@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0035: (2015-12-19 )
MSRLQTRFAQLKQENRAALVTFVTAGDPDYASSLEILKGLPAAGADVIELGMPFTDPMADGPAIQLANIRALDGGQTLARTLQMVREFRSGDSETPLVLMGYFNPIHHYGVERFIAEAKEVGVDGLIVVDLPPEHNEDLCHPAQAAGIDFIRLTTPTTGDQRLPTVLEGSSGFVYYVSVAGVTGANAATLEHVEEAVARLRRHTDLPIGIGFGIRSAEHAAAVARLADGVVVGSALIDRIAKARDNAQAVKDVLALCGELAEGVRNAR
Atome Classification :
(28 SA)
...-......10........20........30........-40.........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180....---...190-.......200.......210.......220...-.-...230-.......240.....-...250........260......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
S
R
-
L
Q
T
R
F
A
Q
L
K
QEN
R
A
A
L
V
T
F
V
TAGDP
D
Y
A
S
S
L
E
I
L
KG-L-PAAGAD
V
I
ELGMPFTDPMADGP
A
I
Q
L
A
N
I
R
ALDG
G
Q
T
L
A
R
T
L
Q
M
V
R
E
F
RSGDSET
P
L
V
L
M
GYFN
P
I
H
H
Y
G
V
E
R
F
I
A
E
A
K
EVGVD
G
L
I
V
V
DLPPEHNEDLCHP
A
Q
AAG
I
D
F
I
R
L
TTPTTGDQRL
P
T
VLEGSSG
F
V
Y
Y
V
S
VAGVTGA
N
---
A
A
T
L
E
H
-
V
E
E
A
V
A
R
L
R
RHTDLP
I
G
I
G
FGIRS
A
E
H
A
A
A
V
A
R
-L-AD
G
V
V
V
-
G
S
A
L
I
D
R
I
A
-KARD
N
-
A
Q
A
V
-
K
D
V
L
A
L
C
G
E
L
A
E
G
V
RNAR
2
PsiBlast_PDB
95.15
39%
-113
- C1 -
1RD5
2
TRPA_MAIZE
A:
[2-260]
-
S
R
P
V
S
D
T
M
A
A
L
M
A
K
G
K
T
A
F
I
P
Y
I
T
A
G
D
P
D
L
A
T
T
A
E
A
L
R
L
-
L
-
D
G
C
G
A
D
V
I
E
L
G
V
P
C
S
D
P
Y
I
D
G
P
I
I
Q
A
S
V
A
R
A
L
A
S
G
T
T
M
D
A
V
L
E
M
L
R
E
V
-
T
P
E
L
S
C
P
V
V
L
L
S
Y
Y
K
P
I
M
F
----
R
S
L
A
K
M
K
E
A
G
V
H
G
L
I
V
P
D
L
P
Y
V
A
A
H
S
L
W
S
E
A
K
N
N
N
L
E
L
V
L
L
T
T
P
A
I
P
E
D
R
M
K
E
I
T
K
A
S
E
G
F
V
Y
L
V
S
V
N
G
V
T
G
P
R
---
A
N
V
N
P
R
-
V
E
S
L
I
Q
E
V
K
K
V
T
N
K
P
V
A
V
G
F
G
I
S
K
P
E
H
V
K
Q
I
A
Q
-
W
G
A
D
G
V
I
I
-
G
S
A
M
V
R
Q
L
G
-
E
A
A
S
P
-
K
Q
G
L
-
R
R
L
----
E
E
Y
A
R
G
M
K
N
A
L
103
HHSearch
94.20
38%
-120
- C1 -
2EKC
-
TRPA_AQUAE
A:
[1-262]
M
G
R
-
I
S
D
K
F
T
E
L
K
E
K
R
E
K
A
L
V
S
Y
L
M
V
G
Y
P
D
Y
E
T
S
L
K
A
F
K
E
-
V
-
L
K
N
G
T
D
I
L
E
I
G
F
P
F
S
D
P
V
A
D
G
P
T
I
Q
V
A
H
E
V
A
L
K
N
G
I
R
F
E
D
V
L
E
L
S
E
T
L
R
K
E
F
P
D
I
P
F
L
L
M
T
Y
Y
N
P
I
F
R
I
G
L
E
K
F
C
R
L
S
R
E
K
G
I
D
G
F
I
V
P
D
L
P
P
E
E
A
E
E
L
K
A
V
M
K
K
Y
V
L
S
F
V
P
L
G
A
P
T
S
T
R
K
R
I
K
