@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0148: (2015-12-23 )
MYEWLNALPKAELHLHLEGTLEPELLFALAERNRIALPWNDVETLRKAYAFNNLQEFLDLYYAGADVLRTEQDFYDLTWAYLQKCKAQNVVHVEPFFDPQTHTDRGIPFEVVLAGIRAALRDGEKLLGIRHGLILSFLRHLSEEQAQKTLDQALPFRDAFIAVGLDSSEVGHPPSKFQRVFDRARSEGFLTVAHAGEEGPPEYIWEALDLLKVERIDHGVRAFEDERLMRRLIDEQIPLTVCPLSNTKLCVFDDMSQHTILDMLERGVKVTVNSDDPAYFGGYVTENFHALQQSLGMTEEQARRLAQNSLDARLVK
Atome Classification :
(20 SA)
.........10........20........30........40....----....---50--..---.-......60---.-...-.....-70........80........90........100----------.------------...------------.--..-------------..110.......120.......130.......140--------.........150.....-.-.-160.......170.---..---..----.---.180.......190.......200........210.......220.......230.......240.......250..---.....260.......270.......280.......290.......300.......310....----------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
M
Y
E
W
L
N
ALPK
A
E
L
H
L
H
LEGTL
E
P
E
L
L
F
A
L
AER
N
R
I
ALPW
N
D
V
E
T
L
----
R
K
A
Y
---
A
---
F
N
---
N
-
L
Q
E
F
L
D
L
----
Y
-YAG-ADVLR-TE
Q
D
F
Y
D
L
T
W
A
Y
L
Q
K
CKAQ
N
V
V
H
VEPFFDPQ------------T------------HTD------------R--GI-------------
P
F
E
V
V
L
A
G
I
R
A
A
L
RD
G
E
K
L
L
G
I
R
H
G
L
I
L
S
F
L
R
H
----------
L
S
E
E
Q
A
Q
K
T
L
D
Q
ALPFR-
D
-
A
-
F
I
A
VGL
D
S
SEVGHP---
P
S
---
K
F
----
Q
---
R
V
F
D
R
ARSE
G
F
L
T
V
A
HAGEEG
P
P
-
E
Y
I
W
E
A
L
D
L
L
K
V
E
R
I
D
H
G
V
R
A
F
E
D
E
R
L
M
R
R
L
I
DEQI
P
L
T
V
C
PLSN
T
K
L
C
V
FDD---M
S
Q
H
T
I
L
D
M
L
ERG
V
K
V
T
VNSDDPAYF
G
G
Y
V
T
E
N
F
H
A
L
Q
Q
SLGM
T
E
E
Q
A
R
R
L
A
Q
NSLDARLVK----------------
25
HHSearch
99.64
100%
-95
- C3 -
3PAO
2
ADE_PSEAE
A:
[4-316]
-
Y
E
W
L
N
A
L
P
K
A
E
L
H
L
H
L
E
G
T
L
E
P
E
L
L
F
A
L
A
E
R
N
R
I
A
L
P
W
N
D
V
E
T
L
----
R
K
A
Y
---
A
---
F
N
---
N
-
L
Q
E
F
L
D
L
----
Y
-
Y
A
G
-
A
D
V
L
R
-
T
E
Q
D
F
Y
D
L
T
W
A
Y
L
Q
K
C
K
A
Q
N
V
V
H
V
E
P
F
F
D
P
Q
------------
T
------------
H
T
D
------------
R
--
G
I
-------------
P
F
E
V
V
L
A
G
I
R
A
A
L
R
D
G
E
K
L
L
G
I
R
H
G
L
I
L
S
F
L
R
H
----------
L
S
E
E
Q
A
Q
K
T
L
D
Q
A
L
P
F
R
-
D
-
A
-
F
I
A
V
G
L
D
S
S
E
V
G
H
P
---
P
S
---
K
F
----
Q
---
R
V
F
D
R
A
R
S
E
G
F
L
T
V
A
H
A
G
E
E
G
P
P
-
E
Y
I
W
E
A
L
D
L
L
K
V
E
R
I
D
H
G
V
R
A
F
E
