@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0140: (2015-12-23 )
MLDANLKTQLKAYLEKVSQPFEIVASLDDSDKSRELLGLLQDIVGLTDKITLKTDGSDARKPSFSLNRPGADIGLRFAGIPMGHEFTSLVLALLQVGGHPSKLDADVIEQVKGIEGTFEFETYFSLSCQNCPDVVQALNLMAVLNPNIRHVAIDGALFQDEVEARQIMSVPSIYLNGEVFGQGRMGVEEILAKIDTGAAARDAEKLTARDAFDVLVVGGGPAGAAAAIYAARKGIRTGVAAERFGGQVLDTMAIENFISVQETEGPKLARALEEHVRHYEVDIMNLQRASKLVPAKNAGELHEVRFESGGSLKAKTLILATGARWREMGVPGEQEYKAKGVCFCPHCDGPLFKGKRVAVIGGGNSGVEAAIDLAGIVAHVTLLEFDSKLRADAVLQRKLYSLPNVEVITSALTSEVKGDGQKVTGLVYKDRNSEEFKSIELEGIFVQIGLLPNTEWLKGSVELSPRGEIIVDARGETSLPGIFAAGDVTTVPYKQIVIAVGEGAKASLSAFDHLIRTSAPE
Atome Classification :
(20 SA)
.........10........20........30........40........50....-.--.-..60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460........470.......480.......490.........500.......510.......520
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MLD
A
N
L
K
T
Q
L
K
A
Y
L
E
K
VS
Q
P
F
E
I
V
ASLDDS
D
K
S
R
E
L
L
G
L
L
Q
D
I
VGLT
D
K
I
T
L
KTD-G--S-DARKPSFSLNRPGAD
I
G
L
R
F
AGIPMG
H
E
F
T
S
L
V
L
A
L
L
QVGGHPSKL
D
A
D
V
I
E
Q
V
KGI
E
G
T
F
E
F
E
T
Y
F
SLSCQN
C
P
D
V
V
Q
A
L
N
L
M
A
VLNPN
I
R
H
V
AIDG
A
L
F
Q
D
E
V
E
A
R
Q
I
MSV
P
S
I
Y
LN
G
E
V
FGQGRM
G
V
E
E
I
L
A
KIDTGAAAR
D
A
E
K
L
TARD
A
F
D
V
L
V
VGGGP
A
G
A
A
A
A
I
Y
A
A
R
K
GIRTG
V
A
A
E
R
FGG
Q
V
L
D
T
M
A
I
E
N
F
I
S
VQETE
G
P
K
L
A
R
A
L
E
E
H
V
R
H
Y
E
V
D
I
M
N
L
Q
R
A
S
KLVPAKNAGE
L
H
E
V
R
FESGGS
L
K
A
K
T
L
I
L
ATGA
R
W
REMGVPG
E
Q
EYKAKG
V
C
F
CPHCDGPLFKG
K
R
V
A
V
I
GGGNS
G
V
E
A
A
I
D
L
A
G
I
V
A
H
V
T
L
L
E
F
D
S
K
L
R
A
D
A
V
L
Q
R
K
L
YSLP
N
V
E
V
I
T
S
A
L
T
S
E
VKGDG
Q
K
V
T
G
L
V
Y
KDR
N
S
E
E
F
K
S
I
E
L
E
G
I
F
V
Q
I
GLLP
N
T
E
W
LKG
S
-
V
E
LSPRG
E
I
I
V
DARGETSLP
G
I
F
AAG
D
V
TT--VP
Y
K
Q
I
V
I
A
VGEGA
K
A
S
L
S
A
F
D
H
L
I
RTSAPE
1
PsiBlast_PDB
89.68
66%
-110
- C2 -
4YKF
19
?
