@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0158: (2015-12-24 )
MKGGFNLSDWALRHQSLVWYLMAVSLVMGVFSYLNLGREEDPSFAIKTMVIQTRWPGATVDDTLEQVTDRIEKKLEELDSLDYVKSYTRPGESTVFVYLKDTTKAGDIPDIWYQVRKKISDIQGEFPQGIQGPGFNDEFGDVFGSVYAFTADGLDFRQLRDYVEKVRLDIRSVKDLGKVQMIGAQNEVIYLNFSTRKLAALGLDQRQVVQSLQAQNAVTPSGVVEAGPERISVRTSGNFRSEKDLQAVNLRVNDRFYRLSDLASISRDFVDPPTSLFRYKGEPAIGLAVAMKEGGNILEFGEALNARMQEITGELPVGVGVHQVSNQAQVVKKAVGGFTRALFEAVVIVLIVSFVSLGLRAGLVVACSIPLVLAMVFVFMEYTDITMQRVSLGALIIALGLLVDDAMITVEMMITRLELGDSLHDSATYAYTSTAFPMLTGTLVTVAGFVPIGLNASSAGEYTFTLFAVIAVALLLSWIVAVLFAPVIAVHILPKTLKHKSEQKKGRIAERFDSLLHLAMRRRWTTIFLTALLFGVSLFLMKFVQHQFFPSSDRPELLVDLNLPQNSSIHETRAVMDRLEATLKDDEDIDHWSAYVGEGAIRFYLPLDQQLQNNFYGQLVIVTKDLEARERVAARLRDRLRKDYVGISTYVQPLEMGPPVGRPIQYRVSGPQIDKVREYAMGLAGVLDGNPNIGDIVYDWNEPGKMLKIDIAQDKARQLGLSSEDVAQIMNSVVTGSAVTQVRDDIYLVNVIGRAEDSERGSLETLESLQIVTPSGTSIPLKAFAKVSYELEQPLVWRRDRKPTITVKASLRGEIQPTDLVARLAPEVKRFADGLPANYRIEVGGTVEESGKAEGPIAKVVPLMLFLMATFLMIQLQSVQKLFLVASVAPLGLIGVVAALLPTGTPMGFVAILGILALIGIIIRNSVILVTQIDAFEKDGKTPWEAVLEATHHRTRPILLTAAAASLGMIPIAREVFWGPMAYAMIGGIVAATLLTLIFLPALYVAWYRIPEPGR
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........70........80....-...-.-90.....-....100.......110.....--...120.......130....-----.-.-----.140........150-----..--.--......160-.-..-....-170.......180......-.190.......200.......210.......220...----...----.------230----.....--....240.....-....250-..---.--...--.--.260.......270..--.....280...-....290.......300.......310..-.....320.......330.......340.......350.....-..-360.......370.......380.......390.......400.......410.....--.-.-420.--......---------430.......440......-----.450----.......460.-.....-.470.......480.......490.-......500..--------.....---510....-----------..---------..520.......530........540.......550.......560.......570....---...580....--...590.....---..600....-...610.......620...----------....-------630-------.........640--.---....-----...650...--..-----..-----..660---....----..-.-..---670------------.......680.-------.....--.690-.......700.......710.......720.......730.......740....--...750.......760.......770.......780.......790.......800..--.....810......-.820.......830....---...840-.......--850........860.......870...--....880.......890.......900----........-----------.910-----------.......920----.......930....-....940.......950.----......960.......970-------------.-----.-----.--.---....-----980-------...-----......990.......1000......1010..
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MKGGF
N
L
S
D
W
A
L
R
H
Q
S
L
V
W
Y
L
M
A
V
S
L
V
M
G
V
F
S
Y
L
NLGREEDPS
F
A
I
K
T
M
V
I
Q
TRWPGA
T
V
D
D
T
L
E
Q
V
T
D
R
I
E
K
K
L
E
E
LD
S
L
D
Y
V
K
-
S
YT-R-P-GE
S
T
V
-
F
V
Y
LKDTTKAGDI
P
D
I
-
W
Y
Q
V
R
--
K
K
I
S
D
IQGEFPQGIQGPGFN-----
D
-
E
-----
F
G
-
D
V
F
G
S
V
Y
A
FT-------AD--G--L
D
F
R
Q
L
R
D
Y
-
V
-
E
K
-
V
R
L
D
-
I
R
S
V
K
DLG
K
V
Q
M
IGAQN
E
V
-
I
Y
L
NFSTR
K
L
A
ALGL
D
Q
R
Q
V
V
Q
S
L
Q
AQNAVTPSGVVE----AGP----
E
------
R
------
I
S
V
RT--SGNFR--SEKD
L
-
Q
A
V
N
L
R
--VN---D--R
F
Y
--
R
--
L
S
D
L
A
S
I
S
R
DFVDPP
T
--
S
L
FRYKGEPA
I
-
G
L
A
V
A
MKEGGN
I
L
E
F
G
E
A
L
N
A
R
M
Q
E
I
TGE-LPVG
V
G
V
H
Q
VS
N
Q
A
Q
V
V
K
K
A
V
G
G
F
T
R
A
L
F
E
A
V
V
I
V
L
I
V
S
F
V
S
L
-
G
L
-RA
G
L
V
V
A
C
S
I
P
L
V
L
A
M
V
F
V
F
M
E
YT
D
I
T
M
Q
R
V
S
L
G
A
L
I
I
A
L
G
L
L
VD
D
A
M
I
T
V
E
M
M
I
T
R
L
--E-L-GDSL--HDS
A
T
Y
---------
A
Y
TSTAFPM
L
T
G
T
L
V
T
V
A
G
-----
F
V
P
I----GLNASSAG
E
Y
T
-
F
T
L
F
A
-
V
I
A
V
A
L
L
L
S
W
I
V
A
V
L
F
A
P
V
I
A
V
H
I
L
-
P
K
T
L
K
H
K
S
E
Q
K
--------
K
G
R
I
A
---
E
R
-
F
D
S
L
-----------
L
H
---------
L
A
M
R
R
R
W
T
T
I
F
L
T
-
A
L
L
F
G
V
S
L
F
L
M
K
F
V
Q
H
QFFPSSDRP
E
L
L
V
D
L
NLPQNSS
I
H
E
T
R
A
V
M
---
D
R
L
E
A
T
LKDD--ED
I
D
H
W
S
A
Y
VG---E
G
A
I
R
F
Y
LP-
L
D
Q
Q
L
Q
NNFY
G
Q
L
V
I
V
TK
D
----------
L
E
A
R
-------
E
---------
R
V
A
A
R
L
R
D
R
L
R
---
K
---
D
YVG-----
I
S
T
Y
--
V
Q
P--LE-----MG-----PPV-----GR
P
I
----
Q
Y
-R-VS---GP
Q
------------
I
D
K
V
R
E
Y
A
M
G
L
-------
A
G
VLD--GNPN-IG
D
I
V
Y
DWNEPG
K
M
L
K
I
DIAQ
D
K
A
R
QLGL
S
S
E
D
V
A
Q
I
M
N
S
VVTG
S
A
V
T
Q
VRD
D
I
--
Y
L
V
N
V
IGRAEDSERG
S
L
E
T
L
E
S
L
Q
I
VTPSGTS
I
P
L
K
A
F
A
K
V
S
YELEQP
L
V
WRRDRK
P
T
--
I
T
V
K
A
SLRGEI
Q
P
T
-
D
L
V
A
R
L
A
P
E
V
K
R
F
ADGLP---A
N
Y
R
I
E
-VGGTVEE--S-GKAEG
P
I
A
K
V
V
P
L
M
L
F
L
M
A
T
F
L
M
I
Q
--
L
Q
S
V
Q
K
L
F
L
V
ASVA
P
L
G
L
I
G
V
V
A
A
L------LPTGTP
M
G
-----------
F
V
A
I
-----------
L
G
I
L
A
L
I
G
I
I
----IRN
S
V
I
L
V
T
-QIDA-FEKDGK
T
P
W
E
A
V
L
E
A
THH----RTR
P
I
L
L
T
A
A
A
ASLGM
I
P
--------------
I
-----
A
-----
R
--
E
---
V
F
W
G
-----
P
---------
M
A
Y
-----
A
M
I
G
G
I
V
A
A
T
L
L
T
L
I
F
L
P
A
L
Y
V
A
W
YRIPEPGR
1
PsiBlast_PDB
86.70
25%
-104
- C2 -
4K0J
1
?
A:
[9-1012]
----------
C
F
N
R
R
G
I
V
A
L
V
F
A
M
V
A
L
Y
G
W
Y
A
W
K
Q
L
P
L
E
A
Y
P
D
I
A
D
T
T
S
Q
V
V
T
Q
V
N
G
L
A
A
E
E
V
E
Q
Q
I
T
I
P
L
E
R
E
I
M
G
V
P
G
M
H
V
M
R
-
S
K
S
-
T
-
F
-
G
L
S
L
I
-
T
V
V
F
K
D
G
A
E
-----
D
Y
-
W
S
R
Q
R
L
Q
E
R
I
N
G
V
--
S
L
P
Y
G
A
Q
-
P
S
L
------
D
-
P
-----
L
T
-
S
P
I
G
E
I
Y
R
Y
T
L
V
-----
S
K
--
T
--
R
D
L
R
E
L
S
E
L
Q
F
-
W
K
-
V
I
P
R
-
L
K
Q
V
A
G
V
V
D
V
A
N
F
G
G
L
T
T
Q
-
F
M
L
E
F
D
P
V
M
L
S
K
Y
N
I
S
L
N
Q
I
T
Q
A
I
S
E
N
N
A
N
A
G
G
S
I
L
N
----
R
G
E
----
Q
------
G
------
L
V
V
R
G
--
V
G
L
I
R
--
N
L
D
D
L
G
N
I
V
V
T
Q
----------------------
G
R
V
V
L
G
N
P
Q
R
H
G
--
I
L
G
M
D
R
N
P
D
T
I
-
Q
G
I
T
L
L
L
K
N
E
N
P
S
V
V
M
E
G
V
H
A
A
V
R
D
L
N
D
N
I
L
P
K
D
V
K
V
V
P
Y
I
D
R
S
N
L
V
D
A
T
V
H
T
V
G
K
T
L
M
E
G
M
F
L
V
S
L
V
L
L
L
F
L
-
G
S
P
R
A
A
I
I
V
A
V
T
I
P
L
S
L
L
M
A
F
I
L
M
H
H
F
K
I
P
A
N
L
L
S
L
G
A
--
I
D
F
G
I
I
V
D
G
A
I
V
V
M
E
N
I
L
R
R
R
--------------
D
I
M
Q
---------
S
V
L
Q
V
A
R
P
I
F
F
G
M
I
V
I
I
T
A
-----
Y
L
P
------
L
F
A
F
Q
R
I
E
Y
K
L
F
S
P
M
A
F
A
V
G
F
A
L
F
G
A
L
L
V
A
L
L
L
I
P
G
L
A
---------------
A
--------
L
V
W
L
A
---
P
R
-
Y
E
S
V
-----------
L
N
---------
R
---
S
T
R
T
A
I
G
I
A
V
A
T
L
V
G
V
-
M
I
L
G
A
T
I
G
R
D
F
L
P
Y
L
D
E
G
S
I
W
L
Q
V
T
L
P
P
G
I
S
L
E
K
A
G
Q
M
A
---
D
N
L
R
A
A
T
M
E
F
--
P
E
V
E
H
V
V
T
Q
V
G
RND
E
G
T
D
P
F
S
P
S
H
I
E
T
A
V
T
L
H
P
Y
S
T
W
T
S
G
R
D
K
----------
Q
Q
L
I
-------
E
---------
A
M
A
T
R
F
R
D
-
L
P
---
G
---
T
Q
V
G
-----
F
S
-----
Q
P
--
M
I
-----
D
G
V
L
D
K
L
A
G
A
-----
H
S
D
L
----
V
V
-
K
-
V
Y
---
G
N
D
------------
F
A
E
T
R
Q
V
A
T
A
I
-------
T
R
L
L
K
--
T
V
P
G
-
A
Q
D
V
I
I
D
Q
E
P
P
L
P
Q
V
R
I
D
V
D
R
A
A
A
A
R
L
G
I
N
V
A
D
V
M
A
L
I
Q
T
G
I
G
G
S
P
V
T
Q
V
F
V
E
D
--
R
S
Y
N
V
V
A
R
F
I
G
S
S
R
N
D
P
E
A
I
G
N
L
T
L
T
A
A
N
G
A
H
V
A
L
A
Q
V
A
H
I
R
L
A
E
G
E
T
T
I
T
R
E
M
N
K
R
H
--
L
T
V
R
L
N
L
R
G
R
-----
D
L
S
T
F
L
E
E
A
R
M
R
I
D
K
E
V
P
YDR
T
H
I
Q
V
A
-
W
G
G
Q
F
E
N
--
Q
-
Q
R
A
Q
A
R
L
A
V
I
L
P
M
V
L
A
L
M
F
V
L
L
F
---------
Q
P
A
L
I
L
M
A
V
P
L
A
T
L
G
G
L
V
A
L
------
H
L
R
G
M
T
L
N
-----------
V
S
S
A
-----------
V
G
F
I
A
L
F
G
V
A
----
V
L
N
A
I
I
M
I
A
-
N
L
-----------
K
E
A
V
V
R
G
A
G
E
----
R
M
R
P
V
L
M
T
A
T
V
A
A
L
G
L
I
P
--------------
A
-----
A
-----
L
--
A
---
H
G
L
G
S
D
V
Q
R
P
---------
L
A
T
-----
V
V
V
G
G
L
I
T
A
T
A
L
T
L
V
L
L
P
A
L
Y
Y
L
I
E
T
R
-----
16
PsiBlast_PDB
83.38
23%
-98
- C2 -
4DX7
10
ACRB_ECOLI
A:
[11-1019]
----------------
F
A
W
V
I
A
I
I
I
M
L
A
G
G
L
A
I
L
K
L
P
V
A
Q
Y
P
T
I
A
P
P
A
V
T
I
S
A
S
Y
P
G
A
D
A
K
T
V
Q
D
T
V
T
Q
V
I
E
Q
N
M
N
G
I
D
N
L
M
Y
M
S
-
S
N
S
------
D
S
T
G
-
T
V
Q
I
T
L
T
F
E
S
G
T
D
A
D
I
A
Q
V
Q
V
Q
--
N
K
L
Q
L
A
M
P
L
L
P
Q
E
V
Q
Q
Q
G
V
S
-----
V
-
E
K
S
S
SS
F
L
-
M
V
V
G
V
I
---
N
-------
T
D
--
G
T-
M
T
Q
E
D
I
S
D
Y
-
V
-
A
A
-
N
M
K
D
A
I
S
R
T
S
G
V
G
D
V
Q
L
F
G
S
Q
Y
A
M
R
I
W
M
N
--
P
N
E
L
N
K
F
Q
L
T
P
V
D
V
I
T
A
I
K
A
Q
N
A
Q
V
A
A
G
Q
L
G
----
G
T
P
----
P
VKGQQ
L
N
------
A
S
I
I
A
--
Q
T
R
L
T
--
S
T
E
E
F
-
G
K
I
L
L
K
--
V
N
---
Q
--
D
G
S
--
R
V
L
L
R
D
V
A
K
I
E
L
G
G
E
N
Y
D
I
---
I
A
E
F
N
G
Q
P
A
S
-
G
L
G
I
K
L
A
T
G
A
N
A
L
D
T
A
A
A
I
R
A
E
L
A
K
M
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P
F
-
F
P
S
G
L
K
I
V
Y
P
Y
D
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T
P
F
V
K
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I
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V
V
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T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
-
R
A
T
L
I
P
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
-
N
V
E
R
V
--
M
-
A
-
E
E
G
L
--
P
P
K
E
A
------------
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
----
A
F
F
G
G
S
T
G
A
I
Y
-
R
Q
F
S
I
-
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
P
I
A
K
G
D
H
G
E
G
K
--------
K
G
F
F
G
W
F
N
R
M
-
F
E
K
S
-----------
T
H
H
Y
T
D
S
V
G
G
I
L
R
S
T
G
R
Y
L
V
L
Y
L
I
-
I
V
V
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M
A
Y
L
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--
L
P
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V
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M
