@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0065: (2015-12-20 )
MRDAALRYPNILFDLDGTLTDPREGITRSVQFALARLGIDEPDLARLEHFIGPPLLQCFMQTYGFDEARAWEAVNHYRERFRVTGLYENRVFDGIPELLEALVGRGHTLYVATSKPGVFAREIARHFAFDRHFKAIYGSELDGTRTHKEELIRHLLDSEGLAAEHCLMIGDRMHDLLGASRNGVACIGVGYGFGSEDELRAHQPTHYCADLAALRQVLESH
Atome Classification :
(20 SA)
.........10........20........30.....-..-.40--.--.......50.--.-----------.---...----.----.---60---------..--...-----.----.----..70........80--.-----..-...--..-----90------.------------------........100.---..-....110........120.......130.-......140.......------150.......---160--------.-.......170.-......180.......190.......-200.......210..-.....220
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MRDAALRYP
N
I
L
F
DLDGTLTD
P
R
E
G
I
T
R
S
V
Q
F
A
L
A
R-LG-ID
E
--
P
--
D
L
A
R
L
E
H
FIG--
P
-----------
P
---
L
L
Q
----
C
----
F
---
M
----------
Q
T--YGF-----
D
----
E
----
A
R
A
W
E
A
V
N
H
Y
R
E
R
F
--R-----VT-GLY--EN-----
R
-------
V
------------------
F
D
G
I
P
E
L
L
E
A
L
V---GR-G
H
T
L
Y
-
V
ATSKP
G
V
F
A
R
E
I
A
R
H
F
A
F
D
R
H
F
-
K
A
I
YGSELDGTR
T
H
K
E
------
E
L
I
R
H
L
LDSE---GL---------
A
-
A
E
H
C
L
M
I
G
D
R
M
-
H
D
L
LGASRN
G
V
A
C
I
G
V
GYGFGSEDEL-RAHQP
T
H
Y
C
A
D
L
A
A
L
-
R
Q
V
L
ESH
1
PsiBlast_PDB
88.79
46%
-128
- C1 -
3SD7
5
?
A:
[28-239]
------
N
Y
E
I
V
L
F
D
L
D
G
T
L
T
D
P
K
E
G
I
T
K
S
I
Q
Y
S
L
N
S
-
F
G
-
I
K
E
-----
D
L
E
N
L
D
Q
F
I
G
--
P
-----------
P
---
L
H
D
----
T
----
F
---
K
----------
E
Y
--
Y
K
F
-----
E
----
D
----
K
K
A
K
E
A
V
E
K
Y
R
E
Y
F
--
A
-----
D
K
-
G
I
F
--
E
N
-----
K
-------
I
------------------
Y
E
N
M
K
E
I
L
E
M
L
Y
---
K
N
-
G
K
I
L
L
-
V
A
T
S
K
P
T
V
F
A
E
T
I
L
R
Y
F
D
I
D
R
Y
F
-
K
Y
I
A
G
S
N
L
D
G
T
R
V
N
K
N
------
E
V
I
Q
Y
V
L
D
L
C
---
N
V
---------
K
D
K
D
K
V
I
M
V
G
D
R
K
-
Y
D
I
I
G
A
K
K
I
G
I
D
S
I
G
V
L
Y
G
Y
G
S
F
E
E
I
-
S
E
S
E
P
T
Y
I
V
E
N
V
E
S
I
-
K
D
I
L
L
--
31
HHSearch
88.16
46%
-128
- C1 -
3SD7
5
?
A:
[26-239]
----
K
K
N
Y
E
I
V
L
F
D
L
D
G
T
L
T
D
P
K
E
G
I
T
K
S
I
Q
Y
S
L
N
S
-
F
G
-
I
K
E
--
D
---
L
E
N
L
D
Q
F
I
G
--
P
-----------
P
---
L
H
D
----
T
----
F
---
K
----------
E
Y
--
Y
K
F
-----
E
----
D
----
K
K
A
K
E
A
V
E
K
Y
R
E
Y
F
--
A
-----
D
K
-
G
I
F
--
E
N
-----
K
-------
I
------------------
Y
E
N
M
K
E
I
L
E
M
L
Y
---
K
N
-
G
K
I
L
L
-
V
A
T
S
K
P
T
V
F
A
E
T
I
L
R
Y
F
D
I
D
R
Y
F
-
K
Y
I
A
G
S
N
L
D
G
T
R
V
N
K
N
------
E
V
I
Q
Y
V
L
D
L
C
---
N
V
K--------
D
-
K
D
K
V
I
M
V
G
D
R
K
-
Y
D
I
I
G
A
K
K
I
G
I
D
S
I
G
V
L
Y
G
Y
G
S
F
E
E
I
-
S
E
S
E
P
T
Y
I
V
E
N
V
E
S
I
-
K
D
I
L
L
--
28
HHSearch
85.90
44%
-118
- C1 -
3MC1
3
?
