A
Q
A
F
-
E
Q
L
-
K
-
Q
-
S
Y
D
V
I
I
N
S
T
S
A
S
----
L
--
P
---
A
I
--
D
----
P
V
I
F
---
S
S
R
----
S
V
C
Y
D
M
M
Y
G
K
-
G
Y
T
V
F
N
Q
W
A
R
Q
H
G
C
A
Q
-
A
I
D
G
L
G
M
L
V
G
Q
A
A
E
S
F
M
L
W
R
G
L
R
P
G
T
K
Q
I
L
R
E
L
R
K
N
L
E
G
A
22
PsiBlast_CBE
87.73
55%
-102
- C7 -
3SEF
1
AROE_VIBCH
C:
[29-298]
I
D
Q
Y
A
V
F
G
N
P
I
N
H
S
K
S
P
F
I
H
T
----
L
F
A
R
Q
T
Q
Q
----
S
M
I
Y
T
A
Q
C
V
P
V
D
G
-
F
T
E
A
A
K
H
F
-
F
-
A
-----
Q
G
G
R
G
C
N
V
T
V
P
F
K
E
E
A
Y
R
F
A
D
R
L
T
E
R
A
R
L
A
G
A
V
N
T
L
K
K
-
D
D
G
E
I
L
G
D
N
T
D
G
E
G
L
V
Q
D
L
L
A
-
Q
-
Q
-
V
L
L
K
G
A
T
I
L
L
I
G
A
G
G
A
A
R
G
V
L
K
P
L
L
D
-
Q
Q
P
A
S
I
T
V
T
N
R
T
F
A
K
A
E
Q
L
A
E
L
V
A
A
Y
G
------
E
V
K
A
Q
A
F
-
E
Q
L
-
K
-
Q
-
S
Y
D
V
I
I
N
S
T
S
A
-------------
I
--
D
----
P
V
I
F
---
S
S
R
----
S
V
C
Y
D
M
M
Y
G
--------------------
I
D
G
L
G
M
L
V
G
Q
A
A
E
S
F
M
L
W
R
G
L
R
P
G
T
K
Q
I
L
R
E
L
R
K
N
L
E
--
6
PsiBlast_PDB
87.53
50%
-101
- C7 -
3PWZ
-
?
A:
[3-267]
-
D
R
Y
A
V
I
G
R
P
I
N
H
T
K
S
P
L
I
H
G
----
L
F
A
Q
A
S
N
Q
----
Q
L
E
Y
G
A
I
E
G
S
L
D
D
-
F
E
A
Q
V
L
Q
F
R
S
-
E
-----
G
G
-
K
G
M
N
I
T
A
P
F
K
L
R
A
F
E
L
A
D
R
R
S
E
R
A
Q
L
A
R
A
A
N
A
L
-
K
F
E
D
G
R
I
V
A
E
N
F
D
G
I
G
L
L
R
D
I
E
E
-
N
-
L
G
E
P
L
R
N
R
R
V
L
L
L
G
A
G
G
A
V
R
G
A
L
L
P
F
L
Q
-
A
G
P
S
E
L
V
I
A
N
R
D
M
A
K
A
L
A
L
R
N
E
L
-
D
H
S
------
R
L
R
I
S
R
Y
-
E
A
L
-
E
-
G
Q
S
F
D
I
V
V
N
A
T
S
A
S
L
T
A
D
L
--
P
---
P
L
-
P
A
----
D
V
L
G
---
E
A
-----
A
L
A
Y
E
L
A
Y
G
K
-
G
L
T
P
F
L
R
L
A
R
E
Q
G
Q
A
R
-
L
A
D
G
V
G
M
L
V
E
Q
A
A
E
A
F
A
W
W
R
G
V
R
P
D
T
R
A
V
I
N
Q
L
T
I
P
L
E
--
66
HHSearch
86.85
49%
-98
- C7 -
3PWZ
-
?
