@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0071: (2015-12-20 )
MFEKAILPLALGACLAFAAPAWAEGDSPDNPKPLADDVALPLPCGGEMVFRHVYVLAEGALDDREVNLGYAFNEGEAGYQQSFISGYRRDYVNGQFSLADLAPAWQQKLSASLPKPAAGTPLKPMLYFIGKYEVTARQYAAVMSQAAALSGQGEAPACDVPDGMAARLPKVNLSRFDAERFGAVYSAWLLKNHPELLPVSGRGKNPEDGGIGFVRLPTEVEWEFAARGGQAVSRQELEGRLFPRKVEGSDQEGPLGDWAVYNQVAGGTGQAARLLPVGMKRPNPLGLFDVIGNAAEMVQESFQLVHAGRRQGTYGGFVVKGGNYLEGEMTLFTGMRREYPLFAADGSEQRNETTGFRVAIGALSAPRSRYPELFAQWQKEGRLAALTDAIDDAQDPTKQLDGIIAATRDPQMQAQLAQINEELKRNVSLIARQREEAAGNLIQSAALVAETINNYNIRLTNLKKDREKAVAARDQATAQLYAGAIANGRSALDGALAIYIDNLATGTRYTDAVIQAQFQRIQEELNRNPVLGKSLVKRATLFVKHVGDYRQQHRAEPEAVLKELLASSGR
Atome Classification :
(20 SA)
-----------------.........10........20........-30........40........50........60.....---...70........80........90........100....--...110.......120--.......130.......140...-----....150.---...---------.-----------------.-----------------..------------------160--..--.......170.......180.......190..----.....200----.....-------------------------...210..--.....220.........230.......240-..--......250..---.....260----....-----....-.270.----------.....-.280.....--...290-........300-----......-----.-----310-----..--.....--..320....--...-----330--........-----------340.......350.......360...----....370.......380.......390...----....400.......410.......420.......430.......440.......--------450.......460----........470.......480.......490.......500--.........510.......520.-----......530-------........540.......550.....----------..560.......570---------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------MFEK
A
I
L
P
L
A
L
G
A
C
L
A
FAAPAWAEGDSPD-NPKPLADDVALPLPCG
G
E
M
V
F
R
H
V
Y
V
LAEGALDD
R
E
V
---
N
L
G
Y
A
FNEGEA
G
Y
Q
Q
S
F
I
S
G
Y
R
R
DYVNG
Q
F
S
L
A
D
L
A
P
A
W
Q
--
Q
K
L
S
ASLPKPAAGTP
L
--
K
P
M
L
Y
FIGKY
E
V
T
A
R
Q
Y
A
A
V
M
S
Q
-----
A
A
ALSG-Q---GEA---------P-----------------A-----------------CD------------------V----PD--
G
M
A
ARLPKVN
L
S
R
F
D
A
E
R
F
G
A
V
Y
S
A
W
L
LKNHP----
E
L
L
PVSG-----RGKNP-------------------------EDG
G
I
G
F
V
--RLP
T
E
V
--
E
W
E
F
AARGGQAV
S
R
Q
E
LEGRL--FP--RKVEGSDQEGP---LG
D
W
A
V
------
Y
N
QV-----AGGT-GQ
A
A
R
----------
L
L
PVG-MKR-PNPL
G
--
L
F
D
V
I--G
N
A
A
E
M
V
Q
E
S
F