L
I
C
E
A
A
D
E
M
T
Y
F
V
S
V
T
G
------------
Y
E
R
I
K
K
K
V
E
E
Y
R
E
L
C
D
K
P
V
V
V
G
F
G
V
S
K
K
E
H
A
R
E
I
G
S
-
F
-
A
D
G
V
V
V
-
G
S
A
L
V
K
L
A
G
-
Q
K
K
------
I
-
E
D
L
G
N
L
V
K
E
L
K
E
G
L
R
E
--
108
HHSearch
94.08
38%
-118
- C1 -
1RD5
2
TRPA_MAIZE
A:
[6-260]
-----
S
D
T
M
A
A
L
M
A
K
G
K
T
A
F
I
P
Y
I
T
A
G
D
P
D
L
A
T
T
A
E
A
L
R
L
-
L
-
D
G
C
G
A
D
V
I
E
L
G
V
P
C
S
D
P
Y
I
D
G
P
I
I
Q
A
S
V
A
R
A
L
A
S
G
T
T
M
D
A
V
L
E
M
L
R
E
V
T
P
E
-
L
S
C
P
V
V
L
L
S
Y
Y
K
P
I
M
----
F
R
S
L
A
K
M
K
E
A
G
V
H
G
L
I
V
P
D
L
P
Y
V
A
A
H
S
L
W
S
E
A
K
N
N
N
L
E
L
V
L
L
T
T
P
A
I
P
E
D
R
M
K
E
I
T
K
A
S
E
G
F
V
Y
L
V
S
V
N
G
V
T
G
P
R
---
A
N
V
N
P
R
-
V
E
S
L
I
Q
E
V
K
K
V
T
N
K
P
V
A
V
G
F
G
I
S
K
P
E
H
V
K
Q
I
A
Q
W
G
-
A
D
G
V
I
I
-
G
S
A
M
V
R
Q
L
G
-
E
A
A
S
P
-
K
Q
G
L
-
R
R
L
E
E
Y
A
R
G
M
K
N
A
L
G
---
21
PsiBlast_CBE
93.85
39%
-111
- C1 -
1RD5
2
TRPA_MAIZE
B:
[2-260]
-
S
R
P
V
S
D
T
M
A
A
L
M
A
K
G
K
T
A
F
I
P
Y
I
T
A
G
D
P
D
L
A
T
T
A
E
A
L
R
L
-
L
-
D
G
C
G
A
D
V
I
E
L
G
V
P
C
S
D
P
--
D
G
P
I
I
Q
A
S
V
A
R
A
L
A
S
G
T
T
M
D
A
V
L
E
M
L
R
E
V
-
T
P
E
L
S
C
P
V
V
L
L
S
Y
Y
K
P
I
M
F
----
R
S
L
A
K
M
K
E
A
G
V
H
G
L
I
V
P
D
L
P
Y
V
A
A
H
S
L
W
S
E
A
K
N
N
N
L
E
L
V
L
L
T
T
P
A
I
P
E
D
R
M
K
E
I
T
K
A
S
E
G
F
V
Y
L
V
S
V
--------------
P
R
-
V
E
S
L
I
Q
E
V
K
K
V
T
N
K
P
V
A
V
G
F
G
I
S
K
P
E
H
V
K
Q
I
A
Q
-
W
G
A
D
G
V
I
I
-
G
S
A
M
V
R
Q
L
G
-
E
A
A
S
P
-
K
Q
G
L
-
R
R
L
----
E
E
Y
A
R
G
M
K
N
A
L
4
PsiBlast_PDB
93.76
43%
-123
- C1 -
2DZW
-
TRPA_PYRFU
A:
[6-247]
------------------
S
L
I
P
Y
L
T
A
G
D
P
D
K
Q
S
T
L
N
F
L
L
A
-
L
D
E
Y
A
G
A
--
I
E
L
G
I
P
F
S
D
P
I
A
D
G
K
T
I
Q
E
S
H
Y
R
A
L
K
N
G
F
K
L
R
E
A
F
W
I
V
K
E
F
R
R
-
H
S
S
T
P
I
V
L
M
T
Y
Y
N
P
I
Y
R
A
G
V
R
N
F
L
A
E
A
K
A
S
G
V
D
G
I
L
V
V
D
L
P
V
F
H
A
K
E
F
T
E
I
A
R
E
E
G
I
K
T
V
F
L
A
A
P
N
T
P
D
E
R
L
K
V
I
D
D
M
T
T
G
F
V
Y
L
V
S
L
Y
G
T
-------
E
E
I
P
K
T
-
A
Y
D
L
L
R
R
A
K
R
I
C
R
N
K
V
A
V
G
F
G
V
S
K
R
E
H
V
V
S
L
L
K
-
E
G
A
N
G
V
V
V
-
G
S
A
L
V
K
I
I
G
E
K
G
R
E
A
-
T
E
F
L
K
K
K
V
E
A
L
L
G
I
---------
93
Fugue
93.74
40%
-124
- C1 -
1GEQ
-
TRPA_PYRFU
A:
[1-248]
-------
M
F
K
