@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0196: (2015-12-25 )
MSMNLVTLLYLIASVCFIQALKGLSHPTTSRRGNLFGMVGMAIAVATTVGLVFKLGAEIATTGVGYIVVGLLVGGTAGSIMAKRVEMTKMPELVAFMHSMIGLAAVFIAIAAVVEPQSLGIVAHLGDTIPTGNRLELFLGAAIGAITFSGSVIAFGKLSGKYKFRLFQGTPVQFSGQHLLNLVLGLATLGLGLVFMFTGNLTAFAVMLALAFVLGVLIIIPIGGADMPVVVSMLNSYSGWAAAGIGFSLNNSMLIIAGSLVGSSGAILSYIMCKAMNRSFFNVILGGFGAEADAGGPAGSKEQRPVKSGSADDASFLLTNADSVIIVPGYGLAVARAQHALMELAEKLTHRGVTVKFAIHPVAGRMPGHMNVLLAEAEVPYEQVFEMEDINSEFGQTDVVLVLGANDVVNPAAKNDPKSPIAGMPILEAYKAKTVIVNKRSMASGYAGLDNELFYLDKTMMVFGDAKKVIEDMVKAVE
Atome Classification :
(34 SA)
.........10........20........30........40........50........60........70........80........90........100.......110.......120.......130.......140.......150.......160.......170.......180........190.......200.......210.......220.......230.......240.......250.......260.......270.......280.......290.......300.....-..310----........320.......330.......340.......350.......360.......370.......380.......390.......400.......410.......420.......430.......440.......450.......460.......470......--
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MS
M
N
L
V
T
L
L
Y
L
I
A
S
V
C
F
I
Q
A
L
K
GLSHPTTSRRGN
L
F
G
M
V
G
M
A
I
A
V
A
T
T
V
G
L
V
F
KLG
A
E
I
A
TT
G
V
G
Y
I
V
V
G
L
L
VGGT
A
G
S
I
M
A
K
R
V
E
M
TK
M
P
E
L
V
A
F
M
H
S
M
I
G
L
A
A
V
F
I
A
I
A
A
VVEPQS
L
G
I
V
A
HLGDTIPTG
N
R
L
E
L
F
L
GA
A
I
G
A
I
T
FS
G
S
V
I
A
F
G
KLS
G
K
Y
K
F
R
LFQGTPVQFS
G
Q
H
L
L
N
-
L
V
L
G
L
A
T
L
G
L
G
L
V
F
M
FTG
N
L
T
A
F
A
V
M
L
A
L
A
F
V
L
G
V
L
I
I
I
PIGGA
D
M
P
V
V
V
S
M
L
NSYSGW
A
A
AGIGFSLNN
S
M
L
I
I
A
G
SLVGS
S
G
A
I
L
S
Y
I
M
C
K
A
M
N
R
S
F
F
N
V
I
L
GGFGAEADAGGPAGSKEQRPVK-SGSA-----DD
A
S
F
L
L
TNAD
S
V
I
I
VPGY
G
L
A
V
A
R
A
Q
H
A
L
M
E
L
A
E
K
L
THRG
V
T
V
K
F
A
I
HPVAGRMPGH
M
N
V
L
L
AEAEV
P
Y
E
Q
V
F
E
M
E
D
I
N
S
EFGQT
D
V
V
L
V
LGANDVVNPAAKNDPKSPIAGM
P
I
L
E
AYK
A
K
T
V
I
V
NKRSMASGYAGLDN
E
L
F
Y
LD
K
T
M
M
V
FG
D
A
K
K
V
I
E
D
M
V
K
AVE--
1
PsiBlast_PDB
86.90
43%
-141
- C6 -
4O9U
1
?