-----
Q
L
V
HAG-----R-----R-------QG--TYG
G
F
--
V
V
KGG
N
Y
LE--G
E
M
-----
T
L
---
F
TGMRREY-----------
P
L
F
AADGSEQRNETT
G
F
R
V
A
I
GALSA----
P
R
S
R
Y
P
E
L
F
A
Q
W
Q
KEG
R
L
A
A
L
T
D
AIDDAQ
D
----
P
T
K
Q
L
D
G
I
I
AATR
D
P
Q
M
Q
A
Q
L
A
Q
I
N
E
E
L
K
R
N
V
S
L
I
A
R
Q
R
E
E
A
A
G
N
L
I
Q
S
A
A
L
V
A
--------
E
TINNY
N
I
R
LTN-----LK
K
D
R
E
K
A
V
A
A
R
D
Q
A
T
A
Q
L
Y
A
G
AIANG
R
S
ALD
G
A
L
A
I
Y
I
----DNLATGT
R
Y
T
D
A
V
I
Q
A
Q
F
Q
R
I
Q
E
-----
E
LNRNPVL--------
G
K
S
L
V
K
R
A
T
L
F
V
K
H
V
G
D
Y
R
Q
Q
HRA
E
P
----------
E
A
V
L
K
E
L
L
ASSGR-----------------------------------------------------
35
Fugue
79.54
17%
-21
- C4 -
4UI9
-
APC5_HUMAN
O:
[27-756]
KDWVTPYKIAVLVLLSE
M
S
R
T
G
E
G
A
V
S
L
V
E
R
R
R
L
N
Q
Q
L
L
P
L
L
Q
G
P
D
I
T
V
S
K
L
L
K
L
I
E
E
S
C
P
Q
L
A
N
S
V
Q
I
R
I
K
L
M
A
E
G
E
L
K
D
M
E
Q
FFD
D
L
S
D
S
F
S
G
T
E
P
E
V
H
K
T
S
V
V
G
L
F
L
R
H
M
I
L
A
Y
S
K
L
S
F
S
Q
V
F
K
LY
T
A
L
Q
Q
Y
F
Q
S
D
E
N
K
K
P
L
SQ
K
Q
A
E
F
F
L
S
Q
Q
A
S
L
L
K
N
D
E
T
K
A
L
T
-----
P
A
S
L
Q
K
-
E
---
L
N
N
---------
L
-----------------
L
-----------------
K
F
------------------
N
----
P
D
F-
A
E
A
H
Y
L
S
Y
L
N
N
L
R
V
Q
----
D
V
F
S
S
T
H
S
L
L
H
Y
F
----
D
R
L
I
L
T
G
-----
A
-
E
S
K
-------------------------
S
N
G
E
E
G
Y
G
--
R
S
L
R
Y
A
--
A
L
N
L
A
A
L
H
C
R
F
G
H
Y
Q
Q
A
E
L
A
L
QE
A
I
--
R
I
A
Q
E
S
N
D
H
V
C
---
L
Q
H
C
L
S
------
W
L
Y
V
-----
L
G
Q
K
R
S
D
S
Y
V
----------
L
L
E
H
S
-
V
K
K
-
A
V
H
F
G
LP
Y
L
A
S
L
--
G
I
Q
S
L
V
Q
Q
R
A
F
AGKTA
N
K
L
M
D
A
-----
L
-----
K
-------
D
S
--
D
L
L
H
W
--
K
H
S
L
S
E
L
I
D
--
I
S
I
-----
A
Q
---
K
T
A
I
W
R
L
Y
GRSTMALQQAQ
M
L
L
S
M
N
S
L
E
Q
Q
N
N
T
E
S
F
A
V
A
L
C
H
L
A
E
----
L
H
A
E
----------
Q
G
C
F
A
A
A
S
E
V
L
K
H
L
K
E
RFPP
N
S
Q
H
A
Q
L
W
M
L
C
D
Q
K
I
Q
F
D
R
A
M
N
D
G
K
Y
H
L
A
D
S
L
V
T
G
I
T
A
L
N
S
I
E
G
V
Y
R
K
A
V
V
L
Q
A
QNQMSEAH
K
L
L
Q
K
L
L
V
H
C
Q
K
-----
L
K
N
T
E
M
V
I
S
V
L
L
S
V
A
E
L
Y
W
R
S
S
S
P
T
I
A
L
P
M
L
L
Q
A
L
A
L
S
K
EYRL
Q
Y
L
A
S
E
T
V
L
N
L
A
F
A
Q
L
I
L
G
I
P
E
Q
ALSLL
H
M
A
I
E
P
I
L
ADGAILDK
G
R
A
M
F
L
V
A
K
C
Q
V
A
S
A
A
S
Y
D
Q
P
K
K
A
E
A
L---------
E
A
A
I
E
N
L
N
E
A
K
N
Y
FAKVDCKERIRDVVYFQARLYHTLGKTQERNRCAMLFRQLHQELPSVPLINHL
22
HHSearch
74.19
27%
-25
- C5 -
2Q17
1
?