------
D
G
S
L
I
P
Y
L
T
A
G
D
P
D
K
Q
S
T
L
N
F
L
L
A
-
L
-
D
E
Y
-
A
G
A
I
E
L
G
I
P
F
S
D
P
I
A
D
G
K
T
I
Q
E
S
H
Y
R
A
L
K
N
G
F
K
L
R
E
A
F
W
I
V
K
E
F
R
R
H
S
-
S
T
P
I
V
L
M
T
Y
Y
N
P
I
Y
R
A
G
V
R
N
F
L
A
E
A
K
A
S
G
V
D
G
I
L
V
V
D
L
P
V
F
H
A
K
E
F
T
E
I
A
R
E
E
G
I
K
T
V
F
L
A
A
P
N
T
P
D
E
R
L
K
V
I
D
D
M
T
T
G
F
V
Y
L
V
S
L
Y
-----
E
-----
I
P
K
T
-
A
Y
D
L
L
R
R
A
K
R
I
C
R
N
K
V
A
V
G
F
G
V
S
K
R
E
H
V
V
S
L
L
K
E
G
-
A
N
G
V
V
V
-
G
S
A
L
V
K
I
I
G
-
E
K
--
G
-
R
E
A
T
-
E
F
L
K
K
K
V
E
E
L
L
G
I
-----
1
PsiBlast_PDB
93.61
37%
-124
- C1 -
2EKC
-
TRPA_AQUAE
A:
[1-262]
M
G
R
-
I
S
D
K
F
T
E
L
K
E
K
R
E
K
A
L
V
S
Y
L
M
V
G
Y
P
D
Y
E
T
S
L
K
A
F
K
E
-
V
-
L
K
N
G
T
D
I
L
E
I
G
F
P
F
S
D
P
V
A
D
G
P
T
I
Q
V
A
H
E
V
A
L
K
N
G
I
R
F
E
D
V
L
E
L
S
E
T
L
R
K
E
F
P
D
I
P
F
L
L
M
T
Y
Y
N
P
I
F
R
I
G
L
E
K
F
C
R
L
S
R
E
K
G
I
D
G
F
I
V
P
D
L
P
P
E
E
A
E
E
L
K
A
V
M
K
K
Y
V
L
S
F
V
P
L
G
A
P
T
S
T
R
K
R
I
K
L
I
C
E
A
A
D
E
M
T
Y
F
V
S
V
T
G
-----------
Y
E
R
-
I
K
K
K
V
E
E
Y
R
E
L
C
D
K
P
V
V
V
G
F
G
V
S
K
K
E
H
A
R
E
I
G
S
-
F
-
A
D
G
V
V
V
-
G
S
A
L
V
-
K
L
A
-----
G
-
Q
K
K
I
-
E
D
L
G
N
L
V
K
E
L
K
E
G
L
R
E
--
11
PsiBlast_PDB
93.09
39%
-105
- C1 -
1TJR
1
TRPA_MAIZE
A:
[9-259]
---------
A
A
L
M
A
K
G
K
T
A
F
I
P
Y
I
T
A
G
D
P
D
L
A
T
T
A
E
A
L
R
L
-
L
-
D
G
C
G
A
D
V
I
E
L
G
V
P
C
S
D
P
Y
I
D
G
P
I
I
Q
A
S
V
A
R
A
L
A
S
G
T
T
M
D
A
V
L
E
M
L
R
E
V
-
T
P
E
L
S
C
P
V
V
L
L
S
Y
Y
K
P
I
M
S
----
R
S
L
A
E
M
K
E
A
G
V
H
G
L
I
V
P
D
L
P
Y
V
A
A
H
S
L
W
S
E
A
K
N
N
N
L
E
L
V
L
L
T
T
P
A
I
P
E
D
R
M
K
E
I
T
K
A
S
E
G
F
V
Y
L
V
S
V
N
G
V
T
G
P
R
---
A
N
V
N
P
R
-
V
E
S
L
I
Q
E
V
K
K
V
T
N
K
P
V
A
V
G
F
G
I
S
K
P
E
H
V
K
Q
I
A
Q
-
W
G
A
D
G
V
I
I
-
G
S
A
M
V
R
Q
L
G
-
E
A
A
S
P
-
K
Q
G
L
-
R
R
L
----
E
E
Y
A
R
G
M
K
N
A
L
5
PsiBlast_PDB
92.22
43%
-125
- C1 -
1GEQ
-
TRPA_PYRFU
A:
[6-239]
------------------
S
L
I
P
Y
L
T
A
G
D
P
D
K
Q
S
T
L
N
F
L
L
A
-
L
D
E
Y
A
G
A
--
I
E
L
G
I
P
F
S
D
P
I
A
D
G
K
T
I
Q
E
S
H
Y
R
A
L
K
N
G
F
K
L
R
E
A
F
W
I
V
K
E
F
R
R
-
H
S
S
T
P
I
V
L
M
T
Y
Y
N
P
I
Y
R
A
G
V
R
N
F
L
A
E
A
K
A
S
G
V
D
G
I
L
V
V
D
L
P
V
F
H
A
K
E
F
T
E
I
A
R
E
E
G
I
K
T
V
F
L
