@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0130: (2015-12-23 )
MGTLHHLINGEMVADNGRSADVFNPSTGEAIHKVPLADGKTLQKAIDAARAAFPAWRNTPPAKRAQVLYRFKQLLEQNEARISKLISEEHGKTLEDAAGELKRGIENVEYACAAPEILKGEYSRNVGPNIDAWSDFQPIGVVAGITPFNFPAMVPLWMYPLAIACGNTFILKPSERDPSSTLLIAELFHEAGLPKGVLNVVHGDKEAVDGLLQAPEVKAISFVGSTPIAEYIYAEGTKRGKRVQALGGAKNHAVLMPDADLDNAVSALMGAAYGSCGERCMAISVAVCVGDQVADALIAKLVPQIKALKIGAGTSCGLDMGPLVTAAAQAKVTGYIDSGVAQGAELVVDGRGYQVAGHENGFFLGGSLFDRVTPEMTIYKEEIFGPVLCVVRVNSLEEAMQLINDHEYGNGTCIFTRDGEAARLFCDEIEVGMVGVNVPLPVPVAYHSFGGWKRSLFGDLHAYGPDGVRFYTRRKAITQRWPQRASHEASQFAFPSL
Atome Classification :
(20 SA)
.........10..--.-.-....20.....-...30........40........50..---.---.--....60........70........80........90......-.-.100........110.......120.......130....------...140.......150.......160.......170.......180.......190.......200.-.-.-....210...-....220.......230.-...-...240.......250.......260....-...270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450......-.460.......470.......480.......490.....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MG
T
L
H
H
LIN
G
E
M
V--A-D-NGRSADVFNPS-TGE
A
I
H
KVPLAD
G
K
T
L
Q
K
A
I
D
A
A
R
A
AF---P---A--WRNTP
P
A
K
R
A
Q
V
L
Y
R
F
K
Q
L
L
E
Q
N
E
A
R
I
S
K
L
I
S
E
EHGK
T
L
E
D
A
-
A
-
G
E
-
L
K
R
G
I
E
NVEYACAA
P
E
I
L
K
G
E
YSRNVGPNIDAWSDF------QP
I
G
V
V
AGITPFNFPAM
V
P
L
W
M
Y
P
L
AIACG
N
T
F
I
L
KPSERDPS
S
T
L
L
I
A
E
L
F
H
EAGL
P
K
G
V
L
N
V
VHG-
D
-
K
-
E
A
V
D
G
L
LQAP-E
V
K
A
I
S
FVGST
P
I
A
E
Y
I
Y
-AEG-TKRG
K
R
V
Q
ALGGAKN
H
A
V
L
MPDA
D
L
D
N
A
V
S
-
A
L
M
G
A
A
Y
G
S
CG
E
R
C
M
A
I
S
V
A
VCV
G
D
Q
V
A
D
A
L
I
A
K
L
V
P
Q
I
K
A
L
KIGAGTSCGLDM
G
P
L
V
T
A
AAQ
A
K
V
T
G
Y
IDSGVAQG
A
E
L
V
V
DGR
G
Y
Q
V
AGHEN
G
F
F
L
G
G
S
L
F
D
RVTPE
M
T
I
Y
K
E
EIFG
P
V
L
C
V
V
R
V
N
S
L
E
E
A
M
Q
L
I
NDHEYGN
G
T
C
I
F
TRDG
E
A
A
R
L
F
C
D
EIEV
G
M
V
GVNVPLPV
P
V
A
YHSFGG
W
K
R
S
L
FG-
D
L
HAYGPDG
V
R
F
Y
T
R
R
K
A
I
T
Q
RW
P
Q
RASH
E
A
S
QFAFPSL
2
PsiBlast_PDB
99.01
54%
-108
- C2 -
4IYM
3
?
A:
[27-511]
---
L
G
H
F
I
D
G
K
R
V
--
A
G
T
-
S
G
R
V
S
N
I
F
N
P
A
-
T
G
E
V
Q
G
T
V
A
L
A
S
D
A
D
L
A
A
A
V
E
S
A
K
A
A
Q
---
P
---
K
--
W
A
A
T
N
P
Q
R
R
A
R
V
F
M
K
F
V
Q
L
L
N
D
N
M
N
E
L
A
E
M
L
S
R
E
H
G
K
T
I
D
D
A
-
K
-
G
D
-
I
V
R
G
L
E
V
C
E
F
V
I
G
I
P
H
L
Q
K
S
E
F
T
E
G
A
G
P
G
I
D
M
Y
S
I
R
------
Q
P
V
G
I
G
A
G
I
T
P
F
N
F
P
G
M
I
P
M
W
M
F
A
P
A
I
A
C
G
N
A
F
I
L
K
P
S
E
R
D
P
S
V
P
I
R
L
A
E
L
M
I
E
A
G
L
P
A
G
I
L
N
V
V
N
G
-
D
-
K
-
G
A
V
D
A
I
L
T
H
P
-
D
I
A
A
V
S
F
V
G
S
T
P
I
A
R
Y
V
Y
-
G
T
A
-
A
M
N
G
K
R
A
Q
C
F
G
G
A
K
N
H
M
I
I
M
P
D
A
D
L
D
Q
A
A
N
-
A
L
I
G
A
G
Y
G
S
A
G
E
R
C
M
A
I
S
V
A
V
P
V
G
E
E
T
A
N
R
L
I
D
K
L
V
P
M
V
E
S
L
R
I
G
P
Y
T
D
E
K
A
D
M
G
P
V
V
T
K
E
A
E
Q
R
I
R
S
L
I
D
S
G
I
E
Q
G
A
K
L
V
V
D
G
R
D
F
K
L
Q
G
Y
E
N
G
H
F
I
G
G
C
L
F
D
D
V
T
P
D
M
D
I
Y
K
T
E
I
F
G
P
V
L
S
V
V
R
A
R
N
Y
E
E
A
L
S
L
P
M
K
H
E
Y
G
N
G
V
A
I
Y
T
R
D
G
D
A
A
R
D
F
A
S
R
I
N
I
G
M
V
G
V
N
V
P
I
P
V
P
L
A
Y
H
S
F
G
G
W
K
S
S
S
F
G
-
D
L
N
Q
H
G
T
D
S
I
K
F
W
T
R
T
K
T
I
T
S
R
W
P
S
-
G
I
K
D
---------
112
HHSearch
95.28
47%
-103
- C2 -
1T90
1
IOLA_BACSU
A:
[3-485]
I
R
K
L
K
N
Y
I
N
G
E
W
V
--
E
-
S
K
T
D
Q
Y
E
D
V
V
N
P
A
-
T
K
E
V
L
C
Q
V
P
I
S
T
K
E
D
I
D
Y
A
A
Q
T
A
A
E
A
F
---
K
---
T
--
W
S
K
V
A
V
