@TOME V2.3
(Nov 2016)
Ref.
-
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Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0185: (2015-12-25 )
MKNIDKTLSPAWSRPLPRLAPPPSAAFARRLGDGLLPWLLPLGLALLWWVASHRHWMSAQVLPTPELVWQSARELLAGELWSELAISLRRLAWGLLAGVASGAALGAWLGFSPRAERLVFPTFSALAQIPTLAWIPLFMLFFGIGELLKLVVLVKAVVVPVTIHTLVGVRDAQPKLREAAAVLRLPPRLLVWRLILPAALPAFLTGLRLALAQGWTSLLAVELLASSEGIGYLMVQGRQLFMLDIVFVCILIIGLVGVGMDRAIQWLDRRLLHWPQAATGEFRRRPPGRGWQRLQVWLPPLALLLLWQSASSAEWVDPAILASPLEVARATWSGALDGSLPGALFDSLKRTLGGLLLGGGLGFLGGLLLGLWRPAERFFGPTFAALRQVAIFAWVPLLTAWFGLGEPAKLTFVAIAAFFPLLLATQRGIASLPPSLGEAARVLRLGPWRRLLRLVLPGAAPSVFAGLRLALIYAWLGTIGAEYFMPSDGGIGSLMIGAQQLFRMDLIGAGMLLVGLTGALLNALGQRIEARATRWRHA
Atome Classification :
(20 SA)
------------------.........10.-----...-....20....---...---.30.....-----------..-----------.40..-------.....---------.50..-......60-.---------------.......70....-.-.-.----.80..----.....--.90.......----.100-........--------110-.--------.-...--..-----120..--------.--....130......------.140----.--.-----------.----------------------.----------------------...--150..-----.....----..160.....-----------...170.......-180..-.....190..-.....200---.......210...------.---------...220--.....-.-.-------------.230-......-----...----240...------.....250.......260.......270.......280.--......290....---...300.-...----------...310...--....320.......330.......----340........350---------....---....--.360---......-------------------..370-.--------...-.-----.------------------.380..-----....-.-390.....-..400----..--.----------------------....410...--....420--...-....430-----........440...-....---450.....-------..460...------....470--.....-..480.......-------------490.....-----.-------------.500--.-.-.......510.......520..-------.....530......----------------------
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
------------------MK
N
I
D
K
TLSPAW-----SRP-LPRLAPP
P
S
A
---
A
F
A
---
R
R
LGD
G
L
L
-----------
P
W
-----------
L
L
P
L
G
-------
L
A
L
L
W
---------
W
V
A
SH-R
H
W
M
SAQV-L---------------P
T
P
E
L
V
W
Q
S
A
R
E
L
-
L
-
A
-
G
----
E
L
W
S
E
----
L
A
I
S
L
--
R
R
L
A
W
G
L
L
A
G
----
V
AS--G
A
A
L
G
A
WL--------GFS-P--------R-A
E
R
--
L
V-----
F
P
T
F
S
--------
A
--
L
AQIP
T
L
A
W
I
P
L
F
------
M
L
F
F
----
G
--
I
-----------
G
----------------------
E
----------------------
L
L
K
--
L
--
V
V
-----
L
V
K
A
V
----VV
P
-
V
T
I
H
T
L
-----------VGVRDAQ
P
K
L
R
E
A
-
A
A
V
LR-L
P
P
R
L
L
V
W
R
L
-
I
L
P
A
A
L
P
A
---
F
L
T
G
L
R
L
A
L
A
Q
G
W
------
T
---------
S
L
L
A
V
---
E
L
L
AS-S-E-------------G
I
---
G
Y
L
M
VQ-----G
R
Q
----
L
F
-
M
L
D
------
I
V
F
V
C
I
L
I
I
G
L
V
GV
G
M
D
R
A
I
Q
W
L
D
R
R
L
LHWPQAATGEFR--RRPPGRGWQ
R
L
Q
V
---
W
L
P
P
L
A
L
-
L
L
L
----------WQSASSAEW--V
D
P
A
I
L
A
S
P
L
E
V
A
R
A
TWSGALDGS----L
P
-
G
A
L
F
D
S
L
K
R
-----------
T
L
G
G
---
L
L
LG--G
G
L
----
G
F
L
G
G
L
-------------------
L
L
G
LW-
R
--------
P
A
E
-
R
-----F------------------FG
P
T
F
A
-----
A
L
R
Q
-
V
-
A
I
F
A
W
V
P
L
-
L
T
A
W
F----GL--G----------------------EPA
K
L
T
F
V
A
I
--
A
A
F
F
P
L
L
--
L
A
T
-QR
G
I
AS------LPP
S
L
G
E
A
A
R
V
LRL-
G
P
W
R
---
R
L
L
R
L
VLP-------GA
A
P
S
V
F
A
------
G
L
R
L
A
L
I
--
Y
A
W
L
G
-
T
I
G
A
E
Y
FMPSDG-------------G
I
G
S
L
M
I
G
-----
A
-------------
Q
Q
----
L
-
F
-
R
M
D
L
IG
A
G
M
L
L
V
G
L
T
G
A
L
L
N
A
L
-------
G
Q
R
I
E
A
R
A
TRWRHA----------------------
19
Fugue
76.45
16%
-117
* C6 *
4XGC
-
?