B:
[1-448]
--
M
D
L
I
Q
A
A
Y
F
V
V
A
I
L
F
I
V
G
L
K
R
M
A
H
P
T
T
A
K
S
G
I
V
W
A
G
W
G
M
V
L
A
V
L
A
T
F
---
F
W
P
G
M
G
N
F
A
L
I
L
L
A
L
L
L
G
S
V
V
A
W
W
A
----
A
V
R
V
A
M
T
D
M
P
Q
M
V
A
I
Y
N
G
M
G
G
G
A
A
A
T
I
A
A
V
E
L
L
K
----------
G
A
F
E
N
T
G
L
M
A
L
A
I
L
G
G
L
I
G
S
V
A
F
T
G
S
L
I
A
F
A
K
L
Q
G
I
M
K
S
R
-----
P
I
L
F
P
G
Q
K
A
V
N
A
L
V
L
A
L
-
T
V
V
I
G
L
S
L
L
W
N
D
A
T
A
S
I
V
L
F
F
L
L
A
L
L
F
G
V
L
M
T
L
P
I
G
G
G
D
M
P
V
A
I
S
F
Y
N
A
F
T
G
M
A
V
G
F
E
G
F
A
V
G
N
P
A
L
M
V
A
G
T
L
V
G
A
A
G
T
L
L
T
V
L
M
A
R
A
M
N
R
S
V
W
S
V
L
V
G
G
----------
K
G
S
-----
L
K
-
P
I
D
V
-----
E
D
A
A
V
M
L
A
Y
A
G
K
V
V
F
V
P
G
Y
G
M
A
L
S
Q
A
Q
H
K
L
K
E
L
A
D
L
L
E
A
R
G
V
E
V
K
F
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
G
V
D
Y
D
K
L
K
D
L
E
E
I
N
P
E
F
P
T
V
D
V
A
V
V
I
G
A
N
D
V
V
N
P
A
A
R
R
-
P
G
S
P
L
Y
G
M
P
I
L
D
V
D
K
A
K
N
V
I
V
I
K
R
G
Q
G
K
G
F
A
G
V
E
N
E
L
F
Y
A
E
N
T
R
M
L
Y
G
D
A
Q
K
V
L
T
E
L
I
Q
A
L
K
--
50
HHSearch
74.53
64%
-113
- C6 -
1PNO
1
PNTB_RHORT
A:
[3-180]
-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
H
I
E
G
R
H
M
-
A
G
S
A
-----
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
--
13
PsiBlast_PDB
74.17
67%
-120
- C6 -
1PNO
1
PNTB_RHORT
A:
[10-179]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
S
A
-----
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
--
48
HHSearch
74.06
65%
-117
- C6 -
2FSV
1
C:
[30-203]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
-
A
G
S
A
-----
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
W
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
--
11
PsiBlast_PDB
73.87
67%
-119
- C6 -
2OO5
2
C:
[2-173]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
-
A
G
S
A
-----
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
--
14
PsiBlast_PDB
73.70
67%
-116
- C6 -
1PNQ
1
PNTB_RHORT
A:
[10-179]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
S
A
-----
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
--
8
PsiBlast_PDB
73.61
65%
-117
- C6 -
2FR8
1
C:
[30-202]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
-
A
G
S
A
-----
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
--
2
PsiBlast_PDB
73.50
65%
-118
- C6 -
2FSV
1
C:
[30-202]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
-
A
G
S
A
-----
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
W
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
--
5
PsiBlast_PDB
73.35
65%
-122
- C6 -
1U28
1
C:
[30-202]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
-
A
G
S
A
-----
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
--
7
PsiBlast_PDB
73.25
65%
-118
- C6 -
1U2G
2
C:
[30-202]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