P
R
R
A
R
I
L
F
N
F
Q
Q
L
L
S
Q
H
K
E
E
L
A
H
L
I
T
I
E
N
G
K
N
T
K
E
A
-
L
-
G
E
-
V
G
R
G
I
E
N
V
E
F
A
A
G
A
P
S
L
M
M
G
D
S
L
A
S
I
A
T
D
V
E
A
A
N
Y
R
------
Y
P
I
G
V
V
G
G
I
A
P
F
N
F
P
M
M
V
P
C
W
M
F
P
M
A
I
A
L
G
N
T
F
I
L
K
P
S
E
R
T
P
L
L
T
E
K
L
V
E
L
F
E
K
A
G
L
P
K
G
V
F
N
V
V
Y
G
-
A
-
H
-
D
V
V
N
G
I
L
E
H
P
-
E
I
K
A
I
S
F
V
G
S
K
P
V
G
E
Y
V
Y
-
K
K
G
-
S
E
N
L
K
R
V
Q
S
L
T
G
A
K
N
H
T
I
V
L
N
D
A
N
L
E
D
T
V
T
-
N
I
V
G
A
A
F
G
S
A
G
E
R
C
M
A
C
A
V
-
V
T
V
E
E
G
I
A
D
E
F
M
A
K
L
Q
E
K
V
A
D
I
K
I
G
N
G
L
D
D
G
V
F
L
G
P
V
I
R
E
D
N
K
K
R
T
L
S
Y
I
E
K
G
L
E
E
G
A
R
L
V
C
D
G
R
E
N
V
---
S
D
D
G
Y
F
V
G
P
T
I
F
D
N
V
T
T
E
M
T
I
W
K
D
E
I
F
A
P
V
L
S
V
I
R
V
K
N
L
K
E
A
I
E
I
A
N
K
S
E
F
A
N
G
A
C
L
F
T
S
N
S
N
A
I
R
Y
F
R
E
N
I
D
A
G
M
L
G
I
N
L
G
V
P
A
P
M
A
F
F
P
F
S
G
W
K
S
S
F
F
G
-
T
L
H
A
N
G
K
D
S
V
D
F
Y
T
R
K
K
V
V
T
A
R
Y
P
A
P
D
F
-----------
21
PsiBlast_CBE
94.86
47%
-104
- C2 -
1T90
1
IOLA_BACSU
D:
[6-481]
---
L
K
N
Y
I
N
G
E
W
V
E-
S
-
K
-
T
D
Q
Y
E
D
V
V
N
P
A
-
T
K
E
V
L
C
Q
V
P
I
S
T
K
E
D
I
D
Y
A
A
Q
T
A
A
E
A
F
---
K
---
T
--
W
S
K
V
A
V
P
R
R
A
R
I
L
F
N
F
Q
Q
L
L
S
Q
H
K
E
E
L
A
H
L
I
T
I
E
N
G
K
N
T
K
E
A
-
L
-
G
E
-
V
G
R
G
I
E
N
V
E
F
A
A
G
A
P
S
L
M
M
G
D
S
L
A
S
I
A
T
D
V
E
A
A
N
Y
R
------
Y
P
I
G
V
V
G
G
I
A
P
F
N
F
P
M
M
V
P
C
W
M
F
P
M
A
I
A
L
G
N
T
F
I
L
K
P
S
E
R
T
P
L
L
T
E
K
L
V
E
L
F
E
K
A
G
L
P
K
G
V
F
N
V
V
Y
G
-
A
-
H
-
D
V
V
N
G
I
L
E
H
P
-
E
I
K
A
I
S
F
V
G
S
K
P
V
G
E
Y
V
Y
-
K
K
G
-
S
E
N
L
K
R
V
Q
S
L
T
G
A
K
N
H
T
I
V
L
N
D
A
N
L
E
D
T
V
T
-
N
I
V
G
A
A
F
G
S
A
G
E
R
C
M
A
C
A
V
-
V
T
V
E
E
G
I
A
D
E
F
M
A
K
L
Q
E
K
V
A
D
I
K
I
G
N
G
L
D
D
G
V
F
L
G
P
V
I
R
E
D
N
K
K
R
T
L
S
Y
I
E
K
G
L
E
E
G
A
R
L
V
C
D
G
R
E
N
V
---
S
D
D
G
Y
F
V
G
P
T
I
F
D
N
V
T
T
E
M
T
I
W
K
D
E
I
F
A
P
V
L
S
V
I
R
V
K
N
L
K
E
A
I
E
I
A
N
K
S
E
F
A
N
G
A
C
L
F
T
S
N
S
N
A
I
R
Y
F
R
E
N
I
D
A
G
M
L
G
I
N
L
G
V
P
A
P
M
A
F
F
P
F
S
G
W
K
S
S
F
F
G
-
T
L
H
A
N
G
K
D
S
V
D
F
Y
T
R
K
K
V
V
T
A
R
Y
P
A
P
D
F
-----------
3
PsiBlast_PDB
94.36
47%
-104
- C2 -
1T90
1
IOLA_BACSU
A:
[6-481]
---
L
K
N
Y
I
N
G
E
W
V
E
-
S
-
K
-
T
D
Q
Y
E
D
V
V
N
P
A
-
T
K
E
V
L
C
Q
V
P
I
S
T
K
E
D
I
D
Y
A
A
Q
T
A
A
E
A
F
---
K
---
T
--
W
S
K
V
A
V
P
R
R
A
R
I
L
F
N
F
Q
Q
L
L
S
Q
H
K
E
E
L
A
H
L
I
T
I
E
N
G
K
N
T
K
E
A
-
L
-
G
E
-
V
G
R
G
I
E
N
V
E
F
A
A
G
A
P
S
L
M
M
G
D
S
L
A
S
I
A
T
D
V
E
A
A
N
Y
R
------
Y
P
I
G
V
V
G
G
I
A
P
F
N
F
P
M
M
V
P
C
W
M
F
P
M
A
I
A
L
G
N
T
F
I
L
K
P
S
E
R
T
P
L
L
T
E
K
L
V
E
L
F
E
K
A
G
L
P
K
G
V
F
N
V
V
Y
G
-
A
-
H
-
D
V
V
N
G
I
L
E
H
P
-
E
I
K
A
I
S
F
V
G
S
K
P
V
G
E
Y
V
Y
-
K
K
G
-
S
E
N
L
K
R
V
Q
S
L
T
G
A
K
N
H
T
I
V
L
N
D
A
N
L
E
D
T
V
T
-
N
I
V
G
A
A
F
G
S
A
G
E
R
C
M
A
C
A
V
-
V
T
V
E
E
G
I
A
D
E
F
M
A
K
L
Q
E
K
V
A
D
I
K
I
G
N
G
L
D
D
G
V
F
L
G
P
V
I
R
E
D
N
K
K
R
T
L
S
Y
I
E
K
G
L
E
E
G
A
R
L
V
C
D
G
R
E
N
V
---
S
D
D
G
Y
F
V
G
P
T
I
F
D
N
V
T
T
E
M
T
I
W
K
D
E
I
F
A
P
V
L
S
V
I
R
V
K
N
L
K
E
A
I
E
I
A
N
K
S
E
F
A
N
G
A
C
L
F
T
S
N
S
N
A
I
R
Y
F
R
E
N
I
D
A
G
M
L
G
I
N
L
G
V
P
A
P
M
A
F
F
P
F
S
G
W
K
S
S
F
F
G
-
T
L
H
A
N
G
K
D
S
V
D
F
Y
T
R
K
K
V
V
T
A
R
Y
P
A
P
D
F
-----------
23
PsiBlast_CBE
94.00
47%
-103
- C2 -
1T90
1
IOLA_BACSU
B:
[6-481]
---
L
K
N
Y
I
N
G
E
W
V
E-
S
-
K
-
T
D
Q
Y
E
D
V
V
N
P