C:
[1-676]
------------------
M
Q
P
F
Y
E
E
Y
R
K
A
W
-----
N
Q
I
-
N
D
H
I
A
D
L
Q
H
R
---
S
Y
A
---
R
T
L
E
Q
-
L
V
-----------
D
F
-----------
V
V
G
Q
A
E
RDE
V
L
P
T
A
A
L
L
---------
T
G
I
N
Q
-
P
D
H
L
S
Q
F
T
-
A
---------------
L
T
Q
R
L
H
A
Q
--
R
A
A
-
M
-
V
-
C
----
V
L
Q
S
R
DCAT
L
K
A
A
V
--
E
T
L
V
F
G
L
V
E
D
----
N
A
E
--
V
E
Q
L
R
R
S
Q
--------
C
T
M
-
K
--------
Q
-
L
K
S
--
W
Y
-----
T
N
N
F
D
--------
S
--
E
Q
K
R
R
Q
L
V
V
I
L
P
D
------
F
E
C
F
----
N
--
A
-----------
S
----------------------
V
----------------------
L
Q
D
--
L
--
I
L
-----
I
L
S
A
H
----
C
G
S
-
L
P
F
V
L
V
-----------
L
G
V
A
T
A
M
T
A
V
H
G
T
L
P
Y
H
V
S
-
S
K
I
R
L
R
V
F
Q
T
Q
A
A
P
T
G
L
N
E
---
V
L
D
K
V
L
L
S
P
K
Y
A
F
------
H
L
S
G
K
T
F
---
K
F
L
T
H
---
I
F
L
Y
Y
-
D
-
F
-------------
S
I
---
H
G
F
I
Q
G
-----
F
K
Y
----
C
L
-
M
E
H
------
F
F
G
G
N
A
F
A
L
C
---
T
D
Y
S
K
A
L
G
R
I
K
Q
----
L
T
H
E
D
M
E
T
I
R
--
R
L
P
S
F
R
P
Y
V
E
Q
I
N
---
D
C
K
R
I
I
A
-
V
L
T
D
D
D
-------
Y
L
K
K
K
L
P
Q
L
--
L
R
D
C
L
L
H
F
L
L
F
R
C
S
L
E
F
L
T
E
L
V
G
D
----
L
P
-
R
C
P
L
G
K
L
R
R
-----------
E
L
Y
V
---
N
C
L
N
--
R
A
I
IST
P
E
Y
K
E
C
L
-------------------
Q
M
L
S
F
-
L
--------
S
K
D
-
E
-----
F
------------------
V
A
K
V
N
R
-----
A
L
E
R
-
T
-
E
Q
F
L
V
E
E
I
-------------------------------------
A
P
L
E
L
G
E
A
C
T
--
A
V
L
R
P
K
L
--
E
A
I
-
R
L
A
V
D
E
------
V
G
R
A
L
Q
K
T
L
Q
L
I
E
T
-
Q
I
V
Q
---
D
H
L
R
-
A
L
Q
-------
D
A
P
P
-----------
I
H
E
L
F
V
--
F
S
D
I
A
-
T
V
R
R
N
I
I
G
A
P
R
A
-------------
A
L
H
T
A
L
N
N
PHFP
D
L
-------------
S
V
----
V
-
Y
-
K
L
H
L
E
C
G
R
M
I
N
L
F
D
W
L
Q
A
F
R
S
V
-------
V
P
Q
I
Q
A
R
F
T
R
A
V
A
E
L
Q
F
L
GYIKMSKRKTD
H
A
T
R
LTW
23
Fugue
65.70
17%
-115
- C6 -
4D0L
2
PI4KB_HUMAN
A:
[10-566]
----------------S
W
L
L
R
L
F
E
S
K
L
F
D
I
-----
S
M
A
-
I
S
Y
L
Y
N
S
K
E
P
---
G
V
Q
---
A
Y
I
G
N
R
L
F
CFR
N
E
D
V
D
F
Y
L
P
Q
-----------
L
L
N
M
Y
-------
I
H
M
D
E
---------
D
V
G
D
A
I
K
P
Y
I
V
H
R
C
-
R
---------------
Q
S
I
N
F
S
L
Q
C
A
L
L
L
-
G
-
A
--------
Y
S
S
----
R
G
T
K
L
--
R
K
L
I
L
S
R
L
A
P
E
R
E
F
I
K
S
--
L
M
A
I
G
K
R
L
--------
A
T
L
-
P
T
K
E
Q
----
K
-
T
Q
R
--
L
I
-----
S
E
L
S
L
--------
L
--
N
H
K
L
P
A
R
V
W
L
P
T
A
------
G
F
D
H
----
H
--
V
-----------
V
----------------------
R
----------------------
V
P
H
--
T
QA
V
V
-----
L
N
S
K
D
----
K
A
P
-
Y
L
I
Y
V
E
-----------
V
L
E
C
E
N
F
D
T
T
S
V
P
-
A
R
I
P
E
-
N
P
S
A
V
------------------------
A
L
K
E
P
W
------
Q
---------
E
K
V
R
R
---
I
R
E
G
S
-
P
-
Y
-------------
G
-----------------------
H
-
L
P
N
------
W
R
L
L
S
V
I
V
K
----
