@TOME V2.3
(Nov 2016)
Ref.
-
-
Doc.
Global output mode :
Sort entries by :
Atome Result
Tools Result
PDB occurence
Core Structure Cluster
Sequence Color type :
Secondary Structure
Hydrophobicity
Disulfide Bonds
TCoffee Identity Score
Uniprot annotation
Core Structure Cluster
Contacts with Ligands
Show alignment :
Atome selection
All alignments
Only Template with Ligand
Column output:
Score:
Atome Rank Value
Tools Score
Hide column
Alignment:
Sequence Identity (%)
Tcoffee Alignment Score
Hide column
3D Common Core:
Tito PKB Score
Verify3D Score
QMean Score
Hide column
Structural Clustering:
Cluster Num
3D-Jury Struct. Score
Hide column
Modeller Result :
Model Rank
QMean Score
Dfire Score
Dope Score
Errat Score
Verify3D Score
Modeller Score
Hide column
Complexes Modeling
Show Ligands of Templates
Complexes Affinity Score
Main Binding Site Identity
Hide column
Templates Information:
Uniprot entry
Cath class
Scop class
Smart class
Prosite class
Pfam class
EC Number
Taxonomy
Experiment Method
Hide column
Sequence & Result Tab:
PDB Template Sequence
Complexes Tab
Values color: [
Good
|
Correct
|
Middling
|
Bad
]
Sequence color :
Mutated
Helix
Strand
Conserved
Query sequence : PA0266: (2015-12-28 )
MSKTNESLLKRRQAAVPRGVGQIHPVVAERAENSTVWDVEGREYIDFAGGIAVLNTGHLHPKVIAAVQEQLGKLSHTCFQVLAYEPYIELAEEIAKRVPGDFPKKTLLVTSGSEAVENAVKIARAATGRAGVIAFTGAYHGRTMMTLGLTGKVVPYSAGMGLMPGGIFRALAPCELHGVSEDDSIASIERIFKNDAQPQDIAAIIIEPVQGEGGFYVNSKSFMQRLRALCDQHGILLIADEVQTGAGRTGTFFATEQLGIVPDLTTFAKSVGGGFPISGVAGKAEIMDAIAPGGLGGTYAGSPIACAAALAVLKVFEEEKLLERSQAVGERLKAGLREIQAKHKVIGDVRGLGSMVAIELFEGGDTHKPAAELVSKIVVRAREKGLILLSCGTYYNVIRFLMPVTIPDAQLEKGLAILAECFDELA
Atome Classification :
(39 SA)
.........10.........20........30........40........50.......-.60........70--.........80........90........100..--.....110.......120...------...-----.130----........140.......150........160---...--......170-----....------..--.---180-.......------.190...-....200.......210.......220.......230.......240.......250.......260.......270..-.....280.......290..---.....300.......310.......-320.......330.......340.......350.......360....-----...370.......380.-.......390.......400.......410.......420....
(Atome)
(Ident)
(Tito)
(Num)
(Ligand)
(Uniprot)
MSK
T
N
E
S
L
L
K
-
R
R
Q
A
AVPRGVGQI
H
P
V
V
A
ERAENS
T
V
W
DVEG
R
E
Y
I
DFAG
G
I
A
V
L
NTGH-L
H
P
K
V
I
A
A
V
Q
E
Q
---
L
G
K
L
S
H
T
C
F
Q
V
L
AYE
P
Y
I
E
L
A
E
E
I
A
K
RVPGDFP
K
--
K
T
L
L
VTSG
S
E
A
V
E
N
A
V
K
I
A
R
A------ATG-----R
A
G
-----
V
I
A
F
TGAYHG
R
T
M
M
T
LGLT-GKVVPYSAGM-----GLM--P
G
G
I
F
R
ALA-----PCEL------HG--V---SE--DD
S
I
A
S
I
------
E
R
I
F
KND-AQPQ
D
I
A
A
I
I
I
E
PVQGEG
G
F
Y
V
N
S
K
S
F
M
Q
R
L
R
A
L
C
D
QH
G
I
L
L
I
A
DEVQTGAGRT
G
T
F
F
A
T
E
QLGIVP
D
L
T
T
F
A
K
SVGGG-FPISGVA
G
K
A
E
I
M
D
A
IAPGG---LGGTYAG
S
P
I
A
C
A
A
A
L
A
V
L
K
V
F
E
E
E
-
K
L
L
E
R
S
Q
A
V
G
E
R
L
K
A
G
L
R
E
I
Q
A
K
H
K
V
I
G
D
V
R
GLG
S
M
V
A
I
E
L
FEGGDT-----HK
P
A
A
E
L
V
S
K
I
V
V
R
A-R-EK
G
L
I
L
L
SCG
T
Y
Y
N
V
I
R
F
L
MPVTI
P
D
A
Q
L
E
K
G
L
A
I
L
A
E
C
F
D
ELA
21
PsiBlast_CBE
99.70
73%
-105
- C1 -
1SFF
15
GABT_ECOLI
D:
[2-423]
--
N
S
N
K
E
L
M
Q
-
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
---
L
K
K
L
S
H
T
C
F
Q
V
L
A
Y
E
P
Y
L
E
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
--
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
------
A
T
K
-----
R
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
-
G
K
V
N
P
Y
S
A
G
M
-----
G
L
M
--
P
G
H
V
Y
R
A
L
Y
-----
P
C
P
L
------
H
G
--
I
---
S
E
--
D
D
A
I
A
S
I
------
H
R
I
F
K
N
D
-
A
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
P
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
G
R
A
E
V
M
D
A
V
A
P
G
G
---
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
-
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
F
E
D
G
D
H
-----
N
K
P
D
A
K
L
T
A
E
I
V
A
R
A
-
R
-
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
23
PsiBlast_CBE
98.43
73%
-104
- C1 -
1SFF
8
GABT_ECOLI
B:
[2-423]
--
N
S
N
K
E
L
M
Q
-
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
---
L
K
K
L
S
H
T
C
F
Q
V
L
A
Y
E
P
Y
L
E
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
--
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
------
A
T
K
-----
R
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
-
G
K
V
N
P
Y
S
A
G
M
-----
G
L
M
--
P
G
H
V
Y
R
A
L
Y
-----
P
C
P
L
------
H
G
--
I
---
S
E
--
D
D
A
I
A
S
I
------
H
R
I
F
K
N
D
-
A
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
P
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
G
R
A
E
V
M
D
A
V
A
P
G
G
---
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
-
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
F
E
D
G
D
H
-----
N
K
P
D
A
K
L
T
A
E
I
V
A
R
A
-
R
-
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
33
PsiBlast_CBE
98.32
73%
-103
- C1 -
1SZS
19
GABT_ECOLI
D:
[2-423]
--
N
S
N
K
E
L
M
Q
-
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
Q
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
---
L
K
K
L
S
H
T
C
F
Q
V
L
A
Y
E
P
Y
L
E
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
--
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
------
A
T
K
-----
R
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
-
G
K
V
N
P
Y
S
A
G
M
-----
G
L
M
--
P
G
H
V
Y
R
A
L
Y
-----
P
C
P
L
------
H
G
--
I
---
S
E
--
D
D
A
I
A
S
I
------
H
R
I
F
K
N
D
-
A
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
P
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
G
R
A
E
V
M
D
A
V
A
P
G
G
---
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
-
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
F
E
D
G
D
H
-----
N
K
P
D
A
K
L
T
A
E
I
V
A
R
A
-
R
-
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
27
PsiBlast_CBE
97.78
73%
-105
- C1 -
1SZU
18
GABT_ECOLI
D:
