@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0184: (2015-12-25 )
MNAFTAPATGTPLVSFRQVRKHFAVDGRRLEAIQQFDLEIGEGEFIAIVGASGCGKSTLLRLLIGLDRDYDGEIRVDGRPIAGIGGERGIVFQEHRLFPWLTVQQNVALGLVNEALGETDKAARIDEYIRLVGLHGFERAYPHQLSGGMAQRVAIARGLVASPRLLLLDEPFSALDALTRQQLQEELLAIRRRTRITTLLVTHDVEEALYLADRVVVMEPRPGRIRRVVEVGLAHPRERGGFDFLRQREALLHELTADGEYVAPPPRRVENLPFEFIAC
Atome Classification :
(20 SA)
.........10........20........30........40........50........60........-----70.......------.--------80..--------...-----..---------.90........100.......110..---.....120....-...130....-...140.......150.......160.......170.......180.......190---.......200...------....210.......220......--.230...--....240.....--------------------..250.-----......260.......270.......-----------------------------------------------------------------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MNAFTAPATGT
P
L
V
S
F
R
Q
V
R
K
H
FAVD
G
R
R
L
E
A
I
Q
Q
FDLEIGEG
E
F
I
A
I
V
GASGC
G
K
S
T
L
L
R
L
L
I
GLDRD-----YDG
E
I
R
VDG------
R
--------
P
IAG--------IGG-----ER---------
G
I
V
F
QEHRL
F
P
W
L
T
VQQ
N
V
A
L
G
L
V
N
E
---
A
LGET
D
K
A
A
R
I
D
-
E
Y
I
R
L
V
GLHG-
F
E
R
AY
P
H
QLSG
G
M
A
Q
R
V
A
I
A
RGLVAS
P
R
L
L
L
LDE
P
F
S
A
L
D
A
L
T
R
Q
Q
L
Q
E
E
L
L
A
I
R
R
---RT
R
I
T
T
L
L
V
TH
D
V
------
E
E
A
L
Y
LA
D
R
V
V
V
MEPRP
G
R
I
R
R
V
--
V
E
V
GLAH--PRERG
G
F
D
F
L
R
Q
--------------------
R
E
A
L
L
H
-----
E
LTADGEYVAPP
P
R
R
V
ENL
P
F
E
F
IAC-----------------------------------------------------------------------------
136
Fugue
88.23
31%
-115
- C1 -
1Z47
1
?
A:
[11-355]
---------
G
S
M
T
I
E
F
V
G
V
E
K
I
Y
---
P
G
G
A
R
S
V
R
G
V
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
-----
T
K
G
D
V
W
I
G
G
------
K
--------
R
V
T
D
--------
L
P
P
-----
Q
K
RN
V
------
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
L
R
E
K
---
R
V
P
K
D
E
M
D
A
R
V
R
-
E
L
L
R
F
M
R
L
E
S
-
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
---
E
M
G
V
T
S
V
F
V
T
H
D
Q
------
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
--
G
N
V
E
Q
F
--
G
T
P
E
E
V
Y
EK
P
G
T
L
F
V
A
S
F
I
G
E
--------------------
S
N
V
W
T
R
A
V
Q
NG
R
I
E
V
A
G
A
A
L
P
V
D
P
A
V
S
E
G
S
E
V
A
V
V
V
R
PKD
V
E
L
Q
P
A
S
EREAHAQVV
R
S
A
F
KGS
Y
S
A
C
W
I
R
T
KD
G
E
V
W
E
V
H
V
P
SADRHRWSPG
A
W
V
H
M
N
V
T
R
W
F
I
F
P
R-------
135
Fugue
80.11
31%
-104
- C1 -
3TUZ
3
METN_ECOLI
H:
[23-362]
-----------
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
-----
T
E
G
S
V
L
V
D
G
------
Q
ELTTLSES
E
L
T
K
--------
A
R
R
-----
Q
I
---------
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
---
N
T
P
K
D
E
V
K
R
R
V
T
-
E
L
L
S
L
V
G
L
G
D
-
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
---
R
L
G
L
T
I
L
L
I
T
H
E
M
------
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
--
V
S
E
V
F
S
H
--
P
K
T
P
L
A
Q
K
F
I
Q
S
TLHLDIPEDYQERLQAEPFT
D
C
V
P
M
L
-----
R
L
E
F
T
G
Q
S
V
D
A
P
L
L
S
E
T
A
R
R
F
N
V
N
N
N
IISAQMDYAGGVKFGIMLTEMHGTQQDTQAAIAWLQEHHVKVEV---------------------------------
52
PsiBlast_CBE
78.61
33%
-126
* C1 *
3TUZ
1
METN_ECOLI
C:
[24-256]
------------
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
-----
T
E
G
S
V
L
V
D
G
------
Q
--------
E
L
T
T
--------
L
S
E
-----
S
E
LTKARRQI-
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
---
N
T
P
K
D
E
V
K
R
R
V
T
-
E
L
L
S
L
V
G
L
G
