@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0049: (2015-12-19 )
MRYARHASRYSLFTLAVSAALLPGAGWAANGDLAGARKPPSVACSWNREAALSYEERRLDTPLPFSGANVVTHDQTPLAERIVKGAGFDGFEPAFAKRLCAADGRTPVTSYAKALKLVTEEGRALWRAAVDRAQGRRAIPAGALPASDDRMLYWTRLYMTRTLRQWAPSFHLGKAQAQALQWRFERASRGQLDIDLPRRYAADGSRYRRMIISGFDVFTLGTPGTANTGLRNGNPSGATALALDGREFRLADGSLLRIEAYLLPVSYDPFNRGMQEDTLGPWFRPGPRRVDASITISQGGANQFWLEAWNGRFHGSSAGNDGIVYCPADSALPNYVLPLGSVTNPGTAPISLRGSGCNINPPRRWLGYDSASRWRQNLPAQFSKASLPVRQLLAADTWRGIERPPGATSQAAEGFDVTWHTNYDFFPDCANPRTENVPTNGVMNAMPDPSLVLPPNRRICARNGGGGDYLSNESAYRNTVLRDAFRLEIPAGHIHVPVMNNYYTGVPASGGGARNDNAISDARYEAYRSAIVAQTRALLVGVGNALAQGAQAD
Atome Classification :
(20 SA)
------------------------------------------.........10........20........30........40........50........60........70........80....----------....90........100-.........110--.......120..--.....130------........140.......150..-..--...160....--..-.170--------........180.......190.......200......---.210.......220.....-..230.......240.......250.......260.....-..270..-----.....280..--.....290...-...-.300.......310....-...320.------......-----330---.....-------..340.......350-------.......360....----...370.......380--........390...---....400---.......-----..410.......420.......430..---.....440......-.450.......460..-------.....470--.......480.......490.........500....--.--..510-----........520.......530...--....540.......550.--------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------------------------------MRY
A
R
HASR
Y
S
L
F
T
L
A
V
S
A
A
LLPGAGWAANGDLAGARKP
P
S
V
A
C
SWNREAAL
S
Y
E
E
RRLDTPLPFSGANVVTHDQT
P
L
A
E
R
I
V
KG----------AGFDGF
E
P
A
F
A
K
R
L
C
---AADGRT
P
V
T
S
Y
A
--
K
A
L
K
L
V
T
EE
G
R
A
--
L
W
R
A
A
V
D
-------
R
AQGRRAIPAGALPASDD
R
M
L
Y
W
-
T
R
--
L
Y
M
T
R
T
L
R
Q
W--AP-SFH---------L
G
K
A
Q
A
Q
A
L
Q
W
R
F
E
RASRGQLDIDL
P
R
RYAAD
G
S
R
Y
R
---
R
M
I
ISG
F
D
V
F
T
LGTPGTAN-TGLRNGNPSG
A
T
A
L
A
LDG
R
E
F
RLADG
S
L
L
R
I
E
A
Y
L
L
PVSY-
D
P
F
NRGM-----QEDTLGPWFR--PGP
R
R
V
D
A
S
I
T
-
I
SQ-GGAN
Q
F
W
L
E
AWN
G
R
FHGS-SAGND
G
I
------
V
Y
CPAD-----SAL---PN
Y
V
L
-------PLGSVTNPGTA
P
I
S
L
-------RGSGCNINP
P
R
RWL----GYD
S
A
S
R
W
R
Q
NLP
A
Q
---FSKAS
L
P
V
R
Q
L
L
A
A
---
D
TWRG-----IERPPGA-----TSQAAE
G
F
D
V
T
W
HTNYDFFPDCANPRT---ENVPTNGVMNAMPD-P
S
L
VLPPN
R
R
I
C
ARNG-------GGGDYLSN--
E
S
A
Y
R
N
T
V
L
R
D
A
F
R
L
EIP--AG
H
I
H
V
P
V
MNNYYTGV--P--ASGG------GARNDNA
I
S
D
A
R
Y
E
A
Y
R
S
A
I
V
A
Q
T
--
R
A
L
L
V
G
V
G
N
A
L
AQGAQAD--------------------
21
Fugue
85.68
19%
-30
- C2 -
4C3X
9
?
