@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0031: (2015-12-18 )
MKTSPNILFIMADQMAAPLLPLHDPRSVLRMPHLSRLAERAVVFDSAYCNSPLCAPSRFTLVSGRLPTRIGAWDNAADFAADTPTYAHYLRNLGYRTALSGKMHFCGPDQLHGYEERLTSDIYPADYGWAVNWDEPEVRPSWYHNMSSVLQAGPCVRTNQLDFDEEVVFKARQYLYDHVRQHAGQPFCLTVSMTHPHDPYSIPASYWNLYRDEDIPLPRQRFAQEEQDPHSQRLLKVIDLWDKPLPEERIRAARRAYFGACSYVDAQIGALLATLEKCGLADDTIVVFSGDHGDMLGERGLWYKMHWFEMAARVPLLVHAPARFAPRRIGASVSTVDLLPTLVELAGGQVDPRLPLEGRSLLPHLRDGSGHDEVIGEYTAEGTLSPLMMIRRGDYKFIYSEQDPCLLYDLRNDPQERENLAASPAHRGTFEAFLDEARRRWDIPAITRAVLDSQRRRRLVAAALARGRLASWDHQPWVDASQQYMRNHIDLDDLERRARFPQP
Atome Classification :
(20 SA)
.........10........20-.........30........40--.---.......50-.--.......60.--.......70--....--------...------.80---.---.------------------......90----------.-........100...----------------------.------------------------.-.--------------------..---------110------.---....------....120--......-...-----130..----.-...----..-----140--..-----.....150---------------------...-------....160.......170.......180.......190.......200........210....--..----.220-...------.....----------230.......--240..------------.....250-------...--.-----....260.......270.......280.......290.--------------.-..----------------...-300--------------------------------------------------------------------------.-----.-------------.-..--------------.--.--------..--310---------------.......320---.--.-.....330--.-.-.--...-...340.......-----------350.....--..360...---.---...370.-------------.---.---..-.-.----.---.-380.--.-.-----------.....---------------.390......-.----400.-.-..--...410.......420.......430.......440.......450.......460.......470.......480.......490.......500.
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKTSP
N
I
L
F
I
MADQMAAPLL--PLH
D
P
R
S
V
L
R
M
P
H
L
S
R
L
A
E
R
A
--
V
---
V
FDSAYCNS-P--LCAPS
R
F
T
L
V--SGRLPTRIG--AWDN--------
A
A
D------FAA---D---T------------------
P
T
Y
A
H
Y
L
-----------
R
-NLGYRTALS-GKMH----------------------F------------------------C-
G
--------------------
P
D
---------
Q
--------L---
H
G
Y
E
------
E
R
L
TS----DIYPAD-YGW-----A-VNW----D-EPE----V
R
-----
P
S
W
--
Y
H
-----
N
M
S
S
V
L
QA---------------------GPC-------VRTNQLDF
D
E
E
V
V
F
K
A
R
Q
Y
L
Y
D
H
V
R
Q
HAGQ
P
F
C
L
T
V
SMTHPHDPYS-I
P
A
S
Y
W
N
LYRDEDIP--L
P
----
R
Q
R
--
F
A
Q
------EEQD
P
----------
H
S
Q
R
L
L
K
V
I
D
--LWDKP------------L
P
E
E
R
I
R
--------
A
A
R
--
R
-----
A
Y
F
GA
C
S
Y
V
D
A
Q
I
G
A
L
L
A
T
L
E
KCGLAD
D
T
I
V
V
F
SGDHG--------------D-ML----------------GER-G----------------------------------------------------------------------------
L
-----
W
-------------
Y
-
K
M
--------------
H
--
W
--------
F
E
--
M
A
A---------------RV
P
L
L
V
HAPA---R--F-
A
P
R
R
IG----A-S-V--
S
T
V
-
D
L
L
P
T
L
V
E
LAGGQ-----------VDPRLPLE--G
R
S
LLPHL---R---DGSG--H-------------
D
---
E
---
V
I
-
G
-
E
----Y---T-A--E--G-T-----------
L
S
P
L
M
---------------
M
IRRG
D
Y
K
F
I
-Y----SEQD-
P
-
C
L
--
L
Y
DLRN
D
P
Q
E
R
E
NLAASPAHR
G
T
F
E
A
F
L
D
E
A
R
RRWD
I
P
A
I
T
R
A
V
L
D
S
Q
R
R
R
R
L
V
A
A
A
L
ARGRLASWDHQPW
V
D
A
S
Q
Q
Y
M
R
NHI
D
L
D
D
L
E
R
RARFPQP
1
PsiBlast_PDB
93.69
29%
-95
- C3 -
4UPL
1
?
A:
[19-509]
-----
N
I
L
F
I
M
F
D
Q
L
R
W
D
Y
L
--
S
C
Y
G
H
K
T
-
L
N
T
P
H
I
D
R
L
A
A
K
G
--
V
---
R
F
D
R
A
Y
I
Q
S
-
P
--
I
C
G
S
S
R
M
S
T
Y
--
T
G
R
Y
V
H
S
H
G
--
A
S
W
N
--------
G
I
P
------
L
K
V
---
G
---
E
------------------
M
T
M
G
D
H
L
-----------
R
-
A
A
G
M
G
C
W
L
V
-
G
K
T
H
----------------------
M
RAD
E
E
G
M
A
R
L
GLEPDS
L
I
G
A
R
V
A
E
C
-
G
FDVFERDDG
M
L
P
E
G
PDGYYD
P
D
---------
G
--------
A
---
K
E
Y
N
------
K
F
L
R
A
----
K
G
Y
E
S
D
-
N
P
W
HDFAN
S
-
G
L
D
----
D
-
E
G
N
----
V
Q
-----
S
G
W
--
F
L
-----
K
N
A
T
R
-----------------------------------
P
A
N
I
A
E
E
D
S
E
T
P
Y
L
T
S
R
A
M
-
E
F
I
E
Q
Q
T
G
-
P
W
C
C
H
L
S
Y
I
K
P
H
W
P
Y
I
-
V
P
E
P
Y
A
S
M
F
G
P
E
H
V
Q
---
D
----
V
V
R
--
S
D
S
------
E
R
Q
N
A
----------
H
P
--
L
F
K
A
----
F
M
D
T
K
------------
V
G
E
A
F
S
R
--------
Q
E
V
--
R
D
A
V
I
P
A
Y
M
G
L
I
K
Q
A
D
D
Q
M
G
R
L
F
K
W
L
E
D
T
G
R
M
Q
D
T
M
I
V
L
T
S
D
H
G
--------------
D
-
F
L
----------------
G
D
H
-
W
----------------------------------------------------------------------------
M
-----
G
-------------
E
-
K
T
--------------
F
--
F
--------
H
D
--
A
S
T
---------------
R
V
P
L
I
I
Y
D
P
R
---
P
--
E
-
A
D
A
T
R
G
SVCD
A
-
L
-
V
--
E
S
I
-
D
L
A
P
T
F
V
E
A
A
G
G
K
-----------
P
A
M
H
I
-
L
E
--
G
E
S
L
I
P
I
L
H
GA
R
---
D
H
T
L
--
R
-------------
D
---
H
---
V
I
-
C
-
E
----
Y
---
D
-
F
--
S
--
A
-
S
P
I
A
H
L
N
DISVR
Q
A
V
M
F
---------------
M
V
A
D
K
N
W
K
L
I
-
H
----
F
E
A
D
-
P
R
P
M
--
L
F
D
L
K
N
D
P
Q
E
L
V
D
L
G
G
D
P
A
H
A
D
V
I
A
G
M
Y
D
K
L
F
R
W
T
R
R
Q
S
Q
R
T
T
R
S
E
E
Q
L
I
A
M
R
T
K
S
R
K
R
G
I
V
L
G
I
Y
D
E
N
E
T
P
L
E
L
T
V
K
Y
R
D
R
K
A
R
P
Y
K
D
Y
L
K
G
----
2
PsiBlast_PDB
86.66
25%
-87
- C3 -
4UPK
-
?