D
-
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
---
R
L
G
L
T
I
L
L
I
T
H
E
M
------
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
--
V
S
E
V
F
S
H
--
P
K
T
P
L
A
Q
K
F
I
Q
S
--------------------
T
L
H
L
D
I
-----
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
F
T
G
-----------------------------------------------------------------------------
56
PsiBlast_CBE
77.59
33%
-123
- C1 -
3TUI
1
METN_ECOLI
C:
[24-256]
------------
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
-----
T
E
G
S
V
L
V
D
G
------
Q
--------
E
L
T
T
--------
L
S
E
-----
S
E
LTKARRQI-
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
---
N
T
P
K
D
E
V
K
R
R
V
T
-
E
L
L
S
L
V
G
L
G
D
-
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
---
R
L
G
L
T
I
L
L
I
T
H
E
M
------
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
--
V
S
E
V
F
S
H
--
P
K
T
P
L
A
Q
K
F
I
Q
S
--------------------
T
L
H
L
D
I
-----
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
F
T
G
-----------------------------------------------------------------------------
133
Fugue
77.51
32%
-106
- C1 -
1OXS
23
?
C:
[1-352]
----------
M
V
R
I
I
V
K
N
V
S
K
V
F
--
K
K
G
K
V
V
A
L
D
N
V
N
I
N
I
E
N
G
E
R
F
G
I
L
G
P
S
G
A
G
K
T
T
F
M
R
I
I
A
G
L
D
V
P
-----
S
T
G
E
L
Y
F
D
D
------
R
--------
L
V
A
S
--------
N
G
K
-----
L
I
VPPEDRKI-
G
M
V
F
Q
T
W
A
L
Y
P
N
L
T
A
F
E
N
I
A
F
P
L
T
N
M
---
K
M
S
K
E
E
I
R
K
R
V
E
-
E
V
A
K
I
L
D
I
H
H
-
V
L
N
H
F
P
R
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
V
K
D
P
S
L
L
L
L
D
E
P
F
S
N
L
D
A
R
M
R
D
S
A
R
A
L
V
K
E
V
Q
S
---
R
L
G
V
T
L
L
V
V
S
H
D
P
------
A
D
I
F
A
I
A
D
R
V
G
V
L
V
K
--
G
K
L
V
Q
V
GK
P
E
D
L
Y
D
N
--
P
V
S
I
Q
V
A
S
L
I
G
E
--------------------
I
N
E
L
E
G
-----
K
V
T
N
E
G
V
V
I
G
S
L
R
F
P
V
S
V
S
S
D
R
A
I
I
G
IRPEDVKLSKDVIKDDSWILVGKGKVKVIGYQGGLFRITITPLDSEEEIFTYSDHPIHSGEEVLVYVRKDKIKVFEK
55
PsiBlast_CBE
77.03
33%
-118
- C1 -
3TUI
1
METN_ECOLI
D:
[24-256]
------------
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
-----
T
E
G
S
V
L
V
D
G
------
Q
--------
E
L
T
T
--------
L
S
E
-----
S
E
LTKARRQI-
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
---
N
T
P
K
D
E
V
K
R
R
V
T
-
E
L
L
S
L
V
G
L
G
D
-
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
---
R
L
G
L
T
I
L
L
I
T
H
E
M
------
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
--
V
S
E
V
F
S
H
--
P
K
T
P
L
A
Q
K
F
I
Q
S
--------------------
T
L
H
L
D
I
-----
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
F
T
G
-----------------------------------------------------------------------------
54
PsiBlast_CBE
75.89
33%
-116
- C1 -
3TUI
1
METN_ECOLI
G:
[24-256]
------------
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
-----
T
E
G
S
V
L
V
D
G
------
Q
--------
E
L
T
T
--------
L
S
E
-----
S
E
LTKARRQI-
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
---
N
T
P
K
D
E
V
K
R
R
V
T
-
E
L
L
S
L
V
G
L
G
D
-
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
---
R
L
G
L
T
I
L
L
I
T
H
E
M
------
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
--
V
S
E
V
F
S
H
--
P
K
T
P
L
A
Q
K
F
I
Q
S
--------------------
T
L
H
L
D
I
-----
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
F
T
G
-----------------------------------------------------------------------------
61
PsiBlast_CBE
75.74
38%
-116
- C1 -
4U00
3
?