A
-
T
K
E
V
L
C
Q
V
P
I
S
T
K
E
D
I
D
Y
A
A
Q
T
A
A
E
A
F
---
K
---
T
--
W
S
K
V
A
V
P
R
R
A
R
I
L
F
N
F
Q
Q
L
L
S
Q
H
K
E
E
L
A
H
L
I
T
I
E
N
G
K
N
T
K
E
A
-
L
-
G
E
-
V
G
R
G
I
E
N
V
E
F
A
A
G
A
P
S
L
M
M
G
D
S
L
A
S
I
A
T
D
V
E
A
A
N
Y
R
------
Y
P
I
G
V
V
G
G
I
A
P
F
N
F
P
M
M
V
P
C
W
M
F
P
M
A
I
A
L
G
N
T
F
I
L
K
P
S
E
R
T
P
L
L
T
E
K
L
V
E
L
F
E
K
A
G
L
P
K
G
V
F
N
V
V
Y
G
-
A
-
H
-
D
V
V
N
G
I
L
E
H
P
-
E
I
K
A
I
S
F
V
G
S
K
P
V
G
E
Y
V
Y
-
K
K
G
-
S
E
N
L
K
R
V
Q
S
L
T
G
A
K
N
H
T
I
V
L
N
D
A
N
L
E
D
T
V
T
-
N
I
V
G
A
A
F
G
S
A
G
E
R
C
M
A
C
A
V
-
V
T
V
E
E
G
I
A
D
E
F
M
A
K
L
Q
E
K
V
A
D
I
K
I
G
N
G
L
D
D
G
V
F
L
G
P
V
I
R
E
D
N
K
K
R
T
L
S
Y
I
E
K
G
L
E
E
G
A
R
L
V
C
D
G
R
E
N
V
---
S
D
D
G
Y
F
V
G
P
T
I
F
D
N
V
T
T
E
M
T
I
W
K
D
E
I
F
A
P
V
L
S
V
I
R
V
K
N
L
K
E
A
I
E
I
A
N
K
S
E
F
A
N
G
A
C
L
F
T
S
N
S
N
A
I
R
Y
F
R
E
N
I
D
A
G
M
L
G
I
N
L
G
V
P
A
P
M
A
F
F
P
F
S
G
W
K
S
S
F
F
G
-
T
L
H
A
N
G
K
D
S
V
D
F
Y
T
R
K
K
V
V
T
A
R
Y
P
A
P
D
F
-----------
22
PsiBlast_CBE
93.36
47%
-104
- C2 -
1T90
1
IOLA_BACSU
C:
[6-481]
---
L
K
N
Y
I
N
G
E
W
V
E-
S
-
K
-
T
D
Q
Y
E
D
V
V
N
P
A
-
T
K
E
V
L
C
Q
V
P
I
S
T
K
E
D
I
D
Y
A
A
Q
T
A
A
E
A
F
---
K
---
T
--
W
S
K
V
A
V
P
R
R
A
R
I
L
F
N
F
Q
Q
L
L
S
Q
H
K
E
E
L
A
H
L
I
T
I
E
N
G
K
N
T
K
E
A
-
L
-
G
E
-
V
G
R
G
I
E
N
V
E
F
A
A
G
A
P
S
L
M
M
G
D
S
L
A
S
I
A
T
D
V
E
A
A
N
Y
R
------
Y
P
I
G
V
V
G
G
I
A
P
F
N
F
P
M
M
V
P
C
W
M
F
P
M
A
I
A
L
G
N
T
F
I
L
K
P
S
E
R
T
P
L
L
T
E
K
L
V
E
L
F
E
K
A
G
L
P
K
G
V
F
N
V
V
Y
G
-
A
-
H
-
D
V
V
N
G
I
L
E
H
P
-
E
I
K
A
I
S
F
V
G
S
K
P
V
G
E
Y
V
Y
-
K
K
G
-
S
E
N
L
K
R
V
Q
S
L
T
G
A
K
N
H
T
I
V
L
N
D
A
N
L
E
D
T
V
T
-
N
I
V
G
A
A
F
G
S
A
G
E
R
C
M
A
C
A
V
-
V
T
V
E
E
G
I
A
D
E
F
M
A
K
L
Q
E
K
V
A
D
I
K
I
G
N
G
L
D
D
G
V
F
L
G
P
V
I
R
E
D
N
K
K
R
T
L
S
Y
I
E
K
G
L
E
E
G
A
R
L
V
C
D
G
R
E
N
V
---
S
D
D
G
Y
F
V
G
P
T
I
F
D
N
V
T
T
E
M
T
I
W
K
D
E
I
F
A
P
V
L
S
V
I
R
V
K
N
L
K
E
A
I
E
I
A
N
K
S
E
F
A
N
G
A
C
L
F
T
S
N
S
N
A
I
R
Y
F
R
E
N
I
D
A
G
M
L
G
I
N
L
G
V
P
A
P
M
A
F
F
P
F
S
G
W
K
S
S
F
F
G
-
T
L
H
A
N
G
K
D
S
V
D
F
Y
T
R
K
K
V
V
T
A
R
Y
P
A
P
D
F
-----------
115
HHSearch
86.38
30%
-96
- C2 -
3U4J
1
?
A:
[21-502]
-
S
R
Y
Q
M
L
V
D
G
K
S
V
--
D
A
A
-
S
G
S
T
I
D
R
V
S
P
G
H
A
G
E
V
V
G
T
W
P
E
A
S
A
D
D
V
R
K
A
V
A
A
A
R
K
A
F
---
D
AG-
P
--
W
P
R
M
S
G
A
E
R
S
R
L
M
F
K
V
A
D
L
I
L
A
R
Q
E
E
L
A
L
I
E
S
L
E
V
G
K
P
I
A
Q
A
-
R
-
G
E
-
I
G
F
C
A
D
L
W
S
Y
A
A
G
Q
A
R
A
L
E
G
Q
T
H
N
N
I
G
D
D
R
L
G
L
V
L
R
------
E
P
V
G
V
V
G
I
I
T
P
W
N
F
P
F
I
I
A
S
E
R
V
P
W
A
I
G
S
G
C
T
V
V
L
K
P
S
E
F
T
S
G
T
S
I
R
L
A
E
L
A
R
E
A
G
I
P
D
G
V
F
N
V
V
T
G
-
Y
-
G
D
P
A
G
Q
V
L
A
E
D
P
-
N
V
D
M
V
A
F
T
G
S
V
R
V
G
T
K
L
G
-
E
I
A
-
A
R
T
V
K
R
V
G
L
E
L
G
G
K
G
P
Q
I
V
F
A
D
A
D
L
D
A
A
A
D
-
G
I
A
Y
G
V
Y
H
N
A
G
Q
C
C
I
S
G
S
R
-
L
L
V
Q
E
G
I
R
D
A
L
M
E
R
L
L
D
I
S
R
K
V
A
F
G
D
P
L
N
E
R
T
K
I
G
A
M
I
S
E
A
H
A
E
K
V
H
S
Y
V
T
A
G
I
T
S
G
A
E
L
L
L
G
G
E
R
I
G
---
R
E
A
G
L
Y
Y
A
P
T
V
F
A
G
V
T
P
D
M
S
I
A
R
E
E
I
F
G
P
V
L
S
T
L
T
F
K
T
A
D
E
A
V
A
L
A
N
A
T
E
F
G
L
S
A
S
V
W
S
T
N
L
E
T
A
L
Q
T
I
R
R
I
R
A
G
R
C
W
I
N
S
V
I
D
G
-
T
P
E
L
P
I
G
G
Y
K
K
S
G
L
G
-
R
E
--
L
G
R
Y
G
F
D
E
Y
S
Q
F
K
G
V
H
V
T
L
G
R
P
A
P
W
F
T
--------
61
PsiBlast_CBE
85.17
32%
-94
- C2 -
4O6R
5
?