A:
[2-272]
S
D
R
Y
A
V
I
G
R
P
I
N
H
T
K
S
P
L
I
H
G
----
L
F
A
Q
A
S
N
Q
----
Q
L
E
Y
G
A
I
E
G
S
L
D
D
-
F
E
A
Q
V
L
Q
F
-
R
S
E
-----
G
G
-
K
G
M
N
I
T
A
P
F
K
L
R
A
F
E
L
A
D
R
R
S
E
R
A
Q
L
A
R
A
A
N
A
L
K
F
E
-
D
G
R
I
V
A
E
N
F
D
G
I
G
L
L
R
D
I
-
E
-
E
N
L
G
E
P
L
R
N
R
R
V
L
L
L
G
A
G
G
A
V
R
G
A
L
L
P
F
L
Q
-
A
G
P
S
E
L
V
I
A
N
R
D
M
A
K
A
L
A
L
R
N
E
L
D
H
S
-------
R
L
R
I
S
R
Y
-
E
A
L
E
G
-
Q
-
S
F
D
I
V
V
N
A
T
S
A
S
L
T
A
D
L
--
P
---
P
L
-
P
A
----
D
V
L
G
---
E
-
A
----
A
L
A
Y
E
L
A
Y
G
K
-
G
L
T
P
F
L
R
L
A
R
E
Q
G
Q
-
A
R
L
A
D
G
V
G
M
L
V
E
Q
A
A
E
A
F
A
W
W
R
G
V
R
P
D
T
R
A
V
I
N
Q
L
T
I
P
L
E
--
8
PsiBlast_PDB
85.20
44%
-99
- C7 -
1P77
2
AROE_HAEIN
A:
[1-271]
M
D
L
Y
A
V
W
G
N
P
I
A
Q
S
K
S
P
L
I
Q
N
----
K
L
A
A
Q
T
H
Q
----
T
M
E
Y
I
A
K
L
G
D
L
D
A
-
F
E
Q
Q
L
L
A
F
-
F
-
E
-----
E
G
A
K
G
C
N
I
T
S
P
F
K
E
R
A
Y
Q
L
A
D
E
Y
S
Q
R
A
K
L
A
E
A
C
N
T
L
K
K
L
D
D
G
K
L
Y
A
D
N
T
D
G
I
G
L
V
T
D
L
Q
R
-
L
-
N
W
L
R
-
P
N
Q
H
V
L
I
L
G
A
G
G
A
T
K
G
V
L
L
P
L
L
--
Q
A
Q
Q
N
I
V
L
A
N
R
T
F
S
K
T
K
E
L
A
E
R
F
Q
P
Y
G
------
N
I
Q
A
V
S
M
-
D
S
I
-
P
L
Q
-
T
Y
D
L
V
I
N
A
T
S
A
------------
S
V
-
D
A
----
E
I
L
K
---
L
G
-----
S
A
F
Y
D
M
Q
Y
A
K
G
T
D
T
P
F
I
A
L
C
K
S
L
G
L
T
N
-
V
S
D
G
F
G
M
L
V
A
Q
A
A
H
S
F
H
L
W
R
G
V
M
P
D
F
V
S
V
Y
E
Q
L
K
K
A
M
L
--
7
PsiBlast_PDB
83.08
44%
-95
- C7 -
1P74
-
AROE_HAEIN
A:
[1-271]
M
D
L
Y
A
V
W
G
N
P
I
A
Q
S
K
S
P
L
I
Q
N
----
K
L
A
A
Q
T
H
Q
----
T
M
E
Y
I
A
K
L
G
D
L
D
A
-
F
E
Q
Q
L
L
A
F
-
F
-
E
-----
E
G
A
K
G
C
N
I
T
S
P
F
K
E
R
A
Y
Q
L
A
D
E
Y
S
Q
R
A
K
L
A
E
A
C
N
T
L
K
K
L
D
D
G
K
L
Y
A
D
N
T
D
G
I
G
L
V
T
D
L
Q
R
-
L
-
N
W
L
R
-
P
N
Q
H
V
L
I
L
G
A
G
G
A
T
K
G
V
L
L
P
L
L
--
Q
A
Q
Q
N
I
V
L
A
N
R
T
F
S
K
T
K
E
L
A
E
R
F
Q
P
Y
G
------
N
I
Q
A
V
S
M
-
D
S
I
-
P
L
Q
-
T
Y
D
L
V
I
N
A
T
S
A
G
-------
A
---
S
V
-
D
A
----
E
I
L
K
---
L
G
-----
S
A
F
Y
D
M
Q
Y
A
K
G
T
D
T
P
F
I
A
L
C
K
S
L
G
L
T
N
-
V
S
D
G
F
G
M
L
V
A
Q
A
A
H
S
F
H
L
W
R
G
V
M
P
D
F
V
S
V
Y
E
Q
L
K
K
A
M
L
--
69
HHSearch
82.79
45%
-93
- C7 -
1P77
2
AROE_HAEIN
A:
[1-271]
M
D
L
Y
A
V
W
G
N
P
I
A
Q
S
K
S
P
L
I
Q
N
----
K
L
A
A
Q
T
H
Q
----
T
M
E
Y
I
A
K
L
G
D
L
D
A
-
F
E
Q
Q
L
L
A
F
-
F
E
E
-----
G
A
-
K
G
C
N
I
T
S
P
F
K
E
R
A
Y
Q
L
A
D
E
Y
S
Q
R
A
K
L
A
E
A
C
N
T
L
K
K
L
D
D
G
K
L
Y
A
D
N
T
D
G
I
G
L
V
T
D
L
-
Q
-
R
-
L
N
W
L
R
P
N
Q
H
V
L
I
L
G
A
G
G
A
T
K
G
V
L
L
P
L
L
Q
-
A
Q
Q
-
N
I
V
L
A
N
R
T
F
S
K
T
K
E
L
A
E
R
F
Q
P
Y
G
------
N
I
Q
A
V
S
M
D
S
I
P
-
L
-
Q
-
T
Y
D
L
V
I
N
A
T
S
A
------------
S
V
-
D
A
----
E
I
L
K
---
L
-
G
----
S
A
F
Y
D
M
Q
Y
A
K
G
T
D
T
P
F
I
A
L
C
K
S
L
G
L
-
T
N
V
S
D
G
F
G
M
L
V
A
Q
A
A
H
S
F
H
L
W
R
G
V
M
P
D
F
V
S
V
Y
E
Q
L
K
K
A
M
L
--
31
PsiBlast_CBE
73.68
36%
-94
- C7 -
2HK9
2
AROE_AQUAE
D:
[15-258]
---
