@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0166: (2015-12-24 )
MHSEDQRPNDLIYGLDDRPRPLPAFLAALQHVLASFVGIVTPPLVIGSLLGLGEHLPYLISMALMVSGAGTLIQARRPFGIGAGMICLQGTSFAFLGAVLAAGMLVKQRGGGPEEILAMIFGVCFFGAFVQIVLSRFLGHLRRVITPLVTGIVITLIGVSLIKVGITDLGGGAGATDFGAPANLALGALVLLSIVLLNRSRLPWLRLAAIVIGLALGTLAAWATGLFVPRALPELPLVSLPQPFRFGFAFDWMAFLPVALIYLISSIETVGDLTANCMLSRQPLEGPAYLQRLRGGVLGDGVSCLLAATFSAFPNTTFAQNNGVIQLTGVASRHVGIYIGGVLLALGLFPWVGAILQQIPKPVLGGATLVMFGSVAAAGIRILGQTAMDRRSVLIIAASFGVGLGVAAQPTLLDQMPAVVKTLFDSAITSGGITAILLNLLLPEERVAEAAQASAKGGALARWRKPLG
Atome Classification :
(16 SA)
--.......--..10.---.......20...-.....30........40...--.....50........60........70........80-..---......90........100.......110.......120.......130.....----..-140.......150-.......160-........170.......180.......190.......200.-......210.......220.......230....----...240.......250.......260.......270.......280.......290.......300.......310.-.......320.....---.--.330........340.......350-...---......360.......370.......380.......---390-------........400.....-..410....------...420.......430..--..--...440.......450.......460......
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
--MHSEDQR--PND
L
I
---YGLDDRPR
P
L
P
A
-
F
L
A
A
L
Q
H
V
L
A
S
F
V
GIVT
P
P
L
--
V
I
G
S
L
L
G
LGEH
L
P
Y
L
I
S
M
A
L
M
VSGA
G
T
L
I
Q
ARRPFGI-GA---
G
M
I
C
LQG
T
S
F
A
F
L
G
A
V
L
A
A
G
M
L
V
KQRGG
G
P
E
E
I
L
A
M
I
F
G
V
C
F
F
G
A
F
V
Q
I
V
L
S
R
F
----
L
G
-
H
L
R
R
V
I
T
P
L
V
T
G
I
-
V
I
T
L
I
G
V
S
L
--
I
K
V
G
I
TDLGGGAGATDFGA
P
A
N
L
A
L
G
A
L
V
L
L
S
I
V
L
LNRSR
L
P
-
W
L
R
L
A
A
I
V
I
G
L
A
L
G
T
L
A
A
W
A
TGLFVPRALPELP----LVSLPQPFRFG
F
A
F
D
W
M
A
F
L
P
V
A
L
I
Y
L
I
S
S
I
E
T
V
G
D
L
T
A
N
C
MLSRQPLE
G
P
A
Y
L
Q
R
L
RGGVLG
D
G
V
S
C
L
L
A
A
T
F
-
S
A-FPNTTFAQNN
G
V
I
Q
L
---T--GV-ASR
H
V
G
I
Y
I
G
G
V
L
L
A
L
G
L
F
P
---
W
V
G
---
A
I
L
Q
QIP
K
P
VLG
G
A
T
L
V
M
FG
S
V
A
A
A
G
I
R
I
L
G
QTAMD---R
R
--------
S
V
L
I
I
A
ASFGVGLGVA-AQ
P
T
L
L
D
Q
M
------
P
A
V
V
K
T
L
F
D
S
A
ITSG
G
I
T
--
A
I
--
L
L
N
L
LL
P
E
E
R
V
A
E
A
A
Q
ASAKGGA
L
A
R
WRKPLG
1
PsiBlast_PDB
87.30
26%
-123