D
E
R
L
M
R
R
L
I
D
E
Q
I
P
L
T
V
C
P
L
S
N
T
K
L
C
V
F
D
D
---
M
S
Q
H
T
I
L
D
M
L
E
R
G
V
K
V
T
V
N
S
D
D
P
A
Y
F
G
G
Y
V
T
E
N
F
H
A
L
Q
Q
S
L
G
M
T
E
E
Q
A
R
R
L
A
Q
N
S
L
D
A
R
L
------------------
3
PsiBlast_PDB
99.22
98%
-95
- C3 -
3PAO
2
ADE_PSEAE
A:
[4-316]
-
Y
E
W
L
N
A
L
P
K
A
E
L
H
L
H
L
E
G
T
L
E
P
E
L
L
F
A
L
A
E
R
N
R
I
A
L
P
W
N
D
V
E
T
L
----
R
K
A
Y
---
A
---
F
N
---
N
-
L
Q
E
F
L
D
L
----
Y
-
Y
A
G
-
A
D
V
L
R
-
T
E
Q
D
F
Y
D
L
T
W
A
Y
L
Q
K
C
K
A
Q
N
V
V
H
V
E
P
F
F
D
P
Q
------------
T
------------
H
T
D
------------
R
--
G
I
-------------
P
F
E
V
V
L
A
G
I
R
A
A
L
R
D
G
E
K
L
L
G
I
R
H
G
L
I
L
S
F
L
R
H
----------
L
S
E
E
Q
A
Q
K
T
L
D
Q
A
L
P
F
R
-
D
-
A
-
F
I
A
V
G
L
D
S
S
E
V
G
H
P
---
P
S
---
K
F
----
Q
---
R
V
F
D
R
A
R
S
E
G
F
L
T
V
A
H
A
G
E
E
G
P
P
-
E
Y
I
W
E
A
L
D
L
L
K
V
E
R
I
D
H
G
V
R
A
F
E
D
E
R
L
M
R
R
L
I
D
E
Q
I
P
L
T
V
C
P
L
S
N
T
K
L
C
V
F
D
D
---
M
S
Q
H
T
I
L
D
M
L
E
R
G
V
K
V
T
V
N
S
D
D
P
A
Y
F
G
G
Y
V
T
E
N
F
H
A
L
Q
Q
S
L
G
M
T
E
E
Q
A
R
R
L
A
Q
N
S
L
D
A
R
L
------------------
4
PsiBlast_PDB
99.06
98%
-97
- C3 -
3PBM
2
ADE_PSEAE
A:
[4-316]
-
Y
E
W
L
N
A
L
P
K
A
E
L
H
L
H
L
E
G
T
L
E
P
E
L
L
F
A
L
A
E
R
N
R
I
A
L
P
W
N
D
V
E
T
L
----
R
K
A
Y
---
A
---
F
N
---
N
-
L
Q
E
F
L
D
L
----
Y
-
Y
A
G
-
A
D
V
L
R
-
T
E
Q
D
F
Y
D
L
T
W
A
Y
L
Q
K
C
K
A
Q
N
V
V
H
V
E
P
F
F
D
P
Q
------------
T
------------
H
T
D
------------
R
--
G
I
-------------
P
F
E
V
V
L
A
G
I
R
A
A
L
R
D
G
E
K
L
L
G
I
R
H
G
L
I
L
S
F
L
R
H
----------
L
S
E
E
Q
A
Q
K
T
L
D
Q
A
L
P
F
R
-
D
-
A
-
F
I
A
V
G
L
D
S
S
E
V
G
H
P
---
P
S
---
K
F
----
Q
---
R
V
F
D
R
A
R
S
E
G
F
L
T
V
A
H
A
G
E
E
G
P
P
-
E
Y
I
W
E
A
L
D
L
L
K
V
E
R
I
D
H
G
V
R
A
F
E
D
E
R
L
M
R
R
L
I
D
E
Q
I
P
L
T
V
C
P
L
S
N
T
K
L
C
V
F
D
D
---
M
S
Q
H
T
I
L
D
M
L
E
R
G
V
K
V
T
V
N
S
D
D
P
A
Y
F
G
G
Y
V
T
E
N
F
H
A
L
Q
Q
S
L
G
M
T
E
E
Q
A
R
R
L
A
Q
N
S
L
D
A
R
L
------------------
1
PsiBlast_PDB
98.76
98%
-93
- C3 -
3OU8
1
ADE_PSEAE
A:
[4-316]
-
Y
E
W
L
N
A
L
P
K
A
E
L
H
L
H
L
E
G
T
L
E
P
E
L
L
F
A
L
A
E
R
N
R
I
A
L
P
W
N
D
V
E
T
L
----
R
K
A
Y
---
A
---
F
N
---
N
-
L
Q
E
F
L
D
L
----
Y
-
Y
A
G
-
A
D
V
L
R
-
T
E
Q
D
F
Y
D
L
T
W
A
Y
L
Q
K
C
K
A
Q
N
V
V
H
V
E
P
F
F
D
P
Q
------------
T
------------
H
T
D
------------