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
----
A
L
I
R
Y
A
G
L
----
N
A
V
Y
L
A
----
F
E
I
-
N
P
E
E
L
K
K
A
-
F
-
E
GFKAL
K
V
-
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
-
V
K
F
E
N
G
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
K
S
-
L
-
I
P
-
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
A
L
V
K
-
E
G
-
A
K
V
F
L
W
N
R
T
K
E
K
A
I
K
L
A
Q
K
F
P
-
L
E
------
V
V
N
S
P
---
E
E
V
-
I
-
D
-
K
V
Q
V
I
V
N
T
T
S
V
G
L
K
D
E
D
--
P
---
E
I
-
F
N
----
Y
D
L
I
---
K
K
D
----
H
V
V
V
D
I
I
Y
K
E
---
T
K
L
L
K
K
A
K
E
K
G
-
A
K
-
L
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
P
Y
S
V
A
E
R
S
V
R
D
-----
71
HHSearch
72.63
30%
-92
- C7 -
1NVT
2
AROE_METJA
A:
[11-284]
T
K
V
I
G
L
I
G
H
P
V
E
H
S
F
S
P
I
M
H
N
----
A
A
F
K
D
K
G
L
----
N
Y
V
Y
V
A
F
D
V
L
P
E
N
-
L
K
Y
V
I
D
G
A
-
K
A
L
-----
G
I
-
V
G
F
N
V
T
I
P
H
K
I
E
I
M
K
Y
L
D
E
I
D
K
D
A
Q
L
I
G
A
V
N
T
I
K
I
E
-
D
G
K
A
I
G
Y
N
T
D
G
I
G
A
R
M
A
L
-
E
-
E
-
E
I
G
R
V
K
D
K
N
I
V
I
Y
G
A
G
G
A
A
R
A
V
A
F
E
L
A
K
-
D
N
--
N
I
I
I
A
N
R
T
V
E
K
A
E
A
L
A
K
E
I
A
E
K
L
NKKFGE
E
V
K
F
S
G
L
-
D
V
D
-
L
-
D
-
G
V
D
I
I
I
N
A
T
P
I
G
M
Y
P
N
I
DV
E
---
P
I
V
K
A
----
E
K
L
R
---
E
-
D
----
M
V
V
M
D
L
I
Y
N
P
-
L
E
T
V
L
L
K
E
A
K
K
V
N
A
-
K
-
T
I
N
G
L
G
M
L
I
Y
Q
G
A
V
A
F
K
I
W
T
G
V
E
P
N
I
E
V
M
K
N
A
I
I
D
K
I
T
K
-
33
PsiBlast_CBE
72.61
36%
-94
- C7 -
2HK9
2
AROE_AQUAE
B:
[15-258]
---
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
----
A
L
I
R
Y
A
G
L
----
N
A
V
Y
L
A
----
F
E
I
-
N
P
E
E
L
K
K
A
-
F
-
E
GFKAL
K
V
-
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
-
V
K
F
E
N
G
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
K
S
-
L
-
I
P
-
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
A
L
V
K
-
E
G
-
A
K
V
F
L
W
N
R
T
K
E
K
A
I
K
L
A
Q
K
F
P
-
L
E
------
V
V
N
S
P
---
E
E
V
-
I
-
D
-
K
V
Q
V
I
V
N
T
T
S
V
G
L
K
D
E
D
--
P
---
E
I
-
F
N
----
Y
D
L
I
---
K
K
D
----
H
V
V
V
D
I
I
Y
K
E
---
T
K
L
L
K
K
A
K
E
K
G
-
A
K
-
L
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
P
Y
S
V
A
E
R
S
V
R
D
L
----
11
PsiBlast_PDB
71.04
36%
-94
- C7 -
2HK9
3
AROE_AQUAE
A:
[15-258]
---
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
----
A
L
I
R
Y
A
G
L
----
N
A
V
Y
L
A
----
F
E
I
-
N
P
E
E
L
K
K
A
-
F
-
E
G
F
K
A
L
K
V
-
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
-
V
K
F
E
N
G
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
K
S
-
L
-
I
P
-
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
A
L
V
K
-
E
G
-
A
K
V
F
L
W
N
R
T
K
E
K
A
I
K
L
A
Q
K
F
P
-
L
E
------
V
V
N
S
P
---
E
E
V
-
I
-
D
-
K
V
Q
V
I
V
N
T
T
S
V
G
L
K
D
E
D
--
P
---
E
I
-
F
N
----
Y
D
L
I
---
K
K
D
----
H
V
V
V
D
I
I
Y
K
E
---
T
K
L
L
K
K
A
K
E
K
G
-
A
K
-
L
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
