@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0159: (2015-12-24 )
MDTLQGMRVFARVVDSGSFTSAAQALDLSTAQVSRLISDLEAHLQTRLLHRTTRRLALTEAGERYLERCRGILEDIEVAEAEAAGAHIRPCGRLRVQSLMGMGQHHLVPMIARYGALFPDVVIELTLSQRNPDMLEEGQDVLITGERQLPDSEFVAQRLGSIHSVLCASPGYLQQHGVPRSVDDLERHVCLRLQDPAYPEGWIFADEQGERTVSPQNTFMVNVAEVMAQAAKADLGIALLPSYVAAAALRNGELLRVLPGHAMHQRTIYALYPSRRYLDAKIRTWVDLLQQELPQAFARDETTMQSSSYCAQ
Atome Classification :
(20 SA)
----.........10........20........30........40........50........60........70...-.....80......-..90.-.......-100........110.......120.....--.--.--130--...-....-140..-......--150-.........-160.......170..-..---...180......---.-190.....-..-200..-.-......-210.-.-...---...220-...-....230.......240.......250....-...260.-.-......-270.......280.......290.......300.......310
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----MD
T
L
Q
G
M
R
V
F
A
R
V
VDSGSFT
S
A
A
Q
ALD
L
S
T
A
Q
V
S
R
L
I
S
D
L
E
A
H
L
Q
T
R
L
L
H
R
T
T
R
R
L
A
L
T
E
A
G
E
R
Y
L
E
R
C
R
G
I
L
E
-
D
I
E
V
AEAEAAGAH-IRP
C
G
-
R
L
R
V
Q
S
L
-M-GM
G
Q
H
H
L
V
P
M
I
A
R
Y
GAL
F
P
D
V
V
I
E
L
T
L--S--Q--RN
P
--
D
M
L
-EEG
Q
-
D
V
-
L
I
-TGERQL--P---
D
S
E
F
V
A
Q
R
L
-
G
S
I
H
S
V
L
CASP
G
Y
L
Q
-QH---GVPR
S
V
D
D
L
E
R
H
---
V
-
C
L
R
LQDPA-YP-E--G
W
-
I
-
F
ADEQG-E-RT-V-SPQ---N
T
F
M
V
N
-
V
A
E
-
V
M
A
Q
A
A
KADL
G
I
A
L
L
P
S
Y
V
A
A
A
A
LRNG
E
L
L
R
-VLPGH-A-M-
H
Q
R
T
I
Y
-
A
LYPSR
R
Y
L
D
A
K
I
R
T
W
V
D
L
L
Q
Q
E
L
P
Q
A
F
ARDETTMQSSSYCAQ
3
PsiBlast_PDB
90.72
31%
-133
- C2 -
3SZP
-
?
A:
[3-285]
-------
L
D
D
L
N
L
F
R
L
V
V
E
N
G
S
Y
T
S
T
S
K
K
T
M
I
P
V
A
T
I
T
R
R
I
Q
A
L
E
D
S
L
N
L
R
L
L
N
R
H
A
R
K
L
T
L
T
E
A
G
E
R
F
Y
K
D
C
S
P
L
L
E
-
R
L
A
S
M
T
E
E
I
T
D
E
C
-
R
G
A
S
G
-
R
I
R
I
S
A
P
-
S
-
N
L
T
K
R
M
M
M
P
M
F
N
A
F
M
E
K
Y
P
D
I
H
I
E
L
M
M
--
S
--
N
--
Q
A
D
--
D
L
D
-
P
T
E
W
-
D
V
-
I
F
R
V
G
P
Q
R
-------
D
S
S
L
I
A
R
K
I
-
G
E
V
K
D
I
L
V
A
S
P
Q
Y
L
S
-
S
H
---
P
Q
P
T
H
A
E
E
L
H
Q
H
---
Q
-
L
L
K
----
G
-
Y
P
L
L
--
K
W
-
Q
-
L
T
N
S
Q
G
-
E
-
T
V
-
V
N
S
D
R
---
G
R
F
Q
A
S
-
A
L
N
-
V
V
R
S
A
C
S
E
G
L
G
I
T
L
M
P
D
V
M
L
R
E
F
L
E
D
G
S
L
V
Q
-
V
L
S
D
W
-
S
-
S
-
N
P
R
D
I
Y
-
M
L
Y
N
H
K
D
H
Q
P
E
K
V
R
L
F
I
D
F
V
I
G
Y
H
L
------------------
22
HHSearch
90.21
30%
-130
- C2 -
3SZP
-
?
