@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0191: (2015-12-25 )
MDLRQLRYFIALAEHRSFVRAADAMGITQPAFSRSIQGLEQELGCQLVDRGSKDLRPTPEGQVVLQHALSLVQGSANLIHEIAQLNKLDAGELRFGSGPAPAQQLVPDAVADFINRHPRVQISLDVDNWEKLSRALLREEIEFFVADIRDFEADPNFQTRPLTPRRGQFFCRPQHPLLGKDSLSTNDLFNYPLASTLIPPGIRKLLANLSGKIDFAANIRCENMHALIRIVRQTDAIGIASDETLRPYLQRGELQPLQWRNLPQNLDSLSARCGIISRSGYRLSAAAKAMIETLVELDQAQHAAA
Atome Classification :
(20 SA)
-----.........10........20........30........40........50........60........70---..-......80.....-...-------90........100.......110.......120.......130.......-140.......150.-.......160-.......170.....--..-180.........190-..--.....200.--...----.-.-...210-.......220--.....-..230........240.......250.....-...260........270.......280.......290.......300...
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
-----M
D
L
R
Q
L
R
Y
F
I
A
L
A
E
H
R
S
F
V
R
A
A
D
AMGIT
Q
P
A
F
S
R
S
I
Q
G
L
E
Q
E
LG
C
Q
L
V
DRGSKDLRPTPE
G
Q
V
V
L
Q
H
A
L
S
L
---VQ-G
S
A
N
L
I
H
E
I
A
Q
L
N-KLD-------AGELRFGSGPA
P
A
Q
Q
L
V
P
D
A
V
A
D
F
I
NRHP
R
V
Q
I
S
L
DVD
N
W
E
K
L
S
R
A
L
L
R
E
-
E
I
E
F
F
V
A
D
I
R
DF-E-ADPNFQTRPL-TPRRG
Q
F
F
CRPQHPL--LG-K--DSLSTNDLFNYP-
L
A
--
S
TLI
P
P
--
G
--
I
R
K
----
L
-
L
-
A
NLSG
K
-
I
D
F
A
A
N
I
R
C
E
--
N
M
H
A
L
-
I
R
I
-
V
R
QTDAIGIAS
D
E
T
L
R
P
Y
L
Q
R-GELQ
P
-
L
Q
WRN-LP
Q
N
L
D
S
L
S
A
RC
G
I
ISRSGY
R
L
S
A
A
A
K
A
M
I
E
T
L
V
E
L
D
Q
A
QHAAA
30
HHSearch
87.24
23%
-96
* C3 *
3FXQ
7
TSAR_COMTE
A:
[2-296]
-----
L
K
L
Q
T
L
Q
A
L
I
C
I
E
E
V
G
S
L
R
A
A
A
Q
L
L
H
L
S
Q
P
A
L
S
A
A
I
Q
Q
L
E
D
E
L
K
A
P
L
L
V
R
T
K
R
G
V
S
L
T
S
F
G
Q
A
F
M
K
H
A
R
L
I
---
V
T
-
E
S
R
R
A
Q
E
E
I
G
Q
L
R
-
G
R
W
-------
E
G
H
I
T
F
A
A
S
P
A
I
A
L
A
A
L
P
L
A
L
A
S
F
A
R
E
F
P
D
V
T
V
N
V
R
D
G
M
Y
P
A
V
S
P
Q
L
R
D
G
-
T
L
D
F
A
L
T
A
A
H
K
H
-
D
-
I
D
T
D
L
E
A
Q
P
L
-
Y
V
S
D
V
V
I
V
G
Q
R
Q
H
P
M
--
A
N
-
A
----
T
R
L
A
E
L
Q
E
C
R
-
W
A
--
F
S
S
A
P
R
--
G
--
P
G
A
I
I
R
-
N
-
A
F
A
R
Y
G
L
P
-
E
P
K
L
G
-
L
V
C
E
--
S
F
L
A
L
-
P
G
V
-
V
A
H
S
D
L
L
T
T
M
P
R
T
L
Y
E
R
N
A
F
K
-
D
Q
L
C
S
-
I
P
L
Q
D
-
A
L
-----
P
N
P
T
I
Y
V
L
R
R
H
D
L
P
V
T
P
A
A
A
G
L
I
R
W
I
Q
H
H
A
L
------
38
HHSearch
80.35
20%
-76
- C3 -
3HHG
-
?