A:
[23-530]
----------------------------------------------
D
W
T
S
E
C
D
V
L
V
V
G
S
G
G
G
A
L
T
G
A
Y
T
A
A
A
Q
G
L
---------------
T
T
I
V
L
E
K
T
D
R
F
G
G
T
S
A
Y
S
G
A
S
I
W
L
P
G
-
T
Q
V
Q
E
R
A
G
L
P
----------
D
S
T
E
N
A
R
T
Y
L
R
A
L
L
G
DAE
S
E
R
Q
D
A
Y
V
E
T
A
P
--
A
V
V
A
L
L
E
Q
N
P
N
I
E
F
E
F
R
A
F
P
D
YYKAEGR
M
D
T
G
R
S
I
N
P
L
D
L
D
P
A
D
I
G
D
L
A
G
K
-
V
R
PE
L
D
Q
D
R
T
G
Q
D
H
--
A
P
-
G
P
M
---------
I
G
---
G
R
A
L
I
G
R
L
L
A
A
V
Q
S
T
G
K
A
E
L
R
T
E
S
V
L
T
S
L
I
V
E
---
D
G
R
V
V
G
A
E
V
E
S
G
G
E
T
Q
R
I
K
-
A
N
R
G
V
L
M
A
A
G
G
I
E
G
N
A
E
M
R
E
Q
A
G
T
P
G
K
A
I
W
S
M
G
P
F
G
A
N
T
G
-
D
A
I
S
A
G
I
A
V
G
G
A
T
A
L
L
D
Q
A
W
F
C
--
P
G
V
E
Q
P
D
G
S
A
A
-
F
M
V
-
G
V
R
G
G
L
V
V
D
S
A
G
E
R
Y
L
N
E
-
S
L
P
Y
D
Q
F
------
G
R
A
M
D
A
H
DDNG
S
A
V
---
P
S
F
M
I
F
D
SREGG
G
L
P
A
I
C
I
P
N
T
A
P
A
K
H
-------
L
E
A
G
T
-------
W
V
----
G
A
D
T
-------
L
E
E
L
---
A
A
K
T
G
L
P
-----
A
D
---
A
L
R
S
T
-----
V
E
K
---
F
-----
N
D
A
A
K
L
G
V
D
E
E
F
H
R
G
E
D
P
Y
D
A
F
F
C
P
P
-----
N
G
G
A
N
A
A
L
T
A
I
E
N
-
G
P
F
Y
A
A
--
R
I
V
L
S
D
L
G
-------
T
K
G
G
L
V
T
D
--
V
N
G
R
V
L
R
A
D
G
S
A
I
D
G
L
Y
A
--
A
G
N
T
S
A
S
L
S
G
R
F
Y
-----
P
--
G
P
G
-------------------------
V
P
L
G
T
A
--
M
V
F
S
Y
R
A
A
Q
D
M
A
K
-------------------------
20
Fugue
75.97
21%
-30
- C3 -
4ZOX
-
SQT1_YEAST
A:
[3-381]
------------------------------------------------
M
S
N
N
S
L
T
Y
F
D
K
H
T
D
S
V
F
A
I
G
H
H
P
N
L
P
L
V
C
T
G
G
G
D
N
L
A
H
L
W
T
S
H
S
----------
Q
P
P
K
F
A
G
-----------------------------
T
L
T
G
Y
G
E
S
V
I
S
C
S
F
---
T
S
E
G
G
F
L
V
T
A
D
M
SG
K
V
L
V
H
M
G
Q
K
G
G
A
--
Q
W
K
L
A
S
Q
-------
M
Q
E
V
E
E
--------------
I
V
W
-
L
K
--
T
H
P
T
I
-------
A
R
-
T
F
A
---------
F
G
A
T
D
G
S
V
W
C
Y
Q
I
N
E
Q
---------------
D
G
S
--
L
---
E
Q
L
M
S
G
F
---------------
V
H
Q
Q
D
C
S
M
G
E
F
I
N
T
D
K
G
E
N
T
L
----------
E
L
V
T
C
S
L
-
D
-------------
S
T
I
V
A
W
N
C
--
F
-
T
G
Q
Q
L
F
K
I
T
-
Q
A
E
-
I
K
G
L
E
A
P
W
I
S
L
S
L