A:
[1-290]
-----
M
K
L
D
D
L
N
L
F
R
L
V
V
E
N
G
S
Y
T
S
T
S
K
K
T
M
I
P
V
A
T
I
T
R
R
I
Q
A
L
E
D
S
L
N
L
R
L
L
N
R
H
A
R
K
L
T
L
T
E
A
G
E
R
F
Y
K
D
C
S
P
L
L
E
-
R
L
A
S
M
T
E
E
I
T
D
E
C
-
R
G
A
S
G
-
R
I
R
I
S
A
P
-
S
-
N
L
T
K
R
M
M
M
P
M
F
N
A
F
M
E
K
Y
P
D
I
H
I
E
L
M
M
--
S
--
N
--
Q
A
---
D
D
L
D
P
T
E
W
-
D
V
-
I
F
-
R
V
G
P
-
Q
--
R
---
D
S
S
L
I
A
R
K
I
-
G
E
V
K
D
I
L
V
A
S
P
Q
Y
L
S
-
S
H
---
P
Q
P
T
H
A
E
E
L
H
Q
H
---
Q
-
L
L
K
G
Y
P
L
L
-------
K
W
-
Q
-
L
T
N
S
Q
G
-
E
-
T
V
V
N
-
S
D
R
---
G
R
F
Q
A
S
-
A
L
N
-
V
V
R
S
A
C
S
E
G
L
G
I
T
L
M
P
D
V
M
L
R
E
F
L
E
D
G
S
L
V
Q
-
V
L
S
D
W
-
S
-
S
-
N
P
R
D
I
Y
-
M
L
Y
N
H
K
D
H
Q
P
E
K
V
R
L
F
I
D
F
V
I
G
Y
H
L
------------------
21
HHSearch
89.37
31%
-112
- C2 -
3HHG
-
?
A:
[2-294]
----
K
T
N
S
E
E
L
T
V
F
V
Q
V
V
E
S
G
S
F
S
R
A
A
E
Q
L
A
M
A
N
S
A
V
S
R
I
V
K
R
L
E
E
K
L
G
V
N
L
L
N
R
T
T
R
Q
L
S
L
T
E
E
G
A
Q
Y
F
R
R
A
Q
R
I
L
Q
-
E
M
A
A
A
E
T
E
M
L
A
V
H
-
E
I
P
Q
G
-
V
L
S
V
D
S
A
-
M
-
P
M
V
L
H
L
L
A
P
L
A
A
K
F
N
E
R
Y
P
H
I
R
L
S
L
V
S
--
S
--
E
--
G
Y
I
--
N
L
I
-
E
R
K
V
-
D
I
-
A
L
-
R
A
G
E
-
L
--
D
---
D
S
G
L
R
A
R
H
L
-
F
D
S
R
F
R
V
I
A
S
P
E
Y
L
A
-
K
H
---
G
T
P
Q
S
T
E
E
L
A
G
H
---
Q
-
C
L
G
F
T
E
P
G
-
S
L
-
N
--
T
W
-
A
-
V
L
D
A
Q
G
-
N
-
P
Y
---
K
I
S
---
P
H
F
T
A
S
-
S
G
E
-
I
L
R
S
L
C
L
S
G
C
G
I
V
C
L
S
D
F
L
V
D
N
D
I
A
E
G
K
L
I
P
-
L
L
A
E
Q
T
S
-
D
-
K
T
H
P
F
N
-
A
V
Y
Y
S
D
K
A
V
N
L
R
L
R
V
F
L
D
F
L
V
E
E
L
G
------------------
2
PsiBlast_PDB
88.72
33%
-126
- C2 -
3HHG
-
?