A:
[54-337]
-----------------------------------------------------------------
S
T
R
G
Q
V
R
L
P
G
G
------
E
F
---
A
M
G
D
A
F
G
E
-------
G
-------------
Y
P
A
D
G
E
T
P
V
H
T
-----------------
V
--
R
L
R
P
F
H
I
D
E
T
A
V
T
N
A
R
F
A
A
F
V
K
A
------
T
G
H
V
T
D
A
E
R
F
G
S
S
A
V
F
HLV
V
A
A
P
DADVLGSAA--------
G
APWWINVRGAHWRRPEG
A
R
------------------
S
----
D
I
--
T
G
R
P
N
H
P
V
V
H
V
S
W
N
D
A
T
A
Y
A
----
R
W
A
G
---------------------------------------------------------
K
--
R
L
P
T
E
A
--
E
W
E
Y
A
A
R
G
G
L
A
-------
G
R
R
--
Y
A
--
W
G
D
E
L
T
-
P
G
G
-----
R
W
R
C
N
------
I
W
Q
G
RFPHV
N
T
A
E
-
D
G
H
L
S
----------
T
A
P
V
K
-
S
Y
R
-
P
N
G
H
G
--
L
W
N
T
A
--
G
N
V
W
E
W
C
S
D
W
F
-----
S
P
T
Y
Y
A
ESPTV
D
-----
P
-------
H
G
PG
T
G
A
A
R
--
V
L
R
G
G
S
Y
L
C
--
H
D
S
-----
Y
C
NRY
R
V
A
A
R
S
S
N
-----------
T
P
------
D
S
S
S
G
N
L
G
F
R
C
A
N
D
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
21
HHSearch
68.62
27%
-24
- C5 -
2Y3C
12
?
A:
[55-293]
------------------------------------------------------------------------------------------------------------------------------------------------
V
--
S
L
S
A
Y
L
I
G
E
T
E
V
T
Q
E
L
W
Q
A
V
M
G
N
-----
N
P
-
S
H
--
F
---
N
G
----------------------------------------------
S
P
------------------
A
----
V
G
--
E
T
Q
G
K
R
P
V
E
N
V
N
W
Y
Q
A
I
A
F
C
----
N
K
L
S
I
K
L
N
----
L
-
E
P
C
Y
T
-----
V
N
V
G
G
NPVDFAALSFDQIPDSNN
A
D
W
D
K
AE
L
D
I
N
K
K
G
F
--
R
L
P
T
E
A
--
E
W
E
W
A
A
K
G
G
T
D
D
--------
K
--
W
S
--
G
T
N
T
E
A
----
E
---
L
K
N
Y
A
W
------
Y
G
S
N
-----
S
------
G
S
K
----------
T
H
E
V
K
-
K
K
K
-
P
N
W
Y
G
--
L
Y
D
I
A
--
G
N
V
A
E
W
C
W
D
W
R
-----
A
D
I
H
T
G
-----
D
S
F
P
QD
Y
-------
P
G
PA
S
G
S
G
R
--
V
L
R
G
G
S
W
A
G
--
S
A
D
-----
Y
C
---
A
V
G
E
R
V
N
I
-----------
S
P
------
G
V
R
C
S
D
L
G
F
R
L
A
C
R
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
24
HHSearch
60.27
23%
-17
- C5 -
1Y4J
4
SUMF2_HUMAN
A:
[31-268]
------------------------------------------------------------------------------------------------------------------------------------------------
A
--
T
V
K
P
F
A
I
D
I
F
P
V
T
N
K
D
F
R
D
F
V
R
E
------
K
K
Y
R
T
E
A
---
E
M
F
---------
G
WSFVFEDFVS
D
E
L
R
N
K
A------------------
Q
P
M
K
S
VLWWLPVEKAFWRQP
A
GPGS
G
I
--
R
E
R
L
E
H
P
V
L
H
V
S
W
N
D
A
R
A
Y
C
----
A
W
R
G
---------------------------------------------------------