R
--
G
I
-------------
P
F
E
V
V
L
A
G
I
R
A
A
L
R
D
G
E
K
L
L
G
I
R
H
G
L
I
L
S
F
L
R
H
----------
L
S
E
E
Q
A
Q
K
T
L
D
Q
A
L
P
F
R
-
D
-
A
-
F
I
A
V
G
L
D
S
S
E
V
G
H
P
---
P
S
---
K
F
----
Q
---
R
V
F
D
R
A
R
S
E
G
F
L
T
V
A
H
A
G
E
E
G
P
P
-
E
Y
I
W
E
A
L
D
L
L
K
V
E
R
I
D
H
G
V
R
A
F
E
D
E
R
L
M
R
R
L
I
D
E
Q
I
P
L
T
V
C
P
L
S
N
T
K
L
C
V
F
D
D
---
M
S
Q
H
T
I
L
D
M
L
E
R
G
V
K
V
T
V
N
S
D
D
P
A
Y
F
G
G
Y
V
T
E
N
F
H
A
L
Q
Q
S
L
G
M
T
E
E
Q
A
R
R
L
A
Q
N
S
L
D
A
R
L
------------------
2
PsiBlast_PDB
98.75
98%
-96
- C3 -
3PAN
2
ADE_PSEAE
A:
[4-316]
-
Y
E
W
L
N
A
L
P
K
A
E
L
H
L
H
L
E
G
T
L
E
P
E
L
L
F
A
L
A
E
R
N
R
I
A
L
P
W
N
D
V
E
T
L
----
R
K
A
Y
---
A
---
F
N
---
N
-
L
Q
E
F
L
D
L
----
Y
-
Y
A
G
-
A
D
V
L
R
-
T
E
Q
D
F
Y
D
L
T
W
A
Y
L
Q
K
C
K
A
Q
N
V
V
H
V
E
P
F
F
D
P
Q
------------
T
------------
H
T
D
------------
R
--
G
I
-------------
P
F
E
V
V
L
A
G
I
R
A
A
L
R
D
G
E
K
L
L
G
I
R
H
G
L
I
L
S
F
L
R
H
----------
L
S
E
E
Q
A
Q
K
T
L
D
Q
A
L
P
F
R
-
D
-
A
-
F
I
A
V
G
L
D
S
S
E
V
G
H
P
---
P
S
---
K
F
----
Q
---
R
V
F
D
R
A
R
S
E
G
F
L
T
V
A
H
A
G
E
E
G
P
P
-
E
Y
I
W
E
A
L
D
L
L
K
V
E
R
I
D
H
G
V
R
A
F
E
D
E
R
L
M
R
R
L
I
D
E
Q
I
P
L
T
V
C
P
L
S
N
T
K
L
C
V
F
D
D
---
M
S
Q
H
T
I
L
D
M
L
E
R
G
V
K
V
T
V
N
S
D
D
P
A
Y
F
G
G
Y
V
T
E
N
F
H
A
L
Q
Q
S
L
G
M
T
E
E
Q
A
R
R
L
A
Q
N
S
L
D
A
R
L
------------------
27
HHSearch
83.51
52%
-88
- C3 -
3RYS
2
?
A:
[8-321]
--
T
T
S
T
A
P
P
V
A
E
L
H
L
H
I
E
G
T
L
Q
P
E
L
I
F
A
L
A
E
R
N
G
I
E
L
P
Y
E
D
I
E
E
L
----
R
E
K
Y
---
E
---
F
T
---
D
-
L
Q
S
F
L
D
L
----
Y
-
Y
A
N
-
M
A
V
L
Q
-
T
E
Q
D
F
T
D
M
T
R
A
Y
L
E
R
A
A
A
G
G
V
R
H
A
E
I
M
M
D
P
Q
------------
A
------------
H
T
S
------------
R
--
G
V
-------------
A
L
E
T
C
V
N
G
V
A
N
A
L
A
T
S
E
E
D
F
G
V
S
T
L
L
I
A
A
F
L
R
D
----------
M
S
E
D
S
A
L
E
V
L
D
Q
L
L
A
M
H
-
A
-
P
-
I
A
G
I
G
L
D
S
A
E
V
G
N
P
---
P
S
---
K
F
----
E
---
R
L
Y
Q
R
A
A
E
A
G
L
R
R
I
A
H
A
G
E
E
G
P
A
-
S
Y
I
T
E
A
L
D
V
L
H
V
E
R
I
D
H
G
I
R
C
M
E
D
T
D
V
V
Q
R
L
V
A
E
Q
V
P
L
T
V
C
P
L
S
N
V
R
L
R
A
V
D
K
---
L
A
D
H
P
L
P
E
M
L
A
I
G
L
N
V
C
V
N
S
D
D
P
A
Y
F
G
G
Y
V
D
D
N
F
E
Q
L
V
K
V
L
E
F
S
V
P
E
Q
A
T
L
A
A
N
S
I
R
S
S
F
A
S
----------------
5
PsiBlast_PDB
83.40
53%
-91
- C3 -
3RYS
2
?