A:
[3-212]
-----------
P
I
I
R
I
R
N
L
H
K
W
F
G
P
----
L
H
V
L
K
G
I
H
L
E
V
A
P
G
E
K
L
V
I
I
G
P
S
G
S
G
K
S
T
L
I
R
T
I
N
R
L
E
D
F
-----
Q
E
G
E
V
V
V
D
G
LSVKDD
R
--------
A
L
R
E
--------
I
R
R
-----
E
V
---------
G
M
V
F
Q
Q
F
N
L
F
P
H
M
T
V
L
E
N
V
T
L
A
P
M
R
V
---
R
R
W
P
R
E
K
A
E
K
K
A
L
E
L
L
E
R
V
G
I
L
D
-
Q
A
R
K
Y
P
A
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
M
E
P
K
I
M
L
F
D
E
P
T
S
A
L
D
P
----
E
M
V
G
E
V
L
D
V
M
R
D
L
A
Q
G
G
M
T
M
V
V
V
T
H
E
M
------
G
F
A
R
E
V
A
D
R
V
V
F
M
D
G
G
Q
I
V
E
E
G
R
--
P
E
E
I
F
T
R
--
P
K
E
E
R
T
R
S
F
L
Q
R
--------------------
V
L
H
---------------------------------------------------------------------------------------------------------------
119
HHSearch
75.54
35%
-125
- C1 -
3TUI
1
METN_ECOLI
C:
[23-249]
-----------
H
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
-----
T
E
G
S
V
L
V
D
G
------
Q
--------
E
L
T
T
LSESELTK
A
R
R
-----
Q
I
---------
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
---
N
T
P
K
D
E
V
K
R
R
V
T
-
E
L
L
S
L
V
G
L
G
D
-
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
---
R
L
G
L
T
I
L
L
I
T
H
E
M
------
D
V
V
K
R
I
C
D
C
V
A
V
I
S
--
N
G
E
L
I
E
Q
--
D
T
V
S
E
V
F
--
S
H
P
K
T
P
L
A
Q
K
F
I
--------------------
Q
S
T
L
H
L
-----
D
I
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
F
-----------------------------------------------------------------------------
6
PsiBlast_PDB
75.06
41%
-122
- C1 -
3FVQ
3
FBPC_NEIG1
A:
[9-217]
---------------------
H
L
S
K
S
F
Q
N
T
P
V
L
N
D
I
S
L
S
L
D
P
G
E
I
L
F
I
I
G
A
S
G
C
G
K
T
T
L
L
R
C
L
A
G
F
E
Q
P
-----
D
S
G
E
I
S
L
S
G
------
K
--------
T
I
F
S
--------
K
N
T
N
L
P
VR
E
R
R
L
-------
G
Y
L
V
Q
E
G
V
L
F
P
H
L
T
V
Y
R
N
I
A
Y
G
L
G
N
G
---
K
G
R
T
A
Q
E
R
Q
R
I
E
-
A
M
L
E
L
T
G
I
S
E
-
L
A
G
R
Y
P
H
E
L
S
G
G
Q
Q
Q
R
A
A
L
A
R
A
L
A
P
D
P
E
L
I
L
L
D
E
P
F
S
A
L
D
E
Q
L
R
R
Q
I
R
E
D
M
I
A
A
L
R
---
A
N
G
K
S
A
V
F
V
S
H
D
R
------
E
E
A
L
Q
Y
A
D
R
I
A
V
M
--
K
Q
G
R
I
L
Q
T
--
A
S
P
H
E
L
Y
--
R
Q
P
A
D
L
D
A
A
L
F
I
--------------------
G
E
G
I
V
F
-----
P
A
A
L
N
A
D
G
T
A
D
C
R
L
G
R
L
P
V
Q
S
G
A
P
A
G
-----------------------------------------------------------------------------
115
HHSearch
75.04
38%
-119
- C1 -
2IT1
-
?