K
--
R
L
P
T
E
E
--
E
W
E
F
A
A
R
G
G
L
K
G
-------
Q
V
--
Y
P
--
W
G
N
W
F
---------
Q
P
N
R
T
N
------
L
W
Q
G
KFPKG
D
K
A
E
-
D
G
F
H
G
----------
V
S
P
V
N
-
A
F
P
A
Q
N
N
Y
G
--
L
Y
D
L
L
--
G
N
V
W
E
W
T
A
S
P
Y
-----
Q
A
A
--------------------------
E
Q
D
M
R
--
V
L
R
G
A
S
W
I
D
--
T
A
D
GSANH
R
A
---
R
V
T
T
R
M
G
N
-----------
T
P
------
D
S
A
S
D
N
L
G
F
R
C
A
A
D
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
32
Fugue
54.82
18%
-1
- C5 -
1Y4J
4
SUMF2_HUMAN
A:
[2-268]
-----------------------------------------------------------------------------------------------------------------
T
S
M
V
Q
L
Q
G
G
R
F
L
M
G
--
T
N
S
P
D
S
R
D
G
E
G
P
V
R
E
A
--
T
V
K
P
F
A
I
D
I
F
P
V
T
N
K
D
F
R
D
F
V
R
E
KKYRT
E
A
E
M
F
G
-
W
---
S
F
V
---------
F
-----------------
E
-----------------
D
F
------------------
V
----
S
D
--
E
L
R
N
K
A
Q
P
M
K
S
V
L
W
W
L
P
V
E
K
A
F
W
R
Q
P
A
G
P
G
S
G
IRER
L
E
H
P
V
L
H
-----
V
S
W
N
D
-------------------------
A
R
A
Y
C
A
W
R
G
K
R
L
P
T
E
E
--
E
W
E
F
A
A
R
G
G
L
-------
K
G
Q
V
--
Y
P
--
W
G
N
W
F
Q
P
N
R
T
N
---
L
W
Q
G
K
F
------
P
K
G
D
-----
K
A
E
D
-
G
F
H
G
V
----------
S
P
V
N
A
-
F
P
A
-
Q
N
N
Y
G
--
L
Y
D
L
L
--
G
N
V
W
E
W
T
A
S
P
Y
-----
Q
A
A
E
Q
D
-----
M
---------------------
R
--
V
L
R
G
A
S
W
I
D
--
T
A
D
-----
G
S
---
A
N
H
R
A
R
-
V
-----------
T
T
R
M
G
N
T
P
D
S
A
S
D
N
L
G
F
R
C
A
A
D
A
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
34
Fugue
54.60
12%
-24
* C4 *
3E1S
-
RECDL_DEIRA
A:
[193-720]
------------------
F
T
L
T
E
V
E
----------
G
I
G
F
L
T
A
D
K
L
W
-
D
D
P
R
R
L
T
A
A
A
V
Y
A
L
Q
L
A
G
T
Q
A
G
H
S
F
L
P
R
S
R
A
E
K
G
V
V
H
---
Y
T
R
----------------------
V
T
P
G
Q
A
R
L
A
V
E
T
A
V
E
--
L
G
R
L
S
E
D
D
S
P
L
F
A
A
A
T
--
G
E
G
R
I
Y
L
P
H
V
L
R
A
E
K
K
L
A
S
L
I
R
T
-----
L
L
A
T
P
P
-
A
---
D
------------------------------------------------------------------------
A
G
--
N
D
D
W
A
V
P
K
K
A
R
K
G
L
S
E
E
Q
A
S
V
L
D
Q
L
---
A
G
H
R
----
L
V
V
L
T
G
G
-----
P
G
T
G
K
-------------------------
S
T
T
T
K
A
V
A
--
D
L
A
E
S
L
G
L
E
V
G
L
C
A
P
T
G
K
A
A
R
R
L
G
E
V
T
G
R
--
T
A
--
S
T
V
H
R
L
L
G
Y
G
P
---
Q
G
------------------------------------------
F
R
-
H
N
H
-
L
E
P
A
P
--
Y
D
L
L
I
--
V
D
E
V
S
M
M
G
D
A
L
-----
M
L
S
L
L
A
-----
A
-----
V
-------
P
P
--
G
A
R
V
L
--
L
V
G
D
T
D
Q
L
P
PV
D
A
G
-----
L
P
---
L
L
A
L
A
Q
A
A
-----------
P
T
I
K
L