A:
[33-498]
---
Q
S
N
V
L
F
I
I
I
D
Q
L
R
A
D
C
L
WG
A
L
A
D
---
H
V
E
L
P
H
L
R
A
L
A
Q
D
A
--
V
---
S
F
R
R
H
Y
S
V
T
-
N
--
P
C
G
P
S
R
A
S
I
L
--
T
G
Q
Y
A
M
N
H
R
--
S
V
R
N
--------
G
T
P
------
L
R
H
---
D
---
T
------------------
P
N
I
A
T
E
M
-----------
R
-
K
A
G
Y
L
P
L
L
F
-
G
Y
T
D
----------------------
T
------------------------
S
Q
D
--------------------
P
R
---------
A
--------
Y
---
D
A
N
D
------
P
A
L
K
T
----
Y
E
F
P
M
R
-
G
F
H
-----
E
-
V
T
E
----
M
-
R
L
E
----
M
S
-----
Y
P
W
--
Q
S
-----
H
L
K
N
R
G
Y
A
FDD
Y
A
Q
V
Y
VPRPDADGTPRLN
G
P
A
-------
M
Y
R
A
E
---
D
S
D
T
A
F
L
T
D
Q
F
L
A
N
-
M
P
A
W
A
G
Q
N
W
F
A
H
L
T
Y
I
R
P
H
P
P
L
V
-
A
P
A
P
Y
N
T
M
Y
D
P
A
K
L
P
--
L
P
----
A
R
L
--
P
G
R
------
D
D
E
T
A
E
HP
F
F
G
P
A
T
R
Y
S
S
P
A
S
F
V
L
G
--
F
P
D
L
E
------------
P
T
D
E
T
I
Q
--------
T
L
R
--
A
-----
V
Y
L
G
L
A
T
E
V
D
T
H
I
G
R
V
I
A
H
L
K
E
T
G
Q
Y
D
D
T
L
I
V
V
T
A
D
H
G
--------------
E
-
M
L
----------------
G
D
R
-
H
----------------------------------------------------------------------------
S
-----
W
-------------
G
-
K
M
--------------
T
--
V
--------
Y
D
--
A
A
Y
---------------
H
T
P
L
I
I
R
A
P
G
---
C
--
K
-
P
G
H
V
V
E
----
A
-
P
-
T
--
E
S
I
-
D
L
M
P
T
I
L
D
W
V
G
Q
E
-----------
I
P
N
A
--
V
D
--
G
R
S
L
R
P
F
L
---
T
---
G
E
A
P
--
S
-------------
D
WRQ
Y
---
S
F
-
S
-
E
----
L
---
D
-
I
--
S
--
E
-
P
-----------
L
D
P
T
L
W
Q
Q
E
F
GFGPSAG
A
V
A
I
L
R
D
A
R
F
T
L
V
-
E
----
F
A
A
D
L
P
-
P
M
--
L
F
D
H
Q
G
E
G
E
F
R
-
N
V
A
G
D
P
A
H
A
A
D
L
A
R
L
S
R
Q
M
L
R
H
R
M
R
N
M
D
H
T
L
S
L
C
S
I
T
H
E
G
A
R
T
Q
R
R
Y
D
-------------------------------------
11
PsiBlast_PDB
84.59
25%
-80
- C3 -
4CXK
2
ARS_PSEAE
A:
[3-505]
--
K
R
P
N
F
L
V
I
V
A
D
D
L
G
F
S
D
I
--
G
A
F
G
--
G
E
I
A
T
P
N
L
D
A
L
A
I
A
G
--
L
---
R
L
T
D
F
H
T
T
S
-
A
----
S
P
T
R
S
M
L
L
--
T
G
T
D
H
H
I
A
G
--
L
G
T
V
--------
A
E
A
------
L
T
P
---
E
LEG
K
------------------
P
G
Y
E
G
H
L
NERVVA
L
P
E
L
L
R
-
E
A
G
Y
Q
T
L
M
A
-
G
K
W
H
----------------------
L
G-----------------------
L
-
K
--------------------
P
E
---------
Q
--------
T
PHA
R
G
F
E
------
R
S
F
S
L
----
L
P
G
A
A
N
H
Y
G
F
-----
E
-
P
P
Y
----
D
-
E
S
T
----
P
R
I
L
K
G
T
P
A
L
--
Y
V
-----
E
D
E
R
Y
L
D
T
---------------------
L
P
E
-------
G
F
Y
S
S
D
A
F
G
D
K
L
L
----
Q
Y
L
K
E
---
R
D
Q
S
R
P
F
F
A
Y
L
P
F
S
A
P
H
W
P
L
Q
-
A
P
R
E
I
V
E
K
Y
R
G
R
Y
D
A
--
G
P
E
A
L
R
Q
E
R
--
L
A
R
L
K
E
L
GL
V
E
A
D
V
----------
E
A
H
P
V
L
A
L
T
R
--
E
W
E
A
L
------------
E
D
E
E
R
A
K
--------
S
A
R
A
M
E
-----
V
Y
A
A
M
V
E
R
M
D
W
N
I
G
R
V
V
D
Y
L
R
R
Q
G
E
L
D
N
T
F
V
L
F
M
S
D
N
G
AEGALLEAFPKFGP
D
-
L
L
D
F
L
D
R
H
YDNSLENIGS
A
N
S
-
Y
----------------------------------------------------------------------------
V
-----
W
-------------
Y
-
G
P
--------------
R
--
W
--------
A
Q
--
A
A
T
APSRLYKAFTTQGGI
R
V
P
A
L
V
R
Y
P
R
---
L
--
S
-
R
Q
G
A
I
S
----
H
-
A
-
F
--
A
T
V
M
D
V
T
P
T
L
L
D
L
A
G
V
R
HPGKRWRG
R
E
I
A
E
P
R
------
G
R
S
W
L
G
W
L
---------
S
G
--
E
-------------
T
---
E
---
A
A
H
D
-
E
----
N
---
T
-
V
--
T
--
G
W
G
-----------
L
F
G
M
R
---------------
A
I
R
Q
G
D
W
K
A
V
-
Y
L
P
--
A
P
V
G
-
P
-
A
T
W
Q
L
Y
D
L
A
R
D
P
G
E
I
H
D
L
A
D
S
Q
P
G
K
L
A
E
L
I
E
H
W
K
R
Y
V
S
D
T
G
V
V
----------------------------------------------------------
19
PsiBlast_PDB
84.55
25%
-82
- C3 -
4CYS
6
ARS_PSEAE
A:
[3-505]
--
K
R
P
N
F
L
V
I
V
A
D
D
L
G
F
S
D
I
--
G
A
F
G
--
G
E
I
A
T
P
N
L
D
A
L
A
I
A
G
--
L
---
R
L
T
D
F
H
T
A
S
-
A
----
S
P
T
R
S
M
L
L
--
T
G
T
D
H
H
I
A
G
--
I
G
T
V
--------
A
E
A
------
L
T
P
---
E
LEG
K
------------------
P
G
Y
E
G
H
L
NERVVA
L
P
E
L
L
R
-
E
A
G
Y
Q
T
L
M
A
-
G
K
W
H
----------------------
L
G-----------------------
L
-
K
--------------------
P
E
---------
Q
--------
T
PHA
R
G
F
E
------
R
S
F
S
L
----
L
P
G
A
A
N
H
Y
G
F
-----
E
-
P
P
Y
----
D
-
E
S
T
----
P
R
I
L
K
G
T
P
A
L
--
Y
V
-----
E
D
E
R
Y
L
D
T
---------------------
L
P
E
-------
G
F
Y
S
S
D
A
F
G
D
K
L
L
----
Q
Y
L
K
E
---
R
D
Q
S
R
P
F
F
A
Y
L
P
F
S
A
P
H
W
P
L
Q
-
A
P
R
E
I
V
E
K
Y
R
G
R
Y
D
A
--
G
P
E
A
L
R
Q
E
R
--
L
A
R
L
K
E
L
GL
V
E
A
D
V
----------
E
A
H
P
V
L
A
L
T
R
--
E
W
E
A
L
------------
E
D
E
E
R
A
K
--------
S
A
R
A
M
E
-----
V
Y
A
A
M
V
E
R
M
D
W
N
I
G
R
V
V
D
Y
L
R
R
Q
G
E
L
D
N
T
F
V
L
F
M
S
D
N
G
AEGALLEAFPKFGP
D
-
L
L
D
F
L
D
R
H
YDNSLENIGS
A
N
S
-
Y
----------------------------------------------------------------------------
V
-----
W
-------------
Y
-
G
P
--------------
R
--
W
--------
A
Q
--
A
A
T
APSRLYKAFTTQGGI
R
V
P
A
L
V
R
Y
P
R
---
L
--
S
-
R
Q
G
A
I
S
----
H
-
A
-
F
--
A
T
V
M
D
V
T
P
T
L
L
D
L
A
G
V
R
HPGKRWRG
R
E
I
A
E
P
R
------
G
R
S
W
L
G
W
L
---------
S
G
--
E
-------------
T
---
E
---
A
A
H
D
-
E
----
N
---
T
-
V
--
T
--
G
W
G
-----------
L
F
G
M
R
---------------
A
I
R
Q
G
D
W
K
A
V
-
Y
L
P
--
A
P
V
G
-
P
-
A
T
W
Q
L
Y
D
L
A
R
D
P
G
E
I
H
D
L
A
D
S
Q
P
G
K
L
A
E
L
I
E
H
W
K
R
Y
V
S
D
T
G
V
V
E
G
A
S
P
F
L
V
R
-------------------------------------------------
21
HHSearch
84.34
25%
-82
- C3 -
3ED4
6
?