A:
[3-219]
------------
E
I
K
L
E
N
I
V
K
K
F
G
----
N
F
T
A
L
N
N
I
N
L
K
I
K
D
G
E
F
M
A
L
L
G
P
S
G
S
G
K
S
T
L
L
Y
T
I
A
G
I
Y
K
P
-----
T
S
G
K
I
Y
F
D
E
------
K
--------
D
V
T
E
LPP-----
K
D
R
-----
N
V
---------
G
L
V
F
Q
N
W
A
L
Y
P
H
M
T
V
Y
K
N
I
A
F
P
L
E
L
R
---
K
A
P
R
E
E
I
D
K
K
V
R
-
E
V
A
K
M
L
H
I
D
K
-
L
L
N
R
Y
P
W
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
V
K
E
P
E
V
L
L
L
D
E
P
L
S
N
L
D
A
L
L
R
L
E
V
R
A
E
L
K
R
L
Q
K
---
E
L
G
I
T
T
V
Y
V
T
H
D
Q
------
A
E
A
L
A
M
A
D
R
I
A
V
I
R
--
E
G
E
I
L
Q
V
--
G
T
P
D
E
V
Y
--
Y
K
P
K
Y
K
F
V
G
G
F
L
--------------------
G
N
P
P
M
N
-----
F
V
E
A
K
V
E
D
G
K
L
V
I
T
E
K
S
K
L
P
I
P
K
Q
Y
V
-----------------------------------------------------------------------------
53
PsiBlast_CBE
74.81
33%
-121
- C1 -
3TUI
1
METN_ECOLI
H:
[24-256]
------------
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
-----
T
E
G
S
V
L
V
D
G
------
Q
--------
E
L
T
T
--------
L
S
E
-----
S
E
LTKARRQI-
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
---
N
T
P
K
D
E
V
K
R
R
V
T
-
E
L
L
S
L
V
G
L
G
D
-
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
---
R
L
G
L
T
I
L
L
I
T
H
E
M
------
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
--
V
S
E
V
F
S
H
--
P
K
T
P
L
A
Q
K
F
I
Q
S
--------------------
T
L
H
L
D
I
-----
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
F
T
G
-----------------------------------------------------------------------------
82
PsiBlast_CBE
74.74
33%
-123
- C1 -
3TIF
7
Y796_METJA
B:
[1-220]
------------
M
V
K
L
K
N
V
T
K
T
Y
K
M
G
E
E
I
I
Y
A
L
K
N
V
N
L
N
I
K
E
G
E
F
V
S
I
M
G
P
S
G
S
G
K
S
T
M
L
N
I
I
G
C
L
D
K
P
-----
T
E
G
E
V
Y
I
D
N
------
I
--------
K
T
N
D
--------
L
D
D
-----
D
E
LTKIRRDKI
G
F
V
F
Q
Q
F
N
L
I
P
L
L
T
A
L
E
N
V
E
L
P
L
I
F
K
YRG
A
M
S
G
E
E
R
R
K
R
A
L
-
E
C
L
K
M
A
E
L
E
E
R
F
A
N
H
K
P
N
Q
L
S
G
G
Q
Q
Q
R
V
A
I
A
R
A
L
A
N
N
P
P
I
I
L
A
D
Q
P
T
W
A
L
D
S
K
T
G
E
K
I
M
Q
L
L
K
K
L
N
E
---
E
D
G
K
T
V
V
V
V
T
H
D
I
NVARFG
E
R
I
I
Y
L
K
D
G
E
V
E
R
E
E
K
L
R
G
F
----------------------------------------------------------------------------------------------------------------------------------------------------------------
51
PsiBlast_CBE
74.46
33%
-119
- C1 -
3TUZ
1
METN_ECOLI
D:
[24-256]
------------
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
-----
T
E
G
S
V
L
V
D
G
------
Q
--------
E
L
T
T
--------
L
S
E
-----
S
E
LTKARRQI-
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
---
N
T
P
K
D
E
V
K
R
R
V
T
-
E
L
L
S
L
V
G
L
G
D
-
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
---
R
L
G
L
T
I
L
L
I
T
H
E
M
------
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
--
V
S
E
V
F
S
H
--
P
K
T
P
L
A
Q
K
F
I
Q
S
--------------------
T
L
H
L
D
I
-----
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
F
T
G
-----------------------------------------------------------------------------
3
PsiBlast_PDB
74.36
37%
-129
- C1 -
4TQU
-
?
