@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0195: (2015-12-25 )
MQIGVPLETHAGETRVSATPETVKKLIGQGHQVIVQSGAGVSASQPDSAYEAAGATIGSAAEAFGADLVLKVVAPSAAELAQMKSGAVLVGMLNPFDNENIARMAERGITAFALEAAPRTSRAQSLDVLSSQANIAGYKAVMLAANHYPRFMPMLMTAAGTVKAARVLILGAGVAGLQAIATAKRLGAVIEASDVRPAVKEQIESLGAKFVDVPYETDEERECAEGVGGYARPMPASWMERQAKAVHERAKQSDIVITTALIPGRKAPTLLHEATVAEMKPGSVVIDLAAAQGGNCPLTEADQVVVRHGVTIVGHSNLAALVPADASALYARNILDFLKLTLNAEGFSVNLEDDIVAACLMCRDGQAVRKNG
Atome Classification :
(21 SA)
.........10........20........30........40........50........-60...-.-....70........-----80........90........100.-......110.......120.......130.......140.......150.......160.......170.......180.......190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.......310.......320.......330......--.340.......350.......360.......370
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MQIGVPLETHAGETRVSA
T
P
E
T
V
K
K
L
IGQG
H
Q
V
I
V
QSGAGVSASQPD
S
A
Y
E
A
AGATI
G
S
-
A
A
E
A
F-
G
-
A
D
L
V
L
K
VVAP
S
A
A
E
-----
L
A
Q
MKSG
A
V
L
V
G
MLNPFD
N
E
N
I
A
R
-
M
A
E
RG
I
T
A
F
A
LEAAPRTSRA
Q
S
L
D
V
L
SSQANIA
G
Y
K
A
V
M
L
AANHY
P
R
F
M
P
M
L
M
TAAGT
V
K
A
A
R
V
L
I
L
GA
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
I
E
A
S
DV
R
P
A
V
K
E
Q
I
E
S
L
G
A
K
F
VDVPYET
D
E
E
R
E
C
A
EGVGGYARPM
P
A
S
W
M
E
R
Q
A
K
A
V
H
E
R
AKQS
D
I
V
I
T
T
ALIPGRKAP
T
L
L
H
EA
T
V
AEMKP
G
S
V
V
I
D
L
AAAQGGNCPLTEA
D
Q
V
V
VRH
G
V
T
I
VGHSN
L
A
A
LVPA
D
A
S
A
L
Y
A
R
N
I
L
D
F
L
--
K
L
TLNAEG
F
S
V
NL
E
D
D
I
V
A
A
C
L
MCRDG
Q
A
VRKNG
32
PsiBlast_CBE
95.22
52%
-113
- C3 -
1L7E
1
PNTAA_RHORT
D:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
A
S
T
A
A
Q
A
L
-
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
---
D
----------
G
G
Y
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
K
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
TP
H
V
D
K
D
T
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
D
G
A
I
V
H
P
--
35
PsiBlast_CBE
94.79
52%
-113
- C3 -
2FSV
3
PNTAA_RHORT
B:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
A
S
T
A
A
Q
A
L
-
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
N
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
---
D
-------------------
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
K
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
TP
H
V
D
K
D
T
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
D
G
A
I
V
H
P
A
L
12
PsiBlast_PDB
94.78
52%
-116
- C3 -
2FSV
2
PNTAA_RHORT
A:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
A
S
T
A
A
Q
A
L
-
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
N
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
---------------
G
Y
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
K
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
TP
H
V
D
K
D
T
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
D
G
A
I
V
H
P
A
-
9
PsiBlast_PDB
94.69
52%
-108
- C3 -
2OO5
5
PNTAA_RHORT
A:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
A
S
T
A
A
Q
A
L
-
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
---
D
D
E
A
M
K
T
A
E
T
A
G
G
Y
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
K
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
TP
H
V
D
K
D
T
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
D
G
A
I
V
H
P
A
L
13
PsiBlast_PDB
94.57
52%
-116
- C3 -
1NM5
1
PNTAA_RHORT
A:
[1-374]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
A
S
T
A
A
Q
A
L
-
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
N
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
-----------------
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
K
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
TP
H
V
D
K
D
T
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
D
G
A
I
-----
7
PsiBlast_PDB
94.46
52%
-108
- C3 -
1U2G
1
PNTAA_RHORT
A:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
