@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0089: (2015-12-21 )
MAGEAGQPSEPLNLLAGMAAAPWDYDFFQALRRIECESPQLPRLGHSVRLADDPLRLGQKPDCTFAPSTLASVSQAGTAAVPRLDQFFFGLTGPNGPLPLHLTEYARERQRNVNDATFKRFMDVFHHRLLTLFYRAWAEARPEISHDRIDDDYWSARLAALSGRGMPSLRGREPLADTARYYYTGHLAAQTRYPDGLRVILAEYFEVPVAVEEYVGQWLELPERSRLGVDSTSLGMDVCLGTHVWDRQHKFRLRLGPLDLDQYQRFLPDGDHFVELAAWVAEYLGEELDWDVNLVLQRHEVPPLGLQGGGRLGFNTWLGDPGQDARDLLLARQYATARPHEHKEKEHE
Atome Classification :
(18 SA)
-----------------------------------------------------------------------------------......------...10-----........20........30-........40....-....50-------...--...--------..60....--------..--..70.......----.80...----------.....90.....-...100......--------.110.......120.-.......130--------.......140-----.--------.......-.--150-.......----.160..---------....---------.170..-..-----.----..180--.........190.-......-----200.......210-.......220.......230-----......-.240..-.....250.......260.......270--.......280....-----...290---.........300...------.-.--------..310.--.---------..------..---.320......----------..330-----........----340......---
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----------------------------------------------------------------------------------MAGEAG------QPS
E
P
-----
L
N
L
L
A
GMAAAPW
D
Y
D
F
F
Q
A
L
-
R
RIECESPQLPRLG-
H
S
V
RLA-------D
D
P
--
L
RL--------GQKPDCTF--------A
P
--
S
T
L
A
S
V
S
QAGT----AAV
P
R
L
----------
D
Q
F
F
FGLTGPNG-
P
L
P
L
H
L
T
E
Y
A
R
E
--------
R
QRNV
N
D
A
T
F
K
R
-
F
M
-
D
V
F
H
H
R
L
L
T
L
--------
F
Y
R
A
W
A
EA-------R--------PEISHDR-I--D
D
--
D
Y
W
S
A
R
L
----
A
A
LSGR---------GMPS---------LRGREP-LA-----D----T
A
R
----
Y
Y
Y
T
G
H
L
A
AQTRY-PD
G
L
R
V
-----
I
L
A
E
YFEV
P
V
A
V
E
-
E
Y
V
G
Q
W
L
ELP
E
R
SRLGVDST-----SLG
M
D
V
-
C
LGTHV-WDRQ
H
K
F
R
L
RLGPL
D
L
D
Q
Y
Q
R
FLPDG
D
H
--
F
V
E
L
A
A
W
V
A
E
Y
LGE-----ELDW-----D
V
N
L
V
L
QRHEVPPLG------L-Q--------GGGRLG--F---------NT------WL---GDP-G
Q
D
A
R
D
----------
L
L
L
A
------
R
Q
YATARP----HEHKEKEHE---
22
Fugue
88.89
20%
-37
- C2 -
4USR
2
?
A:
[1-357]
-------------------------------------------------------------------------------------
G
P
A
M
------
P
P
I
L
D
-----
V
I
V
I
G
G
G
Q
A
A
L
T
T
A
Y
F
L
R
R
T
-
S
L
S
Y
L
L
L
D
E
Q
P
G
P
G
-
G
A
W
L
H
A
-------
W
D
S
--
L
R
L
---------------
F
--------
S
P
--
A
A
W
S
S
I
A
------------------------
G
W
P
M
P
S
P
T
E
P
G
N
-
P
T
R
N
D
V
I
D
Y
L
R
R
Y
E
D
R
Y
QFP
I
Q
R
P
V
R
V
D
T
V
T
R
-
L
D
-
D
L
W
R
V
Q
A
G
D
Q
--------
Q
W
L
A
R
A
V
I
S
ATGTWS
K
--------
P
F
I
P
P
Y
E
-
G
--
R
E
--
L
F
Q
G
A
Q
I
----
H
S
A
H
Y
R
---------
T
P
A
P
---------
F
A
G
K
R
V
-
M
V
V
G
GG
N
S
----
G
A
Q
----
V
L
A
E
L
S
S
V
S
E
T
L
W
I
T
Q
E
P
P
A
-----
F
L
P
D
E
V
D
G
R
V
L
F
E
-
R
A
T
A
R
W
K
A
Q
Q
E
G
R
S
I
D
E
P
A
G
-----
G
F
G
-
D
I
-
V
M
V
P
P
V
-
R
E
A
R
E
R
G
V
L
V
A
E
R
----
P
F
A
R
F
T
E
T
G
-----
V
E
W
A
D
G
R
R
E
N
L
-
D
-----
A
V
I
W
-----
C
S
G
F
R
P
A
L
D
H
L
R
E
L
G
------
V
V
E
--------
A
D
G
K
V
Q
--
V
EDTRVVKQP
N
L
------
W
L
V
GY
G
D
W
T
G
M
A
S
A
T
----------
L
I
G
V
------
T
R
T
A
R
S
T
A
----
D
Q
V
V
Q
A
L
T
A
TP-
13
Fugue
85.56
17%
-36
- C5 -
4LYP
3
?