A:
[27-477]
---
Q
P
N
L
V
I
I
M
A
D
D
L
G
Y
G
D
L
--
A
T
Y
G
-
H
Q
I
V
K
T
P
N
I
D
R
L
A
Q
E
G
--
V
---
K
F
T
D
Y
Y
A
P
A
-
P
--
L
S
S
P
S
R
A
G
L
L
--
T
G
R
M
P
F
R
T
G
--
I
R
S
W
--------
I
P
S
GKDVA-
L
G
R
---
N
---
E
------------------
L
T
I
A
N
L
L
-----------
K
-
A
Q
G
Y
D
T
A
M
M
-
G
K
L
H
----------------------
L
------------------------
N
-
A
--------------------
G
G
---------
D
RTDQPQAQ
D
---
M
G
F
D
------
Y
S
L
A
N
----
T
A
G
F
V
T
-
D
A
T
-----
L
-
D
N
A
----
K
E
R
P
R
Y
G
M
V
Y
P
-----
T
G
W
--
L
------------
R
N
---------------------
G
Q
P
-------
T
P
R
A
D
K
M
S
G
E
Y
V
S
S
E
V
V
N
W
L
D
N
K
K
---
D
S
K
P
F
F
L
Y
V
A
F
T
E
V
H
S
P
L
A
-
S
P
K
K
Y
L
D
M
Y
S
Q
Y
M
S
A
--
Y
Q
----
K
Q
--------------
H
P
D
----------
L
------------
F
Y
G
D
------------
W
A
D
K
P
-
W
--------
R
G
V
--
G
-----
E
Y
Y
A
N
I
S
Y
L
D
A
Q
V
G
K
V
L
D
K
I
K
A
M
G
E
E
D
N
T
I
V
I
F
T
S
D
N
G
--------------
P
-
V
T
REARKVYELN
L
A
----
G
E
T
D
G
----------------------------------------------------------------------------
L
-----
R
-------------
G
R
K
D
--------------
N
--
L
--------
W
E
--
G
G
I
---------------
R
V
P
A
I
I
K
Y
G
K
---
H
L-
P
-
Q
G
M
V
S
D
----
T
-
P
-
V
--
Y
G
L
-
D
W
M
P
T
L
A
K
M
M
N
F
K
-----------
L
P
T
D
R
T
F
D
--
G
E
S
L
V
P
V
L
---
E
---
Q
K
A
L
K
R
E
K------------
P
---
L
---
I
F
-
G
-
I
----
D
---
M
P
F
--
Q
--
D
-
D
-----------
P
T
D
E
W
---------------
A
I
R
D
G
D
W
K
M
I
-
I
----
D
R
N
N
K
P
-
K
Y
--
L
Y
N
L
K
S
D
R
Y
E
T
L
N
L
I
G
K
K
--
P
D
I
E
K
Q
M
Y
G
K
F
L
K
Y
K
T
D
I
D
N
D
S
L
M
K
A
R
G
D
K
P
E
A
V
T
W
G
----------------------------------------
16
PsiBlast_PDB
83.91
25%
-80
- C3 -
4CYR
10
ARS_PSEAE
A:
[3-505]
--
K
R
P
N
F
L
V
I
V
A
D
D
L
G
--
F
S
--
D
I
G
T
F
G
G
E
I
A
T
P
N
L
D
A
L
A
I
A
G
--
L
---
R
L
T
D
F
H
T
A
S
-
A
----
S
P
T
R
S
M
L
L
--
T
G
T
D
H
H
I
A
G
--
I
G
T
M
--------
A
E
A
------
L
T
P
---
E
LEG
K
------------------
P
G
Y
E
G
H
L
NERVVA
L
P
E
L
L
R
-
E
A
G
Y
Q
T
L
M
A
-
G
K
W
H
----------------------
L
G-----------------------
L
-
K
--------------------
P
E
---------
Q
--------
T
PHA
R
G
F
E
------
R
S
F
A
L
----
L
P
G
A
A
N
H
Y
G
F
-----
E
-
P
P
Y
----
D
-
E
S
T
----
P
R
I
L
K
G
T
P
A
L
--
Y
V
-----
E
D
E
R
Y
L
D
T
---------------------
L
P
E
-------
G
F
Y
S
S
D
A
F
G
D
K
L
L
----
Q
Y
L
K
E
---
R
D
Q
S
R
P
F
F
A
Y
L
P
F
S
A
P
H
W
P
L
Q
-
A
P
R
E
I
V
E
K
Y
R
G
R
Y
D
A
--
G
P
E
A
L
R
Q
E
R
--
L
A
R
L
K
E
L
GL
V
E
A
D
V
----------
E
A
H
P
V
L
A
L
T
R
--
E
W
E
A
L
------------
E
D
E
E
R
A
K
--------
S
A
R
A
M
E
-----
V
Y
A
A
M
V
E
R
M
D
W
N
I
G
R
V
V
D
Y
L
R
R
Q
G
E
L
D
N
T
F
V
L
F
M
S
D
N
G
AEGALLEAFPKFGP
D
-
L
L
D
F
L
D
R
H
YDNSLENIGR
A
N
S
-
Y
----------------------------------------------------------------------------
V
-----
W
-------------
Y
-
G
P
--------------
R
--
W
--------
A
Q
--
A
A
T
APSRLYKAFTTQGGI
R
V
P
A
L
V
R
Y
P
R
---
L
--
S
-
R
Q
G
A
I
S
----
H
-
A
-
F
--
A
T
V
M
D
V
T
P
T
L
L
D
L
A
G
V
R
HPGKRWRG
R
E
I
A
E
P
R
------
G
R
S
W
L
G
W
L
---------
S
G
--
E
-------------
T
---
E
---
A
A
H
D
-
E
----
N
---
T
-
V
--
T
--
G
W
G
-----------
L
F
G
M
R
---------------
A
I
R
Q
G
D
W
K
A
V
-
Y
L
P
--
A
P
V
G
-
P
-
A
T
W
Q
L
Y
D
L
A
R
D
P
G
E
I
H
D
L
A
D
S
Q
P
G
K
L
A
E
L
I
E
H
W
K
R
Y
V
S
D
T
G
V
V
E
---------------------------------------------------------
5
PsiBlast_PDB
83.86
24%
-91
- C3 -
4UPH
2
?