A:
[1-518]
M
L
D
T
N
M
K
T
Q
L
K
A
Y
L
E
K
L
T
K
P
V
E
L
I
A
T
L
D
D
S
A
K
S
A
E
I
K
E
L
L
A
E
I
A
E
L
S
D
K
V
T
F
K
E
D
-
N
--
S
L
P
V
R
K
P
S
F
L
I
T
N
P
G
S
N
Q
G
P
R
F
A
G
S
P
L
G
H
E
F
T
S
L
V
L
A
L
L
W
T
G
G
H
P
S
K
E
A
Q
S
L
L
E
Q
I
R
H
I
D
G
D
F
E
F
E
T
Y
Y
S
L
S
C
H
N
C
P
D
V
V
Q
A
L
N
L
M
S
V
L
N
P
R
I
K
H
T
A
I
D
G
G
T
F
Q
N
E
I
T
D
R
N
V
M
G
V
P
A
V
F
V
N
G
K
E
F
G
Q
G
R
M
T
L
T
E
I
V
A
K
I
D
T
G
A
E
K
R
A
A
E
E
L
N
K
R
D
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
I
Y
S
A
R
K
G
I
R
T
G
L
M
G
E
R
F
G
G
Q
I
L
D
T
V
D
I
E
N
Y
I
S
V
P
K
T
E
G
Q
K
L
A
G
A
L
K
V
H
V
D
E
Y
D
V
D
V
I
D
S
Q
S
A
S
K
L
I
P
A
A
V
E
G
G
L
H
Q
I
E
T
A
S
G
A
V
L
K
A
R
S
I
I
V
A
T
G
A
K
W
R
N
M
N
V
P
G
E
D
Q
Y
R
T
K
G
V
T
Y
C
P
H
C
D
G
P
L
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
Q
V
L
Q
D
K
L
R
S
L
K
N
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
G
S
K
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
N
I
E
L
A
G
I
F
V
Q
I
G
L
L
P
N
T
N
W
L
E
G
A
-
V
E
R
N
R
M
G
E
I
I
I
D
A
K
C
E
T
N
V
K
G
V
F
A
A
G
D
C
T
T
--
V
P
Y
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
T
K
T
A
-
3
PsiBlast_PDB
89.24
66%
-110
- C2 -
4YKG
20
?
A:
[1-518]
M
L
D
T
N
M
K
T
Q
L
K
A
Y
L
E
K
L
T
K
P
V
E
L
I
A
T
L
D
D
S
A
K
S
A
E
I
K
E
L
L
A
E
I
A
E
L
S
D
K
V
T
F
K
E
D
-
N
--
S
L
P
V
R
K
P
S
F
L
I
T
N
P
G
S
N
Q
G
P
R
F
A
G
S
P
L
G
H
E
F
T
S
L
V
L
A
L
L
W
T
G
G
H
P
S
K
E
A
Q
S
L
L
E
Q
I
R
H
I
D
G
D
F
E
F
E
T
Y
Y
S
L
S
C
H
N
C
P
D
V
V
Q
A
L
N
L
M
S
V
L
N
P
R
I
K
H
T
A
I
D
G
G
T
F
Q
N
E
I
T
D
R
N
V
M
G
V
P
A
V
F
V
N
G
K
E
F
G
Q
G
R
M
T
L
T
E
I
V
A
K
I
D
T
G
A
E
K
R
A
A
E
E
L
N
K
R
D
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
I
Y
S
A
R
K
G
I
R
T
G
L
M
G
E
R
F
G
G
Q
I
L
D
T
V
D
I
E
N
Y
I
S
V
P
K
T
E
G
Q
K
L
A
G
A
L
K
V
H
V
D
E
Y
D
V
D
V
I
D
S
Q
S
A
S
K
L
I
P
A
A
V
E
G
G
L
H
Q
I
E
T
A
S
G
A
V
L
K
A
R
S
I
I
V
A
T
G
A
K
W
R
N
M
N
V
P
G
E
D
Q
Y
R
T
K
G
V
T
Y
-
P
H
C
D
G
P
L
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
Q
V
L
Q
D
K
L
R
S
L
K
N
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
G
S
K
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
N
I
E
L
A
G
I
F
V
Q
I
G
L
L
P
N
T
N
W
L
E
G
A
-
V
E
R
N
R
M
G
E
I
I
I
D
A
K
C
E
T
N
V
K
G
V
F
A
A
G
D
C
T
T
--
V
P
Y
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
T
K
T
A
-
69
HHSearch
87.73
66%
-101
- C2 -
1HYU
4
AHPF_SALTY
A:
[1-519]
M
L
D
T
N
M
K
T
Q
L
R
A
Y
L
E
K
L
T
K
P
V
E
L
I
A
T
L
D
D
S
A
K
S
A
E
I
K
E
L
L
A
E
I
A
E
L
S
D
K
V
T
F
K
E
D
-
N
TL
P
-
V
-
R
K
P
S
F
L
I
T