P
Y
S
V
A
E
R
S
V
R
D
L
R
G
--
40
PsiBlast_CBE
70.46
33%
-89
- C7 -
3PHJ
1
AROE_HELPY
A:
[3-260]
L
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
P
L
E
S
---
H
I
K
S
E
F
-
L
-
H
-----
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
V
-
L
E
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
K
----------
Y
Q
N
A
L
I
L
G
A
G
G
S
A
K
A
-
L
A
C
E
L
K
-
K
Q
G
L
Q
V
S
V
L
N
R
S
S
R
-
G
L
D
F
F
Q
R
---
L
G
------
C
--
D
C
F
M
-
E
P
P
-
K
-
S
-
A
F
D
L
I
I
N
A
T
S
-----
E
L
--
P
LN
K
E
V
-
L
K
----
G
Y
F
K
---
E
G
K
-----
L
A
Y
D
L
A
Y
G
--
F
L
T
P
F
L
S
L
A
K
E
L
K
T
P
F
-
Q
-
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
A
S
Q
I
P
Y
S
K
A
F
E
V
M
R
S
V
F
---
32
PsiBlast_CBE
70.41
36%
-95
- C7 -
2HK9
2
AROE_AQUAE
C:
[15-258]
---
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
----
A
L
I
R
Y
A
G
L
----
N
A
V
Y
L
A
----
F
E
I
-
N
P
E
E
L
K
K
A
-
F
-
E
GFKAL
K
V
-
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
-
V
K
F
E
N
G
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
K
S
-
L
-
I
P
-
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
A
L
V
K
-
E
G
-
A
K
V
F
L
W
N
R
T
K
E
K
A
I
K
L
A
Q
K
F
P
-
L
E
------
V
V
N
S
P
---
E
E
V
-
I
-
D
-
K
V
Q
V
I
V
N
T
T
S
V
G
L
K
D
E
D
--
P
---
E
I
-
F
N
----
Y
D
L
I
---
K
K
D
----
H
V
V
V
D
I
I
Y
K
E
---
T
K
L
L
K
K
A
K
E
K
G
-
A
K
-
L
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
P
Y
S
V
A
E
R
S
V
R
D
-----
16
PsiBlast_PDB
70.25
34%
-81
- C7 -
2D5C
4
AROE_THET8
A:
[1-261]
M
L
R
F
A
V
L
G
H
P
V
A
H
S
L
S
P
A
M
H
A
----
F
A
L
E
S
L
G
L
----
E
G
S
Y
E
A
W
D
T
P
L
E
A
-
L
P
G
R
L
K
E
V
-
R
-
R
-----
A
F
-
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
L
Q
V
-
E
G
R
L
F
G
F
N
T
D
A
P
G
F
L
E
A
L
K
A
-
G
--
G
I
P
L
K
G
P
A
L
V
L
G
A
G
G
A
G
R
A
V
A
F
A
--
L
R
-
E
A
G
L
E
V
W
V
W
N
R
T
P
Q
R
A
L
A
L
A
E
E
F
G
-
L
R
------
A
V
P
L
E
K
A
-
R
E
A
-
R
------
L
L
V
N
A
T
R
V
G
L
E
D
P
S
--
A
---
S
P
-
L
P
----
A
E
L
F
---
P
E
E
----
G
A
A
V
D
L
V
Y
R
P
-
L
W
T
R
F
L
R
E
A
K
A
K
G
-
L
K
-
V
Q
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
P
D
P
S
G
M
E
E
A
A
R
R
A
L
---
76
HHSearch
69.73
35%
-87
* C7 *
2HK9
3
AROE_AQUAE
A:
[12-271]
T
Q
L
Y
G
V
I
G
F
P
V
K
H
S
L
S
P
V
F
Q
N
----
A
L
I
R
Y
A
G
L
----
N
A
V
Y
L
A
F
E
I
N
P
E
E
-
L
K
K
A
F
E
G
F
-
K
A
L
-----
K
V
-
K
G
I
N
V
T
V
P
F
K
E
E
I
I
P
L
L
D
Y
V
E
D
T
A
K
E
I
G
A
V
N
T
V
K
F
E
-
N
G
K
A
Y
G
Y
N
T
D
W
I
G
F
L
K
S
L
-
K
-
S
-
L
I
P
E
V
K
E
K
S
I
L
V
L
G
A
G
G
A
S
R
A
V
I
Y
A
L
V
K
-
E
G
A
-
K
V
F
L
W
N
R
T
K
E
K
A
I
K
L
A
Q
K
F
P
L
E
---------
V
V
N
S
P
-
E
E
V
-
I
-
D
-
K
V
Q
V
I
V
N
T
T
S
V
G
L
K
D
E
D
P-
E
---
I
F
-
N
Y
----
D
L
I
K
---
K
-
D
----
H
V
V
V
D
I
I
Y
K
---
E
T
K
L
L
K
K
A
K
E
K
G
A
-
K
-
L
L
D
G
L
P
M
L
L
W
Q
G
I
E
A
F
K
I
W
N
G
C
E
V
P
Y
S