A:
[11-315]
-----
T
A
P
P
V
A
E
L
H
L
H
I
E
G
T
L
Q
P
E
L
I
F
A
L
A
E
R
N
G
I
E
L
P
Y
E
D
I
E
E
L
----
R
E
K
Y
---
E
---
F
T
---
D
-
L
Q
S
F
L
D
L
----
Y
-
Y
A
N
-
M
A
V
L
Q
-
T
E
Q
D
F
T
D
M
T
R
A
Y
L
E
R
A
A
A
G
G
V
R
H
A
E
I
M
M
D
P
Q
------------
A
------------
H
T
S
------------
R
--
G
V
-------------
A
L
E
T
C
V
N
G
V
A
N
A
L
A
T
S
E
E
D
F
G
V
S
T
L
L
I
A
A
F
L
R
D
----------
M
S
E
D
S
A
L
E
V
L
D
Q
L
L
A
M
H
-
A
-
P
-
I
A
G
I
G
L
D
S
A
E
V
G
N
P
---
P
S
---
K
F
----
E
---
R
L
Y
Q
R
A
A
E
A
G
L
R
R
I
A
H
A
G
E
E
G
P
A
-
S
Y
I
T
E
A
L
D
V
L
H
V
E
R
I
D
H
G
I
R
C
M
E
D
T
D
V
V
Q
R
L
V
A
E
Q
V
P
L
T
V
C
P
L
S
N
V
R
L
R
A
V
D
K
---
L
A
D
H
P
L
P
E
M
L
A
I
G
L
N
V
C
V
N
S
D
D
P
A
Y
F
G
G
Y
V
D
D
N
F
E
Q
L
V
K
V
L
E
F
S
V
P
E
Q
A
T
L
A
A
N
S
I
R
S
S
F
A
S
----------------
21
PsiBlast_CBE
82.83
53%
-91
- C3 -
3RYS
2
?
B:
[12-315]
------
A
P
P
V
A
E
L
H
L
H
I
E
G
T
L
Q
P
E
L
I
F
A
L
A
E
R
N
G
I
E
L
P
Y
E
D
I
E
E
L
----
R
E
K
Y
---
E
---
F
T
---
D
-
L
Q
S
F
L
D
L
----
Y
-
Y
A
N
-
M
A
V
L
Q
-
T
E
Q
D
F
T
D
M
T
R
A
Y
L
E
R
A
A
A
G
G
V
R
H
A
E
I
M
M
D
P
Q
------------
A
------------
H
T
S
------------
R
--
G
V
-------------
A
L
E
T
C
V
N
G
V
A
N
A
L
A
T
S
E
E
D
F
G
V
S
T
L
L
I
A
A
F
L
R
D
----------
M
S
E
D
S
A
L
E
V
L
D
Q
L
L
A
M
H
-
A
-
P
-
I
A
G
I
G
L
D
S
A
E
V
G
N
P
---
P
S
---
K
F
----
E
---
R
L
Y
Q
R
A
A
E
A
G
L
R
R
I
A
H
A
G
E
E
G
P
A
-
S
Y
I
T
E
A
L
D
V
L
H
V
E
R
I
D
H
G
I
R
C
M
E
D
T
D
V
V
Q
R
L
V
A
E
Q
V
P
L
T
V
C
P
L
S
N
V
R
L
R
A
V
D
K
---
L
A
D
H
P
L
P
E
M
L
A
I
G
L
N
V
C
V
N
S
D
D
P
A
Y
F
G
G
Y
V
D
D
N
F
E
Q
L
V
K
V
L
E
F
S
V
P
E
Q
A
T
L
A
A
N
S
I
R
S
S
F
A
S
----------------
46
Fugue
74.68
27%
-83
- C3 -
1A4M
2
ADA_MOUSE
A:
[1-349]
--
T
P
A
F
N
K
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
F
G
K
K
R
G
I
A
L
P
A
D
T
V
E
E
L
----
R
N
I
I
---
G
MD
K
P
L
---
S
-
L
P
G
F
L
A
K
----
F
-
D
Y
Y
-
M
P
V
I
A
G
C
R
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
------------
L
LANSKVDPMPWN
Q
T
E
------------
G
--
D
V
-------------
T
P
D
D
V
V
D
L
V
N
Q
G
L
Q
E
G
E
Q
A
F
G
I
K
V
R
S
I
L
C
C
M
R
H
-----------
Q
P
S
W
S
L
E
V
L
E
L
C
K
K
Y
N
-
Q
-
K
T
V
V
A
M
D
L
A
G
D
E
T
I
E
G
---
S
S
LF
P
G
H
----
V
---
E
A
Y
E
G
A
V
K
N
G
I
H
R
T
V
H
A
G
E
V
G
S
P
-
E
V
V
R
E
A
V
D
I
L
K
T
E
R
V
G
H
G
Y
H
T
I
E
D