C
G
D
D
L
R
Q
E
L
L
A
F
Q
V
L
K
Q
L
Q
S
I
W
E
Q
------------
E
R
V
P
L
---
W
I
K
P
Y
K
I
-
L
V
I
----------
S
A
D
-------------------------
S
G
M
I
E
P
V
----
V
N
-
A
V
S
I
H
Q
V
K
K
-----------
Q
S
Q
L
---
S
L
L
D
--
Y
F
L
----
Q
E
H
G
S
Y
-------------------
T
T
E
A
F
-
L
--------
S
A
Q
-
R
-----
N
------------------
F
V
Q
S
C
A
-----
G
Y
C
L
-
V
-
C
Y
L
L
Q
V
K
D
-
R
H
N
G
N
----
I
L
--
L
----------------------
D
A
E
G
H
---
I
I
--
H
I
D
F
G
F
I
--
L
S
S
-
S
S
A
F
-
K
------
L
T
T
E
F
V
D
V
M
G
G
L
D
G
-
D
M
F
N
---
Y
Y
K
M
L
M
L
Q
-------
G
L
I
A
A
R
K
H
------
M
D
K
V
V
Q
I
--
V
E
I
M
Q
-
Q
G
S
Q
L
P
C
F
H
G
S
-----------------
S
T
I
R
N
-----
L
-------------
K
E
----
R
-
F
-
H
M
S
M
T
---------
E
E
Q
L
Q
L
L
V
-------
E
Q
M
V
D
G
S
M
R
S
--------------------------
28
Fugue
63.44
18%
-111
- C1 -
4UIR
3
OLHYD_ELIME
A:
[2-646]
NPITSKF
D
K
V
L
N
A
SSEYG
H
V
N
H
E
P
D
S
S
K
E
Q
-----
Q
R
N
-
T
P
Q
K
S
M
P
F
S
D
QIG
N
Y
Q
---
R
N
K
G
I
P
V
Q
-----------
S
Y
DN
S
K
I
Y
I
I
G
SG
I
A
G
M
S
-------
A
A
Y
Y
F
---------
I
R
D
G
H
-
V
P
A
K
N
I
T
F
-
L
E
QLHIDGGSL
D
G
A
G
N
P
T
D
G
Y
I
I
R
G
G
R
E
M
D
M
-
T
-
Y
----
E
N
L
W
D
----
M
F
Q
D
I
--
P
A
L
E
M
P
A
P
Y
S
----
V
L
D
--
E
Y
R
L
I
N
D
N
--------
D
S
N
-
Y
--------
S
-
K
A
R
--
L
I
NNK
G
E
I
K
D
F
S
--------
K
FG
L
N
K
M
D
Q
L
A
I
I
R
L
L
------
L
K
N
K
----
E
--
E
LDDLTIEDYFS
E
----------------------
S
----------------------
F
L
K
S
N
F
--
W
T
-----
F
W
R
T
M
----
F
A
F
-
E
N
W
H
S
L
-----------
L
E
L
K
L
Y
M
H
R
F
L
H
A
-
I
D
G
L
N
----
D
L
S
S
L
V
F
-
P
K
Y
N
Q
Y
D
T
---
F
V
T
P
L
R
K
F
L
Q
E
K
G
V
N
I
H
L
N
T
---------
L
V
K
D
L
---
D
I
H
I
N
-
T
-
E
-------------
G
K
V
V
E
G
I
I
T
E
Q
-----
D
G
K
----
E
V
-
K
I
P
------
V
G
K
N
D
Y
V
I
V
T
T
G
S
M
T
E
D
T
F
Y
G
N
N
K
T
A
P
I
I
G
I
D
N
S
T
S
G
-------
Q
S
A
G
W
K
L
W
K
N
---
L
A
A
K
----------------------
S
E
I
F
--
G
K
P
E
K
F
C
S
--
N
I
E
K
S
A
W
E
S
A
T
L
T
C
----
K
P
-
S
A
L
I
D
K
L
K
E
Y
SVNDPYSGKT
V
T
G
G
---
I
I
T
I
--
T
D
S
----
N
W
L
M
S
F
T
C
N
RQPHFPEQPDD
V
L
V
L
W
V
Y
A
L
F
-
M
--------
D
K
E
G
N
-----
Y
------------------
I
K
K
T
M
L
-----
E
C
T
G
-
D
-
E
I
L
A
E
L
C
Y
-
H
L
G
I
E
----
D
Q
--
L
----------------------
E
N
V
Q
K
N
T
I
V
R
--
T
A
F
M
P
Y
I
TS
M
F
M
-
P
R
A
K
G
D
------
R
P
R
V
V
P
E
G
C
K
--
N
L
-
G
L
V
G
---
Q
F
V
E
-
T
N
N
-------
D
V
V
F
T
M
E
S
------
S
V
R
T
A
R
I
A
V
Y
K
L
L
N
L
N
K
Q
V
P
D
I
N
P
L
Q
Y
-------------
D
I
R
H
L
L
K
A
-----
A
-------------
K
T
----
L
-
N
D
D
K
P
F
V
G
E
G
L
L
R
K
V
L
K
G
T
Y
F
E
H
V
LPAGEEH
E
S
F
I
A
E
H
V
N
K
F
R
E
W
V
K
G
IRG----------------
22
Fugue
62.77
19%
-116
- C2 -
4R4X
2
?