A:
[3-294]
-----
T
N
S
E
E
L
T
V
F
V
Q
V
V
E
S
G
S
F
S
R
A
A
E
Q
L
A
M
A
N
S
A
V
S
R
I
V
K
R
L
E
E
K
L
G
V
N
L
L
N
R
T
T
R
Q
L
S
L
T
E
E
G
A
Q
Y
F
R
R
A
Q
R
I
---
L
Q
-
E
M
A
A
A
E
T
E
M
L
A
V
H
-
E
I
P
-------
Q
G
V
L
S
V
D
S
A
M
P
M
V
L
H
L
L
A
P
L
A
A
K
F
N
E
R
Y
P
H
I
R
L
S
L
V
S
S
E
---
G
Y
I
N
L
I
E
R
-
K
V
D
I
A
L
R
A
G
E
L
D
----
D
S
G
L
R
A
R
H
L
-
F
D
S
R
F
R
V
I
A
S
P
E
Y
L
A
--
K
H
-
G
--
T
P
Q
S
T
E
E
L
A
G
H
Q
-
C
L
--
G
F
T
E
P
G
--
S
--
L
N
T
W---
A
V
L
-
D
A
Q
G
N
P
Y
K
I
S
P
H
-
F
T
A
S
--
S
G
E
I
L
-
R
S
L
-
C
L
S
G
C
G
I
V
C
L
S
D
F
L
V
D
N
D
I
A
E
-
G
K
L
I
P
-
L
L
A
E
Q
T
S
D
-----
K
T
H
P
F
N
A
V
Y
Y
S
D
K
A
V
N
L
R
L
R
V
F
L
D
F
L
V
E
E
L
G
------
54
Fugue
78.60
18%
-80
- C3 -
2ESN
-
?
A:
[3-303]
PLLRR
L
D
L
N
L
L
L
V
F
D
A
L
Y
R
H
R
N
V
G
T
A
A
S
E
L
A
I
S
A
S
A
F
S
H
A
L
G
R
L
R
Q
G
L
D
D
E
L
F
L
R
Q
G
N
R
M
Q
P
T
Q
R
A
E
H
L
A
A
A
V
A
A
A
---
L
R
-
A
L
G
E
G
L
E
E
W
R
P
F
V
P
G
Q
S
-------
Q
R
T
F
V
F
A
A
T
D
Y
T
A
F
A
L
L
P
P
L
M
N
R
L
Q
H
S
A
P
G
V
R
L
R
L
V
N
A
E
R
K
L
S
V
E
A
L
A
S
G
-
R
I
D
F
A
L
G
Y
D
E
E
H
E
R
-
L
P
E
G
I
Q
A
H
D
W
-
F
A
D
R
Y
V
V
V
A
R
R
D
H
P
R
--
L
A
-
G
---
A
P
T
L
E
G
Y
L
A
E
R
-
H
A
--
V
V
T
P
W
N
--
E
--
D
S
G
----
V
-
I
-
D
R
L
L
A
R
-
S
G
L
R
R
E
V
A
V
Q
LP
T
V
L
A
A
-
L
F
L
-
A
G
S
T
D
F
L
L
T
A
P
R
H
A
A
R
A
L
A
E
A
-
A
---
G
-
L
A
L
Y
P
-
A
P
F
D
I
P
P
Y
V
L
R
L
Y
S
H
V
Q
G
----
R
D
A
H
A
W
M
I
G
Q
L
K
G
L
D
-------
53
Fugue
78.49
21%
-86
- C3 -
3FZV
1
?
A:
[4-300]
-----
Y
T
L
R
Q
L
K
Y
F
V
T
T
V
E
C
G
S
V
A
E
A
S
R
K
L
Y
I
A
Q
S
-
I
S
T
A
V
K
G
L
E
E
S
F
V
---------
Q
L
F
L
T
P
A
G
A
R
F
Y
R
K
A
Q
E
L
---
L
R
M
A
H
E
F
E
Q
N
L
--
A
D
N
-
D
V
I
-------
A
G
Q
I
D
I
G
C
F
E
T
V
A
P
L
Y
L
P
G
L
I
A
G
F
R
Q
A
Y
P
G
V
E
I
R
I
R
D
G
E
Q
Q
E
L
V
Q
G
L
T
S
G
-
R
F
D
L
A
F
L
Y
E
H
D
L
----
D
S
T
I
E
T
E
P
L
M
P
P
Q
R
P
H
A
L
L
P
E
G
H
R
F
--
A
G
-
Q
--
A
Q
V
S
L
R
D
L
C
L
E
P
M
I
----
L
L
D
V
Q
--
P
--
S
R
T
----
Y
-
F
-
V
S
L
F
E
E
-
L
G
L
T
P
N
I
A
F
S
--
S