A:
[2-216]
-----
S
L
Y
N
Y
V
L
F
D
L
D
G
T
L
T
D
S
A
E
G
I
T
K
S
V
K
Y
S
L
N
K
-
F
D
-
I
Q
V
--
E
--
D
L
S
S
L
N
K
F
V
G
--
P
-----------
P
---
L
K
T
----
S
----
F
---
M
----------
E
Y
--
Y
N
F
-----
D
----
E
----
E
T
A
T
V
A
I
D
Y
Y
R
D
Y
F
--
K
-----
A
K
-
G
M
F
--
E
N
-----
K
-------
V
------------------
Y
D
G
I
E
A
L
L
S
S
L
K
---
D
Y
-
G
F
H
L
V
-
V
A
T
S
K
P
T
V
F
S
K
Q
I
L
E
H
F
K
L
A
F
Y
F
-
D
A
I
V
G
S
S
L
D
G
K
L
S
T
K
E
------
D
V
I
R
Y
A
M
E
S
L
---
N
I
---------
K
-
S
D
D
A
I
M
I
G
D
R
E
-
Y
D
V
I
G
A
L
K
N
N
L
P
S
I
G
V
T
Y
G
F
G
S
Y
E
E
L
-
K
N
A
G
A
N
Y
I
V
N
S
V
D
E
L
-
H
K
K
I
L
E
L
2
PsiBlast_PDB
83.59
44%
-117
- C1 -
3MC1
3
?
A:
[4-216]
-------
Y
N
Y
V
L
F
D
L
D
G
T
L
T
D
S
A
E
G
I
T
K
S
V
K
Y
S
L
N
K
-
F
D
-
I
Q
V
--
E
--
D
L
S
S
L
N
K
F
V
G
--
P
-----------
P
---
L
K
T
----
S
----
F
---
M
----------
E
Y
--
Y
N
F
-----
D
----
E
----
E
T
A
T
V
A
I
D
Y
Y
R
D
Y
F
--
K
-----
A
K
-
G
M
F
--
E
N
-----
K
-------
V
------------------
Y
D
G
I
E
A
L
L
S
S
L
K
---
D
Y
-
G
F
H
L
V
-
V
A
T
S
K
P
T
V
F
S
K
Q
I
L
E
H
F
K
L
A
F
Y
F
-
D
A
I
V
G
S
S
L
D
G
K
L
S
T
K
E
------
D
V
I
R
Y
A
M
E
S
L
---
N
I
---------
K
-
S
D
D
A
I
M
I
G
D
R
E
-
Y
D
V
I
G
A
L
K
N
N
L
P
S
I
G
V
T
Y
G
F
G
S
Y
E
E
L
-
K
N
A
G
A
N
Y
I
V
N
S
V
D
E
L
H
K
K
I
L
E
L
-
4
PsiBlast_PDB
70.72
30%
-101
- C1 -
4EX6
2
?
A:
[21-235]
---------
G
V
I
L
D
L
D
G
T
L
A
D
T
P
A
A
I
A
T
I
T
A
E
V
L
A
A
-
M
G
-
T
A
V
--
S
--
R
G
A
I
L
S
T
-
V
G
--
R
-----------
P
---
L
P
A
----
S
----
L
---
A
----------
G
L
--
L
G
V
PV---
E
----
D
----
P
R
V
A
E
A
T
E
E
Y
G
R
R
F
G
A
H
-----
V
R
-
A
A
G
--
P
R
-----
L
-------
L
------------------
Y
P
G
V
L
E
G
L
D
R
L
S
---
A
A
-
G
F
R
L
A
-
M
A
T
S
K
V
E
K
A
A
R
A
I
A
E
L
T
G
L
D
T
R
L
-
T
V
I
A
G
D
D
S
V
E
R
G
K
P
H
P
------
D
M
A
L
H
V
A
R
G
L
---
G
I
---------
P
-
P
E
R
C
V
V
I
G
D
G
V
-
P
D
A
E
M
G
R
A
A
G
M
T
V
I
G
V
S
Y
G
V
S
G
P
D
E
L
M
R
A
G
A
D
T
V
V
D
S
F
P
A
A
V
-
T
A
V
L
D
G
-
5
PsiBlast_PDB
70.47
30%
-106
- C1 -
4EX7
3
?