A:
[34-449]
-------------------------------------------------------------------------------SEFA
F
V
K
I
A
S
DGK
G
F
T
R
Y
G
E
P
Y
L
I
RG
A
N
Y
W
Q
G
M
N
L
G
A
D
D
C
S
G
G
D
-
R
-
K
R
M
E
L
E
I
K
Q
M
A
E
M
G
I
N
N
L
R
V
M
A
S
S
E
G
PD
D
Q
P
--
Y
R
M
RPSMMPQP
G
K
Y
N
E
G
V
F
--------
V
G
L
D
Y
L
L
D
T
M
D
R
Y
N
M
----
T
A
V
M
T
L
GNFWQWSGG
F
G
Q
Y
V
A
W
I
T
G
N
Q
T
I
P
Y
P
V
G
D
V
T
Y
D
E
F
--------
T
Q
F
A
A
R
F
Y
N
D
S
E
-
I
A
-
P
K
A
N
K
L
F
K
D
H
--------
I
Y
T
V
Q
N
R
R
-------
N
--------
T
V
N
G
K
I
Y
-
K
--
E
D
--
P
V
I
M
S
W
Q
----
I
A
N
E
P
Q
---------
E
A
P
A
---------
S
W
F
E
E
I
-
S
T
-----
F
----
I
K
K
G
A
PK
H
L
V
S
A
G
L
E
S
K
L
D
E
-
Y
D
F
D
R
A
-----
H
D
H
K
N
I
D
Y
-
T
T
C
H
-
C
W
V
E
N
W
G
I
Y
D
P
A
D
P
D
G
L
P
H
A
-----
N
E
Y
M
H
D
-
F
L
E
S
R
S
K
W
A
A
Q
L
N
K
P
I
V
M
E
E
F
G
M
A
R
D
A
W
R
N
P
E
D
E
T
--
Y
K
Y
L
P
S
T
P
T
S
H
K
D
E
-----
Y
Y
Q
K
-----
A
F
N
Q
I
V
S
L
A
S
N
R
S
F
S
G
S
N
F
WA
Y
-
G
--------
G
E
G
R
S
T
--
Y
---------
P
P
NPYGMV
W
L
---
G
D
P
-
P
H
E
P
H
G
W
Y
S
V
Y
SND
T
T
V
Q
I
I
------
K
D
Y
N
A
N
L
L
----
K
V
Q
K
E
L
S
K
----
18
Fugue
83.95
15%
-50
- C5 -
1E6V
3
MCRA_METKA
A:
[273-552]
-------------------------------------------------------------------------------------
R
R
A
R
------
G
E
N
E
P
-----
G
G
V
P
F
G
V
L
A
D
C
---------------------------
V
Q
T
M
-------
R
K
---------------------
Y
--------
P
D
--
D
P
A
K
V
A
L
E
V
I
A
----
A
G
A
M
L
Y
----------
D
Q
I
W
L
G
S
Y
M
S
G
G
-
V
---
G
F
T
Q
Y
A
T
----------------
A
V
Y
P
D
N
I
L
-
D
D
Y
V
Y
Y
G
L
E
Y
--------
V
E
D
K
Y
-
G
I
-------
A
--------------
E
-
A
EP
S
M
--
D
V
V
K
D
V
A
----
T
E
V
T
L
Y
---------
G
L
E
Q
---------
Y
E
R
Y
P
A
-
A
M