A:
[8-293]
----------
L
T
V
F
V
Q
V
V
E
S
G
S
F
S
R
A
A
E
Q
L
A
M
A
N
S
A
V
S
R
I
V
K
R
L
E
E
K
L
G
V
N
L
L
N
R
T
T
R
Q
L
S
L
T
E
E
G
A
Q
Y
F
R
R
A
Q
R
I
L
Q
-
E
M
A
A
A
E
T
E
M
L
A
V
H
-
E
I
P
Q
G
-
V
L
S
V
D
S
A
-
M
-
P
M
V
L
H
L
L
A
P
L
A
A
K
F
N
E
R
Y
P
H
I
R
L
S
L
V
S
--
S
--
E
--
G
Y
I
--
N
L
I
-
E
R
K
V
-
D
I
A
L
R
-
A
G
E
--
L
--
D
---
D
S
G
L
R
A
R
H
L
-
F
D
S
R
F
R
V
I
A
S
P
E
Y
L
A
-
K
H
---
G
T
P
Q
S
T
E
E
L
A
G
H
---
Q
-
C
L
G
F
T
E
P
G
-
S
L
-
N
--
T
W
-
A
-
V
L
D
A
Q
G
-
N
P
Y
K
-
I
-
S
P
H
-----
F
T
A
S
-
S
G
E
-
I
L
R
S
L
C
L
S
G
C
G
I
V
C
L
S
D
F
L
V
D
N
D
I
A
E
G
K
L
I
P
-
L
L
A
E
Q
-
T
-
S
-
D
K
T
H
P
F
N
A
V
Y
Y
S
D
K
A
V
N
L
R
L
R
V
F
L
D
F
L
V
E
E
L
G
------------------
4
PsiBlast_PDB
88.61
31%
-120
- C2 -
3T1B
-
?
B:
[3-285]
-------
L
D
D
L
N
L
F
R
L
V
V
E
N
G
S
Y
T
S
T
S
K
K
T
M
I
P
V
A
T
I
T
R
R
I
Q
A
L
E
D
S
L
N
L
R
L
L
N
R
H
A
R
K
L
T
L
T
E
A
G
E
R
F
Y
K
D
C
S
P
L
L
E
-
R
L
A
S
M
T
E
E
I
T
D
E
C
-
R
G
A
S
G
-
R
I
R
I
S
A
P
-
S
-
E
L
T
K
R
M
M
M
P
M
F
N
A
F
M
E
K
Y
P
D
I
H
I
E
L
M
M
--
S
--
N
--
Q
A
D
---
L
D
-
P
T
E
W
-
D
V
-
I
F
R
V
G
P
Q
R
-------
D
S
S
L
I
A
R
K
I
-
G
E
V
K
D
I
L
V
A
S
P
Q
Y
L
S
-
S
H
---
P
Q
P
T
H
A
E
E
L
H
Q
H
---
Q
-
L
L
K
----
G
-
Y
P
L
L
--
K
W
-
Q
-
L
T
N
S
Q
G
-
E
-
T
V
-
V
N
S
D
R
---
G
R
F
Q
A
S
-
A
L
N
-
V
V
R
S
A
C
S
E
G
L
G
I
T
L
M
P
D
V
M
L
R
E
F
L
E
D
G
S
L
V
Q
-
V
L
S
D
W
-
S
-
S
-
N
P
R
D
I
Y
-
M
L
Y
N
H
K
D
H
Q
P
E
K
V
R
L
F
I
D
F
V
I
G
Y
H
L
------------------
27
HHSearch
75.35
33%
-118
- C2 -
3MZ1
-
?
A:
[85-296]
----------------------------------------------------------------------------------------------
L
P
K
G
-
R
L
R
V
E
T
A
-
S
-
A
F
A
N
L
V
I
I
P
A
L
P
E
F
H
K
K
Y
P
D
I
Q
I
D
L
G
V
--
S
--
D
--
R
T
----
Y
L
-
A
E
N
V
-
D
C
-
A
I
-
R
A
G
T
-
L
--
T
---
D
Q
S
L
I
A
R
R
I
-
T
E
M
K
F
V
A
C
A
S
R
D
F
L
E
-
R
H
---
P
V
P
Q
H
P
S
D
L
E
K
N
---
C
-
Y
V
V
G
Y
F
L
P
K---
Q
Q
M
P
F
-
H
-
F
R
R
G
N
--
E
-
E
I
-
E
V
S
G
R
---
Y
T
M
A
A
N
-
E
S
T
-
T
Y
L
A
A
A
R
A
G
L
G
V
I
Q
A
P
L
F
M
V
R
E
D
L
R
N
G
T
M
V
P
-
V
L
P
D
W
-
Q
-
V
-
E
P
M
P
I
Y
-
L
V
Y
P
P
N
R
H
L
S
S
R
L
R
V
F
A
D
W
V
V
K
V
M
A
Q
S
Q
N
--------------
1
PsiBlast_PDB
73.61
34%
-122
- C2 -
3MZ1
-
?