A
A
P
N
T
P
D
E
R
L
K
V
I
D
D
M
T
T
G
F
V
Y
L
V
S
L
Y
----------
E
I
P
K
T
-
A
Y
D
L
L
R
R
A
K
R
I
C
R
N
K
V
A
V
G
F
G
V
S
K
R
E
H
V
V
S
L
L
K
-
E
G
A
N
G
V
V
V
-
G
S
A
L
V
K
I
I
G
E
K
G
R
E
A
-
T
E
F
L
-
K
K
K
V
E
E
L
L
G
I
--------
7
PsiBlast_PDB
92.14
41%
-125
- C1 -
1UJP
1
TRPA_THET2
A:
[7-249]
--------
F
A
K
A
R
S
E
G
R
A
A
L
I
P
Y
L
T
A
G
F
P
S
R
E
G
F
L
Q
A
V
E
E
V
L
-
P
Y
A
--
D
L
L
E
I
G
L
P
Y
S
D
----
G
P
V
I
Q
R
A
S
E
L
A
L
R
K
G
M
S
V
Q
G
A
L
E
L
V
R
E
V
R
A
-
L
T
E
K
P
L
F
L
M
T
Y
L
N
P
V
L
A
W
G
P
E
R
F
F
G
L
F
K
Q
A
G
A
T
G
V
I
L
P
D
L
P
P
D
E
D
P
G
L
V
R
L
A
Q
E
I
G
L
E
T
V
F
L
L
A
P
T
S
T
D
A
R
I
A
T
V
V
R
H
A
T
G
F
V
Y
A
V
S
V
---------------
E
-
V
K
D
L
V
R
R
I
K
A
R
T
A
L
P
V
A
V
G
F
G
V
-
S
G
K
A
T
A
A
Q
A
A
-
V
-
A
D
G
V
V
V
-
G
S
A
L
V
R
A
L
E
-
E
G
R
S
L
-
A
P
L
L
-
Q
E
I
R
Q
G
L
Q
R
L
P
L
P
-----
8
PsiBlast_PDB
91.35
41%
-122
- C1 -
1WXJ
5
TRPA_THET2
A:
[7-249]
--------
F
A
K
A
R
S
E
G
R
A
A
L
I
P
Y
L
T
A
G
F
P
S
R
E
G
F
L
Q
A
V
E
E
V
L
-
P
Y
A
--
D
L
L
E
I
G
L
P
Y
S
-----
G
P
V
I
Q
R
A
S
E
L
A
L
R
K
G
M
S
V
Q
G
A
L
E
L
V
R
E
V
R
A
-
L
T
E
K
P
L
F
L
M
T
Y
L
N
P
V
L
A
W
G
P
E
R
F
F
G
L
F
K
Q
A
G
A
T
G
V
I
L
P
D
L
P
P
D
E
D
P
G
L
V
R
L
A
Q
E
I
G
L
E
T
V
F
L
L
A
P
T
S
T
D
A
R
I
A
T
V
V
R
H
A
T
G
F
V
Y
A
V
S
----------------
E
-
V
K
D
L
V
R
R
I
K
A
R
T
A
L
P
V
A
V
G
F
G
V
-
S
G
K
A
T
A
A
Q
A
A
-
V
-
A
D
G
V
V
V
-
G
S
A
L
V
R
A
L
E
-
E
G
R
S
L
-
A
P
L
L
-
Q
E
I
R
Q
G
L
Q
R
L
E
-------
9
PsiBlast_PDB
90.58
42%
-121
- C1 -
2DZP
-
TRPA_PYRFU
A:
[6-239]
------------------
S
L
I
P
Y
L
T
A
G
D
P
N
K
Q
S
T
L
N
F
L
L
A
-
L
D
E
Y
A
G
A
--
I
E
L
G
I
P
F
S
D
P
I
A
D
G
K
T
I
Q
E
S
H
Y
R
A
L
K
N
G
F
K
L
R
E
A
F
W
I
V
K
E
F
R
R
-
H
S
S
T
P
I
V
L
M
T
Y
Y
N
P
I
Y
R
A
G
V
R
N
F
L
A
E
A
K
A
S
G
V
D
G
I
L
V
V
D
L
P
V
F
H
A
K
E
F
T
E
I
A
R
E
E
G
I
K
T
V
F
L
A
A
P
N
T
P
D
E
R
L
K
V
I
D
D
M
T
T
G
F
V
Y
L
V
S
L
Y
G
T
-------
E
E
I
P
K
T
-
A
Y
D
L
L
R
R
A
K
R
I
C
R
N
K
V
A
V
G
F
G
V
S
K
R
E
H
V
V
S
L
L
K
-
E
G
A
N
G
V
V
V
-
G
S
A
L
V
K
I
I
G
E
K
G
R
E
A
-
T
E
F
L
-
K
K
K
V
E
E
L
L
G
I
--------
10
PsiBlast_PDB
90.51
42%
-122
- C1 -
2DZU
-
TRPA_PYRFU
A:
[6-239]
------------------