-----
E
----
T
------
H
F
G
G
S
Q
R
A
A
V
C
A
A
-
A
A
G
C
S
T
-----
A
F
A
T
G
H
A
Q
A
G
L
N
G
-
W
Y
L
S
Q
I
L
H
K
E
G
Q
G
R
L
G
F
Y
G
Y
-----
A
L
-
Q
D
Q
-
C
G
A
A
N
S
-
L
S
V
R
S
D
E
G
L
P
L
E
L
R
G
P
N
-
Y
P
N
Y
A
M
N
V
G
H
--
L
G
E
Y
A
G
I
V
Q
A
A
H
A
A
-----
R
G
D
A
-----
F
C
V
H
P
V
I
K
V
A
F
A
D
E
N
------
L
-
V
--------
F
-------------------------------
D
F
-
T
E
P
R
K
E
----------
F
A
K
G
------
A
L
R
E
F
E
P
A
----
G
E
R
D
L
I
V
P
A
---
15
Fugue
79.77
21%
-16
- C3 -
4BIJ
-
TERL_BPT7
A:
[1-476]
----------M
S
T
Q
S
N
R
N
A
L
V
V
A
Q
L
K
G
D
F
V
A
F
L
F
V
LWKALNLPVPT
K
C
Q
I
D
M
A
K
V
L
ANGDNK
K
F
I
L
QAFRGIG
K
S
F
I
T
C
A
F
V
V
W
S
L
W
R
D
------
P
Q
L
K
I
-----
L
I
V
S
A
S
K
E
R
A
D
A
N
S
I
F
I
K
N
I
I
D
L
L
P
F
L
S
E
L
K
P
R
P
G
-
Q
R
-----------
D
S
V
--
I
S
F
--------
D
V
G
P
A
N
P
D
--------
H
S
--
P
S
V
K
S
V
G
I
T
G
Q
----
L
T
G
S
R
A
----------
D
I
I
I
A
D
----
D
V
-
E
I
P
S
N
S
A
T
M
G
A
R
--------
E
K
L
W
T
L
V
Q
E
F
A
A
-
L
L
K
P
L
P
S
S
R
V
I
Y
L
G
T
P
Q
T
EM
T
L
Y
K
E
L
E
D
N
-------
R
G
YTTI
I
W
P
A
L
Y
P
R
T
R
-
E
--
E
N
--
L
Y
Y
S
Q
R
L
----
A
M
L
R
A
E
Y
D
E
N
PEA
L
A
G
T
P
T
D
PVRFDRDD
L
R
E
R
E
L
-
E
Y
-----
G
K
A
G
F
T
L
Q
----
F
M
L
N
P
N
L
S
D
A
E
K
Y
-
P
L
R
L
R
-----------
D
A
I
V
A
A
L
D
L
E
K
A
M
H
Y
Q
W
L
P
N
R
Q
N
I
I
E
D
L
P
-----
N
V
G
L
K
G
D
D
L
H
T
Y
H
-
D
C
S
N
N
S
G
Q
Y
Q
Q
K
I
L
V
I
D
P
S
G
R
G
K
D
E
T
G
Y
--
A
V
L
Y
T
L
N
G
Y
I
Y
L
M
E
-----
A
G
G
F
RDGYS
D
K
T
L
E
L
L
A
K
K
A
K
Q
W
G
------
V
-
Q
T
V
V
Y
E
S
N
F
G
D
G
M
F
G
K
V
F
---------
S
P
------
I
L
---
L
K
H
-
H
N
C
A
M
E
----------
E
I
R
A
R
G
MKEM
R
I
C
D
T
L
E
P
V
M
Q
T
H
R
L
V
I
R
D
E
V
---
19
Fugue
60.89
10%
-33
- C5 -
4LT5
16
?