A:
[85-287]
----------------------------------------------------------------------------------------------
L
P
K
G
-
R
L
R
V
E
T
A
-
S
-
A
F
A
N
L
V
I
I
P
A
L
P
E
F
H
K
K
Y
P
D
I
Q
I
D
L
G
V
--
S
--
D
--
R
T
----
Y
L
-
A
E
N
V
-
D
C
-
A
I
-
R
A
G
-
T
L
--
T
---
D
Q
S
L
I
A
R
R
I
-
T
E
M
K
F
V
A
C
A
S
R
D
F
L
E
-
R
H
---
P
V
P
Q
H
P
S
D
L
E
K
N
CYV
V
-
G
Y
F
L
P
K
---
Q
Q
-
M
--
P
F
-
H
-
F
R
R
G
N
E
-
E
-
I
E
-
V
-
S
G
R
---
Y
T
M
A
A
N
-
E
S
T
-
T
Y
L
A
A
A
R
A
G
L
G
V
I
Q
A
P
L
F
M
V
R
E
D
L
R
N
G
T
M
V
P
-
V
L
P
D
W
-
Q
-
V
-
E
P
M
P
I
Y
-
L
V
Y
P
P
N
R
H
L
S
S
R
L
R
V
F
A
D
W
V
V
K
V
M
A
Q
S
Q
N
--------------
43
Fugue
70.98
26%
-129
* C2 *
3HHF
1
?
A:
[5-207]
-----------------------------------------------------------------------------------------------
P
Q
G
-
V
L
S
V
D
S
A
M
P
M
V
L
H
--
L
L
A
P
L
A
A
K
F
N
E
R
Y
P
H
I
R
L
S
L
V
S
--
S
--
E
--
G
Y
I
--
N
L
I
-
E
R
K
V
-
D
I
-
A
L
-
R
A
G
-
E
L
--
D
---
D
S
G
L
R
A
R
H
L
-
F
D
S
R
F
R
V
I
A
S
P
E
Y
L
A
-
K
H
---
G
T
P
Q
S
T
E
E
L
A
G
H
---
Q
-
C
L
G
F
T
E
P
G
-
S
L
-
N
--
T
W
-
A
-
V
L
D
A
Q
G
-
N
--
P
-
Y
-
K
I
S
---
P
H
F
T
A
S
-
S
G
E
-
I
L
R
S
L
C
L
S
G
C
G
I
V
C
L
S
D
F
L
V
D
N
D
I
A
E
G
K
L
I
P
-
L
L
A
E
Q
-
T
-
S
D
K
T
H
P
F
N
-
A
V
Y
Y
S
D
K
A
V
N
L
R
L
R
V
F
L
D
F
L
V
E
E
L
G
------------------
5
PsiBlast_PDB
70.81
28%
-128
- C2 -
3HHF
1
?
B:
[5-207]
-----------------------------------------------------------------------------------------------
P
Q
G
-
V
L
S
V
D
S
A
-
M
-
P
M
V
L
H
L
L
A
P
L
A
A
K
F
N
E
R
Y
P
H
I
R
L
S
L
V
S
--
S
--
E
--
G
Y
I
--
N
L
I
-
E
R
K
V
-
D
I
A
L
R
-
A
G
------
D
---
D
S
G
L
R
A
R
H
L
-
F
D
S
R
F
R
V
I
A
S
P
E
Y
L
A
-
K
H
---
G
T
P
Q
S
T
E
E
L
A
G
H
---
Q
-
C
L
G
F
T
E
P
G
-
S
L
-
N
--
T
W
-
A
-
V
L
D
A
Q
G
-
N
P
Y
K
-
I
-
S
P
H
-----
F
T
A
S
-
S
G
E
-
I
L
R
S
L
C
L
S
G
C
G
I
V
C
L
S
D
F
L
V
D
N
D
I
A
E
G
K
L
I
P
-
L
L
A
E
Q
-
T
-
S
-
D
K
T
H
P
F
N
A
V
Y
Y
S
D
K
A
V
N
L
R
L
R
V
F
L
D
F
L
V
E
E
L
G
------------------
38
HHSearch
70.34
27%
-117
- C2 -
3HHF
1
?