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M
V
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L
P
A
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A
T
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E
R
T
Q
K
V
L
---
N
E
V
T
H
Y
Y
L
T
K
--
E
K
N
N
V
E
S
V
F
A
V
---
N
G
-----
F
G
-
F
A
G
R
G
Q
N
T
--
G
I
A
F
V
S
L
K
D
WADRPGEENK
V
E
A
I
-------
T
---------
M
R
A
T
R
A
F
S
Q
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K
---
D
---
A
M
V
F
-----
A
F
N
L
--
P
A
I
--
V
E
-----
L
G
-----
T
A
T
-----
G
F
D
F
----
E
L
I
D
-
Q
A
---
G
L
G
------------
H
E
K
L
T
Q
A
R
N
Q
L
-------
L
A
E
A
A
--
K
H
P
D
M
L
T
S
V
R
P
N
G
L
E
D
T
P
Q
F
K
I
D
I
D
Q
E
K
A
Q
A
L
G
V
S
I
N
D
I
N
T
T
L
G
A
A
W
G
G
S
Y
V
N
D
F
I
D
R
G
--
R
V
K
K
V
Y
V
M
S
E
A
K
Y
R
M
L
P
D
D
I
G
D
W
Y
V
R
A
A
D
G
Q
M
V
P
F
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A
F
S
S
S
R
W
E
Y
G
S
P
R
L
E
R
Y
N
G
L
P
S
--
M
E
I
----
L
G
Q
A
A
P
G
-
K
S
T
G
E
A
M
E
L
M
E
Q
L
A
S
K
L
P
---
T
G
V
G
Y
D
W
T
G
M
S
Y
Q
E
RL
S
-
G
N
Q
A
P
S
L
Y
A
I
S
L
I
V
V
F
L
C
L
A
A
L
-----
Y
E
S
W
S
I
P
F
S
V
M
L
V
V
P
L
G
V
I
G
A
L
L
A
A
------
T
F
R
G
L
T
N
D
-----------
V
Y
F
Q
-----------
V
G
L
L
T
T
I
G
L
S
----
A
K
N
A
I
L
I
V
E
F
A
K
D
L
-
M
D
K
E
G
K
G
L
I
E
A
T
L
D
A
V
R
M
----
R
L
R
P
I
L
M
T
S
L
A
F
I
L
G
V
M
P
--------------
L
-----
V
-----
I
--
S
---
T
G
A
G
-----
S
---------
G
A
Q
N
A
V
G
T
G
V
M
G
G
M
V
T
A
T
V
L
A
I
F
F
V
P
V
F
F
V
V
V
R
R
R
F
S
R
K
N
8
PsiBlast_PDB
83.17
22%
-104
- C2 -
3K0I
2
CUSA_ECOLI
A:
[33-1043]
--------------------------
I
W
G
T
W
T
I
I
N
T
P
V
D
A
L
P
D
L
S
D
V
Q
V
I
I
K
T
S
Y
P
G
Q
A
P
Q
I
V
E
N
Q
V
T
Y
P
L
T
T
T
M
L
S
V
P
G
A
K
T
V
R
-
G
F
S
-
Q
-
F
-
G
D
S
Y
V
-
Y
V
I
F
E
D
G
T
D
P
-----
Y
-
W
A
R
S
R
V
L
E
Y
L
N
Q
V
Q
G
K
L
P
A
G
V
S
A
E
L
G
P
-----
D
-
A
-----
T
G
---
V
G
W
I
Y
E
Y
A
L
V
D
RSGK
H
D
--
L
--
A
D
L
R
S
L
Q
D
W
-
F
----
L
K
Y
E
-
L
K
T
I
P
D
V
A
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V
A
S
V
G
G
V
V
K
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-
Y
Q
V
V
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D
P
Q
R
L
A
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Y
G
I
S
L
A
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V
K
S
A
L
D
A
S
N
Q
E
A
G
G
S
S
I
E
----
L
A
E
----
A
------
E
------
Y
M
V
R
A
--
S
G
Y
L
Q
--
T
L
D
D
F
-
N
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I
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L
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--
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---
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--
N
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A
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---
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A
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L
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G
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A
I
A
V
G
A
M
V
D
A
A
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V
M
I
E
N
A
H
K
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L
--
E
-
E
-
W
Q
H
Q
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T
R
W
Q
V
I
T
D
A
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V
E
V
G
P
A
L
F
I
S
L
L
I
I
T
L
S
-----
F
I
P
I
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G
Q
E
G
R
L
F
G
P
L
A
-
F
T
K
T
Y
-
A
M
A
G
A
A
L
L
----
A
I
V
V
I
P
I
L
M
G
Y
-------------
P
--------
L
N
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F
L
---
I
R
V
Y
H
P
L
-----------
L
L
---------
K
V
L
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W
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K
T
T
L
L
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A
-
A
L
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V
L
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L
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P
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G
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L
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P
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A
A
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---
Q
K
T
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K
L
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--
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A
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V
F
G
K
T
G
---
K
A
----------
E
T
A
T
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S
A
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L
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M
V
E
T
T
I
Q
----------
L
K
P
Q
-------
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QWRPGMT
M
D
K
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I
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E
L
D
N
T
V
R
---
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---
P
G
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A
------
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--
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--
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-----
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-----
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----
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-
K
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V
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---
G
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------------
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A
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-------
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A
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A
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A
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L
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M
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A
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V
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T
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M
L
K
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A
R
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T
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W
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A
R
D
R
D
M
V
S
V
V
H
D
L
Q
K
A
I
A
E
K
V
Q
-----
L
K
---
P
G
T
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V
A
-
F
S
G
Q
F
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L
--
L
-
E
R
A
N
H
K
L
K
L
M
V
P
M
T
L
M
I
I
F
V
L
L
Y
L
A
--
F
R
R
V
G
E
A
L
L
I
I
S
S
V
P
F
A
L
V
G
G
I
W
L
L
W
W
M
G
F
H
L
S
V
A
T
G
T
G
-----------
F
I
A
L
-----------
A
G
V
A
A
E
F
G
V
V
M
L
M
Y
L
R
H
A
I
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A
V
P
-
S
L
N
N
-
P
Q
T
F
S
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---
Q
K
L
D
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A
L
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H
G
A
V
L
R
V
R
P
K
A
M
T
V
A
V
I
I
A
G
L
L
P
--------------
I
-------------------
L
W
G
-----
T
GAGS
E
V
M
S
R
I
A
A
-----
P
M
I
G
G
M
I
T
A
P
L
L
S
L
F
I
I
P
A
A
Y
K
L
M
W
-------
15
PsiBlast_PDB
83.12
23%
-97
- C2 -
4DX5
14
ACRB_ECOLI
A:
[11-1019]
----------------
F
A
W
V
I
A
I
I
I
M
L
A
G
G
L
A
I
L
K
L
P
V
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P
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A
P
P
A
V
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A
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Y
P
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A
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A
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D
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Q
V
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Q
N
M
N
G
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D
N
L
M
Y
M
S
-
S
N
S
------
D
S
T
G
-
T
V
Q
I
T
L
T
F
E
S
G
T
D
A
D
I
A
Q
V
Q
V
Q
--
N
K
L
Q
L
A
M
P
L
L
P
Q
E
V
Q
Q
Q
G
V
S
-----
V
-
E
K
S
S
SS
F
L
-
M
V
V
G
V
I
---
N
-------
T
D
--
G
T-
M
T
Q
E
D
I
S
D
Y
-
V
-
A
A
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N
M
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D
A
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R
T
S
G
V
G
D
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Q
L
F
G
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Y
A
M
R
I
W
M
N
--
P
N
E
L
N
K
F
Q
L
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V
D
V
I
T
A
I
K
A
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N
A
Q
V
A
A
G
Q
L
G
----
G
T
P
----
P
VKGQQ
L
N
------
A
S
I
I
A
--
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T
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L
T
--
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T
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E