A:
[63-327]
----------------------------------------------------------------------------------------
I
------
N
K
K
S
L
-----
L
Q
N
L
L
S
K
C
K
T
T
F
Q
Q
S
F
T
N
A
N
-
I
T
L
K
-
D
E
K
W
L
K
N
V
R
-
T
A
Y
F
V
C
-------
D
H
D
GS
V
E
L
--------
A
Y
L
P
N
V
L
P
--------
K
E
--
L
V
E
E
F
T
E
K
F
E
S
----
I
Q
T
G
R
K
----------
K
D
T
G
Y
S
G
I
L
D
N
S
-
M
P
F
N
Y
V
T
A
D
L
S
Q
--------
E
L
G
Q
Y
L
S
E
I
V
N
P
-
Q
I
-
N
Y
Y
I
S
K
L
L
T
C
--------
V
S
S
R
T
I
N
Y
-------
L
--------
V
S
L
N
D
S
Y
-
Y
--
A
L
N
N
C
L
Y
P
S
T
A
----
F
N
S
L
K
P
---------
S
N
D
G
---------
H
R
I
R
K
P
-
H
K
-----
D
----
N
L
D
----
I
T
P
S
S
L
F
Y
F
G
N
F
Q
-
N
T
E
G
Y
L
-----
E
L
T
D
K
------------
N
C
K
V
F
V
Q
P
G
D
V
L
F
F
K
G
N
-----
E
Y
-----------------------------------------------------------------------------
K
H
V
V
A
N
I
---------
T
--------
S
G
W
R
I
G
--
L
---------
V
Y
------
F
A
---
H
K
G
-
S
K
T
K
P
Y
----------
Y
E
D
T
------
Q
K
N
S
L
K
I
H
----
K
E
T
K
--------
17
Fugue
60.81
10%
-46
- C4 -
1HM9
6
GLMU_STRPN
A:
[11-468]
S
N
F
A
I
I
L
A
AGKGTRMKSDLPKVLHKVAGIS
M
L
E
H
V
F
R
S
V
G
A
I
QPE
K
T
V
T
V
V
G
HK
A
E
L
V
E
E
V
LAGQ
T
E
F
V
T
QSEQLG
T
G
H
A
V
M
M
T
E
P
I
L
E
------
G
L
S
G
H
-----
T
L
V
I
A
G
D
T
P
L
I
T
G
E
S
L
K
N
L
I
-
D
F
H
I
N
H
K
N
V
A
T
I
L
T
-
A
E
T
D
N
P
-------
F
G
Y
--
G
R
I
--------
V
R
N
D
N
A
E
V
L
R
I
V
E
QKD
A
T
--
D
F
E
K
Q
I
K
E
I
N
T
G
T
Y
V
F
D
N
E
R
L
----------
F
E
A
L
K
N
I
N
T
N
N
A
-
Q
G
E
Y
Y
I
T
D
V
I
G
I
--------
F
R
E
T
G
E
K
V
G
A
Y
T
-
L
K
-
D
--
F
D
E
S
L
G
V
--------
N
D
R
V
A
L
A
T
-------
A
--------
E
S
V
M
R
R
R
-
I
--
N
H
--
K
H
M
V
N
G
V
----
S
F
V
N
P
E
---------
A
T
-
Y
---------
I
D
I
D
V
E
-
I
A
-----
P
----
E
V
Q
----
I
E
A
N
V
I
L
K
G
Q
T
K
I
-
G
A
E
T
V
L
T
NG
T
Y
V
V
D
S
T
I
G
A
G
A
V
I
T
-
N
S
M
I
E
E
S
S
V
A
D
G
V
T
V
G
P
Y
A
H
I
R
P
N
S
S
L
G
A
Q
V
-
H
I
G
N
F
V
-
E
V
K
G
S
S
I
G
E
N
T
K
A
G
H
L
T
Y
I
G
N
C
E
V
G
S
N
V
--
N
F
G
A
G
T
I
T
V
N
Y
D
G
K
N
K
Y
K
T
V
I
G
D
-----
N
V
F
V
G
S
N
S
T
I
I
A
P
V
E
------
L
-
G
--------
D
N
S
L
V
G
--
A
---------
G
S
------
T
I
---
T
K
D
-
V
P
A
D
A
I
----------
A
I
G
R
------
G
R
Q
I
N
K
D
E
----
Y
A
T
R
L
P
H
H
P
KNQ
2
PsiBlast_PDB
46.26
31%
7
- C6 -
2F1D
-
HIS5A_ARATH
A:
[134-179]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
V
G
T
----
Y
D
T
Q
L
V
----------
E
H
F
F
Q
S
L
V
N
T
S
G
--
M
T
L
H
I
R
Q
L
A
G
E
--------
N
S
H
H
I
I
E
A
T
F
K
A
-
F
A
-
R
A
L
R
Q
A
T
E
T
D
--------
P
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
12
HHSearch
42.21
18%
7
* C6 *
2J49
-
TAF5_YEAST
A:
[239-279]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
H
K
Y
R
I
T
M
S
K
T
T
L
N
L
L
L
Y
F
L
N
E
N
E
S
IG
G
S
L
I
I
S
V
I
N
Q
H
L
D
P
-----------------------------------------------------------------------------------------------------------------------------------
8
HHSearch
38.72
24%
26
- C6 -
2L1N
-
?