B:
[5-208]
-----------------------------------------------------------------------------------------------
P
Q
G
-
V
L
S
V
D
S
A
-
M
-
P
M
V
L
H
L
L
A
P
L
A
A
K
F
N
E
R
Y
P
H
I
R
L
S
L
V
S
--
S
--
E
--
G
Y
I
--
N
L
I
-
E
R
K
V
-
D
I
-
A
L
-
R
A
G
-----
D
---
D
S
G
L
R
A
R
H
L
-
F
D
S
R
F
R
V
I
A
S
P
E
Y
L
A
-
K
H
---
G
T
P
Q
S
T
E
E
L
A
G
H
---
Q
-
C
L
G
F
T
E
P
G
-
S
L
-
N
--
T
W
-
A
-
V
L
D
A
Q
G
-
N
-
P
Y
---
K
I
S
---
P
H
F
T
A
S
-
S
G
E
-
I
L
R
S
L
C
L
S
G
C
G
I
V
C
L
S
D
F
L
V
D
N
D
I
A
E
G
K
L
I
P
-
L
L
A
E
Q
-
T
S
D
-
K
T
H
P
F
N
-
A
V
Y
Y
S
D
K
A
V
N
L
R
L
R
V
F
L
D
F
L
V
E
E
L
G
------------------
23
HHSearch
68.19
20%
-108
- C2 -
3FXQ
7
TSAR_COMTE
A:
[1-296]
----
M
L
K
L
Q
T
L
Q
A
L
I
C
I
E
E
V
G
S
L
R
A
A
A
Q
L
L
H
L
S
Q
P
A
L
S
A
A
I
Q
Q
L
E
D
E
L
K
A
P
L
L
V
R
T
K
R
G
V
S
L
T
S
F
G
Q
A
F
M
K
H
A
R
L
I
V
T
-
E
S
R
R
A
Q
E
E
I
G
Q
L
R
-
G
R
W
E
G
-
H
I
T
F
A
A
S
-
P
-
A
I
A
L
A
A
L
P
L
A
L
A
S
F
A
R
E
F
P
D
V
T
V
N
V
R
D
--
G
--
M
Y
P
A
V
S
--
P
Q
L
R
D
G
T
L
-
D
F
-
A
L
-
T
A
A
H
K
H
D-
I
---
D
T
D
L
E
A
Q
P
L
-
Y
V
S
D
V
V
I
V
G
Q
R
Q
H
P
M
-
A
N
-----
A
T
R
L
A
E
L
Q
E
C
---
R
-
W
A
F
S
S
A
P
R
-
G
P
-
G
A
-
I
I
R
N
A
F
A
R
Y
G
-----
L
-
P
-
E
P
K
---
L
G
L
V
C
E
-
S
F
L
-
A
L
P
G
V
V
A
H
S
D
L
L
T
T
M
P
R
T
L
Y
E
R
N
A
F
K
D
Q
L
C
S
-
I
P
L
Q
D
-
A
-
L
-
P
N
P
T
I
Y
-
V
L
R
R
H
D
L
P
V
T
P
A
A
A
G
L
I
R
W
I
Q
H
H
A
L
------------------
45
Fugue
66.70
20%
-91
- C2 -
3ISP
-
Y1985_MYCTU
A:
[5-296]
----
Q
L
D
G
P
Q
L
A
A
L
A
A
V
V
E
L
G
S
F
D
A
A
A
E
R
L
H
V
T
P
S
A
V
S
Q
R
I
K
S
L
E
Q
Q
V
G
Q
V
L
V
V
R
E
-
K
P
C
R
A
T
T
A
G
I
P
L
L
R
L
A
A
Q
T
A
L
-
L
E
S
E
A
L
A
E
M
G
A
-------
S
-
L
K
R
T
R
I
T
-
I
-
A
V
N
A
D
S
M
A
T
W
F
S
A
V
F
D
G
L
G
D
V
L
L
D
V
R
I
ED
Q
--
D
--
H
S
A
--
R
L
L
-
R
E
G
V
-
A
M
-
G
A
-
V
T
T
E
R
N
--
P
---
V
P
G
C
R
V
H
P
L
-
G
E
M
R
Y
L
P
V
A
S
R
P
F
V
Q
-
R
H
LSD
G