[2-423]
--
N
S
N
K
E
L
M
Q
-
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
---
L
K
K
L
S
H
T
C
F
Q
V
L
A
Y
E
P
Y
L
E
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
--
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
------
A
T
K
-----
R
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
-
G
K
V
N
P
Y
S
A
G
M
-----
G
L
M
--
P
G
H
V
Y
R
A
L
Y
-----
P
C
P
L
------
H
G
--
I
---
S
E
--
D
D
A
I
A
S
I
------
H
R
I
F
K
N
D
-
A
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
P
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
A
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
G
R
A
E
V
M
D
A
V
A
P
G
G
---
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
-
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
F
E
D
G
D
H
-----
N
K
P
D
A
K
L
T
A
E
I
V
A
R
A
-
R
-
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
35
PsiBlast_CBE
97.61
73%
-104
- C1 -
1SZS
9
GABT_ECOLI
B:
[2-423]
--
N
S
N
K
E
L
M
Q
-
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
Q
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
---
L
K
K
L
S
H
T
C
F
Q
V
L
A
Y
E
P
Y
L
E
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
--
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
------
A
T
K
-----
R
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
-
G
K
V
N
P
Y
S
A
G
M
-----
G
L
M
--
P
G
H
V
Y
R
A
L
Y
-----
P
C
P
L
------
H
G
--
I
---
S
E
--
D
D
A
I
A
S
I
------
H
R
I
F
K
N
D
-
A
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
P
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
G
R
A
E
V
M
D
A
V
A
P
G
G
---
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
-
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
F
E
D
G
D
H
-----
N
K
P
D
A
K
L
T
A
E
I
V
A
R
A
-
R
-
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
24
PsiBlast_CBE
97.54
73%
-103
- C1 -
1SF2
14
GABT_ECOLI
D:
[2-423]
--
N
S
N
K
E
L
M
Q
-
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
---
L
K
K
L
S
H
T
C
F
Q
V
L
A
Y
E
P
Y
L
E
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
--
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
------
A
T
K
-----
R
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
-
G
K
V
N
P
Y
S
A
G
M
-----
G
L
M
--
P
G
H
V
Y
R
A
L
Y
-----
P
C
P
L
------
H
G
--
I
---
S
E
--
D
D
A
I
A
S
I
------
H
R
I
F
K
N
D
-
A
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
P
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
G
R
A
E
V
M
D
A
V
A
P
G
G
---
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
-
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
F
E
D
G
D
H
-----
N
K
P
D
A
K
L
T
A
E
I
V
A
R
A
-
R
-
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
22
PsiBlast_CBE
97.05
73%
-104
- C1 -
1SFF
16
GABT_ECOLI
C:
[2-423]
--
N
S
N
K
E
L
M
Q
-
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
---
L
K
K
L
S
H
T
C
F
Q
V
L
A
Y
E
P
Y
L
E
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
--
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
------
A
T
K
-----
R
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
-
G
K
V
N
P
Y
S
A
G
M
-----
G
L
M
--
P
G
H
V
Y
R
A
L
Y
-----
P
C
P
L
------
H
G
--
I
---
S
E
--
D
D
A
I
A
S
I
------
H
R
I
F
K
N
D
-
A
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
P
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
G
R
A
E
V
M
D
A
V
A
P
G
G
---
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
-
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
F
E
D
G
D
H
-----
N
K
P
D
A
K
L
T
A
E
I
V
A
R
A
-
R
-
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
29
PsiBlast_CBE
96.86
73%
-103
- C1 -
1SZU
9
GABT_ECOLI
B:
[2-423]
--
N
S
N
K
E
L
M
Q
-
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
---
L
K
K
L
S
H
T
C
F
Q
V
L
A
Y
E
P
Y
L
E
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
--
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
------
A
T
K
-----
R
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
-
G
K
V
N
P
Y
S
A
G
M
-----
G
L
M
--
P
G
H
V
Y
R
A
L
Y
-----
P
C
P
L
------
H
G
--
I
---
S
E
--
D
D
A
I
A
S
I
------
H
R
I
F
K
N
D
-
A
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
P
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
A
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
G
R
A
E
V
M
D
A
V
A
P
G
G
---
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
-
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
F
E
D
G
D
H
-----
N
K
P
D
A
K
L
T
A
E
I
V
A
R
A
-
R
-
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
30
PsiBlast_CBE
96.75
73%
-102
- C1 -
1SZK
17
GABT_ECOLI
D:
[2-423]
--
N
S
N
K
E
L
M
Q
-
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
---
L
K
K
L
S
H
T
C
F
Q
V
L
A
Y
E
P
Y
L
E
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
--
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
------
A
T
K
-----
R
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
-
G
K
V
N
P
Y
S
A
G
M
-----
G
L
M
--
P
G
H
V
Y
R
A
L
Y
-----
P
C
P
L
------
H
G
--
I
---
S
E
--
D
D
A
I
A
S
I
------
H
R
I
F
K
N
D
-
A
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
S
G
G
F
Y
A
S
S
P
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
G
R
A
E
V
M
D
A
V
A
P
G
G
---
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
-
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
F
E
D
G
D
H
-----
N
K
P
D
A
K
L
T
A
E
I
V
A
R
A
-
R
-
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
4
PsiBlast_PDB
96.69
73%
-102
- C1 -
1SZK
6
GABT_ECOLI
A:
[2-423]
--
N
S
N
K
E
L
M
Q
-
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
---
L
K
K
L
S
H
T
C
F
Q
V
L
A
Y
E
P
Y
L
E
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
--
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
------
A
T
K
-----
R
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
-
G
K
V
N
P
Y
S
A
G
M
-----
G