- C4 -
3QE7
2
URAA_ECOLI
A:
[7-410]
--------------------
G
V
S
E
R
P
P
L
L
Q
T
-
I
P
L
S
L
Q
H
L
F
A
M
F
G
A
T
V
L
V
P
V
--
L
F
--------
H
I
N
P
--
A
T
V
L
L
F
N
G
I
G
T
L
L
Y
L
---
F
I
C
-
K
G
---
K
I
P
A
Y
L
G
S
S
F
A
F
I
S
P
V
L
L
L
L
P
L
G
Y
E
V
A
L
G
G
F
I
M
C
G
V
L
F
C
L
V
S
F
-----
I
V
K
K
A
G
----
T
G
-
W
L
D
V
L
F
P
P
A
A
M
G
A
-
I
V
A
V
I
G
L
E
L
A
G
V
A
A
G
M
A
G
L
L
P
A
E
G
Q
T
P
---
D
S
K
T
I
I
I
S
I
T
T
L
A
V
T
V
L
G
S
V
L
F
R
G
F
L
A
I
I
P
I
L
I
G
V
L
V
G
Y
A
L
S
F
A
M
G
I
V
D
T
T
P
I
I
N
A
H
----
W
F
A
L
P
T
--
L
Y
T
P
R
F
E
W
F
A
I
L
T
I
L
P
A
A
L
V
V
I
A
E
H
V
G
H
L
V
V
T
A
N
I
V
K
K
D
L
L
R
D
P
G
L
H
R
---
S
M
F
A
N
G
L
S
T
V
I
S
G
F
F
-
G
S
-
T
P
N
T
T
Y
G
E
N
I
G
V
M
A
I
---
T
--
R
V
-
Y
S
T
W
V
---
I
G
G
A
A
I
F
A
I
L
L
S
---
C
V
G
K
L
A
A
A
I
Q
M
I
P
L
P
V
M
G
G
V
S
L
L
L
Y
G
V
I
G
A
S
G
I
R
V
L
I
E
S
K
V
D
---
Y
N
K
A
Q
N
L
I
L
T
S
V
I
L
I
I
G
V
S
G
A
K
V
N
I
G
-
A
---------------
A
E
L
K
G
M
A
L
A
T
I
V
G
I
G
L
S
--
L
I
F
K
L
I
S
-----------------------------
14
Fugue
86.53
24%
-128
- C4 -
3QE7
2
URAA_ECOLI
A:
[4-410]
--------------
R
A
---
I
G
V
S
E
R
P
P
L
L
Q
T
-
I
P
L
S
L
Q
H
L
F
A
M
F
G
A
T
V
L
V
P
V
--
L
F
H
----------
I
N
P
A
T
V
L
L
F
N
G
I
G
T
L
L
Y
L
F
I
C
----
K
G
---
K
I
P
A
Y
L
G
S
S
F
A
F
I
S
P
V
L
L
L
L
P
L
-----
G
Y
E
V
A
L
G
G
F
I
M
C
G
V
L
F
C
L
V
S
F
I
V
K
K
A
G
----
T
G
-
W
L
D
V
L
F
P
P
A
A
M
G
A
-
I
V
A
V
I
G
L
E
L
--
A
G
V
A
A
G
M
A
G
L
L
P
A
E
G
Q
T
P
D
S
K
T
I
I
I
S
I
T
T
L
A
V
T
V
L
G
S
V
L
F
R
G
-
F
L
A
I
I
P
I
L
I
G
V
L
V
G
Y
A
L
S
F
A
M
G
I
V
D
T
T
P
I
I
N
A
H
----
W
F
A
L
P
T
L
Y
T
P
--
R
F
E
W
F
A
I
L
T
I
L
P
A
A
L
V
V
I
A
E
H
V
G
H
L
V
V
T
A
N
I
V
K
K
D
L
L
R
D
P
---
G
L
H
R
S
M
F
A
N
G
L
S
T
V
I
S
G
F
F
-
G
S
-
T
P
N
T
T
Y
G
E
N
I
G
V
M
A
I
---
T
--
R
V
-
Y
S
T
W
V
I
G
G
A
A
I
F
A
I
L
L
S
C
V
G
---
K
L
A
---
A
A
I
Q
M
I
P
L
P
V
M
G
G
V
S
L
L
L
Y
G
V
I
G
A
S
G
I
R
V
L
I
E
S
K
V
D
YNK
A
Q
--------
N
L
I
L
T
S
V
I
L
I
I
G
V
S
G
A
-
K
V
N
I
G
A
A
E
L
---------------
K
G
M
A
L
A
T
I
V
--
G
I
--
G
L
S
L
I
F
K
L
I
S
----------------------
7
HHSearch
86.14
24%
-134
- C4 -
3QE7
2
