@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0181: (2015-12-25 )
METLSNIQCFVRSAEAGSFAEAARRLGLTPAGVGKNVARLESNLGVRLFQRSTRRLTLTEAGERFLQEVGGSLEGIQTALANVSSVGNQPSGTLKVSMGLAFGRDYILPLLGEFLERYPDIVPDWHFDNRQVDLIGEGFDAAIGGGFELPPGVVARNLTPGHLILLASPTYLRDKPPIRHPGDLGGFDGIRIRSPQTGRVRSWPLRRRNGEEAPIELRERMTMSDPEATCEVAAMGLGITLVCMQHAYAYLESGALVRVLPDWYVDAGNTSLYYAANKLLPAKTRVFVDFVVDYFRRQDLARRFSAFPTG
Atome Classification :
(20 SA)
----.........10........20........30........40........50........60........70...-.....80......-..90.-.......-100........110.......120.....---..--.130-...--.....-.140..---...-.-.--150......-.160.-......170...-....-180..-....-.190.......200.-......210...-....220.......-.-230-..--.-....240....-...--250...-...-.260-..-.-....--270.......280..-.....290.......300.......310
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
----MET
L
S
N
I
Q
C
F
V
RSAEAG
S
F
A
E
A
A
R
RLGLTPAGVG
K
N
V
A
R
L
E
SNLG
V
R
L
F
Q
RST
R
R
L
T
L
T
E
A
G
E
R
F
L
Q
E
VGG
S
L
E
-
G
I
Q
T
A
L
A
N
V
S
SVG-NQPS
G
-
T
L
K
V
S
MG-L-AF
G
R
D
Y
I
L
P
L
L
G
E
F
L
E
RYPDI-VPDWH---FD--N
R
---
Q
V
D
--
L
IGEG-F
D
A
AIG---GGF-E-L--
P
P
G
V
V
ARNL-TPG
H
L
-
I
L
LASPTYLRDK-PPIR-HPGDL-GGFD-
G
I
R
IRSPQTGRVRSW-PLRRRNGEEA
P
I
-
E
L
R
E
RM-TMSD
P
E
A
-
T
-
C
E
V
-
A
A
--M-G
L
G
I
T
L
V
C
M
Q
H
-
A
Y
A
--
Y
L
ESG
A
-
L
V
R
-VLPD-
W
Y
-V-DAGN--
T
S
L
Y
Y
AANKLLPA
K
T
-
R
V
F
V
D
F
V
V
D
Y
F
R
R
Q
D
L
A
R
R
F
SAFPTG--
27
HHSearch
88.24
29%
-113
- C1 -
3SZP
-
?
A:
[1-289]
-----
M
K
L
D
D
L
N
L
F
R
L
V
V
E
N
G
S
Y
T
S
T
S
K
K
T
M
I
P
V
A
T
I
T
R
R
I
Q
A
L
E
D
S
L
N
L
R
L
L
N
R
H
A
R
K
L
T
L
T
E
A
G
E
R
F
Y
K
D
C
S
P
L
L
E
-
R
L
A
S
M
T
E
E
I
T
D
E
C
-
R
G
A
S
G
-
R
I
R
I
S
A
P
-
S
-
N
L
T
K
R
M
M
M
P
M
F
N
A
F
M
E
K
Y
P
D
I
-
H
I
E
L
M
---
M
S
--
N
Q
---
A
D
D
--
L
D
P
T
E
-
W
D
V
I
F
R
---
V
G
P
Q
R
----
D
S
S
L
I
A
R
K
I
-
G
E
V
K
D
-
I
L
V
A
S
P
Q
Y
L
S
S
H
-
P
Q
P
T
-
H
A
E
E
L
-
H
Q
H
Q
-
L
L
K
G
Y
P
L
-----
L
K
W
-
Q
L
T
N
S
Q
G
E
T
V
V
N
-
S
D
R
G
R
F
-
Q
A
S
A
L
N
V
-
V
-
R
S
A
-
C
S
--
E
-
G
L
G
I
T
L
M
P
D
V
M
-
L
R
E
--
F
L
E
D
G
S
-
L
V
Q
-
V
L
S
D
-
W
S
-
S
-
N
P
R
D
--
I
Y
M
L
Y
N
H
K
D
H
Q
P
E
K
V
-
R
L
F
I
D
F
V
I
G
Y
H
L
----------------
2
PsiBlast_PDB
87.27
28%
-109
- C1 -
3T1B
-
?