A:
[1-546]
----------A
Q
T
Y
E
I
T
Y
Q
N
S
F
E
G
K
I
N
Q
-------
N
H
I
-
I
S
I
T
N
S
D
K
T
L
---
L
F
N
---
E
K
I
K
N
K
K
A
-----------
D
F
-------------
P
F
E
-------
V
N
E
I
N
------------
R
K
-
N
N
E
V
S
Q
F
A
F
L
---------------
N
N
N
E
I
V
K
T
S
D
N
T
I
-
L
-
A
-
K
----
Q
E
F
K
P
----
T
S
E
T
G
--
K
I
L
G
Y
N
V
K
K
A
----
V
T
S
V
N
S
N
T
I
E
V
W
Y
T
NDLKVKG
G
P
S
-
I
--------
L
-
G
Q
D
LG
L
V
-----
L
K
T
V
R
--------
N
--
G
S
S
V
V
E
A
T
S
V
K
K
I
KALDDQ
S
L
F
N
----
G
K
N
I
-----------
T
----------------------
E
----------------------
K
D
A
--
L
--
T
Y
K
D
M
I
W
K
S
R
F
I
----
T
I
P
-
V
F
E
N
E
T
-----------
I
N
F
S
D
A
S
---
K
S
D
-
Q
V
I
Q
R
-
F
G
N
G
T
I
I
L
K
K
-
V
K
---
I
P
E
---
I
K
Q
G
-------------------------
N
T
I
F
V
---
E
L
K
Q
K
-
S
-
N
-------------
G
D
---
A
Y
---------------------
D
------
R
T
G
D
V
F
I
I
P
Q
E
R
A
I
S
Y
Y
T
G
L
T
Q
G
V
K
S
L
---
P
V
Y
Q
N
G
--------
N
G
K
S
Y
Q
G
V
A
L
TPD
Y
L
P
F
I
E
L
M
R
F
F
T
P
FGIGHFNE
K
I
Q
L
K
G
K
N
W
--
H
N
N
T
P
Y
R
Q
D
I
T
E
L
R
P
Q
L
S
G
-------------------
K
E
-----------
I
L
I
G
---
A
F
I
G
N
Y
D
K
G
----
G
H
Q
I
S
L
-------------------
E
L
S
I
H
-
P
--------
D
Q
Q
-
K
IVNNN
F
------------------
V
L
P
V
F
N
-----
T
T
N
V
M
E
M
A
G
Q
D
Y
-
P
T
M
F
N
S
D
K
----
G
V
--
E
----------------------
V
D
F
I
L
T
K
D
L
K
--
N
A
Q
L
R
Y
I
--
T
T
G
-
H
G
G
W
G
A
GDEF
V
P
K
E
N
S
I
Y
L
D
G
K
L
A
H
A
F
T
P
W
R
TDC
G
S
Y
R
L
F
N
P
ASGNFED
G
L
S
S
S
D
L
S
RSNWCP
G
T
I
T
N
P
V
--
Y
I
N
L
G
-
N
L
N
A
---------------------
G
K
H
T
I
Q
V
K
-----
I
-------------
P
Q
---------
G
A
P
E
G
S
S
Q
S
F
W
N
V
S
G
V
L
L
G
Q
E
-------
H
H
H
------
H
H
H
H
H
----------------------
9
HHSearch
57.84
19%
-131
* C7 *
3D31
-
?
C:
[60-283]
---------------------------------------------------------------------------------------------------------------------------------
I
-
F
---------------
E
Q
I
T
E
D
F
S
G
L
V
K
A
-
A
G
N
-
R
----
S
V
I
S
S
----
I
F
L
S
L
--
Y
A
G
F
L
A
T
L
L
A
----
L
L
L
--
G
A
P
T
G
Y
I
L
--------
A
R
F
-
D
--------
F
P
G
K
R
--
L
V
-----
E
S
I
I
D
--------
V
--
P
V
V
V
P
H
T
V
A
G
I
A
L
------
L
T
V
F
----
G
--
S
-----------
R
----------------------
G
LIGEPLESYIQFRDA-------
L
P
G
--
I
--
V
V
-----
A
M
L
F
V
----
S
M
P
Y
L
A
N
S
A
R
-----------
E
G
F
K
S
V
D
P
R
L
E
N
A
-
A
R
S
L
G
-
A
P
L
W
K
A
F
F
F
V
-
T
L
P
L
S
A
R
Y
---
L
L
I
G
S
V
M
T
W
A
R
A
I
------
S
---------
E
F
G
A
V
---
V
I
L
A
Y
Y
P
-
M
-------------
V
G
---
P
T
L
I
Y
D
-----
R
F
I
----
S
Y
-
G
L
S
------
A
S
R
P
I
A
V
L
L
I
L
V
T
L
S
I
F
L
V
I
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
20
Fugue
56.91
15%
-106
- C6 -
4XGC
1
ORC5_DROME
E:
[1-458]
------------------
M
E
A
I
C
S
S
L
E
P
L
F
-----
P
C
R
------
E
A
A
I
E
---
T
L
G
---
E
L
I
G
D
S
S
E
-----------
T
Y
-------------
P
S
A
-------
I
Y
L
F
G
---------
H
S
G
T
G
-
K
T
A
L
T
R
A
F
-
L
---------------
K
E
C
G
K
R
----
Q
N
V
-
R
-
T
-
A
----
H
L
N
A
I
----
E
C
Y
T
T
--
K
I
M
L
E
I
L
L
D
S
----
L
A
P
--
D
Q
--------------
G
D
A
-
L
--------
K
-
V
D
N
--
M
L
-----
D
F
V
E
Q
--------
L
--
R
R
Q
A
A
T
R
V
E
D
Q
G
F
------
L
I
A
V
----
D
--
N
-----------
A
----------------------
E
----------------------
R
L
R
--
D
--
M
--------
D
A
N
----
V
L
P
-
V
L
L
----------------------
R
L
Q
E
L
-
T
-------------
N
L
-
N
L
C
V
I
L
L
S
---
Q
L
P
F
E
K
F
Y
N
K
T
G
L
------
S
---------
E
I
V
C
L
---
H
L
A
------------------------
Q
Y
N
K
A
E
-----
T
Q
R
----
I
L
-
G
S
D
-------------------
F
Q
Q
V
R
N
Q
L
L
E
Q
K
K
R
L
E
I
C
Q
E
A
V
T
-------------
E
D
F
Y
N
---
N
Y
L
N
L
F
L
-
S
V
F
----------
Y
K
A
C
R
D
V
P
E
--
L
Q
L
T
A
R
K
C
L
S
T
Y
L
E
P
V
L
D
G
T
--
S
R
----
L
W
-
R
H
I
A
G
P
L
R
S
-----------
A
L
T
Q
---
I
Y
M
R
--
I
E
--------------------------------------------------------------------------------------------------------------
S
L
--
E
----------------------
L
P
Y
Y
A
K
F
L
L
I
--
A
A
F
L
A
S
H
--
N
A
A
-
K
Q
D
K
R
L
------
F
S
T
T
L
G
P
-----
K
S
-
F
S
I
D
---
R
L
L
A
I
F
Y
A
-------
I
L
E
E
K
V
G
L
------
T
C
N
L
L
S
Q
--
I
S
T
L
V
-
H
L
N
L
L
S
F
V
S
G
E
Q
-------------
N
I
M
E
--------------------------------------
G
S
A
R
L
Q
C
T
I
G
L
E
F
V
L
Q
I
-------
G
K
V
V
G
F
N
V
R
Q
Y
L
C
D
----------------------
11
HHSearch
55.79
18%
-91
- C7 -
3D31
-
?