A
P
E
T
L
-
T
K
G
N
S
G
V
------
V
A
C
G
S
N
------------
N
G
L
L
-------
A
V
I
N
C
N
N
G
G
--
A
I
L
H
-------
L
S
T
V
I
E
L
K
P
E
Q
D
E
L
----
D
A
-
S
I
E
S
I
S
W
S
S
K
F
S
---
L
M
A
I
G
L
V
C
G
E
I
L
L
Y
---
D
T
S
A
W
-----
R
V
R
H
K
F
V
-----
L
E
D
S
V
T
K
L
M
F
D
---
N
D
D
L
F
A
S
C
I
N
G
K
V
---
Y
Q
F
N
-----------------------
A
R
T
G
--------------------------
Q
E
K
F
V
C
V
-----
G
H
-
N
M
G
V
L
D
F
I
L
L
H
P
--
V
--
A
N
T
G
------
T
E
Q
K
------------
R
K
V
I
T
A
G
D
EG
V
S
L
V
F
E
V
P
N
-----------------------------
19
Fugue
74.00
14%
-40
* C2 *
4XVK
4
DPOLN_HUMAN
A:
[1-666]
KKHFCDIRHLD
D
W
A
K
S
Q
L
I
E
M
L
K
Q
AA
A
L
V
I
T
V
M
Y
TDGSTQLG
A
D
Q
T
P
V
S
S
V
R
G
I
V
V
L
V
K
R
Q
A
C
G
P
V
L
E
G
F
V
S
D
D
P
C
I
Y
I
Q
I
E
H
S
A
I
W
D
Q
E
Q
E
A
H
Q
Q
F
A
R
N
V
L
F
Q
T
M
K
C
K
C
P
V
I
C
F
N
A
K
D
F
V
R
I
V
L
Q
F
F
GNDGSWKHV
A
D
F
I
G
L
D
P
R
I
A
A
W
L
I
---
D
P
S
D
A
T
P
--
S
F
E
--
D
L
V
E
K
Y
C
E
K
S
I
T
--
V
K
V
N
S
T
Y
-------
G
N
S
S
R
N
I
V
N
Q
N
V
--
R
E
N
L
K
T
L
Y
R
-
L
T
--
M
D
L
C
S
K
L
K
D
Y
GL
W
Q
-
L
F
R
TLELPL
I
P
I
L
A
V
M
E
S
H
A
I
Q
V
N
K
E
E
M
E
K
T
S
A
L
L
G
A
R
L
K
E
L
E
Q
E
A
H
F
V
A
GE
R
F
L
I
T
S
N
N
Q
L
R
E
I
L
F
G
K
L
K
-
L
H
L
L
S
Y
P
S
T
S
E
A
V
L
N
A
L
R
D
L
H
P
L
P
K
I
I
L
E
Y
R
Q
V
H
K
I
K
S
T
F
V
D
G
L
L
A
C
M
-----
K
K
G
S
I
---------------
S
S
T
-
W
N
Q
-
T
G
T
V
T
G
R
L
S
A
K
H
P
N
I
Q
G
I
-
S
K
H
P
I
Q
I
T
T
P
KK
I
L
T
I
S
P
R
-----
A
M
F
V
S
S
K
G
H
T
F
-------
L
A
A
D
F
S
Q
I
E
L
R
I
L
T
H
-------
L
S
G
D
P
E
L
L
K
L
D
D
V
F
----
S
-
T
L
T
S
Q
W
K
D
V
P
V
E
Q
---
V
T
H
A
D
R
E
Q
T
K
K
V
V
Y
---
A
V
V
Y
G
AG
K
E
R
L
A
A
C
L
G
V
-----
P
I
Q
E
A
A
Q
F
L
E
S
F
L
Q
K
Y
K
K
I
K
D
F
A
R
A
A
I
---
A
Q
C
H
Q
T
G
C
V
V
S
I
M
G
-
R
R
R
P
L
P
R
I
H
--------------------
A
H
--
D
Q
Q
L
R
A
Q
A
E
R
Q
A
V
N
F
V
V
Q
G
S
A
A
D
L
C
K
L
A
M
I
H
V
F
T
A
V
--
A
--
A
S
H
T
LTARLV
A
Q
I
H
D
E
L
L
F
E
V
E
-
D
P
Q
I
P
E
C
A
A
L
V
--
R
R
T
M
E
S
L
E
Q
V
Q
A
L
E
L
Q
L
Q
V
P
L
K
V
S
L
S
A
GRSWGHLVPLQ
17
Fugue
73.48
20%
-41
* C3 *
4CP6
-
?