A:
[21-235]
---------
G
V
I
L
D
L
D
G
T
L
A
D
T
P
A
A
I
A
T
I
T
A
E
V
L
A
A
-
M
G
-
T
A
V
--
S
--
R
G
A
I
L
S
T
-
V
G
--
R
-----------
P
---
L
P
A
----
S
----
L
---
A
----------
G
L
--
L
G
V
PV---
E
----
D
----
P
R
V
A
E
A
T
E
E
Y
G
R
R
F
G
A
H
-----
V
R
-
A
A
G
--
P
R
-----
L
-------
L
------------------
Y
P
G
V
L
E
G
L
D
R
L
S
---
A
A
-
G
F
R
L
A
-
M
A
T
S
K
V
E
K
A
A
R
A
I
A
E
L
T
G
L
D
T
R
L
-
T
V
I
A
G
D
D
S
V
E
R
G
K
P
H
P
------
D
M
A
L
H
V
A
R
G
L
---
G
I
---------
P
-
P
E
R
C
V
V
I
G
D
G
V
-
P
D
A
E
M
G
R
A
A
G
M
T
V
I
G
V
S
Y
G
V
S
G
P
D
E
L
M
R
A
G
A
D
T
V
V
D
S
F
P
A
A
V
-
T
A
V
L
D
G
-
7
PsiBlast_PDB
66.81
24%
-114
- C1 -
2YY6
1
GPH_AQUAE
A:
[4-208]
----------
I
L
F
D
L
D
G
T
L
I
D
S
A
K
D
I
A
L
A
L
E
K
T
L
K
E
-
L
G
-
L
E
E
YY
P
--
D
--
N
V
T
K
Y
I
G
--
G
-----------
G
---
V
-
R
----
A
----
L
---
L
----------
E
K
--
V
L
K
-----
D
----
K
----
F
R
E
-
E
Y
V
E
V
F
R
K
H
Y
--
L
-----
E
N
-
P
V
V
--
Y
T
-----
K
-------
P
------------------
Y
P
E
I
P
Y
T
L
E
A
L
K
---
S
K
-
G
F
K
L
A
-
V
V
S
N
K
L
E
E
L
S
K
K
I
L
D
I
L
N
L
S
G
Y
F
-
D
L
I
V
G
G
D
T
F
G
E
K
K
P
S
P
------
T
P
V
L
K
T
L
E
I
L
---
G
E
---------
E
-
P
E
K
A
L
I
V
G
D
T
D
-
A
D
I
E
A
G
K
R
A
G
T
K
T
A
L
A
L
W
G
Y
V
---
K
L
-
N
S
Q
I
P
D
F
T
L
S
R
P
S
D
L
-
V
K
L
M
D
N
-
29
HHSearch
66.23
20%
-107
- C1 -
2HI0
10
?
A:
[2-238]
-----
M
K
Y
K
A
A
I
F
D
M
D
G
T
I
L
D
T
S
A
D
L
T
S
A
L
N
Y
A
F
E
Q
-
T
G
-
H
R
H
--
D
F-
T
V
E
D
I
K
N
F
F
G
--
S
-----------
G
---
V
V
V
----
A
V
T
R
A
L
---
A
Y
E
A
GSSRESL
V
A
--
F
G
T
KDEQI
P
EAVT
Q
----
T
E
V
N
R
V
L
E
V
F
K
P
Y
Y
--
A
-----
D
H
-
C
Q
I
--
K
T
-----
G
-------
P
------------------
F
P
G
I
L
D
L
M
K
N
L
R
---
Q
K
-
G
V
K
L
A
-
V
V
S
N
K
P
N
E
A
V
Q
V
L
V
E
E
L
F
-
P
G
S
F
-
D
F
A
L
G
E
K
S
G
I
R
R
K
P
A
P
------
D
M
T
S
E
C
V
K
V
L
---
G
V
---------
P
-
R
D
K
C
V
Y
I
G
D
S
E
-
I
D
I
Q
T
A
R
N
S
E
M
D
E
I
A
V
N
W
G
F
R
S
V
P
F
L
-
Q
K
H
G
A
T
V
I
V
D
T
A
E
K
L
-
E
E
A
I
L
G
E
19
PsiBlast_PDB
65.96
22%
-103
- C1 -
2HCF
3
?