C:
[63-283]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Q
I
T
E
D
F
S
G
L
V
K
A
A
G
N
R
S
----
V
I
-
S
S
I
F
L
S
L
Y
A
-----------
G
F
L
A
---
T
L
L
A
--
L
L
L
----
G
A
P
T
G
Y
-------------------
I
L
A
R
F
-
D
F-------
P
G
K
-
R
-----
L
------------------
V
E
S
I
I
D
-----
V
P
V
V
-
V
-
P
H
T
V
A
G
I
A
-
L
L
T
V
F
----
G
S
--
R
GLIGEPLESYIQFRD-------
A
L
P
G
I
V
V
A
M
L
--
F
V
S
M
P
Y
L
A-
N
S
A
-
R
E
G
F
K
S
------
V
D
P
R
L
E
N
A
A
R
S
L
G
A
-
P
L
W
K
---
A
F
F
F
V
T
L
P
-------
L
S
A
R
Y
L
L
I
------
G
S
V
M
T
W
A
--
R
A
I
S
E
-
F
G
A
V
V
I
L
A
Y
Y
P
M
-------------
V
G
P
T
L
I
Y
D
-----
R
-------------
F
I
----
S
-
Y
-
G
L
S
A
S
R
P
I
A
V
L
L
I
L
V
T
L
S
I
F
L
V
-------
I
R
----------------------------------
12
HHSearch
55.31
18%
-141
- C7 -
2ONK
-
WTPB_ARCFU
C:
[58-275]
---------------------------------------------------------------------------------------------------------------------------------------------------------
F
D
E
F
L
K
A
-
A
S
D
-
P
----
A
V
W
K
V
----
V
L
T
T
Y
--
Y
A
A
L
I
S
T
L
I
A
----
V
I
F
--
G
T
P
L
A
Y
I
L
--------
A
R
K
-
S
--------
F
P
G
K
S
--
V
V
-----
E
G
I
V
D
--------
L
--
P
V
V
I
P
H
T
V
A
G
I
A
L
------
L
V
V
F
----
G
--
S
-----------
S
----------------------
G
LIGSFSPLKFVDA---------
L
P
G
--
I
--
V
V
-----
A
M
L
F
V
----
S
V
P
I
Y
I
N
Q
A
K
-----------
E
G
F
A
S
V
D
V
R
L
E
H
V
-
A
R
T
L
G
-
S
S
P
L
R
V
F
F
T
V
-
S
L
P
L
S
V
R
H
---
I
V
A
G
A
I
M
S
W
A
R
G
I
------
S
---------
E
F
G
A
V
---
V
V
I
A
Y
Y
P
-
M
-------------
I
A
---
P
T
L
I
Y
E
-----
R
Y
L
----
S
E
-
G
L
S
------
A
A
M
P
V
A
A
I
L
I
L
L
S
L
A
V
F
V
A
L
R
I
I
V
G
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
16
HHSearch
54.54
18%
-85
- C7 -
3TUI
-
METI_ECOLI
A:
[7-216]
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
L
----
L
V
-
R
G
V
W
E
T
L
A
M
-----------
T
F
V
S
---
G
F
F
G
--
F
V
I
----
G
L
P
V
G
V
-------------------
L
L
Y
V
T
-
R
PGQIIAN
A
K
L
Y
-
R
-----
T
------------------
V
S
A
I
V
N
-----
I
F
R
S
-
I
-
P
F
I
I
L
L
V
W
-
M
I
P
F
T
R
V
I
V
G
T
S-
I
----------------------
G
L
Q
A
A
I
V
P
L
T
--
V
G
A
A
P
F
I
A
-
R
M
V
-
E
N
A
L
L
E
------
I
P
T
G
L
I
E
A
S
R
A
M
G
A
-
T
P
M
Q
---
I
V
R
K
V
L
L
P
-------
E
A
L
P
G
L
V
N
------
A
A
T
I
T
L
I
--
T
L
V
G
Y
-
S
A
M
G
G
A
V
-
G
-
A
G
-------------
G
L
G
Q
I
G
Y
Q
-----
Y
-------------
G
Y
----
I
G
Y
-
N
A
T
V
M
N
T
V
L
V
L
L
V
I
L
V
Y
L
I
Q
F
A
-------
G
D
R
I
V
R
A
V
T
R
--------------------------
10
HHSearch
52.68
14%
-99
- C7 -
2ONK
-
WTPB_ARCFU
C:
[60-275]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
E
F
L
K
A
A
S
D
P
A
----
V
W
-
K
V
V
L
T
T
Y
Y
A
-----------
A
L
I
S
---
T
L
I
A
--
V
I
F
----
G
T
P
L
A
Y
-------------------
I
L
A
R
K
-
S
F-------
P
G
K
-
S
-----
V
------------------
V
E
G
I
V
D
-----
L
P
V
V
-
I
-
P
H
T
V
A
G
I
A
-
L
L
V
V
F
----
G
S
--
S
GLIGSFSPLKFVD---------
A
L
P
G
I
V
V
A
M
L
--
F
V
S
V
P
I
Y
--
I
N
Q
A
K
E
G
F
A
S
------
V
D
V
R
L
E
H
V
A
R
T
L
G
S
-
S
P
L
R
---
V
F
F
T
V
S
L
P
-------
L
S
V
R
H
I
V
A
------
G
A
I
M
S
W
A
--
R
G
I
S
E
-
F
G
A
V
V
V
I
A
Y
Y
P
M
-------------
I
A
P
T
L
I
Y
E
-----
R
-------------
Y
L
----
S
-
E
-
G
L
S
A
A
M
P
V
A
A
I
L
I
L
L
S
L
A
V
F
V
A
-------
L
R
I
I
V
G
------------------------------
13
HHSearch
51.47
16%
-127
- C7 -
3TUI
-
METI_ECOLI
A:
[6-215]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------
M
-
W
----
L
L
V
R
G
----
V
W
E
T
L
--
A
M
T
F
V
S
G
F
F
G
----