B:
[3-288]
-------
L
D
D
L
N
L
F
R
L
V
V
E
N
G
S
Y
T
S
T
S
K
K
T
M
I
P
V
A
T
I
T
R
R
I
Q
A
L
E
D
S
L
N
L
R
L
L
N
R
H
A
R
K
L
T
L
T
E
A
G
E
R
F
Y
K
D
C
S
P
L
L
E
-
R
L
A
S
M
T
E
E
I
T
D
E
C
-
R
G
A
S
G
-
R
I
R
I
S
A
P
-
S
-
E
L
T
K
R
M
M
M
P
M
F
N
A
F
M
E
K
Y
P
D
I
-
H
I
E
L
M
---
M
S
--
N
Q
---
A
D
---
L
D
P
T
E
-
W
D
V
I
F
R
---
V
G
P
-
Q
-
R
--
D
S
S
L
I
A
R
K
I
-
G
E
V
K
D
-
I
L
V
A
S
P
Q
Y
L
S
S
H
-
P
Q
P
T
-
H
A
E
E
L
-
H
Q
H
Q
-
L
L
K
-----
G
Y
P
L
L
K
W
-
Q
L
T
N
S
Q
G
E
T
V
V
N
-
S
D
R
G
R
F
-
Q
A
S
A
L
N
V
-
V
-
R
S
A
-
C
S
--
E
-
G
L
G
I
T
L
M
P
D
V
M
-
L
R
E
--
F
L
E
D
G
S
-
L
V
Q
-
V
L
S
D
-
W
S
-
S
-
N
P
R
D
--
I
Y
M
L
Y
N
H
K
D
H
Q
P
E
K
V
-
R
L
F
I
D
F
V
I
G
Y
H
L
----------------
3
PsiBlast_PDB
86.44
28%
-113
- C1 -
3SZP
-
?
A:
[3-288]
-------
L
D
D
L
N
L
F
R
L
V
V
E
N
G
S
Y
T
S
T
S
K
K
T
M
I
P
V
A
T
I
T
R
R
I
Q
A
L
E
D
S
L
N
L
R
L
L
N
R
H
A
R
K
L
T
L
T
E
A
G
E
R
F
Y
K
D
C
S
P
L
L
E
-
R
L
A
S
M
T
E
E
I
T
D
E
C
-
R
G
A
S
G
-
R
I
R
I
S
A
P
-
S
-
N
L
T
K
R
M
M
M
P
M
F
N
A
F
M
E
K
Y
P
D
I
-
H
I
E
L
M
---
M
S
--
N
Q
---
A
D
D
--
L
D
P
T
E
-
W
D
V
I
F
R
---
V
G
P
-
Q
-
R
--
D
S
S
L
I
A
R
K
I
-
G
E
V
K
D
-
I
L
V
A
S
P
Q
Y
L
S
S
H
-
P
Q
P
T
-
H
A
E
E
L
-
H
Q
H
Q
-
L
L
K
-----
G
Y
P
L
L
K
W
-
Q
L
T
N
S
Q
G
E
T
V
V
N
-
S
D
R
G
R
F
-
Q
A
S
A
L
N
V
-
V
-
R
S
A
-
C
S
--
E
-
G
L
G
I
T
L
M
P
D
V
M
-
L
R
E
--
F
L
E
D
G
S
-
L
V
Q
-
V
L
S
D
-
W
S
-
S
-
N
P
R
D
--
I
Y
M
L
Y
N
H
K
D
H
Q
P
E
K
V
-
R
L
F
I
D
F
V
I
G
Y
H
L
----------------
4
PsiBlast_PDB
84.40
28%
-113
- C1 -
3HHG
-
?