F
-
G
K
I
L
L
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--
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N
---
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--
D
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S
--
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V
L
L
R
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A
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G
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---
I
A
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F
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-
G
L
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-
N
V
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--
M
-
A
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E
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L
--
P
P
K
E
A
------------
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
----
A
F
F
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G
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T
G
A
I
Y
-
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Q
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S
I
-
T
I
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T
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A
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C
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I
A
K
G
D
H
G
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G
K
--------
K
G
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F
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W
F
N
R
M
-
F
E
K
S
-----------
T
H
H
Y
T
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G
G
I
L
R
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R
Y
L
V
L
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A
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T
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K
V
L
---
N
E
V
T
H
Y
Y
L
T
K
--
E
K
N
N
V
E
S
V
F
A
V
---
N
G
-----
F
G
-
F
A
G
R
G
Q
N
T
--
G
I
A
F
V
S
L
K
D
WADRPGEENK
V
E
A
I
-------
T
---------
M
R
A
T
R
A
F
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Q
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K
---
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---
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M
V
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-----
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L
--
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--
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-----
L
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-----
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A
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-----
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----
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L
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Q
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---
G
L
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------------
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-------
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G
Q
M
V
P
F
S
A
F
S
S
S
R
W
E
Y
G
S
P
R
L
E
R
Y
N
G
L
P
S
--
M
E
I
----
L
G
Q
A
A
P
G
-
K
S
T
G
E
A
M
E
L
M
E
Q
L
A
S
K
L
P
---
T
G
V
G
Y
D
W
T
G
M
S
Y
Q
E
RL
S
-
G
N
Q
A
P
S
L
Y
A
I
S
L
I
V
V
F
L
C
L
A
A
L
-----
Y
E
S
W
S
I
P
F
S
V
M
L
V
V
P
L
G
V
I
G
A
L
L
A
A
------
T
F
R
G
L
T
N
D
-----------
V
Y
F
Q
-----------
V
G
L
L
T
T
I
G
L
S
----
A
K
N
A
I
L
I
V
E
F
A
K
D
L
-
M
D
K
E
G
K
G
L
I
E
A
T
L
D
A
V
R
M
----
R
L
R
P
I
L
M
T
S
L
A
F
I
L
G
V
M
P
--------------
L
-----
V
-----
I
--
S
---
T
G
A
G
-----
S
---------
G
A
Q
N
A
V
G
T
G
V
M
G
G
M
V
T
A
T
V
L
A
I
F
F
V
P
V
F
F
V
V
V
R
R
R
F
S
R
K
N
3
PsiBlast_PDB
83.05
23%
-101
- C2 -
3W9J
5
MEXB_PSEAE
A:
[1-1026]
------
M
S
K
F
F
I
D
R
P
I
F
A
W
V
I
A
L
V
I
M
L
A
G
G
L
S
I
L
S
L
P
V
N
Q
Y
P
A
I
A
P
P
A
I
A
V
Q
V
S
Y
P
G
A
S
A
E
T
V
Q
D
T
V
V
Q
V
I
E
Q
Q
M
N
G
I
D
N
L
R
Y
I
S
-
S
E
S
-
N
-
S
D
G
S
M
T
I
-
T
V
----
T
F
E
Q
G
T
D
P
D
I
A
Q
V
Q
V
Q
--
N
K
L
Q
L
A
T
P
L
L
P
Q
E
V
Q
R
Q
G
I
R
V
T
KAV
K
-
N
-----
F
L
-
M
V
V
G
V
V
---
S
-------
T
D
--
G
S-
M
T
K
E
D
L
S
N
Y
I
V
-
S
N
-
I
Q
D
P
-
L
S
R
T
K
G
V
G
D
F
Q
V
F
G
S
Q
Y
S
M
R
I
W
L
D
--
P
A
K
L
N
S
Y
Q
L
T
P
G
D
V
S
S
A
I
Q
A
Q
N
V
Q
I
S
S
G
Q
L
G
----
G
L
P
AVKG
Q
------
Q
------
L
N
A
T
I
--
I
G
K
T
R
L
Q
T
A
E
Q
F
-
E
N
I
L
L
K
--
V
N
PD-
G
--
S
Q
V
--
R
--
L
K
D
V
A
D
V
G
L
G
G
Q
D
Y
S
I
--
N
A
-
Q
F
N
G
S
P
A
S
-
G
I
A
I
K
L
A
T
G
A
N
A
L
D
T
A
K
A
I
R
Q
T
I
A
N
L
E
P
F
-
M
P
Q
G
M
K
V
V
Y
P
Y
D
T
T
P
V
V
S
A
S
I
H
E
V
V
K
T
L
G
E
A
I
L
L
V
F
L
V
M
Y
L
F
L
Q
N
F
-
R
A
T
L
I
P
T
I
A
V
P
V
V
L
L
G
T
F
G
V
L
A
A
F
G
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
-
N
V
E
R
V
M
A
E
-
E
-
G
L
S
P
--
R
E
A
A
R
K
---------
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
-----
F
L
P
M
----
A
F
F
G
G
S
T
G
V
I
Y
-
R
Q
F
S
I
-
T
I
V
S
A
M
A
L
S
V
I
V
A
L
I
L
T
P
A
L
C
A
T
M
L
-
K
P
--------------------
F
F
---
G
W
-
F
N
R
M
F
L
S
T
T
H
G
Y
E
R
G
V
A
---------
S
I
L
K
H
R
A
P
Y
L
L
I
Y
-
V
V
I
V
A
G
M
I
W
M
F
T
R
I
P
T
A
F
L
P
D
E
D
Q
G
V
L
F
A
Q
V
Q
T
P
P
G
S
S
A
E
R
T
Q
V
V
V
---
D
S
M
R
E
Y
L
L
E
K
--
E
S
S
S
V
S
S
V
F
T
V
---
T
G
--------
F
N
F
A
G
R
G
Q
S
S
G
M
A
F
I
M
L
K
P
----------
W
E
E
R
PGG----
E
---------
N
S
V
F
E
L
A
K
R
A
Q
---
M
---
H
F
F
S
FKDAM
V
F
A
F
--
A
P
P
SV
L
E
-----
L
G
-----
N
A
T
-----
G
F
D
L
F
LQD
Q
A
-
G
-
V
G
---
H
E
V
------------
L
L
Q
A
R
N
K
F
L
M
L
-------
A
A
-----
Q
N
P
A
-
L
Q
R
V
R
P
N
G
M
S
D
E
P
Q
Y
K
L
E
I
D
D
E
K
A
S
A
L
G
V
S
L
A
D
I
N
S
T
V
S
I
A
W
G
S
S
Y
V
N
D
F
I
D
R
G
--
R
V
K
R
V
Y
L
Q
G
R
P
D
A
R
M
N
P
D
D
L
S
K
W
Y
V
R
N
D
K
G
E
M
V
P
F
N
A
F
A
T
G
K
W
E
Y
G
S
P
K
L
E
R
Y
N
G
V
P
A
--
M
E
I
L
G
E
P
A
P
G
L
S
S
G
-
D
A
M
A
A
V
E
E
I
V
K
Q
L
P
K
G
V
G
---
Y
S
W
----
T
G
L
S
Y
E
E
--
R
L
S
G
S
Q
A
P
A
L
Y
A
L
S
L
L
V
V
F
L
C
L
A
A
L
Y
E
--
S
W
S
I
P
--
F
S
V
M
L
V
V
P
L
G
V
I
G
A
L
L
A
T
------
S
M
R
G
L
S
N
D
-----------
V
F
F
Q
-----------
V
G
L
L
T
T
I
G
L
S
----
A
K
N
A
I
L
I
V
E
-
F
A
K
E
-
L
H
E
Q
G
K
G
I
V
E
A
A
I
E
A
C
R
M
----
R
L
R
P
I
V
M
T
S
L
A
F
I
L
G
V
V
P
--------------
L
-----
A
-----
I
--
S
---
T
G
A
G
-----
S
G
S
Q
H
A
----
I
G
T
-----
G
V
I
G
G
M
V
T
A
T
V
L
A
I
F
W
V
P
L
F
Y
V
A
V
S
T
L
-----
4
PsiBlast_PDB
83.01
23%
-100
- C2 -
3W9I
5
MEXB_PSEAE
A:
[1-1026]
------
M
S
K
F
F
I
D
R
P
I
F
A
W
V
I
A
L
V
I
M
L
A
G
G
L
S
I
L
S
L
P
V
N
Q
Y
P
A
I
A
P
P
A
I
A
V
Q
V
S
Y
P
G
A
S
A
E
T
V
Q
D
T
V
V
Q
V
I
E
Q
Q
M
N
G
I
D
N
L
R
Y
I
S
-
S
E
S
-
N
-
S
D
G
S
M
T
I
-
T
V
----
T
F
E
Q
G
T
D
P
D
I
A
Q
V
Q
V
Q
--
N
K
L
Q
L
A
T
P
L
L
P
Q
E
V
Q
R
Q
G
I
R
V
T
KAV
K
-
N
-----
F
L
-
M
V
V
G
V
V
---
S
-------
T
D
--
G
S-
M
T
K
E
D
L
S
N
Y
I
V
-
S
N
-
I
Q
D
P
-
L
S
R
T
K
G
V
G
D
F
Q
V
F
G
S
Q
Y
S
M
R
I
W
L
D
--
P
A
K
L
N
S
Y
Q
L
T
P
G
D
V
S
S
A
I
Q
A
Q
N
V
Q
I
S
S
G
Q
L
G
----
G
L
P
AVKG
Q
------
Q
------
L
N
A
T
I
--
I
G
K
T
R
L
Q
T
A
E
Q
F
-
E
N
I
L
L
K
--
V
N
PD-
G
--
S
Q
V
--
R
--
L
K
D
V
A
D
V
G
L
G
G
Q
D
Y
S
I
--
N
A
-
Q
F
N
G
S
P
A
S
-
G
I
A
I
K
L
A
T
G
A
N
A
L
D
T
A
K
A
I
R
Q
T
I
A
N
L
E
P
F
-
M
P
Q
G
M
K
V
V
Y
P
Y
D
T
T
P
V
V
S
A
S
I
H
E
V
V
K
T
L
G
E
A
I
L
L
V
F
L
V
M
Y
L
F
L
Q
N
F
-
R
A
T
L
I
P
T
I
A
V
P
V
V
L
L
G
T
F
G
V
L
A
A
F
G
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
-
N
V
E
R
V
M
A
E
-
E
-
G
L
S
P
--
R
E
A
A
R
K
---------
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
-----
F
L
P
M
----
A
F
F
G
G
S
T
G
V
I
Y
-
R
Q
F
S
I
-
T
I
V
S
A
M
A
L
S
V
I
V
A
L
I
L
T
P
A
L
C
A
T
M
L
-
K
P
--------------------
F
F
---
G
W
-
F
N
R
M
F
L
S
T
T
H
G
Y
E
R
G
V
A
---------
S
I
L
K
H
R
A
P
Y
L
L
I
Y
-
V
V
I
V
A
G
M
I
W
M
F
T
R
I
P
T
A
F
L
P
D
E
D
Q
G
V
L
F
A
Q
V
Q
T
P
P
G
S
S
A
E
R
T
Q
V
V
V
---
D
S
M
R
E
Y
L
L
E
K
--
E
S
S
S
V
S
S
V
F
T
V
---
T
G
--------
F
N
F
A
G
R
G
Q
S
S
G
M
A
F
I
M
L
K
P
----------
W
E
E
R
PGG----
E
---------
N
S
V
F
E
L
A
K
R
A
Q
---
M
---
H
F
F
S
FKDAM
V
F
A
F
--
A
P
P
SV
L
E
-----
L
G
-----
N
A
T
-----
G
F
D
L
F
L
Q
D
Q
A
-
G
-
V
G
---
H
E
V
------------
L
L
Q
A
R
N
K
F
L
M
L
-------
A
A
-----
Q
N
P
A
-
L
Q
R
V
R
P
N
G
M
S
D
E
P
Q
Y
K
L
E
I
D
D
E
K
A
S
A
L
G
V
S
L
A
D
I
N
S
T
V
S
I
A
W
G
S
S
Y
V
N
D
F
I
D
R
G
--
R
V
K
R
V
Y
L
Q
G
R
P
D
A
R
M
N
P
D
D
L
S
K
W
Y
V
R
N
D
K
G
E
M
V
P
F
N
A
F
A
T
G
K
W
E
Y
G
S
P
K
L
E
R
Y
N
G
V
P
A
--
M
E
I
L
G
E
P
A
P
G
L
S
S
G
-
D
A
M
A
A
V
E
E
I
V
K
Q
L
P
K
G
V
G
---
Y
S
W
----
T
G
L
S
Y
E
E
--
R
L
S
G
-
Q
A
P
A
L
Y
A
L
S
L
L
V
V
F
L
C
L
A
A
L
Y
E
--
S
W
S
I
P
--
F
S
V
M
L
V
V
P
L
G
V
I
G
A
L
L
A
T
------
S
M
R
G
L
S
N
D
-----------
V
F
F
Q
-----------
V
G
L
L
T
T
I
G
L
S
----
A
K
N
A
I
L
I
V
E
-
F
A
K
E
-
L
H
E
Q
G
K
G
I
V
E
A
A
I
E
A
C
R
M
----
R
L
R
P
I
V
M
T
S
L
A
F
I
L
G
V
V
P
--------------
L
-----
A
-----
I
--
S
---
T
G
A
G
-----
S
G
S
Q
H
A
----
I
G
T
-----
G
V
I
G
G
M
V
T
A
T
V
L
A
I
F
W
V
P
L
F
Y
V
A
V
S
T
L
-----
32
Fugue
82.75
22%
-105
- C2 -
4MT1
-
?