L
M
--
P
G
H
V
Y
R
A
L
Y
-----
P
C
P
L
------
H
G
--
I
---
S
E
--
D
D
A
I
A
S
I
------
H
R
I
F
K
N
D
-
A
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
S
G
G
F
Y
A
S
S
P
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
G
R
A
E
V
M
D
A
V
A
P
G
G
---
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
-
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
F
E
D
G
D
H
-----
N
K
P
D
A
K
L
T
A
E
I
V
A
R
A
-
R
-
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
5
PsiBlast_PDB
96.65
73%
-103
- C1 -
1SZS
7
GABT_ECOLI
A:
[2-423]
--
N
S
N
K
E
L
M
Q
-
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
Q
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
---
L
K
K
L
S
H
T
C
F
Q
V
L
A
Y
E
P
Y
L
E
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
--
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
------
A
T
K
-----
R
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
-
G
K
V
N
P
Y
S
A
G
M
-----
G
L
M
--
P
G
H
V
Y
R
A
L
Y
-----
P
C
P
L
------
H
G
--
I
---
S
E
--
D
D
A
I
A
S
I
------
H
R
I
F
K
N
D
-
A
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
P
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
G
R
A
E
V
M
D
A
V
A
P
G
G
---
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
-
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
F
E
D
G
D
H
-----
N
K
P
D
A
K
L
T
A
E
I
V
A
R
A
-
R
-
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
28
PsiBlast_CBE
96.46
73%
-105
- C1 -
1SZU
16
GABT_ECOLI
C:
[2-423]
--
N
S
N
K
E
L
M
Q
-
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
---
L
K
K
L
S
H
T
C
F
Q
V
L
A
Y
E
P
Y
L
E
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
--
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
------
A
T
K
-----
R
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
-
G
K
V
N
P
Y
S
A
G
M
-----
G
L
M
--
P
G
H
V
Y
R
A
L
Y
-----
P
C
P
L
------
H
G
--
I
---
S
E
--
D
D
A
I
A
S
I
------
H
R
I
F
K
N
D
-
A
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
P
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
A
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
G
R
A
E
V
M
D
A
V
A
P
G
G
---
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
-
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
F
E
D
G
D
H
-----
N
K
P
D
A
K
L
T
A
E
I
V
A
R
A
-
R
-
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
26
PsiBlast_CBE
96.45
73%
-102
- C1 -
1SF2
12
GABT_ECOLI
B:
[2-423]
--
N
S
N
K
E
L
M
Q
-
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
---
L
K
K
L
S
H
T
C
F
Q
V
L
A
Y
E
P
Y
L
E
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
--
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
------
A
T
K
-----
R
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
-
G
K
V
N
P
Y
S
A
G
M
-----
G
L
M
--
P
G
H
V
Y
R
A
L
Y
-----
P
C
P
L
------
H
G
--
I
---
S
E
--
D
D
A
I
A
S
I
------
H
R
I
F
K
N
D
-
A
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
P
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
G
R
A
E
V
M
D
A
V
A
P
G
G
---
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
-
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
F
E
D
G
D
H
-----
N
K
P
D
A
K
L
T
A
E
I
V
A
R
A
-
R
-
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
3
PsiBlast_PDB
96.38
73%
-102
- C1 -
1SZU
7
GABT_ECOLI
A:
[2-423]
--
N
S
N
K
E
L
M
Q
-
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
---
L
K
K
L
S
H
T
C
F
Q
V
L
A
Y
E
P
Y
L
E
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
--
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
------
A
T
K
-----
R
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
-
G
K
V
N
P
Y
S
A
G
M
-----
G
L
M
--
P
G
H
V
Y
R
A
L
Y
-----
P
C
P
L
------
H
G
--
I
---
S
E
--
D
D
A
I
A
S
I
------
H
R
I
F
K
N
D
-
A
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
P
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
A
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
G
R
A
E
V
M
D
A
V
A
P
G
G
---
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
-
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
F
E
D
G
D
H
-----
N
K
P
D
A
K
L
T
A
E
I
V
A
R
A
-
R
-
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
2
PsiBlast_PDB
95.89
73%
-101
- C1 -
1SFF
9
GABT_ECOLI
A:
[2-423]
--
N
S
N
K
E
L
M
Q
-
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
---
L
K
K
L
S
H
T
C
F
Q
V
L
A
Y
E
P
Y
L
E
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
--
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
------
A
T
K
-----
R
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
-
G
K
V
N
P
Y
S
A
G
M
-----
G
L
M
--
P
G
H
V
Y
R
A
L
Y
-----
P
C
P
L
------
H
G
--
I
---
S
E
--
D
D
A
I
A
S
I
------
H
R
I
F
K
N
D
-
A
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
P
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
G
R
A
E
V
M
D
A
V
A
P
G
G
---
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
-
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
F
E
D
G
D
H
-----
N
K
P
D
A
K
L
T
A
E
I
V
A
R
A
-
R
-
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
25
PsiBlast_CBE
95.60
73%
-104
- C1 -
1SF2
9
GABT_ECOLI
C:
[2-423]
--
N
S
N
K
E
L
M
Q
-
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
---
L
K
K
L
S
H
T
C
F
Q
V
L
A
Y
E
P
Y
L
E
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
--
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
------
A
T
K
-----
R
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
-
G
K
V
N
P
Y
S
A
G
M
-----
G
L
M
--
P
G
H
V
Y
R
A
L
Y
-----
P
C
P
L
------
H
G
--
I
---
S
E
--
D
D
A
I
A
S
I
------
H
R
I
F
K
N
D
-
A
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
P
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
G
R
A
E
V
M
D
A
V
A
P
G
G
---
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
-
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