A:
[8-291]
----------
L
T
V
F
V
Q
V
V
E
S
G
S
F
S
R
A
A
E
Q
L
A
M
A
N
S
A
V
S
R
I
V
K
R
L
E
E
K
L
G
V
N
L
L
N
R
T
T
R
Q
L
S
L
T
E
E
G
A
Q
Y
F
R
R
A
Q
R
I
L
Q
-
E
M
A
A
A
E
T
E
M
L
A
V
H
-
E
I
P
Q
G
-
V
L
S
V
D
S
A
-
M
-
P
M
V
L
H
L
L
A
P
L
A
A
K
F
N
E
R
Y
P
H
I
-
R
L
S
L
V
---
S
S
--
E
G
---
Y
I
N
--
L
I
E
R
K
-
V
D
I
A
L
R
---
A
G
E
-
L
-
D
--
D
S
G
L
R
A
R
H
L
-
F
D
S
R
F
-
R
V
I
A
S
P
E
Y
L
A
K
H
-
G
T
P
Q
-
S
T
E
E
L
-
A
G
H
Q
-
C
L
G
F
T
E
P
--
G
S
L
N
T
W
-
A
V
L
D
A
Q
G
N
--
P
Y
-
K
I
S
P
H
F
-
T
A
S
S
G
E
I
-
L
-
R
S
L
-
C
L
--
S
-
G
C
G
I
--
V
C
L
S
D
-
F
L
V
D
N
D
I
A
E
G
K
-
L
I
P
-
L
L
A
E
-
Q
T
-
S
-
D
K
T
H
P
F
N
A
V
Y
Y
-
S
D
K
A
V
N
L
R
L
-
R
V
F
L
D
F
L
V
E
E
L
G
----------------
26
HHSearch
83.79
26%
-107
- C1 -
3HHG
-
?
A:
[2-294]
----
K
T
N
S
E
E
L
T
V
F
V
Q
V
V
E
S
G
S
F
S
R
A
A
E
Q
L
A
M
A
N
S
A
V
S
R
I
V
K
R
L
E
E
K
L
G
V
N
L
L
N
R
T
T
R
Q
L
S
L
T
E
E
G
A
Q
Y
F
R
R
A
Q
R
I
L
Q
-
E
M
A
A
A
E
T
E
M
L
A
V
H
-
E
I
P
Q
G
-
V
L
S
V
D
S
A
-
M
-
P
M
V
L
H
L
L
A
P
L
A
A
K
F
N
E
R
Y
P
H
I
-
R
L
S
L
V
---
S
S
--
E
G
---
Y
I
N
--
L
I
E
R
K
-
V
D
I
A
L
R
---
A
G
E
L
D
----
D
S
G
L
R
A
R
H
L
-
F
D
S
R
F
-
R
V
I
A
S
P
E
Y
L
A
K
H
-
G
T
P
Q
-
S
T
E
E
L
-
A
G
H
Q
-
C
L
G
F
T
E
P
G
S
--
L
N
T
W
-
A
V
L
D
A
Q
G
--
N
P
Y
-
K
I
S
P
H
F
-
T
A
S
S
G
E
I
-
L
-
R
S
L
-
C
L
--
S
-
G
C
G
I
V
C
L
S
D
F
L
-
V
D
N
--
D
I
A
E
G
K
-
L
I
P
-
L
L
A
E
-
Q
T
S
D
-
K
T
H
P
--
F
N
A
V
Y
Y
S
D
K
A
V
N
L
R
L
-
R
V
F
L
D
F
L
V
E
E
L
G
----------------
49
Fugue
70.43
21%
-82
- C1 -
1IZ1
-
?
A:
[1-292]
-----
M
E
F
R
Q
L
K
Y
F
I
A
V
A
E
A
G
N
M
A
A
A
A
K
R
L
H
V
S
Q
P
P
I
T
R
Q
M
Q
A
L
E
A
D
L
G
V
V
L
L
E
R
S
H
R
G
I
E
L
T
A
A
G
H
A
F
L
E
D
A
R
R
I
L
E
-
L
A
G
R
S
G
D
R
S
R
A
A
A
-
R
G
D
V
G
-
E
L
S
V
A
Y
F
-
G
-
T
P
I
Y
R
S
L
P
L
L
L
R
A
F
L
T
S
T
P
T
A
-
T
V
S
L
T
H
M
-
T
K
--
D
E
---
Q
V
E
--
G
L
L
A
G
T
I
H
V
G
F
S
---
R
F
F
-
P
-
R
--
H
P
G
I
E
I
V
N
I
-
A
Q
E
D
L
-
Y
L
A
V
H
R
S
Q
S
G
K
F
-
G
K
T
C
-
K
L
A
D
L
-
R
A
V
E
-
L
T
L
F
--
P
R
G
G
R
P
S
F
A
-
D
E
V
I
G
L
F
K
H
A
G
I
-
E
P
R
I
A
R
-
V
V
E
D
A
T
A
-
A
-
L
A
L
-
T
M
--
A
-
G
A
A
S
S
I
V
P
-
A
S
-
V
A
A
--
I
R
W
P
D
I
-
A
F
A
-
R
I
V
G
------------------------
T
R
V
-
K
V
P
I
S
C
I
F
R
K