URAA_ECOLI
A:
[4-410]
--------------
R
A
---
I
G
V
S
E
R
P
P
L
L
Q
T
-
I
P
L
S
L
Q
H
L
F
A
M
F
G
A
T
V
L
V
P
V
--
L
F
H
----------
I
N
P
A
T
V
L
L
F
N
G
I
G
T
L
L
Y
L
F
----
I
C
K
G
---
K
I
P
A
Y
L
G
S
S
F
A
F
I
S
P
V
L
L
L
L
----------
P
L
G
Y
E
V
A
L
G
G
F
I
M
C
G
V
L
F
C
L
V
S
F
I
V
K
K
A
G
T
G
W
L
D
V
L
F
P
P
A
A
M
G
A
-
I
V
A
V
I
G
L
E
L
--
A
G
V
A
A
G
M
A
G
L
L
P
A
E
G
Q
T
P
D
S
K
T
I
I
I
S
I
T
T
L
A
V
T
V
L
G
S
V
L
F
R
G
-
F
L
A
I
I
P
I
L
I
G
V
L
V
G
Y
A
L
S
F
A
M
G
I
V
D
T
T
P
I
I
N
A
H
----
W
F
A
L
P
T
L
Y
T
P
--
R
F
E
W
F
A
I
L
T
I
L
P
A
A
L
V
V
I
A
E
H
V
G
H
L
V
V
T
A
N
I
V
K
K
D
L
---
L
R
D
P
G
L
H
R
S
M
F
A
N
G
L
S
T
V
I
S
G
F
F
-
G
S
-
T
P
N
T
T
Y
G
E
N
I
G
V
M
A
I
---
T
--
R
V
-
Y
S
T
W
V
I
G
G
A
A
I
F
A
I
L
L
S
C
V
G
---
K
L
A
---
A
A
I
Q
M
I
P
L
P
V
M
G
G
V
S
L
L
L
Y
G
V
I
G
A
S
G
I
R
V
L
I
E
S
K
V
D
YNK
A
Q
--------
N
L
I
L
T
S
V
I
L
I
I
G
V
S
G
A
-
K
V
N
I
G
A
A
---------------
E
L
K
G
M
A
L
A
T
I
V
--
G
I
--
G
L
S
L
I
F
K
L
I
S
----------------------
22
Fugue
62.01
17%
-117
- C2 -
4QLA
1
HYEP_BOMMO
A:
[19-442]
---
L
D
L
E
E
W
WG
P
P
E
L
K
---
Q
K
Q
D
T
S
I
K
P
F
E
I
T
F
S
E
T
M
V
K
E
L
K
E
R
I
K
K
R
R
P
F
A
--
P
P
L
E
G
V
G
F
K
Y
G
F
N
S
K
Q
L
D
S
W
L
K
Y
W
A
E
E
Y
P
F
A
E
R
Q
K
F
L
-
N
Q
Y
P
H
F
K
T
N
I
Q
G
L
N
I
H
F
M
R
I
--------
T
P
K
V
P
K
G
V
E
I
V
P
L
L
L
L
H
G
W
P
G
S
V
R
E
--
F
Y
E
A
----
I
P
-
H
L
T
A
V
--
S
K
D
R
N
F
-
A
L
E
I
I
A
P
S
L
--
P
---------
G
Y
G
F
S
D
A
A
V
R
P
G
L
A
A
A
E
V
A
V
I
F
K
N
L
M
A
R
L
G
Y
K
-----
Q
Y
Y
V
Q
G
G
D
W
G
A
L
I
G
S
A
M
A
T
F
F
P
K
E
I
I
G
F
H
S
N
M
A
L
T
L
S
P
A
A
T
F
L
E
F
V
G
A
L
F
P
S
L
I
V
E
P
-
E
L
A
N
R
L
Y
P
L
S
E
K
Y
S
T
L
L
E
E
L
G
Y
M
H
I
Q
A
T
K
P
D
T
V
G
I
G
L
T
D
S
P
A
G
L
L
A
Y
I
L
-
E
K
-
F
S
T
W
T
N
P
D
L
R
S
--
K
E
---
D
--
G
G
-
L
S
----------------
Y
R
---
W
T
----------
K
D
Q
L
I
D
N
L
M
L
Y
W
S
T
K
S
I
V
T
S
M
R
L
Y
A
E
S
F
S
S
---
R
H
F
-------
D
L
K
L
D
E
I
Q
V
Q
V
P
T
W
V
L
Q
A
K
H
E
L
A
Y
Q
P
------
P
C
I
L
K
M
K
Y
P
K
L
V
N
A
S
V
I
E
DG
G
H
--
F
L
A
F
E
L
P
E
I
F
A
K
D
V
L
K
A
I
G
E
F
R
K
L
K
N
------
19
Fugue
58.91
14%
-74
- C4 -
4MT0
1
?