F
T
A
--
A
A
A
A
K
A
---
P
-
S
L
A
W
N
R
D
D
-
G
L
-
Q
--
D
M
-
L
-
V
R
K
A
F
R
-
R
-
A
I
-
T
-
R
P
T
---
H
F
--
V
P
-
T
T
E
-
G
F
T
A
A
A
R
A
G
L
G
W
G
M
F
P
E
K
L
A
A
S
P
L
A
D
G
S
F
V
R
-
V
C
D
I
H
-----
L
D
V
P
L
Y
-
W
Q
C
W
K
L
D
S
--
P
I
I
A
R
I
T
D
T
V
R
A
A
A
S
G
L
Y
R
G
Q
------------
32
HHSearch
64.92
20%
-85
- C2 -
3ISP
-
Y1985_MYCTU
A:
[5-296]
----
Q
L
D
G
P
Q
L
A
A
L
A
A
V
V
E
L
G
S
F
D
A
A
A
E
R
L
H
V
T
P
S
A
V
S
Q
R
I
K
S
L
E
Q
Q
V
G
Q
V
L
V
V
R
E
-
K
P
C
R
A
T
T
A
G
I
P
L
L
R
L
A
A
Q
T
A
L
-
L
E
S
E
A
L
A
E
M
G
--
A
-
S
L
K
R
T
-
R
I
T
I
A
V
N
-
A
-
D
S
M
A
T
W
F
S
A
V
F
D
G
----
L
G
D
V
L
L
D
V
R
I
--
E
D
Q
D
--
H
S
A
--
R
L
L
R
E
G
V
A
-
M
G
-
A
V
-
T
T
E
R
-
N
--
P
---
V
P
G
C
R
V
H
P
L
-
G
E
M
R
Y
L
P
V
A
S
R
P
F
V
Q
-
R
H
L--
S
D
G
F
T
A
A
A
A
A
K
A
---
P
-
S
L
A
W
N
R
D
D
-
G
L
-
Q
--
D
M
-
L
-
V
R
K
A
F
--
R
-
R
A
---
I
T
R
---
P
T
H
F
V
P
-
T
T
E
-
G
F
T
A
A
A
R
A
G
L
G
W
G
M
F
P
E
K
L
A
A
S
P
L
A
D
G
S
F
V
R
-
V
C
D
-
I
------
H
L
D
V
P
-
L
Y
W
Q
C
W
K
L
D
S
P
I
I
A
R
I
T
D
T
V
R
A
A
A
S
G
L
Y
R
G
Q
------------
46
Fugue
64.08
20%
-101
- C2 -
3FZV
1
?
A:
[4-300]
-----
Y
T
L
R
Q
L
K
Y
F
V
T
T
V
E
C
G
S
V
A
E
A
S
R
K
L
Y
I
A
Q
-
S
I
S
T
A
V
K
G
L
E
E
S
F
V
Q
---------
L
F
L
T
P
A
G
A
R
F
Y
R
K
A
Q
E
L
L
R
M
A
H
E
F
E
Q
N
L
A
D
N
D
V
-
I
A
--
G
-
Q
I
D
I
G
C
F
-
E
-
T
V
A
P
L
Y
L
P
G
L
I
A
G
F
R
Q
A
Y
P
G
V
E
I
R
I
R
D
G
E
Q
--
Q
--
E
L
V
--
Q
G
L
-
T
S
G
R
F
D
L
-
A
F
-
L
Y
E
H
D
L
--
D
---
S
T
-
I
E
T
E
P
L
M
P
P
Q
R
P
H
A
L
L
P
E
G
H
R
F
-
A
G
---
Q
A
Q
V
S
L
R
D
L
C
L
E
---
P
M
I
L
L
D
V
Q
P
S
-
R
T
-
Y
--
F
V
-
S
-
L
F
E
E
L
G
-
L
-
T
P
-
N
-
I
A
F
---
S
S
P
S
I
E
M
V
R
G
M
V
G
Q
-----
G
F
G
F
S
L
L
V
T
R
P
H
S
E
C
T
Y
D
G
K
K
V
V
M
V
D
L
A
E
-
P
-
V
-
S
T
S
G
L
A
-
A
A
W
L
K
R
A
Q
L
T
K
P
A
R
L
F
V
D
Y
C
R
E
Q
L
G
K
-----------------
44
Fugue
63.67
17%
-94
- C2 -
1IZ1
-
?