V
A
E
R
S
V
R
D
L
R
G
--
36
PsiBlast_CBE
69.72
34%
-83
- C7 -
2D5C
3
AROE_THET8
B:
[1-261]
M
L
R
F
A
V
L
G
H
P
V
A
H
S
L
S
P
A
M
H
A
----
F
A
L
E
S
L
G
L
----
E
G
S
Y
E
A
W
D
T
P
L
E
A
-
L
P
G
R
L
K
E
V
-
R
-
R
-----
A
F
-
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
L
Q
V
-
E
G
R
L
F
G
F
N
T
D
A
P
G
F
L
E
A
L
K
A
-
G
--
G
I
P
L
K
G
P
A
L
V
L
G
A
G
G
A
G
R
A
V
A
F
A
--
L
R
-
E
A
G
L
E
V
W
V
W
N
R
T
P
Q
R
A
L
A
L
A
E
E
F
G
-
L
R
------
A
V
P
L
E
K
A
-
R
E
A
-
R
------
L
L
V
N
A
T
R
V
G
L
------
A
---
S
P
-
L
P
----
A
E
L
F
---
P
E
E
----
G
A
A
V
D
L
V
Y
R
P
-
L
W
T
R
F
L
R
E
A
K
A
K
G
-
L
K
-
V
Q
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
P
D
P
S
G
M
E
E
A
A
R
R
A
L
G
V
-
46
PsiBlast_CBE
69.58
32%
-82
- C7 -
4FR5
1
AROE_HELPY
B:
[3-260]
L
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
ACFL
T
F
Q
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
P
L
E
S
---
H
I
K
S
E
F
-
L
-
H
-----
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
V
-
L
E
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
K
Q
-
K
------
N
Y
Q
N
A
L
I
L
G
A
G
G
S
A
K
A
-
L
A
C
E
L
K
-
K
Q
G
L
Q
V
S
V
L
N
R
S
S
R
-
G
L
D
F
F
Q
R
---
L
G
------
C
--
D
C
F
M
-
E
P
P
-
K
-
S
-
A
F
D
L
I
I
N
A
T
S
A
S
L
H
N
E
L
--
P
LNK
E
V
-
L
K
----
G
Y
F
K
---
E
G
K
-----
L
A
Y
D
L
A
-
S
G
-
F
L
T
P
F
L
S
L
A
K
E
L
K
T
P
F
-
Q
-
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
A
S
Q
I
P
Y
S
K
A
F
E
V
M
R
S
V
F
---
42
PsiBlast_CBE
69.56
33%
-84
- C7 -
3PHI
2
AROE_HELPY
A:
[3-260]
L
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
P
L
E
S
---
H
I
K
S
E
F
-
L
-
H
-----
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
V
-
L
E
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
K
----------
Y
Q
N
A
L
I
L
G
A
G
G
S
A
K
A
-
L
A
C
E
L
K
-
K
Q
G
L
Q
V
S
V
L
N
R
S
S
R
-
G
L
D
F
F
Q
R
---
L
G
------
C
--
D
C
F
M
-
E
P
P
-
K
-
S
-
A
F
D
L
I
I
N
A
T
S
A
S
L
H
N
E
L
--
P
LN
K
E
V
-
L
K
----
G
Y
F
K
---
E
G
K
-----
L
A
Y
D
L
A
Y
G
--
F
L
T
P
F
L
S
L
A
K
E
L
K
T
P
F
-
Q
-
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
A
S
Q
I
P
Y
S
K
A
F
E
V
M
R
S
V
----
43
PsiBlast_CBE
69.10
33%
-79
- C7 -
4FQ8
1
AROE_HELPY
B:
[3-260]
L
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
ACFL
T
F
Q
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
P
L
E
S
---
H
I
K
S
E
F
-
L
-
H
-----
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
V
-
L
E
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
K
Q
-
K
------
N
Y
Q
N
A
L
I
L
G
A
G
G
S
A
K
A
-
L
A
C
E
L
K
-
K
Q
G
L
Q
V
S
V
L
N
R
S
S
R
-
G
L
D
F
F
Q
R
---
L
G
------
C
--
D
C
F
M
-
E
P
P
-
K
-
S
-
A
F
D
L
I
I
N
A
T
S
A
S
L
H
N
E
L
--
P
LNK
E
V
-
L
K
----
G
Y
F
K
---
E
G
K
-----
L
A
Y
D
L
A
-
A
G
-
F
L
T
P
F
L
S
L
A
K
E
L
K
T
P
F
-
Q
-