A:
[45-502]
----
P
N
V
L
L
I
S
A
D
Q
W
R
G
D
C
L
--
S
A
V
G
H
A
S
V
-
K
T
P
N
V
D
A
L
A
Q
D
G
--
V
---
L
F
T
R
H
F
A
G
T
-
A
--
P
-
S
P
A
R
A
T
L
Y
--
T
G
L
Y
Q
M
N
H
R
--
V
C
R
N
--------
G
S
P
------
L
D
A
---
R
---
F
------------------
D
N
L
A
L
A
A
-----------
R
-
R
G
G
Y
D
P
T
L
F
-
G
Y
T
D
-----------------------------------------------
T
-
A
--------------------
P
D
PRGMDPND
P
H
--------
L
---
T
T
Y
E
------
G
V
L
P
G
FSAR
Q
L
L
P
E
H
-
E
K
Q
-----
W
-
L
S
W
L
R
S
R
G
-
H
P
E
----
A
T
-----
S
R
D
--
I
H
IPVGA
T
P
G
E
I
S
D
V
---------------------
A
P
A
-------
Y
S
K
D
E
T
----
Q
T
A
F
L
A
G
E
F
I
R
W
L
G
E
Q
D
A
--
P
W
F
A
H
V
S
F
L
R
P
H
P
P
F
S
-
V
P
E
P
Y
N
R
M
F
T
P
S
D
G
P
--
A
F
----
A
R
A
--
A
N
R
------
E
A
E
Q
A
----------
V
H
P
L
L
A
F
A
L
P
--
L
I
G
K
D
SFIYGGEGSASD
W
T
S
E
D
L
S
--------
A
I
R
--
A
-----
I
Y
Y
G
M
I
A
E
V
D
T
Q
L
G
R
I
W
Q
A
L
K
N
V
G
A
W
D
D
T
L
I
I
F
T
S
D
H
A
--------------
E
-
M
M
----------------
G
D
H
-
W
----------------------------------------------------------------------------
M
-----
L
-------------
G
-
K
G
--------------
G
--
F
--------
F
D
--
G
S
Y
---------------
H
V
P
L
V
I
R
D
P
G
---
H
PG
G
-
A
G
R
Q
V
E
----
R
-
F
-
T
--
S
A
A
-
D
I
F
P
T
L
C
D
R
L
G
-------------
L
V
P
D
N
H
L
D
--
G
G
T
L
V
P
F
L
---
E
---
G
G
E
P
--
E
GWRD
A
A
F
W
E
F
D
FR
D
---
I
---
A
K
-
G
-
E
A
E
R
H
F
---
G
-
L
--
K
--
S
-
N
-----------
A
C
N
L
A
---------------
V
I
R
D
E
R
F
K
Y
V
-
H
----
F
A
G
L
-
P
-
P
L
--
L
Y
D
L
A
K
D
P
M
E
L
T
N
V
A
A
D
A
D
Y
A
A
V
R
L
G
Y
A
E
K
L
L
S
L
R
A
Q
H
L
D
Q
T
L
A
Y
T
E
L
T
E
K
G
P
V
S
R
R
P
---------------------------------------
23
HHSearch
83.53
25%
-84
- C3 -
3B5Q
15
?
A:
[15-448]
--
E
K
P
N
F
L
I
I
Q
C
D
H
L
T
Q
R
V
V
--
G
A
Y
G
-
Q
T
Q
G
C
T
L
P
I
D
E
V
A
S
R
G
--
V
---
I
F
S
N
A
Y
V
G
C
-
P
--
L
S
Q
P
S
R
A
A
L
W
--
S
G
M
M
P
H
Q
T
N
--
V
R
S
N
--------
S
S
E
PVNTR-
L
P
E
---
N
---
V
------------------
P
T
L
G
S
L
F
-----------
S
-
E
S
G
Y
E
A
V
H
F
-
G
K
T
H
----------------------
D
------------------------
M
-
G
--------------------
S
-------------------
L
---
R
G
F
K
------
H
K
E
P
V
----
A
K
P
----
F
----------------
T
-
D
P
-------------
E
-----------------------------------------
F
-------
P
V
N
N
D
S
F
L
D
V
G
T
C
E
D
A
V
A
Y
L
S
N
P
----
P
K
E
P
F
I
C
I
A
D
F
Q
N
P
H
N
I
C
G
-
F
I
G
E
N
A
G
V
H
T
D
R
P
I
S
GP
L
P
----
E
L
P
DN
F
D
V
EDW---
S
N
I
P
T
----------
P
V
Q
Y
I
C
C
S
H
R
R
M
T
Q
A
A
H
------------
W
N
E
E
N
Y
R
--------
H
Y
I
--
A
-----
A
F
Q
H
Y
T
K
M
V
S
K
Q
V
D
S
V
L
K
A
L
Y
S
T
P
A
G
R
N
T
I
V
V
I
M
A
D
H
G
--------------
D
-
G
M
----------------
A
S
H
-
R
----------------------------------------------------------------------------
M
-----
V
-------------
T
-
K
H
I-------------
S
--
F
--------
Y
D
--
E
M
T
---------------
N
V
P
F
I
F
A
G
P
G
---
I
--
K
Q
Q
K
K
P
V
D
----
H
-
L
-
L
T
Q
P
T
L
-
D
L
L
P
T
L
C
D
L
A
G
I
A
-----------
V
P
A
--
E
K
A
--
G
I
S
L
A
P
T
L
---
R
---
G
E
K
Q
KK
S
H------------
P
---
Y
---
V
V
-
S
-
E
----
W
---
H
-
S
--
E
YE
Y
-
V
-----------
T
T
P
G
R
---------------
M
V
R
G
P
R
Y
K
Y
T
-
H
----
Y
L
E
G
N
G
-
E
E
--
L
Y
D
M
K
K
D
P
G
E
R
K
N
L
A
K
D
P
K
Y
S
K
I
L
A
E
H
R
A
L
L
D
D
Y
I
T
R
S
K
D
D
Y
R
S
L
K
V
D
A
D
P
R
C
R
N
H
T
P
G
Y
P
S
H
E
G
P
G
A
R
E
I
--------------------------
3
PsiBlast_PDB
83.48
25%
-89
- C3 -
3ED4
6
?
A:
[28-453]
----
P
N
L
V
I
I
M
A
D
D
L
G
Y
G
D
L
--
A
T
Y
G
-
H
Q
I
V
K
T
P
N
I
D
R
L
A
Q
E
G
--
V
---
K
F
T
D
Y
Y
A
P
A
-
P
--
L
S
S
P
S
R
A
G
L
L
--
T
G
R
M
P
F
R
T
G
IR
S
W
I
P
--------
S
G
K
------
D
V
A
LGR
N
---
E
------------------
L
T
I
A
N
L
L
-----------
K
-
A
Q
G
Y
D
T
A
M
M
-
G
K
L
H
----------------------
L
N-----------------------
A
-
G
--------------------
G
D
RTDQPQA--
Q
--------
D
---
M
G
F
D
------
Y
S
L
A
N
-------
T
A
G
-
F
V
T
-----
D
-
A
T
L
----
D
-
N
A
K
----
E
R
-----
P
R
Y
G
M
V
Y
-----
P
T
G
W
L
R
N
G
---------------------
Q
P
T
-------
P
R
A
D
K
M
S
-
G
E
Y
V
S
S
E
V
V
N
W
L
D
N
---
K
K
D
S
K
P
F
F
L
Y
V
A
F
T
E
V
H
S
P
L
A
-
S
P
K
K
Y
L
D
M
Y
S
-------------
Q
Y
M
--
S
A
Y
------
Q
K
Q
H
P
----------
D
----
L
F
Y
G
D
--
W
A
D
K
P
------------
W
--------------
R
G
V
--
G
-----
E
Y
Y
A
N
I
S
Y
L
D
A
Q
V
G
K
V
L
D
K
I
K
A
M
G
E
E
D
N
T
I
V
I
F
T
S
D
N
G
--------------
P
-
V
T
----------------
R
E
A
-
R
----------------------------------------------------------------------------
K
-----
V
-------------
Y
-
E
L
N
L
A
G
E
TDGLRGRKD
N
--
L
--------
W
E
--
G
G
I
---------------
R
V
P
A
I
I
K
Y
G
K
---
H
--
L
-
P
Q
G
M
V
S
----
D
-
T
P
V
--
Y
G
L
-
D
W
M
P
T
L
A
K
M
M
N
F
K
-----------
L
P
T
D
R
T
F
D
--
G
E
S
L
V
P
V
L
---
E
---
Q
K
A
L
--
K
-------------
R
---
E
K
P
L
I
F
-
G
I
D
----
M
---
P
-
F
--
Q
--
D
-
D
-----------
P
T
D
E
W
---------------
A
I
R
D
G
D
W
K
M
I
-
I
----
D
R
N
N
K
P
-
K
Y
--
L
Y
N
L
K
S
D
R
Y
E
T
L
N
L
I
G
K
K
P
D
I
E
K
Q
M
Y
G
K
F
L
K
Y
K
T
D
I
D
N
D
S
L
M
K
A
R
G
D
K
P
E
A
V
T
W
G
------------------------------------------
17
PsiBlast_PDB
82.89
25%
-80
- C3 -
4CXS
4
?