F
E
D
G
D
H
-----
N
K
P
D
A
K
L
T
A
E
I
V
A
R
A
-
R
-
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
114
HHSearch
95.39
74%
-104
- C1 -
1SFF
8
GABT_ECOLI
A:
[12-424]
-------------
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
---
L
K
K
L
S
H
T
C
F
Q
V
L
A
Y
E
P
Y
L
E
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
--
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
------
A
T
K
-----
R
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
-
G
K
V
N
P
Y
S
A
G
M
-----
G
L
M
--
P
G
H
V
Y
R
A
L
Y
-----
P
C
P
L
------
H
G
--
I
---
S
E
--
D
D
A
I
A
S
I
------
H
R
I
F
K
N
D
-
A
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
P
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
G
R
A
E
V
M
D
A
V
A
P
G
G
---
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
-
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
F
E
D
G
D
H
-----
N
K
P
D
A
K
L
T
A
E
I
V
A
R
A
-
R
-
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
31
PsiBlast_CBE
95.18
73%
-105
- C1 -
1SZK
15
GABT_ECOLI
C:
[2-423]
--
N
S
N
K
E
L
M
Q
-
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
---
L
K
K
L
S
H
T
C
F
Q
V
L
A
Y
E
P
Y
L
E
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
--
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
------
A
T
K
-----
R
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
-
G
K
V
N
P
Y
S
A
G
M
-----
G
L
M
--
P
G
H
V
Y
R
A
L
Y
-----
P
C
P
L
------
H
G
--
I
---
S
E
--
D
D
A
I
A
S
I
------
H
R
I
F
K
N
D
-
A
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
S
G
G
F
Y
A
S
S
P
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
G
R
A
E
V
M
D
A
V
A
P
G
G
---
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
-
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
F
E
D
G
D
H
-----
N
K
P
D
A
K
L
T
A
E
I
V
A
R
A
-
R
-
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
34
PsiBlast_CBE
95.07
73%
-103
- C1 -
1SZS
17
GABT_ECOLI
C:
[2-423]
--
N
S
N
K
E
L
M
Q
-
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
Q
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
---
L
K
K
L
S
H
T
C
F
Q
V
L
A
Y
E
P
Y
L
E
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
--
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
------
A
T
K
-----
R
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
-
G
K
V
N
P
Y
S
A
G
M
-----
G
L
M
--
P
G
H
V
Y
R
A
L
Y
-----
P
C
P
L
------
H
G
--
I
---
S
E
--
D
D
A
I
A
S
I
------
H
R
I
F
K
N
D
-
A
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
P
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
G
R
A
E
V
M
D
A
V
A
P
G
G
---
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
-
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
F
E
D
G
D
H
-----
N
K
P
D
A
K
L
T
A
E
I
V
A
R
A
-
R
-
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
1
PsiBlast_PDB
95.06
73%
-102
- C1 -
1SF2
7
GABT_ECOLI
A:
[2-423]
--
N
S
N
K
E
L
M
Q
-
R
R
S
Q
A
I
P
R
G
V
G
Q
I
H
P
I
F
A
D
R
A
E
N
C
R
V
W
D
V
E
G
R
E
Y
L
D
F
A
G
G
I
A
V
L
N
T
G
H
-
L
H
P
K
V
V
A
A
V
E
A
Q
---
L
K
K
L
S
H
T
C
F
Q
V
L
A
Y
E
P
Y
L
E
L
C
E
I
M
N
Q
K
V
P
G
D
F
A
K
--
K
T
L
L
V
T
T
G
S
E
A
V
E
N
A
V
K
I
A
R
A
------
A
T
K
-----
R
S
G
-----
T
I
A
F
S
G
A
Y
H
G
R
T
H
Y
T
L
A
L
T
-
G
K
V
N
P
Y
S
A
G
M
-----
G
L
M
--
P
G
H
V
Y
R
A
L
Y
-----
P
C
P
L
------
H
G
--
I
---
S
E
--
D
D
A
I
A
S
I
------
H
R
I
F
K
N
D
-
A
A
P
E
D
I
A
A
I
V
I
E
P
V
Q
G
E
G
G
F
Y
A
S
S
P
A
F
M
Q
R
L
R
A
L
C
D
E
H
G
I
M
L
I
A
D
E
V
Q
S
G
A
G
R
T
G
T
L
F
A
M
E
Q
M
G
V
A
P
D
L
T
T
F
A
K
S
I
A
G
G
-
F
P
L
A
G
V
T
G
R
A
E
V
M
D
A
V
A
P
G
G
---
L
G
G
T
Y
A
G
N
P
I
A
C
V
A
A
L
E
V
L
K
V
F
E
Q
E
-
N
L
L
Q
K
A
N
D
L
G
Q
K
L
K
D
G
L
L
A
I
A
E
K
H
P
E
I
G
D
V
R
G
L
G
A
M
I
A
I
E
L
F
E
D
G
D
H
-----
N
K
P
D
A
K
L
T
A
E
I
V
A
R
A
-
R
-
D
K
G
L
I
L
L
S
C
G
P
Y
Y
N
V
L
R
I
L
V
P
L
T
I
E
D
A
Q
I
R
Q
G
L
E
I
I
S
Q
C
F
D
E
A
K
116
HHSearch
66.41
36%
-104
- C1 -
1VEF
2
ARGD_THET8
A:
[26-395]
-----------------------
K
H
D
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
---
A
E
T
L
M
A
M
P
Q
-
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
P
-
E
L
N
--
R
V
F
P
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
------
H
T
G
-----
R
K
K
-----
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
-
W
E
P
K
-
Y
R
E
P
F
-----
L
P
L
--
V
E
P
V
E
F
I
P
Y
-----
N
D
V
E
------
A
-----------------
L
------
K
R
A
V
D
------
E
E
T
A
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
P
K
G
G
---
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
-
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
R
A
I
P
S
--
P
K
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
K
E
K
---------------
A
A
P
Y
I
A
R
L
-
E
K
E
H
R
V
L
A
L
Q
A
--
G
P
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
A
---
129
HHSearch
63.61
33%
-101
* C1 *
2ORD
14
ARGD_THEMA
A:
[21-396]
-----------------------
R
F
P
A
T
F
V
Y
G
K
G
S
W
I
Y
D
E
K
G
N
A
Y
L
D
F
T
S
G
I
A
V
N
V
L
G
H
-
S
H
P
R
L
V
E
A
I
K
D
Q
---
A
E
K
L
I
H
C
S
N
-
L
F
W
N
R
P
Q
M
E
L
A
E
L
L
S
K
N
T
F
---
G
G
--
K
V
F
F
A
N
T
G
T
E
A
N
E
A
A
I
K
I
A
R
K
------
Y
G
K
K
K
SEK
K
Y
R
-----
I
L
S
A
H
N
S
F
H
G
R
T
L
G
S
L
T
A
T
-
G
Q
P
K
-
Y
Q
K
P
F
-----
E
P
L
--
V
P
G
F
E
Y
F
E
F
-----
N
N
V
E
------
D
-----------------
L
------
R
R
K
M
S
------
E
D
V
C
A
V
F
L
E
P
I
Q
G
E
S
G
I
V
P
A
T
K
E
F
L
E
E
A
R
K
L
C
D
E
Y
D
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
K
L
F
A
Y
Q
K
Y
G
V
V
P
D
V
L
T
T
A
K
G
L
G
G
G
-
V
P
I
G
A
V
I
V
N
E
R
A
-
N
V
L
E
P
G
D
---
H
G
T
T
F
G
G
N
P
L
A
C
R
A
G
V
T
V
I
K
E
L
T
K
E
-
G
F
L
E
E
V
E
E
K
G
N
Y
L
M
K
K
L
Q
E
M
K
E
E
Y
D
V
V
A
D
V
R
G
M
G
L
M
I
G
I
Q
F
R
E
E
-------------
V
S
N
R
E
V
A
T
K
C
-
F
-
E
N
K
L
L
V
V
P
--
A
G
N
N
T
I
R
F
L
P
P
L
T
V
E
Y
G
E
I
D
L
A
V
E
T
L
K
K
V
L
Q
G
I
-
71
PsiBlast_CBE
58.77
33%
-102
- C1 -
2EO5
3
?