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
A
S
Q
I
P
Y
S
K
A
F
E
V
M
R
S
V
F
---
35
PsiBlast_CBE
68.98
34%
-80
- C7 -
2EV9
2
AROE_THET8
B:
[1-261]
M
L
R
F
A
V
L
G
H
P
V
A
H
S
L
S
P
A
M
H
A
----
F
A
L
E
S
L
G
L
----
E
G
S
Y
E
A
W
D
T
P
L
E
A
-
L
P
G
R
L
K
E
V
-
R
-
R
-----
A
F
-
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
L
Q
V
-
E
G
R
L
F
G
F
N
T
D
A
P
G
F
L
E
A
L
K
A
-
G
--
G
I
P
L
K
G
P
A
L
V
L
G
A
G
G
A
G
R
A
V
A
F
A
--
L
R
-
E
A
G
L
E
V
W
V
W
N
R
T
P
Q
R
A
L
A
L
A
E
E
F
G
-
L
R
------
A
V
P
L
E
K
A
-
R
E
A
-
R
------
L
L
V
N
A
T
R
V
G
L
E
D
P
S
--
A
---
S
P
-
L
P
----
A
E
L
F
---
P
E
E
----
G
A
A
V
D
L
V
Y
R
P
-
L
W
T
R
F
L
R
E
A
K
A
K
G
-
L
K
-
V
Q
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
P
D
P
S
G
M
E
E
A
A
R
R
A
L
G
V
-
44
PsiBlast_CBE
68.87
33%
-77
- C7 -
4FQ8
1
AROE_HELPY
A:
[3-260]
L
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
P
L
E
S
---
H
I
K
S
E
F
-
L
-
H
-----
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
V
-
L
E
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
K
Q
-
K
------
N
Y
Q
N
A
L
I
L
G
A
G
G
S
A
K
A
-
L
A
C
E
L
K
-
K
Q
G
L
Q
V
S
V
L
N
R
S
S
R
-
G
L
D
F
F
Q
R
---
L
G
------
C
--
D
C
F
M
-
E
P
P
-
K
-
S
-
A
F
D
L
I
I
N
A
T
S
A
S
L
H
N
E
L
--
P
LN
K
E
V
-
L
K
----
G
Y
F
K
---
E
G
K
-----
L
A
Y
D
L
A
-
A
G
-
F
L
T
P
F
L
S
L
A
K
E
L
K
T
P
F
-
Q
-
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
A
S
Q
I
P
Y
S
K
A
F
E
V
M
R
S
V
F
---
17
PsiBlast_PDB
68.87
34%
-79
- C7 -
2EV9
3
AROE_THET8
A:
[1-261]
M
L
R
F
A
V
L
G
H
P
V
A
H
S
L
S
P
A
M
H
A
----
F
A
L
E
S
L
G
L
----
E
G
S
Y
E
A
W
D
T
P
L
E
A
-
L
P
G
R
L
K
E
V
-
R
-
R
-----
A
F
-
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
L
Q
V
-
E
G
R
L
F
G
F
N
T
D
A
P
G
F
L
E
A
L
K
A
-
G
--
G
I
P
L
K
G
P
A
L
V
L
G
A
G
G
A
G
R
A
V
A
F
A
--
L
R
-
E
A
G
L
E
V
W
V
W
N
R
T
P
Q
R
A
L
A
L
A
E
E
F
G
-
L
R
------
A
V
P
L
E
K
A
-
R
E
A
-
R
------
L
L
V
N
A
T
R
V
G
L
E
D
P
S
--
A
---
S
P
-
L
P
----
A
E
L
F
---
P
E
E
----
G
A
A
V
D
L
V
Y
R
P
-
L
W
T
R
F
L
R
E
A
K
A
K
G
-
L
K
-
V
Q
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
P
D
P
S
G
M
E
E
A
A
R
R
A
L
---
13
PsiBlast_PDB
68.75
32%
-90
- C7 -
3DOO
1
AROE_STAEQ
A:
[2-252]
--
K
F
A
V
I
G
N
P
I
S
H
S
L
S
P
L
M
H
H
----
A
N
F
Q
S
L
N
L
----
E
N
T
Y
E
A
I
N
V
P
V
N
Q
-
F
Q
D
I
K
K
I
I
-
S
-
E
-----
K
S
I
D
G
F
N
V
T
I
P
H
K
E
R
I
I
P
Y
L
D
D
I
N
E
Q
A
K
S
V
G
A
V
N
T
V
L
-
V
K
D
G
K
W
I
G
Y
N
T
D
G
I
G
Y
V
N
G
L
K
Q
I
Y
-
E
G
I
E
--
D
A
Y
I
L
I
L
G
A
G
G
A
S
K
G
I
A
N
E
L
Y
K
-
I
V
R
P
T
L
T
V
A
N
R
T
M
S
R
F
N
N
W
S
L
N
I
N
K
I
N
------
L
S
H
A
E
S
H
-
L
D
------
E
F
D
I
I
I
N
T
T
P
-----------------------
V
I
S
---
L
N
R
LASH
T
L
V
S
D
I
V
Y
N
P
-
Y
K
T
P
I
L
I
E
A
E
Q
R
G
N
P
--
I
Y
N
G
L
D
M
F
V
H
Q
G
A
E
S
F
K
I
W
T
N
L
E
P
D
I
K
A
M
K
N
I
V
I
Q
K
L