A:
[3-505]
--
K
R
P
N
F
L
V
I
V
A
D
D
L
G
--
F
S
--
D
I
G
T
F
G
G
E
I
A
T
P
N
L
D
A
L
A
I
A
G
--
L
---
R
L
T
D
F
H
T
A
S
-
A
----
S
P
T
R
S
M
L
L
--
T
G
T
D
H
H
I
A
G
--
I
G
T
M
--------
A
E
A
------
L
------LEG
K
------------------
P
G
Y
E
G
H
L
NERVVA
L
P
E
L
L
R
-
E
A
G
Y
Q
T
L
M
A
-
G
K
W
H
----------------------
L
G-----------------------
L
-
K
--------------------
P
E
---------
Q
--------
T
PHA
R
G
F
E
------
R
S
F
A
L
----
L
P
G
A
A
N
H
Y
G
F
-----
E
-
P
P
Y
----
D
-
E
S
T
----
P
R
I
L
K
G
T
P
A
L
--
Y
V
-----
E
D
E
R
Y
L
D
T
---------------------
L
P
E
-------
G
F
Y
S
S
D
A
F
G
D
K
L
L
----
Q
Y
L
K
E
---
R
D
Q
S
R
P
F
F
A
Y
L
P
F
S
A
P
H
W
P
L
Q
-
A
P
R
E
I
V
E
K
Y
R
G
R
Y
D
A
--
G
P
E
A
L
R
Q
E
R
--
L
A
R
L
K
E
L
GL
V
E
A
D
V
----------
E
A
H
P
V
L
A
L
T
R
--
E
W
E
A
L
------------
E
D
E
E
R
A
K
--------
S
A
R
A
M
E
-----
V
Y
A
A
M
V
E
R
M
D
W
N
I
G
R
V
V
D
Y
L
R
R
Q
G
E
L
D
N
T
F
V
L
F
M
S
D
N
G
AEGALLEAFPKFGP
D
-
L
L
D
F
L
D
R
H
YDNSLENIGR
A
N
S
-
Y
----------------------------------------------------------------------------
V
-----
W
-------------
Y
-
G
P
--------------
R
--
W
--------
A
Q
--
A
A
T
APSRLYKAFTTQGGI
R
V
P
A
L
V
R
Y
P
R
---
L
--
S
-
R
Q
G
A
I
S
----
H
-
A
-
F
--
A
T
V
M
D
V
T
P
T
L
L
D
L
A
G
V
R
HPGKRWRG
R
E
I
A
E
P
R
------
G
R
S
W
L
G
W
L
---------
S
G
--
E
-------------
T
---
E
---
A
A
H
D
-
E
----
N
---
T
-
V
--
T
--
G
W
G
-----------
L
F
G
M
R
---------------
A
I
R
Q
G
D
W
K
A
V
-
Y
L
P
--
A
P
V
G
-
P
-
A
T
W
Q
L
Y
D
L
A
R
D
P
G
E
I
H
D
L
A
D
S
Q
P
G
K
L
A
E
L
I
E
H
W
K
R
Y
V
S
D
T
G
V
V
----------------------------------------------------------
15
PsiBlast_PDB
82.58
25%
-82
- C3 -
4CXU
2
?
A:
[3-505]
--
K
R
P
N
F
L
V
I
V
A
D
D
L
G
--
F
S
--
D
I
G
T
F
G
G
E
I
A
T
P
N
L
D
A
L
A
I
A
G
--
L
---
R
L
T
D
F
H
T
A
S
-
A
----
S
P
T
R
S
M
L
L
--
T
G
T
D
H
H
I
A
G
--
I
G
T
M
--------
A
E
A
------
L
-----------------------------
G
Y
E
G
H
L
NERVVA
L
P
E
L
L
R
-
E
A
G
Y
Q
T
L
M
A
-
G
K
W
H
----------------------
L
G-----------------------
L
-
K
--------------------
P
E
---------
Q
--------
T
PHA
R
G
F
E
------
R
S
F
A
L
----
L
P
G
A
A
N
H
Y
G
F
-----
E
-
P
P
Y
----
D
-
E
S
T
----
P
R
I
L
K
G
T
P
A
L
--
Y
V
-----
E
D
E
R
Y
L
D
T
---------------------
L
P
E
-------
G
F
Y
S
S
D
A
F
G
D
K
L
L
----
Q
Y
L
K
E
---
R
D
Q
S
R
P
F
F
A
Y
L
P
F
S
A
P
H
W
P
L
Q
-
A
P
R
E
I
V
E
K
Y
R
G
R
Y
D
A
--
G
P
E
A
L
R
Q
E
R
--
L
A
R
L
K
E
L
GL
V
E
A
D
V
----------
E
A
H
P
V
L
A
L
T
R
--
E
W
E
A
L
------------
E
D
E
E
R
A
K
--------
S
A
R
A
M
E
-----
V
Y
A
A
M
V
E
R
M
D
W
N
I
G
R
V
V
D
Y
L
R
R
Q
G
E
L
D
N
T
F
V
L
F
M
S
D
N
G
AEGALLEAFPKFGP
D
-
L
L
D
F
L
D
R
H
YDNSLENIGR
A
N
S
-
Y
----------------------------------------------------------------------------
V
-----
W
-------------
Y
-
G
P
--------------
R
--
W
--------
A
Q
--
A
A
T
APSRLYKAFTTQGGI
R
V
P
A
L
V
R
Y
P
R
---
L
--
S
-
R
Q
G
A
I
S
----
H
-
A
-
F
--
A
T
V
M
D
V
T
P
T
L
L
D
L
A
G
V
R
HPGKRWRG
R
E
I
A
E
P
R
------
G
R
S
W
L
G
W
L
---------
S
G
--
E
-------------
T
---
E
---
A
A
H
D
-
E
----
N
---
T
-
V
--
T
--
G
W
G
-----------
L
F
G
M
R
---------------
A
I
R
Q
G
D
W
K
A
V
-
Y
L
P
--
A
P
V
G
-
P
-
A
T
W
Q
L
Y
D
L
A
R
D
P
G
E
I
H
D
L
A
D
S
Q
P
G
K
L
A
E
L
I
E
H
W
K
R
Y
V
S
D
T
G
V
V
----------------------------------------------------------
47
Fugue
79.22
22%
-73
- C3 -
1E3C
2
ARSA_HUMAN
P:
[1-485]
--
R
P
P
N
I
V
L
I
F
A
D
D
L
G
Y
G
D
L
--
G
C
Y
G
H
P
S
S
-
T
T
P
N
L
D
Q
L
A
A
G
G
--
L
---
R
F
T
D
F
Y
V
P
V
-
S
--
L
S
T
P
S
R
A
A
L
L
--
T
G
R
L
P
V
R
M
G
--
M
Y
P
G
--------
V
L
V
PSSRGG
L
P
L
---
E
---
E
------------------
V
T
V
A
E
V
L
-----------
A
-
A
R
G
Y
L
T
G
M
A
-
G
K
W
H
----------------------
L
GVGPEGAFLPPH------------
Q
-
G
--------------------
F
H
---------
R
--------
F
---
L
G
I
P
YSHDQG
P
C
Q
N
L
----
T
C
F
P
P
A
-
T
P
C
-----
D
-
G
G
C
----
D
-
Q
G
L
----
V
P
-----
I
P
L
--
L
A
-----
N
L
S
V
E
A
Q
---------------------------------
P
P
W
L
P
G
L
E
A
R
Y
M
A
F
A
H
D
L
M
A
D
A
Q
R
E
--
D
R
P
F
F
L
Y
Y
A
S
H
H
T
H
Y
P
Q
F
-
S
G
Q
S
F
A
E
--------------------------------------------------------------------------------
R
--------
S
G
R
--
G
-----
P
F
G
D
S
L
M
E
L
D
A
A
V
G
T
L
M
T
A
I
G
D
L
G
L
L
E
E
T
L
V
I
F
T
A
D
N
G
--------------
P
-
E
T
----------------
M
R
M
-
S
----------------------------------------------------------------------------
R
-----
G
GCSGLLRC-----
G
-
K
G
--------------
T
--
T
--------
Y
E
--
G
G
V
---------------
R
E
P
A
L
A
F
W
P
G
---
H
--
I
-
A
P
G
V
T
H
----
E
-
L
-
A
--
S
S
L
-
D
L
L
P
T
L
A
A
L
A
G
A
P
-----------
L
-
P
N
V
T
L
D
--
G
F
D
L
S
P
L
L
---
L
---
G
T
G
K
SP
R
-------------
Q
---
S
---
L
F
-
F
-
Y
----
P
---
S
-
Y
--
P
--
D
-
E
-----------
V
R
G
V
F
---------------
A
V
R
T
G
K
Y
K
A
H
-
F
----
F
T
Q
G
-
S
------
A
H
S
D
T
T
A
D
P
A
C
H
A
S
S
S
L
T
A
H
E
P
P
L
L
Y
D
L
S
K
D
P
G
E
N
Y
N
L
L
G
A
T
P
E
V
L
Q
A
L
K
Q
L
Q
L
L
K
A
Q
L
D
A
A
V
T
F
G
P
S
Q
V
A
R
G
E
D
P
A
L
Q
I
C
C
H
P
G
C
T
P
R
P
A
C
C
H
C
P
6
PsiBlast_PDB
78.38
25%
-70
- C3 -
3B5Q
15
?