E
K
Q
P
P
I
L
A
R
F
V
E
H
V
R
R
S
A
50
Fugue
69.03
19%
-81
- C1 -
3ISP
-
Y1985_MYCTU
A:
[5-296]
----
Q
L
D
G
P
Q
L
A
A
L
A
A
V
V
E
L
G
S
F
D
A
A
A
E
R
L
H
V
T
P
S
A
V
S
Q
R
I
K
S
L
E
Q
Q
V
G
Q
V
L
V
V
R
E
-
K
P
C
R
A
T
T
A
G
I
P
L
L
R
L
A
A
-------
Q
T
A
L
L
E
S
E
A
L
A
-
E
M
G
A
S
-
L
K
R
T
R
I
T
-
I
-
A
V
N
A
D
S
M
A
T
W
F
S
A
V
F
D
G
L
G
D
V
-
L
L
D
V
R
---
I
E
D
Q
D
H
---
S
A
R
--
L
L
R
E
G
V
A
M
G
A
V
T
---
T
E
R
-
N
-
P
--
V
P
G
C
R
V
H
P
L
-
G
E
M
R
Y
-
L
P
V
A
S
R
P
F
V
Q
R
H
-
L
S
D
G
F
T
A
A
A
A
-
A
K
A
P
-
S
L
A
W
N
R
D
D
G
L
Q
D
M
L
V
-
R
K
A
F
R
R
A
I
T
R
P
------
T
H
-
F
V
P
T
T
E
G
-
F
-
T
A
A
-
A
R
--
A
-
G
L
G
W
G
M
F
P
E
K
L
-
A
A
S
--
P
L
A
D
G
S
-
F
V
R
-
V
C
D
I
-------
H
L
D
--
V
P
L
Y
W
Q
C
W
K
L
D
S
P
I
I
-
A
R
I
T
D
T
V
R
A
A
A
S
G
L
--------
Y
R
G
Q
--
1
PsiBlast_PDB
68.29
31%
-108
- C1 -
3MZ1
-
?
A:
[85-288]
----------------------------------------------------------------------------------------------
L
P
K
G
-
R
L
R
V
E
T
A
-
S
-
A
F
A
N
L
V
I
I
P
A
L
P
E
F
H
K
K
Y
P
D
I
-
Q
I
D
L
G
---
V
S
--
D
R
---
T
----
Y
L
A
E
N
-
V
D
C
A
I
R
---
A
G
T
-
L
-
T
--
D
Q
S
L
I
A
R
R
I
-
T
E
M
K
F
-
V
A
C
A
S
R
D
F
L
E
R
H
-
P
V
P
Q
-
H
P
S
D
L
E
K
N
C
Y
-
V
V
G
Y
F
L
P
K
--
Q
Q
M
P
F
-
H
F
R
R
G
N
E
E
---
I
-
E
V
S
G
R
Y
-
T
M
A
A
N
E
S
-
T
-
T
Y
L
-
A
A
A
R
A
-
G
L
G
V
I
Q
A
P
L
F
M
-
V
R
E
--
D
L
R
N
G
T
-
M
V
P
-
V
L
P
D
-
W
Q
-
V
-
E
P
M
P
--
I
Y
L
V
Y
P
P
N
R
H
L
S
S
R
L
-
R
V
F
A
D
W
V
V
K
V
M
A
Q
S
Q
N
------------
32
HHSearch
68.17
29%
-105
- C1 -
3MZ1
-
?
A:
[85-294]
----------------------------------------------------------------------------------------------
L
P
K
G
-
R
L
R
V
E
T
A
-
S
-
A
F
A
N
L
V
I
I
P
A
L
P
E
F
H
K
K
Y
P
D
I
-
Q
I
D
L
G
---
V
S
--
D
R
---
T
----
Y
L
A
E
N
-
V
D
C
A
I
R
---
A
G
T
L
T
----
D
Q
S
L
I
A
R
R
I
-
T
E
M
K
F
-
V
A
C
A
S
R
D
F
L
E
R
H
-
P
V
P
Q
-
H
P
S
D
L
-
E
K
N
C
-
Y
V
V
G
Y
F
L
P
K
-
Q
Q
M
P
F
-
H
F
R
R
G
-
N
E
E
I
E
V
-
S
G
R
Y
T
M
-
A
A
N
E
S
T
T
-
Y
-
L
A
A
-
A
R
--
A
-
G
L
G
V
I
Q
A
P
L
F
M
-
V
R
E
--
D
L
R
N
G
T
-
M
V
P
-
V
L
P
D
-
W
Q
-
V
-
E
P
M
P
--
I
Y
L
V
Y
P
P
N
R
H
L
S
S
R
L
-
R
V
F
A
D
W
V
V
K
V
M
A
Q
S
Q
N
------------
44
HHSearch
66.99
24%
-125
* C1 *
3HHF
1
?