B:
[14-482]
------
F
I
D
G
R
F
V
DA
V
-
D
-
R
G
-
T
I
D
V
L
N
P
H
-
D
G
S
V
I
T
K
I
A
A
A
T
A
A
D
V
D
L
A
V
D
A
A
T
R
A
F
---
P
---
A
--
W
S
A
M
P
A
A
E
R
G
R
L
L
L
R
L
A
D
A
I
E
A
N
T
E
A
L
A
Q
L
E
S
L
D
T
G
H
P
I
R
D
S
R
A
-
L
D
-
V
P
R
T
A
A
C
F
R
Y
F
G
G
M
A
D
K
L
Q
G
S
V
I
-
P
V
D
T
G
F
L
N
Y
V
Q
R
------
A
P
I
G
V
V
G
Q
I
V
P
W
N
F
P
L
M
F
T
S
W
K
M
G
P
A
L
A
A
G
N
T
V
V
L
K
P
S
E
I
T
P
L
S
T
L
R
I
V
E
L
M
A
E
V
G
F
P
A
G
V
V
N
I
V
P
G
Y
G
-
H
-
T
A
G
Q
R
L
A
E
H
P
-
G
V
G
K
I
A
F
T
G
S
T
A
T
G
R
R
I
V
-
E
A
S
-
Q
G
N
L
K
R
V
Q
L
E
L
G
G
K
G
A
N
I
V
F
D
D
A
N
L
D
A
A
I
N
-
G
A
A
W
A
I
F
H
N
Q
G
Q
A
C
I
A
G
S
R
L
V
-
L
H
E
R
I
A
D
A
F
L
E
R
F
V
A
L
A
S
S
I
R
I
G
N
P
L
D
P
N
T
E
M
G
P
L
T
S
K
Q
H
L
D
R
V
L
S
Y
V
D
V
A
R
E
Q
G
G
R
V
L
T
G
G
S
A
P
Q
D
P
A
L
A
N
G
Y
Y
V
R
P
T
I
V
E
A
K
H
A
T
D
R
V
A
Q
E
E
V
F
G
P
F
V
T
V
L
R
F
G
S
D
D
E
A
L
A
I
A
N
A
T
E
Y
G
L
G
S
G
L
W
T
N
D
L
S
R
A
H
R
M
A
A
R
I
D
A
G
M
C
W
I
N
C
Y
K
R
V
N
P
G
-
S
P
F
G
G
V
G
K
S
G
Y
G
---
R
E
M
G
F
E
A
M
H
D
Y
T
E
A
R
S
V
W
V
N
V
D
G
N
V
P
P
H
F
K
R
------
46
PsiBlast_CBE
84.98
31%
-95
- C2 -
4QF6
2
?
B:
[20-489]
---
I
K
M
F
I
N
G
E
F
V
S
-
A
-
I
-
G
G
K
T
F
E
T
Y
N
P
A
-
T
E
D
V
L
A
V
V
C
E
A
Q
E
E
D
I
D
A
A
V
K
A
A
R
S
A
F
---
E
---
S
GP
W
A
E
M
T
T
A
E
R
A
H
L
I
Y
K
L
A
D
L
I
E
E
H
R
E
E
L
A
Q
L
E
A
L
D
N
G
K
P
Y
Q
V
A
-
L
-
D
D
D
I
S
A
T
V
E
N
Y
R
Y
Y
A
-------
G
W
T
T
K
I
I
G
Q
T
I
P
I
S
K
D
Y
L
N
Y
T
R
H
E
P
V
G
V
V
G
Q
I
I
P
W
N
F
P
L
V
M
S
S
W
K
M
G
A
A
L
A
T
G
C
T
I
V
L
K
P
A
S
Q
T
P
L
S
L
L
Y
A
A
K
L
F
K
E
A
G
F
P
N
G
V
V
N
F
V
P
G
F
G
-
P
-
E
A
G
A
A
I
V
N
H
H
-
D
I
D
K
V
A
F
T
G
S
T
V
T
G
K
Y
I
M
-
R
Q
S
-
A
E
M
I
K
H
V
T
L
E
L
G
G
K
S
P
N
I
I
L
E
D
A
D
L
E
E
A
I
N
G
A
F
Q
G
I
M
Y
-
N
H
G
Q
N
C
S
A
G
S
-
R
V
F
V
H
R
K
H
Y
E
T
V
V
D
A
L
V
K
M
A
N
N
V
K
L
G
A
G
M
E
K
E
T
E
M
G
P
L
V
S
K
K
Q
Q
E
R
V
L
N
Y
I
E
Q
G
K
K
E
G
A
T
V
A
A
G
G
E
----
R
A
L
E
K
G
Y
F
V
K
P
T
V
F
T
D
V
T
D
D
M
T
I
V
K
E
E
I
F
G
P
V
V
V
V
L
P
F
D
S
T
E
E
V
I
E
R
A
N
N
S
S
Y
G
L
A
A
G
V
W
T
Q
N
I
K
T
G
H
Q
V
A
N
K
L
K
A
G
T
V
W
I
N
-
D
Y
N
L
E
N
A
A
A
P
F
G
G
Y
K
Q
S
G
I
G
R
E
L
G
S
Y
A
L
D
N
---
Y
T
E
V
K
S
V
W
V
N
I
K
---------------
132
HHSearch
84.97
31%
-97
* C2 *
1O04
2
ALDH2_HUMAN
A:
[18-499]
-
F
C
N
Q
I
F
I
N
N
E
W
H
--
D
A
V
-
S
R
K
T
F
P
T
V
N
P
S
-
T
G
E
V
I
C
Q
V
A
E
G
D
K
E
D
V
D
K
A
V
K
A
A
R
A
A
F
---
Q
LGS
P
--
W
R
R
M
D
A
S
H
R
G
R
L
L
N
R
L
A
D
L
I
E
R
D
R
T
Y
L
A
A
L
E
T
L
D
N
G
K
P
Y
V
I
S
-
Y
L
V
D
-
L
D
M
V
L
K
C
L
R
Y
Y
A
G
W
A
D
K
Y
H
G
K
T
I
-
P
I
D
G
D
F
F
S
Y
T
R
H
------
E
P
V
G
V
C
G
Q
I
I
P
W
N
F
P
L
L
M
Q
A
W
K
L
G
P
A
L
A
T
G
N
V
V
V
M
K
V
A
E
Q
T
P
L
T
A
L
Y
V
A
N
L
I
K
E
A
G
F
P
P
G
V
V
N
I
V
P
G
-
F
G
P
-
T
A
G
A
A
I
A
S
H
E
-
D
V
D
K
V
A
F
T
G
S
T
E
I
G
R
V
I
Q
-
V
A
A
G
S
S
N
L
K
R
V
T
L
E
L
G
G
K
S
P
N
I
I
M
S
D
A
D
M
D
W
A
V
E
-
Q
A
H
F
A
L
F
F
N
Q
G
Q
C
S
C
A
G
S
R
-
T
F
V
Q
E
D
I
Y
D
E
F
V
E
R
S
V
A
R
A
K
S
R
V
V
G
N
P
F
D
S
K
T
E
Q
G
P
Q
V
D
E
T
Q
F
K
K
I
L
G
Y
I
N
T
G
K
Q
E
G
A
K
L
L
C
G
G
G
I
A
----
A
D
R
G
Y
F
I
Q
P
T
V
F
G
D
V
Q
D
G
M
T
I
A
K
E
E
I
F
G
P
V
M
Q
I
L
K
F
K
T
I
E
E
V
V
G
R
A
N
N
S
T
Y
G
L
A
A
A
V
F
T
K
D
L
D
K
A
N
Y
L
S
Q
A
L
Q
A
G
T
V
W
V
N
C
Y
D
V
F
-
G
A
Q
S
P
F
G
G
Y
K
M
S
G
S
G
-
R
E
--
L
G
E
Y
G
L
Q
A
Y
T
E
V
K
T
V
T
V
K
V
P
Q
K
N
S
-----------
42
PsiBlast_CBE
84.71
31%
-93
- C2 -
4QF6
2
?