S:
[5-216]
-------------
V
S
I
Q
N
V
V
K
R
Y
----
D
K
T
T
V
V
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
I
-----
S
G
G
T
I
R
I
D
G
------
R
--------
V
I
N
D
--------
L
A
P
-----
K
D
RDV------
A
M
V
F
Q
N
Y
A
L
Y
P
H
L
N
V
R
D
N
I
S
F
G
L
R
L
K
---
R
T
K
K
S
V
I
D
A
A
V
K
-
T
A
A
D
I
L
G
L
Q
P
-
L
L
E
R
K
P
S
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
T
Q
M
R
A
E
I
K
R
L
H
Q
---
R
L
G
T
T
V
I
Y
V
T
H
D
Q
------
V
E
A
M
T
L
A
D
R
I
V
V
M
--
R
D
G
L
I
E
Q
I
--
G
K
P
M
D
L
F
--
L
H
P
A
N
T
F
V
A
S
F
I
--------------------
G
S
P
P
M
N
-----
L
M
P
A
R
I
A
V
D
S
T
Q
H
V
E
L
N
G
G
N
R
I
S
L
L
P
-----------------------------------------------------------------------------
1
PsiBlast_PDB
74.27
36%
-123
- C1 -
1Z47
1
?
A:
[11-219]
---------
G
S
M
T
I
E
F
V
G
V
E
K
I
Y
P
G
G
A
R
S
V
R
G
V
---
S
F
Q
I
R
E
G
E
M
V
G
L
L
G
P
S
G
S
G
K
T
T
I
L
R
L
I
A
G
L
E
R
P
-----
T
K
G
D
V
W
I
G
G
------
K
--------
R
V
T
D
--------
L
P
P
-----
Q
K
RN
V
------
G
L
V
F
Q
N
Y
A
L
F
Q
H
M
T
V
Y
D
N
V
S
F
G
L
R
E
K
---
R
V
P
K
D
E
M
D
A
R
V
R
-
E
L
L
R
F
M
R
L
E
S
-
Y
A
N
R
F
P
H
E
L
S
G
G
Q
Q
Q
R
V
A
L
A
R
A
L
A
P
R
P
Q
V
L
L
F
D
E
P
F
A
A
I
D
T
Q
I
R
R
E
L
R
T
F
V
R
Q
V
H
D
---
E
M
G
V
T
S
V
F
V
T
H
D
Q
------
E
E
A
L
E
V
A
D
R
V
L
V
L
H
E
G
N
V
E
Q
F
G
T
--
P
E
E
V
Y
E
K
--
P
G
T
L
F
V
A
S
F
I
G
E
--------------------
S
N
V
W
T
R
-----
A
V
Q
N
G
R
I
E
V
A
G
A
A
L
P
V
D
P
A
V
S
E
G
S
E
V
-----------------------------------------------------------------------------
4
PsiBlast_PDB
74.01
37%
-132
- C1 -
4TQV
-
?
C:
[5-216]
-------------
V
S
I
Q
N
V
V
K
R
Y
----
D
K
T
T
V
V
H
G
V
S
L
D
I
E
P
G
E
F
V
V
L
V
G
P
S
G
C
G
K
S
T
T
L
R
M
V
A
G
L
E
E
I
-----
S
G
G
T
I
R
I
D
G
------
R
--------
V
I
N
D
--------
L
A
P
-----
K
D
RD
V
------
A
M
V
F
Q
N
Y
A
L
Y
P
H
L
N
V
R
D
N
I
S
F
G
L
R
L
K
---
R
T
K
K
S
V
I
D
A
A
V
K
-
T
A
A
D
I
L
G
L
Q
P
-
L
L
E
R
K
P
S
D
L
S
G
G
Q
R
Q
R
V
A
M
G
R
A
I
V
R
D
P
K
V
F
L
F
D
Q
P
L
S
N
L
D
A
K
L
R
T
Q
M
R
A
E
I
K
R
L
H
Q
---
R
L
G
T
T
V
I
Y
V
T
H
D
Q
------
V
E
A
M
T
L
A
D
R
I
V
V
M
--
R
D
G
L
I
E
Q
I
--
G
K
P
M
D
L
F
--
L
H
P
A
N
T
F
V
A
S
F
I
--------------------
G
S
P
P
M
N
-----
L
M
P
A
R
I
A
V
D
S
T
Q
H
V
E
L
N
G
G
N
R
I
S
L
L
P
-----------------------------------------------------------------------------
49
PsiBlast_CBE