N
P
G
S
Q
Q
G
P
R
F
A
G
S
P
L
G
H
E
F
T
S
L
V
L
A
L
L
W
T
G
G
H
P
S
K
E
A
Q
S
L
L
E
Q
I
R
D
I
D
G
D
F
E
F
E
T
Y
Y
S
L
S
C
H
N
C
P
D
V
V
Q
A
L
N
L
M
A
V
L
N
P
R
I
K
H
T
A
I
D
G
G
T
F
Q
N
E
I
T
E
R
N
V
M
G
V
P
A
V
F
V
N
G
K
E
F
G
Q
G
R
M
T
L
T
E
I
V
A
K
V
D
T
G
A
E
K
R
A
A
E
A
L
N
K
R
D
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
V
Y
S
A
R
K
G
I
R
T
G
L
M
G
E
R
F
G
G
Q
V
L
D
T
V
D
I
E
N
Y
I
S
V
P
K
T
E
G
Q
K
L
A
G
A
L
K
A
H
V
S
D
Y
D
V
D
V
I
D
S
Q
S
A
S
K
L
V
P
A
A
T
E
G
G
L
H
Q
I
E
T
A
S
G
A
V
L
K
A
R
S
I
I
I
A
T
G
A
K
W
R
N
M
N
V
P
G
E
D
Q
Y
R
T
K
G
V
T
Y
C
P
H
C
D
G
P
L
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
Q
V
L
Q
D
K
V
R
S
L
K
N
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
G
S
K
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
S
V
A
L
A
G
I
F
V
Q
I
G
L
L
P
N
T
H
W
L
E
G
A
-
L
E
R
N
R
M
G
E
I
I
I
D
A
K
C
E
T
S
V
K
G
V
F
A
A
G
D
C
T
T
--
V
P
Y
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
T
K
I
A
-
2
PsiBlast_PDB
87.66
65%
-101
- C2 -
1HYU
4
AHPF_SALTY
A:
[1-518]
M
L
D
T
N
M
K
T
Q
L
R
A
Y
L
E
K
L
T
K
P
V
E
L
I
A
T
L
D
D
S
A
K
S
A
E
I
K
E
L
L
A
E
I
A
E
L
S
D
K
V
T
F
K
E
D
-
N
--
T
L
P
V
R
K
P
S
F
L
I
T
N
P
G
S
Q
Q
G
P
R
F
A
G
S
P
L
G
H
E
F
T
S
L
V
L
A
L
L
W
T
G
G
H
P
S
K
E
A
Q
S
L
L
E
Q
I
R
D
I
D
G
D
F
E
F
E
T
Y
Y
S
L
S
C
H
N
C
P
D
V
V
Q
A
L
N
L
M
A
V
L
N
P
R
I
K
H
T
A
I
D
G
G
T
F
Q
N
E
I
T
E
R
N
V
M
G
V
P
A
V
F
V
N
G
K
E
F
G
Q
G
R
M
T
L
T
E
I
V
A
K
V
D
T
G
A
E
K
R
A
A
E
A
L
N
K
R
D
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
V
Y
S
A
R
K
G
I
R
T
G
L
M
G
E
R
F
G
G
Q
V
L
D
T
V
D
I
E
N
Y
I
S
V
P
K
T
E
G
Q
K
L
A
G
A
L
K
A
H
V
S
D
Y
D
V
D
V
I
D
S
Q
S
A
S
K
L
V
P
A
A
T
E
G
G
L
H
Q
I
E
T
A
S
G
A
V
L
K
A
R
S
I
I
I
A
T
G
A
K
W
R
N
M
N
V
P
G
E
D
Q
Y
R
T
K
G
V
T
Y
C
P
H
C
D
G
P
L
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
Q
V
L
Q
D
K
V
R
S
L
K
N
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
G
S
K
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
S
V
A
L
A
G
I
F
V
Q
I
G
L
L
P
N
T
H
W
L
E
G
A
-
L
E
R
N
R
M
G
E
I
I
I
D
A
K
C
E
T
S
V
K
G
V
F
A
A
G
D
C
T
T
--
V
P
Y
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
T
K
I
A
-
60
Fugue
87.43
65%
-101
- C2 -
1HYU
4
AHPF_SALTY
A:
[1-521]
M
L
D
T
N
M
K
T
Q
L
R
A
Y
L
E
K
L
T
K
P
V
E
L
I
A
T
L
D
D
S
A
K
S
A
E
I
K
E
L
L
A
E
I
A
E
L
S
D
K
V
T
F
K
E
D
N
T
--
L
-
P
V
R
K
P
S
F
L
I
T
N
P
G
S
Q
Q
G
P
R
F
A
G
S
P
L
G
H
E
F
T
S
L
V
L
A
L
L
W
T
G
G
H
P
S
K
E
A
Q
S
L
L
E
Q
I
R
D
I
D
G
D
F
E
F
E
T
Y
Y
S
L
S
C
H
N
C
P
D
V
V
Q
A
L
N
L