A:
[7-227]
----------
V
L
F
D
I
D
G
T
L
L
K
V
E
S
M
N
R
R
V
L
A
D
A
L
I
E
-
V
Y
-
G
T
E
--
G
--
S
T
----
D
F
S
G
--
K
M
D
G
--------
A
---
I
I
Y
----
E
----
V
---
L
----------
S
N
--
V
G
L
-----
E
----
R
----
A
E
I
A
D
K
F
D
K
A
K
E
T
Y
---------
I
-
A
L
F
--
R
E
-----
R
ARRED
I
T
L
------------------
L
E
G
V
R
E
L
L
D
A
L
S
---
S
R
-
S
D
V
L
L
G
L
L
T
G
N
F
E
A
S
G
R
H
K
L
K
L
P
G
I
D
H
Y
F
-
P
--
F
G
A
F
A
D
D
A
L
D
R
N
E
L
P
H
I
A
L
E
R
A
R
R
M
T
G
A
----
N
Y
---------
S
-
P
S
Q
I
V
I
I
G
D
T
E
-
H
D
I
R
C
A
R
E
L
D
A
R
S
I
A
V
A
T
G
N
F
T
M
E
E
L
-
A
R
H
K
P
G
T
L
F
K
N
F
A
E
T
-
D
E
V
L
A
S
I
35
HHSearch
65.74
22%
-108
* C1 *
2HSZ
3
?
A:
[20-243]
----
M
T
Q
F
K
L
I
G
F
D
L
D
G
T
L
V
N
S
L
P
D
L
A
L
S
I
N
S
A
L
K
D
-
V
N
-
L
P
Q
--
A
--
S
E
N
L
V
M
T
W
I
G
--
N
-----------
G
---
A
D
V
L
S
Q
R
A
----
V
D
W
A
C
----------
K
Q
A
E
K
E
L
-----
T
----
E
----
D
E
F
K
Y
F
K
R
Q
F
G
F
Y
Y
--
G
-----
E
N
-
L
C
N
--
I
S
-----
R
-------
L
------------------
Y
P
N
V
K
E
T
L
E
A
L
K
---
A
Q
-
G
Y
I
L
A
-
V
V
T
N
K
P
T
K
H
V
Q
P
I
L
T
A
F
G
I
D
H
L
F
-
S
E
M
L
G
G
Q
S
L
P
E
I
K
P
H
P
------
A
P
F
Y
Y
L
C
G
K
F
---
G
L
---------
Y
-
P
K
Q
I
L
F
V
G
D
S
Q
-
N
D
I
F
A
A
H
S
A
G
C
A
V
V
G
L
T
Y
G
Y
N
Y
N
I
P
I
-
A
Q
S
K
P
D
W
I
F
D
D
F
A
D
I
-
L
K
I
T
Q
--
27
HHSearch
64.71
24%
-105
- C1 -
3D6J
3
?