F
V
I
--
G
L
P
V
G
V
L
L
--------
Y
V
T
-
R
PGQIIAN
A
K
-
L
Y
R
--
T
V
-----
S
A
I
V
N
--------
I
--
F
R
S
I
P
F
I
I
L
L
V
W
M
------
I
P
F
T
R
V
I
V
G
--
T
SI---------
G
----------------------
L
----------------------
Q
A
A
--
I
--
V
P
-----
L
T
V
G
A
----
A
P
F
-
I
A
R
M
V
E
-----------
N
A
L
L
E
I
P
T
G
L
I
E
A
-
S
R
A
M
G
-
A
T
P
M
Q
I
V
R
K
V
-
L
L
P
E
A
L
P
G
---
L
V
N
A
A
T
I
T
L
I
T
L
V
------
G
---------
Y
S
A
M
G
---
G
A
V
G
A
---
G
-------------
G
L
---
G
Q
I
G
Y
Q
-----
Y
G
Y
----
I
G
Y
N
A
T
------
V
M
N
T
V
L
V
L
L
V
I
L
V
Y
L
I
Q
F
A
G
D
R
I
V
R
A
V
T
R
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
15
HHSearch
51.00
13%
-134
- C7 -
3RLF
2
MALF_ECOLI
F:
[261-503]
---------------------------------------------------------------------------------------------------------------------------------------------------------
W
K
N
F
T
R
V
-
F
-
T
D
E
GIQK
P
F
L
A
I
----
F
V
W
T
V
--
V
F
S
L
I
T
V
F
L
T
----
V
A
V
--
G
M
V
L
A
C
L
V
--------
Q
W
E
A
L
--------
R
-
G
K
A
--
V
Y
-----
R
V
L
L
I
--------
L
--
P
Y
A
V
P
S
F
I
S
I
L
I
F
------
K
G
L
F
----
N
--
Q
-----------
S
FG--------------------
E
INMMLSALFGVKPAWFSDPTTA
R
T
M
--
L
--
I
I
-----
V
N
T
W
L
----
G
Y
P
Y
M
M
I
L
C
M
-----------
G
L
L
K
A
I
P
D
D
L
Y
E
A
-
S
A
M
D
G
-
A
G
P
F
Q
N
F
F
K
I
-
T
L
P
L
L
I
K
P
---
L
T
P
L
M
I
A
S
F
A
F
N
F
------
N
---------
N
F
V
L
I
---
Q
L
L
T
N
-
G
G
P
DRLGTTTPAGYTD
L
L
---
V
N
Y
T
Y
R
-----
I
A
F
EGGG
G
Q
-
D
F
G
------
L
A
A
A
I
A
T
L
I
F
L
L
V
G
A
L
A
I
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
26
Fugue
48.23
11%
-116
- C3 -
4HVT
8
?
A:
[20-710]
-----------NPKETKF
L
E
E
A
E
G
V
E
A
L
E
W
A
K
E
R
T
S
K
T
-
E
K
A
L
Q
A
M
Q
E
Y
---
K
Q
I
---
K
K
E
I
E
T
I
F
Y
DQRKTP
Y
---
G
V
-----------
I
R
K
G
Y
-------
V
Y
N
F
W
M
D
DKNPQGL
W
R
R
T
L
-
V
D
N
Y
S
K
D
K
-
P
---------------
N
W
E
V
L
I
D
F
D
K
L
S
K
-
K
-
I
-
G
----
K
K
V
A
Y
----
R
G
V
S
N
C
F
Q
N
P
N
R
Y
L
I
S
M
----
S
F
G
--
G
K
D
E
M
F
F
R
--------
E
W
D
-
L
--------
E
-
K
K
D
--
F
V
-----
K
N
G
F
E
PITNSG
K
L
L
--
E
G
K
F
T
Y
P
T
W
I
N
K
D
------
T
I
I
F
----
N
--
L
-----------
V
LHKNEITSSLYPN
S
L
Y
I
W
K
R
GE
S
----------------------
I
E
K
--
A
--
K
K
-----
L
F
E
V
P
----
K
E
Y
-
I
Y
V
S
A
G
K
LLSDTISSS
L
I
F
I
S
A
N
K
D
F
Y
N
Y
D
-
N
Y
I
L
D
T
K
Y
K
N
L
K
L
Q
K
I
-
N
M
P
S
D
A
T
L
QGS
F
K
E
Y
V
F
W
L
L
R
S
D
W
------
K
FKSHNIKAG
S
L
V
A
L
H
FT
D
L
L
K
T
-
E
-
S
-------------
D
K
---
T
S
L
K
I
L
F
T
P
T
A
N
E
V
----
F
N
-
F
I
S
T
T
KD
R
V
F
L
A
T
Y
D
N
V
V
A
K
V
V
T
F
T
L
E
N
E
Q
W
T
K
P
V
V
L
K
L
P
Y
Q
N
A
I
F
G
M
S
S
Y
E
E
E
E
E
A
L
I
T
I
E
N
---
S
I
V
P
P
T
I
-
Y
L
W
----------
V
K
T
H
E
L
K
I
I
RK
A
L
Y
S
F
D
S
E
N
Y
V
L
E
Q
K
E
A
T
S
F
D
G
V
K
----
I
P
-
Y
F
L
V
Y
K
K
G
I
-----------
K
F
D
G
KNP
T
L
L
E
--
A
Y
G
----
G
F
Q
V
I
N
-------------------
A
P
Y
F
S
-
R
--------
I
K
N
-
E
-----
V
WVKNA
G
V
S
V
L
A
NIRGGGE
F
G
P
E
W
H
K
S
A
QG
I
K
R
Q
-
T
-
A
F
N
D
F
F
A
V
-
S
E
E
L
I
K
Q
--
N
I
--
T
----------------------
S
P
E
Y
L
G
I
K
G
G
S
N
G
G
L
L
V
S
V
--
A
M
T
-
Q
R
-----------
P
E
L
F
G
A
V
A
C
E
V
P
I
-
L
D
M
I
---
R
Y
K
E
F
G
A
G
-------
H
S
W
V
T
E
Y
G
------
D
P
E
I
P
N
D
--
L
L
H
I
K
-
K
Y
A
P
L
E
N
L
S
L
T
Q
-------------
K
Y
P
T
V
L
I
T
-----
D
S
VLDQRVHP
W
H
G
R
I
F
----
E
-
Y
-
V
L
A
Q
N
P
N
T
K
T
Y
F
L
E
S
K
D
S
G
H
G
S
-------
G
S
D
L
K
E
S
A
N
Y
F
I
N
L
Y
T
F
F
A
N
A
L
KLKI----------
27
Fugue
45.51
12%
-107
- C4 -
3OKG
8
?