P
S
I
E
M
V
R
G
M
V
G
Q
G
F
G
F
S
L
L
V
T
R
P
H
S
E
C
T
Y
D
-
G
K
K
V
V
M
V
D
L
A
E
-
P
V
S
T
S
G
-----
L
A
A
A
W
L
K
R
A
Q
L
T
K
P
A
R
L
F
V
D
Y
C
R
E
Q
L
G
K
-----
12
PsiBlast_PDB
78.33
27%
-99
- C3 -
3FXU
12
TSAR_COMTE
A:
[2-237]
-----
L
K
L
Q
T
L
Q
A
L
I
C
I
E
E
V
G
S
L
R
A
A
A
Q
L
L
H
L
S
Q
P
A
L
S
A
A
I
Q
Q
L
E
D
E
L
K
A
P
L
L
V
R
T
K
R
G
V
S
L
T
S
F
G
Q
A
F
M
K
H
A
R
L
I
---
V
T
-
E
S
R
R
A
Q
E
E
I
G
Q
L
R
-
G
R
W
-------
E
G
H
I
T
F
A
A
S
P
A
I
A
L
A
A
L
P
L
A
L
A
S
F
A
R
E
F
P
D
V
T
V
N
V
R
D
G
M
Y
P
A
V
S
P
Q
L
R
D
G
-
T
L
D
F
A
L
T
A
A
H
K
H
-
D
-
I
D
T
D
L
E
A
Q
P
L
-
Y
V
S
D
V
V
I
V
G
Q
R
Q
H
P
M
--
A
N
-
A
--
T
R
L
A
E
L
Q
E
C
R
W
A
-
F
S
--
S
A
P
R
G
P
--
G
A
I
I
R
N
----
A
-
F
-
A
R
Y
-
G
L
-
P
E
P
K
L
G
L
V
C
E
--
S
F
L
A
L
-
P
G
V
-
V
A
H
S
D
L
L
T
T
M
P
R
T
L
Y
E
R
N
A
F
K
-
D
Q
L
C
S
-
I
P
L
Q
D
-
A
L
P
N
P
T
I
Y
V
L
R
R
H
D
L
P
V
T
P
A
A
A
G
L
I
R
W
I
Q
H
H
A
L
-----------
11
PsiBlast_PDB
78.27
27%
-98
- C3 -
3FXR
9
TSAR_COMTE
A:
[2-237]
-----
L
K
L
Q
T
L
Q
A
L
I
C
I
E
E
V
G
S
L
R
A
A
A
Q
L
L
H
L
S
Q
P
A
L
S
A
A
I
Q
Q
L
E
D
E
L
K
A
P
L
L
V
R
T
K
R
G
V
S
L
T
S
F
G
Q
A
F
M
K
H
A
R
L
I
---
V
T
-
E
S
R
R
A
Q
E
E
I
G
Q
L
R
-
G
R
W
-------
E
G
H
I
T
F
A
A
S
P
A
I
A
L
A
A
L
P
L
A
L
A
S
F
A
R
E
F
P
D
V
T
V
N
V
R
D
G
M
Y
P
A
V
S
P
Q
L
R
D
G
-
T
L
D
F
A
L
T
A
A
H
K
H
-
D
-
I
D
T
D
L
E
A
Q
P
L
-
Y
V
S
D
V
V
I
V
G
Q
R
Q
H
P
M
--
A
N
-
A
--
T
R
L
A
E
L
Q
E
C
R
W
A
-
F
S
--
S
A
P
R
G
P
--
G
A
I
I
R
N
----
A
-
F
-
A
R
Y
-
G
L
-
P
E
P
K
L
G
L
V
C
E
--
S
F
L
A
L
-
P
G
V
-
V
A
H
S
D
L
L
T
T
M
P
R
T
L
Y
E
R
N
A
F
K
-
D
Q
L
C
S
-
I
P
L
Q
D
-
A
L
P
N
P
T
I
Y
V
L
R
R
H
D
L
P
V
T
P
A
A
A
G
L
I
R
W
I
Q
H
H
A
L
-----------
13
PsiBlast_PDB
78.13
27%
-97
- C3 -
3FZJ
-
TSAR_COMTE
A:
[2-237]
-----
L
K
L
Q
T
L
Q
A
L
I
C
I
E
E
V
G
S
L
R
A
A
A
Q
L
L
H
L
S
Q
P
A
L
S
A
A
I
Q
Q
L
E
D
E
L
K
A
P
L
L
V
R
T
K
R
G
V
S
L
T
S
F
G
Q
A
F
M
K
H
A
R
L
I
---
V
T
-
E
S
R
R
A
Q
E
E
I
G
Q
L
R
-
G
R
W
-------
E
G
H
I
T
F
A
A
S
P
A
I
A
L
A
A