A:
[2-1040]
-------
A
K
F
F
I
D
R
P
I
F
A
W
V
I
S
I
F
I
I
A
A
G
I
F
G
I
K
S
L
P
V
S
Q
Y
P
S
V
A
A
P
T
I
T
L
H
A
I
Y
P
G
A
S
A
Q
V
M
E
G
S
V
L
S
V
I
E
R
N
M
N
G
V
E
G
L
D
Y
M
S
-
T
S
A
D
S
-
S
-
G
S
G
S
V
-
S
L
T
F
T
P
D
T
---
D
E
N
L
A
-
Q
V
E
V
Q
--
N
K
L
S
E
V
L
S
T
L
P
A
T
V
Q
Q
Y
G
V
T
-----
V
-
S
-----
K
A
R
S
N
F
L
M
I
V
M
L
S
-------
S
D
--
V
--
Q
S
T
E
E
M
N
D
Y
-
A
-
Q
R
N
V
V
P
E
-
L
Q
R
I
E
G
V
G
Q
V
R
L
F
G
A
Q
-
R
A
-
M
R
I
W
V
D
P
K
K
L
Q
N
Y
N
L
S
F
A
D
V
G
S
A
L
S
A
Q
N
I
Q
I
S
A
G
S
I
G
----
S
L
P
----
A
------
V
RGQ
T
V
T
A
T
V
T
A
--
Q
G
Q
L
G
--
T
A
E
E
F
-
G
N
V
I
L
R
--
A
N
---
T
DG
S
N
I
--
Y
--
L
K
D
V
A
K
V
G
L
G
M
E
D
Y
S
---
S
S
T
R
L
N
G
V
N
T
T
-
G
M
A
V
M
L
S
N
S
G
N
A
M
A
T
A
K
A
V
K
E
R
L
A
V
L
E
K
Y
-
F
P
Q
G
M
S
W
K
T
P
Y
D
T
S
K
F
V
E
I
S
I
E
K
V
I
H
T
L
I
E
A
M
V
L
V
F
V
V
M
Y
L
F
L
Q
N
I
-
R
Y
T
L
I
P
T
I
V
V
P
I
S
L
L
G
G
F
A
F
I
S
Y
M
G
M
S
I
N
V
L
T
M
F
A
M
I
L
V
I
G
I
V
V
D
D
A
I
V
V
V
E
N
-
V
E
R
I
--
M
-
A
-
G
E
G
L
P
P
K
E
A
T
K
K
---------
A
M
G
Q
I
S
G
A
V
I
G
I
T
A
V
L
I
S
V
-----
F
V
P
L
----
A
M
F
S
G
A
A
G
N
I
Y
-
K
Q
F
A
L
-
T
M
A
S
S
I
A
F
S
A
F
L
A
L
T
L
T
P
A
L
C
A
-----
T
G
F
F
G
W
F
N
K
K
--------
F
D
S
W
T
---
H
G
-
Y
E
G
R
-----------
V
A
---------
K
V
L
R
K
T
F
R
M
M
V
V
Y
-
I
G
L
A
V
V
G
V
F
L
F
M
R
L
P
T
S
F
L
P
T
E
D
Q
G
F
V
M
V
S
V
Q
L
P
A
G
A
T
K
E
R
T
D
A
T
L
---
A
Q
V
T
Q
L
A
K
S
I
--
P
E
I
E
N
I
I
T
V
S
G
----------
F
S
-
F
S
G
S
G
Q
N
M
A
M
G
F
A
I
F
--
K
D
----------
W
N
E
R
TASGSD
A
V
---------
A
V
A
G
K
L
T
G
M
M
M
---
G
TLK
D
G
F
G
-----
I
A
V
V
--
P
P
P
I-
L
E
-----
L
G
-----
S
G
L
-----
S
I
N
L
----
Q
D
-
R
--
N
---
N
T
G
------------
H
T
A
L
L
A
K
R
N
E
L
-------
I
Q
K
M
R
A
S
G
L
F
D
-
P
S
T
V
R
A
G
G
L
E
D
S
P
Q
L
K
I
D
I
N
R
A
A
A
A
A
Q
G
I
S
F
A
D
I
R
T
A
L
A
S
A
L
S
S
S
Y
V
S
D
F
P
N
Q
G
--
R
L
Q
R
V
M
V
Q
A
D
E
D
A
R
M
Q
P
A
D
I
L
N
L
T
V
P
N
K
S
G
V
A
V
P
L
S
T
I
A
T
V
S
W
E
N
G
T
E
Q
S
V
R
F
N
G
Y
P
S
--
M
K
L
S
A
S
P
A
T
G
V
S
-----
T
G
Q
A
M
E
A
V
Q
K
M
V
D
E
L
G
---
G
G
Y
S
F
E
-
W
G
G
Q
S
S
E
--
E
-
A
K
G
G
S
Q
T
L
I
L
Y
G
L
A
V
A
A
V
F
L
V
L
A
A
L
--
Y
E
S
W
S
I
P
L
A
V
I
L
V
I
P
L
G
L
I
G
A
A
A
G
V
------
T
G
R
N
L
F
E
G
L
LGSVPSFAND
I
Y
F
Q
-----------
V
G
F
V
T
V
M
G
L
S
----
A
K
N
A
I
L
I
I
E
-
F
A
K
D
-
L
Q
A
Q
G
K
S
A
V
E
A
A
L
E
A
A
R
L
----
R
F
R
P
I
I
M
T
S
F
A
F
I
L
G
V
V
P
--------------
L
YIAAG
A
-----
S
--
S
---
A
S
Q
R
-----
A
---------
I
G
T
-----
T
V
F
W
G
M
L
V
G
T
L
L
S
V
F
L
V
P
L
F
Y
V
V
V
R
K
F
F
----
17
PsiBlast_PDB
82.37
23%
-98
- C2 -
2J8S
6
ACRB_ECOLI
A:
[11-1019]
----------------
F
A
W
V
I
A
I
I
I
M
L
A
G
G
L
A
I
L
K
L
P
V
A
Q
Y
P
T
I
A
P
P
A
V
T
I
S
A
S
Y
P
G
A
D
A
K
T
V
Q
D
T
V
T
Q
V
I
E
Q
N
M
N
G
I
D
N
L
M
Y
M
S
-
S
N
S
------
D
S
T
G
-
T
V
Q
I
T
L
T
F
E
S
G
T
D
A
D
I
A
Q
V
Q
V
Q
--
N
K
L
Q
L
A
M
P
L
L
P
Q
E
V
Q
Q
Q
G
V
S
-----
V
-
E
K
S
S
SS
F
L
-
M
V
V
G
V
I
---
N
-------
T
D
--
G
T-
M
T
Q
E
D
I
S
D
Y
-
V
-
A
A
-
N
M
K
D
A
I
S
R
T
S
G
V
G
D
V
Q
L
F
G
S
Q
Y
A
M
R
I
W
M
N
--
P
N
E
L
N
K
F
Q
L
T
P
V
D
V
I
T
A
I
K
A
Q
N
A
Q
V
A
A
G
Q
L
G
----
G
T
P
----
P
VKGQQ
L
N
------
A
S
I
I
A
--
Q
T
R
L
T
--
S
T
E
E
F
-
G
K
I
L
L
K
--
V
N
---
Q
--
D
G
S
--
R
V
L
L
R
D
V
A
K
I
E
L
G
G
E
N
Y
D
I
---
I
A
E
F
N
G
Q
P
A
S
-
G
L
G
I
K
L
A
T
G
A
N
A
L
D
T
A
A
A
I
R
A
E
L
A
K
M
E
P
F
-
F
P
S
G
L
K
I
V
Y
P
Y
D
T
T
P
F
V
K
I
S
I
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
-
R
A
T
L
I
P
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
-
N
V
E
R
V
--
M
-
A
-
E
E
G
L
--
P
P
K
E
A
------------
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
----
A
F
F
G
G
S
T
G
A
I
Y
-
R
Q
F
S
I
-
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
P
I
A
K
G
D
H
G
E
G
K
--------
K
G
F
F
G
W
F
N
R
M
-
F
E
K
S
-----------
T
H
H
Y
T
D
S
V
G
G
I
L
R
S
T
G
R
Y
L
V
L
Y
L
I
-
I
V
V
G
M
A
Y
L
F
V
R
--
L
P
S
S
F
L
P
D
E
D
Q
G
V
F
M
T
M
V
Q
L
P
A
G
A
T
Q
E
R
T
Q
K
V
L
---
N
E
V
T
H
Y
Y
L
T
K
--
E
K
N
N
V
E
S
V
F
A
V
---
N
G
-----
F
G
-
F
A
G
R
G
Q
N
T
--
G
I
A
F
V
S
L
K
D
WADRPGEENK
V
E
A
I
-------
T
---------
M
R
A
T
R
A
F
S
Q
I
K
---
D
---
A
M
V
F
-----
A
F
N
L
--
P
A
I
--
V
E
-----
L
G
-----
T
A
T
-----
G
F
D
F
----
E
L
I
D
-
Q
A
---
G
L
G
------------
H
E
K
L
T
Q
A
R
N
Q
L
-------
L
A
E
A
A
--
K
H
P
D
M
L
T
S
V
R
P
N
G
L
E
D
T
P
Q
F
K
I
D
I
D
Q
E
K
A
Q
A
L
G
V
S
I
N
D
I
N
T
T
L
G
A
A
W
G
G
S
Y
V
N
D
F
I
D
R
G
--
R
V
K
K
V
Y
V
M
S
E
A
K
Y
R
M
L
P
D
D
I
G
D
W
Y
V
R
A
A
D
G
Q
M
V
P
F
S
A
F
S
S
S
R
W
E
Y
G
S
P
R
L
E
R
Y
N
G
L
P
S
--
M
E
I
----
L
G
Q
A
A
P
G
-
K
S
T
G
E
A
M
E
L
M
E
Q
L
A
S
K
L
P
---
T
G
V
G
Y
D
W
T
G
M
S
Y
Q
E
R
L
S
-
G
N
Q
A
P
S
L
Y
A
I
S
L
I
V
V
F
L
C
L
A
A
L
-----
Y
E
S
W
S
I
P
F
S
V
M
L
V
V
P
L
G
V
I
G
A
L
L
A
A
------
T
F
R
G
L
T
N
D
-----------
V
Y
F
Q
-----------
V
G
L
L
T
T
I
G
L
S
----
A
K
N
A
I
L
I
V
E
F
A
K
D
L
-
M
D
K
E
G
K
G
L
I
E
A
T
L
D
A
V
R
M
----
R
L
R
P
I
L
M
T
S
L
A
F
I
L
G
V
M
P
--------------
L
-----
V
-----
I
--
S
---
T
G
A
G
-----
S
---------
G
A
Q
N
A
V
G
T
G
V
M
G
G
M
V
T
A
T
V
L
A
I
F
F
V
P
V
F
F
V
V
V
R
R
R
F
S
R
K
N
7
PsiBlast_PDB
82.31
22%
-105
- C2 -
3KSS
1
CUSA_ECOLI
A:
[33-1043]
--------------------------
I
W
G
T
W
T
I
I
N
T
P
V
D
A
L
P
D
L
S
D
V
Q
V
I
I
K
T
S
Y
P
G
Q
A
P
Q
I
V
E
N
Q
V
T
Y
P
L
T
T
T
M
L
S
V
P
G
A
K
T
V
R
-
G
F
S
-
Q
-
F
-
G
D
S
Y
V
-
Y
V
I
F
E
D
G
T
D
P
-----
Y
-
W
A
R
S
R
V
L
E
Y
L
N
Q
V
Q
G
K
L
P
A
G
V
S
A
E
L
G
P
-----
D
-
A
-----
T
G
---
V
G
W
I
Y
E
Y
A
L
V
D
RSGK
H
D
--
L
--
A
D
L
R
S
L
Q
D
W
-
F
----
L
K
Y
E
-
L
K
T
I
P
D
V
A
E
V
A
S
V
G
G
V
V
K
E
-
Y
Q
V
V
I
D
P
Q
R
L
A
Q
Y
G
I
S
L
A
E
V
K
S
A
L
D
A
S
N
Q
E
A
G
G
S
S
I
E
----
L
A
E
----
A
------
E
------
Y
M
V
R
A
--
S
G
Y
L
Q
--
T
L
D
D
F
-
N
H
I
V
L
K
--
A
S
---
E
--
N
G
V
P
V
Y
--
L
R
D
V
A
K
V
Q
---
I
G
P
E
M
RR
G
I
A
E
L
N
G
E
G
E
V
A
G
G
V
V
I
L
R
S
G
K
N
A
R
E
V
I
A
A
V
K
D
K
L
E
T
L
K
S
S
-
L
P
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V
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V
T
T
Y
D
R
S
Q
L
I
D
R
A
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N
L
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G
K
L
L
E
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F
I
V
V
A
V
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A
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L
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H
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-
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S
A
L
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A
I
I
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L
P
L
G
L
C
I
A
F
I
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M
H
F
Q
G
L
N
A
N
I
M
S
L
G
G
I
A
I
A
V
G
A
M
V
D
A
A
I
V
M
I
E
N
A
H
K
R
L
--
E
-
E
-
W
Q
H
Q
--------K
T
R
W
Q
V
I
T
D
A
S
V
E
V
G
P
A
L
F
I
S
L
L
I
I
T
L
S
-----
F
I
P
I
FT
L
E
G
Q
E
G
R
L
F
G
P
L
A
-
F
T
K
T
Y
-
A
M
A
G
A
A
L
L
----
A
I
V
V
I
P
I
L
M
G
Y
-------------
P
--------
L
N
R
F
L
---
I
R
V
Y
H
P
L
-----------
L
L
---------
K
V
L
H
W
P
K
T
T
L
L
V
A
-
A
L
S
V
L
T
V
L
W
P
L
N
K
V
G
G
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F
L
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Q
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N
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D
L
L
Y
M
P
S
T
L
P
G
I
S
A
A
E
A
A
S
M
L
---
Q
K
T
D
K
L
I
M
S
V
--
P
E
V
A
R
V
F
G
K
T
G
---
K
A
----------
E
T
A
T
D
S
A
P
L
E
M
V
E
T
T
I
Q
----------
L
K
P
Q
-------
E
QWRPGMT
M
D
K
I
I
E
E
L
D
N
T
V
R
---
L
---
P
G
L
A
------
N
L
W
--
V
P
P
--
I
R
N
R
I
D
M
L
S
-----
T
G
I
-----
K
S
P
I
----
G
I
-
K
-
V
S
---
G
T
V
------------
L
A
D
I
D
A
M
A
E
Q
I
-------
E
E
V
A
R
--
T
V
P
G
-
V
A
S
A
L
A
E
R
L
E
G
G
R
Y
I
N
V
E
I
N
R
E
K
A
A
R
Y
G
M
T
V
A
D
V
Q
L
F
V
T
S
A
V
G
G
A
M
V
G
E
T
V
E
G
I
A
R
Y
P
I
N
L
--
R
Y
P
Q
S
W
R
D
S
P
Q
A
L
R
Q
L
P
I
L
T
P
M
K
Q
Q
I
T
L
A
D
V
A
D
I
K
V
S
T
G
P
S
M
L
K
T
E
N
A
R
P
T
S
W
I
Y
I
D
A
R
D
R
D
M
V
S
V
V
H
D
L
Q
K
A
I
A
E
K
V
Q
-----
L
K
---
P
G
T
S
V
A
-
F
S
G
Q
F
E
L
--
L
-
E
R
A
N
H
K
L
K
L
M
V
P
M
T
L
M
I
I
F
V
L
L
Y
L
A
--
F
R
R
V
G
E
A
L
L
I
I
S
S
V
P
F
A
L
V
G
G
I
W
L
L
W
WMGFH
L
S
V
A
T
G
T
G
-----------
F
I
A
L
-----------
A
G
V
A
A
E
F
G
V
V
M
L
M
Y
L
R
H
A
I
E
A
V
P
-
S
L
N
N
-
P
Q
T
F
S
E
---
Q
K
L
D
E
A
L
Y
H
G
A
V
L
R
V
R
P
K
A
M
T
V
A
V
I
I
A
G
L
L
P
--------------
I
-------------------
L
W
G
-----
T
GAGSEV
M
S
R
I
A
A
-----
P
M
I
G
G
M
I
T
A
P
L
L
S
L
F
I
I
P
A
A
Y
K
L
M
W
-------
10
PsiBlast_PDB
82.19
23%
-97
- C2 -
3D9B
1
ACRB_ECOLI
A:
[11-1019]
----------------
F
A
W
V
I
A
I
I
I
M
L
A
G
G
L
A
I
L
K
L
P
V
A
Q
Y
P
T
I
A
P
P
A
V
T
I
S
A
S
Y
P
G
A
D
A
K
T
V
Q
D
T
V
T
Q
V
I
E
Q
N
M
N
G
I
D
N
L
M
Y
M
S
-
S
N
S
------
D
S
T
G
-
T
V
Q
I
T
L
T
F
E
S
G
T
D
A
D
I
A
Q
V
Q
V
Q
--
N
K
L
Q
L
A
M
P
L
L
P
Q
E
V
Q
Q
Q
G
V
S
-----
V
-
E
K
S
S
SS
F
L
-
M
V
V
G
V
I
---
N
-------
T
D
--
G
T-