A:
[15-412]
------------------
M
T
E
G
P
Y
K
L
P
P
G
W
-----
R
W
V
R
L
G
E
V
C
L
P
T
E
R
---
R
D
P
---
T
K
N
P
S
T
Y
F
-----------
V
Y
-----------
V
-----------------------------------
D
I
S
A
-
I
---------------
D
S
T
V
G
K
I
V
S
P
K
E
I
-
L
-
G
-
Q
----
H
A
P
S
R
----
A
R
K
V
I
--
R
S
---
G
D
V
I
F
----
A
T
T
--
R
P
Y
L
K
N
I
A
--------
L
V
P
-
P
--------
D
-
L
D
G
--
Q
I
-----
C
S
T
G
F
--------
C
--
V
I
R
A
N
R
E
F
A
E
P
E
F
------
L
F
H
L
----
C
--
R
-----------
S
----------------------
D
----------------------
F
I
T
--
N
--
Q
L
-----
T
A
S
K
M
RGTS
Y
P
A
-
V
T
D
N
D
V
-----------
Y
N
T
L
I
P
L
P
P
L
E
E
Q
-
R
R
I
V
A
-
K
V
E
A
L
M
E
R
V
R
-
E
V
R
R
L
R
A
E
---
A
Q
K
D
T
E
L
L
M
Q
T
A
L
------
A
---------
E
V
F
P
H
---
P
G
A
D
L
-
P
-
P
-------------
G
-------------------------------------------------------
W
R
W
V
R
L
G
E
V
C
D
I
I
M
G
Q
------
S
P
P
S
S
T
Y
N
F
----------------------------
E
G
N
G
L
P
F
--
F
Q
G
K
A
D
F
G
D
L
H
P
T
P
R
I
W
C
S
A
P
Q
K
V
----
A
R
P
G
D
V
L
I
S
V
R
A
-----------
P
V
G
S
---
T
N
V
A
--
N
L
A
----
C
C
I
G
R
G
-------------------
L
A
A
L
R
-
P
--------
R
D
S
-------------------------------------------------------------------------------------------------
L
E
--
R
F
W
L
L
Y
Y
--
L
H
Y
-
L
E
P
E
L
S
------
K
A
I
T
K
K
D
L
Q
N
--------------
V
F
I
P
L
P
-------
P
L
E
E
Q
R
R
I
------
V
A
Y
L
D
Q
I
--
Q
Q
Q
V
A
-
A
L
K
R
A
Q
--------------------------------
A
-------------
E
T
----
E
-
A
-
E
L
K
R
L
E
Q
A
I
L
D
K
A
F
R
G
D
L
-----------------------------------------------
14
HHSearch
41.52
12%
-99
- C7 -
3RLF
2
MALF_ECOLI
F:
[262-503]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
N
F
T
R
V
F
T
D
E
G
IQKP
F
L
-
A
I
F
V
W
T
V
V
F
-----------
S
L
I
T
---
V
F
L
T
--
V
A
V
----
G
M
V
L
A
C
-------------------
L
V
Q
W
E
A
L
--------
R
G
K
-
A
-----
V
------------------
Y
R
V
L
L
I
-----
L
P
Y
A
-
V
-
P
S
F
I
S
I
L
I
-
F
K
G
L
F
----
N
Q
SF
G
EINMMLSALFGVKPAWFSDPTT
A
R
T
M
L
I
I
V
N
T
--
W
L
G
Y
P
Y
M
M-
I
L
C
-
M
G
L
L
K
A
------
I
P
D
D
L
Y
E
A
S
A
M
D
G
A
-
G
P
F
Q
---
N
F
F
K
I
T
L
P
-------
L
L
I
K
P
L
T
P
------
L
M
I
A
S
F
A
--
F
N
F
N
N
-
F
V
L
I
Q
L
L
T
N
G
G
P
DRLGTTTPAGYTD
L
L
V
N
Y
T
Y
R
-----
I
-------------
A
F
EGGG
G
-
Q
-
D
F
G
L
A
A
A
I
A
T
L
I
F
L
L
V
G
A
L
A
I
--------------------------------------------
17
HHSearch
33.30
13%
133
* C5 *
1ETO
-
FIS_ECOLI
A:
[62-92]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
L
L
D
-----------
M
V
M
Q
Y
T
L
G
N
Q
T
R
A
-
A
L
M
M
G
-
I
N
R
G
T
L
R
K
K
L
-
K
K
Y
G
M
N
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
7
PsiBlast_CBE
28.73
36%
16
- C5 -
3ZHB
1
?