L
P
L
A
L
A
S
F
A
R
E
F
P
D
V
T
V
N
V
R
D
G
M
Y
P
A
V
S
P
Q
L
R
D
G
-
T
L
D
F
A
L
T
A
A
H
K
H
-
D
-
I
D
T
D
L
E
A
Q
P
L
-
Y
V
S
D
V
V
I
V
G
Q
R
Q
H
P
M
--
A
N
-
A
--
T
R
L
A
E
L
Q
E
C
R
W
A
-
F
S
--
S
A
P
R
G
P
--
G
A
I
I
R
N
----
A
-
F
-
A
R
Y
-
G
L
-
P
E
P
K
L
G
L
V
C
E
--
S
F
L
A
L
-
P
G
V
-
V
A
H
S
D
L
L
T
T
M
P
R
T
L
Y
E
R
N
A
F
K
-
D
Q
L
C
S
-
I
P
L
Q
D
-
A
L
P
N
P
T
I
Y
V
L
R
R
H
D
L
P
V
T
P
A
A
A
G
L
I
R
W
I
Q
H
H
A
L
-----------
10
PsiBlast_PDB
77.84
27%
-95
- C3 -
3FXQ
6
TSAR_COMTE
A:
[2-237]
-----
L
K
L
Q
T
L
Q
A
L
I
C
I
E
E
V
G
S
L
R
A
A
A
Q
L
L
H
L
S
Q
P
A
L
S
A
A
I
Q
Q
L
E
D
E
L
K
A
P
L
L
V
R
T
K
R
G
V
S
L
T
S
F
G
Q
A
F
M
K
H
A
R
L
I
---
V
T
-
E
S
R
R
A
Q
E
E
I
G
Q
L
R
-
G
R
W
-------
E
G
H
I
T
F
A
A
S
P
A
I
A
L
A
A
L
P
L
A
L
A
S
F
A
R
E
F
P
D
V
T
V
N
V
R
D
G
M
Y
P
A
V
S
P
Q
L
R
D
G
-
T
L
D
F
A
L
T
A
A
H
K
H
-
D
-
I
D
T
D
L
E
A
Q
P
L
-
Y
V
S
D
V
V
I
V
G
Q
R
Q
H
P
M
--
A
N
-
A
--
T
R
L
A
E
L
Q
E
C
R
W
A
-
F
S
--
S
A
P
R
G
P
--
G
A
I
I
R
N
----
A
-
F
-
A
R
Y
-
G
L
-
P
E
P
K
L
G
L
V
C
E
--
S
F
L
A
L
-
P
G
V
-
V
A
H
S
D
L
L
T
T
M
P
R
T
L
Y
E
R
N
A
F
K
-
D
Q
L
C
S
-
I
P
L
Q
D
-
A
L
P
N
P
T
I
Y
V
L
R
R
H
D
L
P
V
T
P
A
A
A
G
L
I
R
W
I
Q
H
H
A
L
-----------
32
HHSearch
77.70
19%
-77
- C3 -
2ESN
-
?
A:
[8-303]
-----
L
D
L
N
L
L
L
V
F
D
A
L
Y
R
H
R
N
V
G
T
A
A
S
E
L
A
I
S
A
S
A
F
S
H
A
L
G
R
L
R
Q
G
L
D
D
E
L
F
L
R
Q
G
N
R
M
Q
P
T
Q
R
A
E
H
L
A
A
A
V
A
A
A
---
L
R
-
A
L
G
E
G
L
E
E
W
R
P
F
V
P
G
Q
S
-------
Q
R
T
F
V
F
A
A
T
D
Y
T
A
F
A
L
L
P
P
L
M
N
R
L
Q
H
S
A
P
G
V
R
L
R
L
V
N
A
E
R
K
L
S
V
E
A
L
A
S
G
-
R
I
D
F
A
L
G
Y
D
E
E
H
-
E
R
L
P
E
G
I
Q
A
H
D
W
-
F
A
D
R
Y
V
V
V
A
R
R
D
H
P
R
--
L
A
-
G
---
A
P
T
L
E
G
Y
L
A
E
R
-
H
A
--
V
V
T
P
W
N
--
E
--
D
S
G
V
I
D
-
R
-
L
L
A
R
S
G
L
--
R
R
E
V
A
-
V
Q
L
P
--
T
V
L
A
A
-
L
F
L
-
A
G
S
T
D
F
L
L
T
A
P
R
H
A
A
R
A
L
A
E
A
-
A
G
L
A
L
-
Y
P
A
P
F
-
D
I
-----
P
P
Y
V
L
R
L
Y
S
H
V
Q
--
G
R
D
A
H
A
W
M
I
G
Q
L
K
G
L
D
-------
52
Fugue
77.65
18%
-90
- C3 -
1IZ1
-
?