S
L
I
P
Y
L
T
A
G
D
P
D
K
Q
S
T
L
N
F
L
L
A
-
L
D
E
Y
A
G
A
--
I
E
L
G
I
P
F
S
D
P
I
A
D
G
K
T
I
Q
E
S
H
Y
R
A
L
K
N
G
F
K
L
R
E
A
F
W
I
V
K
E
F
R
R
-
H
S
S
T
P
I
V
L
M
T
Y
Y
N
P
I
Y
R
A
G
V
R
N
F
L
A
E
A
K
A
S
G
V
N
G
I
L
V
V
D
L
P
V
F
H
A
K
E
F
T
E
I
A
R
E
E
G
I
K
T
V
F
L
A
A
P
N
T
P
D
E
R
L
K
V
I
D
D
M
T
T
G
F
V
Y
L
V
S
L
Y
G
T
-------
E
E
I
P
K
T
-
A
Y
D
L
L
R
R
A
K
R
I
C
R
N
K
V
A
V
G
F
G
V
S
K
R
E
H
V
V
S
L
L
K
-
E
G
A
N
G
V
V
V
-
G
S
A
L
V
K
I
I
G
E
K
G
R
E
A
-
T
E
F
L
-
K
K
K
V
E
E
L
L
G
I
--------
6
PsiBlast_PDB
90.17
43%
-121
- C1 -
1WDW
-
TRPA_PYRFU
A:
[6-239]
------------------
S
L
I
P
Y
L
T
A
G
D
P
D
K
Q
S
T
L
N
F
L
L
A
-
L
D
E
Y
A
G
A
--
I
E
L
G
I
P
F
S
D
P
I
A
D
G
K
T
I
Q
E
S
H
Y
R
A
L
K
N
G
F
K
L
R
E
A
F
W
I
V
K
E
F
R
R
-
H
S
S
T
P
I
V
L
M
T
Y
Y
N
P
I
Y
R
A
G
V
R
N
F
L
A
E
A
K
A
S
G
V
D
G
I
L
V
V
D
L
P
V
F
H
A
K
E
F
T
E
I
A
R
E
E
G
I
K
T
V
F
L
A
A
P
N
T
P
D
E
R
L
K
V
I
D
D
M
T
T
G
F
V
Y
L
V
S
L
Y
---------
E
E
I
P
K
T
-
A
Y
D
L
L
R
R
A
K
R
I
C
R
N
K
V
A
V
G
F
G
V
S
K
R
E
H
V
V
S
L
L
K
-
E
G
A
N
G
V
V
V
-
G
S
A
L
V
K
I
I
G
E
K
G
R
E
A
-
T
E
F
L
-
K
K
K
V
E
E
L
L
G
---------
14
PsiBlast_PDB
90.13
42%
-126
- C1 -
2DZT
-
TRPA_PYRFU
A:
[6-239]
------------------
S
L
I
P
Y
L
T
A
G
D
P
D
K
Q
S
T
L
N
F
L
L
A
-
L
D
E
Y
A
G
A
--
I
E
L
G
I
P
F
S
D
P
I
A
D
G
K
T
I
Q
E
S
H
Y
R
A
L
K
N
G
F
K
L
R
E
A
F
W
I
V
K
E
F
R
R
-
H
S
S
T
P
I
V
L
M
T
Y
Y
N
P
I
Y
R
A
G
V
R
N
F
L
A
E
A
K
A
S
G
V
A
G
I
L
V
V
D
L
P
V
F
H
A
K
E
F
T
E
I
A
R
E
E
G
I
K
T
V
F
L
A
A
P
N
T
P
D
E
R
L
K
V
I
D
D
M
T
T
G
F
V
Y
L
V
S
L
Y
G
T
-------
E
E
I
P
K
T
-
A
Y
D
L
L
R
R
A
K
R
I
C
R
N
K
V
A
V
G
F
G
V
S
K
R
E
H
V
V
S
L
L
K
-
E
G
A
N
G
V
V
V
-
G
S
A
L
V
K
I
I
G
E
K
G
R
E
A
-
T
E
F
L
-
K
K
K
V
E
E
L
L
G
I
--------
13
PsiBlast_PDB
90.13
42%
-118
- C1 -
2E09
-
TRPA_PYRFU
A:
[6-239]
------------------
S
L
I
P
Y
L
T
A
G
D
P
D
K
Q
S
T
L
N
F
L
L
A
-
L
D
E
Y
A
G
A
--
I
E
L
G
I
P
F
S
D
P
I
A
D
G
K
T
I
Q
E
S
H
Y
R
A
L
K
N
G
F
K
L
R
E
A
F
W
I
V
K
A
F
R
R
-
H
S
S
T
P
I
V
L
M
T
Y
Y
N
P
I
Y
R
A
G
V
R
N
F
L
A
E
A
K
A
S
G
V
D
G
I
L
V
V
D
L
P
V
F
H
A
K
E
F
T
E
I
A
R
E
E
G
I
K
T
V
F
L
A
A
P
N
T
P
D
E
R
L
K
V
I
D
D
M
T
T
G