M
A
V
L
N
P
R
I
K
H
T
A
I
D
G
G
T
F
Q
N
E
I
T
E
R
N
V
M
G
V
P
A
V
F
V
N
G
K
E
F
G
Q
G
R
M
T
L
T
E
I
V
A
K
V
D
T
G
A
E
K
R
A
A
E
A
L
N
K
R
D
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
V
Y
S
A
R
K
G
I
R
T
G
L
M
G
E
R
F
G
G
Q
V
L
D
T
V
D
I
E
N
Y
I
S
V
P
K
T
E
G
Q
K
L
A
G
A
L
K
A
H
V
S
D
Y
D
V
D
V
I
D
S
Q
S
A
S
K
L
V
P
A
A
T
E
G
G
L
H
Q
I
E
T
A
S
G
A
V
L
K
A
R
S
I
I
I
A
T
G
A
K
W
R
N
M
N
V
P
G
E
D
Q
Y
R
T
K
G
V
T
Y
C
P
H
C
D
G
P
L
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
Q
V
L
Q
D
K
V
R
S
L
K
N
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
G
S
K
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
S
V
A
L
A
G
I
F
V
Q
I
G
L
L
P
N
T
H
W
L
E
G
A
-
L
E
R
N
R
M
G
E
I
I
I
D
A
K
C
E
T
S
V
K
G
V
F
A
A
G
D
C
T
T
--
V
P
Y
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
T
K
I
A
-
71
HHSearch
62.68
69%
-97
- C2 -
1FL2
5
AHPF_ECOLI
A:
[1-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
I
Y
S
A
R
K
G
I
R
T
G
L
M
G
E
R
F
G
G
Q
I
L
D
T
V
D
I
E
N
Y
I
S
V
P
K
T
E
G
Q
K
L
A
G
A
L
K
V
H
V
D
E
Y
D
V
D
V
I
D
S
Q
S
A
S
K
L
I
P
A
A
V
E
G
G
L
H
Q
I
E
T
A
S
G
A
V
L
K
A
R
S
I
I
V
A
T
G
A
K
W
R
N
M
N
V
P
G
E
D
Q
Y
R
T
K
G
V
T
Y
C
P
H
C
D
G
P
L
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
Q
V
L
Q
D
K
L
R
S
L
K
N
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
G
S
K
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
N
I
E
L
A
G
I
F
V
Q
I
G
L
L
P
N
T
N
W
L
E
G
A
-
V
E
R
N
R
M
G
E
I
I
I
D
A
K
C
E
T
N
V
K
G
V
F
A
A
G
D
C
T
T
--
V
P
Y
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
T
K
T
A
-
4
PsiBlast_PDB
62.68
69%
-97
- C2 -
1FL2
5
AHPF_ECOLI
A:
[1-307]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
Y
D
V
L
I
V
G
S
G
P
A
G
A
A
A
A
I
Y
S
A
R
K
G
I
R
T
G
L
M
G
E
R
F
G
G
Q
I
L
D
T
V
D
I
E
N
Y
I
S
V
P
K
T
E
G
Q
K
L
A
G
A
L
K
V
H
V
D
E
Y
D
V
D
V
I
D
S
Q
S
A
S
K
L
I
P
A
A
V
E
G
G
L
H
Q
I
E
T
A
S
G
A
V
L
K
A
R
S
I
I
V
A
T
G
A
K
W
R
N
M
N
V
P
G
E
D
Q
Y
R
T
K
G
V
T
Y
C
P
H
C
D
G
P
L
F
K
G
K
R
V
A
V
I
G
G
G
N
S
G
V
E
A
A
I
D
L
A
G
I
V
E
H
V
T
L
L
E
F
A
P
E
M
K
A
D
Q
V
L
Q
D
K
L
R
S
L
K
N
V
D
I
I
L
N
A
Q
T
T
E
V
K
G
D
G
S
K
V
V
G
L
E
Y
R
D
R
V
S
G
D
I
H
N
I
E
L
A
G
I
F
V
Q
I
G
L
L
P
N
T
N
W
L
E
G
A
-
V
E
R
N
R
M
G
E
I
I
I
D
A
K
C
E
T
N
V
K
G
V
F
A
A
G
D
C
T
T
--
V
P
Y
K
Q
I
I
I
A
T
G
E
G
A
K
A
S
L
S
A
F
D
Y
L
I
R
T
K
T
A
-
5
PsiBlast_PDB
56.64
61%
-125
* C4 *
1ZYN
-
AHPF_SALTY
A:
[1-196]
M
L
D
T
N
M
K
T
Q
L
R
A
Y
L
E
K
L
T
K
P
V
E
L
I
A
T
L
D
D
S
A
K
S
A
E
I
K
E
L
L
A
E
I
A
E
L
S
D
K
V
T
F
K
E
D
-
N
--
T