K
G
-
20
PsiBlast_PDB
68.70
33%
-84
- C7 -
3PHH
1
AROE_HELPY
A:
[3-260]
L
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
P
L
E
S
---
H
I
K
S
E
F
-
L
-
H
-----
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
V
-
L
E
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
K
----------
Y
Q
N
A
L
I
L
G
A
G
G
S
A
K
A
-
L
A
C
E
L
K
-
K
Q
G
L
Q
V
S
V
L
N
R
S
S
R
-
G
L
D
F
F
Q
R
---
L
G
------
C
--
D
C
F
M
-
E
P
P
-
K
-
S
-
A
F
D
L
I
I
N
A
T
S
A
S
L
H
N
E
L
--
P
LN
K
E
V
-
L
K
----
G
Y
F
K
---
E
G
K
-----
L
A
Y
D
L
A
Y
G
--
F
L
T
P
F
L
S
L
A
K
E
L
K
T
P
F
-
Q
-
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
A
S
Q
I
P
Y
S
K
A
F
E
V
M
R
S
V
F
---
64
HHSearch
68.54
36%
-76
- C7 -
2D5C
4
AROE_THET8
A:
[1-261]
M
L
R
F
A
V
L
G
H
P
V
A
H
S
L
S
P
A
M
H
A
----
F
A
L
E
S
L
G
L
----
E
G
S
Y
E
A
W
D
T
P
L
E
A
-
L
P
G
R
L
K
E
V
-
R
-
R
-----
A
F
-
R
G
V
N
L
T
L
P
L
K
E
A
A
L
A
H
L
D
W
V
S
P
E
A
Q
R
I
G
A
V
N
T
V
L
Q
V
-
E
G
R
L
F
G
F
N
T
D
A
P
G
F
L
E
A
L
-
K
-
A
-
G
G
I
P
-
L
K
G
P
A
L
V
L
G
A
G
G
A
G
R
A
V
A
F
A
L
R
E
-
A
G
L
-
E
V
W
V
W
N
R
T
P
Q
R
A
L
A
L
A
E
E
F
G
L
----------
R
A
V
P
L
--
E
K
-
A
-
R
-
E
A
R
L
L
V
N
A
T
R
V
G
L
E
D
P
S
A-
S
---
P
L
-
P
A
----
E
L
F
P
---
E
-
E
----
G
A
A
V
D
L
V
Y
R
P
-
L
W
T
R
F
L
R
E
A
K
A
K
G
L
-
K
-
V
Q
T
G
L
P
M
L
A
W
Q
G
A
L
A
F
R
L
W
T
G
L
L
P
D
P
S
G
M
E
E
A
A
R
R
A
L
---
39
PsiBlast_CBE
68.18
33%
-88
- C7 -
3PHJ
1
AROE_HELPY
B:
[3-260]
L
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
ACFL
T
F
Q
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
P
L
E
S
---
H
I
K
S
E
F
-
L
-
H
-----
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
V
-
L
E
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
K
----------
Y
Q
N
A
L
I
L
G
A
G
G
S
A
K
A
-
L
A
C
E
L
K
-
K
Q
G
L
Q
V
S
V
L
N
R
S
S
R
-
G
L
D
F
F
Q
R
---
L
G
------
C
--
D
C
F
M
-
E
P
P
-
K
-
S
-
A
F
D
L
I
I
N
A
T
S
-----
E
L
--
P
LNK
E
V
-
L
K
----
G
Y
F
K
---
E
G
K
-----
L
A
Y
D
L
A
Y
G
--
F
L
T
P
F
L
S
L
A
K
E
L
K
T
P
F
-
Q
-
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
A
S
Q
I
P
Y
S
K
A
F
E
V
M
R
S
V
F
---
48
PsiBlast_CBE
67.88
32%
-76
- C7 -
4FSH
1
AROE_HELPY
A:
[3-260]
L
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
K
L
G
F
----
L
G
H
Y
R
P
I
L
L
P
L
E
S
---
H
I
K
N
E
F
-
L
-
H
-----
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
A
S
I
N
T
L
V
-
L
E
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
K
H
-
Q
------
N
Y
Q
N
A
L
I
L
G
S
G
G
S
A
K
A
-
L
A
C
G
L
K
-
K
Q
G
L
K
V
S
V
L
N
R
S
P
R
-
G
L
D
F
F
Q
R
---
L
G
------
C
--
D
C
F
M
-
E
P
P
-
K
-
S
-
A
F
D
L
I
I
N
A
T
S
A
S
L
N
---------
P
L
-
N
K
----
E
V
L
K
G
Y
F
K
E
A
----
K
L
A
Y
D
L
A
Y
G
--
F
L
T
P
F
L
A
L
A
K
E
L
K
I
P
F
-
Q
-
D
G
K
D
M
L
I
Y
Q
A
S
L
S
F
E
K
F
S
A
S
Q
I
P
Y
S
K
A
F
E
V
M
R
S
V
F
---
41