B:
[5-208]
-----------------------------------------------------------------------------------------------
P
Q
G
-
V
L
S
V
D
S
A
-
M
-
P
M
V
L
H
L
L
A
P
L
A
A
K
F
N
E
R
Y
P
H
I
-
R
L
S
L
V
---
S
S
--
E
G
---
Y
I
N
--
L
I
E
R
K
-
V
D
I
A
L
R
---
A
G
--
D
----
D
S
G
L
R
A
R
H
L
-
F
D
S
R
F
-
R
V
I
A
S
P
E
Y
L
A
K
H
-
G
T
P
Q
-
S
T
E
E
L
-
A
G
H
Q
-
C
L
G
F
T
E
P
G
S
--
L
N
T
W
-
A
V
L
D
A
Q
G
--
N
P
Y
-
K
I
S
P
H
F
-
T
A
S
S
G
E
I
-
L
-
R
S
L
-
C
L
--
S
-
G
C
G
I
V
C
L
S
D
F
L
-
V
D
N
--
D
I
A
E
G
K
-
L
I
P
-
L
L
A
E
-
Q
T
S
D
-
K
T
H
P
--
F
N
A
V
Y
Y
S
D
K
A
V
N
L
R
L
-
R
V
F
L
D
F
L
V
E
E
L
G
----------------
28
HHSearch
66.32
14%
-98
- C1 -
3FXQ
7
TSAR_COMTE
A:
[1-296]
----
M
L
K
L
Q
T
L
Q
A
L
I
C
I
E
E
V
G
S
L
R
A
A
A
Q
L
L
H
L
S
Q
P
A
L
S
A
A
I
Q
Q
L
E
D
E
L
K
A
P
L
L
V
R
T
K
R
G
V
S
L
T
S
F
G
Q
A
F
M
K
H
A
R
L
I
V
T
-
E
S
R
R
A
Q
E
E
I
G
Q
L
R
-
G
R
W
E
G
-
H
I
T
F
A
A
S
-
P
-
A
I
A
L
A
A
L
P
L
A
L
A
S
F
A
R
E
F
P
D
V
-
T
V
N
V
R
---
D
G
--
M
Y
PAV
S
P
Q
--
L
R
D
G
T
-
L
D
F
A
L
T
---
A
A
H
K
H
D
I
--
D
T
D
L
E
A
Q
P
L
-
Y
V
S
D
V
-
V
I
V
G
Q
R
Q
H
P
M
A
N
---
A
T
-
R
L
A
E
L
-
Q
E
C
R
-
W
A
F
S
S
A
P
R
G
---
P
G
A
-
I
I
R
N
A
F
-
A
R
Y
G
L
P
E
P
K
L
G
L
-
V
C
E
S
F
L
A
-
L
-
P
G
V
-
V
A
--
H
-
S
D
L
L
T
T
M
P
R
T
L
-
Y
E
R
--
N
A
F
K
D
Q
-
L
C
S
-
I
P
L
Q
-
D
A
-
L
-
P
N
P
T
--
I
Y
V
L
R
R
H
D
L
P
V
T
P
A
A
-
A
G
L
I
R
W
I
Q
H
H
A
L
----------------
5
PsiBlast_PDB
66.27
25%
-125
- C1 -
3HHF
1
?
B:
[5-205]
-----------------------------------------------------------------------------------------------
P
Q
G
-
V
L
S
V
D
S
A
-
M
-
P
M
V
L
H
L
L
A
P
L
A
A
K
F
N
E
R
Y
P
H
I
-
R
L
S
L
V
---
S
S
--
E
G
---
Y
I
N
--
L
I
E
R
K
-
V
D
I
A
L
R
---
A
G
----
D
--
D
S
G
L
R
A
R
H
L
-
F
D
S
R
F
-
R
V
I
A
S
P
E
Y
L
A
K
H
-
G
T
P
Q
-
S
T
E
E
L
-
A
G
H
Q
-
C
L
G
F
T
E
P
--
G
S
L
N
T
W
-
A
V
L
D
A
Q
G
N
--
P
Y
-
K
I
S
P
H
F
-
T
A
S
S
G
E
I
-
L
-
R
S
L
-
C
L
--
S
-
G
C
G
I
V
C
L
S
D
F
L
-
V
D
N
--
D
I
A
E
G
K
-
L
I
P
-
L
L
A
E
-
Q
T
-
S
-
D
K
T
H
P
F
N
A
V
Y
Y
-
S
D
K
A
V
N
L
R
L
-
R
V
F
L
D
F
L
V
E
E
L
G
----------------
48
Fugue
65.60
24%
-118
- C1 -
3HHF
1
?