A:
[1-292]
-----
M
E
F
R
Q
L
K
Y
F
I
A
V
A
E
A
G
N
M
A
A
A
A
K
R
L
H
V
S
Q
P
P
I
T
R
Q
M
Q
A
L
E
A
D
L
G
V
V
L
L
E
R
S
H
R
G
I
E
L
T
A
A
G
H
A
F
L
E
D
A
R
R
I
L
E
-
L
A
G
R
S
G
D
R
S
R
A
A
A
-
R
G
D
V
G
-
E
L
S
V
A
Y
F
-
G
-
T
P
I
Y
R
S
L
P
L
L
L
R
A
F
L
T
S
T
P
T
A
T
V
S
L
T
H
M
T
K
--
D
--
E
Q
V
--
E
G
L
-
L
A
G
T
-
I
H
-
V
G
-
F
S
R
F
F
P
--
R
---
H
P
G
I
E
I
V
N
I
-
A
Q
E
D
L
Y
L
A
V
H
R
S
Q
S
G
-
K
F
---
G
K
T
C
K
L
A
D
L
R
A
V
---
E
-
L
T
L
F
P
R
G
G
-
R
P
S
F
--
A
D
-
E
-
V
I
G
L
F
K
-
H
-
A
G
-
I
-
E
P
R
---
I
A
R
V
V
E
-
D
A
T
-
A
A
L
A
L
T
M
A
G
A
A
S
S
I
V
P
A
S
V
A
A
I
R
W
P
D
---
I
A
-
F
A
R
I
V
-
G
-
T
-
R
V
K
V
P
I
-
S
C
I
F
R
K
E
K
Q
P
P
I
L
A
R
F
V
E
H
V
R
R
S
A
-------------------
50
Fugue
60.48
14%
-100
- C2 -
2ESN
-
?
A:
[3-303]
PLLR
R
L
D
L
N
L
L
L
V
F
D
A
L
Y
R
H
R
N
V
G
T
A
A
S
E
L
A
I
S
A
S
A
F
S
H
A
L
G
R
L
R
Q
G
L
D
D
E
L
F
L
R
Q
G
N
R
M
Q
P
T
Q
R
A
E
H
L
A
A
A
V
A
A
A
L
R
-
A
L
G
E
G
L
E
E
W
R
P
F
V
-
P
G
Q
S
Q
R
T
F
V
F
A
A
T
-
D
-
Y
T
A
F
A
L
L
P
P
L
M
N
R
L
Q
H
S
A
P
G
V
R
L
R
L
V
N
--
A
--
E
--
R
K
L
S
V
E
A
L
-
A
S
G
R
I
D
F
-
A
L
-
G
Y
D
E
E
H
ER
L
---
P
E
G
I
Q
A
H
D
W
-
F
A
D
R
Y
V
V
V
A
R
R
D
H
P
R
L
A
G
---
A
P
T
L
E
G
Y
L
A
E
R
H
---
A
-
V
V
T
P
W
N
E
D
-
S
G
-
V
--
I
D
-
R
-
L
L
A
R
S
G
L
R
-
R
E
-
V
-
A
V
Q
---
L
P
T
V
L
A
-
A
L
F
-
L
A
G
S
T
D
F
----
L
L
T
A
P
R
H
A
A
R
A
L
A
E
A
A
G
L
A
L
-
Y
P
A
P
F
-
D
-
I
-
P
P
Y
V
L
R
-
L
Y
S
H
V
Q
G
----------
R
D
A
H
A
W
M
I
G
Q
L
K
G
L
D
-----------
25
HHSearch
58.05
12%
-100
- C2 -
2ESN
-
?
A:
[7-303]
----
R
L
D
L
N
L
L
L
V
F
D
A
L
Y
R
H
R
N
V
G
T
A
A
S
E
L
A
I
S
A
S
A
F
S
H
A
L
G
R
L
R
Q
G
L
D
D
E
L
F
L
R
Q
G
N
R
M
Q
P
T
Q
R
A
E
H
L
A
A
A
V
A
A
A
L
R
-
A
L
G
E
G
L
E
E
W
R
P
F
V
P
G
Q
S
Q
R
-
T
F
V
F
A
A
T
-
D
-
Y
T
A
F
A
L
L
P
P
L
M
N
R
L
Q
H
S
A
P
G
V
R
L
R
L
V
N
--
A
--
E
RK
L
S
V
--
E
A
L
A
S
G
R
I
-
D
F
-
A
L
-
G
Y
D
E
-
E
--
H
ERL
P
E
G
I
Q
A
H
D
W
-
F
A
D
R
Y
V
V
V
A
R
R
D
H
P
R
-
L
A
---
G
-
A
P
T
L
E
G
Y
L
A
E
---
R
-
H
A
V
V
T
P
W
N
-
E
D
S
G
--
V
I
D
R
L
L
A
R
S
-----
G
L
---
R
R
E
---
V
A
V
Q
L
P
-
T
V
L
-
A
A
L
F
L
A
G
S
T
D
F
L
L
T
A
P
R
H
A
A
R
A
L
A
E
A
A
G
L
A
L
-