T
Q
V
Y
R
Q
A
A
K
N
P
I
I
Q
A
A
H
G
L
L
H
GEAP
A
W
G
D
K
R
L
N
L
T
E
I
E
P
D
G
G
A
R
R
V
A
L
M
V
R
E
-
L
G
----
G
P
G
A
V
Q
V
L
T
P
M
R
K
G
P
---
L
G
M
D
H
L
N
Y
H
L
Q
A
L
F
N
P
-
G
E
G
G
V
R
I
A
E
G
E
A
R
P
G
D
T
V
V
--------
Q
T
K
N
D
Y
N
N
E
I
F
N
G
T
L
G
M
V
L
K
A
E
G
A
R
L
T
V
D
F
D
G
N
V
V
E
L
T
G
A
E
L
F
N
---
L
Q
L
G
Y
A
L
T
V
----
H
R
A
Q
-
G
S
E
W
G
-
T
V
L
G
V
L
H
E
A
H
M
P
-----
M
L
S
R
N
L
V
Y
----------
T
A
L
T
R
A
R
D
R
F
F
S
A
G
S
A
S
A
W
Q
I
A
A
A
RQ
R
E
A
R
N
T
A
L
L
E
R
I
R
A
H
L
E
H
H
H
------------------------------------------------------
38
Fugue
53.93
11%
-10
- C3 -
3UEK
-
PARG_RAT
A:
[438-958]
-----------------
Y
V
P
P
N
L
P
P
D
K
K
W
L
G
T
P
I
E
E
M
R
K
M
P
R
C
G
V
R
-
L
P
L
L
R
P
S
A
-------
S
H
T
V
T
V
R
V
D
L
L
R
A
G
E
V
P
K
P
F
P
T
---
H
Y
K
D
L
W
D
N
K
H
V
K
M
P
C
S
E
Q
N
L
Y
P
V
E
D
E
N
G
E
R
T
A
G
S
R
W
E
L
I
Q
--
T
A
L
L
N
K
F
T
R
P
Q
N
L
K
D
A
--
I
L
K
Y
N
V
A
Y
S
K
K
W
D
F
T
A
L
V
D
F
W
D
K
-----
V
L
E
E
A
E
-
A
---
Q
H
L
---------
Y
-----------------
Q
-----------------
S
I
------------------
L
----
P
D
M
V
K
I
A
L
C
L
P
N
I
C
T
Q
P
I
P
L
L
K
Q
K
M
N
H
S
V
T
M
S
Q
E
Q
I
----
A
S
L
L
A
N
A
F
F
CTF
P
R
R
N
A
-------------------------
K
M
K
S
E
Y
S
S
--
Y
P
D
I
N
F
--
N
R
L
F
E
G
R
S
S
R
K
P
E
K
L
K
T
L
F
C
Y
--
F
R
--
R
V
T
E
K
K
----
P
---
T
G
L
V
T
F
------
T
R
Q
S
-----
L
E
D
F
-
P
E
W
E
R
------------------
C
-
D
K
P
L
T
--
R
L
H
V
T
YE
G
T
I
E
G
N
G
R
G
M
L
-----
Q
V
D
F
A
N
-----
R
-----
F
------------
V
G
G
G
--
V
T
G
A
G
-
L
V
Q
--
E
E
I
-----
R
F
---
L
I
N
P
E
L
I
V
-----------
S
R
L
F
T
---
E
V
L
D
H
N
E
C
L
I
I
T
G
T
E
Q
Y
S
----
E
Y
T
G
Y
A
E
T
Y
-
R
W
A
R
S
H
E
D
G
S
E
K
D
D
W
Q
R
C
C
T
----
E
I
V
A
I
D
A
L
H
F
R
R
Y
L
D
Q
F
V
P
E
K
V
R
-
R
E
L
N
K
A
Y
C
G
F
L
R
P
G
V
P
P
E
N
L
S
A
V
A
T
G
N
W
G
C
--------
G
A
F
G
G
D
---------------------
A
R
L
K
A
L
I
Q
L
L
A
A
A
A
A
E
R
------
D
V
V
Y
F
T
----
F
G
--------
D
S
E
L
M
R
D
I
Y
S
M
H
T
-----
F
L
T
E
R
K
L
N
--------
V
G
K
V
Y
R
L
L
L
R
Y
Y
R
E
E
C
R
D
C
S
S
P
G
P
D
T
----------
K
-
L
Y
P
F
I
Y
H
A
A
E
S
-----------------------------------------------------
2
PsiBlast_PDB
45.15
33%
42
- C5 -
2AFT
2
SUMF1_HUMAN
X:
[139-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
T
E
A
--
E
W
E
Y
S
C
R
G
G
-------
L
H
N
R
L
--
F
P
WG
N
K
L
Q
P
K
G
Q
H
Y
A
NIW
Q
G
E
F
P
V
------
T
N
T
G
-----
E
D
G
F
-
Q
G
T
A
-------------
P
V
D
-
A
F
P
-
P
N