A:
[5-207]
-----------------------------------------------------------------------------------------------
P
Q
G
-
V
L
S
V
D
S
A
M
P
M
V
L
H
L
--
L
A
P
L
A
A
K
F
N
E
R
Y
P
H
I
-
R
L
S
L
V
---
S
S
--
E
G
---
Y
I
N
--
L
I
E
R
K
-
V
D
I
A
L
R
---
A
G
E
-
L
-
D
--
D
S
G
L
R
A
R
H
L
-
F
D
S
R
F
-
R
V
I
A
S
P
E
Y
L
A
K
H
-
G
T
P
Q
-
S
T
E
E
L
-
A
G
H
Q
-
C
L
G
F
T
E
P
G
S
L
N
--
T
W
-
A
V
L
D
A
Q
G
N
--
P
Y
-
K
I
S
P
H
F
-
T
A
S
S
G
E
I
-
L
-
R
S
L
-
C
L
--
S
-
G
C
G
I
V
C
L
S
D
F
L
-
V
D
N
--
D
I
A
E
G
K
-
L
I
P
-
L
L
A
E
-
Q
T
-
S
D
K
T
H
P
--
F
N
A
V
Y
Y
S
D
K
A
V
N
L
R
L
-
R
V
F
L
D
F
L
V
E
E
L
G
----------------
52
Fugue
64.66
20%
-92
- C1 -
3FZV
1
?
A:
[4-300]
-----
Y
T
L
R
Q
L
K
Y
F
V
T
T
V
E
C
G
S
V
A
E
A
S
R
K
L
Y
I
A
Q
-
S
I
S
T
A
V
K
G
L
E
E
S
F
V
---------
Q
L
F
L
T
P
A
G
A
R
F
Y
R
K
A
Q
E
L
L
R
M
A
H
E
F
E
Q
N
L
A
D
N
---
D
V
I
A
G
-
Q
I
D
I
G
C
F
-
E
-
T
V
A
P
L
Y
L
P
G
L
I
A
G
F
R
Q
A
Y
P
G
V
E
I
R
I
R
D
---
G
E
--
Q
Q
---
E
L
V
Q
G
L
T
S
G
R
-
F
D
L
A
F
L
---
Y
E
H
-
D
-
L
--
D
S
T
I
E
T
E
P
L
M
P
P
Q
R
P
-
H
A
L
L
P
E
G
H
R
F
A
G
-
Q
A
Q
V
-
S
L
R
D
L
-
C
L
E
P
M
I
L
L
D
V
Q
P
S
R
T
Y
F
V
S
L
-
F
E
E
L
---------
G
L
T
P
N
I
-
A
F
S
S
P
S
I
-
E
M
V
R
G
M
V
G
--
Q
-
G
F
G
F
S
L
L
V
T
R
P
-
H
S
E
--
C
T
Y
D
G
K
-
K
V
V
M
V
D
L
A
-
E
P
-
V
-
S
T
S
G
--
L
A
A
A
W
L
K
R
A
Q
L
T
K
P
A
-
R
L
F
V
D
Y
C
R
E
Q
L
G
K
---------------
54
Fugue
63.25
15%
-83
- C1 -
2ESN
-
?