F:
[20-489]
---
I
K
M
F
I
N
G
E
F
V
S-
A
-
I
-
G
G
K
T
F
E
T
Y
N
P
A
-
T
E
D
V
L
A
V
V
C
E
A
Q
E
E
D
I
D
A
A
V
K
A
A
R
S
A
F
---
E
---
S
GP
W
A
E
M
T
T
A
E
R
A
H
L
I
Y
K
L
A
D
L
I
E
E
H
R
E
E
L
A
Q
L
E
A
L
D
N
G
K
P
Y
Q
V
A
-
L
-
D
D
D
I
S
A
T
V
E
N
Y
R
Y
Y
A
-------
G
W
T
T
K
I
I
G
Q
T
I
P
I
S
K
D
Y
LNYTRH
E
P
V
G
V
V
G
Q
I
I
P
W
N
F
P
L
V
M
S
S
W
K
M
G
A
A
L
A
T
G
C
T
I
V
L
K
P
A
S
Q
T
P
L
S
L
L
Y
A
A
K
L
F
K
E
A
G
F
P
N
G
V
V
N
F
V
P
G
F
G
-
P
-
E
A
G
A
A
I
V
N
H
H
-
D
I
D
K
V
A
F
T
G
S
T
V
T
G
K
Y
I
M
-
R
Q
S
-
A
E
M
I
K
H
V
T
L
E
L
G
G
K
S
P
N
I
I
L
E
D
A
D
L
E
E
A
I
N
G
A
F
Q
G
I
M
Y
-
N
H
G
Q
N
C
S
A
G
S
-
R
V
F
V
H
R
K
H
Y
E
T
V
V
D
A
L
V
K
M
A
N
N
V
K
L
G
A
G
M
E
K
E
T
E
M
G
P
L
V
S
K
K
Q
Q
E
R
V
L
N
Y
I
E
Q
G
K
K
E
G
A
T
V
A
A
G
G
E
----
R
A
L
E
K
G
Y
F
V
K
P
T
V
F
T
D
V
T
D
D
M
T
I
V
K
E
E
I
F
G
P
V
V
V
V
L
P
F
D
S
T
E
E
V
I
E
R
A
N
N
S
S
Y
G
L
A
A
G
V
W
T
Q
N
I
K
T
G
H
Q
V
A
N
K
L
K
A
G
T
V
W
I
N
-
D
Y
N
L
E
N
A
A
A
P
F
G
G
Y
K
Q
S
G
I
G
R
E
L
G
S
Y
A
L
D
N
---
Y
T
E
V
K
S
V
W
V
N
I
K
---------------
41
PsiBlast_CBE
84.57
31%
-94
- C2 -
4QF6
2
?
G:
[20-489]
---
I
K
M
F
I
N
G
E
F
V
S-
A
-
I
-
G
G
K
T
F
E
T
Y
N
P
A
-
T
E
D
V
L
A
V
V
C
E
A
Q
E
E
D
I
D
A
A
V
K
A
A
R
S
A
F
---
E
---
S
GP
W
A
E
M
T
T
A
E
R
A
H
L
I
Y
K
L
A
D
L
I
E
E
H
R
E
E
L
A
Q
L
E
A
L
D
N
G
K
P
Y
Q
V
A
-
L
-
D
D
D
I
S
A
T
V
E
N
Y
R
Y
Y
A
-------
G
W
T
T
K
I
I
G
Q
T
I
P
I
S
K
D
Y
LNYTRH
E
P
V
G
V
V
G
Q
I
I
P
W
N
F
P
L
V
M
S
S
W
K
M
G
A
A
L
A
T
G
C
T
I
V
L
K
P
A
S
Q
T
P
L
S
L
L
Y
A
A
K
L
F
K
E
A
G
F
P
N
G
V
V
N
F
V
P
G
F
G
-
P
-
E
A
G
A
A
I
V
N
H
H
-
D
I
D
K
V
A
F
T
G
S
T
V
T
G
K
Y
I
M
-
R
Q
S
-
A
E
M
I
K
H
V
T
L
E
L
G
G
K
S
P
N
I
I
L
E
D
A
D
L
E
E
A
I
N
G
A
F
Q
G
I
M
Y
-
N
H
G
Q
N
C
S
A
G
S
-
R
V
F
V
H
R
K
H
Y
E
T
V
V
D
A
L
V
K
M
A
N
N
V
K
L
G
A
G
M
E
K
E
T
E
M
G
P
L
V
S
K
K
Q
Q
E
R
V
L
N
Y
I
E
Q
G
K
K
E
G
A
T
V
A
A
G
G
E
----
R
A
L
E
K
G
Y
F
V
K
P
T
V
F
T
D
V
T
D
D
M
T
I
V
K
E
E
I
F
G
P
V
V
V
V
L
P
F
D
S
T
E
E
V
I
E
R
A
N
N
S
S
Y
G
L
A
A
G
V
W
T
Q
N
I
K
T
G
H
Q
V
A
N
K
L
K
A
G
T
V
W
I
N
-
D
Y
N
L
E
N
A
A
A
P
F
G
G
Y
K
Q
S
G
I
G
R
E
L
G
S
Y
A
L
D
N
---
Y
T
E
V
K
S
V
W
V
N
I
K
---------------
60
PsiBlast_CBE
84.55
32%
-93
- C2 -
4O6R
9
?