A:
[1-292]
-----
M
E
F
R
Q
L
K
Y
F
I
A
V
A
E
A
G
N
M
A
A
A
A
K
R
L
H
V
S
Q
P
P
I
T
R
Q
M
Q
A
L
E
A
D
L
G
V
V
L
L
E
R
S
H
R
G
I
E
L
T
A
A
G
H
A
F
L
E
D
A
R
R
I
---
L
E
-
L
A
G
R
S
G
D
R
S
R
A
A
A
-
R
G
D
-------
V
G
E
L
S
V
A
Y
F
G
T
P
I
Y
R
S
L
P
L
L
L
R
A
F
L
T
S
T
P
T
A
T
V
S
L
T
H
M
T
K
D
E
Q
V
E
G
L
L
A
G
-
T
I
H
V
G
F
S
--
R
F
F
-
P
-
R
H
P
G
I
E
I
V
N
I
-
A
Q
E
D
L
Y
L
A
V
H
R
S
Q
S
G
--
K
F
-
G
--
K
T
C
K
L
A
D
L
R
A
V
E
-
L
T
L
F
P
R
G
G
R
P
--
S
--
F
A
D
----
E
-
V
-
I
G
L
F
K
H
-
A
G
I
E
P
R
I
A
R
V
VE
D
A
T
A
A
-
L
A
L
-
T
M
A
G
A
A
S
S
I
V
P
-----
A
S
V
A
A
-
I
R
W
P
D
-
I
A
F
A
R
-
I
V
G
T
--
R
V
K
V
P
I
S
C
I
F
R
K
E
-
K
Q
P
P
I
L
A
R
F
V
E
H
V
R
R
S
A
-------
35
HHSearch
68.74
16%
-76
- C3 -
3SZP
-
?
A:
[1-290]
-----
M
K
L
D
D
L
N
L
F
R
L
V
V
E
N
G
S
Y
T
S
T
S
K
K
T
M
I
P
V
A
T
I
T
R
R
I
Q
A
L
E
D
S
L
N
L
R
L
L
N
R
H
A
R
K
L
T
L
T
E
A
G
E
R
F
Y
K
D
C
S
P
L
---
L
E
-
R
L
A
S
M
T
E
E
I
T
D
E
C
-
R
G
A
-------
S
G
R
I
R
I
S
A
P
S
N
L
T
K
R
M
M
M
P
M
F
N
A
F
M
E
K
Y
P
D
I
H
I
E
L
M
M
S
N
Q
---
A
D
D
L
D
P
T
-
E
W
D
V
I
F
R
V
G
P
Q
R
----
D
S
S
L
I
A
R
K
I
-
G
E
V
K
D
I
L
V
A
S
P
Q
Y
L
S
--
S
H
-
P
--
Q
P
T
H
A
E
E
L
H
Q
H
Q
-
L
L
--
K
G
Y
P
L
L
--
K
--
W
Q
L
T
---
N
S
Q
-
G
E
T
V
V
N
-
S
D
R
G
R
-
F
Q
A
S
--
A
L
N
V
V
-
R
S
A
-
C
S
E
G
L
G
I
T
L
M
P
D
V
M
L
R
E
F
L
E
D
-
G
S
L
V
Q
-
V
L
S
D
W
-
S
S
-----
N
P
R
D
I
Y
M
L
Y
N
H
K
D
H
Q
P
E
K
V
R
L
F
I
D
F
V
I
G
Y
H
L
------
21
PsiBlast_CBE
68.73
32%
-104
- C3 -
3K1N
2
BENM_ACIAD
B:
[1-189]
-----
M
E
L
R
H
L
R
Y
F
V
A
V
V
E
E
Q
S
F
T
K
A
A
D
K
L
C
I
A
Q
P
P
L
S
R
Q
I
Q
N
L
E
E
E
L
G
I
Q
L
L
E
R
G
S
R
P
V
K
T
T
P
E
G
H
F
F
Y
Q
Y
A
I
K
L
LSN
V
D
-
Q
M
V
S
M
T
K
R
I
A
S
V
E
-
K
T
I
RIGF---
V
G
S
L
L
F
G
--------
L
L
P
R
I
I
H
L
Y
R
Q
A
H
P
N
L
R
I
E
L
Y
E
M
G
T
K
A
Q
T
E
A
L
K
E
G
-
R
I
D
A
G
F
G
R
L
K
I
----
S
D
P
A
I
K
R
T
L
L
-
R
N
E
R
L
M
V
A
V
H
A
S
H
P
L
NQ
M
K
-
D
--
K
G
V
H
L
N
D
L
I
D
E
K
-
I
L
--
L
Y
P
S
S
P
--
K
--
P
N
F
----
S
-