A:
[3-303]
PLLR
R
L
D
L
N
L
L
L
V
F
D
A
L
Y
R
H
R
N
V
G
T
A
A
S
E
L
A
I
S
A
S
A
F
S
H
A
L
G
R
L
R
Q
G
L
D
D
E
L
F
L
R
Q
G
N
R
M
Q
P
T
Q
R
A
E
H
L
A
A
A
V
A
A
A
L
R
-
A
L
G
E
G
L
E
E
W
R
P
F
V
-
P
G
Q
S
Q
R
T
F
V
F
A
A
T
-
D
-
Y
T
A
F
A
L
L
P
P
L
M
N
R
L
Q
H
S
A
P
G
V
-
R
L
R
L
V
NAE
R
K
--
L
S
---
V
E
A
--
L
A
S
G
R
-
I
D
F
A
L
G
Y
D
E
E
H
E
-
R
-
L
--
P
E
G
I
Q
A
H
D
W
-
F
A
D
R
Y
-
V
V
V
A
R
R
D
H
P
R
L
A
-
G
A
P
T
--
L
E
G
Y
-
L
A
E
R
-
H
A
V
V
T
P
W
N
E
D
S
G
V
I
D
-
R
L
L
A
R
S
G
L
R
R
E
V
-
A
V
Q
L
P
T
-----------------------------
V
L
A
-
A
L
F
--
L
A
G
S
T
D
-
F
L
L
-
T
A
P
R
-
H
A
-
A
-
R
A
L
A
--
E
A
A
G
L
A
L
Y
P
A
-
P
F
D
I
-
P
P
Y
V
L
R
L
Y
S
H
V
Q
G
R
D
A
H
A
W
M
I
G
Q
L
K
G
LD
37
HHSearch
62.06
18%
-71
- C1 -
3ISP
-
Y1985_MYCTU
A:
[5-296]
----
Q
L
D
G
P
Q
L
A
A
L
A
A
V
V
E
L
G
S
F
D
A
A
A
E
R
L
H
V
T
P
S
A
V
S
Q
R
I
K
S
L
E
Q
Q
V
G
Q
V
L
V
V
R
E
-
K
P
C
R
A
T
T
A
G
I
P
L
L
R
L
A
A
Q
T
A
L
-
L
E
S
E
A
L
A
E
M
G
--
A
-
S
L
K
R
T
-
R
I
T
I
A
V
N
-
A
-
D
S
M
A
T
W
F
S
A
V
F
D
G
----
L
G
D
V
-
L
L
D
V
R
---
I
E
--
D
Q
D
H
S
A
R
L
--
L
R
E
G
V
-
A
M
G
A
V
T
---
T
E
R
N
P
----
V
P
G
C
R
V
H
P
L
-
G
E
M
R
Y
-
L
P
V
A
S
R
P
F
V
Q
R
H
L
S
D
G
F
-
T
A
A
A
A
-
A
K
A
P
-
S
L
A
W
N
R
D
-
D
-
G
L
Q
D
M
-
L
V
R
K
A
F
-
R
R
A
I
---
T
R
P
T
H
-
F
V
P
T
T
E
G
-
F
-
T
A
A
-
A
R
--
A
-
G
L
G
W
G
M
F
P
E
K
L
-
A
A
S
--
P
L
A
D
G
S
-
F
V
R
-
V
C
D
I
-------
H
L
D
--
V
P
L
Y
W
Q
C
W
K
L
D
S
P
I
I
-
A
R
I
T
D
T
V
R
A
A
A
S
G
L
Y
R
G
Q
----------
53
Fugue
62.04
22%
-96
- C1 -
3KOS
9
AMPR_CITFR
A:
[11-210]
------------------------------------------------------------------------------------------------
Q
E
-
K
L
K
I
G
V
V
-
G
-
T
F
A
I
G
C
L
F
P
L
L
S
D
F
K
R
S
Y
P
H
I
-
D
L
H
I
S
---
T
H
--
N
N
---
R
V
D
--
P
A
A
E
G
-
L
D
Y
T
I
R
---
Y
G
G
-
G
-
A
--
W
H
D
T
D
A
Q
Y
L
-
C
S
-
A
L
M
S
P
L
C
S
P
T
L
A
S
----
Q
I
Q
-
T
P
A
D
I
-
L
K
F
P
---
L
L
R
S
Y
R
R
D
E
W
A
L
W
M
Q
----
T
V
G
E
A
P
P
-
S
P
T
H
N
V
M
V
F
D
S
S
V
T
M
L
-
E
A
A
-
Q
A
--
G
M
G
V
A
I
---
A
P
V
R
M
F
T
H
--
L
L
S
S
E
R
-
I
V
Q
-
P
F
L
---
T
-
Q
-
I
D
L
G
--
S
Y
W
I
T
R
L
Q
S
R
P
E
T
P
A
M
R
E
F
S
R
W
L
T
G
V
L
H
K
T
--------------
31
HHSearch
59.98
14%
-87
- C1 -
2ESN
-
?