C:
[14-482]
------
F
I
D
G
R
F
V
DA
V
-
D
-
R
G
-
T
I
D
V
L
N
P
H
-
D
G
S
V
I
T
K
I
A
A
A
T
A
A
D
V
D
L
A
V
D
A
A
T
R
A
F
---
P
---
A
--
W
S
A
M
P
A
A
E
R
G
R
L
L
L
R
L
A
D
A
I
E
A
N
T
E
A
L
A
Q
L
E
S
L
D
T
G
H
P
I
R
D
S
R
A
-
L
D
-
V
P
R
T
A
A
C
F
R
Y
F
G
G
M
A
D
K
L
Q
G
S
V
I
-
P
V
D
T
G
F
L
N
Y
V
Q
R
------
A
P
I
G
V
V
G
Q
I
V
P
W
N
F
P
L
M
F
T
S
W
K
M
G
P
A
L
A
A
G
N
T
V
V
L
K
P
S
E
I
T
P
L
S
T
L
R
I
V
E
L
M
A
E
V
G
F
P
A
G
V
V
N
I
V
P
G
Y
G
-
H
-
T
A
G
Q
R
L
A
E
H
P
-
G
V
G
K
I
A
F
T
G
S
T
A
T
G
R
R
I
V
-
E
A
S
-
Q
G
N
L
K
R
V
Q
L
E
L
G
G
K
G
A
N
I
V
F
D
D
A
N
L
D
A
A
I
N
-
G
A
A
W
A
I
F
H
N
Q
G
Q
A
C
I
A
G
S
R
L
V
-
L
H
E
R
I
A
D
A
F
L
E
R
F
V
A
L
A
S
S
I
R
I
G
N
P
L
D
P
N
T
E
M
G
P
L
T
S
K
Q
H
L
D
R
V
L
S
Y
V
D
V
A
R
E
Q
G
G
R
V
L
T
G
G
S
A
P
Q
D
P
A
L
A
N
G
Y
Y
V
R
P
T
I
V
E
A
K
H
A
T
D
R
V
A
Q
E
E
V
F
G
P
F
V
T
V
L
R
F
G
S
D
D
E
A
L
A
I
A
N
A
T
E
Y
G
L
G
S
G
L
W
T
N
D
L
S
R
A
H
R
M
A
A
R
I
D
A
G
M
C
W
I
N
C
Y
K
R
V
N
P
G
-
S
P
F
G
G
V
G
K
S
G
Y
G
---
R
E
M
G
F
E
A
M
H
D
Y
T
E
A
R
S
V
W
V
N
V
D
G
N
V
P
P
H
F
K
R
------
43
PsiBlast_CBE
84.49
31%
-93
- C2 -
4QF6
3
?
E:
[20-489]
---
I
K
M
F
I
N
G
E
F
V
S-
A
-
I
-
G
G
K
T
F
E
T
Y
N
P
A
-
T
E
D
V
L
A
V
V
C
E
A
Q
E
E
D
I
D
A
A
V
K
A
A
R
S
A
F
---
E
---
S
GP
W
A
E
M
T
T
A
E
R
A
H
L
I
Y
K
L
A
D
L
I
E
E
H
R
E
E
L
A
Q
L
E
A
L
D
N
G
K
P
Y
Q
V
A
-
L
-
D
D
D
I
S
A
T
V
E
N
Y
R
Y
Y
A
-------
G
W
T
T
K
I
I
G
Q
T
I
P
I
S
K
D
Y
LNYTRH
E
P
V
G
V
V
G
Q
I
I
P
W
N
F
P
L
V
M
S
S
W
K
M
G
A
A
L
A
T
G
C
T
I
V
L
K
P
A
S
Q
T
P
L
S
L
L
Y
A
A
K
L
F
K
E
A
G
F
P
N
G
V
V
N
F
V
P
G
F
G
-
P
-
E
A
G
A
A
I
V
N
H
H
-
D
I
D
K
V
A
F
T
G
S
T
V
T
G
K
Y
I
M
-
R
Q
S
-
A
E
M
I
K
H
V
T
L
E
L
G
G
K
S
P
N
I
I
L
E
D
A
D
L
E
E
A
I
N
G
A
F
Q
G
I
M
Y
-
N
H
G
Q
N
C
S
A
G
S
-
R
V
F
V
H
R
K
H
Y
E
T
V
V
D
A
L
V
K
M
A
N
N
V
K
L
G
A
G
M
E
K
E
T
E
M
G
P
L
V
S
K
K
Q
Q
E
R
V
L
N
Y
I
E
Q
G
K
K
E
G
A
T
V
A
A
G
G
E
----
R
A
L
E
K
G
Y
F
V
K
P
T
V
F
T
D
V
T
D
D
M
T
I
V
K
E
E
I
F
G
P
V
V
V
V
L
P
F
D
S
T
E
E
V
I
E
R
A
N
N
S
S
Y
G
L
A
A
G
V
W
T
Q
N
I
K
T
G
H
Q
V
A
N
K
L
K
A
G
T
V
W
I
N
-
D
Y
N
L
E
N
A
A
A
P
F
G
G
Y
K
Q
S
G
I
G
R
E
L
G
S
Y
A
L
D
N
---
Y
T
E
V
K
S
V
W
V
N
I
K
---------------
39
PsiBlast_CBE
84.46
31%
-94
- C2 -
4QF6
1
?
I:
[20-489]
---
I
K
M
F
I
N
G
E
F
V
S-
A
-
I
-
G
G
K
T
F
E
T
Y
N
P
A
-
T
E
D
V
L
A
V
V
C
E
A
Q
E
E
D
I
D
A
A
V
K
A
A
R
S
A
F
---
E
---
S
GP
W
A
E
M
T
T
A
E
R
A
H
L
I
Y
K
L
A
D
L
I
E
E
H
R
E
E
L
A
Q
L
E
A
L
D
N
G
K
P
Y
Q
V
A
-
L
-
D
D
D
I
S
A
T
V
E
N
Y
R
Y
Y
A
-------
G
W
T
T
K
I
I
G
Q
T
I
P
I
S
K
D
Y
LNYTRH
E
P
V
G
V
V
G
Q
I
I
P
W
N
F
P
L
V
M
S
S
W
K
M
G
A
A
L
A
T
G
C
T
I
V
L
K
P
A
S
Q
T
P
L
S
L
L
Y
A
A
K
L
F
K
E
A
G
F
P
N
G
V
V
N
F
V
P
G
F
G
-
P
-
E
A
G
A
A
I
V
N
H
H
-
D
I
D
K
V
A
F
T
G
S
T
V
T
G
K
Y
I
M
-
R
Q
S
-
A
E
M
I
K
H
V
T
L
E
L
G
G
K
S
P
N
I
I
L
E
D
A
D
L
E
E
A
I
N
G
A
F
Q
G
I
M
Y
-
N
H
G
Q
N
C
S
A
G
S
-
R
V
F
V
H
R
K
H
Y
E
T
V
V
D
A
L
V
K
M
A
N
N
V
K
L
G
A
G
M
E
K
E
T
E
M
G
P
L
V
S
K
K
Q
Q
E
R
V
L
N
Y
I
E
Q
G
K
K
E
G
A
T
V
A
A
G
G
E
----
R
A
L
E
K
G
Y
F
V
K
P
T
V
F
T
D
V
T
D
D
M
T
I
V
K
E
E
I
F
G
P
V
V
V
V
L
P
F
D
S
T
E
E
V
I
E
R
A
N
N
S
S
Y
G
L
A
A
G
V
W
T
Q
N
I
K
T
G
H
Q
V
A
N
K
L
K
A
G
T
V
W
I
N
-
D
Y
N
L
E
N
A
A
A
P
F
G
G
Y
K
Q
S
G
I
G
R
E
L
G
S
Y
A
L
D
N
---
Y
T
E
V
K
S
V
W
V
N
I
K
---------------
26
PsiBlast_CBE
84.46
32%
-92
- C2 -
4QET
3
?