L
P
V
R
K
P
S
F
L
I
T
N
P
G
S
Q
Q
G
P
R
F
A
G
S
P
L
G
H
E
F
T
S
L
V
L
A
L
L
W
T
G
G
H
P
S
K
E
A
Q
S
L
L
E
Q
I
R
D
I
D
G
D
F
E
F
E
T
Y
Y
S
L
S
C
H
N
C
P
D
V
V
Q
A
L
N
L
M
A
V
L
N
P
R
I
K
H
T
A
I
D
G
G
T
F
Q
N
E
I
T
E
R
N
V
M
G
V
P
A
V
F
V
N
G
K
E
F
G
Q
G
R
M
T
L
T
E
I
V
A
K
V
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_PDB
56.07
61%
-127
- C4 -
1ZYP
-
AHPF_SALTY
A:
[1-196]
M
L
D
T
N
M
K
T
Q
L
R
A
Y
L
E
K
L
T
K
P
V
E
L
I
A
T
L
D
D
S
A
K
S
A
E
I
K
E
L
L
A
E
I
A
E
L
S
D
K
V
T
F
K
E
D
-
N
--
T
L
P
V
R
K
P
S
F
L
I
T
N
P
G
S
Q
Q
G
P
R
F
A
G
S
P
L
G
H
E
F
T
S
L
V
L
A
L
L
W
T
G
G
H
P
S
K
E
A
Q
S
L
L
E
Q
I
R
D
I
D
G
D
F
E
F
E
T
Y
Y
S
L
S
C
H
N
C
P
D
V
V
Q
A
L
N
L
M
A
V
L
N
P
R
I
K
H
T
A
I
D
G
G
T
F
Q
N
E
I
T
E
R
N
V
M
G
V
P
A
V
F
V
N
G
K
E
F
G
Q
G
R
M
T
L
T
E
I
V
A
K
V
D
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
29
PsiBlast_CBE
52.41
34%
-92
- C2 -
3F8D
3
?
C:
[14-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
G
E
T
P
G
G
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
L
-
L
D
I
V
E
K
I
---
E
N
---
E
F
V
V
K
T
K
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
A
D
A
P
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
K
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
-
K
V
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
AW
L
G
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
T
E
K
----
30
PsiBlast_CBE
52.04
34%
-90
- C2 -
3F8D
5
?
B:
[14-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
G
E
T
P
G
G
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
L
-
L
D
I
V
E
K
I
---
E
N
R
-
D
E
F
V
V
K
T
K
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
A
D
A
P
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
K
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
-
K
V
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
AW
L
G
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
T
E
K
----
28
PsiBlast_CBE
51.88
34%
-89
- C2 -
3F8D
3
?
D:
[14-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
G
E
T
P
G
G
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
L
-
L
D
I
V
E
K
I
---
E
N
R
G
D
E
F
V
V
K
T
K
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
A
D
A
P
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
K
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
-
K
V
V
K
Q
V
V
V
E
N
L
K
--------
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
AW
L
G
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
T
E
-----
10
PsiBlast_PDB
51.41
34%
-90
- C2 -
3F8D
3
?