T
-
H
V
M
N
I
F
-
S
D
H
G
L
E
P
T
K
I
--
N
E
V
R
E
-
V
Q
L
-
A
L
G
L
V
A
A
G
E
G
I
S
L
V
P
A
S
T
Q
S
I
-
Q
L
F
N
L
-
S
Y
V
P
L
-
L
D
P
D
A
I
T
P
I
Y
I
A
V
R
N
M
E
E
S
T
Y
I
Y
S
L
Y
E
T
I
R
Q
I
Y
A
Y
E
G
F
T
E
P
P
N
W
2
PsiBlast_PDB
68.31
30%
-103
- C3 -
3K1M
3
BENM_ACIAD
A:
[1-189]
-----
M
E
L
R
H
L
R
Y
F
V
A
V
V
E
E
Q
S
F
T
K
A
A
D
K
L
C
I
A
Q
P
P
L
S
R
Q
I
Q
N
L
E
E
E
L
G
I
Q
L
L
E
R
G
S
R
P
V
K
T
T
P
E
G
H
F
F
Y
Q
Y
A
I
K
L
---
L
S
-
N
V
D
Q
M
V
S
M
T
K
R
I
A
-
S
V
E
K
T
I
R
I
G
F
V
G
S
L
L
F
G
--------
L
L
P
R
I
I
H
L
Y
R
Q
A
H
P
N
L
R
I
E
L
Y
E
M
G
T
K
A
Q
T
E
A
L
K
E
G
-
R
I
D
A
G
F
G
R
L
K
I
----
S
D
P
A
I
K
H
T
L
L
-
R
N
E
R
L
M
V
A
V
H
A
S
H
P
L
NQ
M
K
-
D
--
K
G
V
H
L
N
D
L
I
D
E
K
-
I
L
--
L
Y
P
S
S
P
--
K
--
P
N
F
----
S
-
T
-
H
V
M
N
I
F
-
S
D
H
G
L
E
P
T
K
I
--
N
E
V
R
E
-
V
Q
L
-
A
L
G
L
V
A
A
G
E
G
I
S
L
V
P
A
S
T
Q
S
I
-
Q
L
F
N
L
-
S
Y
V
P
L
-
L
D
P
D
A
I
T
P
I
Y
I
A
V
R
N
M
E
E
S
T
Y
I
Y
S
L
Y
E
T
I
R
Q
I
Y
A
Y
E
G
F
T
E
----
9
PsiBlast_PDB
67.80
27%
-100
- C3 -
4X6G
4
?
A:
[7-190]
-----
M
T
L
T
E
L
R
Y
I
V
T
L
A
Q
E
Q
H
F
G
R
A
A
E
R
C
H
V
S
Q
P
T
L
S
V
G
V
K
K
L
E
D
E
L
G
V
L
I
F
E
R
S
K
S
A
V
R
L
T
P
V
G
E
G
I
V
A
Q
A
Q
K
V
---
L
E
--
Q
A
Q
G
I
R
E
L
A
Q
A
G
-
K
N
Q
L------
A
A
P
L
K
V
G
A
I
Y
T
I
G
P
Y
L
F
P
H
L
I
P
Q
L
H
R
V
A
P
Q
M
P
L
Y
I
E
-
E
N
F
T
H
I
L
R
D
K
L
R
T
G
E
L
D
A
I
I
I
A
L
P
F
Q
-
E
-
A
D
--
V
L
T
K
P
L
-
F
D
E
P
F
Y
V
L
M
P
A
D
H
P
W
--
T
A
-
K
--
A
S
I
D
S
E
L
L
N
D
K
S
-
L
L
--
L
L
G
E
G
H
--
D
--
F
R
D
----
Q
-
V
-
L
E
A
C
P
T
-
V
R
K
G
D
E
N
K
H
T
--
T
V
E
S
S
-
S
L
E
-
T
I
R
H
M
V
A
S
G
L
G
V
S
V
L
P
F
S
A
V
D
-
S
H
H
Y
A
-
P
G
V
I
E
-
V
R
P
F
S
A
P
V
P
F
R
T
V
A
I
A
W
R
A
S
F
P
R
P
R
A
I
E
V
L
A
D
S
I
R
L
C
S
------
5
PsiBlast_PDB
67.55
32%
-100
- C3 -
3K1N
2
BENM_ACIAD
A:
[1-189]
-----
M
E
L
R
H
L
R
Y
F
V
A
V
V
E
E
Q
S
F
T
K
A
A
D
K
L
C
I
A
Q
P
P
L
S
R
Q
I
Q
N
L
E
E
E
L
G
I
Q
L
L
E
R
G
S
R
P
V
K
T
T
P
E
G
H
F
F
Y
Q
Y
A
I
K
L
L
S
N
V
D
-
Q
M
V
S
M