A:
[13-417]
------------------------------------------------------------------------------
T
K
V
G
S
I
I
Q
Q
N
N
I
K
Y
K
V
L
T
V
E
G
N
I
G
T
V
Q
V
G
N
G
V
T
P
V
E
F
E
---------------------
A
G
Q
D
G
K
P
F
T
I
P
T
K
I
T
---
V
G
D
K
V
F
T
V
T
E
V
A
--
S
Q
----------------------------------
A
F
S
Y
Y
P
D
E
T
G
R
I
V
Y
Y
P
S
S
--
I
T
I
P
S
S
I
K
K
I
--
Q
K
K
G
F
H
---------
G
S
K
A
K
----
T
I
I
F
D
K
G
S
Q
L
E
---
K
I
E
D
R
-
A
F
D
F
S
E
L
E
---
E
I
E
L
P
A
-
S
L
E
Y
I
G
T
S
A
F
S
F
S
Q
K
L
K
K
L
T
F
S
S
S
S
K
L
E
L
I
S
H
E
---
A
F
A
N
L
S
N
L
E
K
L
T
L
P
K
S
V
-
K
T
L
G
S
N
L
-----
F
R
L
T
--------
T
S
L
K
H
V
D
V
------
E
-
E
G
N
E
S
F
A
S
V
--
D
G
V
L
F
S
K
-
D
--
K
T
Q
L
------
I
Y
Y
P
S
Q
-----
K
N
D
---
E
S
Y
K
T
-------
P
K
E
T
K
--------
E
L
-------
A
S
Y
S
F
N
K
N
S
Y
L
K
K
L
E
L
N
E
G
L
E
K
I
G
T
F
A
F
A
D
A
I
K
---
L
E
E
I
S
L
P
----------
N
S
L
E
T
-----
I
E
R
--
L
A
-----
F
Y
G
N
L
E
L
K
E
L
I
L
P
D
N
V
K
N
F
G
---------------
K
H
V
M
N
G
L
P
K
L
K
S
L
T
I
G
N
N
I
N
S
L
P
S
F
------------
F
L
S
G
VL
D
S
L
K
E
I
H
I
K
N
K
S
T
E
F
S
V
K
--
K
D
T
F
A
I
P
E
T
V
K
F
Y
V
------------------------
T
S
E
H
I
K
D
V
L
K
S
N
L
S
T
S
N
--
D
I
I
V
E
K
V
-------------------------------
10
HHSearch
70.70
23%
-55
- C5 -
3GIU
5
PCP_STAAC
A:
[4-204]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
---
H
I
L
V
T
G
F
A
P
F
D
N
Q
-----------
N
I
N
P
S
W
E
A
V
T
Q
L
E
D
I
I
G
----
T
--
H
T
I
D
K
L
K
L
P
T
S
F
-
K
K
V
D
N
-
I
-----
I
N
----
K
T
L
A
--
S
--
N
H
Y
D
V
V
L
A
-
I
G
Q
A
G
G
R
N
A
I
T
P
E
R
V
A
I
N
I
D
D
A
R
I
P
D
N
D
D
F
------
Q
P
I
D
Q
-----------------------------------
A
I
H
------------------------------------
L
D
G
A
P
---
A
Y
F
S
N
L
P
V
K
A
M
T
Q
S
---
I
I
----------------------------------------------
N
---
Q
G
L
P
----------------------
G
A
L
S
N
-------
S
A
G
T
F
V
C
N
--
H
T
L
Y
H
L
G
Y
L
Q
D
K
H
Y
P
H
L
R
--
F
G
F
I
H
V
P
Y
I
P
E
Q
V
I
G
K
--
P
D
T
P
S
----------------------
M
P
L
E
K
I
V
A
G
L
--
T
A
A
I
E
A
I
S
N
D
E
D
L
H
L
A
L
G
--------------------
15
HHSearch
68.01
18%
-51
* C5 *
1A2Z
-
PCP_THELN
A:
[2-210]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
K
V
L
I
T
G
F
E
P
F
G
G
D
-----------
S
K
N
P
T
E
Q
I
A
K
Y
F
D
R
K
Q
I
G
---
N
--
A
M
V
Y
G
R
V
L
P
V
S
V
-
K
R
A
T
I
----------
E
L
K
R
Y
L
E
--
E
--
I
K
P
E
I
V
I
N
-
L
G
L
A
P
T
Y
S
N
I
T
V
E
R
I
A
V
N
I
I
D
A
R
I
P
D
N
D
G
Y
------
Q
P
I
D
E
-----------------------------------
K
I
E
------------------------------------
E
D
A
P
L
---
A
Y
M
A
T
L
P
V
R
A
I
T
K
T
---
L
R
----------------------------------------------
D
---
N
G
I
P
----------------------
A
T
I
S
Y
-------
S
A
G
T
Y
L
C
N
--
Y
V
M
F
K
T
L
H
F
S
K
I
E
G
Y
P
L
K
--
A
G
F
I
H
V
P
Y
T
P
D
Q
V
V
N
K
--
F
--
F
L
L
G
-------------
K
N
T
P
--
S
M
C
L
E
A
E
I
K
A
I
--
E
L
A
V
K
V
S
L
D
Y
L
E
K
D
R
D
D
I
--------------------
12
HHSearch
67.64
18%
-44
- C5 -
1X10
-
PCP_PYRFU
A:
[1-206]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
---
K
V
L
V
T
G
F
E
P
F
G
G
E
-----------
K
I
N
P
T
E
R
I
A
K
D
L
D
G
I
K
I
---
G
D
--
A
Q
V
F
G
R
V