E
A
L
Y
N
R
L
L
K
E
N
M
H
F
E
V
C
P
W
S
S
Y
L
T
G
A
W
D
P
---
K
T
T
H
A
V
V
R
F
K
N
D
K
A
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
E
E
E
K
K
E
L
L
E
R
L
Y
R
E
Y
Q
18
PsiBlast_PDB
73.13
26%
-85
- C3 -
3T1G
5
ADA_MOUSE
A:
[11-336]
--------
P
K
V
E
L
H
V
H
L
S
G
A
I
K
P
E
T
I
L
Y
F
G
K
K
R
G
I
A
L
P
A
D
T
V
E
E
L
----
R
N
I
I
---
G
---
M
D
---
K
P
L
S
Q
P
G
T
L
A
K
W
D
Y
-
Y
M
P
-
V
-
I
A
G
-
C
R
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
LLANSKVDPMPW
N
------------
Q
T
E
------------
G
--
D
V
-------------
T
P
D
D
V
V
D
L
V
N
Q
G
L
H
E
G
E
Q
A
F
G
I
K
V
R
S
I
L
C
C
M
R
H
QPSW
S
L
E
V
L
E
L
C
K
K
Y
N
Q
K
T
V
-------------
V
A
M
D
L
I
G
D
E
T
I
E
G
---
S
S
---
L
F
----
P
G
H
V
E
A
Y
E
G
A
V
K
N
G
I
H
R
T
V
H
A
G
E
F
G
S
P
-
E
V
V
R
E
A
V
D
I
L
K
T
E
R
V
G
H
G
Y
H
T
I
E
D
E
A
L
Y
N
R
L
L
K
E
N
M
H
F
E
V
C
P
W
S
S
Y
L
T
G
A
W
D
P
---
K
T
T
H
A
V
V
R
F
K
N
D
K
A
N
Y
S
L
N
T
D
A
P
L
E
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
----------------
8
PsiBlast_PDB
72.78
26%
-88
- C3 -
1A4M
2
ADA_MOUSE
A:
[7-332]
--------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
F
G
K
K
R
G
I
A
L
P
A
D
T
V
E
E
L
----
R
N
I
I
---
G
---
M
D
K
P
L
S
-
L
P
G
F
L
A
K
----
F
D
Y
Y
M
-
P
V
I
A
G
-
C
R
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
LLANSKVDPMPW
N
------------
Q
T
E
------------
G
--
D
V
-------------
T
P
D
D
V
V
D
L
V
N
Q
G
L
Q
E
G
E
Q
A
F
G
I
K
V
R
S
I
L
C
C
M
R
H
QPSW
S
L
E
V
L
E
L
C
K
K
Y
N
Q
K
T
V
-------------
V
A
M
D
L
A
G
D
E
T
I
E
G
---
S
S
---
L
F
----
P
G
H
V
E
A
Y
E
G
A
V
K
N
G
I
H
R
T
V
H
A
G
E
V
G
S
P
-
E
V
V
R
E
A
V
D
I
L
K
T
E
R
V
G
H
G
Y
H
T
I
E
D
E
A
L
Y
N
R
L
L
K
E
N
M
H
F
E
V
C
P
W
S
S
Y
L
T
G
A
W
D
P
---
K
T
T
H
A
V
V
R
F
K
N
D
K
A
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
----------------
14
PsiBlast_PDB
72.53
26%
-89
- C3 -
1FKX
2
ADA_MOUSE
A:
[7-332]
--------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
F
G
K
K
R
G
I
A
L
P
A
D
T
V
E
E
L
----
R
N
I
I
---
G
---
M
D
KPL
S
-
L
P
G
F
L
A
K
----
F
D
Y
Y
M
-
P
V
I
A
G
-
C
R
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
LLANSKVDPMPW
N
------------
Q
T
E
------------
G
--
D
V
-------------
T
P
D
D
V
V
D
L
V
N
Q
G
L
Q
E
G
E
Q
A
F
G
I
K
V
R
S
I
L
C
C
M
R
H
QPSW
S
L
E
V
L
E
L
C
K
K
Y
N
Q
K
T
V