A:
[4-36]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
T
I
T
D
E
L
L
W
A
I
L
K
D
E
L
S
--
D
A
E
A
N
A
L
V
W
Q
A
L
G
Y
-----
V
W
D
E
-----
A
Q
S
C
W
K
T
D
L
V
A
P
E
W
R
------
Q
-
D
--------
Y
P
E
P
P
D
--
F
---------
I
A
------
S
R
---
P
A
T
-
V
K
L
T
R
S
----------
I
P
A
P
------
Y
K
Q
L
L
K
E
E
----
L
G
F
A
G
Y
S
I
N
---
1
PsiBlast_PDB
38.69
33%
12
- C6 -
3C85
1
?
A:
[81-149]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
G
-------
R
--------
N
V
I
S
G
D
A
-
T
--
D
P
--
D
F
W
E
R
I
L
DTGH
V
K
L
V
L
L
---------
A
M
P
H
---------
H
Q
G
N
Q
T
A
L
E
-----
Q
----
L
Q
R
----
R
N
Y
K
G
Q
I
A
A
I
A
E
Y
-
P
D
Q
L
E
G
-----
L
L
E
S
G
V
D
A
A
F
N
I
Y
-
S
E
A
G
S
G
F
A
R
H
V
C
K
Q
L
E
P
Q
F
T
-----
S
I
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
Fugue
35.96
15%
6
* C5 *
2GV5
-
SFI1_YEAST
C:
[638-710]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
P
L
G
S
K
L
N
D
I
L
H
V
Y
E
K
S
--------
K
E
R
E
L
Q
S
Q
L
F
N
A
-
W
R
-
N
R
F
C
F
Y
T
E
E
C
--------
N
I
Q
A
I
S
K
R
-------
N
--------
Y
Q
L
E
--
K
M
V
--
L
K
--
K
F
R
E
R
L
L
----
E
I
V
K
S
E
---------
E
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
HHSearch
34.55
18%
133
- C6 -
3PF6
-
?
A:
[27-48]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
E
A
R
L
L
F
P
G
G
T
H
--
H
D
F
M
R
A
L
M
G
Y
H
N
T
L
-----
V
K
V
M
-----
E
E
Q
C
-----------------------------------------------------------------------------------------------------------------
11
HHSearch
28.95
14%
43
- C6 -
2H9A
3
?
A:
[408-441]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
G
V
A
-
V
L
S
G
K
L
-
Q
E
-
L
S
G
W
E
I
L
V
G
P
R
E
S
S
G
I
N
S
F
I
K
Q
------------------------------------------------------------------------------------------------------------------------------------------------------
7
HHSearch
24.17
33%
357
- C6 -
1ZL8
-
?
A:
[37-48]
--------------------------------------------------------------------------------------------------------------------
L
Q
S
E
F
F
G
A
V
-
R
E
V
Y
E
T
V
Y
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
5
HHSearch
23.54
19%
194
- C6 -
3LQV
-
SF3B1_HUMAN
P:
[18-38]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
R
N
R
P
L
S
D
E
E
L
D
A
M
F
P
--
E
G
--
Y
K
V
L
---------------------------------------------------------------------------------------------------------------------------------------------
3
HHSearch
16.81
23%
138
- C6 -
1FME
-
?
A:
[3-28]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Y
T
A
K
Y
K
G
--------
R
T
-
F
R
N
E
K
E
L
R
D
-
F
I
-
E
K
F
K
G
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
10
HHSearch
11.64
24%
208
- C6 -
2FHO
-
SF3B1_HUMAN
A:
[395-415]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
R
N
R
P
L
S
D
E
E
L
D
A
M
F
P
--
E
G
--
Y
K
V
L
---------------------------------------------------------------------------------------------------------------------------------------------
9
HHSearch
1.64
18%
410
- C1 -
2I2J
-
?
A:
[4-14]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
S
T
-
F
F
-
R
L
F
N
R
S
F
T
Q
A
--------
L
G
K
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------