C:
[123-178]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
A
D
G
R
G
A
D
Y
--
L
D
G
A
I
L
A
G
P
A
A
I
G
T
A
D
A
V
V
L
L
S
G
------
P
-
R
S
A
F
D
P
H
A
S
-----------
A
L
G
G
-----
L
G
--
A
G
T
----
T
Y
L
G
A
D
-------------------
H
G
L
A
S
-
L
--------
Y
D
A
-
A
-----
G
------------------
L
V
M
M
W
S
-----
I
L
N
G
-
F
-
L
Q
G
A
A
L
L
G
-
T
A
G
V
D
----
A
T
--
T
----------------------
F
A
P
F
I
T
Q
G
I
G
--
T
V
A
D
W
L
P
--
G
Y
A
-
R
Q
I
D
D
G
------
A
Y
P
A
D
D
A
A
I
D
T
H
L
A
-
T
M
E
H
---
L
I
H
E
S
E
F
L
-------
G
V
N
A
E
L
P
R
------
F
I
K
A
L
A
D
--
R
A
V
A
D
-
G
H
G
G
S
G
Y
P
A
L
I
E
-------------
Q
F
R
T
H
-------------------------------------------------------------------------------------------------
3
PsiBlast_PDB
28.10
31%
17
- C5 -
1PS1
-
PENA_STREX
A:
[95-145]
-------------------
K
Q
L
T
D
Q
V
A
A
A
L
-----
D
G
P
-
L
P
D
T
A
P
P
I
A
H
---
G
F
A
D
I
W
R
R
T
C
E
G
M
T
-----------
P
---------------------------
A
W
---------
C
A
R
S
A
-
R
H
W
R
N
Y
F
D
-
G
---------------
Y
V
D
E
A
E
S
R
S
A
A
Q
Y
-
L
-
A
-
M
----
R
R
H
T
I
----
G
V
Q
P
T
--
V
D
L
A
E
R
A
G
R
F
----
E
V
P
--
H
R
V
F
D
S
A
V
--------
M
S
A
-
M
--------
L
-
Q
I
A
--
V
D
-----
V
N
L
L
L
--------
N
--
D
I
A
S
L
E
K
E
E
A
R
G
E
------
Q
N
N
M
----
V
--
M
-----------
I
----------------------
L
----------------------
R
R
E
--
H
--
G
W
-----
S
K
S
R
S
----
V
S
H
-
M
Q
N
E
V
R
-----------
A
R
L
E
Q
Y
L
L
L
E
S
C
L
-
P
K
V
G
E
-
I
Y
Q
L
D
T
A
E
R
E
-
A
L
E
R
Y
R
T
D
---
A
V
R
T
V
I
R
G
S
Y
D
W
H
------
R
---------
S
S
G
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
2
PsiBlast_PDB
28.04
31%
24
- C5 -
1HM7
-
PENA_STREX
A:
[95-145]
-------------------
K
Q
L
T
D
Q
V
A
A
A
L
-----
D
G
P
-
L
P
D
T
A
P
P
I
A
H
---
G
F
A
D
I
W
R
R
T
C
E
G
M
T
-----------
P
---------------------------
A
W
---------
C
A
R
S
A
-
R
H
W
R
N
Y
F
D
-
G
---------------
Y
V
D
E
A
E
S
R
A
A
Q
Y
L
-
A
-
M
-
R
----
R
H
T
I
G
----
V
Q
P
T
V
--
D
L
A
E
R
A
G
R
F
E
----
V
P
H
--
R
V
F
D
S
A
V
M
--------
S
A
M
-
L
--------
Q
-
I
A
V
--
D
V
-----
N
L
L
L
L
--------
D
--
I
A
S
L
E
K
E
E
A
R
N
M
V
------
M
I
K
S
----
R
--
S
-----------
V
----------------------
S
----------------------
H
M
Q
--
N
--
E
V
-----
R
A
R
L
E
----
Q
Y
L
-
L
L
E
S
C
L
-----------
P
K
V
G
E
I
Y
Q
L
D
T
A
E
-
R
E
A
L
E
-
R
Y
R
T
D
A
V
R
T
V
-
I
R
G
S
Y
D
W
H
---
R
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
6
PsiBlast_CBE
28.03
36%
18
- C5 -
3ZHB
1
?
D:
[123-178]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
W
A
D
G
R
G
A
D
Y
--
L
D
G
A
I
L
A
G
P
A
A
I
G
T
A
D
A
V
V
L
L
S
G
------
P
-
R
S
A
F
D
P
H
A
S
-----------
A
L
G
G
-----
L
G
--
A
G
T
----
T
Y
L
G
A
D
-------------------
H
G
L
A
S
-
L
--------
Y
D
A
-
A
-----
G
------------------
L
V
M
M
W
S
-----
I
L
N
G
-
F
-
L
Q
G
A
A
L
L
G
-
T
A
G
V
D
----
A
T
--
T
----------------------
F
A
P
F
I
T
Q
G
I
G
--
T
V
A
D
W
L
P
--
G
Y
A
-
R
Q
I
D
D
G
------
A
Y
P
A
D
D
A
A
I
D
T
H
L
A
-
T
M
E
H
---
L
I
H
E
S
E
F
L
-------
G
V
N
A
E
L
P
R
------
F
I
K
A
L
A
D
--
R
A
V
A
D
-
G
H
G
G
S
G
Y
P
A
L
I
E
-------------
Q
F
R
T
H
-------------------------------------------------------------------------------------------------