G
Y
G
--
L
Y
N
I
V
--
G
N
A
W
E
W
T
S
D
W
W
-----
T
V
H
H
S
V
-----
E
-----
E
TLNP---
K
G
--
P
P
S
G
K
DR
V
K
K
G
G
S
Y
M
S
--
H
R
S
-----
Y
C
---
Y
R
Y
R
C
A
A
R
-----------
S
Q
N
T
P
D
S
S
A
S
N
L
G
F
R
C
A
A
D
R
L
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
PsiBlast_PDB
44.88
33%
43
- C5 -
1Y1F
2
SUMF1_HUMAN
X:
[152-263]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
T
E
A
--
E
W
E
Y
S
C
R
G
G
-------
L
H
N
R
L
--
F
P
WG
N
K
L
Q
P
K
G
Q
H
Y
A
NIW
Q
G
E
F
P
V
------
T
N
T
G
-----
E
D
G
F
-
Q
G
T
A
-------------
P
V
D
-
A
F
P
-
P
N
G
Y
G
--
L
Y
N
I
V
--
G
N
A
W
E
W
T
S
D
W
W
-----
T
V
H
H
S
V
-----
E
-----
E
TLNP---
K
G
--
P
P
S
G
K
DR
V
K
K
G
G
S
Y
M
C
--
H
R
S
-----
Y
C
---
Y
R
Y
R
C
A
A
R
-----------
S
Q
N
T
P
D
S
S
A
S
N
L
G
F
R
C
A
A
D
R
L
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
8
PsiBlast_PDB
44.41
33%
46
- C5 -
2AII
3
SUMF1_HUMAN
X:
[139-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
T
E
A
--
E
W
E
Y
S
C
R
G
G
-------
L
H
N
R
L
--
F
P
WG
N
K
L
Q
P
K
G
Q
H
Y
A
NIW
Q
G
E
F
P
V
------
T
N
T
G
-----
E
D
G
F
-
Q
G
T
A
-------------
P
V
D
-
A
F
P
-
P
N
G
Y
G
--
L
Y
N
I
V
--
G
N
A
W
E
W
T
S
D
W
W
-----
T
V
H
H
S
V
-----
E
-----
E
TLNP---
K
G
--
P
P
S
G
K
DR
V
K
K
G
G
S
Y
M
C
--
H
R
S
-----
Y
C
---
Y
R
Y
R
C
A
A
R
-----------
S
Q
N
T
P
D
S
S
A
S
N
L
G
F
R
C
A
A
D
R
L
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
44.20
33%
49
- C5 -
2HIB
10
SUMF1_HUMAN
X:
[139-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
T
E
A
--
E
W
E
Y
S
C
R
G
G
-------
L
H
N
R
L
--
F
P
WG
N
K
L
Q
P
K
G
Q
H
Y
A
NIW
Q
G
E
F
P
V
------
T
N
T
G
-----
E
D
G
F
-
Q
G
T
A
-------------
P
V
D
-
A
F
P
-
P
N
G
Y
G
--
L
Y
N
I
V
--
G
N
A
W
E
W
T
S
D
W
W
-----
T
V
H
H
S
V
-----
E
-----
E
TLNP---
K
G
--
P
P
S
G
K
DR
V
K
K
G
G
S
Y
M
S
--
H
R
S
-----
Y
C
---
Y
R
Y
R
C
A
A
R
-----------
S
Q
N
T
P
D
S
S
A
S
N
L
G
F
R
C
A
A
D
R
L
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
11
PsiBlast_PDB
44.12
33%
50
- C5 -
1Y1I
2
SUMF1_HUMAN
X:
[152-263]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
T
E
A
--
E
W
E
Y
S
C
R
G
G
-------
L
H
N
R
L
--
F
P
WG
N
K
L
Q
P
K
G
Q
H
Y
A
NIW
Q
G
E
F
P
V
------
T
N
T
G
-----
E
D
G
F
-
Q
G
T
A
-------------
P
V
D
-
A
F
P
-
P
N
G
Y
G
--
L
Y
N
I
V
--
G
N
A
W
E
W
T
S
D
W
W
-----
T
V
H
H
S
V
-----
E
-----
E
TLNP---
K
G
--
P
P
S
G
K
DR
V
K
K
G
G
S
Y
M
C
--
H
R
S
-----
Y
C
---
Y
R
Y
R
C
A
A
R