A:
[5-214]
------
K
Y
T
V
Y
L
F
D
F
D
Y
T
L
A
D
S
S
R
G
I
V
T
C
F
R
S
V
L
E
R
-
H
G
-
Y
T
G
--
I
--
T
D
D
M
I
K
R
T
I
G
--
K
-----------
T
---
L
E
E
----
S
----
F
---
S
----------
I
L
--
T
G
I
-----
T
D---
A
----
D
Q
L
E
S
F
R
Q
E
Y
S
K
E
A
--
D
-----
I
Y
-
M
N
A
--
N
T
-----
I
-------
L
------------------
F
P
D
T
L
P
T
L
T
H
L
K
---
K
Q
-
G
I
R
I
G
-
I
I
S
T
K
Y
R
F
R
I
L
S
F
L
R
N
H
M
P
D
D
W
F
-
D
I
I
I
G
G
E
D
V
T
H
H
K
P
D
P
------
E
G
L
L
L
A
I
D
R
L
---
K
A
---------
C
-
P
E
E
V
L
Y
I
G
D
S
T
-
V
D
A
G
T
A
A
A
A
G
V
S
F
T
G
V
T
S
G
M
T
T
A
Q
E
F
-
Q
A
Y
P
Y
D
R
I
I
S
T
L
G
Q
L
-
I
------
8
PsiBlast_PDB
64.31
24%
-107
- C1 -
2NYV
-
GPH_AQUAE
A:
[6-211]
----------
I
L
F
D
L
D
G
T
L
I
D
S
A
K
D
I
A
L
A
L
E
K
T
L
K
E
-
L
G
-
L
E
E
--
Y
--
Y
P
D
N
V
T
K
Y
I
G
--
G
-----------
G
---
V
-
R
----
A
----
L
---
L
----------
E
K
--
V
L
K
-----
D
----
K
----
F
R
E
-
E
Y
V
E
V
F
R
K
H
Y
--
L
-----
E
N
-
P
V
V
--
Y
T
-----
K
-------
P
------------------
Y
P
E
I
P
Y
T
L
E
A
L
K
---
S
K
-
G
F
K
L
A
-
V
V
S
N
K
L
E
E
L
S
K
K
I
L
D
I
L
N
L
S
G
Y
F
-
D
L
I
V
G
G
D
T
F
G
E
K
K
P
S
P
------
T
P
V
L
K
T
L
E
I
L
---
G
E
---------
E
-
P
E
K
A
L
I
V
G
D
T
D
-
A
D
I
E
A
G
K
R
A
G
T
K
T
A
L
A
L
W
G
Y
V
---
K
L
-
N
S
Q
I
P
D
F
T
L
S
R
P
S
D
L
-
V
K
L
M
D
N
H
46
HHSearch
63.38
23%
-124
- C1 -
3QNM
3
?
A:
[3-233]
-----
L
K
Y
K
N
L
F
F
D
L
D
D
T
I
W
A
F
S
R
N
A
R
D
T
F
E
E
V
Y
Q
K
-
Y
S
-
F
D
R
--
Y
FD
S
F
D
H
Y
Y
T
L
Y
Q
--
R
R
N
T
E
L
W
L
E
Y
G
E
G
KVT
K
E
E
----
L
N
R
Q
R
F
F
Y
P
L
----------
Q
A
--
V
G
V
-----
E
----
D
----
E
---
A
L
A
E
R
F
S
E
D
F
--
F
-----
A
I
-
I
P
T
--
K
S
-----
G
-------
L
------------------
M
P
H
A
K
E
V
L
E
Y
L
A
---
P
--
Q
Y
N
L
Y
-
I
L
S
N
G
F
R
E
L
Q
S
R
K
M
R
S
A
G
V
D
R
Y
F
-
K
K
I
I
L
S
E
D
L
G
V
L
K
P
R
P
------
E
I
F
H
F
A
L
S
A
T
---
Q
S
---------
E
-
L
R
E
S
L
M
I
G
D
S
W
E
A
D
I
T
G
A
H
G
V
G
M
H
Q
A
F
Y
N
V
T
E
R
T
---
V
-
F
P
F
Q
P
T
Y
H
I
H
S
L
K
E
L
-
M
N
L
L
E
--
12
PsiBlast_PDB
62.76
25%
-93
- C1 -
3D6J
3
?
A:
[5-214]
------
K
Y
T
V
Y
L
F
D
F
D
Y
T
L
A
D
S
S
R
G
I
V
T
C
F
R
S
V
L
E
R
-
H
G
-
Y
T
G
--
I
--
T
D
D
M
I
K
R
T
I
G
--
K
-----------
T
---
L
E
E
----
S
----
F
---
S
----------
I
L
--
T
G
I
-----
T
----
D
----
A
D
Q
L
E
S
F
R
--
Q
E
Y
S
--
K
-----
E
A
-
D
I
Y
--
M
N
-----
A
-------
N
------------------
T
I
L
F
P
D
T
L
P
T
L
T
H
L
K
K
Q
-
G
I
R
I
G
-
I
I
S
T
K
Y
R
F
R
I
L
S
F
L
R
N
H
M
P
D
D
W
F
-
D
I
I
I
G
G
E
---------------
D
V
T
H
H
K
P
D
P
E
---
G
L
L
L
A
I
D
R
L
KA
C
-
P
E
E
V
L
Y
I
G
D
S
T
-
V
D
A
G
T
A
A
A
A
G
V
S
F
T
G
V
T
S
G
M
T
T
A
Q
E
F
-
Q
A
Y
P
Y
D
R
I
I
S
T
L
G
Q
L
-
I
------
6
PsiBlast_PDB
61.79
25%
-104
- C1 -
2HSZ
3
?