-
A
G
S
A
-----
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
--
21
PsiBlast_CBE
73.10
67%
-121
- C6 -
1PNQ
2
B:
[10-179]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
S
A
-----
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
--
22
PsiBlast_CBE
72.81
67%
-119
- C6 -
1PNO
2
B:
[10-179]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
S
A
-----
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
--
9
PsiBlast_PDB
72.50
65%
-114
- C6 -
2FRD
2
C:
[30-202]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
-
A
G
S
A
-----
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
--
10
PsiBlast_PDB
72.45
67%
-118
- C6 -
1PTJ
1
C:
[2-173]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
-
A
G
S
A
-----
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
--
24
PsiBlast_CBE
72.24
67%
-120
- C6 -
1XLT
1
PNTB_RHORT
F:
[4-173]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
S
A
-----
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
--
47
HHSearch
72.14
52%
-110
* C6 *
1DJL
3
NNTM_HUMAN
A:
[23-202]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
E
I
S
G
T
H
T
-
E
I
N
L
-----
D
N
A
I
D
M
I
R
E
A
N
S
I
I
I
T
P
G
Y
G
L
C
A
A
K
A
Q
Y
P
I
A
D
L
V
K
M
L
T
E
Q
G
K
K
V
R
F
G
I
H
P
V
A
G
R
M
P
G
Q
L
N
V
L
L
A
E
A
G
V
P
Y
D
I
V
L
E
M
D
E
I
N
H
D
F
P
D
T
D
L
V
L
V
I
G
A
N
D
T
V
N
S
A
A
Q
E
D
P
N
S
I
I
A
G
M
P
V
L
E
V
W
K
S
K
Q
V
I
V
M
K
R
S
L
G
V
G
Y
A
A
V
D
N
P
I
F
Y
K
P
N
T
A
M
L
L
G
D
A
K
K
T
C
D
A
L
Q
A
K
V
R
--
12
PsiBlast_PDB
72.10
67%
-117
- C6 -
2OOR
1
C:
[2-173]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
V
K
-
A
G
S
A
-----
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
---
23
PsiBlast_CBE
71.96
67%
-119
- C6 -
1XLT
2
I:
[4-173]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
S
A
-----
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
--
6
PsiBlast_PDB
71.68
65%
-116
- C6 -
1U2D
2
C:
[30-202]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
-
A
G
S
A
-----
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
--
15
PsiBlast_PDB
71.43
67%
-117
- C6 -
1XLT
2
PNTB_RHORT
C:
[4-173]
---------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
G
S
A
-----
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
--
69
Fugue
71.41
52%
-109
- C6 -
1D4O
1
A:
[5-181]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
H
T
-
E
I
N
L
-----
D
N
A
I
D
M
I
R
E
A
N
S
I
I
I
T
P
G
Y
G
L
C
A
A
K
A
Q
Y
P
I
A
D
L
V
K
M
L
S
E
Q
G
K
K
V
R
F
G
I
H
P
V
A
G
R
M
P
G
Q
L
N
V
L
L
A
E
A
G
V
P
Y
D
I
V
L
E
M
D
E
I
N
H
D
F
P
D
T
D
L
V
L
V
I
G
A
N
D
T
V
N
S
A
A
Q
E
D
P
N
S
I
I
A
G
M
P
V
L
E
V
W
K
S
K
Q
V
I
V
M
K
R
S
L
G
V
G
Y
A
A
V
D
N
P
I
F
Y
K
P
N
T
A
M
L
L