B:
[20-489]
---
I
K
M
F
I
N
G
E
F
V
S
-
A
-
I
-
G
G
K
T
F
E
T
Y
N
P
A
-
T
E
D
V
L
A
V
V
C
E
A
Q
E
E
D
I
D
A
A
V
K
A
A
R
S
A
F
---
E
---
S
GP
W
A
E
M
T
T
A
E
R
A
H
L
I
Y
K
L
A
D
L
I
E
E
H
R
E
E
L
A
Q
L
E
A
L
D
N
G
K
P
Y
Q
V
A
-
L
-
D
D
D
I
S
A
T
V
E
N
Y
R
Y
Y
A
-------
G
W
T
T
K
I
I
G
Q
T
I
P
I
S
K
D
Y
L
N
Y
T
R
H
E
P
V
G
V
V
G
Q
I
I
P
W
N
F
P
L
V
M
S
S
W
K
M
G
A
A
L
A
T
G
C
T
I
V
L
K
P
A
E
Q
T
P
L
S
L
L
Y
A
A
K
L
F
K
E
A
G
F
P
N
G
V
V
N
F
V
P
G
F
D
-
P
-
E
A
G
A
A
I
V
N
H
H
-
D
I
D
K
V
A
F
T
G
S
T
V
T
G
K
Y
I
M
-
R
Q
S
-
A
E
M
I
K
H
V
T
L
E
L
G
G
K
S
P
N
I
I
L
E
D
A
D
L
E
E
A
I
N
G
A
F
Q
G
I
M
Y
-
N
H
G
Q
N
C
S
A
G
S
-
R
V
F
V
H
R
K
H
Y
E
T
V
V
D
A
L
V
K
M
A
N
N
V
K
L
G
A
G
M
E
K
E
T
E
M
G
P
L
V
S
K
K
Q
Q
E
R
V
L
N
Y
I
E
Q
G
K
K
E
G
A
T
V
A
A
G
G
E
----
R
A
L
E
K
G
Y
F
V
K
P
T
V
F
T
D
V
T
D
D
M
T
I
V
K
E
E
I
F
G
P
V
V
V
V
L
P
F
D
S
T
E
E
V
I
E
R
A
N
N
S
S
Y
G
L
A
A
G
V
W
T
Q
N
I
K
T
G
H
Q
V
A
N
K
L
K
A
G
T
V
W
I
N
-
D
Y
N
L
E
N
A
A
A
P
F
G
G
Y
K
Q
S
G
I
G
R
E
L
G
S
Y
A
L
D
N
---
Y
T
E
V
K
S
V
W
V
N
I
K
---------------
11
PsiBlast_PDB
84.40
31%
-94
- C2 -
5AC2
4
?
A:
[34-501]
-------------------
S
G
K
K
F
P
V
F
N
P
A
-
T
E
E
E
L
C
Q
V
E
E
G
D
K
E
D
V
D
K
A
V
K
A
A
R
Q
A
F
QIG
S
---
P
--
W
R
T
M
D
A
S
E
R
G
R
L
L
Y
K
L
A
D
L
I
E
R
D
R
L
L
L
A
T
M
E
S
M
N
G
G
K
L
Y
S
N
A
Y
L
-
N
D
-
L
A
G
C
I
K
T
L
R
Y
C
A
G
W
A
D
K
I
Q
G
R
-
T
I
P
I
D
G
N
F
F
T
Y
T
R
H
------
E
P
I
G
V
C
G
Q
I
I
P
W
N
F
P
L
V
M
L
I
W
K
I
G
P
A
L
S
C
G
N
T
V
V
V
K
P
A
E
Q
T
P
L
T
A
L
H
V
A
S
L
I
K
E
A
G
F
P
P
G
V
V
N
I
V
P
G
-
Y
-
G
-
P
T
A
G
A
A
I
S
S
H
M
D
I
D
K
V
A
F
T
G
S
T
E
V
G
K
L
I
K
E
A
A
G
-
K
S
N
L
K
R
V
T
L
E
L
G
G
K
S
P
C
I
V
L
A
D
A
D
L
D
N
A
V
E
-
F
A
H
H
G
V
F
Y
H
Q
G
Q
C
C
I
A
A
S
-
R
I
F
V
E
E
S
I
Y
D
E
F
V
R
R
S
V
E
R
A
K
K
Y
I
L
G
N
P
L
T
P
G
V
T
Q
G
P
Q
I
D
K
E
Q
Y
D
K
I
L
D
L
I
E
S
G
K
K
E
G
A
K
L
E
C
G
G
G
P
W
----
G
N
K
G
Y
F
V
Q
P
T
V
F
S
N
V
T
D
E
M
R
I
A
K
E
E
I
F
G
P
V
Q
Q
I
M
K
F
K
S
L
D
D
V
I
K
R
A
N
N
T
F
Y
G
L
S
A
G
V
F
T
K
D
I
D
K
A
I
T
I
S
S
A
L
Q
A
G
T
V
W
V
N
C
-
Y
G
V
V
S
A
Q
C
P
F
G
G
F
K
M
S
--
G
-
N
G
R
E
L
G
E
Y
G
F
H
E
Y
T
E
V
K
T
V
T
V
K
I
S
Q
K
N
S
-----------
29
PsiBlast_CBE
84.31
31%
-95
- C2 -
4PT3
4
?