A:
[15-427]
--
E
K
P
N
F
L
I
I
Q
C
D
H
L
T
Q
R
V
V
--
G
A
Y
G
Q
T
Q
G
C
T
L
P
-
I
D
E
V
A
S
R
G
--
V
---
I
F
S
N
A
Y
V
G
C
-
P
--
L
S
Q
P
S
R
A
A
L
W
--
S
G
M
M
P
H
Q
T
N
--
V
R
S
N
--------
S
S
E
PVNTR-
L
P
E
---
N
---
V
------------------
P
T
L
G
S
L
F
-----------
S
-
E
S
G
Y
E
A
V
H
F
-
G
K
T
H
----------------------
D
------------------------
M
-
G
-------------------------------
S
--------
L
---
R
G
F
K
------
H
K
E
P
------------------------
V
----
A
-
K
P
F
----
T
D
-----
P
E
F
--
P
V
-----
N
N
D
S
F
L
D
V
---------------------
G
T
C
E
D
A
V
A
Y
L
S
N
P
P
K
E
P
F
I
C
I
A
D
F
Q
N
P
H
N
I
C
G
F
I
G
E
N
A
G
V
H
T
D
R
P
I
S
G
P
L
P
E
L
P
D
N
-
F
D
V
E
D
W
S
-----
N
I
P
--
T
P
----
V
Q
Y
--
I
C
C
----------------------
S
H
R
R
M
T
Q
A
A
--
H
W
N
----------------
E
E
N
Y
R
--------
H
Y
I
--
A
-----
A
F
Q
H
Y
T
K
M
V
S
K
Q
V
D
S
V
L
K
A
L
Y
S
T
P
A
G
R
N
T
I
V
V
I
M
A
D
H
G
--------------
D
G
M
A
----------------
S
H
R
-
M
----------------------------------------------------------------------------
V
-----
T
-------------
K
-
H
I
--------------
S
--
F
--------
Y
D
--
E
M
T
---------------
N
V
P
F
I
F
A
G
P
G
I
K
Q
Q
--
K
-
K
P
V
D
H
L
----
L
-
T
-
Q
--
P
T
L
-
D
L
L
P
T
L
C
D
L
A
G
I
A
-----------
V
----
P
A
E
KA
G
I
S
L
A
P
T
L
---
R
GEK
Q
K
K
S
--
H
-------------
P
---
Y
---
V
V
-
S
-
E
----
W
---
H
-
S
EY
E
--
Y
-
V
-----------
T
T
P
G
R
---------------
M
V
R
G
P
R
Y
K
Y
T
H
Y
----
L
E
G
N
-
G
-
E
E
--
L
Y
D
M
K
K
D
P
G
E
R
K
N
L
A
K
D
P
K
Y
S
K
I
L
A
E
H
R
A
L
L
D
D
Y
I
T
R
S
K
D
D
Y
R
S
L
K
V
D
A
D
P
R
C
R
N
H
T
P
G
Y
P
S
H
E
G
P
G
A
R
E
I
--------------------------
29
HHSearch
68.77
18%
-90
- C3 -
3LXQ
1
?
A:
[83-413]
-
G
K
R
K
N
L
V
I
L
L
Q
E
S
L
G
A
Q
F
V
--
G
S
L
G
-
G
-
L
P
L
T
P
N
L
D
E
L
M
Q
E
G
--
W
---
Q
F
T
Q
M
Y
A
T
G
-
T
--
R
S
V
R
G
I
E
A
V
T
--
T
G
F
P
P
S
P
S
R
--
A
V
V
K
--------
L
S
K
------
S
Q
T
---
G
---
F
------------------
F
T
I
A
D
L
L
-----------
K
-
E
Q
G
Y
H
T
Q
F
I
-
Y
G
G
E
----------------------
A
------------------------
N
-
F
--------------------
D
N
---------
M
K
T
F
F
F
---
G
---
N
G
F
D
------
Q
I
V
E
E
----
K
N
Y
T
N
P
-----------------------------------------------------------------------------
G
-------
F
V
G
S
W
G
V
S
D
E
D
L
Y
N
K
A
D
E
E
F
E
R
L
S
K
--
G
D
K
P
F
F
S
L
V
F
T
S
S
N
H
S
P
Y
E
-
Y
P
E
G
K
I
E
Q
Y
D
--------------------------------------------------------------------------------------
S
E
H
--
M
-----
T
R
N
N
A
V
K
Y
S
D
Y
A
L
G
T
F
F
D
K
A
K
K
S
S
Y
W
D
D
T
I
F
I
V
I
A
D
H
D
--------------
A
-
R
V
----------------
F
G
A
-----------------------------------------------------------------------------------------------------
N
--------------
L
--
V
--------
P
V
--
K
H
F
---------------
H
I
P
A
L
I
I
G
K
D
---
I
--
Q
--
P
R
K
D
D
----
R
-
I
-
A
--
N
N
I
-
D
M
P
P
T
L
L
S
L
I
G
V
D
-----------
A
K
T
--
P
M
I
--
G
R
D
L
T
K
P
L
---
A
---
R
E
D
---
E
-------------
R
---
A
---
M
M
----------------------
Q
-----------
Y
D
K
N
F
---------------
G
Y
L
T
R
D
N
L
V
V
-
L
----
S
P
G
E
-
K
-
V
S
--
T
M
E
Y
D
F
E
S
Q
T
M
K
P
L
E
V
D
E
S
V
I
D
R
A
K
A
N
A
L
F
A
S
K
A
Y
Q
N
N
W
Y
S
S
K
R
-----------------------------------------------------
38
HHSearch
66.23
22%
-101
* C3 *
2GSO
3
?