G
D
A
K
K
T
C
D
A
L
Q
A
K
V
R
E
S
4
PsiBlast_PDB
71.38
65%
-116
- C6 -
1NM5
1
C:
[30-202]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
-
A
G
S
A
-----
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
--
49
HHSearch
71.19
51%
-109
- C6 -
1D4O
1
A:
[5-179]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
G
T
H
T
-
E
I
N
L
-----
D
N
A
I
D
M
I
R
E
A
N
S
I
I
I
T
P
G
Y
G
L
C
A
A
K
A
Q
Y
P
I
A
D
L
V
K
M
L
S
E
Q
G
K
K
V
R
F
G
I
H
P
V
A
G
R
M
P
G
Q
L
N
V
L
L
A
E
A
G
V
P
Y
D
I
V
L
E
M
D
E
I
N
H
D
F
P
D
T
D
L
V
L
V
I
G
A
N
D
T
V
N
S
A
A
Q
E
D
P
N
S
I
I
A
G
M
P
V
L
E
V
W
K
S
K
Q
V
I
V
M
K
R
S
L
G
V
G
Y
A
A
V
D
N
P
I
F
Y
K
P
N
T
A
M
L
L
G
D
A
K
K
T
C
D
A
L
Q
A
K
V
R
--
3
PsiBlast_PDB
71.07
65%
-119
- C6 -
1HZZ
1
C:
[30-202]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
S
V
K
-
A
G
S
A
-----
E
D
A
A
F
I
M
K
N
A
S
K
V
I
I
V
P
G
Y
G
M
A
V
A
Q
A
Q
H
A
L
R
E
M
A
D
V
L
K
K
E
G
V
E
V
S
Y
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
N
V
P
Y
D
E
V
F
E
L
E
E
I
N
S
S
F
Q
T
A
D
V
A
F
V
I
G
A
N
D
V
T
N
P
A
A
K
T
D
P
S
S
P
I
Y
G
M
P
I
L
D
V
E
K
A
G
T
V
L
F
I
K
R
S
M
A
S
G
Y
A
G
V
E
N
E
L
F
F
R
N
N
T
M
M
L
F
G
D
A
K
K
M
T
E
Q
I
V
Q
A
M
N
--
18
PsiBlast_PDB
70.18
53%
-113
- C6 -
1PT9
3
NNTM_HUMAN
A:
[23-195]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
E
I
S
G
T
H
T
E
I
N
L
D
N
A
I
D
M
I
R
E
A
N
S
I
I
I
T
P
G
Y
G
L
C
A
A
K
A
Q
Y
P
I
A
D
L
V
K
M
L
T
E
Q
G
K
K
V
R
F
G
I
H
P
V
A
G
R
M
P
G
Q
L
N
V
L
L
A
E
A
G
V
P
Y
D
I
V
L
E
M
D
E
I
N
H
D
F
P
D
T
D
L
V
L
V
I
G
A
N
D
T
V
N
S
A
A
Q
E
D
P
N
S
I
I
A
G
M
P
V
L
E
V
W
K
S
K
Q
V
I
V
M
K
R
S
L
G
V
G
Y
A
A
V
D
N
P
I
F
Y
K
P
N
T
A
M
L
L
G
D
A
K
K
T
C
D
A
L
Q
A
K
V
R
--
19
PsiBlast_PDB
69.95
53%
-112
- C6 -
1U31
3
NNTM_HUMAN
A:
[23-195]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
E
I
S
G
T
H
T
E
I
N
L
D
N
A
I
D
M
I
R
E
A
N
S
I
I
I
T
P
G
Y
G
L
C
A
A
K
A
Q
Y
P
I
A
D
L
V
K
M
L
T
E
Q
G
K
K
V
R
F
G
I
H
P
V
A
G
R
M
P
G
Q
L
N
V
L
L
A
E
A
G
V
P
Y
D
I
V
L
E
M
D
E
I
N
H
D
F
P
D
T
D
L
V
L
V
I
G
A
N
D
T
V
N
S
A
A
Q
E
D
P
N
S
I
I
A
G
M
P
V
L
E
V
W
K
S
K
Q
V
I
V
M
K
R
S
L
G
V
G
Y
A
A
V
D
N
P
I
F
Y
K
P
N
T
A
M
L
L
G
D
A
K
K
T
C
D
A
L
Q
A
K
V
R
--
17
PsiBlast_PDB
69.88
53%
-114
- C6 -
1DJL
3
NNTM_HUMAN
A:
[23-195]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
E
I
S
G
T
H
T
E
I
N
L
D
N
A
I
D
M
I
R
E
A
N
S
I
I
I
T
P
G
Y
G
L
C
A
A
K
A
Q
Y
P
I
A
D
L
V
K
M
L
T
E
Q
G
K
K
V
R
F
G
I
H
P
V
A
G
R
M
P
G
Q
L
N
V
L
L
A
E
A
G
V
P
Y
D
I
V
L
E
M
D
E
I
N
H
D
F
P
D
T
D
L
V
L
V
I
G
A
N
D
T
V
N
S
A
A
Q
E
D
P
N
S
I
I
A
G
M
P
V
L
E
V
W
K
S
K
Q
V
I
V
M
K
R
S
L
G
V
G
Y
A
A
V
D
N
P
I
F
Y
K
P
N
T
A
M
L
L
G
D
A
K
K
T
C
D
A
L
Q
A
K
V
R
--
20
PsiBlast_PDB
69.68
54%
-113
- C6 -
4J16
3
?