B:
[20-489]
---
I
K
M
F
I
N
G
E
F
V
S
-
A
-
I
-
G
G
K
T
F
E
T
Y
N
P
A
-
T
E
D
V
L
A
V
V
C
E
A
Q
E
E
D
I
D
A
A
V
K
A
A
R
S
A
F
---
E
---
S
GP
W
A
E
M
T
T
A
E
R
A
H
L
I
Y
K
L
A
D
L
I
E
E
H
R
E
E
L
A
Q
L
E
A
L
D
N
G
K
P
Y
Q
V
A
-
L
-
D
D
D
I
S
A
T
V
E
N
Y
R
Y
Y
A
-------
G
W
T
T
K
I
I
G
Q
T
I
P
I
S
K
D
Y
L
N
Y
T
R
H
E
P
V
G
V
V
G
Q
I
I
P
W
N
F
P
L
V
M
S
S
W
K
M
G
A
A
L
A
T
G
C
T
I
V
L
K
P
A
E
Q
T
P
L
S
L
L
Y
A
A
K
L
F
K
E
A
G
F
P
N
G
V
V
N
F
V
P
G
F
G
-
P
-
E
A
G
A
A
I
V
N
H
H
-
D
I
D
K
V
A
F
T
G
S
T
V
T
G
K
Y
I
M
-
R
Q
S
-
A
E
M
I
K
H
V
T
L
E
L
G
G
K
S
P
N
I
I
L
E
D
A
D
L
E
E
A
I
N
G
A
F
Q
G
I
M
Y
-
N
H
G
Q
N
C
S
A
G
S
-
R
V
F
V
H
R
K
H
Y
E
T
V
V
D
A
L
V
K
M
A
N
N
V
K
L
G
A
G
M
E
K
E
T
E
M
G
P
L
V
S
K
K
Q
Q
E
R
V
L
N
Y
I
E
Q
G
K
K
E
G
A
T
V
A
A
G
G
E
----
R
A
L
E
K
G
Y
F
V
K
P
T
V
F
T
D
V
T
D
D
M
T
I
V
K
E
E
I
F
G
P
V
V
V
V
L
P
F
D
S
T
E
E
V
I
E
R
A
N
N
S
S
Y
G
L
A
A
G
V
W
T
Q
N
I
K
T
G
H
Q
V
A
N
K
L
K
A
G
T
V
W
I
N
-
D
Y
N
L
E
N
A
A
A
P
F
G
G
Y
K
Q
S
G
I
G
R
E
L
G
S
Y
A
L
D
N
---
Y
T
E
V
K
S
V
W
V
N
I
K
---------------
4
PsiBlast_PDB
84.29
32%
-96
- C2 -
4QET
3
?
A:
[20-489]
---
I
K
M
F
I
N
G
E
F
V
S
-
A
-
I
-
G
G
K
T
F
E
T
Y
N
P
A
-
T
E
D
V
L
A
V
V
C
E
A
Q
E
E
D
I
D
A
A
V
K
A
A
R
S
A
F
---
E
---
S
GP
W
A
E
M
T
T
A
E
R
A
H
L
I
Y
K
L
A
D
L
I
E
E
H
R
E
E
L
A
Q
L
E
A
L
D
N
G
K
P
Y
Q
V
A
-
L
-
D
D
D
I
S
A
T
V
E
N
Y
R
Y
Y
A
-------
G
W
T
T
K
I
I
G
Q
T
I
P
I
S
K
D
Y
L
N
Y
T
R
H
E
P
V
G
V
V
G
Q
I
I
P
W
N
F
P
L
V
M
S
S
W
K
M
G
A
A
L
A
T
G
C
T
I
V
L
K
P
A
E
Q
T
P
L
S
L
L
Y
A
A
K
L
F
K
E
A
G
F
P
N
G
V
V
N
F
V
P
G
F
D
-
P
-
E
A
G
A
A
I
V
N
H
H
-
D
I
D
K
V
A
F
T
G
S
T
V
T
G
K
Y
I
M
-
R
Q
S
-
A
E
M
I
K
H
V
T
L
E
L
G
G
K
S
P
N
I
I
L
E
D
A
D
L
E
E
A
I
N
G
A
F
Q
G
I
M
Y
-
N
H
G
Q
N
C
S
A
G
S
-
R
V
F
V
H
R
K
H
Y
E
T
V
V
D
A
L
V
K
M
A
N
N
V
K
L
G
A
G
M
E
K
E
T
E
M
G
P
L
V
S
K
K
Q
Q
E
R
V
L
N
Y
I
E
Q
G
K
K
E
G
A
T
V
A
A
G
G
E
----
R
A
L
E
K
G
Y
F
V
K
P
T
V
F
T
D
V
T
D
D
M
T
I
V
K
E
E
I
F
G
P
V
V
V
V
L
P
F
D
S
T
E
E
V
I
E
R
A
N
N
S
S
Y
G
L
A
A
G
V
W
T
Q
N
I
K
T
G
H
Q
V
A
N
K
L
K
A
G
T
V
W
I
N
-
D
Y
N
L
E
N
A
A
A
P
F
G
G
Y
K
Q
S
G
I
G
R
E
L
G
S
Y
A
L
D
N
---
Y
T
E
V
K
S
V
W
V
N
I
K
---------------
62
PsiBlast_CBE
84.26
32%
-95
- C2 -
4O6R
6
?
A:
[14-482]
------
F
I
D
G
R
F
V
D
A
V
-
D
-
R
G
-
T
I
D
V
L
N
P
H
-
D
G
S
V
I
T
K
I
A
A
A
T
A
A
D
V
D
L
A
V
D
A
A
T
R
A
F
---
P
---
A
--
W
S
A
M
P
A
A
E
R
G
R
L
L
L
R
L
A
D
A
I
E
A
N
T
E
A
L
A
Q
L
E
S
L
D
T
G
H
P
I
R
D
S
R
A
-
L
D
-
V
P
R
T
A
A
C
F
R
Y
F
G
G
M
A
D
K
L
Q
G
S
V
I
-
P
V
D
T
G
F
L
N
Y
V
Q
R
------
A
P
I
G
V
V
G
Q
I
V
P
W
N
F
P
L
M
F
T
S
W
K
M
G
P
A
L
A
A
G
N
T
V
V
L
K
P
S
E
I
T
P
L
S
T
L
R
I
V
E
L
M
A
E
V
G
F
P
A
G
V
V
N
I
V
P
G
Y
G
-
H
-
T
A
G
Q
R
L
A
E
H
P
-
G
V
G
K
I
A
F
T
G
S
T
A
T
G
R
R
I
V
-
E
A
S
-
Q
G
N
L
K
R
V
Q
L
E
L
G
G
K
G
A
N
I
V
F
D
D
A
N
L
D
A
A
I
N
-
G
A
A
W
A
I
F
H
N
Q
G
Q
A
C
I
A
G
S
R
L
V
-
L
H
E
R
I
A
D
A
F
L
E
R
F
V
A
L
A
S
S
I
R
I
G
N
P
L
D
P
N
T
E
M
G
P
L
T
S
K
Q
H
L
D
R
V
L
S
Y
V
D
V
A
R
E
Q
G
G
R
V
L
T
G
G
S
A
P
Q
D
P
A
L
A
N
G
Y
Y
V
R
P
T
I
V
E
A
K
H
A
T
D
R
V
A
Q
E
E
V
F
G
P
F
V
T
V
L
R
F
G
S
D
D
E
A
L
A
I
A
N
A
T
E
Y
G
L
G
S
G
L
W
T
N
D
L
S
R
A
H
R
M
A
A
R
I
D
A
G
M
C
W
I
N
C
Y
K
R
V
N
P
G
-
S
P
F
G
G
V
G
K
S
G
Y
G
---
R
E
M
G
F
E
A
M
H
D
Y
T
E
A
R
S
V
W
V
N
V
D
G
N
V
P
P
H
F
K
R
------