T
K
R
I
A
S
V
E
-
K
T
I
R
I
G
F
---
V
G
S
L
L
F
G
--------
L
L
P
R
I
I
H
L
Y
R
Q
A
H
P
N
L
R
I
E
L
Y
E
M
G
T
K
A
Q
T
E
A
L
K
E
G
-
R
I
D
A
G
F
G
R
L
K
I
----
S
D
P
A
I
K
R
T
L
L
-
R
N
E
R
L
M
V
A
V
H
A
S
H
P
L
NQ
M
K
-
D
--
K
G
V
H
L
N
D
L
I
D
E
K
-
I
L
--
L
Y
P
S
S
P
--
K
--
P
N
F
----
S
-
T
-
H
V
M
N
I
F
-
S
D
H
G
L
E
P
T
K
I
--
N
E
V
R
E
-
V
Q
L
-
A
L
G
L
V
A
A
G
E
G
I
S
L
V
P
A
S
T
Q
S
I
-
Q
L
F
N
L
-
S
Y
V
P
L
-
L
D
P
D
A
I
T
P
I
Y
I
A
V
R
N
M
E
E
S
T
Y
I
Y
S
L
Y
E
T
I
R
Q
I
Y
A
Y
E
G
F
T
E
P
P
N
-
41
HHSearch
64.46
16%
-67
- C3 -
3ISP
-
Y1985_MYCTU
A:
[6-293]
-----
L
D
G
P
Q
L
A
A
L
A
A
V
V
E
L
G
S
F
D
A
A
A
E
R
L
H
V
T
P
S
A
V
S
Q
R
I
K
S
L
E
Q
Q
V
G
Q
V
L
V
V
R
E
-
K
P
C
R
A
T
T
A
G
I
P
L
L
R
L
A
A
Q
T
---
A
L
-
L
E
S
E
A
L
A
E
M
G
--
A
-
S
L
K
-------
R
T
R
I
T
I
A
V
N
A
D
S
M
A
T
W
F
S
A
V
F
D
----
G
L
G
D
V
L
L
D
V
R
I
E
D
Q
D
H
S
A
R
L
L
R
E
G
-
V
A
M
G
A
V
T
T
E
R
N
P
----
V
P
G
C
R
V
H
P
L
-
G
E
M
R
Y
L
P
V
A
S
R
P
F
V
Q
--
R
H
L
S
--
D
G
F
T
A
A
A
A
A
K
A
P
-
S
L
--
A
W
N
R
D
D
--
G
--
L
Q
D
M
L
V
R
K
-
A
F
R
R
A
I
T
----
R
P
T
-
H
F
V
P
--
T
T
E
G
F
-
T
A
A
-
A
R
A
G
L
G
W
G
M
F
P
E
K
L
A
A
S
P
L
A
D
-
G
S
F
V
R
-
V
C
--
D
-
I
-------
H
L
D
V
P
L
Y
W
Q
C
W
K
L
D
S
P
I
I
A
R
I
T
D
T
V
R
A
A
A
S
G
L
Y
R
G
Q
39
HHSearch
63.53
24%
-81
- C3 -
2H9B
5
BENM_ACIAD
A:
[89-297]
----------------------------------------------------------------------------------------------------------
E
K
T
I
R
I
G
F
V
G
S
L
L
F
G
L
L
P
R
I
I
H
L
Y
R
Q
A
H
P
N
L
R
I
E
L
Y
E
M
G
T
K
A
Q
T
E
A
L
K
E
G
-
R
I
D
A
G
F
G
R
L
K
I
S
----
D
P
A
I
K
H
S
L
L
-
R
N
E
R
L
M
V
A
V
H
A
S
H
P
L
--
N
Q
-
M
KD
K
G
V
H
L
N
D
L
I
D
E
K
-
I
L
--
L
Y
P
S
S
P
KP
N
--
F
S
T
H
V
M
-
N
-
I
F
S
D
H
G
L
--
E
P
T
K
I
-
N
E
V
R
--
E
V
Q
L
A
-
L
G
L
-
V
A
A
G
E
G
I
S
L
V
P
A
S
T
Q
S
I
Q
--
L
-
F
N
L
S
Y
-
V
P
L
L
D
-
P
D
-----
A
I
T
P
I
Y
I
A
V
R
N
M
E
-
E
S
T
Y
I
Y
S
L
Y
E
T
I
R
Q
I
Y
A
Y
E
G
F
T
E
49
HHSearch
63.51
20%
-84
- C3 -
2QL3
-
?