A
S
T
A
A
Q
A
L
-
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
---
D
D
E
A
M
K
T
A
E
T
A
G
G
Y
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
K
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
TP
H
V
D
K
D
T
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
D
G
A
I
V
H
P
A
-
4
PsiBlast_PDB
94.43
52%
-111
- C3 -
1L7E
1
PNTAA_RHORT
A:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
A
S
T
A
A
Q
A
L
-
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
---
D
D
------
E
T
A
G
G
Y
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
K
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
TP
H
V
D
K
D
T
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
D
G
A
I
V
H
P
A
-
6
PsiBlast_PDB
94.39
52%
-105
- C3 -
1U2D
1
PNTAA_RHORT
A:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
A
S
T
A
A
Q
A
L
-
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
---
D
D
E
A
M
K
T
A
E
T
A
G
G
Y
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
K
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
TP
H
V
D
K
D
T
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
D
G
A
I
V
H
P
A
-
10
PsiBlast_PDB
94.21
52%
-105
- C3 -
2OOR
1
PNTAA_RHORT
A:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
A
S
T
A
A
Q
A
L
-
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
---
D
D
E
A
M
K
T
A
E
T
A
G
G
Y
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
K
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
TP
H
V
D
K
D
T
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
D
G
A
I
V
H
P
A
-
3
PsiBlast_PDB
94.10
52%
-111
- C3 -
1L7D
-
PNTAA_RHORT
A:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
A
S
T
A
A
Q
A
L
-
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
--------------------------
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
K
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
TP
H
V
D
K
D
T
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
D
G
A
I
V
H
P
--
34
PsiBlast_CBE
94.02
52%
-113
- C3 -
2FRD
2
PNTAA_RHORT
B:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
A
S
T
A
A
Q
A
L
-
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
D
I
L
A
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
---
D
D
------------------
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
K
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
TP
H
V
D
K
D
T
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
D
G
A
I
V
H
P
A
L
23
PsiBlast_CBE
93.96
52%
-106
- C3 -
2OO5
6
PNTAA_RHORT
B:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
A
S
T
A
A
Q
A
L
-
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
---
D
D
E
A
M
K
T
A
E
T
A
G
G
Y
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
K
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
TP
H
V
D
K
D
T
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
D
G
A
I
V
H
P
A
L
11
PsiBlast_PDB
93.85
52%
-112
- C3 -
2FRD
1
PNTAA_RHORT
A:
[1-370]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
A
S
T
A
A
Q
A
L
-
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
D
I
L
A
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
-------------
A
G
G
Y
A
K
E
M
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
K
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
TP
H
V
D
K
D
T
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
---------
21
PsiBlast_CBE
93.81
52%
-113
- C3 -
1PTJ
3
PNTAA_RHORT
B:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
A
S
T
A
A
Q
A
L
-
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
---
D
D
E
A
M
---------------
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
K
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
TP
H
V
D
K
D
T
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
D
G
A
I
V
H
P
A
L
31
PsiBlast_CBE
93.79
52%
-113
- C3 -
1U28
4