L
P
V
V
F
-
G
K
A
K
E
-
V
-----
L
E
K
T
----
L
E
--
E
--
I
K
P
D
I
A
I
H
-
V
G
L
A
P
G
R
S
A
I
S
I
E
R
I
A
V
N
A
I
D
A
R
I
P
D
N
E
G
K
------
K
I
E
D
E
-----------------------------------
P
I
V
------------------------------------
P
G
A
P
T
---
A
Y
F
S
T
L
P
I
K
K
I
M
K
K
---
L
H
----------------------------------------------
E
---
R
G
I
P
----------------------
A
Y
I
S
N
-------
S
A
G
L
Y
L
S
N
--
Y
V
M
Y
L
S
L
H
H
S
A
T
K
G
Y
P
K
M
--
S
G
F
I
H
V
P
Y
I
P
E
Q
I
I
D
K
--
I
G
K
G
Q
----------------
V
P
P
S
--
M
S
Y
E
M
A
L
E
A
V
--
K
V
A
I
E
V
A
L
E
E
L
L
--------------------------
9
HHSearch
66.28
19%
-45
- C5 -
3RO0
1
PCP_BACAM
A:
[2-206]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
---
K
V
L
L
T
G
F
D
P
F
G
G
E
-----------
T
V
N
P
S
W
E
A
V
K
R
L
N
G
A
A
E
---
G
P
--
A
S
I
V
S
E
Q
V
P
T
V
F
-
Y
K
S
L
A
----------
V
L
R
E
A
M
K
--
K
--
H
Q
P
D
I
I
I
C
-
V
G
Q
A
G
G
R
M
Q
I
T
P
E
R
V
A
I
N
L
N
E
A
R
I
P
D
N
E
G
N
------
Q
P
V
G
E
-----------------------------------
D
I
S
------------------------------------
Q
G
G
P
A
---
A
Y
W
T
G
L
P
I
K
R
I
V
E
E
---
I
K
----------------------------------------------
K
---
E
G
I
P
----------------------
A
A
V
S
Y
-------
T
A
G
T
F
V
C
N
--
H
L
F
Y
G
L
M
D
E
I
S
R
H
H
P
H
I
R
--
G
G
F
I
H
I
P
Y
I
P
E
Q
T
L
Q
K
--
S
---------------------
A
P
S
--
L
S
L
D
H
I
T
K
A
L
--
K
I
A
A
V
T
A
A
A
H
E
D
D
I
E
-----------------------
14
HHSearch
64.72
17%
-51
- C5 -
3LAC
3
PCP_BACAN
A:
[2-202]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
---
T
V
L
L
T
G
F
D
P
F
G
G
E
-----------
S
I
N
P
A
W
E
V
A
K
S
L
H
E
K
T
I
G
---
E
--
Y
K
I
I
S
K
Q
V
P
T
V
F
-
H
K
S
I
S
-
V
-----
L
K
E
Y
----
I
E
--
E
--
L
A
P
E
F
I
I
C
-
I
G
Q
A
G
G
R
P
D
I
T
I
E
R
V
A
I
N
I
D
D
A
R
I
A
D
N
E
G
N
------
Q
P
V
D
V
-----------------------------------
P
V
V
------------------------------------
E
E
G
P
A
---
A
Y
W
S
T
L
P
M
K
A
I
V
K
K
---
L
Q
----------------------------------------------
E
---
E
G
I
P
----------------------
A
S
V
S
Q
-------
T
A
G
T
F
V
C
N
--
H
L
F
Y
G
L
M
H
E
L
E
K
H
D
T
K
M
K
--
G
G
F
I
H
I
P
F
L
P
E
Q
A
S
N
Y
P
G
Q
--
P
S
----------------------
M
S
L
S
T
I
R
K
G
I
--
E
L
A
V
E
V
T
T
T
V
E
---------------------------
11
HHSearch
64.32
20%
-50
- C5 -
1IU8
-
PCP_PYRHO
A:
[1-202]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
---
K
I
L
L
T
G
F
E
P
F
G
G
D
-----------
D
K
N
P
T
M
D
I
V
E
A
L
S
E
R
I
--------
P
E
V
V
G
E
I
L
P
V
S
F
-
K
R
A
R
E
----------
K
L
L
K
V
L
D
--
D
--
V
R
P
D
I
T
I
N
-
L
G
L
A
P
G
R
T
H
I
S
V
E
R
V
A
V
N
M
I
D
A
R
I
P
D
N
D
G
E
------
Q
P
K
D
E
-----------------------------------
P
I
V
------------------------------------
E
G
G
P
A
---
A
Y
F
A
T
I
P
T
R
E
I
V
E
E
---
M
K
----------------------------------------------
K
---
N
G
I
P
----------------------
A
V
L
S
Y
-------
T
A
G
T
Y
L
C
N
--
F
A
M
Y
L
T
L
H
T
S
A
T
K
G
Y
P
K
I
--
A
G
F
I
H
V
P
Y
T
P
D
Q
V
L
E
K
--
K
--
N
T
--------------------
P
S
M
S
L
D
L
E
I
K
G
V
--
E
I
A
I
R
V
A
Q
S
A
L
H
S
S
Q
L
R
---------------------
13
HHSearch
59.52
21%
-53
- C5 -
2EBJ
-
?