-------------
V
A
M
D
L
A
G
D
E
T
I
E
G
---
S
S
---
L
F
----
P
G
H
V
E
A
Y
E
G
A
V
K
N
G
I
H
R
T
V
H
A
G
E
V
G
S
P
-
E
V
V
R
E
A
V
D
I
L
K
T
E
R
V
G
H
G
Y
H
T
I
E
D
E
A
L
Y
N
R
L
L
K
E
N
M
H
F
E
V
C
P
W
S
S
Y
L
T
G
A
W
D
P
---
K
T
T
H
A
V
V
R
F
K
N
D
K
A
N
Y
S
L
N
T
D
A
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
----------------
20
PsiBlast_PDB
72.09
25%
-80
- C3 -
1NDV
2
ADA_BOVIN
A:
[9-328]
--------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
Y
G
K
R
R
G
I
A
L
P
A
D
T
P
E
E
L
----
Q
N
I
I
---
G
---
M
D
KPL
T
-
L
P
D
F
L
A
K
----
F
D
Y
Y
M
-
P
A
I
A
G
-
C
R
D
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
D
G
V
V
Y
V
E
V
R
Y
S
P
H
------------
L
------------
L
A
N
------------
S
--
K
V
EPIPWNQAEGDLT
P
D
E
V
V
-
S
L
V
N
Q
G
L
Q
E
G
E
R
D
F
G
V
K
V
R
S
I
L
C
C
M
R
H
-----------
Q
P
S
W
S
S
E
V
V
E
L
C
K
K
Y
R
-
E
Q
T
-
V
V
A
I
D
L
A
G
D
E
T
I
E
G
---
S
S
---
L
F
----
P
G
H
V
Q
A
Y
A
E
A
V
K
S
G
V
H
R
T
V
H
A
G
E
V
G
S
A
-
N
V
V
K
E
A
V
D
T
L
K
T
E
R
L
G
H
G
Y
H
T
L
E
D
T
T
L
Y
N
R
L
R
Q
E
N
M
H
F
E
I
C
P
W
S
S
Y
L
T
G
A
W
K
P
---
D
T
E
H
A
V
I
R
F
K
N
D
Q
V
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
----------------
19
PsiBlast_PDB
72.02
26%
-81
- C3 -
3IAR
5
ADA_HUMAN
A:
[7-326]
--------
P
K
V
E
L
H
V
H
L
D
G
S
I
K
P
E
T
I
L
Y
Y
G
R
R
R
G
I
A
L
P
A
N
T
A
E
G
L
----
L
N
V
I
---
G
---
M
D
K
P
L
T
-
L
P
D
F
L
A
K
----
F
D
Y
Y
M
-
P
A
I
A
G
-
C
R
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
------------
L
------------
L
A
N
------------
S
--
K
V
EPIPWNQAEGDLT
P
D
E
V
V
-
A
L
V
G
Q
G
L
Q
E
G
E
R
D
F
G
V
K
A
R
S
I
L
C
C
M
R
H
-----------
Q
P
N
W
S
P
K
V
V
E
L
C
K
K
Y
Q
-
Q
Q
T
-
V
V
A
I
D
L
A
G
D
E
T
-
I
P
---
G
S
---
S
L
L
P
G
H
V
---
Q
A
Y
Q
E
A
V
K
S
G
I
H
R
T
V
H
A
G
E
V
G
S
A
-
E
V
V
K
E
A
V
D
I
L
K
T
E
R
L
G
H
G
Y
H
T
L
E
D
Q
A
L
Y
N
R
L
R
Q
E
N
M
H
F
E
I
C
P
W
S
S
Y
L
T
G
A
W
K
P
---
D
T
E
H
A
V
I
R
L
K
N
D
Q
A
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
R
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
----------------
10
PsiBlast_PDB
71.89
26%
-87
- C3 -
3MVT
1
ADA_MOUSE
A:
[7-332]
--------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
F
G
K
K
R
G
I
A
L
P
A
D
T
V
E
E
L
----
R
N
I
I
---
G
---
M
D
K
P
L
S
-
L
P
G
F
L
A
K
----
F
D
Y
Y
M
-
P
V
I