PNTAA_RHORT
B:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
A
S
T
A
A
Q
A
L
-
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
---
D
---------------------
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
K
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
TP
H
V
D
K
D
-
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
D
G
A
I
V
H
P
A
L
22
PsiBlast_CBE
93.79
52%
-110
- C3 -
2OOR
3
PNTAA_RHORT
B:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
A
S
T
A
A
Q
A
L
-
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
---
D
-----------------
G
E
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
K
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
TP
H
V
D
K
D
T
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
D
G
A
I
V
H
P
A
L
14
PsiBlast_PDB
93.70
52%
-110
- C3 -
2FR8
1
PNTAA_RHORT
A:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
A
S
T
A
A
Q
A
L
-
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
A
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
----------------------------
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
K
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
TP
H
V
D
K
D
T
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
D
G
A
I
V
H
P
A
L
36
PsiBlast_CBE
93.62
52%
-112
- C3 -
1NM5
3
PNTAA_RHORT
B:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
A
S
T
A
A
Q
A
L
-
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
N
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
-----------------------
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
K
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
TP
H
V
D
K
D
T
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
D
G
A
I
V
H
P
A
-
37
PsiBlast_CBE
93.60
52%
-108
- C3 -
2FR8
1
PNTAA_RHORT
B:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
A
S
T
A
A
Q
A
L
-
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
A
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
---------------------------
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
K
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
TP
H
V
D
K
D
T
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
D
G
A
I
V
----
33
PsiBlast_CBE
93.55
52%
-109
- C3 -
1HZZ
1
PNTAA_RHORT
B:
[1-375]
M
K
I
A
I
P
K
E
R
R
P
G
E
D
R
V
A
I
S
P
E
V
V
K
K
L
V
G
L
G
F
E
V
I
V
E
Q
G
A
G
V
G
A
S
I
T
D
D
A
L
T
A
A
G
A
T
I
A
S
T
A
A
Q
A
L
-
S
Q
A
D
V
V
W
K
V
Q
R
P
M
T
A
E
EGTDE
V
A
L
I
K
E
G
A
V
L
M
C
H
L
G
A
L
T
N
R
P
V
V
E
A
L
T
K
R
K
I
T
A
Y
A
M
E
L
M
P
R
I
S
R
A
Q
S
M
D
I
L
S
S
Q
S
N
L
A
G
Y
R
A
V
I
D
G
A
Y
E
F
A
R
A
F
P
M
M
M
T
A
A
G
T
V
P
P
A
R
V
L
V
F
G
V
G
V
A
G
L
Q
A
I
A
T
A
K
R
L
G
A
V
V
M
A
T
D
V
R
A
A
T
K
E
Q
V
E
S
L
G
G
K
F
I
T
V
---
D
D
E
A
M
---------------
E
F
R
K
K
Q
A
E
A
V
L
K
E
L
V
K
T
D
I
A
I
T
T
A
L
I
P
G
K
P
A
P
V
L
I
T
E
E
M
V
T
K
M
K
P
G
S
V
I
I
D
L
A
V
E
A
G
G
N
C
P
L
S
E
P
G
K
I
V
V
K
H
G
V
K
I
V
G
H
T
N
V
P
S
R
V
A
A
D
A
S
P
L
F
A
K
N
L
L
N
F
L
TP
H
V
D
K
D
T
K
T
L
V
M
K
L
E
D
E
T
V
S
G
T
C
V
T
R
D
G
A
I
V
H
P
A
L
50
PsiBlast_CBE
85.94
43%
-113
- C3 -
4IZH
9
?
A:
[10-370]
--
V
A
V
P
K
E
R
A
P
G
E
R
R
V
A
L
V
P
E
V
V
A
R
L
V
K
G
G
A
R
V
R
V
E
R
G
A
G
E
G
A
Y
H
P
D
E
A
Y
Q
E
A
G
A
E
V
V
E
-
R
G
E
L
L
K
G
-
A
H
L
L
F
T
V
Q
P
P
P
E
D
L
-----
I
Q
A
L
E
P
G
A
I
V
V
G
F
V
Q
P
H
K
N
L
E
L
V
R
A
L
Q
A
K
K
A
T
V
I
A
M
E
L
I
P
R
I
T
R
A
Q
S
M
D
A
L
S
S
Q
A
T
V
A
G
Y
L
A
A
I
H
A
A
R
L
S
P
R
F
F
P
M
L
T
T
A
A
G
T
I
R
P
A
K
V
M
V
M
G
V
G
V
A
G
L
M
A
I
A
T
A
K
R
L
G
A
Q
V
F
A
Y
D
V
R
K
A
A
L
E
Q
A
L
S
L
G
A
K
P
I
E
L
P
I
-------
S
A
--------
E
L
T
E
E
E
K
R
I
Q
H
E
A
L
R
D
H
V
A
G
M
D
V
L
I
T
T
A
Q
V
P
G
R
R
A
P
I
L
L
T
E
D
M
V
E
R
L
K
P
G
T
V
V
V
D
L
A
A
E
S
G
G
N
C
V
L
T
K
P
G
E
V
V
E
V
R
G
V
R
V
Y
G
P
L
N
L
P
S
E
L
S
V
H
A
S
E
M
Y
A
K
N
L
Y
N
L
S
--
S
L
L
I
E
K
G
A
F
A
P
K
W
E
D
E
I
V
R
A
A
L
L
M
K
E
G
E
V
L
H
G
P
T