-----------
S
Q
N
T
P
D
S
S
A
S
N
L
G
F
R
C
A
A
D
R
L
P
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
PsiBlast_PDB
44.11
33%
43
- C5 -
1Y1H
3
SUMF1_HUMAN
X:
[152-263]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
T
E
A
--
E
W
E
Y
S
C
R
G
G
-------
L
H
N
R
L
--
F
P
WG
N
K
L
Q
P
K
G
Q
H
Y
A
NIW
Q
G
E
F
P
V
------
T
N
T
G
-----
E
D
G
F
-
Q
G
T
A
-------------
P
V
D
-
A
F
P
-
P
N
G
Y
G
--
L
Y
N
I
V
--
G
N
A
W
E
W
T
S
D
W
W
-----
T
V
H
H
S
V
-----
E
-----
E
TLNP---
K
G
--
P
P
S
G
K
DR
V
K
K
G
G
S
Y
M
C
--
H
R
S
-----
Y
C
---
Y
R
Y
R
C
A
A
R
-----------
S
Q
N
T
P
D
S
S
A
S
N
L
G
F
R
C
A
A
D
R
L
P
T
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
PsiBlast_PDB
43.78
33%
47
- C5 -
1Y1J
3
SUMF1_HUMAN
X:
[152-262]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
T
E
A
--
E
W
E
Y
S
C
R
G
G
-------
L
H
N
R
L
--
F
P
WG
N
K
L
Q
P
K
G
Q
H
Y
A
NIW
Q
G
E
F
P
V
------
T
N
T
G
-----
E
D
G
F
-
Q
G
T
A
-------------
P
V
D
-
A
F
P
-
P
N
G
Y
G
--
L
Y
N
I
V
--
G
N
A
W
E
W
T
S
D
W
W
-----
T
V
H
H
S
V
-----
E
-----
E
TLNP---
K
G
--
P
P
S
G
K
DR
V
K
K
G
G
S
Y
M
C
--
S
H
R
-----
S
Y
---
C
Y
R
Y
R
C
A
A
-----------
R
S
Q
N
T
P
D
S
S
A
S
N
L
G
F
R
C
A
A
D
R
L
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
9
PsiBlast_PDB
43.69
33%
46
- C5 -
1Y1E
2
SUMF1_HUMAN
X:
[152-263]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
T
E
A
--
E
W
E
Y
S
C
R
G
G
-------
L
H
N
R
L
--
F
P
WG
N
K
L
Q
P
K
G
Q
H
Y
A
NIW
Q
G
E
F
P
V
------
T
N
T
G
-----
E
D
G
F
-
Q
G
T
A
-------------
P
V
D
-
A
F
P
-
P
N
G
Y
G
--
L
Y
N
I
V
--
G
N
A
W
E
W
T
S
D
W
W
-----
T
V
H
H
S
V
-----
E
-----
E
TLNP---
K
G
--
P
P
S
G
K
DR
V
K
K
G
G
S
Y
M
C
--
H
R
S
-----
Y
C
---
Y
R
Y
R
C
A
A
R
-----------
S
Q
N
T
P
D
S
S
A
S
N
L
G
F
R
C
A
A
D
R
L
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_PDB
43.21
33%
47
- C5 -
2AFY
2
SUMF1_HUMAN
X:
[139-249]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
T
E
A
--
E
W
E
Y
S
C
R
G
G
-------
L
H
N
R
L
--
F
P
WG
N
K
L
Q
P
K
G
Q
H
Y
A
NIW
Q
G
E
F
P
V
------
T
N
T
G
-----
E
D
G
F
-
Q
G
T
A
-------------
P
V
D
-
A
F
P
-
P
N
G
Y
G
--
L
Y
N
I
V
--
G
N
A
W
E
W
T
S
D
W
W
-----
T
V
H
H
S
V
-----
E
-----
E
TLNP---
K
G
--
P
P
S
G
K
DR
V
K
K
G
G
S
Y
M
C
--
S
H
R
-----
S
Y
---
S
Y
R
Y
R
C
A
A
-----------
R
S
Q
N
T
P
D
S
S
A
S
N
L
G
F
R
C
A
A
D
R
L
P
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
PsiBlast_PDB
42.77
30%
23
- C5 -
2Q17
1
?