A
G
-
C
R
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
LLANSKVDPMPW
N
------------
Q
T
E
------------
G
--
D
V
-------------
T
P
D
D
V
V
D
L
V
N
Q
G
L
Q
E
G
E
Q
A
F
G
I
K
V
R
S
I
L
C
C
M
R
H
QPSW
S
L
E
V
L
E
L
C
K
K
Y
N
Q
K
T
V
-------------
V
A
M
D
L
A
G
D
E
T
I
E
G
---
S
S
---
L
F
----
P
G
H
V
E
A
Y
E
G
A
V
K
N
G
I
H
R
T
V
H
A
G
E
V
G
S
P
-
E
V
V
R
E
A
V
D
I
L
K
T
E
R
V
G
H
G
Y
H
T
I
E
D
E
A
L
Y
N
R
L
L
K
E
N
M
H
F
E
V
C
P
W
S
S
Y
L
T
G
A
W
D
P
---
K
T
T
H
A
V
V
R
F
K
N
D
K
A
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
----------------
26
HHSearch
71.88
25%
-77
- C3 -
3IAR
5
ADA_HUMAN
A:
[2-333]
---
P
A
F
D
K
P
K
V
E
L
H
V
H
L
D
G
S
I
K
P
E
T
I
L
Y
Y
G
R
R
R
G
I
A
L
P
A
N
T
A
E
G
L
----
L
N
V
I
GMD
K
---
P
L
---
T
-
L
P
D
F
L
A
K
----
F
-
D
Y
Y
M
P
A
I
A
G
-
C
R
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
------------
L
------------
L
A
N
SKVEPIPWNQAE
G
--
D
L
-------------
T
P
D
E
V
V
A
L
V
G
Q
G
L
Q
E
G
E
R
D
F
G
V
K
A
R
S
I
L
C
C
M
R
H
----------
Q
P
N
-
W
S
P
K
V
V
E
L
C
K
K
Y
Q
Q
Q
-
T
-
V
V
A
I
D
L
A
G
D
E
T
I
P
G
SSL
L
P
---
G
H
----
V
---
Q
A
Y
Q
E
A
V
K
S
G
I
H
R
T
V
H
A
G
E
V
G
S
A
-
E
V
V
K
E
A
V
D
I
L
K
T
E
R
L
G
H
G
Y
H
T
L
E
D
Q
A
L
Y
N
R
L
R
Q
E
N
M
H
F
E
I
C
P
W
S
S
Y
L
T
G
A
W
K
P
---
D
T
E
H
A
V
I
R
L
K
N
D
Q
A
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
R
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
----------------
16
PsiBlast_PDB
71.66
26%
-85
- C3 -
1UIO
2
ADA_MOUSE
A:
[7-332]
--------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
F
G
K
K
R
G
I
A
L
P
A
D
T
V
E
E
L
----
R
N
I
I
---
G
---
M
D
K
P
L
S
-
L
P
G
F
L
A
K
----
F
D
Y
Y
M
-
P
V
I
A
G
-
C
R
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
LLANSKVDPMPW
N
------------
Q
T
E
------------
G
--
D
V
-------------
T
P
D
D
V
V
D
L
V
N
Q
G
L
Q
E
G
E
Q
A
F
G
I
K
V
R
S
I
L
C
C
M
R
H
QPSW
S
L
E
V
L
E
L
C
K
K
Y
N
Q
K
T
V
-------------
V
A
M
D
L
A
G
D
E
T
I
E
G
---
S
S
---
L
F
----
P
G
H
V
E
A
Y
E
G
A
V
K
N
G
I
H
R
T
V
H
A
G
E
V
G
S
P
-
E
V
V
R
E
A
V
D
I
L
K
T
E
R
V
G
A
G
Y
H
T
I
E
D
E
A
L
Y
N
R
L
L
K
E
N
M
H
F
E
V
C
P
W
S
S
Y
L
T
G
A
W
D
P
---
K
T
T
H
A
V
V
R
F
K
N
D
K
A
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
----------------
17
PsiBlast_PDB
71.38
30%
-78
- C3 -
4GXW
1
?