A:
[26-243]
----------
I
G
F
D
L
D
G
T
L
V
N
S
L
P
D
L
A
L
S
I
N
S
A
L
K
D
-
V
N
-
L
P
Q
--
A
--
S
E
N
L
V
M
T
W
I
G
NG
A
-----------
D
---
V
L
S
----
Q
----
R
---
A
----------
V
D
--
W
A
C
-----
K
----
Q
----
A
E
K
E
L
T
E
D
E
F
K
Y
F
K
--
R
-----
Q
F
-
G
F
Y
Y
G
E
N
L
CNIS
R
-------
L
------------------
Y
P
N
V
K
E
T
L
E
A
L
K
---
A
Q
-
G
Y
I
L
A
-
V
V
T
N
K
P
T
K
H
V
Q
P
I
L
T
A
F
G
I
D
H
L
F
S
E
M
L
G
G
Q
S
L
P
E
I
K
P
H
P
A
------
P
F
-
Y
Y
L
C
G
K
F
---
G
L
---------
Y
-
P
K
Q
I
L
F
V
G
D
S
Q
-
N
D
I
F
A
A
H
S
A
G
C
A
V
V
G
L
T
Y
G
Y
N
Y
N
I
P
I
-
A
Q
S
K
P
D
W
I
F
D
D
F
A
D
I
-
L
K
I
T
Q
--
38
HHSearch
61.37
22%
-86
- C1 -
3S6J
2
?
A:
[5-221]
------
P
Q
T
S
F
I
F
D
L
D
G
T
L
T
D
S
V
Y
Q
N
V
A
A
W
K
E
A
L
D
A
-
E
N
-
I
P
L
--
A
--
M
-
W
R
I
H
R
K
I
G
--
M
-----------
S
---
G
G
L
----
M
L
K
S
-
L
---
S
----------
R
E
-----------IT--
D
----
E
Q
A
E
R
L
S
E
K
H
A
Q
A
Y
--
E
-----
R
L
--
Q
H
--
Q
I
-----
I
-------
A
------------------
L
P
G
A
V
E
L
L
E
T
L
D
---
K
E
-
N
L
K
W
C
-
I
A
T
S
G
G
I
D
T
A
T
I
N
L
K
A
L
K
L
D
I
N
K
-
I
N
I
V
T
R
D
D
V
S
Y
G
K
P
D
P
------
D
L
F
L
A
A
A
K
K
I
---
G
A
---------
P
-
I
D
E
C
L
V
I
G
D
A
I
-
W
D
M
L
A
A
R
R
C
K
A
T
G
V
G
L
L
S
G
G
Y
D
I
G
E
L
-
E
R
A
G
A
L
R
V
Y
E
D
P
L
D
L
-
L
N
H
L
D
E
I
34
HHSearch
60.75
21%
-126
- C1 -
2GO7
6
?
A:
[4-207]
-------
K
T
A
F
I
W
D
L
D
G
T
L
L
D
S
Y
E
A
I
L
S
G
I
E
E
T
F
A
Q
-
F
S
-
I
P
Y
--
D
--
K
-
E
K
V
R
E
F
I
F
K
-
Y
-----------
S
---
V
Q
D
----
L
L
V
R
-
V
---
A
----------
E
D
--
R
N
L
-----
D
----
V
----
E
V
L
N
Q
V
R
A
Q
S
---
L
--
A
-----
E
K
--
N
A
--
Q
V
-----
V
-------
L
------------------
M
P
G
A
R
E
V
L
A
W
A
D
---
E
S
-
G
I
Q
Q
F
-
I
Y
T
H
K
G
N
-
N
A
F
T
I
L
K
D
L
G
V
E
S
Y
F
-
T
E
I
L
T
S
Q
S
G
F
V
R
K
P
S
P
------
E
A
A
T
Y
L
L
D
K
Y
---
Q
L
---------
N
-
S
D
N
T
Y
Y
I
G
D
R
T
-
L
D
V
E
F
A
Q
N
S
G
I
Q
S
I
N
F
L
E
S
T
Y
---------
E
G
N
H
R
I
Q
A
L
A
D
I
-
S
R
I
F
E
T
K
43
HHSearch
57.82
23%
-91
- C1 -
2HCF
3
?