Y
P
A
P
F
-
D
-
I
-
P
P
Y
V
L
R
-
L
Y
S
H
V
Q
--
G
R
D
A
H
A
W
M
I
G
Q
L
K
G
L
D
-------------------
40
HHSearch
54.44
17%
-90
- C2 -
2FYI
-
CBL_ECOLI
A:
[89-296]
---------------------------------------------------------------------------------------------
N
D
T
S
G
-
V
L
T
I
A
T
T
-
H
-
T
Q
A
R
Y
S
L
P
E
V
I
K
A
F
R
E
L
F
P
E
V
R
L
E
L
I
Q
--
G
--
T
P
Q
E
I
A
--
T
L
L
Q
N
G
E
A
-
D
I
-
G
I
-
A
S
E
R
L
S
--
N
---
D
P
Q
L
V
A
F
P
W
-
F
R
W
H
H
S
L
L
V
P
H
D
H
P
L
-
T
Q
---
I
S
P
L
T
L
E
S
I
A
K
W
---
P
-
L
I
T
Y
R
Q
G
I
-
T
G
-
R
--
S
R
---
I
D
D
A
F
--
A
-
R
K
-
G
L
L
A
D
---
I
V
L
S
A
Q
-
D
S
D
-
V
I
K
T
Y
V
A
L
G
L
G
I
G
L
V
A
E
Q
S
S
G
E
Q
-
E
E
E
N
L
I
R
-
L
D
T
R
H
-
L
-
F
-
D
A
N
T
V
W
-
L
G
L
K
R
G
Q
L
Q
R
N
Y
V
W
R
F
L
E
L
C
N
A
G
L
S
V
E
D
I
K
R
Q
V
M
E
S
-------
42
HHSearch
53.71
15%
-122
- C2 -
2QSX
1
?
A:
[19-215]
-------------------------------------------------------------------------------------------------
E
-
L
L
V
V
D
V
T
-
P
-
S
F
A
S
L
W
L
V
P
N
I
N
D
F
H
Q
R
H
P
N
I
R
V
K
I
L
T
--
G
--
D
--
G
A
V
--------
E
S
-
D
L
-
H
V
-
R
C
L
P
-
L
--
S
---
T
H
Y
E
Y
S
Q
L
L
-
C
E
E
T
L
L
L
I
G
N
T
N
L
P
---------------
I
S
H
Y
---
P
-
F
I
P
Q
T
T
R
P
----
Q
--
L
W
-
E
Q
F
K
Q
E
N
------------ITY
H
S
V
G
F
E
-
H
F
Y
-
L
A
C
E
A
V
R
M
E
K
G
L
A
L
L
P
D
F
M
A
Q
F
S
I
L
R
G
D
I
Q
H
-
I
G
N
L
K
-
L
-
H
-
S
G
Y
G
Y
Y
-
V
V
I
P
N
F
R
L
T
S
R
K
V
A
L
F
H
D
W
L
K
D
K
L
T
------------------
29
HHSearch
52.85
16%
-97
- C2 -
1AL3
1
CYSB_KLEPN
A:
[88-298]
-------------------------------------------------------------------------------------------
T
-
W
P
D
K
G
-
S
L
Y
V
A
T
T
-
H
-
T
Q
A
R
Y
A
L
P
G
V
I
K
G
F
I
E
R
Y
P
R
V
S
L
H
M
H
Q
--
G
--
S
P
T
Q
I
A
--
E
A
V
S
K
G
N
A
-
D
F
-
A
I
-
A
T
E
A
-
L
--
H
L--
Y
D
D
L
V
M
L
P
C
-
Y
H
W
N
R
S
I
V
V
T
P
E
H
P
L
-
A
T
---
K
G
S
V
S
I
E
E
L
A
Q
Y
---
P
-
L
V
T
Y
T
F
G
F
-
T
G
-
R
--
S
E
---
L
D
T
A
F
--
N
-
R
A
-
G
L
T
P
R
---
I
V
F
T
A
T
-
D
A
D
-
V
I
K
T
Y
V
R
L
G
L
G
V
G
V
I
A
S
M
A
V
D
P
-
V
S
D
P
D
L
V
K
-
L
D
A
N
G
-
I
-
F
-
S
H
S
T
T
K
-
I
G
F
R
R
S
T
F
L
R
S
Y
M
Y
D
F
I
Q
R
F
A
P
H
L
T
R
D
V
V
D
T
A
V
A
L
R
S
N
E
D
I
E
A