M
T
Q
E
D
I
S
D
Y
-
V
-
A
A
-
N
M
K
D
A
I
S
R
T
S
G
V
G
D
V
Q
L
F
G
S
Q
Y
A
M
R
I
W
M
N
--
P
N
E
L
N
K
F
Q
L
T
P
V
D
V
I
T
A
I
K
A
Q
N
A
Q
V
A
A
G
Q
L
G
----
G
T
P
----
P
VKGQQ
L
N
------
A
S
I
I
A
--
Q
T
R
L
T
--
S
T
E
E
F
-
G
K
I
L
L
K
--
V
N
---
Q
--
D
G
S
--
R
V
L
L
R
D
V
A
K
I
E
L
G
G
E
N
Y
D
I
---
I
A
E
F
N
G
Q
P
A
S
-
G
L
G
I
K
L
A
T
G
A
N
A
L
D
T
A
A
A
I
R
A
E
L
A
K
M
E
P
F
-
F
P
S
G
L
K
I
V
Y
P
Y
D
T
T
P
F
V
K
I
S
I
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
-
R
A
T
L
I
P
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
-
N
V
E
R
V
--
M
-
A
-
E
E
G
L
--
P
P
K
E
A
------------
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
----
A
F
F
G
G
S
T
G
A
I
Y
-
R
Q
F
S
I
-
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
P
I
A
K
G
D
H
G
E
G
K
--------
K
G
F
F
G
W
F
N
R
M
-
F
E
K
S
-----------
T
H
H
Y
T
D
S
V
G
G
I
L
R
S
T
G
R
Y
L
V
L
Y
L
I
-
I
V
V
G
M
A
Y
L
F
V
R
--
L
P
S
S
F
L
P
D
E
D
Q
G
V
F
M
T
M
V
Q
L
P
A
G
A
T
Q
E
R
T
Q
K
V
L
---
N
E
V
T
H
Y
Y
L
T
K
--
E
K
N
N
V
E
S
V
F
A
V
---
N
G
-----
F
G
-
F
A
G
R
G
Q
N
T
--
G
I
A
F
V
S
L
K
D
WADRPGEENK
V
E
A
I
-------
T
---------
M
R
A
T
R
A
F
S
Q
I
K
---
D
---
A
M
V
F
-----
A
F
N
L
--
P
A
I
--
V
E
-----
L
G
-----
T
A
T
-----
G
F
D
F
----
E
L
I
D
-
Q
A
---
G
L
G
------------
H
E
K
L
T
Q
A
R
N
Q
L
-------
L
A
E
A
A
--
K
H
P
D
M
L
T
S
V
R
P
N
G
L
E
D
T
P
Q
F
K
I
D
I
D
Q
E
K
A
Q
A
L
G
V
S
I
N
D
I
N
T
T
L
G
A
A
W
G
G
S
Y
V
N
D
F
I
D
R
G
--
R
V
K
K
V
Y
V
M
S
E
A
K
Y
R
M
L
P
D
D
I
G
D
W
Y
V
R
A
A
D
G
Q
M
V
P
F
S
A
F
S
S
S
R
W
E
Y
G
S
P
R
L
E
R
Y
N
G
L
P
S
--
M
E
I
----
L
G
Q
A
A
P
G
-
K
S
T
G
E
A
M
E
L
M
E
Q
L
A
S
K
L
P
---
T
G
V
G
Y
D
W
T
G
M
S
Y
Q
E
R
L
S
-
G
N
Q
A
P
S
L
Y
A
I
S
L
I
V
V
F
L
C
L
A
A
L
-----
Y
E
S
W
S
I
P
F
S
V
M
L
V
V
P
L
G
V
I
G
A
L
L
A
A
------
T
F
R
G
L
T
N
D
-----------
V
Y
F
Q
-----------
V
G
L
L
T
T
I
G
L
S
----
A
K
N
A
I
L
I
V
E
F
A
K
D
L
-
M
D
K
E
G
K
G
L
I
E
A
T
L
D
A
V
R
M
----
R
L
R
P
I
L
M
T
S
L
A
F
I
L
G
V
M
P
--------------
L
-----
V
-----
I
--
S
---
T
G
A
G
-----
S
---------
G
A
Q
N
A
V
G
T
G
V
M
G
G
M
V
T
A
T
V
L
A
I
F
F
V
P
V
F
F
V
V
V
R
R
R
F
S
R
K
N
14
PsiBlast_PDB
82.09
23%
-98
- C2 -
2HRT
2
ACRB_ECOLI
A:
[11-1019]
----------------
F
A
W
V
I
A
I
I
I
M
L
A
G
G
L
A
I
L
K
L
P
V
A
Q
Y
P
T
I
A
P
P
A
V
T
I
S
A
S
Y
P
G
A
D
A
K
T
V
Q
D
T
V
T
Q
V
I
E
Q
N
M
N
G
I
D
N
L
M
Y
M
S
-
S
N
S
------
D
S
T
G
-
T
V
Q
I
T
L
T
F
E
S
G
T
D
A
D
I
A
Q
V
Q
V
Q
--
N
K
L
Q
L
A
M
P
L
L
P
Q
E
V
Q
Q
Q
G
V
S
-----
V
-
E
KSSSS
F
L
-
M
V
V
G
V
I
---
N
-------
T
D
--
G
T-
M
T
Q
E
D
I
S
D
Y
-
V
-
A
A
-
N
M
K
D
A
I
S
R
T
S
G
V
G
D
V
Q
L
F
G
S
Q
Y
A
M
R
I
W
M
N
--
P
N
E
L
N
K
F
Q
L
T
P
V
D
V
I
T
A
I
K
A
Q
N
A
Q
V
A
A
G
Q
L
G
----
G
T
P
----
P
VKGQQ
L
N
------
A
S
I
I
A
--
Q
T
R
L
T
--
S
T
E
E
F
-
G
K
I
L
L
K
--
V
N
---
Q
--
D
G
S
--
R
V
L
L
R
D
V
A
K
I
E
L
G
G
E
N
Y
D
I
---
I
A
E
F
N
G
Q
P
A
S
-
G
L
G
I
K
L
A
T
G
A
N
A
L
D
T
A
A
A
I
R
A
E
L
A
K
M
E
P
F
-
F
P
S
G
L
K
I
V
Y
P
Y
D
T
T
P
F
V
K
I
S
I
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
-
R
A
T
L
I
P
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
-
N
V
E
R
V
--
M
-
A
-
E
E
G
L
--
P
P
K
E
A
------------
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
----
A
F
F
G
G
S
T
G
A
I
Y
-
R
Q
F
S
I
-
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
P
I
A
K
G
D
H
G
E
G
K
--------
K
G
F
F
G
W
F
N
R
M
-
F
E
K
S
-----------
T
H
H
Y
T
D
S
V
G
G
I
L
R
S
T
G
R
Y
L
V
L
Y
L
I
-
I
V
V
G
M
A
Y
L
F
V
R
--
L
P
S
S
F
L
P
D
E
D
Q
G
V
F
M
T
M
V
Q
L
P
A
G
A
T
Q
E
R
T
Q
K
V
L
---
N
E
V
T
H
Y
Y
L
T
K
--
E
K
N
N
V
E
S
V
F
A
V
---
N
G
-----
F
G
-
F
A
G
R
G
Q
N
T
--
G
I
A
F
V
S
L
K
D
WADRPGEENK
V
E
A
I
-------
T
---------
M
R
A
T
R
A
F
S
Q
I
K
---
D
---
A
M
V
F
-----
A
F
N
L
--
P
A
I
--
V
E
-----
L
G
-----
T
A
T
-----
G
F
D
F
----
E
L
I
D
-
Q
A
---
G
L
G
------------
H
E
K
L
T
Q
A
R
N
Q
L
-------
L
A
E
A
A
--
K
H
P
D
M
L
T
S
V
R
P
N
G
L
E
D
T
P
Q
F
K
I
D
I
D
Q
E
K
A
Q
A
L
G
V
S
I
N
D
I
N
T
T
L
G
A
A
W
G
G
S
Y
V
N
D
F
I
D
R
G
--
R
V
K
K
V
Y
V
M
S
E
A
K
Y
R
M
L
P
D
D
I
G
D
W
Y
V
R
A
A
D
G
Q
M
V
P
F
S
A
F
S
S
S
R
W
E
Y
G
S
P
R
L
E
R
Y
N
G
L
P
S
--
M
E
I
----
L
G
Q
A
A
P
G
-
K
S
T
G
E
A
M
E
L
M
E
Q
L
A
S
K
L
P
---
T
G
V
G
Y
D
W
T
G
M
S
Y
Q
E
R
L
S
-
G
N
Q
A
P
S
L
Y
A
I
S
L
I
V
V
F
L
C
L
A
A
L
-----
Y
E
S
W
S
I
P
F
S
V
M
L
V
V
P
L
G
V
I
G
A
L
L
A
A
------
T
F
R
G
L
T
N
D
-----------
V
Y
F
Q
-----------
V
G
L
L
T
T
I
G
L
S
----
A
K
N
A
I
L
I
V
E
F
A
K
D
L
-
M
D
K
E
G
K
G
L
I
E
A
T
L
D
A
V
R
M
----
R
L
R
P
I
L
M
T
S
L
A
F
I
L
G
V
M
P
--------------
L
-----
V
-----
I
--
S
---
T
G
A
G
-----
S
---------
G
A
Q
N
A
V
G
T
G
V
M
G
G
M
V
T
A
T
V
L
A
I
F
F
V
P
V
F
F
V
V
V
R
R
R
F
----
18
PsiBlast_PDB
82.04
23%
-96
- C2 -
4DX6
4
ACRB_ECOLI
A:
[11-1019]
----------------
F
A
W
V
I
A
I
I
I
M
L
A
G
G
L
A
I
L
K
L
P
V
A
Q
Y
P
T
I
A
P
P
A
V
T
I
S
A
S
Y
P
G
A
D
A
K
T
V
Q
D
T
V
T
Q
V
I
E
Q
N
M
N
G
I
D
N
L
M
Y
M
S
-
S
N
S
------
D
S
T
G
-
T
V
Q
I
T
L
T
F
E
S
G
T
D
A
D
I
A
Q
V
Q
V
Q
--
N
K
L
Q
L
A
M
P
L
L
P
Q
E
V
Q
Q
Q
G
V
S
-----
V
-
E
KSSSS
F
L
-
M
V
V
G
V
I
---
N
-------
T
D
--
G
T-
M
T
Q
E
D
I
S
D
Y
-
V
-
A
A
-
N
M
K
D
A
I
S
R
T
S
G
V
G
D
V
Q
L
F
G
S
Q
Y
A
M
R
I
W
M
N
--
P
N
E
L
N
K
F
Q
L
T
P
V
D
V
I
T
A
I
K
A
Q
N
A
Q
V
A
A
G
Q
L
G
----
G
T
P
----
P
VKGQQ
L
N
------
A
S
I
I
A
--
Q
T
R
L
T
--
S
T
E
E
F
-
G
K
I
L
L
K
--
V
N
---
Q
--
D
G
S
--
R
V
L
L
R
D
V
A
K
I
E
L
G
G
E
N
Y
D
I
---
I
A
E
F
N
G
Q
P
A
S
-
G
L
G
I
K
L
A
T
G
A
N
A
L
D
T
A
A
A
I
R
A
E
L
A
K
M
E
P
F
-
F
P
S
G
L
K
I
V
Y
P
Y
D
T
T
P
F
V
K
I
S
I
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
-
R
A
T
L
I
P
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
-
N
V
E
R
V
--
M
-
A
-
E
E
G
L
--
P
P
K
E
A
------------
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
----
A
F
F
G
G
S
T
G
A
I
Y
-
R
Q
F
S
I
-
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
P
I
A
K
G
D
H
G
E
G
K
--------
K
G
F
F
G
W
F
N
R
M
-
F
E
K
S
-----------
T
H
H
Y
T
D
S
V
G
G
I
L
R
S
T
G
R
Y
L
V
L
Y
L
I
-
I
V
V
G
M
A
Y
L
F
V
R
--
L
P
S
S
F
L
P
D
E
D
Q
G
V
F
M
T
M
V
Q
L
P
A
G
A
T
Q
E
R
T
Q
K
V
L
---
N
E
V
T
H
Y
Y
L
T
K
--
E
K
N
N
V
E
S
V
F
A
V
---
N
G
-----
F
N
-
F
A
G
R
G
Q
N
T
--
G
I
A
F
V
S
L
K
D
WADRPGEENK
V
E
A
I
-------
T
---------
M
R
A
T
R
A
F
S
Q
I
K
---
D
---
A
M
V
F
-----
A
F
N
L
--
P
A
I
--
V
E
-----
L
G
-----
T
A
T
-----
G
F
D
F
----
E
L
I
D
-
Q
A
---
G
L
G
------------
H
E
K
L
T
Q
A
R
N
Q
L
-------
L
A
E
A
A
--
K
H
P
D
M
L
T
S
V
R
P
N
G
L
E
D
T
P
Q
F
K
I
D
I
D
Q
E
K
A
Q
A
L
G
V
S
I
N
D
I
N
T
T
L
G
A
A
W
G
G
S
Y
V
N
D
F
I
D
R
G
--
R
V
K
K
V
Y
V
M
S
E
A
K
Y
R
M
L
P
D
D
I
G
D
W
Y
V
R
A
A
D
G
Q
M
V
P
F
S
A
F
S
S
S
R
W
E
Y
G
S
P
R
L
E
R
Y
N
G
L
P
S
--
M
E
I
----
L
G
Q
A
A
P
G
-
K
S
T
G
E
A
M
E
L
M
E
Q
L
A
S
K
L
P
---
T
G
V
G
Y
D
W
T
G
M
S
Y
Q
E
RL
S
-
G
N
Q
A
P
S
L
Y
A
I
S
L
I
V
V
F
L
C
L
A
A
L
-----
Y
E
S
W
S
I
P
F
S
V
M
L
V
V
P
L
G
V
I
G
A
L
L
A
A
------
T
F
R
G
L
T
N
D
-----------
V
Y
F
Q
-----------
V
G
L
L
T
T
I
G
L
S
----
A
K
N
A
I
L
I
V
E
F
A
K
D
L
-
M
D
K
E
G
K
G
L
I
E
A
T
L
D
A
V
R
M
----
R
L
R
P
I
L
M
T
S
L
A
F
I
L
G
V
M
P
--------------
L
-----
V
-----
I
--
S
---
T
G
A
G
-----
S
---------
G
A
Q
N
A
V
G
T
G
V
M
G
G
M
V
T
A
T
V
L
A
I
F
F
V
P
V
F
F
V
V
V
R
R
R
F
S
R
K
N
2
PsiBlast_PDB
82.00
23%
-101
- C2 -
2V50
2
MEXB_PSEAE
A:
[4-1025]
---------
F
F
I
D
R
P
I
F
A
W
V
I
A
L
V
I
M
L
A
G
G
L
S
I
L
S
L
P
V
N
Q
Y
P
A
I
A
P
P
A
I
A
V
Q
V
S
Y
P
G
A
S
A
E
T
V
Q
D
T
V
V
Q
V
I
E
Q
Q
M
N
G
I
D
N
L
R
Y
I
S
-
S
E
S
-
N
-
S
D
G
S
M
T
I
-
T
V
----
T
F
E
Q
G
T
D
P
D
I
A
Q
V
Q
V
Q
--
N
K
L
Q
L
A
T
P
L
L
P
Q
E
V
Q
R
Q
G
I
R
V
T
KAV
K
-
N
-----
F
L
-
M
V
V
G
V
V
---
S
-------
T
D
--
G
S-
M
T
K
E
D
L
S
N
Y
I
V
-
S
N
-
I
Q
D
P
-
L
S
R
T
K
G
V
G
D
F
Q
V
F
G
S
Q
Y
S
M
R
I
W
L
D
--
P
A
K
L
N
S
Y
Q
L
T
P
G
D
V
S
S
A
I
Q
A
Q
N
V
Q
I
S
S
G
Q
L
G
----
G
L
P
AVKG
Q
------
Q
------
L
N
A
T
I
--
I
G
K
T
R
L
Q
T
A
E
Q
F
-
E
N
I
L
L
K
--
V
N
PD-
G
--
S
Q
V
--
R
--
L
K
D
V
A
D
V
G
L
G
G
Q
D
Y
S
I
--
N
A
-
Q
F
N
G
S
P
A
S
-
G
I
A
I
K
L
A
T
G
A
N
A
L
D
T
A
K
A
I
R
Q
T
I
A
N
L
E
P
F
-
M
P
Q
G
M
K
V
V
Y
P
Y
D
T
T
P
V
V
S
A
S
I
H
E
V
V
K
T
L
G
E
A
I
L
L
V
F
L
V
M
Y
L
F
L
Q
N
F
-
R
A
T
L
I
P
T
I
A
V
P
V
V
L
L
G
T
F
G
V
L
A
A
F
G
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
-
N
V
E
R
V
M
A
E
-
E
-
G
L
S
P
--
R
E
A
A
R
K
---------
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
-----
F
L
P
M
----
A
F
F
G
G
S
T
G
V
I
Y
-
R
Q
F
S
I
-
T
I
V
S
A
M
A
L
S
V
I
V
A
L
I
L
T
P
A
L
C
A
T
M
L
-
K
P
--------------------
F
F
---
G
W
-
F
N
R
M
F
L
S
T
T
H
G
Y
E
R
G
V
A
---------
S
I
L
K
H
R
A
P
Y
L
L
I
Y
-
V
V
I
V
A
G
M
I
W
M
F
T
R
I
P
T
A
F
L
P
D
E
D
Q
G
V
L
F
A
Q
V
Q
T
P
P
G
S
S
A
E
R
T
Q
V
V
V
---
D
S
M
R
E
Y
L
L
E
K
--
E
S
S
S
V
S
S
V
F
T
V
---
T
G
--------
F
N
F
A
G
R
G
Q
S
S
G
M
A
F
I
M
L
K
P
----------
W
E
E
R
PGG----
E
---------
N
S
V
F
E
L
A
K
R
A
Q
---
M
---
H
F
F
S
FKD
A
M
V
F
A
F
--
A
P