A:
[22-414]
----------------------
E
L
F
P
L
V
I
D
H
G
E
G
V
W
I
Y
D
V
D
G
N
K
Y
L
D
F
T
S
G
I
G
V
N
N
L
G
W
P
S
H
P
E
V
I
K
I
G
I
E
Q
---
M
Q
K
L
A
H
A
A
A
N
D
F
Y
N
I
P
Q
L
E
L
A
K
K
L
V
T
Y
S
P
G
N
F
Q
K
--
K
V
F
F
S
N
S
G
T
E
A
I
E
A
S
I
K
V
V
K
N
-------
T
G
-----
R
K
Y
-----
I
I
A
F
L
G
G
F
H
G
R
T
F
G
S
I
S
L
T
A
S
K
A
V
Q
R
S
I
V
G
-----
P
F
M
--
P
G
V
I
H
V
P
Y
P
NPYRN
P
W
H
I
------
N
G
--
Y
---
E
N
--
P
S
E
L
V
N
R
V
I
E
F
I
E
D
Y
I
F
V
N
L
-
V
P
P
E
E
V
A
G
I
F
F
E
P
I
Q
G
E
G
G
Y
V
I
P
P
K
N
F
F
A
E
L
Q
K
L
A
K
K
Y
G
I
L
L
V
D
D
E
V
Q
M
G
L
G
R
T
G
K
L
F
A
I
E
N
F
N
T
V
P
D
V
I
T
L
A
K
A
L
G
G
G
I
M
P
I
G
A
T
I
F
R
K
D
L
--
D
F
K
---------
T
F
G
G
N
A
L
A
C
A
I
G
S
K
V
I
D
I
V
K
D
---
L
L
P
H
V
N
E
I
G
---
K
I
F
A
E
E
L
Q
G
---
L
A
D
D
V
R
G
I
G
L
A
W
G
L
E
Y
N
E
-------------
K
K
V
R
D
R
I
I
G
E
S
-
F
-
K
R
G
L
L
L
L
P
A
G
R
--
S
A
I
R
V
I
P
P
L
V
I
S
E
E
E
A
K
Q
G
L
D
I
L
K
K
V
I
K
V
V
-
72
PsiBlast_CBE
57.69
34%
-94
- C1 -
2EH6
2
ARGD_AQUAE
B:
[11-373]
-------------------------
P
V
K
F
V
R
G
K
G
V
Y
L
Y
D
E
E
G
K
E
Y
L
D
F
V
S
G
I
G
V
N
S
L
G
H
-
A
Y
P
K
L
T
E
A
L
K
E
Q
---
V
E
K
L
L
H
V
S
--
N
L
Y
E
N
P
W
---
Q
E
E
L
A
H
K
L
V
K
H
F
W
T
EG
K
V
F
F
A
N
S
G
T
E
S
V
E
A
A
I
K
L
A
R
K
YWRDK-
G
K
N
-----
K
W
K
-----
F
I
S
F
E
N
S
F
H
G
R
T
Y
G
S
L
S
A
T
-
G
Q
P
K
F
H
K
G
F
E
-----
P
L
V
--
P
G
F
S
Y
A
K
L
-----------------------------
N
D
I
D
S
V
------
Y
K
L
L
D
------
E
E
T
A
G
I
I
I
E
V
I
Q
G
E
G
G
V
N
E
A
S
E
D
F
L
S
K
L
Q
E
I
C
K
E
K
D
V
L
L
I
I
D
E
V
Q
T
G
I
G
R
T
G
E
F
Y
A
Y
Q
H
F
N
L
K
P
D
V
I
A
L
A
K
G
L
G
G
G
-
V
P
I
G
A
I
L
A
R
E
E
V
A
Q
S
F
T
P
G
S
---
H
G
S
T
F
G
G
N
P
L
A
C
R
A
G
T
V
V
--
V
D
E
V
E
-
K
L
L
P
H
V
R
E
V
G
N
Y
F
K
E
K
L
K
E
L
G
K
-----
G
K
V
K
G
R
G
L
M
L
G
L
E
L
---------------
E
R
E
C
K
D
Y
V
L
K
A
-
L
-
E
K
G
L
-
L
I
N
C
-
T
A
G
K
V
L
R
F
L
P
P
L
I
I
Q
K
E
H
I
D
R
A
I
S
V
L
R
E
I
L
----
58
PsiBlast_CBE
57.65
34%
-94
- C1 -
4JEY
13
ARGD_SALTY
B:
[45-413]
------------------------------
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
---
G
E
T
L
W
H
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
---
K
L
I
D
A
T
F
A
E
--
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
S
P
F
-----
K
T
K
-----
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
-
G
Q
P
-
K
Y
S
D
G
F
-----
G
P
K
--
P
A
D
I
I
H
-
V
P
-----
F
N
D
L
------
H
A
--
V
---
K
A
V
M
D
D
H
T
C
-----------------------
A
V
V
V
E
P
I
Q
G
A
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
H
V
G
S
---
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
-
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
------------
K
P
K
Y
K
G
R
A
R
D
F
L
Y
A
G
A
-
E
A
G
V
M
V
L
N
A
G
A
--
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
V
55
PsiBlast_CBE
57.34
34%
-93
- C1 -
2PB0
5
ARGD_SALTY
B:
[45-413]
------------------------------
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
---
G
E
T
L
W
H
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
---
K
L
I
D
A
T
F
A
E
--
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
S
P
F
-----
K
T
K
-----
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
-
G
Q
P
-
K
Y
S
D
G
F
-----
G
P
K
--
P
A
D
I
I
H
-
V
P
-----
F
N
D
L
------
H
A
--
V
---
K
A
V
M
D
D
H
T
C
-----------------------
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
H
V
G
S
---
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
A
F
D
I
I
N
T
P
-
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
------------
K
P
K
Y
K
G
R
A
R
D
F
L
Y
A
G
A
-
E
A
G
V
M
V
L
N
A
G
A
--
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
V
53
PsiBlast_CBE
57.33
34%
-93