A:
[26-341]
----
F
H
A
L
P
K
V
E
L
H
C
H
L
L
G
A
V
R
H
D
T
F
V
A
L
A
Q
R
S
G
A
P
I
E
R
A
E
I
D
A
F
Y
ARG
E
K
P
V
---
G
---
V
L
---
H
-
V
L
R
A
L
D
R
----
Y
-------
L
L
T
-
R
P
D
D
L
R
R
I
A
Y
E
Y
L
E
D
A
A
A
H
N
V
R
H
A
E
F
F
W
N
P
-------------
T
------------
G
T
V
------------
R
VS
G
I
-------------
P
Y
A
D
A
Q
A
A
I
V
T
G
M
R
D
A
A
R
D
F
G
I
G
A
R
L
I
P
S
I
D
R
E
----------
Q
D
P
D
E
A
V
A
I
V
D
W
M
K
A
N
R
A
D
-
E
-
V
A
G
I
G
I
D
Y
R
E
N
D
R
P
---
P
E
---
L
F
----
W
---
K
A
Y
R
D
A
R
A
A
G
F
R
T
T
A
H
A
G
E
F
G
M
P
W
R
N
V
E
T
A
V
D
L
L
H
V
D
R
V
D
H
G
Y
T
I
V
D
N
P
E
L
C
A
R
Y
A
E
R
G
I
V
F
T
V
V
P
T
N
S
Y
Y
L
R
T
L
P
P
DQW
A
E
R
H
P
M
R
K
M
P
G
L
G
L
K
I
H
P
N
T
D
D
P
T
L
H
K
V
N
P
S
E
A
W
E
L
M
F
S
H
F
G
F
T
I
A
D
L
K
Q
F
M
L
N
G
I
D
G
A
W
V
D
----------------
7
PsiBlast_PDB
71.03
26%
-87
- C3 -
1A4L
2
ADA_MOUSE
A:
[7-332]
--------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
F
G
K
K
R
G
I
A
L
P
A
D
T
V
E
E
L
----
R
N
I
I
---
G
---
M
D
K
P
L
S
-
L
P
G
F
L
A
K
----
F
D
Y
Y
M
-
P
V
I
A
G
-
C
R
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
LLANSKVDPMPW
N
------------
Q
T
E
------------
G
--
D
V
-------------
T
P
D
D
V
V
D
L
V
N
Q
G
L
Q
E
G
E
Q
A
F
G
I
K
V
R
S
I
L
C
C
M
R
H
QPSW
S
L
E
V
L
E
L
C
K
K
Y
N
Q
K
T
V
-------------
V
A
M
D
L
A
G
D
E
T
I
E
G
---
S
S
---
L
F
----
P
G
H
V
E
A
Y
E
G
A
V
K
N
G
I
H
R
T
V
H
A
G
E
V
G
S
P
-
E
V
V
R
E
A
V
D
I
L
K
T
E
R
V
G
H
G
Y
H
T
I
E
D
E
A
L
Y
N
R
L
L
K
E
N
M
H
F
E
V
C
P
W
S
S
Y
L
T
G
A
W
D
P
---
K
T
T
H
A
V
V
R
F
K
N
D
K
A
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
----------------
6
PsiBlast_PDB
71.01
26%
-85
- C3 -
2ADA
2
ADA_MOUSE
A:
[10-335]
--------
P
K
V
E
L
H
V
H
L
D
G
A
I
K
P
E
T
I
L
Y
F
G
K
K
R
G
I
A
L
P
A
D
T
V
E
E
L
----
R
N
I
I
---
G
---
M
D
KPL
S
-
L
P
G
F
L
A
K
----
F
D
Y
Y
M
-
P
V
I
A
G
-
C
R
E
A
I
K
R
I
A
Y
E
F
V
E
M
K
A
K
E
G
V
V
Y
V
E
V
R
Y
S
P
H
LLANSKVDPMPW
N
------------
Q
T
E
------------
G
--
D
V
-------------
T
P
D
D
V
V
D
L
V
N
Q
G
L
Q
E
G
E
Q
A
F
G
I
K
V
R
S
I
L
C
C
M
R
H
QPSW
S
L
E
V
L
E
L
C
K
K
Y
N
Q
K
T
V
-------------
V
A
M
D
L
A
G
D
E
T
I
E
G
---
S
S
---
L
F
----
P
G
H
V
E
A
Y
E
G
A
V
K
N
G
I
H
R
T
V
H
A
G
E
V
G
S
P
-
E
V
V
R
E
A
V
D
I
L
K
T
E
R
V
G
H
G
Y
H
T
I
E
D
E
A
L
Y
N
R
L
L
K
E
N
M
H
F
E
V
C
P
W
S
S
Y
L
T
G
A
W
D
P
---
K
T
T
H
A
V
V
R
F
K
N
D
K
A
N
Y
S
L
N
T
D
D
P
L
I
F
K
S
T
L
D
T
D
Y
Q
M
T
K
K
D
M
G
F
T
E
E
E
F
K
R
L
N
I
N
A
A
K
S
S
F
L
P
----------------