A:
[3-207]
--------------------------------------------------------------------------------------------------
V
-------
A
G
P
I
A
V
G
C
Y
P
A
L
G
P
T
I
L
P
S
M
L
Y
A
F
T
A
E
Y
P
R
A
S
V
E
F
R
E
D
T
Q
N
R
L
R
T
Q
L
E
G
G
-
E
L
D
V
A
I
V
Y
D
L
D
L
----
S
P
E
W
Q
T
V
P
L
-
M
T
R
E
P
M
V
V
L
G
A
E
H
P
L
--
A
G
-
V
D-
G
P
V
R
L
A
D
L
A
E
H
P
-
M
V
--
L
L
D
A
P
P
--
S
--
T
N
H
A
M
--
D
-
V
C
R
E
A
G
F
--
A
P
R
V
A
-
Y
R
T
A
--
N
F
E
T
A
-
R
A
F
-
V
G
R
G
L
G
W
T
L
L
L
Q
R
P
R
V
D
V
T
Y
E
G
L
P
V
V
V
-
K
P
I
A
E
-
P
K
----
P
A
S
V
A
V
V
V
A
W
H
Q
E
A
T
L
S
R
V
A
R
A
F
I
R
F
V
T
A
---------
1
PsiBlast_PDB
63.49
32%
-86
- C3 -
3K1P
-
BENM_ACIAD
A:
[1-189]
-----
M
E
L
R
H
L
R
Y
F
V
A
V
V
E
E
Q
S
F
T
K
A
A
D
K
L
C
I
A
Q
P
P
L
S
R
Q
I
Q
N
L
E
E
E
L
G
I
Q
L
L
E
R
G
S
R
P
V
K
T
T
P
E
G
H
F
F
Y
Q
Y
A
I
K
L
L
S
N
V
D
-
Q
M
V
S
M
T
K
R
I
A
S
V
E
-
K
T
I
R
I
G
F
---
V
G
S
L
L
F
G
--------
L
L
P
R
I
I
H
L
Y
R
Q
A
H
P
N
L
R
I
E
L
Y
E
M
G
T
K
A
Q
T
E
A
L
K
E
G
-
R
I
D
A
G
F
G
R
L
K
I
----
S
D
P
A
I
K
R
T
L
L
-
R
N
E
R
L
M
V
A
V
H
A
S
H
P
L
N
Q
M
K
-
D
--
K
G
V
H
L
N
D
L
I
D
E
K
-
I
L
--
L
Y
P
S
S
P
--
K
--
P
N
F
----
S
-
T
-
H
V
M
N
I
F
-
S
D
H
G
L
E
P
T
K
I
--
N
E
V
R
K
-
V
Q
L
-
A
L
G
L
V
A
A
G
E
G
I
S
L
V
P
A
S
T
Q
S
I
-
Q
L
F
N
L
-
S
Y
V
P
L
-
L
D
P
D
A
I
T
P
I
Y
I
A
V
R
N
M
E
E
S
T
Y
I
Y
S
L
Y
E
T
I
R
Q
I
Y
A
Y
E
G
F
T
E
P
P
N
-
37
HHSearch
63.43
21%
-80
- C3 -
1AL3
1
CYSB_KLEPN
A:
[88-297]
----------------------------------------------------------------------------------------------
T
-
W
P
D
-------
K
G
S
L
Y
V
A
T
T
H
T
Q
A
R
Y
A
L
P
G
V
I
K
G
F
I
E
R
Y
P
R
V
S
L
H
M
H
Q
G
S
P
T
Q
I
A
E
A
V
S
K
G
-
N
A
D
F
A
I
A
T
E
A
L
H
-
L
--
Y
D
D
L
V
M
L
P
C
-
Y
H
W
N
R
S
I
V
V
T
P
E
H
P
L
--
A
T
-
K
--
G
S
V
S
I
E
E
L
A
Q
Y
P
-
L
V
--
T
Y
T
F
G
F
--
T
--
G
R
S
E
L
D
-
T
-
A
F
N
R
A
G
L
--
T
P
R
I
V
-
F
T
A
T
--
D
A
D
V
I
-
K
T
Y
-
V
R
L
G
L
G
V
G
V
I
A
S
M
A
V
D
P
-
V
S
D
-
P
D
L
V
K
-
L
D
A
N
G
-
I
F
-----
S
H
S
T
T
K
I
G
F
R
R
S
T
F
L
R
S
Y
M
Y
D
F
I
Q
R
F
A
P
H
L
T
R
D
V
V
D
T