- C1 -
4JEW
13
ARGD_SALTY
B:
[45-413]
------------------------------
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
---
G
E
T
L
W
H
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
---
K
L
I
D
A
T
F
A
E
--
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
S
P
F
-----
K
T
K
-----
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
-
G
Q
P
-
K
Y
S
D
G
F
-----
G
P
K
--
P
A
D
I
I
H
-
V
P
-----
F
N
D
L
------
H
A
--
V
---
K
A
V
M
D
D
H
T
C
-----------------------
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
H
V
G
S
---
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
-
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
------------
K
P
K
Y
K
G
R
A
R
D
F
L
Y
A
G
A
-
E
A
G
V
M
V
L
N
A
G
A
--
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
V
57
PsiBlast_CBE
56.75
34%
-94
- C1 -
4JF1
9
ARGD_SALTY
B:
[45-413]
------------------------------
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
---
G
E
T
L
W
H
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
---
K
L
I
D
A
T
F
A
E
--
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
S
P
F
-----
K
T
K
-----
I
I
A
F
H
N
A
F
H
G
Q
S
L
F
T
V
S
V
G
-
G
Q
P
-
K
Y
S
D
G
F
-----
G
P
K
--
P
A
D
I
I
H
-
V
P
-----
F
N
D
L
------
H
A
--
V
---
K
A
V
M
D
D
H
T
C
-----------------------
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
H
V
G
S
---
H
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
-
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
------------
K
P
K
Y
K
G
R
A
R
D
F
L
Y
A
G
A
-
E
A
G
V
M
V
L
N
A
G
A
--
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
V
56
PsiBlast_CBE
56.66
34%
-95
- C1 -
4JEX
17
ARGD_SALTY
B:
[45-413]
------------------------------
K
G
K
G
S
R
V
W
D
Q
Q
G
K
E
Y
I
D
F
A
G
G
I
A
V
T
A
L
G
H
-
C
H
P
A
L
V
E
A
L
K
S
Q
---
G
E
T
L
W
H
T
S
-
N
V
F
T
N
E
P
A
L
R
L
G
R
---
K
L
I
D
A
T
F
A
E
--
R
V
L
F
M
N
S
G
T
E
A
N
E
T
A
F
K
L
A
R
H
Y
A
C
V
R
H
S
P
F
-----
K
T
K
-----
I
I
A
F
H
N
A
F
H
G
R
S
L
F
T
V
S
V
G
-
G
Q
P
-
K
Y
S
D
G
F
-----
G
P
K
--
P
A
D
I
I
H
-
V
P
-----
F
N
D
L
------
H
A
--
V
---
K
A
V
M
D
D
H
T
C
-----------------------
A
V
V
V
E
P
I
Q
G
E
G
G
V
Q
A
A
T
P
E
F
L
K
G
L
R
D
L
C
D
E
H
Q
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
D
L
F
A
Y
M
H
Y
G
V
T
P
D
I
L
T
S
A
K
A
L
G
G
G
-
F
P
V
S
A
M
L
T
T
Q
E
I
A
S
A
F
--------
G
S
T
Y
G
G
N
P
L
A
C
A
V
A
G
A
T
F
D
I
I
N
T
P
-
E
V
L
Q
G
I
H
T
K
R
Q
Q
F
V
Q
H
L
Q
A
I
D
E
Q
F
D
I
F
S
D
I
R
G
M
G
L
L
I
G
A
E
L
------------
K
P
K
Y
K
G
R
A
R
D
F
L
Y
A
G
A
-
E
A
G
V
M
V
L
N
A
G
A
--
D
V
M
R
F
A
P
S
L
V
V
E
E
A
D
I
H
E
G
M
Q
R
F
A
Q
A
V
G
K
V
V
70
PsiBlast_CBE
56.09
32%
-94
- C1 -
2E54
5
ARGD_THEMA
A:
[20-378]
----------------------------------
S
W
I
Y
D
E
K
G
N
A
Y
L
D
F
T
S
G
I
A
V
N
V
L
G
H
-
S
H
P
R
L
V
E
A
I
K
D
Q
---
A
E
K
L
I
H
-
C
S
N
L
F
W
N
R
P
Q
M
E
L
A
E
L
L
S
K
N
T
---
F
G
G
--
K
V
F
F
A
N
T
G
T
E
A
N
E
A
A
I
K
I
A
R
K
------
Y
G
K
-----
K
K
S
EKKY
R
I
L
S
A
H
N
S
F
H
G
R
T
L
G
S
L
T
A
T
-
G
Q
P
K
Y
Q
K
P
F
E
-----
P
L
V
--
P
G
F
E
Y
---------------------------
F
E
--
F
N
N
V
E
D
L
------
R
R
------
K
M
S
E
D
V
C
A
V
F
L
E
P
I
Q
G
E
S
G
I
V
P
A
T
K
E
F
L
E
E
A
R
K
L
C
D
E
Y
D
A
L
L
V
F
D
E
V
Q
C
G
M
G
R
T
G
K
L
F
A
Y
Q
K
Y
G
V
V
P
D
V
L
T
T
A
K
G
L
G
G
G
-
V
P
I
G
A
V
I
V
N
-
E
R
A
N
V
L
E
P
G
D
---
H
G
T
T
F
G
G
N
P
L
A
C
R
A
G
V
T
V
I
K
E
L
T
K
E
-
G
F
L
E
E
V
E
E
K
G
N
Y
L
M
K
K
L
Q
E
M
K
E
E
Y
D
V
V
A
D
V
R
G
M
G
L
M
I
G
I
Q
F
R
E
E
V
S
N
-----
R
--------
E
V
A
T
K
C
-
F
-
E
N
K
L
L
V
V
P
A
G
N
--
N
T
I
R
F
L
P
P
L
T
V
E
Y
G
E
I
D
L
A
V
E
T
L
K
K
V
L
Q
G
I
-
127
HHSearch
56.02
33%
-93
- C1 -
2EO5
3
?