A:
[1-445]
CT
M
I
P
Q
Y
E
Q
--
P
K
V
E
V
AET
F
Q
N
D
T
S
V
S
S
I
R
A
-
V
D
L
G
W
H
D
Y
F
A
D
------
P
R
L
Q
K
L
I
D
I
A
L
E
R
N
T
S
L
R
T
A
V
L
N
S
E
I
Y
R
K
Q
Y
M
I
E
R
N
N
L
L
P
T
L
-
A
A
---
N
A
N
G
S
R
Q
G
S
L
S
--
G
G
N
V
S
S
S
Y
N
V
G
L
G
A
A
S
Y
E
L
D
L
--------
F
G
R
V
R
S
S
S
E
A
A
L
----
Q
G
-
Y
F
A
S
V
A
N
R
D
A
A
H
L
S
L
I
A
T
V
A
K
A
Y
--
F
N
E
R
Y
A
E
E
A
M
S
L
A
Q
R
V
L
K
T
R
E
E
T
Y
N
A
V
R
I
--
A
V
Q
G
R
R
D
F
R
R
R
-
P
A
P
A
E
A
L
I
E
S
A
K
A
D
Y
A
H
A
A
R
S
R
E
Q
A
R
N
A
L
A
T
L
I
----
N
R
P
I
P
E
D
L
P
A
G
L
P
L
D
K
Q
F
F
V
E
----------
K
L
P
A
G
L
S
S
E
V
L
L
D
R
P
D
I
R
A
A
E
H
A
L
K
Q
A
N
A
N
I
G
A
A
-----
R
A
A
F
-
F
P
-
S
I
R
L
T
G
S
V
G
T
G
S
V
E
L
---
G
--
G
L
-
F
K
S
G
T
G
V
W
A
F
A
P
S
I
T
L
P
I
F
T
---
W
G
T
---
N
K
A
N
L
D
V
A
K
L
R
Q
Q
A
Q
I
V
A
Y
E
S
A
V
Q
S
A
F
Q
D
V
A
N
A
L
A
A
---
R
E
--------
Q
L
D
K
A
Y
D
A
L
S
K
Q
S
R
A
S
-
K
E
A
L
R
L
V
G
L
R
Y
K
HGV
S
G
A
L
D
L
L
D
A
E
R
S
S
Y
S
A
E
G
--
A
A
--
L
S
A
Q
L
T
R
A
E
N
L
A
D
L
Y
K
A
L
--
G
G
G
L
K
R
D
T
Q
T
--
20
Fugue
38.75
26%
351
* C4 *
2XZE
-
CHMP3_HUMAN
Q:
[18-40]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
E
D
E
E
E
E
E
E
A
L
E
A
M
Q
S
R
L
A
T
L
R
S
---
18
Fugue
32.83
15%
56
- C4 -
1F02
-
?