A:
[1-191]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
I
L
V
T
G
F
E
P
F
G
S
L
-----------
E
H
N
P
S
Q
A
L
L
D
L
L
P
S
E
V
D
----
G
--
K
P
L
R
K
A
V
L
P
V
D
A
-
E
A
L
G
E
-
A
-----
L
E
D
----
L
H
---
R
--
E
G
P
K
A
V
L
H
-
L
G
L
A
E
D
R
P
V
L
T
L
E
R
L
A
V
N
L
L
D
F
P
R
P
D
N
R
G
R
------
V
L
E
D
L
-----------------------------------
P
I
V
------------------------------------
P
G
G
P
L
---
A
L
P
A
R
F
P
V
K
P
V
L
A
R
---
W
R
----------------------------------------------
E
---
A
G
I
P
----------------------
G
R
P
S
L
-------
S
A
G
S
Y
L
C
N
--
Q
A
F
Y
L
S
L
Y
R
L
P
E
---
E
V
P
--
V
G
F
L
H
L
P
P
D
E
T
L
A
L
K
R
P-
R
--
P
Y
----------------------
V
P
L
E
V
Q
A
R
A
V
--
R
L
A
L
E
H
L
-------------------------------
16
Fugue
49.89
15%
3
- C5 -
1AUG
-
PCP_BACAM
A:
[1-210]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
---
E
K
K
V
L
-------
L
T
G
F
D
P
F
G
G
E
T
V
N
P
S
-------
W
E
A
V
K
R
L
N
G
A
A
E
--------
G
P
A
S
I
V
S
E
Q
V
P
T
V
---
F
Y
K
S
L
A
V
L
R
E
A
I
K
K
H
QP
D
I
I
I
C
-----
V
G
Q
A
G
G
R
-----
M
Q
I
T
P
E
--
R
V
A
I
N
L
N
E
A
R
I
P
D
N
E
G
N
Q
P
---
V
G
E
D
I
S
Q
G
G
P
A
A
Y
W
-
T
G
L
P
I
K
R
I
V
E
E
I
K
K
E
G
I
P
A
A
V
S
Y
T
A
G
T
F
V
C
N
--
H
L
F
Y
G
L
M
D
E
I
S
R
H
H
P
H
I
R
--
G
G
F
I
H
I
P
Y
I
P
E
Q
T
L
Q
K
---------------------
S
A
P
S
L
S
L
D
H
I
T
K
A
L
K
I
A
A
--
V
T
A
A
V
H
E
----
D
D
I
E
T
G
---------------------
2
PsiBlast_PDB
46.32
24%
-31
* C4 *
1TG7
4
BGALA_PENSQ
A:
[79-240]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
F
F
D
A
A
-----
K
E
A
G
I
Y
L
L
A
R
--
P
G
P
Y
-
I
N
A
E
V
S
-----
G
G
G
F
P
G
W
L
Q
R
V
D
G
I
L
R
T
S
-----
D
E
A
------
Y
L
K
A
T
D
-----
N
Y
A
---
S
N
I
A
A
-------
T
I
A
K
A
Q
I
T
N
G
G
P
I
I
L
Y
Q
P
E
NEY
S
G
A
C
C
G
Y
N
----------
G
F
P
D
G
S
-
Y
M
Q
Y
I
E
D
H
---
A
R
D
A
G
I
V
V
-
P
F
I
S
N
---
D
A
W
A
A
-----
G
H
N
A
P
G
T
-----
G
A
G
A
V
---
D
I
Y
G
H
D
S
Y
P
L
G
F
D
C
A
N
P
S
T
WPS
G
N
L
P
T
Y
F
H
T
S
H
E
Q
Q
-
S
P
S
T
P
Y
S
L
V
E
F
Q
G
G
A
F
-------
D
P
W
G
G
V
G
F
--
A
K
C
A
A
L
L
N
H
E
F
E
R
V
F
Y
K
N
--
D
F
S
F
G
V
A
F
L
N
L
Y
M