C:
[9-183]
----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
K
G
S
-----
L
K
-
P
I
D
V
-----
E
D
A
A
V
M
L
A
Y
A
G
K
V
V
F
V
P
G
Y
G
M
A
L
S
Q
A
Q
H
K
L
K
E
L
A
D
L
L
E
A
R
G
V
E
V
K
F
A
I
H
P
V
A
G
R
M
P
G
H
M
N
V
L
L
A
E
A
G
V
D
Y
D
K
L
K
D
L
E
E
I
N
P
E
F
P
T
V
D
V
A
V
V
I
G
A
N
D
V
V
N
P
A
A
R
R
-
P
G
S
P
L
Y
G
M
P
I
L
D
V
D
K
A
K
N
V
I
V
I
K
R
G
Q
G
K
G
F
A
G
V
E
N
E
L
F
Y
A
E
N
T
R
M
L
Y
G
D
A
Q
K
V
L
T
E
L
I
Q
A
L
K
--
25
PsiBlast_CBE
69.61
53%
-115
- C6 -
1U31
3
B:
[23-195]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
E
I
S
G
T
H
TEINL
D
N
A
I
D
M
I
R
E
A
N
S
I
I
I
T
P
G
Y
G
L
C
A
A
K
A
Q
Y
P
I
A
D
L
V
K
M
L
T
E
Q
G
K
K
V
R
F
G
I
H
P
V
A
G
R
M
P
G
Q
L
N
V
L
L
A
E
A
G
V
P
Y
D
I
V
L
E
M
D
E
I
N
H
D
F
P
D
T
D
L
V
L
V
I
G
A
N
D
T
V
N
S
A
A
Q
E
D
P
N
S
I
I
A
G
M
P
V
L
E
V
W
K
S
K
Q
V
I
V
M
K
R
S
L
G
V
G
Y
A
A
V
D
N
P
I
F
Y
K
P
N
T
A
M
L
L
G
D
A
K
K
T
C
D
A
L
Q
A
K
V
R
--
27
PsiBlast_CBE
69.42
53%
-116
- C6 -
1DJL
3
B:
[23-195]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
E
I
S
G
T
H
TEINL
D
N
A
I
D
M
I
R
E
A
N
S
I
I
I
T
P
G
Y
G
L
C
A
A
K
A
Q
Y
P
I
A
D
L
V
K
M
L
T
E
Q
G
K
K
V
R
F
G
I
H
P
V
A
G
R
M
P
G
Q
L
N
V
L
L
A
E
A
G
V
P
Y
D
I
V
L
E
M
D
E
I
N
H
D
F
P
D
T
D
L
V
L
V
I
G
A
N
D
T
V
N
S
A
A
Q
E
D
P
N
S
I
I
A
G
M
P
V
L
E
V
W
K
S
K
Q
V
I
V
M
K
R
S
L
G
V
G
Y
A
A
V
D
N
P
I
F
Y
K
P
N
T
A
M
L
L
G
D
A
K
K
T
C
D
A
L
Q
A
K
V
R
--
26
PsiBlast_CBE
68.83
53%
-113
- C6 -
1PT9
3
B:
[23-195]
-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
P
M
E
I
S
G
T
H
TEINL
D
N
A
I
D
M
I
R
E
A
N
S
I
I
I
T
P
G
Y
G
L
C
A
A
K
A
Q
Y
P
I
A
D
L
V
K
M
L
T
E
Q
G
K
K
V
R
F