A:
[2-418]
-
L
S
R
K
I
I
E
E
S
D
I
Y
L
A
T
S
T
R
D
-
P
E
L
F
P
L
V
I
D
H
G
E
G
V
W
I
Y
D
V
D
G
N
K
Y
L
D
F
T
S
G
I
G
V
N
N
L
G
W
P
S
H
P
E
V
I
K
I
G
I
E
Q
---
M
Q
K
L
A
H
A
A
A
N
D
F
Y
N
I
P
Q
L
E
L
A
K
K
L
V
T
Y
S
P
G
N
F
Q
K
--
K
V
F
F
S
N
S
G
T
E
A
I
E
A
S
I
K
V
V
K
N
------
T
-
G
-----
R
K
Y
-----
I
I
A
F
L
G
G
F
H
G
R
T
F
G
S
I
S
L
T
-
A
S
K
A
V
Q
R
S
I
V
-----
G
P
F
--
M
P
G
V
I
H
V
P
Y
-----
P
N
P
Y
RNPWHI
N
G
YE
N
P
S
E
L
V
--
N
R
V
I
E
F
I
------
E
D
Y
I
F
V
N
L
V
P
P
E
E
V
A
G
I
F
F
E
P
I
Q
G
E
G
G
Y
V
I
P
P
K
N
F
F
A
E
L
Q
K
L
A
K
K
Y
G
I
L
L
V
D
D
E
V
Q
M
G
L
G
R
T
G
K
L
F
A
I
E
N
F
N
T
V
P
D
V
I
T
L
A
K
A
L
G
G
G
I
M
P
I
G
A
T
I
F
R
K
D
L
D
--
F
K
---------
T
F
G
G
N
A
L
A
C
A
I
G
S
K
V
I
D
I
V
K
---
D
L
L
P
H
V
N
E
I
G
K
I
F
A
E
E
L
Q
G
L
A
------
D
D
V
R
G
I
G
L
A
W
G
L
E
Y
N
E
K
-------------
K
V
R
D
R
I
I
G
E
S
-
F
-
K
R
G
L
L
L
L
P
A
--
G
R
S
A
I
R
V
I
P
P
L
V
I
S
E
E
E
A
K
Q
G
L
D
I
L
K
K
V
I
K
V
V
-
73
PsiBlast_CBE
55.92
34%
-94
- C1 -
2EH6
2
ARGD_AQUAE
A:
[11-373]
-------------------------
P
V
K
F
V
R
G
K
G
V
Y
L
Y
D
E
E
G
K
E
Y
L
D
F
V
S
G
I
G
V
N
S
L
G
H
-
A
Y
P
K
L
T
E
A
L
K
E
Q
---
V
E
K
L
L
H
V
S
--
N
L
Y
E
N
P
W
---
Q
E
E
L
A
H
K
L
V
K
H
F
W
T
E
G
K
V
F
F
A
N
S
G
T
E
S
V
E
A
A
I
K
L
A
R
K
Y
W
R
D
K
-
G
K
N
-----
K
W
K
-----
F
I
S
F
E
N
S
F
H
G
R
T
Y
G
S
L
S
A
T
-
G
Q
P
K
F
H
K
G
F
E
-----
P
L
V
--
P
G
F
S
Y
A
K
L
-----------------------------
N
D
I
D
S
V
------
Y
K
L
L
D
------
E
E
T
A
G
I
I
I
E
V
I
Q
G
E
G
G
V
N
E
A
S
E
D
F
L
S
K
L
Q
E
I
C
K
E
K
D
V
L
L
I
I
D
E
V
Q
T
G
I
G
R
T
G
E
F
Y
A
Y
Q
H
F
N
L
K
P
D
V
I
A
L
A
K
G
L
G
G
G
-
V
P
I
G
A
I
L
A
R
E
E
V
A
Q
S
F
T
P
G
S
---
H
G
S
T
F
G
G
N
P
L
A
C
R
A
G
T
V
V
--
V
D
E
V
E
-
K
L
L
P
H
V
R
E
V
G
N
Y
F
K
E
K
L
K
E
L
G
K
-----
G
K
V
K
G
R
G
L
M
L
G
L
E
L
---------------
E
R
E
C
K
D
Y
V
L
K
A
-
L
-
E
K
G
L
-
L
I
N
C
-
T
A
G
K
V
L
R
F
L
P
P
L
I
I
Q
K
E
H
I
D
R
A
I
S
V
L
R
E
I
L
----
83
PsiBlast_CBE
51.17
35%
-89
- C1 -
1VEF
2
ARGD_THET8
A:
[22-385]
-------------------
G
V
Y
N
K
H
D
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
M
A
M
P
Q
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
P
E
L
N
R
V
F
P
-------
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
------
H
T
G
-----
R
K
K
-----
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
-
W
E
P
K
Y
R
E
P
F
L
-----
P
L
----------
V
E
-----
P
V
E
F
------
I
P
--
Y
---
N
D
--
V
E
A
L
--------------
K
R
-
A
V
D
E
E
T
A
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
P
K
G
G
---
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
-
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
R
A
I
P
S
P
K
--
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
K
E
K
-----------
A
A
P
Y
I
A
R
L
---
E
-
K
-
E
H
R
V
L
A
L
Q
A
G
P
--
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
A
---
80
PsiBlast_CBE
50.73
35%
-86
- C1 -
1WKG
2
ARGD_THET8
B:
[22-385]
-------------------
G
V
Y
N
K
H
D
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
AET
L
M
A
M
P
Q
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
P
E
L
N
R
V
F
P
-------
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
------
H
T
G
-----
R
K
K
-----
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
-
W
E
P
K
Y
R
E
P
F
L
-----
P
L
----------
V
E
-----
P
V
E
F
------
I
P
--
Y
---
N
D
--
V
E
A
L
--------------
K
R
-
A
V
D
E
E
T
A
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
P
K
G
G
---
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
-
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
R
A
I
P
S
P
K
--
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
K
E
K
-----------
A
A
P
Y
I
A
R
L
---
E
-
K
-
E
H
R
V
L
A
L
Q
A
G
P
--
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
A
---
79
PsiBlast_CBE
50.63
35%
-86
- C1 -
1WKH
2
ARGD_THET8
A:
[22-385]
-------------------
G
V
Y
N
K
H
D
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
M
A
M
P
Q
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
P
E
L
N
R
V
F
P
-------
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
------
H
T
G
-----
R
K
K
-----
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
-
W
E
P
K
Y
R
E
P
F
L
-----
P
L
----------
V
E
-----
P
V
E
F
------
I
P
--
Y
---
N
D
--