A:
[3-227]
------
S
R
T
L
V
L
F
D
I
D
G
T
L
L
K
V
E
S
M
N
R
R
V
L
A
D
A
L
I
E
V
Y
G
-
T
E
G
--
S
--
T
-----
D
F
S
G
--
K
-----------
M
---
D
G
A
----
I
I
Y
E
-
V
---
L
----------
S
N
--
V
G
L
-----
E
----
R
A
E
I
A
D
K
F
D
K
A
K
E
T
Y
I
A
L
F
--
R
-----
E
R
A
R
R
E
--
D
I
-----
T
-------
L
------------------
L
E
G
V
R
E
L
L
D
A
L
S
---
S
R
S
D
V
L
L
G
-
L
L
T
G
N
F
E
A
S
G
R
H
K
L
K
L
P
G
I
D
H
Y
F
-
P
F
G
A
F
A
D
D
A
L
D
R
N
E
L
P
------
H
I
A
L
E
R
A
R
R
M
TGA
N
Y
---------
S
-
P
S
Q
I
V
I
I
G
D
T
E
-
H
D
I
R
C
A
R
E
L
D
A
R
S
I
A
V
A
T
G
N
F
T
M
E
E
L
-
A
R
H
K
P
G
T
L
F
K
N
F
A
E
T
-
D
E
V
L
A
S
I
13
PsiBlast_PDB
57.72
21%
-101
- C1 -
2HI0
10
?
A:
[3-224]
------
K
Y
K
A
A
I
F
D
M
D
G
T
I
L
D
T
S
A
D
L
T
S
A
L
N
Y
A
F
E
Q
-
T
G
H
R
H
D
--
F
--
T
V
E
D
I
K
N
F
F
G
--
S
-----------
G
---
V
V
V
----
A
----
V
---
T
----------
R
A
--
L
A
Y
-----
E
----
A
----
G
S
S
R
E
S
L
V
A
F
G
T
K
D
--
E
QIPEA
V
T
-
Q
T
E
--
V
N
-----
R
-------
V
L
E
V
F
K
P
Y
Y
A
D
H
CQIKTGP
F
P
G
I
L
D
L
M
K
N
L
R
---
Q
K
-
G
V
K
L
A
-
V
V
S
N
K
P
N
E
A
V
Q
V
L
V
E
E
L
-
F
P
G
S
F
-
D
F
A
L
G
E
K
S
G
I
R
R
K
P
A
P
------
D
M
T
S
E
C
V
K
V
L
---
G
V
---------
P
-
R
D
K
C
V
Y
I
G
D
S
E
-
I
D
I
Q
T
A
R
N
S
E
M
D
E
I
A
V
N
W
G
F
R
S
V
P
F
L
-
Q
K
H
G
A
T
V
I
V
D
T
A
E
K
L
-
E
E
A
I
L
G
E
41
HHSearch
57.09
16%
-102
- C1 -
1TE2
2
YNIC_ECOLI
A:
[7-221]
-----
R
Q
I
L
A
A
I
F
D
M
D
G
L
L
I
D
S
E
P
L
W
D
R
A
E
L
D
V
M
A
S
-
L
G
-
V
D
I
--
S
--
R
R
N
E
L
P
D
T
L
G
--
L
-----------
R
---
I
D
M
----
V
V
D
L
-
W
---
Y
----------
A
R
--
Q
P
W
-----
N
----
G
----
P
S
R
Q
E
V
V
E
R
V
I
A
R
A
--
I
-----
S
L
-
V
E
E
--
T
R
-----
P
-------
L
------------------
L
P
G
V
R
E
A
V
A
L
C
K
---
E
Q
-
G
L
L
V
G
-
L
A
S
A
S
P
L
H
M
L
E
K
V
L
T
M
F
D
L
R
D
S
F
-
D
A
L
A
S
A
E
K
L
P
Y
S
K
P
H
P
------
Q
V
Y
L
D
C
A
A
K
L
---
G
V
---------
D
-
P
L
T
C
V
A
L
E
D
S
V
-
N
G
M
I
A
S
K
A
A
R
M
R
S
I
V
V
P
A
P
E
A
Q
N
D
P
--
R
F
V
L
A
N
V
K
L
S
S
L
T
E
L
-
T
A
K
D
L
L
G