T:
[271-336]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
D
Q
A
A
N
A
A
-
E
S
A
T
K
D
Q
L
T
------
Q
E
A
F
K
N
P
E
N
Q
K
V
N
I
D
A
N
G
--
N
A
--
I
P
S
G
E
L
K
D
D
I
V
E
Q
I
A
Q
Q
A
K
E
A
G
E
V
A
R
Q
Q
A
---
15
Fugue
32.02
36%
379
- C4 -
4GEQ
-
F:
[2-20]
-----------------------
K
D
P
N
E
V
R
S
-
F
L
Q
D
L
S
Q
V
L
A
R
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
4
PsiBlast_PDB
29.79
27%
-14
- C4 -
4AGF
-
MSCS_ECOLI
A:
[70-127]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
L
V
R
Y
G
I
I
A
F
T
L
I
A
A
L
G
R
V
G
V
Q
---
T
A
--------
S
V
I
A
V
L
G
A
A
G
L
A
V
G
L
A
-
L
Q
G
S
L
S
N
L
A
------
A
G
V
L
C
V
M
F
R
P
F
R
A
G
E
Y
V
D
--
L
G
--
G
V
A
G
T
V
L
S
V
Q
I
F
S
T
T
M
R
T
A
D
G
K
I
I
V
I
P
N
G
K
I
I
6
PsiBlast_PDB
29.25
27%
-4
- C4 -
4HWA
-
MSCS_ECOLI
A:
[70-127]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
L
V
R
Y
G
I
I
A
F
T
L
I
A
A
L
G
R
V
G
V
Q
---
T
A
--------
S
V
I
A
V
L
G
A
A
G
L
A
V
G
L
A
-
L
Q
G
S
L
S
N
L
A
------
A
G
V
L
L
V
M
F
R
P
F
R
A
G
E
Y
V
D
--
L
G
--
G
V
A
G
T
V
L
S
V
Q
I
F
S
T
T
M
R
T
A
D
G
K
I
I
V
I
P
N
G
K
I
I
3
PsiBlast_PDB
29.24
27%
-14
- C4 -
4AGE
-
MSCS_ECOLI
A:
[70-127]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
L
V
R
Y
G
I
I
A
F
T
L
I
A
A
L
G
R
V
G
V
Q
---
T
A
--------
S
V
I
A
V
L
G
A
A
G
L
A
V
G
L
A
-
L
Q
G
S
L
S
N
L
A
------
A
G
V
L
L
V
M
F
R
P
F
R
A
G
E
Y
V
D
--
L
G
--
G
V
A
G
T
V
L
S
V
Q
I
F
S
T
T
M
R
T
A
D
G
K
I
I
V
I
P
N
G
K
I
I
2
PsiBlast_PDB
29.13
27%
-12
- C4 -
5AJI
1
?
A:
[70-127]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
L
V
R
Y
G
I
I
A
F
T
L
I
A
A
L
G
R
V
G
V
Q
---
T
A
--------
S
V
I
A
V
L
G
A
A
G
L
A
V
G
L
A
-
L
Q
G
S
L
S
N
L
A
------
A
G
V
L
L
V
M
F
R
P
F
R
A
G
E
Y
V
D
--
L
G
--
G
V
A
G
T
V
L
S
V
Q
I
F
S
T
T
M
R
T
A
D
G
K
I
I
V
I
P
N
G
K
I
I
5
PsiBlast_PDB
27.06
27%
9
- C4 -
2OAU
-
MSCS_ECOLI
A:
[70-127]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
A
L
V
R
Y
G
I
I
A
F
T
L
I
A
A
L
G
R
V
G
V
Q
---
T
A
--------
S
V
I
A
V
L
G
A
A
G
L
A
V
G
L
A
-
L
Q
G
S
L
S
N
L
A
------
A
G
V
L
L
V
M
F
R
P
F
R
A
G
E
Y
V
D
--
L
G
--
G
V
A
G
T
V
L
S
V
Q
I
F
S
T
T
M
R
T
A
D
G
K
I
I
V
I
P
N
G
K
I
I
8
HHSearch
25.75
14%
-13
- C4 -
3QE7
2
URAA_ECOLI
A:
[43-130]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
A
T
V
L
L
F
N
G
I
G
T
L
L
Y
L
F
I
C
K
G
K
I
P
A
Y
L
G
S
S
F
A
F
I
S
P
V
L
L
L
L
PL
G
Y
E
V
A
L
G
G
F
I
M
C
G
V
L
F
C
L
V
S
F
I
V
K
K
A
G
T
G
---
W
L
D
V
L
F
P
P
A
A
M
G
A
I
V
A
V
I
G
L
E
L
A
G
V
A
A
G
M
A
G
L
L
P
A
E
---
G
Q
--------
T
P
D
S
K
T
I
I
I
S
I
T
T
L
A
V
-
T
V
L
G
S
V
L
F
R
------
G
F
L
A
I
I
P
I
L
I
G
V
L
V
G
Y
A
L
--
S
F
--
A
M
G
I
V
D
T
T
P
I
I
N
A
H
W
F
A
L
P
T
L
Y
T
P
R
F
E
W
F
A
I
L
10
HHSearch
24.86
21%
701
- C3 -
3UKW
1
?
C:
[7-23]
-------
P
R
--
K
R
P
L
E
---
W
D
E
D
E
E
P
P
R
K
R
K
-
R
L
W
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
13
HHSearch
15.23
17%
2372
- C1 -
1C4E
-
GUR_GYMSY
A:
[25-30]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
V
N
W
W
D
H
K
C
I