V
E
A
L
--------------
K
R
-
A
V
D
E
E
T
A
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
P
K
G
G
---
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
-
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
R
A
I
P
S
P
K
--
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
K
E
K
-----------
A
A
P
Y
I
A
R
L
---
E
-
K
-
E
H
R
V
L
A
L
Q
A
G
P
--
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
A
---
82
PsiBlast_CBE
50.35
35%
-87
- C1 -
1VEF
2
ARGD_THET8
B:
[22-385]
-------------------
G
V
Y
N
K
H
D
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
AET
L
M
A
M
P
Q
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
P
E
L
N
R
V
F
P
-------
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
------
H
T
G
-----
R
K
K
-----
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
-
W
E
P
K
Y
R
E
P
F
L
-----
P
L
----------
V
E
-----
P
V
E
F
------
I
P
--
Y
---
N
D
--
V
E
A
L
--------------
K
R
-
A
V
D
E
E
T
A
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
P
K
G
G
---
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
-
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
R
A
I
P
S
P
K
--
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
K
E
K
-----------
A
A
P
Y
I
A
R
L
---
E
-
K
-
E
H
R
V
L
A
L
Q
A
G
P
--
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
A
---
81
PsiBlast_CBE
49.70
35%
-90
- C1 -
1WKG
2
ARGD_THET8
A:
[22-385]
-------------------
G
V
Y
N
K
H
D
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
A
E
T
L
M
A
M
P
Q
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
P
E
L
N
R
V
F
P
-------
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
------
H
T
G
-----
R
K
K
-----
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
-
W
E
P
K
Y
R
E
P
F
L
-----
P
L
----------
V
E
-----
P
V
E
F
------
I
P
--
Y
---
N
D
--
V
E
A
L
--------------
K
R
-
A
V
D
E
E
T
A
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
P
K
G
G
---
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
-
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
R
A
I
P
S
P
K
--
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
K
E
K
-----------
A
A
P
Y
I
A
R
L
---
E
-
K
-
E
H
R
V
L
A
L
Q
A
G
P
--
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
A
---
78
PsiBlast_CBE
49.68
35%
-87
- C1 -
1WKH
2
ARGD_THET8
B:
[22-385]
-------------------
G
V
Y
N
K
H
D
L
L
I
V
R
G
Q
G
A
R
V
W
D
A
E
G
N
E
Y
I
D
C
V
G
G
Y
G
V
A
N
L
G
H
-
G
N
P
E
V
V
E
A
V
K
R
Q
AET
L
M
A
M
P
Q
T
L
P
T
P
M
R
G
E
F
Y
R
T
L
T
A
I
L
P
P
E
L
N
R
V
F
P
-------
V
N
S
G
T
E
A
N
E
A
A
L
K
F
A
R
A
------
H
T
G
-----
R
K
K
-----
F
V
A
A
M
R
G
F
S
G
R
T
M
G
S
L
S
V
T
-
W
E
P
K
Y
R
E
P
F
L
-----
P
L
----------
V
E
-----
P
V
E
F
------
I
P
--
Y
---
N
D
--
V
E
A
L
--------------
K
R
-
A
V
D
E
E
T
A
A
V
I
L
E
P
V
Q
G
E
G
G
V
R
P
A
T
P
E
F
L
R
A
A
R
E
I
T
Q
E
K
G
A
L
L
I
L
D
E
I
Q
T
G
M
G
R
T
G
K
R
F
A
F
E
H
F
G
I
V
P
D
I
L
T
L
A
K
A
L
G
G
G
-
V
P
L
G
V
A
V
M
R
E
E
V
A
R
S
M
P
K
G
G
---
H
G
T
T
F
G
G
N
P
L
A
M
A
A
G
V
A
A
I
R
Y
L
E
R
T
-
R
L
W
E
R
A
A
E
L
G
P
W
F
M
E
K
L
R
A
I
P
S
P
K
--
I
R
E
V
R
G
M
G
L
M
V
G
L
E
L
K
E
K
-----------
A
A
P
Y
I
A
R
L
---
E
-
K
-
E
H
R
V
L
A
L
Q
A
G
P
--
T
V
I
R
F
L
P
P
L
V
I
E
K
E
D
L
E
R
V
V
E
A
V
R
A
V
L
A
---
131
HHSearch
49.01
32%
-91
- C1 -
2E7U
4
GSA_THET8
A:
[33-424]
-----------------------
G
T
P
P
F
L
V
R
G
E
G
A
Y
V
W
D
A
D
G
N
R
Y
L
D
Y
V
M
S
W
G
P
L
I
L
G
H
-
A
H
P
K
V
L
A
R
V
R
E
T
---
L
E
R
G
L
T
F
G
---
A
P
S
P
L
E
V
A
L
A
K
K
V
K
R
A
Y
P
F
--
V
D
--
L
V
R
F
V
N
S
G
T
E
A
T
M
S
A
L
R
L
A
R
G
------
Y
T
G
-----
R
P
Y
-----
I
V
K
F
R
G
N
Y
H
G
H
A
D
G
L
L
V
E
A
-
G
S
G
A
-
L
T
L
G
V
PSSAG
V
P
E
EY
A
K
L
T
L
V
L
E
Y
-----
N
D
P
E
------
G
-----------------
L
------
R
E
V
L
K
R
R
---
G
E
E
I
A
A
I
I
F
E
P
V
V
G
N
A
G
V
L
V
-
P
T
E
D
F
L
K
A
L
H
E
A
K
A
Y
G
V
L
L
I
A
D
E
V
M
T
G
F
-
R
L
A
F
G
G
A
T
E
L
L
G
L
K
P
D
L
V
T
L
G
K
I
L
G
G
G
-
L
P
A
A
A
Y
A
G
R
R
E
I
M
E
K
V
A
P
L
G
P
V
Y
Q
A
G
T
L
S
G
N
P
L
A
M
A
A
G
L
A
T
L
E
L
L
E
E
N
P
G
Y
Y
A
Y
L
E
D
L
G
A
R
L
E
A
G
L
K
E
V
L
K
E
K
G
L
P
H
T
V
N
R
V
G
S
M
I
T
V
F
F
T
E
G
P
V
V
T
F
Q
D
A
R
R
T
D
T
E
L
F
K
R
F
F
H
G
L
-
L
-
D
R
G
I
Y
W
P
P
S
----
N
F
E
A
A
F
L
S
V
A
H
R
E
E
D
V
E
K
T
L
E
A
L
R
K
A
L
----