A:
[7-303]
----
R
L
D
L
N
L
L
L
V
F
D
A
L
Y
R
H
R
N
V
G
T
A
A
S
E
L
A
I
S
A
S
A
F
S
H
A
L
G
R
L
R
Q
G
L
D
D
E
L
F
L
R
Q
G
N
R
M
Q
P
T
Q
R
A
E
H
L
A
A
A
V
A
A
A
L
R
-
A
L
G
E
G
L
E
E
W
R
P
F
V
P
G
Q
S
Q
R
-
T
F
V
F
A
A
T
-
D
-
Y
T
A
F
A
L
L
P
P
L
M
N
R
L
Q
H
S
A
P
G
V
-
R
L
R
L
V
---
N
A
--
E
R
KLS
V
E
A
--
L
A
S
G
R
-
I
D
F
A
L
G
---
Y
D
E
E
H
-
E
RL
P
E
G
I
Q
A
H
D
W
-
F
A
D
R
Y
-
V
V
V
A
R
R
D
H
P
R
L
A
-
G
-
A
P
-
T
L
E
G
Y
-
L
A
E
R
-
H
A
V
V
T
P
W
-
N
E
-
D
S
-
G
-
V
I
D
R
L
L
-
A
R
S
G
L
-
R
R
E
V
A
V
-
Q
L
P
T
V
L
A
-
A
-
L
F
L
-
A
G
--
S
-
T
D
F
L
L
T
A
P
R
H
A
-
A
R
A
--
L
A
E
A
A
G
-
L
A
L
-
Y
P
A
P
-
F
D
-
I
-
P
P
Y
V
--
L
R
L
Y
S
H
V
Q
--
G
R
D
A
H
-
A
W
M
I
G
Q
L
K
G
L
D
-----------------
43
HHSearch
58.94
19%
-84
- C1 -
2FYI
-
CBL_ECOLI
A:
[89-299]
---------------------------------------------------------------------------------------------
N
D
T
S
G
-
V
L
T
I
A
T
T
-
H
-
T
Q
A
R
Y
S
L
P
E
V
I
K
A
F
R
E
L
F
P
E
V
-
R
L
E
L
I
---
Q
G
--
T
P
Q
E
I
A
T
L
--
L
Q
N
G
E
-
A
D
I
G
I
A
---
S
E
R
L
S
-
N
--
D
P
Q
L
V
A
F
P
W
-
F
R
W
H
H
-
S
L
L
V
P
H
D
H
P
L
T
Q
-
I
S
P
L
-
T
L
E
S
I
-
A
K
W
P
-
L
I
T
Y
R
Q
G
-
I
-
T
G
R
S
R
--
I
D
D
A
F
-
A
R
K
G
L
-
L
A
D
I
V
L
-
S
A
Q
D
S
D
V
-
I
-
K
T
Y
-
V
A
--
L
-
G
L
G
I
G
L
V
A
E
Q
S
-
S
G
E
--
Q
-
E
E
E
N
-
L
I
R
-
L
D
T
R
-
H
L
-
F
-
D
A
N
T
--
V
W
L
G
L
K
R
G
Q
L
Q
R
N
Y
V
-
W
R
F
L
E
L
C
N
A
G
L
S
V
E
D
I
K
R
Q
V
M
E
S
-----
47
HHSearch
53.58
18%
-95
- C1 -
2QL3
-
?
A:
[3-207]
-----------------------------------------------------------------------------------------------
V
A
G
-
P
I
A
V
G
C
Y
-
P
-
A
L
G
P
T
I
L
P
S
M
L
Y
A
F
T
A
E
Y
P
R
A
-
S
V
E
F
R
---
E
D
--
T
Q
N
R
L
R
T
Q
--
L
E
G
G
E
-
L
D
V
A
I
V
---
Y
D
L
D
L
----
S
P
E
W
Q
T
V
P
L
-
M
T
R
E
P
-
M
V
V
L
G
A
E
H
P
L
A
G
V
D
G
P
V
-
R
L
A
D
L
-
A
E
H
P
-
M
V
L
L
D
A
P
P
---
S
T
N
H
--
A
M
D
V
C
-
R
E
A
G
F
-
A
P
R
V
A
Y
-
R
T
A
N
F
E
T
-
A
-
R
A
F
-
V
G
--
R
-
G
L
G
W
T
L
L
L
Q
R
P
-
R
V
D
--
V
T
Y
E
G
L
P
V
V
V
-
K
P
I
A
E
P
K
-
P
-
A
S
V
A
--
V
V
V
A
W
H
Q
E
A
T
L
S
R
V
A
-
R
A
F
I
R
F
V
T
A
-------------------