F
V
Y
L
V
S
L
Y
G
T
-------
E
E
I
P
K
T
-
A
Y
D
L
L
R
R
A
K
R
I
C
R
N
K
V
A
V
G
F
G
V
S
K
R
E
H
V
V
S
L
L
K
-
E
G
A
N
G
V
V
V
-
G
S
A
L
V
K
I
I
G
E
K
G
R
E
A
-
T
E
F
L
-
K
K
K
V
E
E
L
L
G
I
--------
3
PsiBlast_PDB
90.11
43%
-119
- C1 -
2DZX
-
TRPA_PYRFU
A:
[6-239]
------------------
S
L
I
P
Y
L
T
A
G
D
P
D
K
Q
S
T
L
N
F
L
L
A
-
L
D
E
Y
A
G
A
--
I
E
L
G
I
P
F
S
D
P
I
A
D
G
K
T
I
Q
E
S
H
Y
R
A
L
K
N
G
F
K
L
R
E
A
F
W
I
V
K
E
F
R
R
-
H
S
S
T
P
I
V
L
M
T
Y
Y
N
P
I
Y
R
A
G
V
R
N
F
L
A
E
A
K
A
S
G
V
D
G
I
L
V
V
D
L
P
V
F
H
A
K
E
F
T
E
I
A
R
A
A
G
I
K
T
V
F
L
A
A
P
N
T
P
D
E
R
L
K
V
I
D
D
M
T
T
G
F
V
Y
L
V
S
L
Y
G
T
-------
E
E
I
P
K
T
-
A
Y
D
L
L
R
R
A
K
R
I
C
R
N
K
V
A
V
G
F
G
V
S
K
R
E
H
V
V
S
L
L
K
-
E
G
A
N
G
V
V
V
-
G
S
A
L
V
K
I
I
G
E
K
G
R
E
A
-
T
E
F
L
-
K
K
K
V
E
E
L
L
G
I
--------
105
HHSearch
90.06
41%
-127
* C1 *
1UJP
1
TRPA_THET2
A:
[5-239]
------
E
A
F
A
K
A
R
S
E
G
R
A
A
L
I
P
Y
L
T
A
G
F
P
S
R
E
G
F
L
Q
A
V
E
E
-
V
-
L
-
P
Y
A
D
L
L
E
I
G
L
P
Y
S
D
----
G
P
V
I
Q
R
A
S
E
L
A
L
R
K
G
M
S
V
Q
G
A
L
E
L
V
R
E
V
R
A
L
-
T
E
K
P
L
F
L
M
T
Y
L
N
P
V
L
A
W
G
P
E
R
F
F
G
L
F
K
Q
A
G
A
T
G
V
I
L
P
D
L
P
P
D
E
D
P
G
L
V
R
L
A
Q
E
I
G
L
E
T
V
F
L
L
A
P
T
S
T
D
A
R
I
A
T
V
V
R
H
A
T
G
F
V
Y
A
V
S
V
---------------
E
-
V
K
D
L
V
R
R
I
K
A
R
T
A
L
P
V
A
V
G
F
G
V
S
G
K
A
T
A
A
Q
A
-
A
-
V
-
A
D
G
V
V
V
-
G
S
A
L
V
R
A
L
E
-
E
G
R
S
L
-
A
P
L
L
-
Q
E
I
R
Q
G
L
Q
R
L
P
L
P
-----
15
PsiBlast_PDB
89.93
42%
-121
- C1 -
2DZV
-
TRPA_PYRFU
A:
[6-239]
------------------
S
L
I
P
Y
L
T
A
G
D
P
D
K
Q
S
T
L
N
F
L
L
A
-
L
D
E
Y
A
G
A
--
I
E
L
G
I
P
F
S
D
P
I
A
D
G
K
T
I
Q
E
S
H
Y
R
A
L
K
N
G
F
K
L
R
E
A
F
W
I
V
K
E
F
R
R
-
H
S
S
T
P
I
V
L
M
T
Y
Y
N
P
I
Y
R
A
G
V
R
N
F
L
A
E
A
K
A
S
G
V
D
G
I
L
V
V
D
L
P
V
F
H
A
K
E
F
T
E
I
A
R
E
E
G
I
K
T
V
F
L
A
A
P
N
T
P
A
E
R
L
K
V
I
D
D
M
T
T
G
F
V
Y
L
V
S
L
Y
G
T
-------
E
E
I
P
K
T
-
A
Y
D
L
L
R
R
A
K
R
I
C
R
N
K
V
A
V
G
F
G
V
S
K
R
E
H
V
V
S
L
L
K
-
E
G
A
N
G
V
V
V
-
G
S
A
L
V
K
I
I
G
E
K
G
R
E
A
-
T
E
F
L
-
K
K
K
V
E
E
L
L
G
I
--------
12
PsiBlast_PDB
89.78
42%
-121
- C1 -
2DZS
-
TRPA_PYRFU
A:
[6-239]
------------------
S
L
I
P
Y
L
T
A
G
D
P
D
K
Q