P
SV
L
---------------
T
-----
G
F
D
L
F
L
Q
D
Q
A
-
G
-
V
G
---
H
E
V
------------
L
L
Q
A
R
N
K
F
L
M
L
-------
A
A
-----
Q
N
P
A
-
L
Q
R
V
R
P
N
G
M
S
D
E
P
Q
Y
K
L
E
I
D
D
E
K
A
S
A
L
G
V
S
L
A
D
I
N
S
T
V
S
I
A
W
G
S
S
Y
V
N
D
F
I
D
R
G
--
R
V
K
R
V
Y
L
Q
G
R
P
D
A
R
M
N
P
D
D
L
S
K
W
Y
V
R
N
D
K
G
E
M
V
P
F
N
A
F
A
T
G
K
W
E
Y
G
S
P
K
L
E
R
Y
N
G
V
P
A
--
M
E
I
L
G
E
P
A
P
G
L
S
S
G
-
D
A
M
A
A
V
E
E
I
V
K
Q
L
P
K
G
V
G
---
Y
S
W
----
T
G
L
S
Y
E
E
--
R
L
S
G
S
Q
A
P
A
L
Y
A
L
S
L
L
V
V
F
L
C
L
A
A
L
Y
E
--
S
W
S
I
P
--
F
S
V
M
L
V
V
P
L
G
V
I
G
A
L
L
A
T
------
S
M
R
G
L
S
N
D
-----------
V
F
F
Q
-----------
V
G
L
L
T
T
I
G
L
S
----
A
K
N
A
I
L
I
V
E
-
F
A
K
E
-
L
H
E
Q
G
K
G
I
V
E
A
A
I
E
A
C
R
M
----
R
L
R
P
I
V
M
T
S
L
A
F
I
L
G
V
V
P
--------------
L
-----
A
-----
I
--
S
---
T
G
A
G
-----
S
G
S
Q
H
A
----
I
G
T
-----
G
V
I
G
G
M
V
T
A
T
V
L
A
I
F
W
V
P
L
F
Y
V
----------
13
PsiBlast_PDB
81.75
23%
-97
- C2 -
2GIF
2
ACRB_ECOLI
A:
[11-1019]
----------------
F
A
W
V
I
A
I
I
I
M
L
A
G
G
L
A
I
L
K
L
P
V
A
Q
Y
P
T
I
A
P
P
A
V
T
I
S
A
S
Y
P
G
A
D
A
K
T
V
Q
D
T
V
T
Q
V
I
E
Q
N
M
N
G
I
D
N
L
M
Y
M
S
-
S
N
S
------
D
S
T
G
-
T
V
Q
I
T
L
T
F
E
S
G
T
D
A
D
I
A
Q
V
Q
V
Q
--
N
K
L
Q
L
A
M
P
L
L
P
Q
E
V
Q
Q
Q
G
V
S
-----
V
-
E
KSSSS
F
L
-
M
V
V
G
V
I
---
N
-------
T
D
--
G
T-
M
T
Q
E
D
I
S
D
Y
-
V
-
A
A
-
N
M
K
D
A
I
S
R
T
S
G
V
G
D
V
Q
L
F
G
S
Q
Y
A
M
R
I
W
M
N
--
P
N
E
L
N
K
F
Q
L
T
P
V
D
V
I
T
A
I
K
A
Q
N
A
Q
V
A
A
G
Q
L
G
----
G
T
P
----
P
VKGQQ
L
N
------
A
S
I
I
A
--
Q
T
R
L
T
--
S
T
E
E
F
-
G
K
I
L
L
K
--
V
N
---
Q
--
D
G
S
--
R
V
L
L
R
D
V
A
K
I
E
L
G
G
E
N
Y
D
I
---
I
A
E
F
N
G
Q
P
A
S
-
G
L
G
I
K
L
A
T
G
A
N
A
L
D
T
A
A
A
I
R
A
E
L
A
K
M
E
P
F
-
F
P
S
G
L
K
I
V
Y
P
Y
D
T
T
P
F
V
K
I
S
I
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
-
R
A
T
L
I
P
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
-
N
V
E
R
V
--
M
-
A
-
E
E
G
L
--
P
P
K
E
A
------------
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
----
A
F
F
G
G
S
T
G
A
I
Y
-
R
Q
F
S
I
-
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
P
I
A
K
G
D
H
G
E
G
K
--------
K
G
F
F
G
W
F
N
R
M
-
F
E
K
S
-----------
T
H
H
Y
T
D
S
V
G
G
I
L
R
S
T
G
R
Y
L
V
L
Y
L
I
-
I
V
V
G
M
A
Y
L
F
V
R
--
L
P
S
S
F
L
P
D
E
D
Q
G
V
F
M
T
M
V
Q
L
P
A
G
A
T
Q
E
R
T
Q
K
V
L
---
N
E
V
T
H
Y
Y
L
T
K
--
E
K
N
N
V
E
S
V
F
A
V
---
N
G
-----
F
G
-
F
A
G
R
G
Q
N
T
--
G
I
A
F
V
S
L
K
D
WADRPGEENK
V
E
A
I
-------
T
---------
M
R
A
T
R
A
F
S
Q
I
K
---
D
---
A
M
V
F
-----
A
F
N
L
--
P
A
I
--
V
E
-----
L
G
-----
T
A
T
-----
G
F
D
F
----
E
L
I
D
-
Q
A
---
G
L
G
------------
H
E
K
L
T
Q
A
R
N
Q
L
-------
L
A
E
A
A
--
K
H
P
D
M
L
T
S
V
R
P
N
G
L
E
D
T
P
Q
F
K
I
D
I
D
Q
E
K
A
Q
A
L
G
V
S
I
N
D
I
N
T
T
L
G
A
A
W
G
G
S
Y
V
N
D
F
I
D
R
G
--
R
V
K
K
V
Y
V
M
S
E
A
K
Y
R
M
L
P
D
D
I
G
D
W
Y
V
R
A
A
D
G
Q
M
V
P
F
S
A
F
S
S
S
R
W
E
Y
G
S
P
R
L
E
R
Y
N
G
L
P
S
--
M
E
I
----
L
G
Q
A
A
P
G
-
K
S
T
G
E
A
M
E
L
M
E
Q
L
A
S
K
L
P
---
T
G
V
G
Y
D
W
T
G
M
S
Y
Q
E
R
L
S
-
G
N
Q
A
P
S
L
Y
A
I
S
L
I
V
V
F
L
C
L
A
A
L
-----
Y
E
S
W
S
I
P
F
S
V
M
L
V
V
P
L
G
V
I
G
A
L
L
A
A
------
T
F
R
G
L
T
N
D
-----------
V
Y
F
Q
-----------
V
G
L
L
T
T
I
G
L
S
----
A
K
N
A
I
L
I
V
E
F
A
K
D
L
-
M
D
K
E
G
K
G
L
I
E
A
T
L
D
A
V
R
M
----
R
L
R
P
I
L
M
T
S
L
A
F
I
L
G
V
M
P
--------------
L
-----
V
-----
I
--
S
---
T
G
A
G
-----
S
---------
G
A
Q
N
A
V
G
T
G
V
M
G
G
M
V
T
A
T
V
L
A
I
F
F
V
P
V
F
F
V
V
V
R
R
R
F
----
22
HHSearch
81.62
22%
-108
* C2 *
3W9I
5
MEXB_PSEAE
A:
[1-1030]
------
M
S
K
F
F
I
D
R
P
I
F
A
W
V
I
A
L
V
I
M
L
A
G
G
L
S
I
L
S
L
P
V
N
Q
Y
P
A
I
A
P
P
A
I
A
V
Q
V
S
Y
P
G
A
S
A
E
T
V
Q
D
T
V
V
Q
V
I
E
Q
Q
M
N
G
I
D
N
L
R
Y
I
S
-
S
E
S
N
S
-
D
-
G
S
M
T
I
-
T
V
T
F
E
Q
G
T
D
---
P
D
I
A
-
Q
V
Q
V
Q
--
N
K
L
Q
L
A
T
P
L
L
P
Q
E
V
Q
R
Q
G
I
R
-----
V
T
K
-----
A
V
-
K
N
F
L
M
V
V
G
V
V
-------
S
T
--
D
GS
M
T
K
E
D
L
S
N
Y
I
V
-
S
N
-
I
Q
D
P
-
L
S
R
T
K
G
V
G
D
F
Q
V
F
G
S
-
Q
Y
S
-
M
R
I
W
L
D
P
A
K
L
N
S
Y
Q
L
T
P
G
D
V
S
S
A
I
Q
A
Q
N
V
Q
I
S
S
G
Q
L
G
GLPA
V
K
G
----
Q
------
Q
------
L
N
A
T
I
I
G
K
T
R
L
Q
--
T
A
E
Q
F
-
E
N
I
L
L
K
VN
P
D
---
G
--
S
Q
V
--
R
--
L
K
D
V
A
D
V
G
L
G
G
Q
-
D
Y
S
--
I
N
A
Q
F
N
G
S
P
A
S
-
G
I
A
I
K
L
A
T
G
A
N
A
L
D
T
A
K
A
I
R
Q
T
I
A
N
L
E
P
F
-
M
P
Q
G
M
K
V
V
Y
P
Y
D
T
T
P
V
V
S
A
S
I
H
E
V
V
K
T
L
G
E
A
I
L
L
V
F
L
V
M
Y
L
F
L
Q
N
F
-
R
A
T
L
I
P
T
I
A
V
P
V
V
L
L
G
T
F
G
V
L
A
A
F
G
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
N
V
E
R
V
M
--
A
E
E
-
G
L
S
P
--
R
E
A
A
R
K
---------
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
-----
F
L
P
M
----
A
F
F
G
G
S
T
G
V
I
Y
-
R
Q
F
S
I
-
T
I
V
S
A
M
A
L
S
V
I
V
A
L
I
L
T
P
A
L
C
A
T
M
L
-
K
P
---------F
F
G
W
F
N
R
M
F
L
S
T
T
---
H
G
-
Y
E
R
G
-----------
V
A
---------
S
I
L
K
H
R
A
P
Y
L
L
I
Y
-
V
V
I
V
A
G
M
I
W
M
F
T
R
I
P
T
A
F
L
P
D
E
D
Q
G
V
L
F
A
Q
V
Q
T
P
P
G
S
S
A
E
R
T
Q
V
V
V
---
D
S
M
R
E
Y
L
L
E
K
ES
S
S
V
S
S
V
F
T
V
T
G
---
F
N
F
A
----------
G
R
G
Q
S
S
G
M
A
F
I
M
L
K
P
----------
W
E
E
R
PGGENSV
F
---------
E
L
A
K
R
A
Q
M
H
F
F
-------
S
F
K
D
-----
A
M
V
F
A
F
A
P
P
SV
L
E
-----
L
G
-----
N
A
T
-----
G
F
D
L
----
F
L
-
Q
D
Q
A
---
G
V
G
------------
H
E
V
L
L
Q
A
R
N
K
F
-------
L
M
L
A
A
--
Q
N
P
A
-
L
Q
R
V
R
P
N
G
M
S
D
E
P
Q
Y
K
L
E
I
D
D
E
K
A
S
A
L
G
V
S
L
A
D
I
N
S
T
V
S
I
A
W
G
S
S
Y
V
N
D
F
I
D
R
G
--
R
V
K
R
V
Y
L
Q
G
R
P
D
A
R
M
N
P
D
D
L
S
K
W
Y
V
R
N
D
K
G
E
M
V
P
F
N
A
F
A
T
G
K
W
E
Y
G
S
P
K
L
E
R
Y
N
G
V
P
A
--
M
E
I
L
G
E
P
A
P
G
L
S
S
G
-
D
A
M
A
A
V
E
E
I
V
K
----
Q
L
P
---
K
G
V
G
Y
S
-
W
T
G
L
S
Y
E
--
E
-
R
L
S
G
-
Q
A
P
A
L
Y
A
L
S
L
L
V
V
F
L
C
L
A
A
L
--
Y
E
S
W
S
I
P
F
S
V
M
L
V
V
P
L
G
V
I
G
A
L
L
A
T
------
S
M
R
G
L
S
N
D
-----------
V
F
F
Q
-----------
V
G
L
L
T
T
I
G
L
S
----
A
K
N
A
I
L
I
V
E
-
F
A
K
E
-
L
H
E
Q
G
K
G
I
V
E
A
A
I
E
A
C
R
M
----
R
L
R
P
I
V
M
T
S
L
A
F
I
L
G
V
V
P
--------------
L
-----
A
-----
I
S
T
G
A
G
S
G
S
Q
H
-----
A
---------
I
G
T
-----
G
V
I
G
G
M
V
T
A
T
V
L
A
I
F
W
V
P
L
F
Y
V
A
V
S
T
L
-----
31
Fugue
80.76
21%
-105
- C2 -
1IWG
-
ACRB_ECOLI
A:
[7-1036]
------------
D
R
P
I
F
A
W
V
I
A
I
I
I
M
L
A
G
G
L
A
I
L
K
L
P
V
A
Q
Y
P
T
I
A
P
P
A
V
T
I
S
A
S
Y
P
G
A
D
A
K
T
V
Q
D
T
V
T
Q
V
I
E
Q
N
M
N
G
I
D
N
L
M
Y
M
S
-
S
N
S
-
D
S
T
-
G
T
V
Q
I
-
T
L
T
F
E
S
G
T
---
D
A
D
I
A
-
Q
V
Q
V
Q
--
N
K
L
Q
L
A
M
P
L
L
P
Q
E
V
Q
Q
Q
G
V
S
-----
V
-
E
-----
K
S
S
S
S
F
L
M
V
V
G
V
I
-------
N
T
DG
T
--
M
T
Q
E
D
I
S
D
Y
-
V
A
A
N
-
M
K
D
A
-
I
S
R
T
S
G
V
G
D
V
Q
L
F
G
-
S
Q
Y
A
-
M
R
I
W
M
N
P
N
E
L
N
K
F
Q
L
T
P
V
D
V
I
T
A
I
K
A
Q
N
A
Q
V
A
A
G
Q
L
G
----
G
T
P
----
P
VKGQQ
L
N
------
A
S
I
I
A
--
Q
T
R
L
T
--
S
T
E
E
F
-
G
K
I
L
L
K
--
V
N
---
Q
DG
S
R
V
--
L
--
L
R
D
V
A
K
I
E
L
G
G
E
N
Y
-
D
--
I
I
A
E
F
N
G
Q
P
A
S
-
G
L
G
I
K
L
A
T
G
A
N
A
L
D
T
A
A
A
I
R
A
E
L
A
K
M
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P
F
-
F
P
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G
L
K
I
V
Y
P
Y
D
T
T
P
F
V
K
I
S
I
H
E
V
V
K
T
L
V
E
A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
-
R
A
T
L
I
P
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
N
V
E
R
V
M
--
A
-
E
E
G
L
P
P
--
K
E
A
T
R
K
---------
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
-----
F
V
P
M
----
A
F
F
G
G
S
T
G
A
I
Y
-
R
Q
F
S
I
-
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
-
K
F
---
G
W
F
N
R
M
--------
F
E
K
S
T
---
H
H
-
Y
T
D
S
-----------
V
G
---------
G
I
L
R
S
T
G
R
Y
L
V
L
Y
-
L
I
I
V
V
G
M
A
Y
L
F
V
R
L
P
S
S
F
L
P
D
E
D
Q
G
V
F
M
T
M
V
Q
L
P
A
G
A
T
Q
E
R
T
Q
K
V
L
---
N
E
V
T
H
Y
Y
L
T
K
--
E
K
N
N
V
E
S
V
F
A
V
---
N
G
--------
F
G
F
A
G
R
G
Q
N
T
G
I
A
F
V
S
L
K
D
----------
W
A
D
R
PGE----
E
---------
N
K
V
E
A
I
T
M
R
A
T
---
R
---
A
F
S
Q
-----
I
K
D
A
--
M
V
F
--
A
F
-----
N
L
-----
P
A
I
VELGT
A
T
G
F
----
D
F
-
E
-
L
I
DQA
G
L
G
------------
H
E
K
L
T
Q
A
R
N
Q
L
-------
L
A
E
A
A
--
K
H
P
M
-
L
T
S
V
R
P
N
G
L
E
D
T
P
Q
F
K
I
D
I
D
Q
E
K
A
Q
A
L
G
V
S
I
N
D
I
N
T
T
L
G
A
A
W
G
G
S
Y
V
N
D
F
I
D
R
G
--
R
V
K
K
V
Y
V
M
S
E
A
K
Y
R
M
L
P
D
D
I
G
D
W
Y
V
R
A
A
D
G
Q
M
V
P
F
S
A
F
S
S
S
R
W
E
Y
G
S
P
R
L
E
R
Y
N
G
L
P
S
--
M
E
I
L
G
Q
A
----
A
P
G
-
K
S
T
G
E
A
M
E
L
M
E
Q
L
A
S
K
L
P
---
T
G
V
G
Y
D
-
W
S
G
N
------------
Q
A
P
S
L
Y
A
I
S
L
I
V
V
F
L
C
L
A
A
L
--
Y
E
S
W
S
I
P
F
S
V
M
L
V
V
P
L
G
V
I
G
A
L
L
A
A
------
T
F
R
G
L
T
N
D
-----------
V
Y
F
Q
-----------
V
G
L
L
T
T
I
G
L
S
----
A
K
N
A
I
L
I
V
E
-
F
A
K
D
L
M
D
K
E
G
K
G
L
I
E
A
T
L
D
A
V
R
M
----
R
L
R
P
I
L
M
T
S
L
A
F
I
L
G
V
M
P
--------------
L
-----
V
ISTGA
G
--
S
---
G
A
Q
N
-----
A
---------
V
G
T
-----
G
V
M
G
G
M
V
T
A
T
V
L
A
I
F
F
V
P
V
F
F
V
V
V
R
R
R
F
S
R
K
-
9
PsiBlast_PDB
80.20
23%
-98
- C2 -
2I6W
-
ACRB_ECOLI
A:
[11-1019]
----------------
F
A
W
V
I
A
I
I
I
M
L
A
G
G
L
A
I
L
K
L
P
V
A
Q
Y
P
T
I
A
P
P
A
V
T
I
S
A
S
Y
P
G
A
D
A
K
T