G
I
H
P
V
A
G
R
M
P
G
Q
L
N
V
L
L
A
E
A
G
V
P
Y
D
I
V
L
E
M
D
E
I
N
H
D
F
P
D
T
D
L
V
L
V
I
G
A
N
D
T
V
N
S
A
A
Q
E
D
P
N
S
I
I
A
G
M
P
V
L
E
V
W
K
S
K
Q
V
I
V
M
K
R
S
L
G
V
G
Y
A
A
V
D
N
P
I
F
Y
K
P
N
T
A
M
L
L
G
D
A
K
K
T
C
D
A
L
Q
A
K
V
R
--
51
HHSearch
67.14
59%
-108
- C6 -
2BRU
2
C:
[20-186]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
E
E
T
A
E
L
L
K
N
S
H
S
V
I
I
T
P
G
Y
G
M
A
V
A
Q
A
Q
Y
P
V
A
E
I
T
E
K
L
R
A
R
G
I
N
V
R
F
G
I
H
P
V
A
G
R
L
P
G
H
M
N
V
L
L
A
E
A
K
V
P
Y
D
I
V
L
E
M
D
E
I
N
D
D
F
A
D
T
D
T
V
L
V
I
G
A
N
D
T
V
N
P
A
A
Q
D
D
P
K
S
P
I
A
G
M
P
V
L
E
V
W
K
A
Q
N
V
I
V
F
K
R
S
M
N
T
G
Y
A
G
V
Q
N
P
L
F
F
K
E
N
T
H
M
L
F
G
D
A
K
A
S
V
D
A
I
L
K
A
L
---
16
PsiBlast_PDB
66.85
61%
-108
- C6 -
2BRU
2
C:
[20-186]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
A
-----
E
E
T
A
E
L
L
K
N
S
H
S
V
I
I
T
P
G
Y
G
M
A
V
A
Q
A
Q
Y
P
V
A
E
I
T
E
K
L
R
A
R
G
I
N
V
R
F
G
I
H
P
V
A
G
R
L
P
G
H
M
N
V
L
L
A
E
A
K
V
P
Y
D
I
V
L
E
M
D
E
I
N
D
D
F
A
D
T
D
T
V
L
V
I
G
A
N
D
T
V
N
P
A
A
Q
D
D
P
K
S
P
I
A
G
M
P
V
L
E
V
W
K
A
Q
N
V
I
V
F
K
R
S
M
N
T
G
Y
A
G
V
Q
N
P
L
F
F
K
E
N
T
H
M
L
F
G
D
A
K
A
S
V
D
A
I
L
K
A
L
---
30
PsiBlast_CBE
66.84
56%
-110
- C6 -
1D4O
1
A:
[13-172]
------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
D
N
A
I
D
M
I
R
E
A
N
S
I
I
I
T
P
G
Y
G
L
C
A
A
K
A
Q
Y
P
I
A
D
L
V
K
M
L
S
E
Q
G
K
K
V
R
F
G
I
H
P
V
A
G
R
M
P
G
Q
L
N
V
L
L
A
E
A
G
V
P
Y
D
I
V
L
E
M
D
E
I
N
H
D
F
P
D
T
D
L
V
L
V
I
G
A
N
D
T
V
N
S
A
A
Q
E
D
P
N
S
I
I
A
G
M
P
V
L
E
V
W
K
S
K
Q
V
I
V
M
K
R
S
L
G
V
G
Y
A
A
V
D
N
P
I
F
Y
K
P
N
T
A
M
L
L
G
D
A
K
K
T
C
D
A
L
Q
A
K
V
R
--