S
T
L
N
F
L
L
A
-
L
D
E
Y
A
G
A
--
I
E
L
G
I
P
F
S
D
P
I
A
D
G
K
T
I
Q
E
S
H
Y
R
A
L
K
N
G
F
K
L
R
E
A
F
W
I
V
K
E
F
R
R
-
H
S
S
T
P
I
V
L
M
T
Y
Y
N
P
I
Y
R
A
G
V
R
N
F
L
A
A
A
K
A
S
G
V
D
G
I
L
V
V
D
L
P
V
F
H
A
K
E
F
T
E
I
A
R
E
E
G
I
K
T
V
F
L
A
A
P
N
T
P
D
E
R
L
K
V
I
D
D
M
T
T
G
F
V
Y
L
V
S
L
Y
G
T
-------
E
E
I
P
K
T
-
A
Y
D
L
L
R
R
A
K
R
I
C
R
N
K
V
A
V
G
F
G
V
S
K
R
E
H
V
V
S
L
L
K
-
E
G
A
N
G
V
V
V
-
G
S
A
L
V
K
I
I
G
E
K
G
R
E
A
-
T
E
F
L
-
K
K
K
V
E
E
L
L
G
I
--------
32
PsiBlast_CBE
86.45
37%
-106
- C1 -
3CEP
1
TRPA_SALTY
A:
[2-253]
-
E
R
-
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
-
L
-
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
I
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
NRG
A
L
P
L
H
H
-
L
I
E
---
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
-
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
-
K
---
N
-
L
A
S
P
-
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
A
S
65
PsiBlast_CBE
85.98
37%
-103
- C1 -
1C29
1
TRPA_SALTY
A:
[2-253]
-
E
R
-
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
-
L
-
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
NRG--
P
L
H
H
-
L
I
E
---
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
-
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
-
K
---
N
-
L
A
S
P
-
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
A
S
64
PsiBlast_CBE
85.49
37%
-101
- C1 -
1C8V
1
TRPA_SALTY
A:
[2-253]
-
E
R
-
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
-
L
-
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
NRG--
P
L
H
H
-
L
I
E
---
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
-
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
-
K
---
N
-
L
A
S
P
-
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
A
S
53
PsiBlast_CBE
85.45
37%
-105
- C1 -
1TJP
1
TRPA_SALTY
A:
[1-253]
M
E
R
-
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
-
L
-
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
NRG
A
L
P
L
H
H
-
L
I
E
---
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
-
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
-
K
---
N
-
L
A
S
P
-