V
Q
D
T
V
T
Q
V
I
E
Q
N
M
N
G
I
D
N
L
M
Y
M
S
-
S
N
S
------
D
S
T
G
-
T
V
Q
I
T
L
T
F
E
S
G
T
D
A
D
I
A
Q
V
Q
V
Q
--
N
K
L
Q
L
A
M
P
L
L
P
Q
E
V
Q
Q
Q
G
V
S
-----
V
-
E
KSSSS
F
L
-
M
V
V
G
V
I
---
N
-------
T
D
--
G
T-
M
T
Q
E
D
I
S
D
Y
-
V
-
A
A
-
N
M
K
D
A
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S
R
T
S
G
V
G
D
V
Q
L
F
G
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Q
Y
A
M
R
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W
M
N
--
P
N
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L
N
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F
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L
T
P
V
D
V
I
T
A
I
K
A
Q
N
A
Q
V
A
A
G
Q
L
G
----
G
T
P
----
P
VKGQQ
L
N
------
A
S
I
I
A
--
Q
T
R
L
T
--
S
T
E
E
F
-
G
K
I
L
L
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--
V
N
---
Q
--
D
G
S
--
R
V
L
L
R
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L
G
G
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N
Y
D
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---
I
A
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F
N
G
Q
P
A
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-
G
L
G
I
K
L
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A
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A
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L
A
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-
F
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L
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P
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T
T
P
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V
K
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H
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V
K
T
L
V
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A
I
I
L
V
F
L
V
M
Y
L
F
L
Q
N
F
-
R
A
T
L
I
P
T
I
A
V
P
V
V
L
L
G
T
F
A
V
L
A
A
F
G
F
S
I
N
T
L
T
M
F
G
M
V
L
A
I
G
L
L
V
D
D
A
I
V
V
V
E
-
N
V
E
R
V
--
M
-
A
-
E
E
G
L
--
P
P
K
E
A
------------
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
L
S
A
V
F
V
P
M
----
A
F
F
G
G
S
T
G
A
I
Y
-
R
Q
F
S
I
-
T
I
V
S
A
M
A
L
S
V
L
V
A
L
I
L
T
P
A
L
C
A
T
M
L
K
P
-------------------
G
F
F
G
W
F
N
R
M
-
F
E
K
S
-----------
T
H
H
Y
T
D
S
V
G
G
I
L
R
S
T
G
R
Y
L
V
L
Y
L
I
-
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V
V
G
M
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L
F
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R
--
L
P
S
S
F
L
P
D
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V
F
M
T
M
V
Q
L
P
A
G
A
T
Q
E
R
T
Q
K
V
L
---
N
E
V
T
H
Y
Y
L
T
K
--
E
K
N
N
V
E
S
V
F
A
V
---
N
G
-----
F
G
-
F
A
G
R
G
Q
N
T
--
G
I
A
F
V
S
L
K
D
WADRPGEENK
V
E
A
I
-------
T
---------
M
R
A
T
R
A
F
S
Q
I
K
---
D
---
A
M
V
F
-----
A
F
N
L
--
P
A
I
--
V
E
-----
L
G
-----
T
A
T
-----
G
F
D
F
----
E
L
I
D
-
Q
A
---
G
L
G
------------
H
E
K
L
T
Q
A
R
N
Q
L
-------
L
A
E
A
A
--
K
H
P
D
M
L
T
S
V
R
P
N
G
L
E
D
T
P
Q
F
K
I
D
I
D
Q
E
K
A
Q
A
L
G
V
S
I
N
D
I
N
T
T
L
G
A
A
W
G
G
S
Y
V
N
D
F
I
D
R
G
--
R
V
K
K
V
Y
V
M
S
E
A
K
Y
R
M
L
P
D
D
I
G
D
W
Y
V
R
A
A
D
G
Q
M
V
P
F
S
A
F
S
S
S
R
W
E
Y
G
S
P
R
L
E
R
Y
N
G
L
P
S
--
M
E
I
----
L
G
Q
A
A
P
G
-
K
S
T
G
E
A
M
E
L
M
E
Q
L
A
S
K
L
P
---
T
G
V
G
Y
D
W
T
G
M
S
Y
Q
E
R
L
S
-
G
N
Q
A
P
S
L
Y
A
I
S
L
I
V
V
F
L
C
L
A
A
L
-----
Y
E
S
W
S
I
P
F
S
V
M
L
V
V
P
L
G
V
I
G
A
L
L
A
A
------
T
F
R
G
L
T
N
D
-----------
V
Y
F
Q
-----------
V
G
L
L
T
T
I
G
L
S
----
A
K
N
A
I
L
I
V
E
F
A
K
D
L
-
M
D
K
E
G
K
G
L
I
E
A
T
L
D
A
V
R
M
----
R
L
R
P
I
L
M
T
S
L
A
F
I
L
G
V
M
P
--------------
L
-----
V
-----
I
--
S
---
T
G
A
G
-----
S
---------
G
A
Q
N
A
V
G
T
G
V
M
G
G
M
V
T
A
T
V
L
A
I
F
F
V
P
V
F
F
V
V
V
R
-------
6
PsiBlast_PDB
79.87
22%
-107
- C2 -
3KSO
1
CUSA_ECOLI
A:
[33-1043]
--------------------------
I
W
G
T
W
T
I
I
N
T
P
V
D
A
L
P
D
L
S
D
V
Q
V
I
I
K
T
S
Y
P
G
Q
A
P
Q
I
V
E
N
Q
V
T
Y
P
L
T
T
T
M
L
S
V
P
G
A
K
T
V
R
-
G
F
S
-
Q
-
F
-
G
D
S
Y
V
-
Y
V
I
F
E
D
G
T
D
P
-----
Y
-
W
A
R
S
R
V
L
E
Y
L
N
Q
V
Q
G
K
L
P
A
G
V
S
A
E
L
G
P
-----
D
-
A
-----
T
G
---
V
G
W
I
Y
E
Y
A
L
V
D
RSGK
H
D
--
L
--
A
D
L
R
S
L
Q
D
W
-
F
----
L
K
Y
E
-
L
K
T
I
P
D
V
A
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V
A
S
V
G
G
V
V
K
E
-
Y
Q
V
V
I
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P
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R
L
A
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Y
G
I
S
L
A
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V
K
S
A
L
D
A
S
N
Q
E
A
G
G
S
S
I
E
----
L
A
E
----
A
------
E
------
Y
M
V
R
A
--
S
G
Y
L
Q
--
T
L
D
D
F
-
N
H
I
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L
K
--
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---
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--
N
G
V
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Y
--
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A
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---
I
G
P
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RR
G
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A
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L
N
G
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G
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A
G
G
V
V
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L
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G
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A
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V
A
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-
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A
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A
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L
P
L
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L
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M
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G
L
N
A
N
I
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L
G
G
I
A
I
A
V
G
A
M
V
D
A
A
I
V
M
I
E
N
A
H
K
R
L
--
E
-
E
-
W
Q
H
Q
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T
R
W
Q
V
I
T
D
A
S
V
E
V
G
P
A
L
F
I
S
L
L
I
I
T
L
S
-----
F
I
P
I
F
TLE
G
Q
E
G
R
L
F
G
P
L
A
-
F
T
K
T
Y
-
A
M
A
G
A
A
L
L
----
A
I
V
V
I
P
I
L
M
G
-------------
N
P
--------
L
N
R
F
L
---
I
R
V
Y
H
P
L
-----------
L
L
---------
K
V
L
H
W
P
K
T
T
L
L
V
A
-
A
L
S
V
L
T
V
L
W
P
L
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K
V
G
G
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L
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N
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D
L
L
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M
P
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T
L
P
G
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A
A
E
A
A
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M
L
---
Q
K
T
D
K
L
I
M
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--
P
E
V
A
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V
F
G
K
T
G
---
K
A
----------
E
T
A
T
D
S
A
P
L
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M
V
E
T
T
I
Q
----------
L
K
P
Q
-------
E
QWRPGMT
M
D
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I
I
E
E
L
D
N
T
V
R
---
L
---
P
G
L
A
------
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L
W
--
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P
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--
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N
R
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-----
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-----
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----
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-
K
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V
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---
G
T
V
------------
L
A
D
I
D
A
M
A
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I
-------
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E
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--
T
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-
V
A
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A
L
A
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A
A
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Y
G
M
T
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A
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G
A
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P
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--
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Q
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W
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A
L
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L
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L
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M