A:
[5-376]
--
T
P
H
A
L
L
L
I
S
I
D
G
L
R
A
D
M
L
--
D
R
------
G
I
T
P
N
L
S
H
L
A
R
E
G
--
V
---
R
A
R
W
M
A
P
S
Y
P
S
--
L
T
F
P
N
H
Y
T
L
V
--
T
G
L
R
P
D
H
H
G
--
I
V
H
N
--------
S
M
R
------
D
P
T
---
L
---
G
GFWLSK
S
E
A
V
G
DARWWGG
E
P
V
W
V
G
V
-----------
E
-
N
T
G
Q
H
A
A
T
W
-
S
-------------------------
W
------------------------
P
-
G
--------------------
S
-------------------
E
---
A
A
I
K
------
G
V
---------
R
P
S
------------------------------------
Q
-----------------------------------------
W
-------
R
H
Y
Q
K
G
V
R
L
D
T
R
V
D
A
V
R
G
W
L
A
T
D
G
---
A
Q
R
N
R
L
V
T
L
Y
F
E
H
V
D
E
A
G
H
-
D
-------
H
------------------------------------------------------------------------------
G
--------
P
E
S
--
R
-----
Q
Y
A
D
A
V
R
A
V
D
A
A
I
G
R
L
L
A
G
M
Q
R
D
G
T
R
A
R
T
N
I
I
V
V
S
D
H
G
--------------
M
-
A
E
----------------
V
A
P
-
G
HAISVEDIAPPQIATAITDGQV
I
G
F
E
P
L
PGQ
Q
A
A
A
E
A
S
V
LGAHDH
Y
D
C
W
RKAELPARWQYGSHPRIPS
L
V
C
Q
M
H
EG
W
D
A
L
--
F
P
D
K
L
A
K
RAQ
R
G
T
R
G
-
S
H
--------------
G
YD
P
--------
A
L
--
P
S
M
---------------
R
A
V
F
L
A
Q
G
P
D
---
L
--
A
-
Q
G
K
-
T
L
----
P
-
G
-
F
--
D
N
V
-
D
V
Y
A
L
M
S
R
L
L
G
I
P
-----------
A
A
P
---
N
D
--
G
N
P
A
T
L
L
P
---
A
---
L
R
M
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
31
HHSearch
63.72
19%
-89
- C3 -
2W8D
3
LTAS2_BACSU
A:
[29-339]
-
A
E
G
K
N
V
I
Y
V
S
L
E
S
L
Q
S
F
I
I
--
D
Y
K
I
-
D
G
K
E
V
T
P
F
L
N
K
L
A
H
D
N
E
T
F
---
Y
F
D
N
F
F
H
Q
T
-
G
--
Q
G
K
T
S
D
A
E
F
M
M
E
N
S
L
Y
P
L
A
Q
G
--
S
V
F
V
--------
N
K
A
-------
Q
N
---
T
---
L
------------------
Q
S
V
P
A
I
L
-----------
K
-
S
K
N
Y
T
S
A
T
F
-
H
G
N
T
----------------------
Q
------------------------
T
-
F
--------------------
W
N
---------
R
N
E
M
Y
K
---
A
---
E
G
I
D
------
K
F
F
D
S
----
A
Y
Y
D
M
N
-
E
---------------------------------------------------------------------------
E
-------
N
T
K
N
Y
G
M
K
D
K
P
F
F
K
E
S
M
P
L
L
E
S
-----
L
P
Q
P
F
Y
T
K
F
I
T
L
S
N
H
F
P
F
G
-
M
D
E
G
D
T
D
-
F
-----
P
-------------------------------------------------------------------
A
G
D
F
G
D
--------
S
V
V
--
D
-----
N
Y
F
Q
S
A
H
Y
L
D
Q
S
I
E
Q
F
F
N
D
L
K
K
D
G
L
Y
D
K
S
I
I
V
M
Y
G
D
H
Y
--------------
G
-
I
S
----------------
E
N
H
-
N
K
A
M
A
K
-----------------------------------------------------------------------
V
-----
L
-------------
G
-
K
D
EI------------
T
--
D
--------
Y
D
N
A
Q
L
Q
---------------
R
V
P
L
F
I
H
A
A
G
---
V
--
K
--
G
E
K
V
H
----
K
-
Y
-
A
--
G
D
V
-
D
V
A
P
T
I
L
H
L
L
G
V
D
-----------
T
K
D
-
Y
L
M
S
--
G
S
D
I
L
S
K
E
---
H
---
R
E
V
I
--
P
-------------
F
---
R
---
N
G
-
D
-
F
----
I
---
S
-
P
--
K
--
Y
-
T
-----------
K
I
S
G
K
---------------
Y
Y
D
T
K
T
G
K
E
L
-
D
----
E
S
E
V
-
D
-
K
S
--
E
D
S
L
V
K
K
E
L
E
M
S
D
K
I
I
N
G
D
L
L
R
F
Y
E
P
K
G
F
K
K
V
N
P
S
D
Y
D
Y
T
K
H
-------------------------------------------------------
30
HHSearch
62.67
17%
-81
- C3 -
2W5Q
2
LTAS_STAAW
A:
[27-359]
-
A
K
K
K
N
I
I
K
I
H
L
E
S
F
Q
T
F
L
I
--
N
K
K
V
-
N
G
K
E
V
T
P
F
L
N
K
L
S
S
G
K
--
E
Q
F
T
Y
F
P
N
F
F
H
Q
T
-
G
QG
K
T
S
D
S
E
F
T
M
D
--
N
S
L
Y
G
L
P
Q
G
--
S
A
F
S
--------
L
K
G
-------
D
N
---
T
---
Y
------------------
Q
S
L
P
A
I
L
-----------
D
Q
K
Q
G
Y
K
S
D
V
M
H
G
D
Y
K
----------------------
T
------------------------
F
-
W
--------------------
N
R
D
Q
V
Y
-----
K
--------
H
---
F
G
I
D
------
K
F
Y
D
A
----
T
Y
Y
D
M
S
-
D
---------------------------------------------------------------------------
K
-------
N
V
V
N
L
G
L
K
D
K
I
F
F
K
D
S
A
N
Y
Q
A
K
-----
M
K
S
P
F
Y
S
H
L
I
T
L
T
N
H
Y
P
F
T
-
L
D
E
K
D
A
T
I
E
-------------------------------------------------------------------------
K
S
N
T
G
D
--------
A
T
V
--
D
-----
G
Y
I
Q
T
A
R
Y
L
D
E
A
L
E
E
Y
I
N
D
L
K
K
K
G
L
Y
D
N
S
V
I
M
I
Y
G
D
H
Y
--------------
G
-
I
S
----------------
E
N
H
-
N
----------------------------------------------------------------------------
N
A
M
E
K
L
L
-------------
G
-
E
K
IT
P
-----------
A
--
K
--------
F
T
--
D
L
N
---------------
R
T
G
F
W
I
K
I
P
G
---
K
--
S
--
G
G
I
N
N
----
E
-
Y
-
A
--
G
Q
V
-
D
V
M
P
T
I
L
H
L
A
G
I
D
-----------
T
K
N
-
Y
L
M
F
--
G
T
D
L
F
S
K
G
---
H
---
N
Q
----------------------
V
---
V
P
-----------------------------------
F
R
N
G
---------------
D
F
I
T
K
D
Y
K
Y
V
-
N
----
G
K
I
Y
-
S
-
N
K
--
N
N
E
L
I
T
T
Q
P
A
D
F
E
K
N
K
K
Q
V
E
K
D
L
E
M
S
D
N
V
L
N
G
D
L
F
R
F
Y
K
N
P
D
F
K
K
V
N
P
S
K
Y
K
Y
E
T
G
P
K
---------------------------------------
49
Fugue
60.69
14%
-49
- C3 -
2W5Q
2
LTAS_STAAW
A:
[1-424]
----------
S
E
D
D
L
T
K
V
L
N
--
Y
T
K
Q
R
Q
T
E
P
N
P
E
Y
Y
G
V
A
K
K
K
N
--
I
---
I
K
I
H
L
E
S
F
Q
-
T
--
F