73.65
33%
-120
- C1 -
3TUZ
1
METN_ECOLI
H:
[24-256]
------------
M
I
K
L
S
N
I
T
K
V
F
H
Q
G
T
R
T
I
Q
A
L
N
N
V
S
L
H
V
P
A
G
Q
I
Y
G
V
I
G
A
S
G
A
G
K
S
T
L
I
R
C
V
N
L
L
E
R
P
-----
T
E
G
S
V
L
V
D
G
------
Q
--------
E
L
T
T
--------
L
S
E
-----
S
E
LTKARRQI-
G
M
I
F
Q
H
F
N
L
L
S
S
R
T
V
F
G
N
V
A
L
P
L
E
L
D
---
N
T
P
K
D
E
V
K
R
R
V
T
-
E
L
L
S
L
V
G
L
G
D
-
K
H
D
S
Y
P
S
N
L
S
G
G
Q
K
Q
R
V
A
I
A
R
A
L
A
S
N
P
K
V
L
L
C
D
Q
A
T
S
A
L
D
P
A
T
T
R
S
I
L
E
L
L
K
D
I
N
R
---
R
L
G
L
T
I
L
L
I
T
H
E
M
------
D
V
V
K
R
I
C
D
C
V
A
V
I
S
N
G
E
L
I
E
Q
D
T
--
V
S
E
V
F
S
H
--
P
K
T
P
L
A
Q
K
F
I
Q
S
--------------------
T
L
H
L
D
I
-----
P
E
D
Y
Q
E
R
L
Q
A
E
P
F
T
D
C
V
P
M
L
R
L
E
F
T
G
-----------------------------------------------------------------------------
118
HHSearch
73.51
37%
-120
- C1 -
3RLF
3
MALK_ECOLI
A:
[2-219]
-----------
A
S
V
Q
L
Q
N
V
T
K
A
W
G
----
E
V
V
V
S
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
-----
T
S
G
D
L
F
I
G
E
------
K
--------
R
M
N
D
TPP-----
A
E
R
-----
G
V
---------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
K
L
A
---
G
A
K
K
E
V
I
N
Q
R
V
N
-
Q
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
---
R
L
G
R
T
M
I
Y
V
T
H
D
Q
------
V
E
A
M
T
L
A
D
K
I
V
V
L
D
--
A
G
R
V
A
Q
V
--
G
K
P
L
E
L
Y
--
H
Y
P
A
D
R
F
V
A
G
F
I
--------------------
G
S
P
K
M
N
-----
F
L
P
V
K
V
T
A
T
A
I
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
-----------------------------------------------------------------------------
30
PsiBlast_CBE
73.28
41%
-131
- C1 -
3PUX
5
MALK_ECOLI
B:
[20-215]
---------------------------------
K
D
I
N
L
D
I
H
E
G
E
F
V
V
F
V
G
P
S
G
C
G
K
S
T
L
L
R
M
I
A
G
L
E
T
I
T
S
G
D
L
F
I
G
E
K
R
M
N
D
------
T
--------
P
P
A
E
--------
R
G
-------
V
---------
G
M
V
F
Q
S
Y
A
L
Y
P
H
L
S
V
A
E
N
M
S
F
G
L
K
L
A
---
G
A
K
K
E
V
I
N
Q
R
V
N
-
Q
V
A
E
V
L
Q
L
A
H
-
L
L
D
R
K
P
K
A
L
S
G
G
Q
R
Q
R
V
A
I
G
R
T
L
V
A
E
P
S
V
F
L
L
D
E
P
L
S
N
L
D
A
A
L
R
V
Q
M
R
I
E
I
S
R
L
H
K
---
R
L
G
R
T
M
I
Y
V
T
H
D
Q
------
V
E
A
M
T
L
A
D
K
I
V
V
L
D
--
A
G
R
V
A
Q
V
--
G
K
P
L
E
L
Y
--
H
Y
P
A
D
R
F
V
A
G
F
I
--------------------
G
S
P
K
M
N
-----
F
L
P
V
T
A
T
A
I
D
Q
V
Q
V
E
L
P
M
P
N
R
Q
Q
V
W
L
-----------------------------------------------------------------------------