PsiBlast_CBE
67.17
33%
-81
- C7 -
3PHI
2
AROE_HELPY
B:
[3-260]
L
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
ACFL
T
F
Q
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
P
L
E
S
---
H
I
K
S
E
F
-
L
-
H
-----
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
V
-
L
E
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
K
----------
Y
Q
N
A
L
I
L
G
A
G
G
S
A
K
A
-
L
A
C
E
L
K
-
K
Q
G
L
Q
V
S
V
L
N
R
S
S
R
-
G
L
D
F
F
Q
R
---
L
G
------
C
--
D
C
F
M
-
E
P
P
-
K
-
S
-
A
F
D
L
I
I
N
A
T
S
A
S
L
H
N
E
L
--
P
LNK
E
V
-
L
K
----
G
Y
F
K
---
E
G
K
-----
L
A
Y
D
L
A
Y
G
--
F
L
T
P
F
L
S
L
A
K
E
L
K
T
P
F
-
Q
-
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
A
S
Q
I
P
Y
S
K
A
F
E
V
M
R
S
V
----
47
PsiBlast_CBE
67.12
32%
-75
- C7 -
4FR5
1
AROE_HELPY
A:
[3-260]
L
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
P
L
E
S
---
H
I
K
S
E
F
-
L
-
H
-----
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
V
-
L
E
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
K
Q
-
K
------
N
Y
Q
N
A
L
I
L
G
A
G
G
S
A
K
A
-
L
A
C
E
L
K
-
K
Q
G
L
Q
V
S
V
L
N
R
S
S
R
-
G
L
D
F
F
Q
R
---
L
G
------
C
--
D
C
F
M
-
E
P
P
-
K
-
S
-
A
F
D
L
I
I
N
A
T
S
A
S
L
H
N
E
L
--
P
LN
K
E
V
-
L
K
----
G
Y
F
K
---
E
G
K
-----
L
A
Y
D
L
A
-
S
G
-
F
L
T
P
F
L
S
L
A
K
E
L
K
T
P
F
-
Q
-
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
A
S
Q
I
P
Y
S
K
A
F
E
V
M
R
S
V
F
---
45
PsiBlast_CBE
66.63
32%
-80
- C7 -
4FOS
1
AROE_HELPY
A:
[3-260]
L
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
A
C
F
L
T
F
Q
K
E
L
R
F
----
L
G
H
Y
H
P
I
L
L
P
L
E
S
---
H
I
K
S
E
F
-
L
-
H
-----
L
G
L
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
V
-
L
E
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
K
Q
-
K
------
N
Y
Q
N
A
L
I
L
G
A
G
G
S
A
K
A
-
L
A
C
E
L
K
-
K
Q
G
L
Q
V
S
V
L
N
R
S
S
R
-
G
L
D
F
F
Q
R
---
L
G
------
C
--
D
C
F
M
-
E
P
P
-
K
-
S
-
A
F
D
L
I
I
N
A
T
S
A
S
L
H
N
E
L
--
P
LN
K
E
V
-
L
K
----
G
Y
F
K
---
E
G
K
-----
L
A
Y
D
L
A
Y
G
--
F
L
T
P
F
L
S
L
A
K
E
L
K
T
P
F
-
Q
-
D
G
K
D
M
L
I
Y
A
A
A
L
S
F
E
K
F
S
A
S
Q
I
P
Y
S
K
A
F
E
V
M
R
S
V
F
---
75
HHSearch
66.22
33%
-70
- C7 -
3PHH
1
AROE_HELPY
A:
[3-261]
L
K
S
F
G
V
F
G
N
P
I
K
H
S
K
S
P
L
I
H
N
----
A
C
F
L
T
F
Q
K
ELR
F
L
G
H
Y
H
P
I
L
L
P
L
E
S
H
I
K
S
E
F
L
H
----
L
-----
G
L
-
S
G
A
N
V
T
L
P
F
K
E
R
A
F
Q
V
C
D
K
I
K
G
I
A
L
E
C
G
A
V
N
T
L
V
L
E
-
N
D
E
L
V
G
Y
N
T
D
A
L
G
F
Y
L
S
L
-
K
---------
Y
Q
N
A
L
I
L
G
A
G
G
S
A
K
A
L
A
C
E
L
K
K
-
Q
G
L
-
Q
V
S
V
L
N
R
S
S
R
G
L
D
F
-
F
Q
R
L
G
C
D
---------
C
F
M
---
E
P
P
-
K
-
S
-
A
F
D
L
I
I
N
A
T
S
A
S
L
H
N
E
L
------
P
L
-
N
K
E
V
L
K
G
Y
F
K
---
E
-
G
----
K
L
A
Y
D
L
A
Y
G
F
-
L
-
T
P
F
L
S
L
A
K
E
L
K
T
-
P
-
F
Q
D
G
K
D
M
L
I
Y
Q
A
A
L
S
F
E
K
F
S
A
S
Q
I
P
Y
S
K
A
F
E
V
M
R
S
V
F
---