L
I
N
K
K
V
-----
N
G
K
E
V
T
-------
P
F
--------
L
N
K
------
L
S
S
---
G
---
K
------------------
E
Q
F
-
T
Y
F
-----------
P
-
N
F
F
H
Q
T
---------------------------------------------------------
G
--------------------
Q
G
---------
K
--------
T
---
S
D
S
E
------
F
T
M
D
N
----
S
L
Y
G
L
P
-
Q
G
S
-----
A
-
F
S
L
----
K
-
G
D
N
----
T
-----------
Y
Q
-----
S
L
P
A
I
L
D
Q
---------------------
K
Q
G
-------
Y
K
S
D
V
M
H
G
D
Y
K
T
F
W
N
-
R
D
Q
V
Y
K
H
F
----
G
I
D
K
F
Y
D
A
T
Y
Y
D
M
S
D
K
N
V
-
V
N
L
G
L
----
K
D
K
I
F
F
--
K
D
----
S
A
N
--
Y
Q
A
------
K
M
K
S
P
----------
F
Y
S
H
L
I
T
L
T
N
--
H
Y
P
F
T
------------
L
D
E
K
D
A
T
I
E
K
S
NTGD
A
T
V
--
D
-----
G
Y
I
Q
T
A
R
Y
L
D
E
A
L
E
E
Y
I
N
D
L
K
K
K
G
L
Y
D
N
S
V
I
M
I
Y
G
D
H
Y
--------------
G
-
I
S
----------------
E
N
H
-
N
----------------------------------------------------------------------------
N
-----
A
-------------
M
-
E
K
--------------
L
--
L
GEKIT
P
A
K
F
T
--
D
L
N
---------------
R
T
G
F
W
I
K
I
P
G
---
K
----
S
G
G
I
N
N
----
E
-
Y
-
A
--
G
Q
V
-
D
V
M
P
T
I
L
H
L
A
G
I
D
-----------
T
K
N
Y
L
M
F
---
G
T
D
L
F
S
K
G
---
H
---
N
Q
-----------------------------------------------------------------
V
V
---------------
P
F
R
N
G
D
--
F
I
-
T
----
K
D
---------
Y
K
Y
V
N
G
K
I
Y
S
N
K
N
N
E
L
I
T
T
Q
P
A
D
F
E
K
N
K
K
Q
V
E
K
D
L
E
M
---
S
D
N
V
L
N
G
D
L
F
R
F
Y
K
N
P
D
F
K
K
V
N
P
S
K
Y
K
Y
E
T
G
P
K
------------------------
4
PsiBlast_PDB
57.06
23%
-26
- C3 -
2QZU
-
?
A:
[27-452]
---
T
P
N
L
V
F
I
M
A
D
Q
Y
R
G
D
A
I
--
G
C
I
G
K
E
P
V
-
K
T
P
H
L
D
K
L
A
S
E
G
--
I
---
N
F
T
N
A
I
S
S
Y
-
P
--
V
S
S
P
A
R
G
M
L
M
--
T
G
M
Y
P
I
G
S
K
--
V
T
G
N
CNSETAPY
G
V
E
------
L
S
Q
---
N
---
A
------------------
R
C
W
S
D
V
L
-----------
K
-
D
Q
G
Y
N
M
G
Y
I
-
G
K
W
H
L
D
A
P
Y
K
PYVDTYNNRGKVAW
N
E
W
------------------------
C
-
P
--------------------
P
E
---------
R
--------
R
---
H
G
F
D
------
H
W
I
A
Y
----
G
T
Y
--
D
-
Y
H
L
-----
K
P
M
Y
W
----
N
-
T
T
A
----
P
R
-----
D
S
F
--
Y
Y
---------
V
N
Q
W
---------------------
G
P
-----------------
E
Y
E
A
S
K
A
I
E
Y
I
N
G
Q
K
D
Q
K
--
Q
P
F
A
L
V
V
S
M
N
P
P
H
T
G
Y
E
L
V
P
D
R
Y
K
E
I
Y
K
D
L
D
V
----------
E
A
--
L
C
K
------
G
R
P
D
I
----------
P
A
K
G
T
E
M
------------------------
G
D
Y
F
R
--------
N
N
I
--
R
-----
N
Y
Y
A
C
I
T
G
V
D
E
N
V
G
R
I
I
E
A
L
K
Q
N
N
L
F
D
N
T
I
V
V
F
T
S
D
H
G
--------------
I
-
C
M
----------------
G
A
H
-
E
----------------------------------------------------------------------------
N
-----
A
-------------
G
-
K
D
--------------
I
--
F
--------
Y
E
--
E
S
M
---------------
R
I
P
M
I
L
S
W
P
D
---
Q
--
I
-
K
P
R
K
S
D
----
P
L
M
-
I
--
A
F
A
-
D
L
Y
P
T
L
L
S
M
M
G
F
S
-----------
K
E
I
P
E
T
V
Q
--
T
F
D
L
S
N
E
V
---
L
---
T
G
K
N
--
K
-------------
K
---
D
---
L
V
-
Q
-
P
----
Y
Y
F
V
K
-
F
--
D
--
N
-
H
-----------
A
T
G
Y
R
---------------
G
L
R
T
D
R
Y
T
Y
A
-
V
H
A
T
D
G
K
I
D
-
N
-
V
I
--
L
F
D
R
T
N
D
P
H
E
M
N
N
I
A
S
Q
Q
L
K
L
T
H
T
F
N
R
Q
L
K
T
W
L
E
K
T
N
D
P
F
A
Q
Y
I
K
L
---------------------------------------------------
50
Fugue
54.70
18%
-54
- C3 -
2GSO
3
?
A:
[5-386]
--
T
P
H
A
L
L
L
I
S
I
D
G
L
R
A
D
M
L
--
D
R
G
I
------
T
P
N
L
S
H
L
A
R
E
G
--
V
---
R
A
R
W
M
A
P
S
Y
-
P
S-
L
T
F
P
N
H
Y
T
L
V
--
T
G
L
R
P
D
H
H
G
--
I
V
H
N
--------
S
M
R
------
D
P
T
---
L
---
G
------------------
G
F
W
L
S
K
S
-----------
E
-
A
V
G
D
A
R
W
W
G
-
G
E
P
V
----------------------
W
------------------------
V
-
G
--------------------
V
E
---------
N
--------------------------
T
----
G
Q
H
A
A
T
-
W
S
W
-----
P
G
S
E
A
----
A
-
I
K
G
----
V
R
-----
P
S
Q
--
W
R
-----
H
Y
Q
K
G
V
R
----------------------------------------
L
D
T
R
V
D
A
V
R
G
W
L
A
---
T
D
G
A
Q
R
N
R
L
V
T
L
Y
F
---------------------------
E
----
H
V
D
--
E
A
G
------
H
D
H
G
P
----------
E
S
-----------------------------------------------
R
-----
Q
Y
A
D
A
V
R
A
V
D
A
A
I
G
R
L
L
A
G
M
Q
R
D
G
T
R
A
R
T
N
I
I
V
V
S
D
H
G
--------------
M
-
A
E
----------------
V
A
P
-
G
----------------------------------------------------------------------------
H
-----
A
-------------
I
-
S
V
--------------
E
--
D
--------
I
A
--
P
P
Q
---------------
I
A
T
A
I
T
D
G
Q
V
---
I
--
G
-
F
E
P
L
P
G
----
Q
-
Q
-
A
--
A
A
E
-
A
S
V
L
G
A
H
D
H
Y
D
C
W
-----------
R
K
A
E
L
P
A
R
--
W
Q
---------------------------------------------------
Y
---
G
-
S
--
H
--
P
-
R
-----------
I
P
S
L
V
---------------
C
Q
M
H
E
G
W
D
A
L
-
F
----
P
D
K
L
-
A
-
K
R
--
A
Q
R
G
T
R
G
S
H
G
Y
D
P
--
A
L
P
S
M
R
A
V
F
L
A
Q
G
P
D
L
A
Q
G
K
T
L
P
G
F
D
-----------
N
V
D
V
Y
A
L
M
S
R
L
L
G
I
P
A
A
P
-
N
D
G
N
P
A
T
L
L
P
A
L
R
M
------------