K
Q
Q
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D
V
A
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K
V
S
T
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P
S
M
L
K
T
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N
A
R
P
T
S
W
I
Y
I
D
A
R
D
R
D
M
V
S
V
V
H
D
L
Q
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A
I
A
E
K
V
Q
-----
L
K
---
P
G
T
S
V
A
-
F
S
G
Q
F
E
L
--
L
-
E
R
A
N
H
K
L
K
L
M
V
P
M
T
L
M
I
I
F
V
L
L
Y
L
A
--
F
R
R
V
G
E
A
L
L
I
I
S
S
V
P
F
A
L
V
G
G
I
W
L
L
W
W
M
G
F
H
L
S
V
A
T
G
T
G
-----------
F
I
A
L
-----------
A
G
V
A
A
E
F
G
V
V
M
L
M
Y
L
R
H
A
I
E
A
V
P
-
S
L
N
N
-
P
Q
T
F
S
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---
Q
K
L
D
E
A
L
Y
H
G
A
V
L
R
V
R
P
K
A
M
T
V
A
V
I
I
A
G
L
L
P
--------------
I
-------------------
L
W
G
-----
T
GAGS
E
V
M
S
R
I
A
A
-----
P
M
I
G
G
M
I
T
A
P
L
L
S
L
F
I
I
P
A
A
Y
K
L
M
--------
11
PsiBlast_PDB
79.74
23%
-98
- C2 -
2W1B
1
ACRB_ECOLI
A:
[11-1019]
----------------
F
A
W
V
I
A
I
I
I
M
L
A
G
G
L
A
I
L
K
L
P
V
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Q
Y
P
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A
P
P
A
V
T
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A
S
Y
P
G
A
D
A
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D
T
V
T
Q
V
I
E
Q
N
M
N
G
I
D
N
L
M
Y
M
S
-
S
N
S
------
D
S
T
G
-
T
V
Q
I
T
L
T
F
E
S
G
T
D
A
D
I
A
Q
V
Q
V
Q
--
N
K
L
Q
L
A
M
P
L
L
P
Q
E
V
Q
Q
Q
G
V
S
-----
V
-
E
KSSSS
F
L
-
M
V
V
G
V
I
---
N
-------
T
D
--
G
T-
M
T
Q
E
D
I
S
D
Y
-
V
-
A
A
-
N
M
K
D
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S
R
T
S
G
V
G
D
V
Q
L
F
G
S
Q
Y
A
M
R
I
W
M
N
--
P
N
E
L
N
K
F
Q
L
T
P
V
D
V
I
T
A
I
K
A
Q
N
A
Q
V
A
A
G
Q
L
G
----
G
T
P
----
P
VKGQQ
L
N
------
A
S
I
I
A
--
Q
T
R
L
T
--
S
T
E
E
F
-
G
K
I
L
L
K
--
V
N
---
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--
D
G
S
--
R
V
L
L
R
D
V
A
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L
G
G
E
N
Y
D
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---
I
A
E
F
N
G
Q
P
A
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-
G
L
G
I
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L
A
T
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A
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A
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A
A
A
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M
V
L
A
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L
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D
D
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V
V
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-
N
V
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--
M
-
A
-
E
E
G
L
--
P
P
K
E
A
------------
T
R
K
S
M
G
Q
I
Q
G
A
L
V
G
I
A
M
V
LS
A
V
F
V
P
M
----
A
F
F
G
G
S
T
G
A
I
Y
-
R
Q
F
S
I
-
T
I
V
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A
M
A
L
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L
V
A
L
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T
P
A
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C
A
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A
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G
D
H
G
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G
K
--------
K
G
F
F
G
W
F
N
R
M
-
F
E
K
S
-----------
T
H
H
Y
T
D
S
V
G
G
I
L
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T
G
R
Y
L
V
L
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L
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-
I
V
V
G
M
A
Y
L
F
V
R
--
L
P
S
S
F
L
P
D
E
D
Q
G
V
F
M
T
M
V
Q
L
P
A
G
A
T
Q
E
R
T
Q
K
V
L
---
N
E
V
T
H
Y
Y
L
T
K
--
E
K
N
N
V
E
S
V
F
A
V
---
N
G
-----
F
G
-
F
A
G
R
G
Q
N
T
--
G
I
A
F
V
S
L
K
D
WADRPGEENK
V
E
A
I
-------
T
---------
M
R
A
T
R
A
F
S
Q
I
K
---
D
---
A
M
V
F
-----
A
F
N
L
--
P
A
I
--
V
E
-----
L
G
-----
T
A
T
-----
G
F
D
F
----
E
L
I
D
-
Q
A
---
G
L
G
------------
H
E
K
L
T
Q
A
R
N
Q
L
-------
L
A
E
A
A
--
K
H
P
D
M
L
T
S
V
R
P
N
G
L
E
D
T
P
Q
F
K
I
D
I
D
Q
E
K
A
Q
A
L
G
V
S
I
N
D
I
N
T
T
L
G
A
A
W
G
G
S
Y
V
N
D
F
I
D
R
G
--
R
V
K
K
V
Y
V
M
S
E
A
K
Y
R
M
L
P
D
D
I
G
D
W
Y
V
R
A
A
D
G
Q
M
V
P
F
S
A
F
S
S
S
R
W
E
Y
G
S
P
R
L
E
R
Y
N
G
L
P
S
--
M
E
I
----
L
G
Q
A
A
P
G
-
K
S
T
G
E
A
M
E
L
M
E
Q
L
A
S
K
L
P
---
T
G
V
G
Y
D
W
T
G
M
S
Y
Q
E
R
L
S
-
G
N
Q
A
P
S
L
Y
A
I
S
L
I
V
V
F
L
C
L
A
A
L
-----
Y
E
S
W
S
I
P
F
S
V
M
L
V
V
P
L
G
V
I
G
A
L
L
A
A
------
T
F
R
G
L
T
N
D
-----------
V
Y
F
Q
-----------
V
G
L
L
T
T
I
G
L
S
----
A
K
N
A
I
L
I
V
E
F
A
K
D
L
-
M
D
K
E
G
K
G
L
I
E
A
T
L
D
A
V
R
M
----
R
L
R
P
I
L
M
T
S
L
A
F
I
L
G
V
M
P
--------------
L
-----
V
-----
I
--
S
---
T
G
A
G
-----
S
---------
G
A
Q
N
A
V
G
T
G
V
M
G
G
M
V
T
A
T
V
L
A
I
F
F
V
P
V
F
F
V
V
V
R
R
R
F
----
5
PsiBlast_PDB
79.71
23%
-99
- C2 -
4MT1
-
?
A:
[11-1034]
----------------
F
A
W
V
I
S
I
F
I
I
A
A
G
I
F
G
I
K
S
L
P
V
S
Q
Y
P
S
V
A
A
P
T
I
T
L
H
A
I
Y
P
G
A
S
A
Q
V
M
E
G
S
V
L
S
V
I
E
R
N
M
N
G
V
E
G
L
D
Y
M
S
T
S
A
D
-
S
-
S
-
G
S
G
S
V
S
L
T
F
T
P
D
T
D
E
--
N
L
A
Q
V
---
E
V
Q
--
N
K
L
S
E
V
L
S
T
L
P
A
T
V
Q
Q
Y
G
V
T
V
----
S
-
K
-----
A
R
-
S
N
F
L
M
I
V
M
L
S
-------
S
D
--
V
--
Q
S
T
E
E
M
N
D
Y
-
A
-
Q
R
N
V
V
P
E
-
L
Q
R
I
E
G
V
G
Q
V
R
L
F
G
A
Q
R
A
M
R
I
W
V
D
--
P
K
K
L
Q
N
Y
N
L
S
F
A
D
V
G
S
A
L
S
A
Q
N
I
Q
I
S
A
G
S
I
G
----
S
L
P
----
A
VRGQ
T
V
T
------
A
T
V
T
A
--
Q
G
Q
L
G
--
T
A
E
E
F
-
G
N
V
I
L
R
--
A
N
TDG
S
--
N
I
Y
-----
L
K
D
V
A
K
V
G
L
G
M
E
D
Y
S
S
--
S
T
-
R
L
N
G
V
N
T
T
-
G
M
A
V
M
L
S
N
S
G
N
A
M
A
T
A
K
A
V
K
E
R
L
A
V
L
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K
Y
-
F
P
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G
M
S
W
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H
T
L
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A
M
V
L
V
F
V
V
M
Y
L
F
L
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N
I
-
R
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T
L
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P
T
I
V
V
P
I
S
L
L
G
G
F
A
F
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S
Y
M
G
M
S
I
N
V
L
T
M
F
A
M
I
L
V
I
G
I
V
V
D
D
A
I
V
V
V
E
-
N
V
E
R
I
--
M
-
A
-
G
E
G
L
P
P
K
E
A
T
K
K
---------
A
M
G
Q
I
S
G
A
V
I
G
I
T
A
V
L
I
S
V
-----
F
V
P
L
----
A
M
F
S
G
A
A
G
N
I
Y
-
K
Q
F
A
L
-
T
M
A
S
S
I
A
F
S
A
F
L
A
L
T
L
T
P
A
L
C
A
T
-----------------------
G
F
F
G
W
F
N
K
K
-
F
D
S
W
-----------
T
H
G
Y
E
G
R
V
A
--
K
V
L
R
K
T
F
R
M
M
V
V
Y
-
I
G
L
A
V
V
G
V
F
L
F
M
R
L
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T
S
F
L
P
T
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D
Q
G
F
V
M
V
S
V
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L
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A
G
A
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K
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T
D
A
T
L
A
Q
V
T
Q
L
A
K
S
I
P
E
I
--
E
N
I
I
T
V
S
G
F
S
F
---
S
G
S
--------
G
Q
N
M
A
M
G
F
-----
A
I
F
K
D
----------
W
N
E
R
-------
T
ASGSD
A
V
--
A
V
A
G
K
L
T
G
M
M
M
G
TL
K
---
D
G
F
G
-----
I
A
V
V
--
P
P
P
I-
L
E
-----
L
G
-------
S
-----
G
L
S
I
----
N
L
-
Q
-
D
R
---
N
N
T
G
H
T
A
L
L
A
K
R
N
E
L
I
Q
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M
R
--
A
S
G
L
FDPST
V
R
A
G
G
L
E
--
D
S
P
Q
---------------
L
K
I
D
I
N
R
A
A
A
A
A
Q
G
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S
F
A
D
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V
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--
R
L
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R
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V
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D
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A
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A
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L
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V
A
V
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L
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I
A
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S
W
E
N
G
T
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Q
S
V
R
F
N
G
Y
P
S
--
M
K
L
S
A
S
P
A
T
G
V
S
-----
T
G
Q
A
M
E
A
V
Q
K
M
V
D
E
L
G
---
G
G
Y
S
F
E
-
W
G
G
--
Q
S
--
S
-
E
E
A
K
G
G
S
Q
T
L
I
L
Y
G
L
A
V
A
A
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F
L
V
L
A
A
L
Y
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W
S
I
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L
A
V
I
L
V
I
P
L
G
L
I
G
A
A
A
G
V
------
T
G
R
N
L
F
E
G
-----------
L
L
G
S
VPSFAND
I
Y
F
Q
V
G
F
V
T
V
M
G
L
S
----
A
K
N
A
I
L
I
I
E
-
F
A
K
D
-
L
Q
A
Q
G
K
S
A
V
E
A
A
L
E
A
A
R
L
----
R
F
R
P
I
I
M
T
S
F
A
F
I
L
G
V
V
P
LYIAAGAS
S
A
S
Q
R
A
I
-----
G
-----
T
--
T
---
V
F
W
----------------------------
G
M
L
V
G
T
L
L
S
V
F
L
V
P
L
F
Y
V
V
V
R
K
F
F
----