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
A
S
55
PsiBlast_CBE
85.00
37%
-105
- C1 -
1K8Z
1
TRPA_SALTY
A:
[1-253]
M
E
R
-
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
-
L
-
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
-----------
A
L
P
L
H
H
-
L
I
E
---
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
-
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
-
K
---
N
-
L
A
S
P
-
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
A
S
106
HHSearch
84.91
34%
-108
- C1 -
3NAV
1
TRPA_VIBCH
A:
[5-270]
-
N
R
-
Y
Q
A
L
F
Q
R
L
S
A
A
Q
Q
G
A
F
V
P
F
V
T
I
G
D
P
N
P
E
Q
S
L
A
I
M
Q
T
-
L
-
I
D
A
G
A
D
A
L
E
L
G
M
P
F
S
D
P
L
A
D
G
P
T
I
Q
G
A
N
L
R
A
L
A
A
K
T
T
P
D
I
C
F
E
L
I
A
Q
I
R
A
R
N
P
E
T
P
I
G
L
L
M
Y
A
N
L
V
Y
A
R
G
I
D
D
F
Y
Q
R
C
Q
K
A
G
V
D
S
V
L
I
A
D
V
P
T
N
E
S
Q
P
F
V
A
A
A
E
K
F
G
I
Q
P
I
F
I
A
P
P
T
A
S
D
E
T
L
R
A
V
A
Q
L
G
K
G
Y
T
Y
L
L
S
R
A
-----------
A
N
M
P
-
V
H
A
L
L
E
R
L
Q
Q
F
D
A
P
P
A
L
L
G
F
G
I
S
E
P
A
Q
V
K
Q
A
I
E
A
G
-
A
A
G
A
I
S
-
G
S
A
V
V
K
I
I
E
-
T
H
L
D
N
P
A
K
Q
L
-
T
E
L
A
N
F
T
Q
A
M
K
K
A
T
K
I
--
60
PsiBlast_CBE
84.91
37%
-102
- C1 -
1FUY
1
TRPA_SALTY
A:
[1-253]
M
E
R
-
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
-
L
-
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N-----
L
H
H
-
L
I
E
---
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
-
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
-
K
---
N
-
L
A
S
P
-
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
A
S
42
PsiBlast_CBE
84.73
37%
-100
- C1 -
2TRS
1
TRPA_SALTY
A:
[1-253]
M
E
R
-
Y
E
N
L
F
A
Q
L
N
D
R
R
E
G
A
F
V
P
F
V
T
L
G
D
P
G
I
E
Q
S
L
K
I
I
D
T
-
L
-
I
D
A
G
A
D
A
L
E
L
G
V
P
F
S
D
P
L
A
D
G
P
T
I
Q
N
A
N
L
R
A
F
A
A
G
V
T
P
A
Q
C
F
E
M
L
A
L
I
R
E
K
H
P
T
I
P
I
G
L
L
M
Y
A
N
L
V
F
N
N
G
I
D
A
F
Y
A
R
C
E
Q
V
G
V
D
S
V
L
V
A
D
V
P
V
E
E
S
A
P
F
R
Q
A
A
L
R
H
N
I
A
P
I
F
I
C
P
P
N
A
D
D
D
L
L
R
Q
V
A
S
Y
G
R
G
Y
T
Y
L
L
S
R
S
G
V
T
G
A
E
N------
H
H
-
L
I
E
---
K
L
K
E
Y
H
A
A
P
A
L
Q
G
F
G
I
S
S
P
E
Q
V
S
A
A
V
R
-
A
-
G
A
A
G
A
I
S
G
S
A
I
V
K
I
I
E
-
K
---
N
-
L
A
S
P
-
K
Q
M
L
A
E
L
R
S
F
V
S
A
M
K
A
A
S