I
F
G
--
G
--
T
N
W
G
------
N
L
G
H
P
G
G
Y
T
S
Y
D
Y
G
S
A
I
S
E
S
R
N
I
T
--
R
E
K
Y
S
E
L
K
L
L
G
N
F
A
K
V
S
P
--------------------
3
PsiBlast_PDB
46.11
24%
-33
- C4 -
1XC6
8
BGALA_PENSQ
A:
[79-240]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
F
F
D
A
A
-----
K
E
A
G
I
Y
L
L
A
R
--
P
G
P
Y
-
I
N
A
E
V
S
-----
G
G
G
F
P
G
W
L
Q
R
V
D
G
I
L
R
T
S
-----
D
E
A
------
Y
L
K
A
T
D
-----
N
Y
A
---
S
N
I
A
A
-------
T
I
A
K
A
Q
I
T
N
G
G
P
I
I
L
Y
Q
P
E
NEY
S
G
A
C
C
G
Y
N
----------
G
F
P
D
G
S
-
Y
M
Q
Y
I
E
D
H
---
A
R
D
A
G
I
V
V
-
P
F
I
S
N
---
D
A
W
A
A
-----
G
H
N
A
P
G
T
-----
G
A
G
A
V
---
D
I
Y
G
H
D
S
Y
P
L
G
F
D
C
A
N
P
S
T
WPS
G
N
L
P
T
Y
F
H
T
S
H
E
Q
Q
-
S
P
S
T
P
Y
S
L
V
E
F
Q
G
G
A
F
-------
D
P
W
G
G
V
G
F
--
A
K
C
A
A
L
L
N
H
E
F
E
R
V
F
Y
K
N
--
D
F
S
F
G
V
A
F
L
N
L
Y
M
I
F
G
--
G
--
T
N
W
G
------
N
L
G
H
P
G
G
Y
T
S
Y
D
Y
G
S
A
I
S
E
S
R
N
I
T
--
R
E
K
Y
S
E
L
K
L
L
G
N
F
A
K
V
S
P
--------------------
4
PsiBlast_PDB
42.69
27%
-26
- C1 -
4KVN
2
?
H:
[35-126]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
V
R
--
Q
A
P
G
K
G
L
E
W
V
T
L
I
S
Y
-
D
G
A
N
Q
Y
Y
A
D
S
V
K
G
R
F
T
I
S
-
R
D
N
S
K
N
T
------
V
Y
L
Q
M
N
-----
S
L
R
---
P
E
----------------
D
T
A
V
Y
Y
C
A
V
-------
P
G
P
V
F
G
I
F
P
P
--
W
S
----
Y
F
D
N
---
W
G
Q
G
I
L
V
T
---
V
S
S
A
S
T
K
G
P
S
V
F
P
L
---
A
P
S
S
T
-----
A
A
L
G
C
L
V
-----
K
D
Y
F
P
E
P
V
T
V
S
W
N
S
G
A
L
T
S
G
V
H
T
F
P
A
V
---
L
Q
S
S
G
L
Y
S
L
S
S
V
V
T
-
V
P
S
S
S
L
G
T
Q
T
Y
I
C
N
V
N
-------
H
K
P
S
N
T
K
V
--
D
K
K
V
E
P
K
------------------------------------------------------------------------------------------------------------
1
PsiBlast_PDB
40.12
35%
-44
- C1 -
4HEM
-
?
E:
[36-88]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
F
R
QA
P
--
E
R
-
E
F
V
A
T
-
I
S
Q
-
T
G
S
H
T
Y
Y
R
N
S
V
K
G
R
F
T
I
S
-
R
D
N
A
K
N
T
------
V
Y
L
Q
M
N
-----
N
M
K
---
P
E
D
T
A
-------
V
Y
Y
C
A
A
G
D
N
Y
Y
Y
T
R
T
-------
Y
E
Y
D
Y
W
G
Q
G
T
Q
V
T
V
----
S
S
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_CBE
31.84
33%
0
* C1 *
4P68
3
?