A:
[14-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
G
E
T
P
G
G
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
L
-
L
D
I
V
E
K
I
---
E
N
R
--
E
F
V
V
K
T
K
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
A
D
A
P
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
K
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
-
K
V
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
AW
L
G
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
T
E
K
----
27
PsiBlast_CBE
51.31
34%
-89
- C2 -
3F8P
4
?
B:
[14-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
G
E
T
P
G
G
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
L
-
L
D
I
V
E
K
I
---
E
----
E
F
V
V
K
T
K
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
C
D
A
P
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
K
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
-
K
V
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
AW
L
G
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
T
E
K
----
23
PsiBlast_CBE
51.17
34%
-91
- C2 -
3F8R
3
?
C:
[14-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
G
E
T
P
G
G
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
L
-
L
D
I
V
E
K
I
---
E
N
---
E
F
V
V
K
T
K
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
C
D
A
P
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
K
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
-
K
V
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
AW
L
G
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
T
E
K
----
25
PsiBlast_CBE
51.07
34%
-89
- C2 -
3F8P
2
?
D:
[14-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
G
E
T
P
G
G
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
L
-
L
D
I
V
E
K
I
---
E
N
R
G
D
E
F
V
V
K
T
K
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
C
D
A
P
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
K
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
-
K
V
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
AW
L
G
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
T
E
K
----
24
PsiBlast_CBE
50.90
34%
-86
- C2 -
3F8R
3
?
B:
[14-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
G
E
T
P
G
G
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
L
-
L
D
I
V
E
K
I
---
E
N
R
-
D
E
F
V
V
K
T
K
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
C
D
A
P
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
K
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
-
K
V
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
AW
L
G
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
T
E
K
----
26
PsiBlast_CBE
50.88
34%
-88
- C2 -
3F8P
1
?
C:
[14-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
G
E
T
P
G
G
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
L
-
L
D
I
V
E
K
I
---
E
N
---
E
F
V
V
K
T
K
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
C
D
A
P
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
K
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
-
K
V
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
AW
L
G
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
T
E
K
K
---
22
PsiBlast_CBE
50.84
34%
-88
- C2 -
3F8R
3
?
D:
[14-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
G
E
T
P
G
G
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
L
-
L
D
I
V
E
K
I
---
E
N
R
G
D
E
F
V
V
K
T
K
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
C
D
A
P
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
K
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
-
K
V
V
K
Q
V
V
V
E
N
L
K
--------
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
AW
L
G
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
T
E
-----
8
PsiBlast_PDB
50.83
34%
-90
- C2 -
3F8P
4
?
A:
[14-316]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
K
F
D
V
I
I
V
G
L
G
P
A
A
Y
G
A
A
L
Y
S
A
R
Y
M
L
K
T
L
V
I
G
E
T
P
G
G
Q
L
T
E
A
G
I
V
D
D
Y
L
G
L
I
E
I
Q
A
S
D
M
I
K
V
F
N
K
H
I
E
K
Y
E
V
P
V
L
-
L
D
I
V
E
K
I
---
E
N
---
E
F
V
V
K
T
K
R
K
G
E
F
K
A
D
S
V
I
L
G
I
G
V
K
R
R
K
L
G
V
P
G
E
Q
E
F
A
G
R
G
I
S
Y
C
S
V
C
D
A
P
L
F
K
N
R
V
V
A
V
I
G
G
G
D
S
A
L
E
G
A
E
I
L
S
S
Y
S
T
K
V
Y
L
I
H
R
R
D
T
F
K
A
Q
P
I
Y
V
E
T
V
K
K
K
P
N
V
E
F
V
L
N
S
V
V
K
E
I
K
G
D
-
K
V
V
K
Q
V
V
V
E
N
L
K
T
G
E
I
K
E
L
N
V
N
G
V
F
I
E
I
G
F
D
P
P
T
D
F
A
K
S
N
G
I
E
T
D
T
N
G
Y
I
K
V
D
E
W
M
R
T
S
V
P
G
V
F
A
A
G
D
C
T
S
AW
L
G
F
R
Q
V
I
T
A
V
A
Q
G
A
V
A
A
T
S
A
Y
R
Y
V
T
E
K
----