A:
[191-303]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
T
E
A
--
E
W
E
Y
A
A
R
G
G
-----------
L
--
A
G
--
R
R
Y
A
W
G
D
E
L
T
P
---
G
G
R
W
R
C
N
I
W
Q
G
R
F
P
H
V
-----
N
T
A
E
-
D
G
H
L
S
----------
T
A
P
V
K
-
S
Y
R
-
P
N
G
H
G
--
L
W
N
T
A
--
G
N
V
W
E
W
C
S
D
W
F
-----
S
P
T
Y
Y
A
-----
E
-----
S
PTVDPHG
P
G
--
T
G
A
A
R
--
V
L
R
G
G
S
Y
L
C
--
H
D
S
-----
Y
C
---
N
R
Y
R
V
A
A
R
-----------
S
S
N
T
P
D
S
S
S
G
N
L
G
F
R
C
A
N
D
A
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
17
PsiBlast_PDB
41.77
27%
7
- C5 -
1Y4J
3
SUMF2_HUMAN
A:
[136-233]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
T
E
E
--
E
W
E
F
A
A
R
G
G
-------
L
K
G
Q
V
--
Y
-------------
P
---
W
G
N
W
F
Q
------
P
N
R
T
-----
N
L
W
Q
-
G
K
F
P
K
GDKAEDGFHG
V
S
P
V
N
A
F
P
A
-
Q
N
N
Y
G
--
L
Y
D
L
L
--
G
N
V
W
E
W
T
A
S
P
Y
-----
Q
A
A
E
Q
D
-----
M
-----
R
------------------
V
L
R
G
A
S
W
I
D
--
T
A
D
-----
G
S
---
A
N
H
R
A
R
V
T
-----------
T
R
M
G
N
T
P
D
S
A
S
D
N
L
G
F
R
C
A
A
D
A
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
14
PsiBlast_PDB
41.31
33%
56
- C5 -
1Y1G
2
SUMF1_HUMAN
X:
[152-261]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
T
E
A
--
E
W
E
Y
S
C
R
G
G
-------
L
H
N
R
L
--
F
P
WG
N
K
L
Q
P
K
G
Q
H
Y
A
NIW
Q
G
E
F
P
V
------
T
N
T
G
-----
E
D
G
F
-
Q
G
T
A
-------------
P
V
D
-
A
F
P
-
P
N
G
Y
G
--
L
Y
N
I
V
--
G
N
A
W
E
W
T
S
D
W
W
-----
T
V
H
H
S
V
-----
E
-----
E
TLNP---
K
G
--
P
P
S
G
K
DR
V
K
K
G
G
S
Y
M
C
--
S
H
R
-----
S
Y
---
C
S
Y
R
Y
R
C
A
-----------
A
R
S
Q
N
T
P
D
S
S
A
S
N
L
G
F
R
C
A
A
D
R
L
P
T
M
----
D
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
40.37
33%
57
- C5 -
2AIJ
4
SUMF1_HUMAN
X:
[139-250]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
L
P
T
E
A
--
E
W
E
Y
S
C
R
G
G
-------
L
H
N
R
L
--
F
P
WG
N
K
L
Q
P
K
G
Q
H
Y
A
NIW
Q
G
E
F
P
V
------
T
N
T
G
-----
E
D
G
F
-
Q
G
T
A
-------------
P
V
D
-
A
F
P
-
P
N
G
Y
G
--
L
Y
N
I
V
--
G
N
A
W
E
W
T
S
D
W
W
-----
T
V
H
H
S
V
-----
E
-----
E
TLNP---
K
G
--
P
P
S
G
K
DR
V
K
K
G
G
S
Y
M
S
--
H
R
S
-----
Y
C
---
Y
R
Y
R
C
A
A
R
-----------
S
Q
N
T
P
D
S
S
A
S
N
L
G
F
R
C
A
A
D
R
L
P
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------