A:
[12-79]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
I
----
G
M
E
N
A
M
P
W
--
N
L
P
A
D
L
A
W
F
K
R
N
T
L
N
K
P
V
I
M
G
R
---
H
T
W
E
S
-----
I
G
R
P
P
G
R
K
N
I
I
L
S
S
Q
P
G
T
D
D
R
V
T
W
V
K
S
V
D
E
A
I
A
A
A
G
D
V
P
---
E
I
M
V
I
G
G
G
R
V
Y
E
Q
F
-
L
P
K
A
Q
K
L
Y
L
T
H
I
D
A
E
V
-------
E
G
D
T
H
F
P
D
--
Y
E
P
D
D
W
E
S
V
F
S
E
F
H
D
A
D
A
--
Q
N
S
H
S
Y
S
F
E
I
L
E
R
R
---------------------------------------------------------------------------------
7
PsiBlast_PDB
1.37
46%
139
- C4 -
2QNO
1
GUNF_CLOCE
A:
[51-78]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
-
T
S
Q
-
A
M
S
Y
Y
M
W
L
E
A
M
H
G
R
F
S
G
D
-
F
T
G
F
D
K
S
------
W
S
V
T
E
Q
-----
Y
L
I
---
P
T
E
K
D
-------
Q
P
N
T
S
M
S
R
Y
D
A
N
K
P
A
-------
T
Y
A
P
E
F
Q
D
P
S
K
Y
P
S
----
P
L
D
T
S
Q
P
V
G
R
D
P
I
N
S
---
Q
L
T
S
A
Y
G
T
S
M
L
Y
G
M
---
H
W
I
L
D
-----
V
D
N
W
Y
G
F
-----
G
A
R
A
D
G
T
S
K
P
S
Y
I
N
T
F
Q
R
G
E
Q
E
S
T
W
E
T
---
I
P
Q
P
C
W
D
E
H
K
F
G
G
Q
-
Y
G
F
L
D
L
F
T
K
D
T
G
T
P
A
K
-------
Q
F
K
Y
T
N
A
P
--
D
A
D
A
R
A
V
Q
A
T
Y
W
A
D
Q
W
A
K
--
E
Q
G
K
S
V
S
T
S
V
G
K
A
T
K
M
--
G
--
D
Y
L
R
------
Y
S
F
F
D
K
Y
F
R
K
I
G
Q
P
S
Q
A
G
T
G
Y
D
A
A
--
H
Y
L
L
S
W
Y
Y
A
W
G
G
G
I
D
S
T
W
--------------------
6
PsiBlast_PDB
0.83
46%
144
- C4 -
1FBW
1
GUNF_CLOCE
A:
[51-78]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
-
T
S
Q
-
A
M
S
Y
Y
M
W
L
E
A
M
H
G
R
F
S
G
D
-
F
T
G
F
D
K
S
------
W
S
V
T
E
Q
-----
Y
L
I
---
P
T
E
K
D
-------
Q
P
N
T
S
M
S
R
Y
D
A
N
K
P
A
-------
T
Y
A
P
E
F
Q
D
P
S
K
Y
P
S
----
P
L
D
T
S
Q
P
V
G
R
D
P
I
N
S
---
Q
L
T
S
A
Y
G
T
S
M
L
Y
G
M
---
H
W
I
L
D
-----
V
D
N
W
Y
G
F
-----
G
A
R
A
D
G
T
S
K
P
S
Y
I
N
T
F
Q
R
G
E
Q
E
S
T
W
E
T
---
I
P
Q
P
C
W
D
E
H
K
F
G
G
Q
-
Y
G
F
L
D
L
F
T
K
D
T
G
T
P
A
K
-------
Q
F
K
Y
T
N
A
P
--
D
A
D
A
R
A
V
Q
A
T
Y
W
A
D
Q
W
A
K
--
E
Q
G
K
S
V
S
T
S
V
G
K
A
T
K
M
--
G
--
D
Y
L
R
------
Y
S
F
F
D
K
Y
F
R
K
I
G
Q
P
S
Q
A
G
T
G
Y
D
A
A
--
H
Y
L
L
S
W
Y
Y
A
W
G
G
G
I
D
S
T
W
--------------------
5
PsiBlast_PDB
0.11
46%
143
- C4 -
1F9D
1
GUNF_CLOCE
A:
[51-78]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
T
-
T
S
Q
-
A
M
S
Y
Y
M
W
L
E
A
M
H
G
R
F
S
G
D
-
F
T
G
F
D
K
S
------
W
S
V
T
E
Q
-----
Y
L
I
---
P
T
E
K
D
-------
Q
P
N
T
S
M
S
R
Y
D
A
N
K
P
A
-------
T
Y
A
P
E
F
Q
D
P
S
K
Y
P
S
----
P
L
D
T
S
Q
P
V
G
R
D
P
I
N
S
---
Q
L
T
S
A
Y
G
T
S
M
L
Y
G
M
---
H
W
I
L
D
-----
V
D
N
W
Y
G
F
-----
G
A
R
A
D
G
T
S
K
P
S
Y
I
N
T
F
Q
R
G
E
Q
E
S
T
W
E
T
---
I
P
Q
P
C
W
D
E
H
K
F
G
G
Q
-
Y
G
F
L
D
L
F
T
K
D
T
G
T
P
A
K
-------
Q
F
K
Y
T
N
A
P
--
D
A
D
A
R
A
V
Q
A
T
Y
W
A
D
Q
W
A
K
--
E
Q
G
K
S
V
S
T
S
V
G
K
A
T
K
M
--
G
--
D
Y
L
R
------
Y
S
F
F
D
K
Y
F
R
K
I
G
Q
P
S
Q
A
G
T
G
Y
D
A
A
--
H
Y
L
L
S
W
Y
Y
A
W
G
G
G
I
D
S
T
W
--------------------